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Gene: Fen1 (flap structure specific endonuclease 1) Mus musculus
Symbol: Fen1
Name: flap structure specific endonuclease 1
Description: Exhibits DNA binding activity; metal ion binding activity; and nuclease activity. Involved in DNA repair and DNA replication. Predicted to colocalize with the nuclear chromosome, telomeric region. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human FEN1 (flap structure-specific endonuclease 1); PARTICIPATES IN base excision repair pathway; DNA replication pathway; non-homologous end joining pathway of double-strand break repair; INTERACTS WITH (+)-dexrazoxane; 1,1-dichloroethene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW538437; FEN-1; flap endonuclease 1; flap structure-specific endonuclease 1
Homo sapiens (human) : FEN1 (flap structure-specific endonuclease 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fen1 (flap structure-specific endonuclease 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fen1 (flap structure-specific endonuclease 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FEN1 (flap structure-specific endonuclease 1)
Canis lupus familiaris (dog) : FEN1 (flap structure-specific endonuclease 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fen1 (flap structure-specific endonuclease 1)
Sus scrofa (pig) : FEN1 (flap structure-specific endonuclease 1)
Chlorocebus sabaeus (green monkey) : FEN1 (flap structure-specific endonuclease 1)
Heterocephalus glaber (naked mole-rat) : Fen1 (flap structure-specific endonuclease 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1910,199,132 - 10,204,169 (-)Ensembl
GRCm381910,199,132 - 10,204,393 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371910,273,629 - 10,278,433 (-)NCBIGRCm37mm9NCBIm37
MGSCv361910,266,184 - 10,270,988 (-)NCBImm8
Celera1910,895,049 - 10,899,860 (-)NCBICelera
Cytogenetic Map19 ANCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Fen1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732680
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.