Hpn (hepsin) - Rat Genome Database

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Gene: Hpn (hepsin) Mus musculus
Analyze
Symbol: Hpn
Name: hepsin
RGD ID: 62274
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase activity. Involved in several processes, including cochlea morphogenesis; detection of mechanical stimulus involved in sensory perception of sound; and pilomotor reflex. Acts upstream of or within cholesterol homeostasis and sensory perception of sound. Located in cell-cell junction; neuronal cell body; and plasma membrane. Is expressed in several structures, including early conceptus; genitourinary system; gut; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human HPN (hepsin).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AA408042; AI788568; Hlb32; Hlb320; serine protease hepsin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,798,150 - 30,814,751 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,798,150 - 30,814,715 (-)EnsemblGRCm39 Ensembl
GRCm38731,098,725 - 31,115,326 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl731,098,725 - 31,115,290 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,883,744 - 31,900,309 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36730,807,485 - 30,824,034 (-)NCBIMGSCv36mm8
Celera725,667,468 - 25,684,520 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map719.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
C60 fullerene  (ISO)
calcitriol  (ISO)
chlordecone  (EXP)
chlorpromazine  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
clomipramine  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
disodium selenite  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
erythromycin A  (ISO)
flecainide  (ISO)
fluoxetine  (ISO)
imipramine  (ISO)
ketoconazole  (ISO)
loratadine  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
N-Nitrosopyrrolidine  (ISO)
nitroglycerin  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentamidine  (ISO)
perfluorobutyric acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perhexiline  (ISO)
pirinixic acid  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
selenium atom  (ISO)
selenomethionine  (ISO)
sertraline  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (ISO)
thioridazine  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
zimeldine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing. Liu Y, etal., Hum Mol Genet. 2022 Nov 10;31(22):3769-3776. doi: 10.1093/hmg/ddac129.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8346233   PMID:9395459   PMID:9435303   PMID:10349636   PMID:10411637   PMID:11042159   PMID:11076861   PMID:11127869   PMID:12477932   PMID:12696750   PMID:12744720   PMID:12962630  
PMID:14691545   PMID:15324701   PMID:16141072   PMID:16141073   PMID:16428450   PMID:16908524   PMID:17174946   PMID:17620368   PMID:17918732   PMID:18287559   PMID:18554416   PMID:18726901  
PMID:18784072   PMID:18973680   PMID:19911255   PMID:19938013   PMID:20152175   PMID:20683358   PMID:21267068   PMID:21386911   PMID:21677750   PMID:21873635   PMID:21947380   PMID:22505209  
PMID:22912808   PMID:26673890   PMID:31444371   PMID:32325033   PMID:32404422   PMID:35639639  


Genomics

Comparative Map Data
Hpn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,798,150 - 30,814,751 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,798,150 - 30,814,715 (-)EnsemblGRCm39 Ensembl
GRCm38731,098,725 - 31,115,326 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl731,098,725 - 31,115,290 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,883,744 - 31,900,309 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36730,807,485 - 30,824,034 (-)NCBIMGSCv36mm8
Celera725,667,468 - 25,684,520 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map719.3NCBI
HPN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,040,506 - 35,066,573 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,040,506 - 35,066,573 (+)EnsemblGRCh38hg38GRCh38
GRCh371935,531,410 - 35,557,477 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,223,250 - 40,249,315 (+)NCBINCBI36Build 36hg18NCBI36
Build 341940,223,249 - 40,249,315NCBI
Celera1932,245,008 - 32,271,054 (+)NCBICelera
Cytogenetic Map19q13.11NCBI
HuRef1932,039,443 - 32,065,498 (+)NCBIHuRef
CHM1_11935,533,351 - 35,559,397 (+)NCBICHM1_1
T2T-CHM13v2.01937,585,124 - 37,611,169 (+)NCBIT2T-CHM13v2.0
Hpn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8195,464,468 - 95,480,169 (-)NCBIGRCr8
mRatBN7.2186,337,085 - 86,352,785 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,337,087 - 86,352,811 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,757,532 - 91,773,231 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01100,223,689 - 100,239,390 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0193,515,821 - 93,531,524 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0189,534,112 - 89,549,575 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,534,106 - 89,543,967 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,688,659 - 90,704,122 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,145,615 - 86,161,091 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,223,725 - 86,239,202 (-)NCBI
Celera180,705,987 - 80,721,634 (-)NCBICelera
Cytogenetic Map1q21NCBI
Hpn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554684,384,630 - 4,400,379 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554684,384,630 - 4,399,881 (+)NCBIChiLan1.0ChiLan1.0
HPN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,052,919 - 41,079,073 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,035,320 - 43,062,410 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01931,985,761 - 32,012,841 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11940,725,315 - 40,750,628 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1940,725,319 - 40,750,628 (+)Ensemblpanpan1.1panPan2
HPN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,486,308 - 117,503,127 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,486,340 - 117,502,583 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,886,860 - 116,903,191 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01118,083,712 - 118,100,079 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1118,083,744 - 118,100,024 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11117,646,333 - 117,662,660 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01117,271,725 - 117,288,073 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01118,328,288 - 118,344,658 (-)NCBIUU_Cfam_GSD_1.0
Hpn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934910,458,113 - 10,474,937 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365701,170,943 - 1,186,500 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365701,170,951 - 1,186,501 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HPN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl644,608,071 - 44,628,049 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1644,608,076 - 44,628,044 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,033,553 - 40,101,145 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HPN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1629,973,743 - 29,998,701 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl629,973,867 - 29,998,855 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660737,743,680 - 7,768,279 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hpn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247948,421,791 - 8,439,782 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247948,426,005 - 8,439,758 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hpn
623 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1994
Count of miRNA genes:645
Interacting mature miRNAs:794
Transcripts:ENSMUST00000039435, ENSMUST00000108102, ENSMUST00000164340, ENSMUST00000164929, ENSMUST00000165124, ENSMUST00000165480, ENSMUST00000167719, ENSMUST00000168623, ENSMUST00000168884, ENSMUST00000171225, ENSMUST00000171259
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
7394747asp3_maudiogenic seizure prone 3 (mouse)Not determined72730579836842367Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse

Markers in Region
AI788568  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38731,099,056 - 31,099,322UniSTSGRCm38
MGSCv37731,884,075 - 31,884,341UniSTSGRCm37
Celera725,667,799 - 25,668,065UniSTS
Cytogenetic Map7B1UniSTS
Whitehead/MRC_RH7421.48UniSTS
AF030065  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38731,098,807 - 31,098,930UniSTSGRCm38
MGSCv37731,883,826 - 31,883,949UniSTSGRCm37
Celera725,667,550 - 25,667,673UniSTS
Cytogenetic Map7B1UniSTS
Whitehead/MRC_RH7426.55UniSTS
U85786  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38731,116,590 - 31,116,731UniSTSGRCm38
MGSCv37731,901,609 - 31,901,750UniSTSGRCm37
Celera725,685,819 - 25,685,960UniSTS
Cytogenetic Map7B1UniSTS
cM Map710.0UniSTS
Whitehead/MRC_RH7419.49UniSTS
RH124663  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38731,098,757 - 31,098,910UniSTSGRCm38
MGSCv37731,883,776 - 31,883,929UniSTSGRCm37
Celera725,667,500 - 25,667,653UniSTS
Cytogenetic Map7B1UniSTS
D1Bda14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38731,098,754 - 31,098,948UniSTSGRCm38
MGSCv37731,883,773 - 31,883,967UniSTSGRCm37
Celera725,667,497 - 25,667,691UniSTS
Cytogenetic Map7B1UniSTS
PMC15797P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38731,116,698 - 31,116,913UniSTSGRCm38
MGSCv37731,901,717 - 31,901,932UniSTSGRCm37
Celera725,685,927 - 25,686,142UniSTS
Cytogenetic Map7B1UniSTS
cM Map710.0UniSTS
Hpn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38731,098,980 - 31,099,054UniSTSGRCm38
MGSCv37731,883,999 - 31,884,073UniSTSGRCm37
Celera725,667,723 - 25,667,797UniSTS
Cytogenetic Map7B1UniSTS
cM Map7 UniSTS
Hpn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38731,099,035 - 31,099,896UniSTSGRCm38
MGSCv37731,884,054 - 31,884,915UniSTSGRCm37
Celera725,667,778 - 25,668,639UniSTS
Cytogenetic Map7B1UniSTS
Hpn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7B1UniSTS
Hpn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7B1UniSTS
Hpn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7B1UniSTS
cM Map7 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000039435   ⟹   ENSMUSP00000038149
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,798,150 - 30,810,422 (-)Ensembl
GRCm38.p6 Ensembl731,098,725 - 31,110,997 (-)Ensembl
RefSeq Acc Id: ENSMUST00000108102   ⟹   ENSMUSP00000103737
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,798,150 - 30,814,715 (-)Ensembl
GRCm38.p6 Ensembl731,098,725 - 31,115,290 (-)Ensembl
RefSeq Acc Id: ENSMUST00000164340
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,798,663 - 30,799,708 (-)Ensembl
GRCm38.p6 Ensembl731,099,238 - 31,100,283 (-)Ensembl
RefSeq Acc Id: ENSMUST00000164929   ⟹   ENSMUSP00000127229
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,808,565 - 30,811,383 (-)Ensembl
GRCm38.p6 Ensembl731,109,140 - 31,111,958 (-)Ensembl
RefSeq Acc Id: ENSMUST00000165124   ⟹   ENSMUSP00000145624
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,798,150 - 30,814,700 (-)Ensembl
GRCm38.p6 Ensembl731,098,725 - 31,115,275 (-)Ensembl
RefSeq Acc Id: ENSMUST00000165480
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,801,923 - 30,802,888 (-)Ensembl
GRCm38.p6 Ensembl731,102,498 - 31,103,463 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167719
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,801,618 - 30,802,615 (-)Ensembl
GRCm38.p6 Ensembl731,102,193 - 31,103,190 (-)Ensembl
RefSeq Acc Id: ENSMUST00000168623
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,809,991 - 30,810,434 (-)Ensembl
GRCm38.p6 Ensembl731,110,566 - 31,111,009 (-)Ensembl
RefSeq Acc Id: ENSMUST00000168884   ⟹   ENSMUSP00000131658
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,798,150 - 30,814,707 (-)Ensembl
GRCm38.p6 Ensembl731,098,725 - 31,115,282 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171225   ⟹   ENSMUSP00000130966
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,798,158 - 30,798,710 (-)Ensembl
GRCm38.p6 Ensembl731,098,733 - 31,099,285 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171259   ⟹   ENSMUSP00000132307
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,798,154 - 30,801,939 (-)Ensembl
GRCm38.p6 Ensembl731,098,729 - 31,102,514 (-)Ensembl
RefSeq Acc Id: NM_001110252   ⟹   NP_001103722
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39730,798,150 - 30,814,751 (-)NCBI
GRCm38731,098,725 - 31,115,326 (-)NCBI
MGSCv37731,883,744 - 31,900,309 (-)RGD
Celera725,667,468 - 25,684,556 (-)NCBI
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001276269   ⟹   NP_001263198
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39730,798,150 - 30,810,422 (-)NCBI
GRCm38731,098,725 - 31,110,997 (-)NCBI
Celera725,667,468 - 25,684,556 (-)NCBI
Sequence:
RefSeq Acc Id: NM_008281   ⟹   NP_032307
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39730,798,150 - 30,814,751 (-)NCBI
GRCm38731,098,725 - 31,115,326 (-)NCBI
MGSCv37731,883,744 - 31,900,309 (-)RGD
Celera725,667,468 - 25,684,556 (-)NCBI
cM Map7 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032307   ⟸   NM_008281
- Peptide Label: isoform 2 precursor
- UniProtKB: G3UWE8 (UniProtKB/TrEMBL),   Q3U0U6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103722   ⟸   NM_001110252
- Peptide Label: isoform 1 precursor
- UniProtKB: B2RSC4 (UniProtKB/Swiss-Prot),   Q9CW97 (UniProtKB/Swiss-Prot),   O35453 (UniProtKB/Swiss-Prot),   Q3U0U6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001263198   ⟸   NM_001276269
- Peptide Label: isoform 3 precursor
- UniProtKB: E9Q5P0 (UniProtKB/TrEMBL),   Q3U0U6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000127229   ⟸   ENSMUST00000164929
RefSeq Acc Id: ENSMUSP00000103737   ⟸   ENSMUST00000108102
RefSeq Acc Id: ENSMUSP00000130966   ⟸   ENSMUST00000171225
RefSeq Acc Id: ENSMUSP00000132307   ⟸   ENSMUST00000171259
RefSeq Acc Id: ENSMUSP00000145624   ⟸   ENSMUST00000165124
RefSeq Acc Id: ENSMUSP00000131658   ⟸   ENSMUST00000168884
RefSeq Acc Id: ENSMUSP00000038149   ⟸   ENSMUST00000039435
Protein Domains
Hepsin SRCR   Peptidase S1   SRCR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35453-F1-model_v2 AlphaFold O35453 1-436 view protein structure

Promoters
RGD ID:8663575
Promoter ID:EPDNEW_M9818
Type:multiple initiation site
Name:Hpn_2
Description:Mus musculus hepsin , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9819  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38731,111,011 - 31,111,071EPDNEW
RGD ID:8663577
Promoter ID:EPDNEW_M9819
Type:initiation region
Name:Hpn_1
Description:Mus musculus hepsin , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9818  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38731,115,294 - 31,115,354EPDNEW
RGD ID:6848149
Promoter ID:MM_ACW:44190
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:HPN.FSEP07,   HPN.ISEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36731,884,371 - 31,884,871 (-)MPROMDB
RGD ID:6849221
Promoter ID:MM_XEF:6496
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:NM_001126815
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36731,887,334 - 31,887,834 (-)MPROMDB
RGD ID:6848148
Promoter ID:MM_ACW:44191
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:HPN.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36731,888,334 - 31,888,834 (-)MPROMDB
RGD ID:6841288
Promoter ID:MM_KWN:49888
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:UC009GIB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36731,896,014 - 31,896,514 (-)MPROMDB
RGD ID:6841290
Promoter ID:MM_KWN:49889
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:NM_001110252,   NM_008281,   UC009GID.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36731,899,871 - 31,901,037 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1196620 AgrOrtholog
Ensembl Genes ENSMUSG00000001249 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000039435 ENTREZGENE
  ENSMUST00000039435.15 UniProtKB/TrEMBL
  ENSMUST00000108102 ENTREZGENE
  ENSMUST00000108102.9 UniProtKB/Swiss-Prot
  ENSMUST00000164929.3 UniProtKB/TrEMBL
  ENSMUST00000165124.8 UniProtKB/TrEMBL
  ENSMUST00000168884 ENTREZGENE
  ENSMUST00000168884.8 UniProtKB/TrEMBL
  ENSMUST00000171225.2 UniProtKB/TrEMBL
  ENSMUST00000171259.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Hepsin-SRCR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15451 UniProtKB/Swiss-Prot
MGD MGI:1196620 ENTREZGENE
NCBI Gene 15451 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HYALIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hepsin-SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hpn PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RNM3_MOUSE UniProtKB/TrEMBL
  B2RSC4 ENTREZGENE
  E9Q3X9_MOUSE UniProtKB/TrEMBL
  E9Q5P0 ENTREZGENE, UniProtKB/TrEMBL
  F6W6S4_MOUSE UniProtKB/TrEMBL
  F7C9T6_MOUSE UniProtKB/TrEMBL
  G3UWE8 ENTREZGENE, UniProtKB/TrEMBL
  HEPS_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U0U6 ENTREZGENE, UniProtKB/TrEMBL
  Q9CW97 ENTREZGENE
UniProt Secondary B2RSC4 UniProtKB/Swiss-Prot
  Q9CW97 UniProtKB/Swiss-Prot