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Gene: Sim2 (single-minded family bHLH transcription factor 2) Mus musculus
Symbol: Sim2
Name: single-minded family bHLH transcription factor 2
RGD ID: 1317541
Description: Exhibits DNA binding activity and protein heterodimerization activity. Involved in embryonic pattern specification; lung development; and negative regulation of transcription by RNA polymerase II. Localizes to nucleus. Is expressed in several structures, including ear; future brain; genitourinary system; musculoskeletal system; and respiratory system. Orthologous to human SIM2 (SIM bHLH transcription factor 2); INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bHLHe1; bHLHe15; mSIM; SIM transcription factor; single-minded 2; single-minded homolog 2; single-minded homolog 2 (Drosophila)
Homo sapiens (human) : SIM2 (SIM bHLH transcription factor 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sim2 (SIM bHLH transcription factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sim2 (SIM bHLH transcription factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SIM2 (SIM bHLH transcription factor 2)
Canis lupus familiaris (dog) : SIM2 (SIM bHLH transcription factor 2)
Sus scrofa (pig) : SIM2 (SIM bHLH transcription factor 2)
Chlorocebus sabaeus (African green monkey) : SIM2 (SIM bHLH transcription factor 2)
Heterocephalus glaber (naked mole-rat) : Sim2 (SIM bHLH transcription factor 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1694,084,931 - 94,127,032 (+)EnsemblGRCm38mm10GRCm38
GRCm381694,085,104 - 94,127,032 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371694,085,505 - 94,348,638 (+)NCBIGRCm37mm9NCBIm37
MGSCv361693,973,471 - 94,236,925 (+)NCBImm8
Celera1695,171,465 - 95,213,526 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1655.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Sim2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317541
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.