Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Thrap3 | Mouse | 1,2-dichloroethane | increases expression | EXP | | 6480464 | ethylene dichloride results in increased expression of THRAP3 mRNA | CTD | PMID:28960355 | Thrap3 | Mouse | 1,2-dimethylhydrazine | increases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of THRAP3 mRNA | CTD | PMID:22206623 | Thrap3 | Mouse | 17beta-estradiol | multiple interactions | ISO | THRAP3 (Homo sapiens) | 6480464 | Estradiol promotes the reaction [THRAP3 protein binds to ESR1 protein] | CTD | PMID:27156127 | Thrap3 | Mouse | 17beta-estradiol | decreases expression | ISO | Thrap3 (Rattus norvegicus) | 6480464 | Estradiol results in decreased expression of THRAP3 mRNA and Estradiol results in decreased expression of THRAP3 protein | CTD | PMID:32145629 | Thrap3 | Mouse | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | THRAP3 (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of THRAP3 mRNA | CTD | PMID:29581250 | Thrap3 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of THRAP3 mRNA | CTD | PMID:21570461 | Thrap3 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Thrap3 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of THRAP3 mRNA | CTD | PMID:34747641 | Thrap3 | Mouse | 4,4'-sulfonyldiphenol | increases expression | ISO | THRAP3 (Homo sapiens) | 6480464 | bisphenol S results in increased expression of THRAP3 protein | CTD | PMID:34186270 | Thrap3 | Mouse | 4,4'-sulfonyldiphenol | affects methylation | EXP | | 6480464 | bisphenol S affects the methylation of THRAP3 gene | CTD | PMID:31683443 | Thrap3 | Mouse | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of THRAP3 mRNA | CTD | PMID:28973697 | Thrap3 | Mouse | aconitine | decreases expression | ISO | Thrap3 (Rattus norvegicus) | 6480464 | Aconitine results in decreased expression of THRAP3 protein | CTD | PMID:33236894 | Thrap3 | Mouse | aflatoxin B1 | increases mutagenesis | ISO | Thrap3 (Rattus norvegicus) | 6480464 | Aflatoxin B1 results in increased mutagenesis of THRAP3 gene | CTD | PMID:36908029 | Thrap3 | Mouse | all-trans-retinoic acid | decreases expression | ISO | THRAP3 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of THRAP3 mRNA | CTD | PMID:21934132 | Thrap3 | Mouse | antirheumatic drug | decreases expression | ISO | THRAP3 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of THRAP3 mRNA | CTD | PMID:24449571 | Thrap3 | Mouse | aristolochic acid A | decreases expression | ISO | THRAP3 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of THRAP3 mRNA and aristolochic acid I results in decreased expression of THRAP3 protein | CTD | PMID:33212167 | Thrap3 | Mouse | benzo[a]pyrene | increases expression | ISO | Thrap3 (Rattus norvegicus) | 6480464 | Benzo(a)pyrene results in increased expression of THRAP3 mRNA | CTD | PMID:21839799 | Thrap3 | Mouse | benzo[a]pyrene | affects methylation | ISO | THRAP3 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of THRAP3 5' UTR | CTD | PMID:27901495 | Thrap3 | Mouse | benzo[a]pyrene | decreases methylation | ISO | THRAP3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of THRAP3 promoter | CTD | PMID:27901495 | Thrap3 | Mouse | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THRAP3 mRNA | CTD | PMID:27858113 | Thrap3 | Mouse | benzo[b]fluoranthene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THRAP3 mRNA | CTD | PMID:27858113 | Thrap3 | Mouse | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of THRAP3 mRNA | CTD | PMID:26063408 | Thrap3 | Mouse | bisphenol A | decreases expression | ISO | THRAP3 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of THRAP3 protein | CTD | PMID:34186270 | Thrap3 | Mouse | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of THRAP3 mRNA | CTD | PMID:33221593 | Thrap3 | Mouse | bisphenol A | decreases expression | ISO | Thrap3 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of THRAP3 mRNA and bisphenol A results in decreased expression of THRAP3 protein | CTD | PMID:32145629 | Thrap3 | Mouse | Bisphenol B | increases expression | ISO | THRAP3 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of THRAP3 protein | CTD | PMID:34186270 | Thrap3 | Mouse | bisphenol F | multiple interactions | ISO | THRAP3 (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in increased methylation of THRAP3 gene | CTD | PMID:31601247 | Thrap3 | Mouse | cadmium dichloride | increases expression | ISO | Thrap3 (Rattus norvegicus) | 6480464 | Cadmium Chloride results in increased expression of THRAP3 mRNA | CTD | PMID:21297351 | Thrap3 | Mouse | caffeine | affects phosphorylation | ISO | THRAP3 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of THRAP3 protein | CTD | PMID:35688186 | Thrap3 | Mouse | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Thrap3 | Mouse | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of THRAP3 mRNA | CTD | PMID:37019170 | Thrap3 | Mouse | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of THRAP3 gene | CTD | PMID:20938992 | Thrap3 | Mouse | chrysene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THRAP3 mRNA | CTD | PMID:27858113 | Thrap3 | Mouse | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of THRAP3 mRNA | CTD | PMID:17585979 | Thrap3 | Mouse | clozapine | decreases expression | ISO | THRAP3 (Homo sapiens) | 6480464 | Clozapine results in decreased expression of THRAP3 protein | CTD | PMID:34122009 | Thrap3 | Mouse | coumarin | affects phosphorylation | ISO | THRAP3 (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of THRAP3 protein | CTD | PMID:35688186 | Thrap3 | Mouse | crocidolite asbestos | affects expression | ISO | THRAP3 (Homo sapiens) | 6480464 | Asbestos and Crocidolite affects the expression of THRAP3 mRNA | CTD | PMID:17331233 | Thrap3 | Mouse | deoxynivalenol | increases phosphorylation | EXP | | 6480464 | deoxynivalenol results in increased phosphorylation of THRAP3 protein | CTD | PMID:23352502 and PMID:23811945 | Thrap3 | Mouse | dibenzo[a,l]pyrene | increases expression | EXP | | 6480464 | dibenzo(a and l)pyrene results in increased expression of THRAP3 mRNA | CTD | PMID:25908611 | Thrap3 | Mouse | enzyme inhibitor | multiple interactions | ISO | THRAP3 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of THRAP3 protein | CTD | PMID:23301498 | Thrap3 | Mouse | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of THRAP3 mRNA | CTD | PMID:30319688 | Thrap3 | Mouse | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of THRAP3 gene | CTD | PMID:20938992 | Thrap3 | Mouse | FR900359 | affects phosphorylation | ISO | THRAP3 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of THRAP3 protein | CTD | PMID:37730182 | Thrap3 | Mouse | fulvestrant | multiple interactions | ISO | THRAP3 (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in increased methylation of THRAP3 gene | CTD | PMID:31601247 | Thrap3 | Mouse | hydralazine | multiple interactions | ISO | THRAP3 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of THRAP3 mRNA | CTD | PMID:17183730 | Thrap3 | Mouse | hydrogen peroxide | increases phosphorylation | EXP | | 6480464 | Hydrogen Peroxide results in increased phosphorylation of THRAP3 protein | CTD | PMID:31494107 | Thrap3 | Mouse | hydrogen peroxide | multiple interactions | EXP | | 6480464 | N-(oxo-5 more ... | CTD | PMID:31494107 | Thrap3 | Mouse | irinotecan | decreases expression | ISO | THRAP3 (Homo sapiens) | 6480464 | Irinotecan analog results in decreased expression of THRAP3 mRNA | CTD | PMID:18927307 | Thrap3 | Mouse | ivermectin | decreases expression | ISO | THRAP3 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of THRAP3 protein | CTD | PMID:32959892 | Thrap3 | Mouse | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of THRAP3 gene | CTD | PMID:20938992 | Thrap3 | Mouse | Mesaconitine | increases expression | ISO | Thrap3 (Rattus norvegicus) | 6480464 | mesaconitine results in increased expression of THRAP3 protein | CTD | PMID:37182599 | Thrap3 | Mouse | methylparaben | increases expression | ISO | THRAP3 (Homo sapiens) | 6480464 | methylparaben results in increased expression of THRAP3 mRNA | CTD | PMID:31745603 | Thrap3 | Mouse | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of THRAP3 mRNA | CTD | PMID:24381131 | Thrap3 | Mouse | paracetamol | decreases expression | ISO | Thrap3 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of THRAP3 mRNA | CTD | PMID:33387578 | Thrap3 | Mouse | perfluorohexanesulfonic acid | decreases expression | EXP | | 6480464 | perfluorohexanesulfonic acid results in decreased expression of THRAP3 mRNA | CTD | PMID:37995155 | Thrap3 | Mouse | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of THRAP3 mRNA | CTD | PMID:23091169 | Thrap3 | Mouse | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of THRAP3 mRNA | CTD | PMID:16985257 | Thrap3 | Mouse | propiconazole | decreases expression | EXP | | 6480464 | propiconazole results in decreased expression of THRAP3 mRNA | CTD | PMID:21278054 | Thrap3 | Mouse | resveratrol | multiple interactions | ISO | THRAP3 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of THRAP3 mRNA | CTD | PMID:23557933 | Thrap3 | Mouse | sodium arsenate | increases expression | EXP | | 6480464 | sodium arsenate results in increased expression of THRAP3 mRNA | CTD | PMID:21795629 | Thrap3 | Mouse | sodium arsenite | decreases expression | ISO | THRAP3 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of THRAP3 mRNA | CTD | PMID:38568856 | Thrap3 | Mouse | Soman | decreases expression | ISO | Thrap3 (Rattus norvegicus) | 6480464 | Soman results in decreased expression of THRAP3 mRNA | CTD | PMID:19281266 | Thrap3 | Mouse | sunitinib | increases expression | ISO | THRAP3 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of THRAP3 mRNA | CTD | PMID:31533062 | Thrap3 | Mouse | temozolomide | increases expression | ISO | THRAP3 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of THRAP3 mRNA | CTD | PMID:31758290 | Thrap3 | Mouse | tetraphene | decreases expression | EXP | | 6480464 | benz(a)anthracene results in decreased expression of THRAP3 mRNA | CTD | PMID:26377693 | Thrap3 | Mouse | tetraphene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THRAP3 mRNA | CTD | PMID:27858113 | Thrap3 | Mouse | thimerosal | decreases expression | ISO | THRAP3 (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of THRAP3 mRNA | CTD | PMID:27188386 | Thrap3 | Mouse | titanium dioxide | decreases methylation | EXP | | 6480464 | titanium dioxide results in decreased methylation of THRAP3 gene | CTD | PMID:35295148 | Thrap3 | Mouse | trichloroethene | decreases expression | ISO | Thrap3 (Rattus norvegicus) | 6480464 | Trichloroethylene results in decreased expression of THRAP3 mRNA | CTD | PMID:33387578 | Thrap3 | Mouse | triptonide | affects expression | EXP | | 6480464 | triptonide affects the expression of THRAP3 mRNA | CTD | PMID:33045310 | Thrap3 | Mouse | troglitazone | decreases expression | EXP | | 6480464 | troglitazone results in decreased expression of THRAP3 mRNA | CTD | PMID:28973697 | Thrap3 | Mouse | trovafloxacin | multiple interactions | EXP | | 6480464 | [trovafloxacin co-treated with lipopolysaccharide and E coli O55-B5] results in increased expression of THRAP3 mRNA | CTD | PMID:18930950 | Thrap3 | Mouse | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of THRAP3 mRNA | CTD | PMID:30912803 | Thrap3 | Mouse | valproic acid | multiple interactions | ISO | THRAP3 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of THRAP3 mRNA | CTD | PMID:17183730 | Thrap3 | Mouse | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid analog results in decreased expression of THRAP3 mRNA and Valproic Acid results in decreased expression of THRAP3 mRNA | CTD | PMID:21427059 | Thrap3 | Mouse | vorinostat | decreases expression | ISO | THRAP3 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of THRAP3 mRNA | CTD | PMID:27188386 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 2. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 3. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:10349636 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:12093747 | PMID:12433684 | PMID:12466851 | PMID:12477932 | PMID:12520002 | PMID:12904583 | PMID:14610273 |
| PMID:15226823 | PMID:15340084 | PMID:15489334 | PMID:15582152 | PMID:15782199 | PMID:16107646 | PMID:16141072 | PMID:16141073 | PMID:16452087 | PMID:16602821 | PMID:17967808 | PMID:18287559 |
| PMID:18799693 | PMID:20059953 | PMID:20064376 | PMID:21267068 | PMID:21565611 | PMID:21677750 | PMID:21779340 | PMID:21873635 | PMID:23525231 | PMID:24043798 | PMID:24457600 | PMID:25316675 |
| PMID:25859222 | PMID:26370502 | PMID:28378742 | PMID:28671696 | PMID:28770354 | PMID:28784777 | PMID:29459677 | PMID:30409884 | PMID:30457570 | PMID:31138677 | PMID:35012549 | PMID:36417873 |
| PMID:37142655 | PMID:37253089 | PMID:37524868 | PMID:37549548 |
Genomics
Comparative Map Data
| Thrap3 (Mus musculus - house mouse) |
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| THRAP3 (Homo sapiens - human) |
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| Thrap3 (Rattus norvegicus - Norway rat) |
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| Thrap3 (Chinchilla lanigera - long-tailed chinchilla) |
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| THRAP3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| THRAP3 (Canis lupus familiaris - dog) |
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| Thrap3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| THRAP3 (Sus scrofa - pig) |
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| THRAP3 (Chlorocebus sabaeus - green monkey) |
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| Thrap3 (Heterocephalus glaber - naked mole-rat) |
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miRNA Target Status
Predicted Target Of
| The detailed report is available here: |  | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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QTLs in Region (GRCm39)
| The following QTLs overlap with this region. | | Full Report | | CSV | | TAB | | Printer | | Gviewer |
