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Gene: Cttn (cortactin) Mus musculus
Symbol: Cttn
Name: cortactin
Description: Predicted to have several functions, including Arp2/3 complex binding activity; actin filament binding activity; and profilin binding activity. Involved in several processes, including dendritic spine maintenance; negative regulation of extrinsic apoptotic signaling pathway; and substrate-dependent cell migration, cell extension. Localizes to several cellular components, including the cytoskeleton; lamellipodium; and ruffle. Colocalizes with the voltage-gated potassium channel complex. Is expressed in several structures, including 1-cell stage conceptus; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human CTTN (cortactin); PARTICIPATES IN E-cadherin signaling pathway; fibroblast growth factor signaling pathway; N-cadherin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110020L01Rik; Ems1; mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); src substrate cortactin
Homo sapiens (human) : CTTN (cortactin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cttn (cortactin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cttn (cortactin)
Pan paniscus (bonobo/pygmy chimpanzee) : CTTN (cortactin)
Canis lupus familiaris (dog) : CTTN (cortactin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cttn (cortactin)
Sus scrofa (pig) : CTTN (cortactin)
Chlorocebus sabaeus (green monkey) : CTTN (cortactin)
Heterocephalus glaber (naked mole-rat) : Cttn (cortactin)
more info ...
Related Pseudogenes: Gm4873   Gm5310  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl7144,435,733 - 144,471,009 (-)Ensembl
GRCm387144,435,724 - 144,471,560 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377151,621,629 - 151,656,646 (-)NCBIGRCm37mm9NCBIm37
MGSCv367144,245,114 - 144,280,131 (-)NCBImm8
Celera7144,198,389 - 144,233,617 (-)NCBICelera
Cytogenetic Map7 F5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cttn
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731566
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.