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Gene: Cttn (cortactin) Mus musculus
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Symbol: Cttn
Name: cortactin
Description: Predicted to have several functions, including Arp2/3 complex binding activity; actin filament binding activity; and profilin binding activity. Involved in several processes, including dendritic spine maintenance; negative regulation of extrinsic apoptotic signaling pathway; and substrate-dependent cell migration, cell extension. Localizes to several cellular components, including the cytoskeleton; lamellipodium; and ruffle. Colocalizes with the voltage-gated potassium channel complex. Is expressed in several structures, including 1-cell stage conceptus; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human CTTN (cortactin); PARTICIPATES IN E-cadherin signaling pathway; fibroblast growth factor signaling pathway; N-cadherin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110020L01Rik; Ems1; mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); src substrate cortactin
Orthologs:
Homo sapiens (human) : CTTN (cortactin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cttn (cortactin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cttn (cortactin)
Pan paniscus (bonobo/pygmy chimpanzee) : CTTN (cortactin)
Canis lupus familiaris (dog) : CTTN (cortactin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cttn (cortactin)
Sus scrofa (pig) : CTTN (cortactin)
Chlorocebus sabaeus (green monkey) : CTTN (cortactin)
Heterocephalus glaber (naked mole-rat) : Cttn (cortactin)
more info ...
Related Pseudogenes: Gm4873   Gm5310  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl7144,435,733 - 144,471,009 (-)Ensembl
GRCm387144,435,724 - 144,471,560 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377151,621,629 - 151,656,646 (-)NCBIGRCm37mm9NCBIm37
MGSCv367144,245,114 - 144,280,131 (-)NCBImm8
Celera7144,198,389 - 144,233,617 (-)NCBICelera
Cytogenetic Map7 F5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cttn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731566
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.