Oxt (oxytocin) - Rat Genome Database
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Gene: Oxt (oxytocin) Mus musculus
Analyze
Symbol: Oxt
Name: oxytocin
RGD ID: 11040
MGI Page MGI
Description: Is expressed in brain. Orthologous to human OXT (oxytocin/neurophysin I prepropeptide).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: neurophysin 1; OT; OT-NPI; Ox; Oxy; oxytocin-neurophysin 1
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392130,416,432 - 130,418,974 (+)NCBIGRCm39mm39
GRCm39 Ensembl2130,418,093 - 130,418,974 (+)Ensembl
GRCm382130,574,519 - 130,577,054 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2130,576,173 - 130,577,054 (+)EnsemblGRCm38mm10GRCm38
MGSCv372130,401,909 - 130,402,724 (+)NCBIGRCm37mm9NCBIm37
MGSCv362130,267,614 - 130,268,429 (+)NCBImm8
Celera2131,800,597 - 131,801,412 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
drinking behavior  (ISO)
eating behavior  (ISO)
female pregnancy  (ISO)
grooming behavior  (ISO)
heart development  (ISO)
hyperosmotic salinity response  (ISO)
male mating behavior  (ISO)
maternal aggressive behavior  (ISO)
maternal behavior  (ISO)
memory  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of gastric acid secretion  (ISO)
negative regulation of urine volume  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of female receptivity  (ISO)
positive regulation of hindgut contraction  (ISO)
positive regulation of norepinephrine secretion  (ISO)
positive regulation of ossification  (ISO)
positive regulation of penile erection  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of renal sodium excretion  (ISO)
positive regulation of synapse assembly  (ISO)
positive regulation of synaptic transmission  (ISO)
positive regulation of uterine smooth muscle contraction  (ISO)
regulation of digestive system process  (ISO)
regulation of heart rate  (ISO)
regulation of sensory perception of pain  (ISO)
response to activity  (ISO)
response to amphetamine  (ISO)
response to cAMP  (ISO)
response to cocaine  (ISO)
response to electrical stimulus  (ISO)
response to estradiol  (ISO)
response to ether  (ISO)
response to food  (ISO)
response to glucocorticoid  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to progesterone  (ISO)
response to prostaglandin E  (ISO)
response to retinoic acid  (ISO)
response to steroid hormone  (ISO)
response to sucrose  (ISO)
sleep  (ISO)
social behavior  (ISO)
sperm ejaculation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:2176709   PMID:7830793   PMID:8432536   PMID:8543156   PMID:8863731   PMID:8876199   PMID:8889548   PMID:8933362   PMID:9118797   PMID:9181490   PMID:9678638   PMID:9751758  
PMID:9784500   PMID:9924185   PMID:10026810   PMID:10195900   PMID:10349636   PMID:10557207   PMID:10753584   PMID:10888874   PMID:10956266   PMID:11042159   PMID:11071765   PMID:11076861  
PMID:11089561   PMID:11318878   PMID:11471062   PMID:11573985   PMID:11588199   PMID:11641104   PMID:11869373   PMID:11956346   PMID:12093924   PMID:12124945   PMID:12383972   PMID:12477932  
PMID:12508235   PMID:12531518   PMID:12531722   PMID:12730370   PMID:12746288   PMID:12834440   PMID:12907752   PMID:12944509   PMID:12953013   PMID:12953788   PMID:14557235   PMID:14962074  
PMID:14988428   PMID:15089969   PMID:15112106   PMID:15184356   PMID:15307217   PMID:15319220   PMID:15718385   PMID:15924555   PMID:15964694   PMID:16141072   PMID:16141073   PMID:16150836  
PMID:16168966   PMID:16249339   PMID:16374801   PMID:16537524   PMID:16594980   PMID:16602821   PMID:16677726   PMID:16930592   PMID:17010099   PMID:17272659   PMID:17287729   PMID:17356169  
PMID:17420046   PMID:17433558   PMID:17504245   PMID:17596329   PMID:17895964   PMID:17947352   PMID:18063939   PMID:18071238   PMID:18451093   PMID:18625285   PMID:18926879   PMID:19120108  
PMID:19228979   PMID:19247273   PMID:19369205   PMID:19531157   PMID:19653998   PMID:19675071   PMID:19695304   PMID:19889866   PMID:20092567   PMID:20495559   PMID:20554879   PMID:20685878  
PMID:20700536   PMID:20732312   PMID:20876615   PMID:20969650   PMID:21046478   PMID:21048978   PMID:21139074   PMID:21247964   PMID:21439349   PMID:21514276   PMID:21741363   PMID:21832120  
PMID:21873635   PMID:22079582   PMID:22107910   PMID:22227279   PMID:22262306   PMID:22761429   PMID:22784207   PMID:22865874   PMID:22945632   PMID:22950040   PMID:23028821   PMID:23376700  
PMID:23403283   PMID:23441222   PMID:23674600   PMID:23906766   PMID:24025838   PMID:24059452   PMID:24205344   PMID:24464043   PMID:24487620   PMID:24893201   PMID:24915299   PMID:24952961  
PMID:25071457   PMID:25157144   PMID:25392498   PMID:25605713   PMID:25863961   PMID:25864637   PMID:25874674   PMID:25915476   PMID:25943916   PMID:26139372   PMID:26163772   PMID:26375004  
PMID:26611327   PMID:26635729   PMID:26911697   PMID:26926566   PMID:27059771   PMID:27143105   PMID:27187722   PMID:27558735   PMID:28228269   PMID:28288114   PMID:28625488   PMID:28654087  
PMID:28669546   PMID:28715127   PMID:28801574   PMID:28807898   PMID:28889007   PMID:28912554   PMID:28963257   PMID:29056294   PMID:29184212   PMID:29186377   PMID:29231812   PMID:29277701  
PMID:29676731   PMID:29688375   PMID:29991705   PMID:30076862   PMID:30192229   PMID:30240706   PMID:30293821   PMID:30389922   PMID:30472090   PMID:30545636   PMID:30756300   PMID:30820471  
PMID:31781038   PMID:32024781   PMID:32325033   PMID:32640184   PMID:32760004   PMID:33113347  


Genomics

Comparative Map Data
Oxt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392130,416,432 - 130,418,974 (+)NCBIGRCm39mm39
GRCm39 Ensembl2130,418,093 - 130,418,974 (+)Ensembl
GRCm382130,574,519 - 130,577,054 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2130,576,173 - 130,577,054 (+)EnsemblGRCm38mm10GRCm38
MGSCv372130,401,909 - 130,402,724 (+)NCBIGRCm37mm9NCBIm37
MGSCv362130,267,614 - 130,268,429 (+)NCBImm8
Celera2131,800,597 - 131,801,412 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.24NCBI
OXT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl203,071,620 - 3,072,517 (+)EnsemblGRCh38hg38GRCh38
GRCh38203,068,871 - 3,072,517 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37203,052,266 - 3,053,163 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,000,266 - 3,001,162 (+)NCBINCBI36hg18NCBI36
Build 34203,000,265 - 3,001,162NCBI
Celera203,114,251 - 3,115,147 (+)NCBI
Cytogenetic Map20p13NCBI
HuRef202,998,607 - 2,999,505 (+)NCBIHuRef
CHM1_1203,046,806 - 3,047,704 (+)NCBICHM1_1
Oxt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23117,782,650 - 117,783,490 (+)NCBI
Rnor_6.0 Ensembl3123,106,694 - 123,107,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03123,106,694 - 123,107,534 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03129,604,822 - 129,605,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,194,219 - 118,195,056 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13118,097,303 - 118,100,512 (+)NCBI
Celera3116,593,509 - 116,594,349 (+)NCBICelera
Cytogenetic Map3q36NCBI
OXT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v0203,157,246 - 3,159,013 (+)NCBIMhudiblu_PPA_v0panPan3
OXT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2418,193,339 - 18,194,170 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12418,193,381 - 18,194,232 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
OXT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1732,605,588 - 32,606,483 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11732,605,586 - 32,606,449 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,975,726 - 36,976,589 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OXT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1233,749,520 - 33,750,981 (+)NCBI
ChlSab1.1 Ensembl233,750,108 - 33,750,968 (+)Ensembl
Oxt
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247414,200,594 - 4,201,416 (+)NCBI

Position Markers
UniSTS:492254  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382130,576,190 - 130,576,971UniSTSGRCm38
MGSCv372130,401,926 - 130,402,707UniSTSGRCm37
Celera2131,800,614 - 131,801,395UniSTS
Cytogenetic Map2F1UniSTS
cM Map273.5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245457623145470727Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)262000000137000000Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284182854148680255Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284182854148825550Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294400000154400000Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297292889131293051Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297292889131293051Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297379883131379883Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297379883131379883Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100993579134993788Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2101112449135112609Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2101112449135112609Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2101112449135112609Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102800000160100000Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103265371167370436Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106391660140391809Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107413756141413756Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110647738144647887Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2111085773154512747Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111331784145331901Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111331784145331901Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111331784145331901Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111331784145331901Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111709108145709243Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111781466145781606Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112370826146371085Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112370826146371085Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112370826146371085Mouse
1301029T2dm3_mtype 2 diabetes mellitus 3 (mouse)Not determined2114457594132872237Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115370937149371074Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115370937149371074Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116235703150235821Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116464410150464554Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2118112449174483070Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118758772160769245Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118758772160769245Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118758772160769245Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118758772160769245Mouse
1300712El2_mepilepsy 2 (mouse)Not determined2122376665142690215Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2123041095157041211Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123390053148858457Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2124095391158095504Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124600000168400000Mouse
13506763Tbvq1_mtrabecular bone volume QTL 1 (mouse)2126200000135600000Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127822099161822198Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127822099161822198Mouse
1558989Gnf4_mgrowth and fatness 4 (mouse)Not determined2128331784132872237Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129500000163500000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:89
Interacting mature miRNAs:89
Transcripts:ENSMUST00000028764
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000028764   ⟹   ENSMUSP00000028764
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2130,576,173 - 130,577,054 (+)Ensembl
RefSeq Acc Id: NM_011025   ⟹   NP_035155
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392130,418,089 - 130,418,974 (+)NCBI
GRCm382130,576,169 - 130,577,054 (+)NCBI
MGSCv372130,401,909 - 130,402,724 (+)RGD
Celera2131,800,593 - 131,801,478 (+)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006498910   ⟹   XP_006498973
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392130,416,432 - 130,418,788 (+)NCBI
GRCm382130,574,519 - 130,576,868 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035155   ⟸   NM_011025
- Peptide Label: preproprotein
- UniProtKB: P35454 (UniProtKB/Swiss-Prot),   Q545V4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006498973   ⟸   XM_006498910
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000028764   ⟸   ENSMUST00000028764

Promoters
RGD ID:6878760
Promoter ID:EPDNEW_M2831
Type:single initiation site
Name:Oxt_1
Description:Mus musculus oxytocin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382130,576,173 - 130,576,233EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97453 AgrOrtholog
Ensembl Genes ENSMUSG00000027301 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000028764 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028764 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.9.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Neurhyp_horm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurhyp_horm_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurohypophysial_hormone_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18429 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97453 ENTREZGENE
NCBI Gene 18429 ENTREZGENE
PANTHER PTHR11681 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hormone_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Oxt PhenoGen
PIRSF Nonapeptide_hormone_precursor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS NEUROPHYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROHYPOPHYS_HORM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt I3PGM0_MOUSE UniProtKB/TrEMBL
  I3PGM1_MOUSE UniProtKB/TrEMBL
  NEU1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q545V4 ENTREZGENE, UniProtKB/TrEMBL