Gene: Abce1 (ATP-binding cassette, sub-family E (OABP), member 1) Mus musculus
Analyze
Symbol:
Abce1
Name:
ATP-binding cassette, sub-family E (OABP), member 1
Description:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. [provided by RefSeq, Jul 2008]
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
ATP-binding cassette sub-family E member 1; ATP-binding cassette, subfamily E, member 1; C79080; Oabp; ribonuclease 4 inhibitor; ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) inhibitor; RLI; RNase L inhibitor; Rnaseli; RNS41; RNS4I; RNS4l (Eye)
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ABCE1 (ATP binding cassette subfamily E member 1) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Abce1 (ATP binding cassette subfamily E member 1) HGNC
Treefam, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Abce1 (ATP binding cassette subfamily E member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ABCE1 (ATP binding cassette subfamily E member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ABCE1 (ATP binding cassette subfamily E member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Abce1 (ATP binding cassette subfamily E member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ABCE1 (ATP binding cassette subfamily E member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Abce1 (ATP binding cassette subfamily E member 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
ABCE1 (ATP binding cassette subfamily E member 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
abce1 (ATP-binding cassette, sub-family E (OABP), member 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Saccharomyces cerevisiae (baker's yeast):
RLI1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
abce-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Drosophila melanogaster (fruit fly):
pix
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Related Pseudogenes:
Gm19061
Gm6640
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 8 79,683,442 - 79,711,740 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 8 82,207,341 - 82,235,639 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 8 82,579,717 - 82,607,693 (-) NCBI mm8 Celera 8 83,959,260 - 83,987,564 (-) NCBI Celera Cytogenetic Map 8 C1 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
prostate cancer ISO RGD:1313249 8554872 ClinVar Annotator: match by term: Prostate cancer ClinVar PMID:23265383
Imported Annotations - CTD
Colorectal Neoplasms ISO RGD:1313249 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22294766
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1313249 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ABCE1 mRNA CTD PMID:22079256 1-nitropyrene increases expression ISO RGD:1313249 6480464 1-nitropyrene results in increased expression of ABCE1 mRNA CTD PMID:19041380 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ABCE1 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:1313249 6480464 EGF protein promotes the reaction [Estradiol results in increased expression of ABCE1 mRNA] CTD PMID:24758408 17beta-estradiol increases expression ISO RGD:1313249 6480464 Estradiol results in increased expression of ABCE1 mRNA CTD PMID:24758408 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ABCE1 mRNA, AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ABCE1 mRNA] CTD PMID:15034205 , PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of ABCE1 mRNA CTD PMID:15034205 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of ABCE1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1313249 6480464 Tetrachlorodibenzodioxin affects the expression of ABCE1 mRNA CTD PMID:22298810 2,4-dinitrotoluene affects expression ISO RGD:1305301 6480464 2, 4-dinitrotoluene affects the expression of ABCE1 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:1305301 6480464 2, 6-dinitrotoluene affects the expression of ABCE1 mRNA CTD PMID:21346803 2-methylcholine affects expression ISO RGD:1313249 6480464 beta-methylcholine affects the expression of ABCE1 mRNA CTD PMID:21179406 4-amino-2,6-dinitrotoluene affects expression ISO RGD:1305301 6480464 4-amino-2, 6-dinitrotoluene affects the expression of ABCE1 mRNA CTD PMID:21346803 all-trans-retinoic acid multiple interactions ISO RGD:1313249 6480464 Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of ABCE1 mRNA] CTD PMID:16140955 all-trans-retinoic acid decreases expression ISO RGD:1313249 6480464 Tretinoin results in decreased expression of ABCE1 mRNA CTD PMID:16140955 , PMID:23724009 antirheumatic drug decreases expression ISO RGD:1313249 6480464 Antirheumatic Agents results in decreased expression of ABCE1 mRNA CTD PMID:24449571 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of ABCE1 mRNA CTD PMID:23650126 atrazine decreases expression ISO RGD:1313249 6480464 Atrazine results in decreased expression of ABCE1 mRNA CTD PMID:22378314 benzo[a]pyrene multiple interactions EXP 6480464 AHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ABCE1 mRNA] CTD PMID:15034205 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of ABCE1 mRNA CTD PMID:15034205 , PMID:22228805 bisphenol A increases expression ISO RGD:1305301 6480464 bisphenol A results in increased expression of ABCE1 mRNA CTD PMID:25181051 C60 fullerene decreases expression ISO RGD:1305301 6480464 fullerene C60 results in decreased expression of ABCE1 mRNA CTD PMID:19167457 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon results in increased expression of ABCE1 mRNA CTD PMID:25554681 chromium(6+) affects expression EXP 6480464 chromium hexavalent ion affects the expression of ABCE1 mRNA CTD PMID:28472532 cisplatin multiple interactions ISO RGD:1313249 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of ABCE1 mRNA CTD PMID:27392435 coumestrol increases expression ISO RGD:1313249 6480464 Coumestrol results in increased expression of ABCE1 mRNA CTD PMID:19167446 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of ABCE1 mRNA CTD PMID:19770486 dicrotophos decreases expression ISO RGD:1313249 6480464 dicrotophos results in decreased expression of ABCE1 mRNA CTD PMID:28302478 doxorubicin decreases expression ISO RGD:1313249 6480464 Doxorubicin results in decreased expression of ABCE1 mRNA CTD PMID:29803840 enzyme inhibitor multiple interactions ISO RGD:1313249 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ABCE1 protein CTD PMID:23301498 ethyl methanesulfonate decreases expression ISO RGD:1313249 6480464 Ethyl Methanesulfonate results in decreased expression of ABCE1 mRNA CTD PMID:23649840 finasteride increases expression ISO RGD:1305301 6480464 Finasteride results in increased expression of ABCE1 mRNA CTD PMID:24136188 flutamide increases expression ISO RGD:1305301 6480464 Flutamide results in increased expression of ABCE1 mRNA CTD PMID:24136188 gentamycin increases expression ISO RGD:1305301 6480464 Gentamicins results in increased expression of ABCE1 mRNA CTD PMID:22061828 hexadecanoic acid increases expression ISO RGD:1313249 6480464 Palmitic Acid results in increased expression of ABCE1 protein CTD PMID:24651439 lead diacetate increases expression ISO RGD:1305301 6480464 lead acetate results in increased expression of ABCE1 mRNA CTD PMID:11578147 methapyrilene decreases expression ISO RGD:1305301 6480464 Methapyrilene results in decreased expression of ABCE1 mRNA CTD PMID:30467583 methyl methanesulfonate decreases expression ISO RGD:1313249 6480464 Methyl Methanesulfonate results in decreased expression of ABCE1 mRNA CTD PMID:23649840 N-nitrosodiethylamine multiple interactions ISO RGD:1305301 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of ABCE1 mRNA, [Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of ABCE1 promoter CTD PMID:25374375 nefazodone increases expression ISO RGD:1305301 6480464 nefazodone results in increased expression of ABCE1 mRNA CTD PMID:24136188 nimesulide increases expression ISO RGD:1305301 6480464 nimesulide results in increased expression of ABCE1 mRNA CTD PMID:24136188 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of ABCE1 mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:1313249 6480464 Acetaminophen results in decreased expression of ABCE1 mRNA CTD PMID:21420995 , PMID:25704631 phenobarbital multiple interactions ISO RGD:1305301 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of ABCE1 mRNA, [Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of ABCE1 promoter CTD PMID:25374375 pinosylvin decreases expression ISO RGD:1313249 6480464 pinosylvin results in decreased expression of ABCE1 mRNA CTD PMID:23333577 potassium chromate decreases expression ISO RGD:1313249 6480464 potassium chromate(VI) results in decreased expression of ABCE1 mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:1313249 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ABCE1 mRNA CTD PMID:22079256 propiconazole increases expression EXP 6480464 propiconazole results in increased expression of ABCE1 mRNA CTD PMID:21278054 silicon dioxide increases expression ISO RGD:1313249 6480464 Silicon Dioxide analog results in increased expression of ABCE1 mRNA CTD PMID:25895662 succimer multiple interactions ISO RGD:1313249 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ABCE1 mRNA CTD PMID:26378955 succimer multiple interactions EXP 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ABCE1 mRNA CTD PMID:26378955 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of ABCE1 mRNA CTD PMID:17484886 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of ABCE1 mRNA CTD PMID:27339419 thiophenes multiple interactions ISO RGD:1313249 6480464 Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of ABCE1 mRNA] CTD PMID:16140955 trans-pinosylvin decreases expression ISO RGD:1313249 6480464 pinosylvin results in decreased expression of ABCE1 mRNA CTD PMID:23333577 tunicamycin increases expression EXP 6480464 Tunicamycin results in increased expression of ABCE1 mRNA CTD PMID:17127020 urethane decreases expression ISO RGD:1313249 6480464 Urethane results in decreased expression of ABCE1 mRNA CTD PMID:28818685 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of ABCE1 mRNA CTD PMID:17292431 valproic acid decreases expression ISO RGD:1313249 6480464 Valproic Acid results in decreased expression of ABCE1 mRNA CTD PMID:23179753 , PMID:27188386 vinclozolin increases expression ISO RGD:1305301 6480464 vinclozolin results in increased expression of ABCE1 mRNA CTD PMID:23555832
Gene-Chemical Interaction Annotations
