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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-methylpiperazine
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Accession:CHEBI:46920 term browser browse the term
Synonyms:related_synonym: N-methylpiperazines

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2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO bisbenzimide ethoxide trihydrochloride inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions		 ISO ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride
ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride
abamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
abamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]		 CTD PMID:25865432 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
increases transport		 ISO abamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride] CTD PMID:25865432 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases abundance
decreases export
decreases activity
multiple interactions
increases export
increases transport		 ISO ABCG2 protein results in decreased abundance of bisbenzimide ethoxide trihydrochloride
ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride
bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCG2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; [MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride; Cimetidine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; danofloxacin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein promotes the reaction [ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride]; Methotrexate inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Tobacco Smoke Pollution inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; verlukast inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]		 CTD PMID:12869632, PMID:19239227, PMID:26850786, PMID:26907376, PMID:27450509, PMID:27475308 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases export ISO KEAP1 protein results in decreased export of bisbenzimide ethoxide trihydrochloride CTD PMID:25841332 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride CTD PMID:19239227 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
bosutinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase decreases activity ISO bosutinib results in decreased activity of ABL1 protein CTD PMID:17114238 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
decreases expression		 ISO bosutinib results in decreased phosphorylation of AKT1 protein
bosutinib results in decreased expression of AKT1 protein		 CTD PMID:17129604 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO bosutinib results in decreased expression of CCND1 protein
[SM 164 co-treated with bosutinib] results in decreased expression of CCND1 protein		 CTD PMID:16489032, PMID:22241084 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccnd3 cyclin D3 affects localization
multiple interactions		 ISO bosutinib affects the localization of CCND3 protein
[bosutinib co-treated with Imatinib Mesylate] affects the localization of CCND3 protein		 CTD PMID:17129604 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943 		JBrowse link
G Cdc25a cell division cycle 25A decreases expression
multiple interactions		 ISO bosutinib results in decreased expression of CDC25A protein
Imatinib Mesylate promotes the reaction [bosutinib results in decreased expression of CDC25A protein]		 CTD PMID:17129604 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO bosutinib promotes the reaction [CTNNB1 protein binds to CDH1 protein]; CTNNB1 protein promotes the reaction [bosutinib results in increased stability of CDH1 protein] CTD PMID:16489032 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity
decreases expression		 ISO bosutinib results in decreased activity of CDK2 protein
bosutinib results in decreased expression of CDK2 protein		 CTD PMID:17129604 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO bosutinib results in increased expression of CDKN1A protein CTD PMID:17129604 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions		 ISO bosutinib results in increased expression of CDKN1B protein
Imatinib Mesylate promotes the reaction [bosutinib results in increased expression of CDKN1B protein]		 CTD PMID:17129604 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Csk C-terminal Src kinase decreases activity EXP bosutinib results in decreased activity of CSK protein CTD PMID:17114238 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303 		JBrowse link
G Ctnnb1 catenin beta 1 affects localization
decreases phosphorylation
multiple interactions		 ISO bosutinib affects the localization of CTNNB1 protein
bosutinib results in decreased phosphorylation of CTNNB1 protein
bosutinib inhibits the reaction [CTNNB1 protein binds to TCF4 protein]; bosutinib inhibits the reaction [SRC protein results in increased phosphorylation of CTNNB1 protein]; bosutinib promotes the reaction [CTNNB1 protein binds to CDH1 protein]; CTNNB1 protein promotes the reaction [bosutinib results in increased stability of CDH1 protein]		 CTD PMID:16489032 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Egfr epidermal growth factor receptor decreases activity ISO bosutinib results in decreased activity of EGFR protein CTD PMID:18385429 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases phosphorylation EXP bosutinib results in decreased phosphorylation of ERBB2 protein CTD PMID:18385429 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728 		JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases activity EXP bosutinib results in decreased activity of FGR protein CTD PMID:17114238 NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO bosutinib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase decreases activity EXP bosutinib results in decreased activity of LYN protein CTD PMID:17114238 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648 		JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO bosutinib inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:74,578,600...74,706,068
Ensembl chr  X:74,577,131...74,706,214 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation
multiple interactions		 ISO bosutinib results in decreased phosphorylation of SRC protein
bosutinib inhibits the reaction [SRC protein results in increased phosphorylation of CTNNB1 protein]		 CTD PMID:16489032 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Tcf4 transcription factor 4 multiple interactions ISO bosutinib inhibits the reaction [CTNNB1 protein binds to TCF4 protein] CTD PMID:16489032 NCBI chr18:65,285,320...65,507,983
Ensembl chr18:65,155,685...65,507,977 		JBrowse link
clozapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Clozapine results in decreased activity of ABCB11 protein CTD PMID:22646477 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity		 EXP
ISO		 Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein]
Clozapine results in decreased activity of ABCB1 protein		 CTD PMID:9111066, PMID:16810505 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B multiple interactions EXP Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter] CTD PMID:9111066 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO Clozapine results in increased expression of ABCG1 mRNA CTD PMID:17346280 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] CTD PMID:18834354 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Ablim2 actin binding LIM protein family, member 2 increases expression ISO Clozapine results in increased expression of ABLIM2 mRNA CTD PMID:17346280 NCBI chr14:80,044,217...80,169,491
Ensembl chr14:80,045,078...80,169,472 		JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression ISO Clozapine results in increased expression of ACAT2 mRNA CTD PMID:17052361 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA CTD PMID:23226405 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050 		JBrowse link
G Adam1a ADAM metallopeptidase domain 1a decreases expression EXP Clozapine results in decreased expression of ADAM1A mRNA CTD PMID:16715494 NCBI chr12:40,533,731...40,536,632
Ensembl chr12:40,533,632...40,536,620 		JBrowse link
G Adcy5 adenylate cyclase 5 affects response to substance
multiple interactions		 ISO ADCY5 protein affects the susceptibility to Clozapine
SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine]		 CTD PMID:12223546 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression
increases expression
multiple interactions		 ISO
EXP		 Clozapine results in decreased expression of ADIPOQ protein
Clozapine results in increased expression of ADIPOQ protein
Clozapine results in increased expression of ADIPOQ mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]		 CTD PMID:17933447, PMID:18162013, PMID:20564506 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Clozapine results in decreased expression of ADORA2A mRNA CTD PMID:17266109 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873 		JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions EXP Clozapine binds to and results in decreased activity of ADRA1A protein CTD PMID:16545797 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451 		JBrowse link
G Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 decreases expression ISO Clozapine results in decreased expression of AGPAT1 mRNA CTD PMID:14647396 NCBI chr20:4,369,399...4,378,272
Ensembl chr20:4,369,178...4,378,269 		JBrowse link
G Agt angiotensinogen multiple interactions ISO Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]] CTD PMID:11549694 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
decreases expression
increases phosphorylation		 ISO
EXP		 Clozapine results in increased expression of AKT1 mRNA; Clozapine results in increased expression of AKT1 protein
Clozapine results in decreased expression of AKT1 mRNA
Clozapine results in increased phosphorylation of AKT1 protein		 CTD PMID:15860345, PMID:19440698 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 increases expression EXP Clozapine results in increased expression of AKT2 mRNA CTD PMID:15860345 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162 		JBrowse link
G Alb albumin multiple interactions
affects binding		 EXP
ISO		 Clozapine results in decreased expression of and results in decreased reduction of ALB protein
Clozapine binds to ALB protein
[[[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine] which affects the activity of ALB protein; [[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine; [stearic acid binds to ALB protein] which affects the susceptibility to Clozapine; stearic acid inhibits the reaction [Clozapine binds to ALB protein]		 CTD PMID:31400341 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO Clozapine results in increased expression of ALDH1A1 mRNA CTD PMID:17266109 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Clozapine results in increased expression of ALDOA mRNA CTD PMID:15860345 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression
increases expression		 ISO
EXP		 Clozapine results in decreased expression of ALDOC mRNA
Clozapine results in increased expression of ALDOC mRNA		 CTD PMID:15860345, PMID:16465460 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126 		JBrowse link
G Alpp alkaline phosphatase, placental multiple interactions ISO Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA] CTD PMID:16036225 NCBI chr 9:94,189,961...94,193,054
Ensembl chr 9:94,190,067...94,192,813 		JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Clozapine results in decreased expression of AP1S1 mRNA CTD PMID:17175557 NCBI chr12:22,665,128...22,676,079
Ensembl chr12:22,665,112...22,676,075 		JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 increases expression EXP Clozapine results in increased expression of AP2B1 mRNA CTD PMID:15860345 NCBI chr10:70,516,462...70,621,973
Ensembl chr10:70,520,206...70,621,977 		JBrowse link
G Apoa5 apolipoprotein A5 affects response to substance EXP APOA5 gene polymorphism affects the susceptibility to Clozapine CTD PMID:17726453 NCBI chr 8:50,559,079...50,561,720
Ensembl chr 8:50,559,126...50,561,736 		JBrowse link
G Apod apolipoprotein D increases expression ISO Clozapine results in increased expression of APOD mRNA; Clozapine results in increased expression of APOD protein CTD PMID:11158250, PMID:14647396, PMID:17266109 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein decreases expression EXP Clozapine results in decreased expression of ARC mRNA CTD PMID:18208916 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541 		JBrowse link
G Arhgef9 Cdc42 guanine nucleotide exchange factor 9 decreases expression ISO Clozapine results in decreased expression of ARHGEF9 mRNA CTD PMID:17266109 NCBI chr  X:64,249,576...64,428,444
Ensembl chr  X:64,248,278...64,428,592 		JBrowse link
G Arpc4 actin related protein 2/3 complex, subunit 4 affects expression ISO Clozapine affects the expression of ARPC4 mRNA CTD PMID:14647396 NCBI chr 4:145,330,457...145,340,985
Ensembl chr 4:145,330,457...145,340,984 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Clozapine results in increased expression of ASAH1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Clozapine results in increased expression of ASNS mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression EXP Clozapine results in decreased expression of ATP5F1B protein CTD PMID:19441803 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749 		JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 decreases expression EXP Clozapine results in decreased expression of ATP6V1B2 protein CTD PMID:19441803 NCBI chr16:22,326,537...22,350,143
Ensembl chr16:22,326,529...22,350,155 		JBrowse link
G Axin2 axin 2 decreases expression EXP Clozapine results in decreased expression of AXIN2 mRNA CTD PMID:16715494 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
decreases expression		 ISO
EXP		 Clozapine results in increased expression of BAX mRNA; Clozapine results in increased expression of BAX protein
CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]
Clozapine results in decreased expression of BAX protein		 CTD PMID:16160616, PMID:17069804 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Clozapine results in increased expression of BCL2 mRNA; Clozapine results in increased expression of BCL2 protein CTD PMID:15126120 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
increases expression		 EXP Clozapine results in decreased expression of BDNF mRNA
Clozapine results in increased expression of BDNF mRNA; Clozapine results in increased expression of BDNF protein		 CTD PMID:11488957, PMID:12478621, PMID:17442489 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Bet1l Bet1 golgi vesicular membrane trafficking protein-like decreases expression EXP Clozapine results in decreased expression of BET1L mRNA CTD PMID:15860345 NCBI chr 1:213,602,836...213,606,507
Ensembl chr 1:213,602,850...213,605,643 		JBrowse link
G Bik BCL2-interacting killer multiple interactions
increases expression		 ISO CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA] CTD PMID:16160616 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447 		JBrowse link
G Bptf bromodomain PHD finger transcription factor decreases expression ISO Clozapine results in decreased expression of BPTF mRNA CTD PMID:14647396 NCBI chr10:95,248,573...95,350,162
Ensembl chr10:95,250,294...95,349,789 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A decreases expression ISO
EXP		 Clozapine results in decreased expression of CACNA1A mRNA CTD PMID:14647396, PMID:16715494 NCBI chr19:25,453,236...25,749,550
Ensembl chr19:25,526,751...25,749,550 		JBrowse link
G Calm2 calmodulin 2 increases expression EXP Clozapine results in increased expression of CALM2 mRNA CTD PMID:19289156 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases expression
increases expression		 ISO
EXP		 Clozapine results in decreased expression of CAMK2A mRNA
Clozapine results in increased expression of CAMK2A mRNA
Clozapine results in decreased expression of CAMK2A protein		 CTD PMID:15860345, PMID:17266109, PMID:19289156 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression EXP Clozapine results in decreased expression of CAMK2B mRNA CTD PMID:15860345 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta decreases expression EXP Clozapine results in decreased expression of CAMK2D mRNA CTD PMID:15860345 NCBI chr 2:230,900,907...231,132,207
Ensembl chr 2:230,901,126...231,132,039 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV increases expression
decreases expression		 EXP Clozapine results in increased expression of CAMK4 mRNA
Clozapine results in decreased expression of CAMK4 protein		 CTD PMID:15860345, PMID:19289156 NCBI chr18:25,746,878...25,975,962
Ensembl chr18:25,749,098...25,965,957 		JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 decreases expression EXP Clozapine results in decreased expression of CAMKK1 protein CTD PMID:19289156 NCBI chr10:59,585,023...59,608,180
Ensembl chr10:59,585,072...59,608,165 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 decreases expression EXP Clozapine results in decreased expression of CAMKK2 protein CTD PMID:19289156 NCBI chr12:39,253,409...39,302,601
Ensembl chr12:39,253,409...39,302,601 		JBrowse link
G Cartpt CART prepropeptide decreases expression EXP Clozapine results in decreased expression of CARTPT mRNA CTD PMID:14696011 NCBI chr 2:30,125,249...30,127,408
Ensembl chr 2:30,125,249...30,127,269 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO
EXP		 Clozapine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP3 protein]		 CTD PMID:22700542, PMID:24709159 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO Clozapine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP7 protein]		 CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Cat catalase multiple interactions ISO Clozapine inhibits the reaction [Corticosterone results in increased activity of CAT protein]; Clozapine inhibits the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]] CTD PMID:14730115 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cck cholecystokinin multiple interactions
increases expression		 EXP Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein]
Clozapine results in increased expression of CCK mRNA		 CTD PMID:10974607, PMID:16567023 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392 		JBrowse link
G Cckbr cholecystokinin B receptor increases expression ISO Clozapine results in increased expression of CCKBR mRNA CTD PMID:17266109 NCBI chr 1:170,262,218...170,272,298
Ensembl chr 1:170,262,156...170,272,298 		JBrowse link
G Ccl1 C-C motif chemokine ligand 1 decreases expression ISO Clozapine results in decreased expression of CCL1 mRNA CTD PMID:17346280 NCBI chr10:69,534,976...69,537,836
Ensembl chr10:69,534,933...69,537,882 		JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Clozapine results in decreased expression of CCND1 mRNA CTD PMID:15860345 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccnd3 cyclin D3 increases expression EXP Clozapine results in increased expression of CCND3 mRNA CTD PMID:15860345 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943 		JBrowse link
G Ccnl1 cyclin L1 increases expression EXP Clozapine results in increased expression of CCNL1 mRNA CTD PMID:15860345 NCBI chr 2:157,747,295...157,759,838
Ensembl chr 2:157,747,542...157,759,838 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP Clozapine results in increased expression of CDK4 mRNA CTD PMID:15860345 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 increases expression EXP Clozapine results in increased expression of CDK5 mRNA CTD PMID:15860345 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression ISO Clozapine results in increased expression of CDK5R1 mRNA CTD PMID:17266109 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]
Clozapine results in increased expression of CEBPA mRNA; Clozapine results in increased expression of CEBPA protein		 CTD PMID:20564506 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164 		JBrowse link
G Chga chromogranin A decreases expression
increases expression		 EXP Clozapine results in decreased expression of CHGA mRNA
Clozapine results in increased expression of CHGA mRNA		 CTD PMID:12437575 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568 		JBrowse link
G Chl1 cell adhesion molecule L1-like decreases expression ISO Clozapine results in decreased expression of CHL1 mRNA CTD PMID:14647396 NCBI chr 4:70,269,414...70,331,313
Ensembl chr 4:70,252,366...70,330,803 		JBrowse link
G Chn1 chimerin 1 decreases expression ISO Clozapine results in decreased expression of CHN1 mRNA CTD PMID:14647396 NCBI chr 3:60,512,360...60,668,413
Ensembl chr 3:60,513,077...60,611,924 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 affects binding
increases expression
multiple interactions		 ISO
EXP		 Clozapine analog binds to CHRM1 protein; Clozapine binds to CHRM1 protein
Clozapine results in increased expression of CHRM1 protein
Clozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein]		 CTD PMID:11997696, PMID:16983399, PMID:18806925 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205 		JBrowse link
G Clock clock circadian regulator affects response to substance ISO CLOCK gene SNP affects the susceptibility to Clozapine CTD PMID:15331141 NCBI chr14:34,418,226...34,502,218
Ensembl chr14:34,446,616...34,502,218 		JBrowse link
G Clta clathrin, light chain A decreases expression EXP Clozapine results in decreased expression of CLTA mRNA CTD PMID:15860345 NCBI chr 5:59,490,689...59,509,139
Ensembl chr 5:59,491,096...59,509,138 		JBrowse link
G Cltb clathrin, light chain B decreases expression EXP Clozapine results in decreased expression of CLTB mRNA CTD PMID:15860345 NCBI chr17:10,537,348...10,554,999
Ensembl chr17:10,537,365...10,554,989 		JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression
increases expression		 ISO Clozapine results in decreased expression of CNP mRNA
Clozapine results in increased expression of CNP mRNA		 CTD PMID:17266109 NCBI chr10:88,490,798...88,497,357
Ensembl chr10:88,490,798...88,497,356 		JBrowse link
G Coil coilin increases expression EXP Clozapine results in increased expression of COIL mRNA CTD PMID:16715494 NCBI chr10:76,320,676...76,336,169
Ensembl chr10:76,320,041...76,341,418 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions
affects response to substance
increases response to substance		 EXP
ISO		 [tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]
COMT protein affects the susceptibility to Clozapine
COMT gene polymorphism results in increased susceptibility to Clozapine		 CTD PMID:15190105, PMID:17123785 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622 		JBrowse link
G Cplx2 complexin 2 decreases expression ISO Clozapine results in decreased expression of CPLX2 mRNA CTD PMID:17266109 NCBI chr17:10,756,871...10,828,811
Ensembl chr17:10,756,285...10,818,835 		JBrowse link
G Cpn1 carboxypeptidase N subunit 1 increases expression EXP Clozapine results in increased expression of CPN1 mRNA CTD PMID:16715494 NCBI chr 1:263,733,887...263,762,758
Ensembl chr 1:263,733,519...263,762,785 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions EXP [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA CTD PMID:23226405 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases phosphorylation		 ISO Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein]
Clozapine results in decreased phosphorylation of CREB1 protein		 CTD PMID:12871586 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Clozapine results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863 		JBrowse link
G Crhbp corticotropin releasing hormone binding protein decreases expression EXP Clozapine results in decreased expression of CRHBP mRNA CTD PMID:16715494 NCBI chr 2:25,141,471...25,153,334
Ensembl chr 2:25,141,471...25,153,334 		JBrowse link
G Crp C-reactive protein increases expression ISO Clozapine results in increased expression of CRP protein CTD PMID:17685758 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA] CTD PMID:16160616 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 decreases expression EXP Clozapine results in decreased expression of CSNK2A1 mRNA CTD PMID:16715494 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862 		JBrowse link
G Cst3 cystatin C increases expression ISO Clozapine results in increased expression of CST3 mRNA CTD PMID:14647396 NCBI chr 3:143,219,671...143,223,544
Ensembl chr 3:143,219,686...143,223,615 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions		 EXP Clozapine results in increased expression of CTNNB1 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]		 CTD PMID:16144542 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Ctrl chymotrypsin-like increases expression EXP Clozapine results in increased expression of CTRL mRNA CTD PMID:16715494 NCBI chr19:37,905,864...37,907,714
Ensembl chr19:37,905,864...37,907,714 		JBrowse link
G Ctsk cathepsin K increases expression EXP Clozapine results in increased expression of CTSK mRNA CTD PMID:16715494 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Clozapine results in decreased expression of CXCL1 mRNA CTD PMID:17346280 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Clozapine results in decreased expression of CXCL1 mRNA CTD PMID:17346280 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595 		JBrowse link
G Cyb5b cytochrome b5 type B increases expression EXP Clozapine results in increased expression of CYB5B mRNA CTD PMID:19441803 NCBI chr19:39,357,814...39,391,680
Ensembl chr19:39,357,791...39,393,189 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases metabolic processing		 EXP
ISO		 Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CYP1A1 protein results in increased metabolism of Clozapine		 CTD PMID:18493746, PMID:18809730 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases response to substance
multiple interactions
increases metabolic processing
increases expression
affects metabolic processing
affects response to substance
decreases metabolic processing		 ISO
EXP		 CYP1A2 gene SNP results in decreased susceptibility to Clozapine
Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CYP1A2 protein results in increased metabolism of Clozapine
Clozapine results in increased expression of CYP1A2 mRNA
CYP1A2 gene polymorphism affects the metabolism of Clozapine; CYP1A2 protein affects the metabolism of Clozapine; CYP1A2 protein polymorphism affects the metabolism of Clozapine
[Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Smoke affects the reaction [CYP1A2 gene polymorphism affects the metabolism of Clozapine]; Smoke promotes the reaction [CYP1A2 protein results in increased metabolism of Clozapine]
CYP1A2 gene SNP affects the susceptibility to Clozapine; CYP1A2 protein affects the susceptibility to Clozapine
CYP1A2 gene SNP results in increased metabolism of Clozapine; CYP1A2 protein results in increased metabolism of Clozapine
CYP1A2 gene SNP results in decreased metabolism of Clozapine		 CTD PMID:11151749, PMID:11763009, PMID:12919186, PMID:12969762, PMID:15206669, PMID:15286053, PMID:15883149, PMID:15949157, PMID:16044115, PMID:18493746, PMID:18809730, PMID:23397584, PMID:27320963 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing ISO CYP1B1 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
increases metabolic processing		 ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine
CYP2C19 protein results in increased metabolism of Clozapine		 CTD PMID:18809730, PMID:23397584, PMID:27320963 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of Clozapine CTD PMID:18809730, PMID:27320963 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
increases metabolic processing
multiple interactions		 ISO CYP2D6 protein affects the metabolism of Clozapine
CYP2D6 protein results in increased metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine		 CTD PMID:15286053, PMID:18809730, PMID:23397584, PMID:27320963 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases metabolic processing ISO CYP2J2 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Dab1 DAB adaptor protein 1 increases expression EXP Clozapine results in increased expression of DAB1 mRNA CTD PMID:19359144 NCBI chr 5:123,154,360...124,279,170
Ensembl chr 5:123,905,166...124,280,115 		JBrowse link
G Dcaf6 DDB1 and CUL4 associated factor 6 decreases expression ISO Clozapine results in decreased expression of DCAF6 mRNA CTD PMID:14647396 NCBI chr13:83,578,730...83,680,330
Ensembl chr13:83,579,036...83,680,207 		JBrowse link
G Dclk1 doublecortin-like kinase 1 increases expression ISO
EXP		 Clozapine results in increased expression of DCLK1 mRNA CTD PMID:15860345, PMID:18797397 NCBI chr 2:144,646,255...144,939,389
Ensembl chr 2:144,646,308...144,936,927 		JBrowse link
G Ddc dopa decarboxylase multiple interactions
increases expression		 ISO Clozapine results in increased expression of and results in increased activity of DDC protein
Clozapine results in increased expression of DDC mRNA		 CTD PMID:16415089 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774 		JBrowse link
G Dennd10 DENN domain containing 10 increases expression EXP Clozapine results in increased expression of DENND10 mRNA CTD PMID:16715494 NCBI chr 1:282,188,080...282,211,588
Ensembl chr 1:282,188,110...282,210,580 		JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Clozapine results in increased expression of DEPP1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562 		JBrowse link
G Dgka diacylglycerol kinase, alpha decreases expression EXP Clozapine results in decreased expression of DGKA mRNA CTD PMID:15860345 NCBI chr 7:3,143,826...3,170,764
Ensembl chr 7:3,143,827...3,170,146 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression ISO Clozapine results in increased expression of DHCR7 mRNA CTD PMID:17052361 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904 		JBrowse link
G Disc1 DISC1 scaffold protein decreases response to substance
affects response to substance		 ISO DISC1 gene mutant form results in decreased susceptibility to Clozapine
DISC1 protein affects the susceptibility to Clozapine		 CTD PMID:20531374 NCBI chr19:57,818,838...58,069,992
Ensembl chr19:57,820,260...58,066,152 		JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase decreases expression EXP Clozapine results in decreased expression of DLAT mRNA CTD PMID:15860345 NCBI chr 8:55,062,549...55,087,832
Ensembl chr 8:55,062,551...55,087,832 		JBrowse link
G Dpf1 double PHD fingers 1 affects expression ISO Clozapine affects the expression of DPF1 mRNA CTD PMID:14647396 NCBI chr 1:87,248,448...87,258,070
Ensembl chr 1:87,248,489...87,258,070 		JBrowse link
G Drd1 dopamine receptor D1 affects binding
decreases expression
affects response to substance		 ISO
EXP		 Clozapine binds to DRD1 protein
Clozapine results in decreased expression of DRD1 mRNA
Clozapine analog binds to DRD1 protein
DRD1 gene polymorphism affects the susceptibility to Clozapine; DRD1 protein affects the susceptibility to Clozapine		 CTD PMID:1352677, PMID:9723970, PMID:11997696, PMID:17092969, PMID:17266109 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects binding
affects response to substance
decreases expression
increases response to substance		 ISO
EXP		 [Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein
Clozapine binds to DRD2 protein
DRD2 protein affects the susceptibility to Clozapine
Clozapine results in decreased expression of DRD2 mRNA
Clozapine analog binds to DRD2 protein; Clozapine binds to DRD2 protein
[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]; Clozapine binds to and results in decreased activity of DRD2 protein; Clozapine promotes the reaction [Dopamine binds to DRD2 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]
[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA
Clozapine binds to DRD2 protein alternative form
DRD2 gene SNP results in increased susceptibility to Clozapine
DRD2 gene affects the susceptibility to Clozapine; DRD2 gene polymorphism affects the susceptibility to Clozapine		 CTD PMID:1352677, PMID:9723970, PMID:11997696, PMID:12476322, PMID:15286066, PMID:15716360, PMID:15781964, PMID:15830237, PMID:16033416, PMID:16144542, PMID:16278074, PMID:17266109, PMID:20375926 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Drd3 dopamine receptor D3 affects response to substance
multiple interactions
decreases response to substance		 ISO DRD3 protein affects the susceptibility to Clozapine
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
DRD3 gene polymorphism results in decreased susceptibility to Clozapine		 CTD PMID:15579174, PMID:20029384 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327 		JBrowse link
G Drd4 dopamine receptor D4 affects binding
multiple interactions
affects response to substance		 ISO
EXP		 Clozapine binds to DRD4 protein
Clozapine inhibits the reaction [Dopamine results in increased activity of DRD4 protein]
Clozapine analog binds to DRD4 protein
DRD4 gene polymorphism affects the susceptibility to Clozapine		 CTD PMID:11997696, PMID:16223700, PMID:31323226 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483 		JBrowse link
G Drp2 dystrophin related protein 2 increases expression EXP Clozapine results in increased expression of DRP2 mRNA alternative form CTD PMID:16715494 NCBI chr  X:105,239,623...105,290,233
Ensembl chr  X:105,239,620...105,289,808 		JBrowse link
G Dtnbp1 dystrobrevin binding protein 1 increases response to substance
affects response to substance		 ISO DTNBP1 gene polymorphism results in increased susceptibility to Clozapine
DTNBP1 protein affects the susceptibility to Clozapine		 CTD PMID:19369910 NCBI chr17:20,090,136...20,182,332
Ensembl chr17:20,090,246...20,182,206 		JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression EXP Clozapine results in decreased expression of DUSP1 mRNA CTD PMID:15860345 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418 		JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression EXP Clozapine results in decreased expression of DUSP6 mRNA CTD PMID:15860345 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392 		JBrowse link
G Dvl3 dishevelled segment polarity protein 3 increases expression
multiple interactions		 EXP Clozapine results in increased expression of DVL3 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]		 CTD PMID:16144542 NCBI chr11:84,051,177...84,068,479
Ensembl chr11:84,051,078...84,068,302 		JBrowse link
G Egr1 early growth response 1 decreases expression EXP Clozapine results in decreased expression of EGR1 mRNA; Clozapine results in decreased expression of EGR1 protein CTD PMID:17028028, PMID:18208916 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Egr2 early growth response 2 affects expression
decreases expression		 ISO
EXP		 Clozapine affects the expression of EGR2 mRNA
Clozapine results in decreased expression of EGR2 protein		 CTD PMID:17028028, PMID:19401217 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025 		JBrowse link
G Egr3 early growth response 3 affects response to substance ISO EGR3 protein affects the susceptibility to Clozapine CTD PMID:17637609 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722 		JBrowse link
G Elk1 ETS transcription factor ELK1 decreases phosphorylation ISO Clozapine results in decreased phosphorylation of ELK1 protein CTD PMID:12871586 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822 		JBrowse link
G Eno1 enolase 1 increases expression EXP Clozapine results in increased expression of ENO1 mRNA CTD PMID:15860345 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609 		JBrowse link
G Epha7 Eph receptor A7 increases expression ISO Clozapine results in increased expression of EPHA7 mRNA CTD PMID:17266109 NCBI chr 5:43,602,744...43,761,198
Ensembl chr 5:43,603,043...43,757,549 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects phosphorylation EXP Clozapine affects the phosphorylation of ERBB2 protein CTD PMID:26961615 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions EXP Clozapine results in increased expression of and results in increased phosphorylation of ERBB4 protein CTD PMID:26961615 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Clozapine results in increased expression of FABP1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA CTD PMID:20564506 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [Clozapine analog co-treated with Hydrogen Peroxide] results in increased expression of FASLG mRNA; [Clozapine co-treated with Hydrogen Peroxide co-treated with Tretinoin] results in increased expression of FASLG mRNA CTD PMID:16510162 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fasn fatty acid synthase increases expression ISO Clozapine results in increased expression of FASN mRNA CTD PMID:16027736, PMID:17052361 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Fdps farnesyl diphosphate synthase increases expression ISO Clozapine results in increased expression of FDPS mRNA CTD PMID:17052361 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression EXP Clozapine results in increased expression of FGF2 mRNA CTD PMID:11264663 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases metabolic processing ISO FMO1 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of Clozapine CTD PMID:18809730, PMID:27320963 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases expression		 EXP Clozapine affects the reaction [Haloperidol results in increased expression of FOS protein]; Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA]
Clozapine analog results in increased expression of FOS protein; Clozapine results in increased expression of FOS mRNA; Clozapine results in increased expression of FOS protein
Clozapine results in decreased expression of FOS protein		 CTD PMID:10435392, PMID:11166331, PMID:11440804, PMID:11997696, PMID:12093589, PMID:12243769, PMID:12464447, PMID:17028028, PMID:18208916, PMID:18521575, PMID:19695244 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
decreases expression		 ISO
EXP		 Clozapine results in increased expression of FOSB protein alternative form
Clozapine results in increased expression of FOSB mRNA; Clozapine results in increased expression of FOSB protein
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
Clozapine results in decreased expression of FOSB mRNA		 CTD PMID:11259127, PMID:12093589, PMID:12243769, PMID:15579174, PMID:19695244 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression EXP Clozapine results in increased expression of FOSL1 mRNA CTD PMID:18208916 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression EXP Clozapine results in increased expression of FOSL2 mRNA CTD PMID:12093589, PMID:12243769 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995 		JBrowse link
G Foxp2 forkhead box P2 increases expression ISO Clozapine results in increased expression of FOXP2 mRNA CTD PMID:17266109 NCBI chr 4:41,364,441...41,944,685
Ensembl chr 4:41,364,441...41,942,023 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 decreases expression ISO Clozapine results in decreased expression of GABBR1 mRNA CTD PMID:17266109 NCBI chr20:1,955,344...1,984,907
Ensembl chr20:1,955,359...1,984,863 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases expression ISO Clozapine results in increased expression of GABRA1 mRNA CTD PMID:17266109 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases expression EXP Clozapine results in increased expression of GABRB3 mRNA CTD PMID:18923069 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364 		JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression
decreases methylation
multiple interactions		 ISO
EXP		 Clozapine results in increased expression of GAD1 mRNA
Clozapine results in decreased methylation of GAD1 promoter
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]; Valproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter]		 CTD PMID:12887421, PMID:15061247, PMID:17942719, PMID:18757738, PMID:18923069 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157 		JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression ISO
EXP		 Clozapine results in increased expression of GAD2 mRNA CTD PMID:17266109, PMID:18923069 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression EXP Clozapine results in increased expression of GAPDH mRNA CTD PMID:15860345 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Clozapine results in increased expression of GDPD3 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression		 EXP Clozapine results in decreased expression of GFAP protein
Clozapine results in increased expression of GFAP mRNA		 CTD PMID:18585900, PMID:19441803 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Gimap5 GTPase, IMAP family member 5 decreases expression EXP Clozapine results in decreased expression of GIMAP5 mRNA CTD PMID:16715494 NCBI chr 4:78,377,228...78,386,683
Ensembl chr 4:78,378,144...78,385,577 		JBrowse link
G Gip gastric inhibitory polypeptide increases expression EXP Clozapine results in increased expression of GIP mRNA; Clozapine results in increased expression of GIP protein CTD PMID:16402076 NCBI chr10:83,835,080...83,848,399
Ensembl chr10:83,840,303...83,848,396 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP Clozapine results in increased expression of GJA1 protein CTD PMID:18585900 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089 		JBrowse link
G Gna12 G protein subunit alpha 12 decreases expression EXP Clozapine results in decreased expression of GNA12 mRNA CTD PMID:15860345 NCBI chr12:15,890,202...15,971,212
Ensembl chr12:15,890,170...15,971,212 		JBrowse link
G Gnai1 G protein subunit alpha i1 decreases expression EXP Clozapine results in decreased expression of GNAI1 mRNA CTD PMID:15860345 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883 		JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP Clozapine results in decreased expression of GNAI2 mRNA CTD PMID:15860345 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307 		JBrowse link
G Gnai3 G protein subunit alpha i3 decreases expression EXP Clozapine results in decreased expression of GNAI3 mRNA CTD PMID:15860345 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749 		JBrowse link
G Gnas GNAS complex locus decreases expression EXP Clozapine results in decreased expression of GNAS mRNA CTD PMID:15860345 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483 		JBrowse link
G Gnb3 G protein subunit beta 3 decreases response to substance
increases expression
affects response to substance
increases response to substance		 ISO
EXP		 GNB3 gene polymorphism results in decreased susceptibility to Clozapine
Clozapine results in increased expression of GNB3 protein
GNB3 protein affects the susceptibility to Clozapine
GNB3 gene polymorphism results in increased susceptibility to Clozapine		 CTD PMID:16139171, PMID:16141801, PMID:18855531 NCBI chr 4:157,352,558...157,359,237
Ensembl chr 4:157,352,372...157,358,262 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression EXP Clozapine results in increased expression of GOT2 mRNA CTD PMID:15860345 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Clozapine results in increased expression of GPX1 mRNA CTD PMID:14647396 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 increases expression EXP Clozapine results in increased expression of GRIK2 mRNA CTD PMID:18923069 NCBI chr20:53,791,428...54,517,691
Ensembl chr20:53,789,760...54,517,709 		JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 affects expression
decreases expression		 ISO
EXP		 Clozapine affects the expression of GRIK5 mRNA
Clozapine results in decreased expression of GRIK5 mRNA		 CTD PMID:14647396, PMID:18923069 NCBI chr 1:81,885,516...81,946,731
Ensembl chr 1:81,885,521...81,946,714 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression
increases expression		 ISO
EXP		 Clozapine results in decreased expression of GRIN1 mRNA
Clozapine results in increased expression of GRIN1 mRNA		 CTD PMID:12020038, PMID:12608697, PMID:17266109, PMID:18923069 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression EXP Clozapine results in decreased expression of GRIN2A mRNA CTD PMID:12608697, PMID:18923069 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression EXP Clozapine results in decreased expression of GRIN2B mRNA CTD PMID:18923069 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C decreases expression EXP Clozapine results in decreased expression of GRIN2C mRNA CTD PMID:18923069 NCBI chr10:103,798,290...103,816,923
Ensembl chr10:103,798,291...103,816,287 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 decreases expression EXP Clozapine results in decreased expression of GRK6 mRNA CTD PMID:16715494 NCBI chr17:9,705,917...9,721,921
Ensembl chr17:9,703,453...9,721,574 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases expression
multiple interactions		 EXP Clozapine results in increased expression of GSK3A protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]		 CTD PMID:16144542 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
increases expression
multiple interactions		 ISO
EXP		 Clozapine results in increased phosphorylation of GSK3B protein
Clozapine results in increased expression of GSK3B protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]		 CTD PMID:16144542, PMID:19359144, PMID:19440698 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity
increases glutathionylation		 ISO GSTA1 protein results in decreased activity of Clozapine
GSTA1 protein results in increased glutathionylation of Clozapine		 CTD PMID:20849150 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity
increases expression
increases glutathionylation		 ISO
EXP		 GSTM1 protein results in decreased activity of Clozapine
Clozapine results in increased expression of GSTM1 mRNA
GSTM1 protein results in increased glutathionylation of Clozapine		 CTD PMID:15860345, PMID:20849150 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Clozapine results in decreased expression of GSTM2 mRNA CTD PMID:15860345 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity
affects metabolic processing
increases glutathionylation
affects binding		 ISO Clozapine metabolite results in decreased activity of GSTP1 protein; GSTP1 protein results in decreased activity of Clozapine
GSTP1 protein affects the metabolism of Clozapine metabolite
GSTP1 protein results in increased glutathionylation of Clozapine
Clozapine metabolite binds to GSTP1 protein		 CTD PMID:20849150, PMID:21639118, PMID:24185126 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A increases expression ISO Clozapine results in increased expression of HIGD1A mRNA CTD PMID:14647396 NCBI chr 8:130,482,492...130,491,888
Ensembl chr 8:130,482,493...130,491,998 		JBrowse link
G Hist2h2aa2 histone cluster 2 H2A family member A2 increases expression ISO Clozapine results in increased expression of H2AC18 mRNA CTD PMID:14647396 NCBI chr 2:198,381,678...198,382,247
Ensembl chr 2:198,388,809...198,389,201
Ensembl chr 2:198,388,809...198,389,201 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
increases activity		 ISO [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides
Clozapine results in increased expression of HMGCR mRNA		 CTD PMID:16027736, PMID:17052361 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Clozapine results in increased expression of HMGCS1 mRNA CTD PMID:16027736, PMID:17052361 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Clozapine results in increased expression of HMOX1 mRNA CTD PMID:18227147 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Homer1 homer scaffold protein 1 increases expression
multiple interactions		 EXP Clozapine results in increased expression of HOMER1 mRNA
Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]		 CTD PMID:12464447, PMID:15860345 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678 		JBrowse link
G Hpcal1 hippocalcin-like 1 decreases expression EXP Clozapine results in decreased expression of HPCAL1 mRNA CTD PMID:12437575 NCBI chr 6:43,001,920...43,109,083
Ensembl chr 6:43,001,948...43,109,071 		JBrowse link
G Hpcal4 hippocalcin-like 4 affects expression EXP Clozapine affects the expression of HPCAL4 mRNA CTD PMID:12437575 NCBI chr 5:140,870,127...140,882,242
Ensembl chr 5:140,870,140...140,882,244 		JBrowse link
G Hpn hepsin increases expression ISO Clozapine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967 		JBrowse link
G Hrh1 histamine receptor H 1 affects binding ISO Clozapine binds to HRH1 protein CTD PMID:16983399 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
affects binding		 ISO
EXP		 Clozapine binds to and affects the activity of HTR1A protein
Clozapine binds to HTR1A protein		 CTD PMID:9723970, PMID:15482641 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896 		JBrowse link
G Htr1d 5-hydroxytryptamine receptor 1D decreases expression EXP Clozapine results in decreased expression of HTR1D mRNA CTD PMID:16715494 NCBI chr 5:154,780,958...154,801,505
Ensembl chr 5:154,800,226...154,801,350 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases response to substance
affects binding
multiple interactions
decreases expression
decreases activity
affects response to substance
increases expression		 ISO
EXP		 HTR2A gene SNP results in increased susceptibility to Clozapine
Clozapine analog binds to HTR2A protein; Clozapine binds to HTR2A protein
Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein]
Clozapine results in decreased expression of HTR2A mRNA; Clozapine results in decreased expression of HTR2A protein
Clozapine results in decreased activity of HTR2A protein
[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]; Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein]
HTR2A protein affects the susceptibility to Clozapine
Clozapine results in increased expression of HTR2A mRNA		 CTD PMID:7520908, PMID:9723970, PMID:11997696, PMID:14751426, PMID:15380371, PMID:15542763, PMID:16314884, PMID:16983399, PMID:17868938, PMID:18976543, PMID:20521326 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding
decreases expression
affects response to substance		 ISO
EXP		 Clozapine binds to HTR2C protein
Clozapine results in decreased expression of HTR2C mRNA
HTR2C gene polymorphism affects the susceptibility to Clozapine; HTR2C gene SNP affects the susceptibility to Clozapine; HTR2C promoter SNP affects the susceptibility to Clozapine; HTR2C protein affects the susceptibility to Clozapine		 CTD PMID:9723970, PMID:12668355, PMID:15635667, PMID:16983399, PMID:17868938, PMID:19142101, PMID:19142110 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions
affects response to substance		 ISO Clozapine binds to and results in decreased activity of HTR3A protein
HTR3A protein affects the susceptibility to Clozapine		 CTD PMID:19696922, PMID:20168265 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804 		JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 multiple interactions
affects binding		 ISO Clozapine binds to and results in decreased activity of HTR6 protein
Clozapine binds to HTR6 protein		 CTD PMID:11406289, PMID:16983399 NCBI chr 5:157,501,202...157,518,870
Ensembl chr 5:157,503,040...157,518,631 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 affects binding
multiple interactions		 ISO Clozapine binds to HTR7 protein
[Clozapine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Clozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]		 CTD PMID:14578406, PMID:20827463 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778 		JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression EXP Clozapine results in increased expression of ID2 mRNA CTD PMID:12437575 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915 		JBrowse link
G Ifng interferon gamma affects expression
decreases expression		 ISO Clozapine affects the expression of IFNG protein
Clozapine results in decreased expression of IFNG mRNA		 CTD PMID:17346280 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO Clozapine results in decreased expression of IGF1 protein CTD PMID:11769361 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Il10 interleukin 10 decreases expression EXP Clozapine results in decreased expression of IL10 protein CTD PMID:24709159 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases secretion ISO Clozapine results in increased secretion of IL2RA protein CTD PMID:8067274 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071 		JBrowse link
G Il5 interleukin 5 affects expression ISO Clozapine affects the expression of IL5 protein CTD PMID:17346280 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587 		JBrowse link
G Ilkap ILK associated serine/threonine phosphatase decreases expression EXP Clozapine results in decreased expression of ILKAP mRNA CTD PMID:15860345 NCBI chr 9:98,514,599...98,536,586
Ensembl chr 9:98,514,584...98,536,581 		JBrowse link
G Inha inhibin subunit alpha decreases expression EXP Clozapine results in decreased expression of INHA mRNA CTD PMID:16715494 NCBI chr 9:82,700,482...82,703,383
Ensembl chr 9:82,700,468...82,703,400 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Clozapine results in increased expression of INHBE mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169 		JBrowse link
G Ins2 insulin 2 affects secretion
increases expression		 ISO Clozapine affects the secretion of INS protein
Clozapine results in increased expression of INS protein		 CTD PMID:11769361, PMID:16601995 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP [[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein] CTD PMID:18976543 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
increases expression		 EXP Clozapine results in decreased expression of JUN mRNA
Clozapine results in increased expression of JUN mRNA		 CTD PMID:12093589, PMID:15860345, PMID:18208916 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Clozapine results in increased expression of JUNB mRNA CTD PMID:12093589, PMID:19695244 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Clozapine results in decreased expression of JUND mRNA CTD PMID:12093589 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707 		JBrowse link
G Kcna1 potassium voltage-gated channel subfamily A member 1 increases expression ISO Clozapine results in increased expression of KCNA1 mRNA CTD PMID:18797397 NCBI chr 4:159,190,781...159,192,526
Ensembl chr 4:159,190,804...159,192,526 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Clozapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 decreases expression
increases expression		 ISO Clozapine results in decreased expression of KCNIP3 mRNA
Clozapine results in increased expression of KCNIP3 mRNA		 CTD PMID:17266109, PMID:18797397 NCBI chr 3:120,023,062...120,087,650
Ensembl chr 3:120,023,917...120,087,136 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 decreases expression ISO Clozapine results in decreased expression of KCNK2 mRNA CTD PMID:15542763 NCBI chr13:107,690,111...107,886,476
Ensembl chr13:107,690,087...107,886,476 		JBrowse link
G Kmt2a lysine methyltransferase 2A increases expression
decreases expression
multiple interactions		 ISO Clozapine results in increased expression of KMT2A mRNA
Clozapine results in decreased expression of KMT2A mRNA
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]		 CTD PMID:14647396, PMID:17942719 NCBI chr 8:49,110,407...49,185,872
Ensembl chr 8:49,114,990...49,158,971 		JBrowse link
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 increases expression ISO Clozapine results in increased expression of LAMTOR3 mRNA CTD PMID:14647396 NCBI chr 2:243,160,821...243,173,057
Ensembl chr 2:243,160,917...243,173,048 		JBrowse link
G Ldhb lactate dehydrogenase B increases expression EXP Clozapine results in increased expression of LDHB mRNA CTD PMID:15860345 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012 		JBrowse link
G Ldlr low density lipoprotein receptor increases expression
multiple interactions		 ISO Clozapine results in increased expression of LDLR mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]		 CTD PMID:17052361, PMID:20564506 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Lep leptin affects response to substance
increases expression		 ISO
EXP		 LEP protein affects the susceptibility to Clozapine
Clozapine results in increased expression of LEP protein		 CTD PMID:16402076, PMID:17502770 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G LOC103690091 proSAAS affects expression ISO Clozapine affects the expression of PCSK1N mRNA CTD PMID:14647396 NCBI chr  X:15,324,261...15,328,617 JBrowse link
G Lpl lipoprotein lipase decreases expression
increases expression		 ISO Clozapine results in decreased expression of LPL mRNA; Clozapine results in decreased expression of LPL protein
Clozapine results in increased expression of LPL mRNA		 CTD PMID:17266109, PMID:19682446 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496 		JBrowse link
G Lss lanosterol synthase increases expression ISO Clozapine results in increased expression of LSS mRNA CTD PMID:15342952, PMID:17175557 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497 		JBrowse link
G Mal mal, T-cell differentiation protein decreases expression ISO Clozapine results in decreased expression of MAL mRNA CTD PMID:17266109, PMID:18797397 NCBI chr 3:120,209,647...120,233,655
Ensembl chr 3:120,209,647...120,233,655 		JBrowse link
G Maob monoamine oxidase B increases expression ISO Clozapine results in increased expression of MAOB mRNA CTD PMID:17266109 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534 		JBrowse link
G Map1a microtubule-associated protein 1A increases expression EXP Clozapine results in increased expression of MAP1A mRNA CTD PMID:15860345 NCBI chr 3:113,251,918...113,272,193
Ensembl chr 3:113,251,778...113,272,186 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases expression EXP Clozapine results in decreased expression of MAP2K1 mRNA CTD PMID:15860345 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases expression
decreases expression		 ISO
EXP		 Clozapine results in increased expression of MAP2K2 mRNA
Clozapine results in decreased expression of MAP2K2 mRNA		 CTD PMID:14647396, PMID:15860345 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489 		JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 decreases expression EXP Clozapine results in decreased expression of MAP2K5 mRNA CTD PMID:15860345 NCBI chr 8:68,055,976...68,282,656
Ensembl chr 8:68,055,972...68,282,590 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression EXP Clozapine results in increased expression of MAP3K1 mRNA CTD PMID:15860345 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207 		JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 increases expression EXP Clozapine results in increased expression of MAP3K12 mRNA CTD PMID:15860345 NCBI chr 7:144,102,275...144,120,306
Ensembl chr 7:144,102,680...144,109,116 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases expression
decreases phosphorylation		 ISO
EXP		 Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]
Clozapine results in decreased expression of MAPK1 mRNA
Clozapine results in decreased phosphorylation of MAPK1 protein		 CTD PMID:12871586, PMID:15860345 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects expression EXP Clozapine affects the expression of MAPK14 mRNA CTD PMID:15860345 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions		 ISO Clozapine results in decreased phosphorylation of MAPK3 protein
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]		 CTD PMID:12871586 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk6 mitogen-activated protein kinase 6 affects expression EXP Clozapine affects the expression of MAPK6 mRNA CTD PMID:15860345 NCBI chr 8:82,328,013...82,351,108
Ensembl chr 8:82,328,020...82,351,108 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 increases expression ISO Clozapine results in increased expression of MAPK8IP1 mRNA CTD PMID:17266109 NCBI chr 3:81,295,023...81,304,181
Ensembl chr 3:81,295,024...81,304,181 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 affects expression EXP Clozapine affects the expression of MAPK9 mRNA CTD PMID:15860345 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor decreases expression EXP Clozapine results in decreased expression of MAS1 mRNA CTD PMID:16715494 NCBI chr 1:48,076,761...48,108,218
Ensembl chr 1:48,077,033...48,108,216 		JBrowse link
G Mbp myelin basic protein increases expression ISO Clozapine results in increased expression of MBP mRNA CTD PMID:17266109, PMID:17346280 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310 		JBrowse link
G Mc1r melanocortin 1 receptor increases expression ISO Clozapine results in increased expression of MC1R mRNA CTD PMID:17346280 NCBI chr19:56,215,420...56,219,987 JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase increases expression ISO Clozapine results in increased expression of MLKL protein CTD PMID:31220554 NCBI chr19:43,508,416...43,535,050
Ensembl chr19:43,506,976...43,528,851 		JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Clozapine results in decreased expression of MMP10 mRNA CTD PMID:17346280 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO Clozapine results in decreased expression of MMP7 mRNA CTD PMID:17346280 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049 		JBrowse link
G Mobp myelin-associated oligodendrocyte basic protein increases expression ISO Clozapine results in increased expression of MOBP mRNA CTD PMID:15542763, PMID:17266109 NCBI chr 8:128,824,420...128,854,492
Ensembl chr 8:128,824,508...128,850,358 		JBrowse link
G Mpo myeloperoxidase affects response to substance ISO MPO protein affects the susceptibility to Clozapine CTD PMID:24588327 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Mpp3 membrane palmitoylated protein 3 decreases expression ISO Clozapine results in decreased expression of MPP3 mRNA CTD PMID:17266109 NCBI chr10:89,930,270...89,959,462
Ensembl chr10:89,930,241...89,959,176 		JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Clozapine affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR gene polymorphism affects the susceptibility to Clozapine; MTHFR protein affects the susceptibility to Clozapine CTD PMID:20547447 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910 		JBrowse link
G Ncan neurocan decreases expression ISO Clozapine results in decreased expression of NCAN mRNA CTD PMID:18797397 NCBI chr16:21,050,243...21,076,707
Ensembl chr16:21,050,243...21,076,707 		JBrowse link
G Ncl nucleolin increases expression ISO Clozapine results in increased expression of NCL mRNA CTD PMID:14647396 NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643 		JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression EXP Clozapine results in increased expression of NDUFV2 mRNA CTD PMID:19441803 NCBI chr 9:113,875,718...113,900,169
Ensembl chr 9:113,875,703...113,900,190 		JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase decreases expression ISO Clozapine results in decreased expression of NEDD4 mRNA CTD PMID:18797397 NCBI chr 8:79,323,408...79,408,842
Ensembl chr 8:79,323,408...79,408,833 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to Clozapine CTD PMID:21540358 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression EXP Clozapine results in decreased expression of NFKB1 protein CTD PMID:16500086 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Ngfr nerve growth factor receptor decreases expression ISO
EXP		 Clozapine results in decreased expression of NGFR protein; Clozapine results in decreased expression of NGFR protein alternative form
Clozapine results in decreased expression of NGFR mRNA		 CTD PMID:12111809, PMID:14598305, PMID:16513140 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061 		JBrowse link
G Nop53 NOP53 ribosome biogenesis factor affects expression ISO Clozapine affects the expression of NOP53 mRNA CTD PMID:14647396 NCBI chr 1:77,836,522...77,843,991
Ensembl chr 1:77,836,196...77,844,189 		JBrowse link
G Nptn neuroplastin increases expression ISO Clozapine results in increased expression of NPTN mRNA CTD PMID:18797397 NCBI chr 8:63,379,062...63,445,694
Ensembl chr 8:63,379,087...63,445,686 		JBrowse link
G Nptx2 neuronal pentraxin 2 decreases expression EXP Clozapine results in decreased expression of NPTX2 mRNA CTD PMID:18208916 NCBI chr12:12,014,638...12,025,547
Ensembl chr12:12,013,911...12,025,549 		JBrowse link
G Npy neuropeptide Y decreases expression EXP Clozapine results in decreased expression of NPY mRNA CTD PMID:16516965 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 affects response to substance
increases reduction
multiple interactions		 ISO NQO2 gene SNP affects the susceptibility to Clozapine
NQO2 protein results in increased reduction of Clozapine metabolite
Clozapine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3]		 CTD PMID:14617031, PMID:29281794 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Clozapine results in increased expression of NR0B2 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] CTD PMID:21402137 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Clozapine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein] CTD PMID:16581232 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression
decreases expression		 EXP Clozapine results in increased expression of NR4A1 mRNA
Clozapine results in decreased expression of NR4A1 mRNA		 CTD PMID:10987852, PMID:11564422, PMID:19695244 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO Clozapine results in increased expression of NR4A2 mRNA CTD PMID:17266109 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159 		JBrowse link
G Nrg1 neuregulin 1 increases expression
affects expression
affects response to substance		 ISO
EXP		 Clozapine results in increased expression of NRG1 mRNA
Clozapine affects the expression of NRG1 protein
NRG1 protein affects the susceptibility to Clozapine		 CTD PMID:15706234, PMID:18184445, PMID:19502011 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434 		JBrowse link
G Ntng2 netrin G2 increases expression EXP Clozapine results in increased expression of NTNG2 mRNA CTD PMID:17507910 NCBI chr 3:7,742,511...7,800,834
Ensembl chr 3:7,742,531...7,796,385 		JBrowse link
G Nts neurotensin increases expression EXP Clozapine results in increased expression of NTS mRNA CTD PMID:12887421 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130 		JBrowse link
G Numbl NUMB-like, endocytic adaptor protein decreases expression ISO Clozapine results in decreased expression of NUMBL mRNA CTD PMID:18797397 NCBI chr 1:84,067,841...84,091,659
Ensembl chr 1:84,067,938...84,091,671 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Clozapine results in increased expression of NUPR1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524 		JBrowse link
G Osbpl8 oxysterol binding protein-like 8 increases expression ISO Clozapine results in increased expression of OSBPL8 mRNA CTD PMID:14647396 NCBI chr 7:53,878,906...54,030,110
Ensembl chr 7:53,878,610...54,027,892 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide affects response to substance ISO OXT protein affects the susceptibility to Clozapine CTD PMID:20196918 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534 		JBrowse link
G Park7 Parkinsonism associated deglycase increases expression ISO Clozapine results in increased expression of PARK7 mRNA CTD PMID:14647396 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724 		JBrowse link
G Pcm1 pericentriolar material 1 decreases expression ISO Clozapine results in decreased expression of PCM1 mRNA CTD PMID:19048012 NCBI chr16:54,040,721...54,137,675
Ensembl chr16:54,040,721...54,137,660 		JBrowse link
G Pde10a phosphodiesterase 10A increases expression ISO
EXP		 Clozapine results in increased expression of PDE10A mRNA
Clozapine results in increased expression of PDE10A mRNA; Clozapine results in increased expression of PDE10A protein		 CTD PMID:17266109, PMID:18222493 NCBI chr 1:52,360,296...52,544,448
Ensembl chr 1:52,360,296...52,544,450 		JBrowse link
G Pde1b phosphodiesterase 1B increases expression ISO Clozapine results in increased expression of PDE1B mRNA CTD PMID:14647396 NCBI chr 7:145,117,951...145,147,711
Ensembl chr 7:145,117,951...145,145,376 		JBrowse link
G Pde4a phosphodiesterase 4A decreases expression EXP Clozapine results in decreased expression of PDE4A protein CTD PMID:20222156 NCBI chr 8:22,189,533...22,234,036
Ensembl chr 8:22,189,600...22,233,748 		JBrowse link
G Pde4b phosphodiesterase 4B decreases expression
increases expression		 EXP Clozapine results in decreased expression of PDE4B protein
Clozapine results in increased expression of PDE4B mRNA; Clozapine results in increased expression of PDE4B protein		 CTD PMID:18222493, PMID:20222156 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814 		JBrowse link
G Penk proenkephalin decreases expression
increases expression		 EXP Clozapine results in decreased expression of PENK mRNA
Clozapine results in increased expression of PENK mRNA		 CTD PMID:1635659, PMID:12887421 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837 		JBrowse link
G Pfdn5 prefoldin subunit 5 increases expression ISO Clozapine results in increased expression of PFDN5 mRNA CTD PMID:14647396 NCBI chr 7:143,924,662...143,929,400
Ensembl chr 7:143,924,662...143,929,397 		JBrowse link
G Pfkp phosphofructokinase, platelet increases expression EXP Clozapine results in increased expression of PFKP mRNA CTD PMID:15860345 NCBI chr17:68,510,765...68,574,387
Ensembl chr17:68,511,064...68,559,471 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression EXP Clozapine results in increased expression of PGK1 mRNA CTD PMID:15860345 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367 		JBrowse link
G Phactr1 phosphatase and actin regulator 1 increases expression ISO Clozapine results in increased expression of PHACTR1 mRNA CTD PMID:14647396 NCBI chr17:23,245,423...23,761,207 JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 decreases expression EXP Clozapine results in decreased expression of PIK3R3 mRNA CTD PMID:16715494 NCBI chr 5:135,069,972...135,145,633
Ensembl chr 5:135,074,297...135,142,488 		JBrowse link
G Pkib cAMP-dependent protein kinase inhibitor beta decreases expression EXP Clozapine results in decreased expression of PKIB mRNA CTD PMID:15860345 NCBI chr20:40,616,868...40,712,598
Ensembl chr20:40,618,128...40,712,592 		JBrowse link
G Pkm pyruvate kinase M1/2 increases expression EXP Clozapine results in increased expression of PKM mRNA CTD PMID:15860345 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722 		JBrowse link
G Plcb1 phospholipase C beta 1 increases expression ISO Clozapine results in increased expression of PLCB1 mRNA CTD PMID:16465460 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545 		JBrowse link
G Plp1 proteolipid protein 1 decreases expression
increases expression		 ISO Clozapine results in decreased expression of PLP1 mRNA
Clozapine results in increased expression of PLP1 mRNA		 CTD PMID:17266109, PMID:18797397 NCBI chr  X:107,494,326...107,511,355
Ensembl chr  X:107,496,072...107,511,348 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]
Clozapine results in increased expression of PPARG mRNA; Clozapine results in increased expression of PPARG protein		 CTD PMID:20564506 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A decreases expression EXP Clozapine results in decreased expression of PPM1A mRNA CTD PMID:15860345 NCBI chr 6:94,433,658...94,484,979
Ensembl chr 6:94,429,068...94,484,351 		JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B decreases expression EXP Clozapine results in decreased expression of PPM1B mRNA CTD PMID:15860345 NCBI chr 6:8,219,385...8,280,127
Ensembl chr 6:8,218,696...8,280,124 		JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta decreases expression EXP Clozapine results in decreased expression of PPP1CB mRNA CTD PMID:15860345 NCBI chr 6:23,548,507...23,581,136
Ensembl chr 6:23,549,317...23,581,052 		JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma decreases expression EXP Clozapine results in decreased expression of PPP1CC mRNA CTD PMID:15860345 NCBI chr12:39,864,302...39,882,030
Ensembl chr12:39,864,295...39,882,030 		JBrowse link
G Ppp1r1a protein phosphatase 1, regulatory (inhibitor) subunit 1A decreases expression EXP Clozapine results in decreased expression of PPP1R1A mRNA CTD PMID:15860345 NCBI chr 7:145,146,480...145,154,131
Ensembl chr 7:145,146,481...145,154,131 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions
increases phosphorylation		 ISO Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]
Clozapine results in increased phosphorylation of PPP1R1B protein		 CTD PMID:11880652, PMID:12871586 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762 		JBrowse link
G Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 decreases expression EXP Clozapine results in decreased expression of PPP1R2 mRNA CTD PMID:15860345 NCBI chr11:72,748,789...73,034,683
Ensembl chr11:73,022,063...73,034,682 		JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B increases expression EXP Clozapine results in increased expression of PPP1R9B protein CTD PMID:16844384 NCBI chr10:82,800,704...82,816,735
Ensembl chr10:82,800,704...82,816,731 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha decreases expression EXP Clozapine results in decreased expression of PPP2CA mRNA CTD PMID:15860345 NCBI chr10:37,534,449...37,554,861
Ensembl chr10:37,535,871...37,554,664 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression EXP Clozapine results in decreased expression of PPP2CB mRNA CTD PMID:15860345 NCBI chr16:62,273,276...62,294,767
Ensembl chr16:62,273,276...62,294,769 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression EXP Clozapine results in increased expression of PPP2R1A mRNA CTD PMID:15860345 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha decreases expression EXP Clozapine results in decreased expression of PPP2R2A mRNA CTD PMID:15860345 NCBI chr15:43,673,958...43,733,182
Ensembl chr15:43,673,960...43,733,182 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions
increases expression
decreases expression		 EXP [Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein
Clozapine results in increased expression of PPP3CA mRNA
Clozapine results in decreased expression of PPP3CA mRNA; Clozapine results in decreased expression of PPP3CA protein		 CTD PMID:12437575, PMID:16033416 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854 		JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit affects expression ISO Clozapine affects the expression of PPP5C mRNA CTD PMID:14647396 NCBI chr 1:78,944,054...78,968,361
Ensembl chr 1:78,944,040...78,968,329 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases expression EXP Clozapine results in increased expression of PRKACA mRNA CTD PMID:15860345 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta decreases expression
increases expression		 EXP Clozapine results in decreased expression of PRKACB mRNA; Clozapine results in decreased expression of PRKACB protein
Clozapine results in increased expression of PRKACB mRNA		 CTD PMID:11907174, PMID:15860345 NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886 		JBrowse link
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha multiple interactions
decreases expression		 EXP Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2A protein]
Clozapine results in decreased expression of PRKAR2A mRNA; Clozapine results in decreased expression of PRKAR2A protein		 CTD PMID:11907174 NCBI chr 8:117,486,085...117,548,768
Ensembl chr 8:117,486,083...117,546,370 		JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta decreases expression
multiple interactions		 EXP Clozapine results in decreased expression of PRKAR2B mRNA; Clozapine results in decreased expression of PRKAR2B protein
Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2B protein]		 CTD PMID:11907174, PMID:15860345 NCBI chr 6:51,265,509...51,356,383
Ensembl chr 6:51,265,515...51,356,383 		JBrowse link
G Prkcb protein kinase C, beta affects expression
increases expression		 EXP Clozapine affects the expression of PRKCB protein
Clozapine results in increased expression of PRKCB mRNA		 CTD PMID:15860345, PMID:15967061 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831 		JBrowse link
G Prkce protein kinase C, epsilon increases expression EXP Clozapine results in increased expression of PRKCE mRNA CTD PMID:15860345 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396 		JBrowse link
G Prkcz protein kinase C, zeta increases expression EXP Clozapine results in increased expression of PRKCZ mRNA CTD PMID:15860345 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421 		JBrowse link
G Prl prolactin increases secretion
increases expression
multiple interactions		 ISO
EXP		 Clozapine results in increased secretion of PRL protein
Clozapine analog results in increased expression of PRL protein
[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein; [Risperidone co-treated with Clozapine] results in increased expression of PRL protein		 CTD PMID:11155212, PMID:11997696, PMID:15286066, PMID:18562423 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa increases expression ISO Clozapine results in increased expression of PROC protein CTD PMID:20126316 NCBI chr18:24,918,402...24,928,822
Ensembl chr18:24,918,398...24,929,091 		JBrowse link
G Prpf38b pre-mRNA processing factor 38B decreases expression ISO Clozapine results in decreased expression of PRPF38B mRNA CTD PMID:14647396 NCBI chr 2:211,706,245...211,715,271
Ensembl chr 2:211,706,228...211,715,311 		JBrowse link
G Prrc2a proline-rich coiled-coil 2A decreases expression ISO Clozapine results in decreased expression of PRRC2A mRNA CTD PMID:18797397 NCBI chr20:5,139,881...5,155,371
Ensembl chr20:5,139,882...5,155,293 		JBrowse link
G Ptgds prostaglandin D2 synthase decreases expression
increases expression		 ISO Clozapine results in decreased expression of PTGDS mRNA
Clozapine results in increased expression of PTGDS mRNA		 CTD PMID:15542763, PMID:17266109 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084 		JBrowse link
G Ptms parathymosin increases expression ISO Clozapine results in increased expression of PTMS mRNA CTD PMID:14647396 NCBI chr 4:157,435,371...157,439,507
Ensembl chr 4:157,435,373...157,439,507 		JBrowse link
G Pvalb parvalbumin multiple interactions EXP Clozapine inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA] CTD PMID:12589379 NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487 		JBrowse link
G Rab12 RAB12, member RAS oncogene family decreases expression EXP Clozapine results in decreased expression of RAB12 mRNA CTD PMID:12437575 NCBI chr 9:114,683,985...114,709,613
Ensembl chr 9:114,684,039...114,709,546 		JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO Clozapine results in decreased expression of RAPGEF4 mRNA CTD PMID:18797397 NCBI chr 3:58,632,338...58,925,127
Ensembl chr 3:58,632,476...58,924,038 		JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 affects expression EXP Clozapine affects the expression of RASGRF1 mRNA CTD PMID:12437575 NCBI chr 8:97,277,250...97,405,095
Ensembl chr 8:97,277,456...97,405,102 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression EXP Clozapine results in decreased expression of RELA protein CTD PMID:16500086 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Reln reelin decreases expression
multiple interactions
decreases methylation		 ISO
EXP		 Clozapine results in decreased expression of RELN mRNA
Clozapine results in decreased expression of RELN protein
Valproic Acid promotes the reaction [Clozapine results in decreased methylation of RELN promoter]		 CTD PMID:17266109, PMID:18757738, PMID:19359144 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression EXP
ISO		 Clozapine results in increased expression of RGS4 mRNA CTD PMID:15860345, PMID:17266109 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108 		JBrowse link
G Rgs7 regulator of G-protein signaling 7 multiple interactions
increases expression		 EXP [[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]
Clozapine results in increased expression of RGS7 mRNA		 CTD PMID:18976543 NCBI chr13:93,095,659...93,534,452
Ensembl chr13:93,095,200...93,307,199 		JBrowse link
G Rgs8 regulator of G-protein signaling 8 increases expression EXP Clozapine results in increased expression of RGS8 mRNA CTD PMID:15860345 NCBI chr13:71,086,654...71,141,820
Ensembl chr13:71,086,745...71,141,075 		JBrowse link
G Rorb RAR-related orphan receptor B decreases expression EXP Clozapine results in decreased expression of RORB mRNA CTD PMID:11564422 NCBI chr 1:234,252,757...234,442,597
Ensembl chr 1:234,252,757...234,435,839 		JBrowse link
G Rplp2 ribosomal protein lateral stalk subunit P2 increases expression ISO Clozapine results in increased expression of RPLP2 mRNA CTD PMID:14647396 NCBI chr 1:214,428,280...214,430,551
Ensembl chr 1:214,428,526...214,430,515 		JBrowse link
G Rps10 ribosomal protein S10 increases expression ISO Clozapine results in increased expression of RPS10 mRNA CTD PMID:14647396 NCBI chr20:7,215,762...7,220,331
Ensembl chr20:7,215,774...7,219,548 		JBrowse link
G Rtn4 reticulon 4 increases expression ISO Clozapine results in increased expression of RTN4 mRNA CTD PMID:17266109 NCBI chr14:114,126,931...114,174,459
Ensembl chr14:114,126,943...114,174,458 		JBrowse link
G Rxrg retinoid X receptor gamma decreases expression EXP Clozapine results in decreased expression of RXRG mRNA alternative form CTD PMID:11564422 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552 		JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression ISO Clozapine results in decreased expression of S100A9 mRNA CTD PMID:18797397 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276 		JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Clozapine results in increased expression of SC5D mRNA CTD PMID:17052361 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Clozapine results in increased expression of SCD mRNA CTD PMID:16027736, PMID:17052361 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO Clozapine results in increased expression of SERPINA3 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055 		JBrowse link
G Serpine2 serpin family E member 2 increases expression EXP Clozapine results in increased expression of SERPINE2 mRNA; Clozapine results in increased expression of SERPINE2 protein CTD PMID:15354176 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO
EXP		 Clozapine results in increased expression of SGK1 mRNA CTD PMID:17266109, PMID:18208916 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298 		JBrowse link
G Slc17a6 solute carrier family 17 member 6 increases expression ISO Clozapine results in increased expression of SLC17A6 mRNA; Clozapine results in increased expression of SLC17A6 protein CTD PMID:17266109, PMID:18155072 NCBI chr 1:106,980,463...107,038,717
Ensembl chr 1:106,998,623...107,038,704 		JBrowse link
G Slc17a7 solute carrier family 17 member 7 increases expression ISO Clozapine results in increased expression of SLC17A7 mRNA; Clozapine results in increased expression of SLC17A7 protein CTD PMID:16111724 NCBI chr 1:101,161,265...101,172,292
Ensembl chr 1:101,161,252...101,173,174 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 increases expression EXP Clozapine results in increased expression of SLC18A2 mRNA; Clozapine results in increased expression of SLC18A2 protein CTD PMID:12007678 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases expression EXP Clozapine results in decreased expression of SLC1A1 mRNA CTD PMID:12873733 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 decreases activity
decreases expression		 EXP Clozapine results in decreased activity of SLC1A2 protein
Clozapine results in decreased expression of SLC1A2 mRNA; Clozapine results in decreased expression of SLC1A2 protein		 CTD PMID:11443521, PMID:12873733 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Clozapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Clozapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:30465787 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Clozapine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856 		JBrowse link
G Slc39a7 solute carrier family 39 member 7 increases expression ISO Clozapine results in increased expression of SLC39A7 mRNA CTD PMID:14647396 NCBI chr20:3,819,416...3,822,788
Ensembl chr20:3,819,414...3,822,778 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 decreases expression EXP Clozapine results in decreased expression of SLC6A2 mRNA CTD PMID:18923069 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 affects response to substance ISO SLC6A3 5' UTR affects the susceptibility to Clozapine CTD PMID:20580759 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions
increases expression
affects response to substance		 ISO
EXP		 [SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapine
Clozapine results in increased expression of SLC6A4
SLC6A4 protein affects the susceptibility to Clozapine		 CTD PMID:12007678, PMID:20452607 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463 		JBrowse link
G Snap25 synaptosome associated protein 25 increases expression
affects response to substance		 EXP
ISO		 Clozapine results in increased expression of SNAP25 mRNA
SNAP25 gene SNP affects the susceptibility to Clozapine		 CTD PMID:15823421, PMID:15860345 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400 		JBrowse link
G Snrpd2 small nuclear ribonucleoprotein D2 polypeptide increases expression ISO Clozapine results in increased expression of SNRPD2 mRNA CTD PMID:14647396 NCBI chr 1:80,057,140...80,059,990
Ensembl chr 1:80,056,755...80,059,996 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions		 EXP Clozapine results in increased expression of SOD1 mRNA
Clozapine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; Clozapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]		 CTD PMID:12111809, PMID:12752374, PMID:16564057 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression EXP Clozapine results in decreased expression of SOD2 mRNA CTD PMID:15860345 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sod3 superoxide dismutase 3 increases expression EXP Clozapine results in increased expression of SOD3 mRNA CTD PMID:15860345 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression
increases expression		 EXP Clozapine results in decreased expression of SOS1 mRNA
Clozapine results in increased expression of SOS1 mRNA		 CTD PMID:12437575 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO Clozapine results in decreased expression of SPP1 mRNA CTD PMID:17346280 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions		 ISO Clozapine results in increased expression of SREBF1 mRNA
Clozapine results in increased expression of SREBF1 mRNA; Clozapine results in increased expression of SREBF1 protein
Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]		 CTD PMID:17052361, PMID:19682446, PMID:20564506 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions
increases expression		 ISO Clozapine inhibits the reaction [25-hydroxycholesterol results in decreased activity of SREBF2 protein]; Clozapine results in increased cleavage of and results in increased activity of SREBF2 protein
Clozapine results in increased expression of SREBF2 mRNA		 CTD PMID:17052361 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603 		JBrowse link
G Sst somatostatin multiple interactions EXP Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein] CTD PMID:16567023 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444 		JBrowse link
G Strn4 striatin 4 increases expression ISO Clozapine results in increased expression of STRN4 mRNA CTD PMID:14647396 NCBI chr 1:78,739,930...78,765,696
Ensembl chr 1:78,735,678...78,765,692 		JBrowse link
G Stx1a syntaxin 1A increases expression EXP Clozapine results in increased expression of STX1A mRNA CTD PMID:15860345 NCBI chr12:24,682,050...24,710,002
Ensembl chr12:24,682,041...24,710,019 		JBrowse link
G Stx1b syntaxin 1B increases expression EXP Clozapine results in increased expression of STX1B mRNA CTD PMID:15860345 NCBI chr 1:199,251,842...199,270,465
Ensembl chr 1:199,251,844...199,270,627 		JBrowse link
G Stx4 syntaxin 4 increases expression EXP Clozapine results in increased expression of STX4 mRNA CTD PMID:15860345 NCBI chr 1:199,287,384...199,295,606
Ensembl chr 1:199,287,710...199,294,979 		JBrowse link
G Stx8 syntaxin 8 affects expression EXP Clozapine affects the expression of STX8 mRNA CTD PMID:15860345 NCBI chr10:54,512,922...54,753,302
Ensembl chr10:54,512,983...54,753,302 		JBrowse link
G Stxbp1 syntaxin binding protein 1 affects expression EXP Clozapine affects the expression of STXBP1 mRNA CTD PMID:12437575 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417 		JBrowse link
G Supt3h SPT3 homolog, SAGA and STAGA complex component increases expression EXP Clozapine results in increased expression of SUPT3H mRNA CTD PMID:16715494 NCBI chr 9:18,249,565...18,604,814
Ensembl chr 9:18,319,246...18,371,856 		JBrowse link
G Syn2 synapsin II decreases expression
increases expression		 ISO
EXP		 Clozapine results in decreased expression of SYN2 mRNA
Clozapine results in increased expression of SYN2 mRNA		 CTD PMID:15860345, PMID:17266109 NCBI chr 4:147,037,179...147,195,096
Ensembl chr 4:147,037,179...147,195,096 		JBrowse link
G Syt11 synaptotagmin 11 increases expression EXP Clozapine results in increased expression of SYT11 mRNA CTD PMID:15860345 NCBI chr 2:188,112,301...188,138,180
Ensembl chr 2:188,112,286...188,138,177 		JBrowse link
G Syt2 synaptotagmin 2 increases expression ISO Clozapine results in increased expression of SYT2 mRNA CTD PMID:17266109 NCBI chr13:51,569,248...51,577,824
Ensembl chr13:51,534,025...51,578,052 		JBrowse link
G Syt4 synaptotagmin 4 increases expression EXP Clozapine results in increased expression of SYT4 mRNA CTD PMID:15860345 NCBI chr18:24,172,580...24,181,989
Ensembl chr18:24,172,587...24,182,012 		JBrowse link
G Syt5 synaptotagmin 5 decreases expression EXP Clozapine results in decreased expression of SYT5 mRNA CTD PMID:12437575 NCBI chr 1:72,859,806...72,867,934
Ensembl chr 1:72,860,218...72,867,930 		JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression ISO
EXP		 Clozapine results in decreased expression of TAC1 mRNA CTD PMID:10974607, PMID:17266109 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819 		JBrowse link
G Tagln transgelin decreases expression ISO Clozapine results in decreased expression of TAGLN mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357 		JBrowse link
G Tatdn1 TatD DNase domain containing 1 increases expression ISO Clozapine results in increased expression of TATDN1 mRNA CTD PMID:14647396 NCBI chr 7:98,782,164...98,813,001
Ensembl chr 7:98,782,178...98,804,499 		JBrowse link
G Th tyrosine hydroxylase decreases activity
multiple interactions
increases expression
decreases expression
increases activity		 EXP
ISO		 Clozapine results in decreased activity of TH protein
Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]
Clozapine results in increased expression of TH protein
Clozapine results in decreased expression of TH mRNA; Clozapine results in decreased expression of TH protein
Clozapine results in increased activity of TH protein
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]; [Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine		 CTD PMID:12645084, PMID:15983997, PMID:16402076, PMID:16415089, PMID:17028028 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Thra thyroid hormone receptor alpha decreases expression
increases expression		 EXP Clozapine results in decreased expression of THRA mRNA alternative form
Clozapine results in increased expression of THRA mRNA alternative form		 CTD PMID:11564422 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933 		JBrowse link
G Thrb thyroid hormone receptor beta decreases expression EXP Clozapine results in decreased expression of THRB mRNA alternative form CTD PMID:11564422 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282 		JBrowse link
G Tnf tumor necrosis factor affects response to substance
increases expression		 ISO
EXP		 TNF protein affects the susceptibility to Clozapine
Clozapine results in increased expression of TNF protein		 CTD PMID:20521320, PMID:24709159 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfsf15 TNF superfamily member 15 decreases expression ISO Clozapine results in decreased expression of TNFSF15 mRNA CTD PMID:17346280 NCBI chr 5:79,553,935...79,569,974
Ensembl chr 5:79,553,742...79,570,073 		JBrowse link
G Tnik TRAF2 and NCK interacting kinase decreases expression ISO Clozapine results in decreased expression of TNIK mRNA CTD PMID:14647396 NCBI chr 2:113,984,599...114,391,805
Ensembl chr 2:113,984,646...114,384,894 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO Clozapine results in increased expression of TP53 mRNA
CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA]		 CTD PMID:16160616 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP Clozapine results in increased expression of TPI1 mRNA CTD PMID:15860345 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905 		JBrowse link
G Trim2 tripartite motif-containing 2 decreases expression ISO Clozapine results in decreased expression of TRIM2 mRNA CTD PMID:14647396 NCBI chr 2:183,145,096...183,223,819
Ensembl chr 2:183,145,089...183,213,228 		JBrowse link
G Ttr transthyretin decreases expression
increases expression		 ISO
EXP		 Clozapine results in decreased expression of TTR mRNA
Clozapine results in increased expression of TTR mRNA; Clozapine results in increased expression of TTR protein		 CTD PMID:15927202, PMID:17266109 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177 		JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 increases expression ISO Clozapine results in increased expression of UBA52 mRNA CTD PMID:14647396 NCBI chr16:20,668,925...20,671,127
Ensembl chr16:20,668,971...20,671,127 		JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 affects expression ISO Clozapine affects the expression of UBE2R2 mRNA CTD PMID:14647396 NCBI chr 5:57,472,315...57,530,973
Ensembl chr 5:57,472,315...57,530,987 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO Clozapine results in increased expression of UGT1A1 mRNA CTD PMID:18227147 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein SNP results in increased glucuronidation of Clozapine CTD PMID:15708967 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Unc13a unc-13 homolog A decreases expression EXP Clozapine results in decreased expression of UNC13A mRNA CTD PMID:15860345 NCBI chr16:20,056,398...20,103,951
Ensembl chr16:20,056,765...20,097,287 		JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI affects expression ISO Clozapine affects the expression of UQCR11 mRNA CTD PMID:14647396 NCBI chr 7:12,171,146...12,175,838
Ensembl chr 7:12,171,185...12,175,835 		JBrowse link
G Vamp1 vesicle-associated membrane protein 1 increases expression EXP Clozapine results in increased expression of VAMP1 mRNA CTD PMID:15860345 NCBI chr 4:157,726,941...157,733,644
Ensembl chr 4:157,726,941...157,733,643 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 increases expression EXP Clozapine results in increased expression of VAMP2 mRNA CTD PMID:15860345 NCBI chr10:55,675,171...55,679,405
Ensembl chr10:55,675,575...55,679,450 		JBrowse link
G Vsnl1 visinin-like 1 decreases expression EXP Clozapine results in decreased expression of VSNL1 mRNA CTD PMID:12437575 NCBI chr 6:37,001,360...37,121,969
Ensembl chr 6:37,001,356...37,122,023 		JBrowse link
G Wbp1l WW domain binding protein 1-like decreases expression ISO Clozapine results in decreased expression of WBP1L mRNA CTD PMID:14647396 NCBI chr 1:266,358,728...266,415,296
Ensembl chr 1:266,358,728...266,415,296 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Clozapine results in increased expression of WIPI1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525 		JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta decreases expression ISO Clozapine results in decreased expression of YWHAB mRNA CTD PMID:17266109 NCBI chr 3:160,391,108...160,399,931
Ensembl chr 3:160,391,106...160,399,931 		JBrowse link
diethylcarbamazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases activity ISO Diethylcarbamazine results in increased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
olanzapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A1bg alpha-1-B glycoprotein affects phosphorylation ISO olanzapine affects the phosphorylation of A1BG protein CTD PMID:25821032 NCBI chr 7:102,294,805...102,298,522
Ensembl chr 7:102,294,797...102,298,522 		JBrowse link
G A2m alpha-2-macroglobulin affects phosphorylation ISO olanzapine affects the phosphorylation of A2M protein CTD PMID:25821032 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO olanzapine results in decreased activity of ABCB11 protein CTD PMID:22646477 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO olanzapine results in decreased activity of ABCB1 protein CTD PMID:16810505 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO olanzapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] CTD PMID:18834354 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression
multiple interactions		 ISO Olanzapine results in decreased expression of ACACA mRNA
capsazepine inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]		 CTD PMID:32652086 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA CTD PMID:23226405 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050 		JBrowse link
G Adcyap1r1 ADCYAP receptor type I affects expression ISO olanzapine affects the expression of ADCYAP1R1 mRNA CTD PMID:27900577 NCBI chr 4:85,662,809...85,711,696
Ensembl chr 4:85,662,892...85,711,696 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
decreases expression
multiple interactions		 ISO olanzapine results in increased expression of ADIPOQ mRNA
Olanzapine results in decreased expression of ADIPOQ protein
capsazepine inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]; Metformin inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]		 CTD PMID:17651982, PMID:32652086 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Afm afamin affects phosphorylation ISO olanzapine affects the phosphorylation of AFM protein CTD PMID:25821032 NCBI chr14:19,078,678...19,132,212
Ensembl chr14:19,078,680...19,132,208 		JBrowse link
G Agrp agouti related neuropeptide increases expression
multiple interactions		 EXP
ISO		 olanzapine results in increased expression of AGRP protein
Metformin inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA]		 CTD PMID:21695181, PMID:32652086 NCBI chr19:37,525,941...37,584,875
Ensembl chr19:37,526,419...37,528,011 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
decreases expression
multiple interactions
increases response to substance
increases phosphorylation		 ISO Olanzapine results in increased expression of AKT1 mRNA; Olanzapine results in increased expression of AKT1 protein
Olanzapine results in decreased expression of AKT1 mRNA
capsazepine inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]
AKT1 gene SNP results in increased susceptibility to olanzapine
olanzapine results in increased phosphorylation of AKT1 protein		 CTD PMID:19440698, PMID:21187413, PMID:32652086 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alb albumin affects phosphorylation ISO olanzapine affects the phosphorylation of ALB protein CTD PMID:25821032 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Apoa1 apolipoprotein A1 increases phosphorylation ISO olanzapine results in increased phosphorylation of APOA1 protein CTD PMID:25821032 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Apoa4 apolipoprotein A4 affects phosphorylation ISO olanzapine affects the phosphorylation of APOA4 protein CTD PMID:25821032 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376 		JBrowse link
G Apob apolipoprotein B increases phosphorylation ISO olanzapine results in increased phosphorylation of APOB protein CTD PMID:25821032 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997 		JBrowse link
G Apoc3 apolipoprotein C3 affects response to substance EXP APOC3 gene polymorphism affects the susceptibility to olanzapine CTD PMID:17726453 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498 		JBrowse link
G Apoh apolipoprotein H affects phosphorylation ISO olanzapine affects the phosphorylation of APOH protein CTD PMID:25821032 NCBI chr10:96,640,013...96,653,939
Ensembl chr10:96,639,924...96,653,938 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP olanzapine inhibits the reaction [APP protein modified form affects the activity of CAT protein]; olanzapine inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species] CTD PMID:15948179 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Aqp4 aquaporin 4 affects response to substance
increases response to substance		 ISO AQP4 gene polymorphism affects the susceptibility to olanzapine
AQP4 protein results in increased susceptibility to olanzapine		 CTD PMID:22544010 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP olanzapine results in increased expression of BAX protein CTD PMID:16462815 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression		 EXP olanzapine inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]
olanzapine results in increased expression of BCL2 mRNA; olanzapine results in increased expression of BCL2 protein		 CTD PMID:15126120, PMID:15276877 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP
ISO		 olanzapine results in increased expression of BDNF mRNA; olanzapine results in increased expression of BDNF protein
Olanzapine results in increased expression of BDNF mRNA; Olanzapine results in increased expression of BDNF protein		 CTD PMID:12478621, PMID:17442489, PMID:29182611 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Bik BCL2-interacting killer increases expression ISO olanzapine results in increased expression of BIK mRNA CTD PMID:16160616 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447 		JBrowse link
G C3 complement C3 affects phosphorylation ISO olanzapine affects the phosphorylation of C3 protein CTD PMID:25821032 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167 		JBrowse link
G C4a complement C4A decreases phosphorylation ISO olanzapine results in decreased phosphorylation of C4A protein CTD PMID:25821032 NCBI chr20:2,651,599...2,678,183
Ensembl chr20:2,651,599...2,678,141 		JBrowse link
G C4b complement C4B (Chido blood group) affects phosphorylation ISO olanzapine affects the phosphorylation of C4B protein CTD PMID:25821032 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715 		JBrowse link
G C5 complement C5 affects phosphorylation ISO olanzapine affects the phosphorylation of C5 protein CTD PMID:25821032 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080 		JBrowse link
G C6 complement C6 affects phosphorylation ISO olanzapine affects the phosphorylation of C6 protein CTD PMID:25821032 NCBI chr 2:54,460,333...54,533,801
Ensembl chr 2:54,466,280...54,533,797 		JBrowse link
G C9 complement C9 affects phosphorylation ISO olanzapine affects the phosphorylation of C9 protein CTD PMID:25821032 NCBI chr 2:55,775,562...55,823,807
Ensembl chr 2:55,775,274...55,823,826 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP olanzapine results in decreased expression of and results in decreased phosphorylation of CAMK2A protein CTD PMID:18061412 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869 		JBrowse link
G Cat catalase multiple interactions EXP olanzapine inhibits the reaction [APP protein modified form affects the activity of CAT protein] CTD PMID:15948179 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cfb complement factor B affects phosphorylation ISO olanzapine affects the phosphorylation of CFB protein CTD PMID:25821032 NCBI chr20:4,536,206...4,542,073
Ensembl chr20:4,536,203...4,561,066
Ensembl chr20:4,536,203...4,561,066 		JBrowse link
G Cfh complement factor H decreases phosphorylation ISO olanzapine results in decreased phosphorylation of CFH protein CTD PMID:25821032 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 affects binding ISO olanzapine binds to CHRM1 protein CTD PMID:16983399 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205 		JBrowse link
G Clu clusterin affects phosphorylation ISO olanzapine affects the phosphorylation of CLU protein CTD PMID:25821032 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases phosphorylation ISO olanzapine results in decreased phosphorylation of COL1A1 protein CTD PMID:25821032 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP olanzapine results in increased expression of COMT mRNA CTD PMID:15964593 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622 		JBrowse link
G Cp ceruloplasmin affects phosphorylation ISO olanzapine affects the phosphorylation of CP protein CTD PMID:25821032 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions EXP [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of CPT2 mRNA; [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA CTD PMID:23226405 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP [Fluoxetine co-treated with olanzapine] results in decreased phosphorylation of CREB1 protein CTD PMID:14556240 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
increases expression
multiple interactions		 ISO olanzapine results in decreased expression of CTNNB1 mRNA
Olanzapine results in increased expression of CTNNB1 mRNA
Olanzapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]		 CTD PMID:18797397, PMID:31563592 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
multiple interactions		 ISO CYP1A2 protein affects the metabolism of olanzapine
Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of olanzapine]		 CTD PMID:15545309, PMID:15883149 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Dab1 DAB adaptor protein 1 decreases expression EXP olanzapine results in decreased expression of DAB1 protein CTD PMID:19359144 NCBI chr 5:123,154,360...124,279,170
Ensembl chr 5:123,905,166...124,280,115 		JBrowse link
G Dclk1 doublecortin-like kinase 1 increases expression ISO olanzapine results in increased expression of DCLK1 mRNA CTD PMID:18797397 NCBI chr 2:144,646,255...144,939,389
Ensembl chr 2:144,646,308...144,936,927 		JBrowse link
G Drd1 dopamine receptor D1 affects binding ISO olanzapine binds to DRD1 protein CTD PMID:24389121 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541 		JBrowse link
G Drd2 dopamine receptor D2 increases response to substance
affects binding
multiple interactions
decreases activity
affects activity		 ISO
EXP		 DRD2 gene SNP results in increased susceptibility to olanzapine; DRD2 intron SNP results in increased susceptibility to olanzapine
olanzapine binds to DRD2 protein
olanzapine promotes the reaction [Dopamine binds to DRD2 protein]
olanzapine results in decreased activity of DRD2 protein
olanzapine affects the activity of DRD2 protein		 CTD PMID:10482380, PMID:10831489, PMID:11198054, PMID:15716360, PMID:20361897, PMID:20375926, PMID:21187413, PMID:24389121 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO DRD3 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine] CTD PMID:20021991 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327 		JBrowse link
G F2 coagulation factor II affects phosphorylation ISO olanzapine affects the phosphorylation of F2 protein CTD PMID:25821032 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Olanzapine results in increased expression of FABP1 mRNA CTD PMID:31437515 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954 		JBrowse link
G Fasn fatty acid synthase increases expression ISO olanzapine results in increased expression of FASN mRNA CTD PMID:17651982 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP [Fluoxetine co-treated with olanzapine] results in increased expression of FGF2 mRNA CTD PMID:15158429 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Fn1 fibronectin 1 affects phosphorylation ISO olanzapine affects the phosphorylation of FN1 protein CTD PMID:25821032 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Fluoxetine co-treated with olanzapine] results in decreased expression of FOS protein CTD PMID:14556240 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions EXP olanzapine inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOSL1 protein] CTD PMID:11425506 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066 		JBrowse link
G Gad1 glutamate decarboxylase 1 decreases expression EXP olanzapine results in decreased expression of GAD1 mRNA; olanzapine results in decreased expression of GAD1 protein CTD PMID:14519413, PMID:19359144 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157 		JBrowse link
G Gad2 glutamate decarboxylase 2 decreases expression EXP olanzapine results in decreased expression of GAD2 protein CTD PMID:19359144 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040 		JBrowse link
G Gc GC, vitamin D binding protein affects phosphorylation ISO olanzapine affects the phosphorylation of GC protein CTD PMID:25821032 NCBI chr14:20,267,023...20,302,577
Ensembl chr14:20,266,891...20,302,581 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression		 ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA] CTD PMID:32652086 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions
increases expression		 ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of GHRL protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of GHRL protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHRL protein] CTD PMID:32652086 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066 		JBrowse link
G Ghsr growth hormone secretagogue receptor increases expression
multiple interactions		 ISO Olanzapine results in increased expression of GHSR mRNA
capsazepine inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]		 CTD PMID:32652086 NCBI chr 2:113,065,953...113,071,265
Ensembl chr 2:113,066,885...113,070,261 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases expression EXP olanzapine results in increased expression of GRIA2 mRNA CTD PMID:11526992 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression EXP olanzapine results in increased expression of GRIA3 mRNA CTD PMID:11526992 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
decreases expression		 ISO olanzapine results in increased phosphorylation of GSK3B protein
Olanzapine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]
Olanzapine results in decreased expression of GSK3B mRNA		 CTD PMID:19440698, PMID:31563592 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression
decreases expression
multiple interactions		 ISO
EXP		 olanzapine results in increased expression of HMGCR mRNA
olanzapine results in decreased expression of HMGCR mRNA
1-(carboxymethylthio)tetradecane promotes the reaction [olanzapine results in decreased expression of HMGCR mRNA]; olanzapine promotes the reaction [1-(carboxymethylthio)tetradecane results in decreased expression of HMGCR mRNA]		 CTD PMID:17052361, PMID:23226405 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO olanzapine results in increased expression of HMGCS1 mRNA CTD PMID:17052361 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055 		JBrowse link
G Hpx hemopexin affects phosphorylation ISO olanzapine affects the phosphorylation of HPX protein CTD PMID:25821032 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073 		JBrowse link
G Hrg histidine-rich glycoprotein affects phosphorylation ISO olanzapine affects the phosphorylation of HRG protein CTD PMID:25821032 NCBI chr11:81,621,274...81,639,938
Ensembl chr11:81,621,283...81,639,952 		JBrowse link
G Hrh1 histamine receptor H 1 affects binding
multiple interactions		 ISO olanzapine binds to HRH1 protein
HRH1 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine]		 CTD PMID:16983399, PMID:20021991, PMID:24389121 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
affects binding
decreases activity		 ISO
EXP		 olanzapine binds to and results in decreased activity of HTR2A protein
olanzapine binds to HTR2A protein
olanzapine results in decreased activity of HTR2A protein
[[olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in decreased activity of HTR2A protein]; [olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; olanzapine binds to and results in decreased activity of HTR2A protein		 CTD PMID:16983399, PMID:18976543, PMID:19304867, PMID:20521326, PMID:24389121 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C increases response to substance
affects binding
affects response to substance		 ISO HTR2C gene polymorphism results in increased susceptibility to olanzapine
olanzapine binds to HTR2C protein
HTR2C gene polymorphism affects the susceptibility to Olanzapine; HTR2C gene SNP affects the susceptibility to Olanzapine; HTR2C protein affects the susceptibility to Olanzapine		 CTD PMID:15666332, PMID:16983399, PMID:19142110, PMID:19434072, PMID:24389121 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039 		JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 affects binding ISO olanzapine binds to HTR6 protein CTD PMID:16983399 NCBI chr 5:157,501,202...157,518,870
Ensembl chr 5:157,503,040...157,518,631 		JBrowse link
G Il10 interleukin 10 increases expression
decreases expression
multiple interactions		 ISO Olanzapine results in increased expression of IL10 mRNA
Olanzapine results in decreased expression of IL10 protein
Lithium inhibits the reaction [Olanzapine results in decreased expression of IL10 protein]		 CTD PMID:30695037 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO Lithium inhibits the reaction [Olanzapine results in increased expression of IL1B mRNA]; Lithium inhibits the reaction [Olanzapine results in increased expression of IL1B protein]
Olanzapine results in increased expression of IL1B mRNA; Olanzapine results in increased expression of IL1B protein		 CTD PMID:30695037 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of IL6 protein]; Lithium inhibits the reaction [Olanzapine results in increased expression of IL6 mRNA]; Lithium inhibits the reaction [Olanzapine results in increased expression of IL6 protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of IL6 protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of IL6 protein]
Olanzapine results in increased expression of IL6 mRNA; Olanzapine results in increased expression of IL6 protein		 CTD PMID:30695037, PMID:32652086 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Ins2 insulin 2 increases secretion
increases expression		 ISO olanzapine results in increased secretion of INS protein
olanzapine results in increased expression of INS protein		 CTD PMID:11769361, PMID:11927762, PMID:16601995, PMID:19512971 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 affects phosphorylation ISO olanzapine affects the phosphorylation of ITIH2 protein CTD PMID:25821032 NCBI chr17:72,160,734...72,197,248
Ensembl chr17:72,160,735...72,195,509 		JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 affects phosphorylation ISO olanzapine affects the phosphorylation of ITIH4 protein CTD PMID:25821032 NCBI chr16:6,970,367...6,985,538
Ensembl chr16:6,970,342...6,985,579 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions
increases activity		 EXP [[olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in decreased activity of HTR2A protein]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in increased expression of RGS7 mRNA]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in increased expression of RGS7 protein]; [olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein
olanzapine results in increased activity of JAK2 protein		 CTD PMID:18976543, PMID:19304867 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509 		JBrowse link
G Kcna1 potassium voltage-gated channel subfamily A member 1 increases expression ISO olanzapine results in increased expression of KCNA1 mRNA CTD PMID:18797397 NCBI chr 4:159,190,781...159,192,526
Ensembl chr 4:159,190,804...159,192,526 		JBrowse link
G Kcnab1 potassium voltage-gated channel subfamily A member regulatory beta subunit 1 decreases expression ISO olanzapine results in decreased expression of KCNAB1 mRNA CTD PMID:18797397 NCBI chr 2:155,555,798...156,011,438
Ensembl chr 2:155,718,359...156,009,526 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions		 ISO olanzapine results in decreased activity of KCNH2 protein
olanzapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]		 CTD PMID:16494862, PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 decreases expression ISO olanzapine results in decreased expression of KCNIP3 mRNA; olanzapine results in decreased expression of KCNIP3 protein CTD PMID:18797397 NCBI chr 3:120,023,062...120,087,650
Ensembl chr 3:120,023,917...120,087,136 		JBrowse link
G Klc1 kinesin light chain 1 decreases expression ISO olanzapine results in decreased expression of KLC1 mRNA CTD PMID:18797397 NCBI chr 6:136,330,151...136,373,716
Ensembl chr 6:136,330,383...136,373,721 		JBrowse link
G Kng2 kininogen 2 affects phosphorylation ISO olanzapine affects the phosphorylation of KNG1 protein CTD PMID:25821032 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Ldlr low density lipoprotein receptor increases expression
multiple interactions		 ISO olanzapine results in increased expression of LDLR mRNA
olanzapine promotes the reaction [SREBF1 protein results in increased expression of LDLR mRNA]		 CTD PMID:17052361, PMID:17651982 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Lep leptin increases expression
multiple interactions		 ISO olanzapine results in increased expression of LEP protein
Olanzapine results in increased expression of LEP protein
capsazepine inhibits the reaction [Olanzapine results in increased expression of LEP protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of LEP protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of LEP protein]		 CTD PMID:11927762, PMID:19512971, PMID:32652086 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Mal mal, T-cell differentiation protein decreases expression ISO olanzapine results in decreased expression of MAL mRNA CTD PMID:18797397 NCBI chr 3:120,209,647...120,233,655
Ensembl chr 3:120,209,647...120,233,655 		JBrowse link
G Maoa monoamine oxidase A increases expression EXP olanzapine results in increased expression of MAOA mRNA CTD PMID:15964593 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
G Maob monoamine oxidase B increases expression EXP olanzapine results in increased expression of MAOB mRNA CTD PMID:15964593 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534 		JBrowse link
G Map2 microtubule-associated protein 2 increases expression EXP olanzapine results in increased expression of MAP2 mRNA CTD PMID:15079866 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR gene polymorphism affects the susceptibility to olanzapine; MTHFR protein affects the susceptibility to olanzapine CTD PMID:20547447 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910 		JBrowse link
G Ncan neurocan decreases expression ISO olanzapine results in decreased expression of NCAN mRNA CTD PMID:18797397 NCBI chr16:21,050,243...21,076,707
Ensembl chr16:21,050,243...21,076,707 		JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase decreases expression ISO olanzapine results in decreased expression of NEDD4 mRNA; olanzapine results in decreased expression of NEDD4 protein CTD PMID:18797397 NCBI chr 8:79,323,408...79,408,842
Ensembl chr 8:79,323,408...79,408,833 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression		 ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of NFKB1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NFKB1 mRNA] CTD PMID:32652086 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nptn neuroplastin increases expression ISO olanzapine results in increased expression of NPTN mRNA CTD PMID:18797397 NCBI chr 8:63,379,062...63,445,694
Ensembl chr 8:63,379,087...63,445,686 		JBrowse link
G Npy neuropeptide Y decreases expression
increases expression
multiple interactions		 EXP
ISO		 olanzapine results in decreased expression of NPY mRNA
Olanzapine results in increased expression of NPY mRNA
capsazepine inhibits the reaction [Olanzapine results in increased expression of NPY mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of NPY mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NPY mRNA]
olanzapine results in increased expression of NPY protein		 CTD PMID:16516965, PMID:21695181, PMID:32652086 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097 		JBrowse link
G Numbl NUMB-like, endocytic adaptor protein decreases expression ISO olanzapine results in decreased expression of NUMBL mRNA CTD PMID:18797397 NCBI chr 1:84,067,841...84,091,659
Ensembl chr 1:84,067,938...84,091,671 		JBrowse link
G Pde1a phosphodiesterase 1A increases expression EXP olanzapine results in increased expression of PDE1A mRNA CTD PMID:20222156 NCBI chr 3:66,803,247...67,263,658
Ensembl chr 3:66,803,247...66,885,094 		JBrowse link
G Pde8b phosphodiesterase 8B increases expression EXP olanzapine results in increased expression of PDE8B mRNA CTD PMID:20222156 NCBI chr 2:24,718,548...24,955,533
Ensembl chr 2:24,719,976...24,923,128 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions
decreases expression		 ISO capsazepine inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA] CTD PMID:32652086 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867 		JBrowse link
G Plac8 placenta associated 8 affects phosphorylation ISO olanzapine affects the phosphorylation of C15 protein CTD PMID:25821032 NCBI chr14:10,692,799...10,714,556
Ensembl chr14:10,692,764...10,714,524 		JBrowse link
G Plp1 proteolipid protein 1 decreases expression ISO olanzapine results in decreased expression of PLP1 mRNA CTD PMID:18797397 NCBI chr  X:107,494,326...107,511,355
Ensembl chr  X:107,496,072...107,511,348 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 affects expression EXP olanzapine affects the expression of PNPLA2 mRNA CTD PMID:23226405 NCBI chr 1:214,434,638...214,439,720
Ensembl chr 1:214,434,626...214,439,720 		JBrowse link
G Pomc proopiomelanocortin decreases expression
multiple interactions		 EXP
ISO		 olanzapine results in decreased expression of POMC protein
Olanzapine results in decreased expression of POMC mRNA
capsazepine inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA]		 CTD PMID:21695181, PMID:32652086 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO olanzapine results in increased expression of PPARG protein alternative form CTD PMID:17651982 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions		 EXP olanzapine results in decreased expression of PPARGC1A mRNA
[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of PPARGC1A mRNA; olanzapine promotes the reaction [1-(carboxymethylthio)tetradecane results in decreased expression of PPARGC1A mRNA]		 CTD PMID:23226405 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 increases expression
multiple interactions		 ISO Olanzapine results in increased expression of PRKAG2 mRNA
capsazepine inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA]		 CTD PMID:32652086 NCBI chr 4:6,559,153...6,799,888
Ensembl chr 4:6,559,545...6,799,632 		JBrowse link
G Prl prolactin multiple interactions
increases secretion
increases expression		 ISO [olanzapine co-treated with Fluoxetine] results in increased expression of PRL protein
olanzapine results in increased secretion of PRL protein
olanzapine results in increased expression of PRL protein		 CTD PMID:9090331, PMID:9265911, PMID:9376336, PMID:10831029, PMID:11048906, PMID:11442886, PMID:12447030, PMID:15286066, PMID:15960571, PMID:18063941, PMID:19896213 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Prrc2a proline-rich coiled-coil 2A decreases expression ISO olanzapine results in decreased expression of PRRC2A mRNA CTD PMID:18797397 NCBI chr20:5,139,881...5,155,371
Ensembl chr20:5,139,882...5,155,293 		JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO olanzapine results in decreased expression of RAPGEF4 mRNA CTD PMID:18797397 NCBI chr 3:58,632,338...58,925,127
Ensembl chr 3:58,632,476...58,924,038 		JBrowse link
G Reln reelin increases expression EXP olanzapine results in increased expression of RELN mRNA; olanzapine results in increased expression of RELN protein CTD PMID:19359144 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670 		JBrowse link
G Rgs7 regulator of G-protein signaling 7 multiple interactions
increases expression		 EXP [[Olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [Olanzapine results in increased expression of RGS7 mRNA]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [Olanzapine results in increased expression of RGS7 protein]; Olanzapine promotes the reaction [[STAT3 protein binds to RGS7 promoter] which results in increased expression of RGS7 mRNA]; Olanzapine promotes the reaction [STAT3 protein binds to RGS7 promoter]
olanzapine results in increased expression of RGS7 mRNA; olanzapine results in increased expression of RGS7 protein		 CTD PMID:18976543, PMID:19304867 NCBI chr13:93,095,659...93,534,452
Ensembl chr13:93,095,200...93,307,199 		JBrowse link
G Rtn4 reticulon 4 decreases expression ISO olanzapine results in decreased expression of RTN4 mRNA CTD PMID:18797397 NCBI chr14:114,126,931...114,174,459
Ensembl chr14:114,126,943...114,174,458 		JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression ISO olanzapine results in decreased expression of S100A9 mRNA CTD PMID:18797397 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276 		JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO olanzapine results in increased expression of SC5D mRNA CTD PMID:17052361 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050 		JBrowse link
G Serpina3m serpin family A member 3M increases phosphorylation ISO olanzapine results in increased phosphorylation of SERPINA3 protein CTD PMID:25821032 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055 		JBrowse link
G Serping1 serpin family G member 1 affects phosphorylation ISO olanzapine affects the phosphorylation of SERPING1 protein CTD PMID:25821032 NCBI chr 3:72,161,230...72,171,109
Ensembl chr 3:72,161,189...72,171,078 		JBrowse link
G Serpini1 serpin family I member 1 decreases expression ISO olanzapine results in decreased expression of SERPINI1 mRNA CTD PMID:18797397 NCBI chr 2:174,013,058...174,111,693
Ensembl chr 2:174,013,288...174,111,752 		JBrowse link
G Shbg sex hormone binding globulin decreases expression ISO olanzapine results in decreased expression of SHBG protein CTD PMID:19512971 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO olanzapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 decreases expression
multiple interactions		 ISO Olanzapine results in decreased expression of SLC22A5 mRNA; Olanzapine results in decreased expression of SLC22A5 protein
Olanzapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine analog]		 CTD PMID:31437515 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853 		JBrowse link
G Slc27a2 solute carrier family 27 member 2 increases expression ISO Olanzapine results in increased expression of SLC27A2 mRNA CTD PMID:31437515 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531 		JBrowse link
G Slc27a5 solute carrier family 27 member 5 increases expression ISO Olanzapine results in increased expression of SLC27A5 mRNA CTD PMID:31437515 NCBI chr 1:65,576,599...65,587,192
Ensembl chr 1:65,576,535...65,587,186 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO olanzapine results in increased expression of SLC2A4 mRNA CTD PMID:16002093 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487 		JBrowse link
G Snap25 synaptosome associated protein 25 affects response to substance ISO SNAP25 gene SNP affects the susceptibility to olanzapine CTD PMID:15823421 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression		 EXP olanzapine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; olanzapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]; olanzapine inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD1 mRNA]
olanzapine results in increased expression of SOD1 mRNA		 CTD PMID:12752374, PMID:12868070, PMID:16564057 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression		 ISO olanzapine promotes the reaction [SREBF1 protein results in increased expression of LDLR mRNA]; olanzapine results in increased activity of and results in increased expression of SREBF1 protein
olanzapine results in increased expression of SREBF1 mRNA		 CTD PMID:17651982 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO
EXP		 olanzapine results in increased cleavage of and results in increased activity of SREBF2 protein
[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of SREBF2 mRNA		 CTD PMID:17052361, PMID:23226405 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP olanzapine promotes the reaction [[STAT3 protein binds to RGS7 promoter] which results in increased expression of RGS7 mRNA]; olanzapine promotes the reaction [STAT3 protein binds to RGS7 promoter] CTD PMID:18976543 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Sypl1 synaptophysin-like 1 decreases expression ISO olanzapine results in decreased expression of SYPL mRNA CTD PMID:18797397 NCBI chr 6:52,265,920...52,286,037
Ensembl chr 6:52,265,930...52,285,029 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP olanzapine inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:15276877 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of TNF protein]; Lithium inhibits the reaction [Olanzapine results in increased expression of TNF mRNA]; Lithium inhibits the reaction [Olanzapine results in increased expression of TNF protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of TNF protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TNF protein]
Olanzapine results in increased expression of TNF mRNA; Olanzapine results in increased expression of TNF protein		 CTD PMID:30695037, PMID:32652086 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO olanzapine results in increased expression of TP53 mRNA CTD PMID:16160616 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases expression		 ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of TRPV1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV1 mRNA] CTD PMID:32652086 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 multiple interactions
increases expression		 ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV3 mRNA] CTD PMID:32652086 NCBI chr10:59,829,755...59,863,780
Ensembl chr10:59,831,241...59,860,987 		JBrowse link
G Ttr transthyretin increases expression EXP olanzapine results in increased expression of TTR mRNA CTD PMID:15927202 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177 		JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions EXP [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of UCP1 mRNA CTD PMID:23226405 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807 		JBrowse link
G Vipr2 vasoactive intestinal peptide receptor 2 affects expression ISO olanzapine affects the expression of VIPR2 mRNA CTD PMID:27900577 NCBI chr 6:143,932,960...144,009,476
Ensembl chr 6:143,938,040...144,008,072 		JBrowse link
G Vldlr very low density lipoprotein receptor increases expression EXP olanzapine results in increased expression of VLDLR protein CTD PMID:19359144 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205 		JBrowse link
perazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases oxidation ISO FMO3 protein results in increased oxidation of Perazine CTD PMID:11026737 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963 		JBrowse link
ponatinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions
decreases phosphorylation
decreases activity		 ISO ponatinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of ABL1 protein mutant form]; ponatinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of CRKL protein]; ponatinib inhibits the reaction [ABL1 protein results in increased phosphorylation of ABL1 protein]
ponatinib results in decreased phosphorylation of ABL1 protein; ponatinib results in decreased phosphorylation of ABL1 protein mutant form
ponatinib analog results in decreased activity of ABL1 protein; ponatinib analog results in decreased activity of ABL1 protein mutant form; ponatinib results in decreased activity of ABL1 protein; ponatinib results in decreased activity of ABL1 protein mutant form		 CTD PMID:19878872, PMID:20513156, PMID:21561767, PMID:22781593, PMID:25304212 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388 		JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase decreases activity ISO ponatinib results in decreased activity of ABL2 protein CTD PMID:19878872 NCBI chr13:74,154,533...74,333,244
Ensembl chr13:74,154,835...74,333,244 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased phosphorylation of AKT1 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of AKT1 protein] CTD PMID:25053825, PMID:25304212 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of BCL2 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of BCL2 protein] CTD PMID:25053825 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression		 ISO (+)-JQ1 compound promotes the reaction [ponatinib results in increased expression of BCL2L11 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in increased expression of BCL2L11 protein] CTD PMID:25053825 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Bcr BCR activator of RhoGEF and GTPase decreases phosphorylation ISO ponatinib results in decreased phosphorylation of BCR protein mutant form CTD PMID:19878872 NCBI chr20:14,421,250...14,546,406
Ensembl chr20:14,421,141...14,545,772 		JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of BLK protein CTD PMID:19878872 NCBI chr15:46,555,552...46,593,778
Ensembl chr15:46,555,188...46,593,653 		JBrowse link
G Bmx BMX non-receptor tyrosine kinase decreases activity ISO ponatinib results in decreased activity of BMX protein CTD PMID:19878872 NCBI chr  X:31,976,231...32,046,326
Ensembl chr  X:31,984,612...32,045,448 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases activity ISO ponatinib analog results in decreased activity of BRAF protein; ponatinib analog results in decreased activity of BRAF protein mutant form CTD PMID:21561767 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO ponatinib results in increased cleavage of CASP3 protein CTD PMID:29341879 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression		 ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of CDK4 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK4 protein] CTD PMID:25053825 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
decreases expression		 ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of CDK6 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK6 protein] CTD PMID:25053825 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO (+)-JQ1 compound promotes the reaction [ponatinib results in increased expression of CDKN1A protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in increased expression of CDKN1A protein] CTD PMID:25053825 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein multiple interactions
decreases phosphorylation		 ISO ponatinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of CRKL protein]
ponatinib results in decreased phosphorylation of CRKL protein		 CTD PMID:19878872, PMID:25304212 NCBI chr11:87,338,606...87,356,644
Ensembl chr11:87,778,312...87,815,043 		JBrowse link
G Csf1r colony stimulating factor 1 receptor decreases activity ISO ponatinib analog results in decreased activity of CSF1R protein; ponatinib results in decreased activity of CSF1R protein CTD PMID:19878872, PMID:21561767 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300 		JBrowse link
G Csk C-terminal Src kinase decreases activity ISO ponatinib results in decreased activity of CSK protein CTD PMID:19878872 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 decreases activity ISO ponatinib results in decreased activity of DDR2 protein CTD PMID:19878872 NCBI chr13:88,311,639...88,436,561
Ensembl chr13:88,317,145...88,436,789 		JBrowse link
G Egfr epidermal growth factor receptor decreases activity ISO ponatinib results in decreased activity of EGFR protein mutant form CTD PMID:19878872 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Epha1 Eph receptor A1 decreases activity ISO ponatinib results in decreased activity of EPHA1 protein CTD PMID:19878872 NCBI chr 4:71,749,100...71,763,681
Ensembl chr 4:71,749,242...71,763,679 		JBrowse link
G Epha2 Eph receptor A2 decreases activity ISO ponatinib analog results in decreased activity of EPHA2 protein; ponatinib results in decreased activity of EPHA2 protein CTD PMID:19878872, PMID:21561767 NCBI chr 5:159,845,773...159,874,203
Ensembl chr 5:159,845,774...159,874,206 		JBrowse link
G Epha3 Eph receptor A3 decreases activity ISO ponatinib analog results in decreased activity of EPHA3 protein; ponatinib results in decreased activity of EPHA3 protein CTD PMID:19878872, PMID:21561767 NCBI chr11:421,253...783,037
Ensembl chr11:421,135...782,954 		JBrowse link
G Epha4 Eph receptor A4 decreases activity ISO ponatinib results in decreased activity of EPHA4 protein CTD PMID:19878872 NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458 		JBrowse link
G Epha5 EPH receptor A5 decreases activity ISO ponatinib results in decreased activity of EPHA5 protein CTD PMID:19878872 NCBI chr14:25,589,312...25,958,258
Ensembl chr14:25,589,762...25,958,227 		JBrowse link
G Epha7 Eph receptor A7 decreases activity ISO ponatinib analog results in decreased activity of EPHA7 protein; ponatinib results in decreased activity of EPHA7 protein CTD PMID:19878872, PMID:21561767 NCBI chr 5:43,602,744...43,761,198
Ensembl chr 5:43,603,043...43,757,549 		JBrowse link
G Epha8 Eph receptor A8 decreases activity ISO ponatinib results in decreased activity of EPHA8 protein CTD PMID:19878872 NCBI chr 5:155,293,731...155,321,016
Ensembl chr 5:155,295,314...155,316,495 		JBrowse link
G Ephb1 Eph receptor B1 decreases activity ISO ponatinib results in decreased activity of EPHB1 protein CTD PMID:19878872 NCBI chr 8:110,376,954...110,813,193
Ensembl chr 8:110,376,954...110,813,000 		JBrowse link
G Ephb2 Eph receptor B2 decreases activity ISO ponatinib results in decreased activity of EPHB2 protein CTD PMID:19878872 NCBI chr 5:155,024,478...155,143,539
Ensembl chr 5:155,022,493...155,204,456 		JBrowse link
G Ephb3 Eph receptor B3 decreases activity ISO ponatinib results in decreased activity of EPHB3 protein CTD PMID:19878872 NCBI chr11:83,527,960...83,546,742
Ensembl chr11:83,527,962...83,546,674 		JBrowse link
G Ephb4 EPH receptor B4 decreases activity ISO ponatinib results in decreased activity of EPHB4 protein CTD PMID:19878872 NCBI chr12:22,393,338...22,418,332
Ensembl chr12:22,393,330...22,417,980 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases activity ISO ponatinib results in decreased activity of ERBB4 protein CTD PMID:19878872 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases activity
decreases phosphorylation		 ISO ponatinib analog results in decreased activity of FGFR1 protein; ponatinib results in decreased activity of FGFR1 protein; ponatinib results in decreased activity of FGFR1 protein mutant form
ponatinib results in decreased phosphorylation of FGFR1 protein mutant form		 CTD PMID:19878872, PMID:21482694, PMID:21561767, PMID:22875613 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases activity ISO ponatinib analog results in decreased activity of FGFR2 protein; ponatinib results in decreased activity of FGFR2 protein; ponatinib results in decreased activity of FGFR2 protein mutant form CTD PMID:19878872, PMID:21561767 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases activity ISO ponatinib analog results in decreased activity of FGFR3 protein; ponatinib results in decreased activity of FGFR3 protein CTD PMID:19878872, PMID:21561767 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 decreases activity ISO ponatinib analog results in decreased activity of FGFR4 protein; ponatinib results in decreased activity of FGFR4 protein CTD PMID:19878872, PMID:21561767 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321 		JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of FGR protein CTD PMID:19878872 NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases activity ISO ponatinib analog results in decreased activity of FLT1 protein; ponatinib results in decreased activity of FLT1 protein CTD PMID:19878872, PMID:21561767 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases activity
decreases phosphorylation
multiple interactions		 ISO ponatinib analog results in decreased activity of FLT3 protein; ponatinib results in decreased activity of FLT3 protein; ponatinib results in decreased activity of FLT3 protein mutant form
ponatinib results in decreased phosphorylation of FLT3 protein mutant form
ponatinib inhibits the reaction [FLT3 protein mutant form results in increased phosphorylation of FLT3 protein mutant form]		 CTD PMID:19878872, PMID:21482694, PMID:21561767, PMID:22409268 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570 		JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 decreases activity ISO ponatinib analog results in decreased activity of FLT4 protein; ponatinib results in decreased activity of FLT4 protein CTD PMID:19878872, PMID:21561767 NCBI chr10:35,078,782...35,120,296
Ensembl chr10:35,078,726...35,121,599 		JBrowse link
G Frk fyn-related Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of FRK protein CTD PMID:19878872 NCBI chr20:41,266,408...41,383,731
Ensembl chr20:41,266,566...41,383,424 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of FYN protein CTD PMID:19878872 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO ponatinib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of HCK protein CTD PMID:19878872 NCBI chr 3:148,579,917...148,623,026
Ensembl chr 3:148,579,920...148,623,033 		JBrowse link
G Jak1 Janus kinase 1 decreases activity ISO ponatinib results in decreased activity of JAK1 protein CTD PMID:19878872 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904 		JBrowse link
G Jak2 Janus kinase 2 decreases activity ISO ponatinib results in decreased activity of JAK2 protein CTD PMID:19878872 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509 		JBrowse link
G Jak3 Janus kinase 3 decreases activity ISO ponatinib results in decreased activity of JAK3 protein CTD PMID:19878872 NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668 		JBrowse link
G Kdr kinase insert domain receptor decreases activity ISO ponatinib analog results in decreased activity of KDR protein; ponatinib results in decreased activity of KDR protein CTD PMID:19878872, PMID:21561767 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases activity
decreases phosphorylation		 ISO ponatinib results in decreased activity of KIT protein; ponatinib results in decreased activity of KIT protein mutant form
ponatinib results in decreased phosphorylation of KIT protein mutant form		 CTD PMID:19878872, PMID:21482694 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of LCK protein CTD PMID:19878872 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983 		JBrowse link
G Lmna lamin A/C increases cleavage ISO ponatinib results in increased cleavage of LMNA protein CTD PMID:22875613 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of LYN protein CTD PMID:19878872 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases lipidation ISO ponatinib results in increased lipidation of MAP1LC3A protein CTD PMID:29341879 NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased phosphorylation of MAPK1 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of MAPK1 protein] CTD PMID:22409268, PMID:22875613, PMID:25053825, PMID:25304212 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased phosphorylation of MAPK3 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of MAPK3 protein] CTD PMID:22409268, PMID:22875613, PMID:25053825, PMID:25304212 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO ponatinib results in decreased expression of MCL1 protein CTD PMID:22409268 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression		 ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of MYC protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of MYC protein] CTD PMID:25053825 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 decreases activity ISO ponatinib results in decreased activity of NTRK1 protein CTD PMID:19878872 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 decreases activity ISO ponatinib results in decreased activity of NTRK2 protein CTD PMID:19878872 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 decreases activity ISO ponatinib results in decreased activity of NTRK3 protein CTD PMID:19878872 NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO (+)-JQ1 compound promotes the reaction [ponatinib results in increased cleavage of PARP1 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in increased cleavage of PARP1 protein] CTD PMID:21482694, PMID:22875613, PMID:25053825 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha decreases activity
decreases phosphorylation		 ISO ponatinib analog results in decreased activity of PDGFRA protein; ponatinib results in decreased activity of PDGFRA protein; ponatinib results in decreased activity of PDGFRA protein mutant form
ponatinib results in decreased phosphorylation of PDGFRA protein mutant form		 CTD PMID:19878872, PMID:21482694, PMID:21561767 NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases activity ISO ponatinib analog results in decreased activity of PDGFRB protein; ponatinib results in decreased activity of PDGFRB protein CTD PMID:19878872, PMID:21561767 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta decreases activity ISO ponatinib results in decreased activity of PTK2B protein CTD PMID:19878872 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656 		JBrowse link
G Ptk6 protein tyrosine kinase 6 decreases activity ISO ponatinib results in decreased activity of PTK6 protein CTD PMID:19878872 NCBI chr 3:176,698,305...176,706,896
Ensembl chr 3:176,698,305...176,706,896 		JBrowse link
G Ret ret proto-oncogene decreases activity ISO ponatinib analog results in decreased activity of RET protein; ponatinib results in decreased activity of RET protein; ponatinib results in decreased activity of RET protein mutant form CTD PMID:19878872, PMID:21561767 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases activity ISO ponatinib analog results in decreased activity of SRC protein; ponatinib results in decreased activity of SRC protein CTD PMID:19878872, PMID:21561767 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions
decreases phosphorylation		 ISO ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5A protein]
ponatinib results in decreased phosphorylation of STAT5A protein		 CTD PMID:22875613, PMID:25053825 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions ISO ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5B protein] CTD PMID:25053825 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829 		JBrowse link
G Tek TEK receptor tyrosine kinase decreases activity ISO ponatinib analog results in decreased activity of TEK protein; ponatinib results in decreased activity of TEK protein CTD PMID:19878872, PMID:21561767 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799 		JBrowse link
G Tnni3 troponin I3, cardiac type increases secretion ISO ponatinib results in increased secretion of TNNI3 protein CTD PMID:25304212 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488 		JBrowse link
G Tyk2 tyrosine kinase 2 decreases activity ISO ponatinib results in decreased activity of TYK2 protein CTD PMID:19878872 NCBI chr 8:22,118,224...22,149,807
Ensembl chr 8:22,124,560...22,150,005 		JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of YES1 protein CTD PMID:19878872 NCBI chr 9:121,802,471...121,918,906
Ensembl chr 9:121,802,673...121,902,678 		JBrowse link
prochlorperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases activity ISO Prochlorperazine results in increased activity of ACHE protein CTD PMID:29614332 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Prochlorperazine binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Tfeb transcription factor EB affects localization ISO Prochlorperazine affects the localization of TFEB protein CTD PMID:28366621 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596 		JBrowse link
rifampicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadac arylacetamide deacetylase multiple interactions
increases hydrolysis
decreases acetylation		 ISO AADAC mRNA affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; bis(4-nitrophenyl)phosphate inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Isoflurophate inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Phenylmethylsulfonyl Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Sodium Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]
AADAC protein results in increased hydrolysis of Rifampin		 CTD PMID:21856291, PMID:22207054 NCBI chr 2:150,146,234...150,157,480
Ensembl chr 2:150,146,234...150,157,480 		JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 decreases expression
increases expression		 ISO Rifampin results in decreased expression of ABCA1 mRNA; Rifampin results in decreased expression of ABCA1 protein
Rifampin results in increased expression of ABCA1 mRNA; Rifampin results in increased expression of ABCA1 protein		 CTD PMID:15883047, PMID:17088262 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abca2 ATP binding cassette subfamily A member 2 increases expression ISO Rifampin results in increased expression of ABCA2 mRNA CTD PMID:27199754 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809 		JBrowse link
G Abca8 ATP binding cassette subfamily A member 8 decreases expression ISO Rifampin results in decreased expression of ABCA8 mRNA CTD PMID:27199754 NCBI chr10:98,236,919...98,308,288
Ensembl chr10:98,237,141...98,294,522 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
decreases activity
multiple interactions		 ISO
EXP		 Rifampin results in decreased expression of ABCB11 mRNA
Rifampin results in decreased activity of ABCB11 protein
Rifampin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:12135489, PMID:16837569, PMID:20829430, PMID:24014644, PMID:28437613 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
decreases activity
affects activity		 ISO
EXP		 [NR1I2 protein results in increased susceptibility to Rifampin] which results in increased expression of ABCB1 mRNA; [NR1I2 protein results in increased susceptibility to Rifampin] which results in increased expression of ABCB1 protein; [Rifampin binds to and results in increased activity of NR1I2 protein] promotes the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 protein; Camptothecin inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 protein]; mulberroside A inhibits the reaction [[NR1I2 protein results in increased susceptibility to Rifampin] which results in increased expression of ABCB1 mRNA]; mulberroside A inhibits the reaction [[NR1I2 protein results in increased susceptibility to Rifampin] which results in increased expression of ABCB1 protein]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]; pimecrolimus inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; resveratrol inhibits the reaction [Rifampin results in increased expression of ABCB1 protein]; Rifampin promotes the reaction [ABCB1 protein results in increased transport of Digoxin]
Rifampin results in increased expression of ABCB1 mRNA; Rifampin results in increased expression of ABCB1 protein
[Rifampin metabolite results in decreased activity of ABCB1A protein] which results in decreased abundance of Adenosine Triphosphate
Rifampin affects the activity of ABCB1 protein		 CTD PMID:8632764, PMID:11744607, PMID:14722322, PMID:15276086, PMID:15290871, PMID:15710169, PMID:15964336, PMID:16819505, PMID:16837569, PMID:16842400, PMID:17003290, PMID:17191263, PMID:17365992, PMID:18094037, PMID:19148864, PMID:19647009, PMID:20018165, PMID:20041327, PMID:20624464, PMID:22258563, PMID:22914566, PMID:23685082, PMID:23707768, PMID:24259679, PMID:24552687, PMID:25313206, PMID:25542144, PMID:26301745, PMID:26394120, PMID:27199754, PMID:27871908, PMID:27918128, PMID:29356861, PMID:30071242, PMID:31233785, PMID:32092453 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO Rifampin results in increased expression of ABCB4 mRNA CTD PMID:27199754 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 increases expression ISO Rifampin results in increased expression of ABCB6 mRNA CTD PMID:27199754 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Rifampin results in increased expression of ABCC1 mRNA CTD PMID:17191263 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 increases expression ISO Rifampin results in increased expression of ABCC10 mRNA CTD PMID:27199754 NCBI chr 9:17,041,351...17,061,263
Ensembl chr 9:17,041,389...17,063,780 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
increases expression
multiple interactions		 ISO ABCC2 protein affects the export of Rifampin
Rifampin results in increased expression of ABCC2; Rifampin results in increased expression of ABCC2 mRNA; Rifampin results in increased expression of ABCC2 protein
[Rifampin co-treated with ABCC2 gene mutant form] results in increased expression of ABCC3 protein		 CTD PMID:11836020, PMID:12206135, PMID:15652233, PMID:16837569, PMID:16952291, PMID:20832446, PMID:25313206, PMID:27199754 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression
increases activity		 ISO [Rifampin co-treated with ABCC2 gene mutant form] results in increased expression of ABCC3 protein; [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; Rifampin inhibits the reaction [Decitabine results in increased expression of ABCC3 mRNA]
Rifampin results in increased expression of ABCC3 mRNA
Rifampin results in increased activity of ABCC3 protein		 CTD PMID:14570758, PMID:16837569, PMID:16952291, PMID:19041851, PMID:20832446, PMID:23137910, PMID:27199754 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 increases expression ISO Rifampin results in increased expression of ABCC5 mRNA CTD PMID:19041851 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 increases expression ISO Rifampin results in increased expression of ABCC6 mRNA CTD PMID:27199754 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243 		JBrowse link
G Abcf1 ATP binding cassette subfamily F member 1 increases expression ISO Rifampin results in increased expression of ABCF1 mRNA CTD PMID:27199754 NCBI chr20:3,309,914...3,322,828
Ensembl chr20:3,309,899...3,322,825 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO Rifampin results in increased expression of ABCG1 mRNA; Rifampin results in increased expression of ABCG1 protein CTD PMID:12040753, PMID:17088262 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Rifampin results in increased expression of ABCG2 mRNA CTD PMID:16837569, PMID:27199754 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression ISO Rifampin results in increased expression of ABCG8 mRNA CTD PMID:27199754 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708 		JBrowse link
G Abi3 ABI family, member 3 decreases expression ISO Rifampin results in decreased expression of ABI3 mRNA CTD PMID:24552687 NCBI chr10:83,644,086...83,655,182
Ensembl chr10:83,644,086...83,655,182 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression ISO Rifampin results in increased expression of ACACA mRNA CTD PMID:27806127 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Actr10 actin related protein 10 increases expression ISO Rifampin results in increased expression of ACTR10 mRNA CTD PMID:24552687 NCBI chr 6:93,385,457...93,411,605
Ensembl chr 6:93,385,457...93,411,576 		JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) increases expression ISO Rifampin results in increased expression of ADH1C mRNA CTD PMID:12040753 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857 		JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Rifampin results in decreased expression of ADORA2A mRNA CTD PMID:24552687 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873 		JBrowse link
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 decreases expression ISO Rifampin results in decreased expression of AGAP2 mRNA CTD PMID:24552687 NCBI chr 7:70,360,199...70,377,422
Ensembl chr 7:70,364,813...70,377,422 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression		 ISO [Rifampin co-treated with Benzo(a)pyrene] results in increased expression of AHR mRNA; [Rifampin co-treated with Monocrotophos] results in decreased expression of AHR mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of AHR protein; NR1I2 protein inhibits the reaction [[Rifampin co-treated with Benzo(a)pyrene] results in increased expression of AHR mRNA]
Rifampin results in increased expression of AHR mRNA; Rifampin results in increased expression of AHR protein		 CTD PMID:22733800, PMID:28428138 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression
multiple interactions		 ISO Rifampin results in increased expression of AKR1B10 mRNA
pazopanib inhibits the reaction [Rifampin results in increased expression of AKR1B10 mRNA]; pimecrolimus inhibits the reaction [Rifampin results in increased expression of AKR1B10 mRNA]		 CTD PMID:29356861 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 increases expression ISO Rifampin results in increased expression of ALAS1 mRNA CTD PMID:24259679, PMID:24552687 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177 		JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of ANGPTL4 mRNA CTD PMID:21127053 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079 		JBrowse link
G Ankrd65 ankyrin repeat domain 65 decreases expression ISO Rifampin results in decreased expression of ANKRD65 mRNA CTD PMID:24552687 NCBI chr 5:173,237,642...173,239,899
Ensembl chr 5:173,237,642...173,239,899 		JBrowse link
G Anks1b ankyrin repeat and sterile alpha motif domain containing 1B decreases expression ISO Rifampin results in decreased expression of ANKS1B mRNA CTD PMID:24552687 NCBI chr 7:30,507,135...31,684,604
Ensembl chr 7:30,699,476...31,681,182 		JBrowse link
G Anxa5 annexin A5 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA CTD PMID:21224054 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130