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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-methylpiperazine
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Accession:CHEBI:46920 term browser browse the term
Synonyms:related_synonym: N-methylpiperazines



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2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO bisbenzimide ethoxide trihydrochloride inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
ISO ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride
ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride
abamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
[zosuquidar trihydrochloride results in decreased activity of ABCB1 protein] which results in decreased export of bisbenzimide ethoxide trihydrochloride; abamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
CTD PMID:25865432 PMID:34896433 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
increases transport
ISO abamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride] CTD PMID:25865432 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases abundance
decreases export
decreases activity
multiple interactions
increases export
increases transport
ISO ABCG2 protein results in decreased abundance of bisbenzimide ethoxide trihydrochloride
ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride
bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCG2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased export of bisbenzimide ethoxide trihydrochloride; [bisphenol A results in decreased activity of ABCG2 protein] which results in decreased transport of bisbenzimide ethoxide trihydrochloride; [MLN 8237 affects the activity of ABCG2 protein] which affects the export of bisbenzimide ethoxide trihydrochloride; [MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride; Cimetidine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; danofloxacin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein promotes the reaction [ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride]; Methotrexate inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Porphyrins inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Tobacco Smoke Pollution inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; verlukast inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
CTD PMID:12869632 PMID:19239227 PMID:26850786 PMID:26907376 PMID:27450509 More... NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases export ISO KEAP1 protein results in decreased export of bisbenzimide ethoxide trihydrochloride CTD PMID:25841332 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride CTD PMID:19239227 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028
JBrowse link
adavosertib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk1 cyclin-dependent kinase 1 decreases phosphorylation ISO adavosertib results in decreased phosphorylation of CDK1 protein CTD PMID:25125259 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455
JBrowse link
G Tp53 tumor protein p53 increases response to substance ISO TP53 gene mutant form results in increased susceptibility to adavosertib
TRP53 gene mutant form results in increased susceptibility to adavosertib
CTD PMID:25125259 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase decreases phosphorylation ISO adavosertib results in decreased phosphorylation of WEE1 protein CTD PMID:25125259 NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:173,608,949...173,632,449
JBrowse link
bosutinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase decreases activity ISO bosutinib results in decreased activity of ABL1 protein CTD PMID:17114238 NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:35,377,391...35,480,846
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
decreases expression
ISO bosutinib results in decreased phosphorylation of AKT1 protein
bosutinib results in decreased expression of AKT1 protein
CTD PMID:17129604 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [bosutinib results in increased activity of CASP1 protein]; Acetylcysteine inhibits the reaction [bosutinib results in increased expression of CASP1 mRNA]; bosutinib results in increased activity of and results in increased cleavage of CASP1 protein; Imatinib Mesylate inhibits the reaction [bosutinib results in increased activity of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [bosutinib results in increased activity of and results in increased cleavage of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [bosutinib results in increased expression of CASP1 mRNA] CTD PMID:39134127 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO bosutinib results in decreased expression of CCND1 protein
[SM 164 co-treated with bosutinib] results in decreased expression of CCND1 protein
CTD PMID:16489032 PMID:22241084 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Ccnd3 cyclin D3 affects localization
multiple interactions
ISO bosutinib affects the localization of CCND3 protein
[bosutinib co-treated with Imatinib Mesylate] affects the localization of CCND3 protein
CTD PMID:17129604 NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033
JBrowse link
G Cdc25a cell division cycle 25A decreases expression
multiple interactions
ISO bosutinib results in decreased expression of CDC25A protein
Imatinib Mesylate promotes the reaction [bosutinib results in decreased expression of CDC25A protein]
CTD PMID:17129604 NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO bosutinib promotes the reaction [CTNNB1 protein binds to CDH1 protein]; CTNNB1 protein promotes the reaction [bosutinib results in increased stability of CDH1 protein] CTD PMID:16489032 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity
decreases expression
ISO bosutinib results in decreased activity of CDK2 protein
bosutinib results in decreased expression of CDK2 protein
CTD PMID:17129604 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO bosutinib results in increased expression of CDKN1A protein CTD PMID:17129604 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
ISO bosutinib results in increased expression of CDKN1B protein
Imatinib Mesylate promotes the reaction [bosutinib results in increased expression of CDKN1B protein]
CTD PMID:17129604 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498
JBrowse link
G Csk C-terminal Src kinase decreases activity EXP bosutinib results in decreased activity of CSK protein CTD PMID:17114238 NCBI chr 8:66,925,650...66,944,861
Ensembl chr 8:66,925,651...66,930,274
JBrowse link
G Ctnnb1 catenin beta 1 affects localization
decreases phosphorylation
multiple interactions
ISO bosutinib affects the localization of CTNNB1 protein
bosutinib results in decreased phosphorylation of CTNNB1 protein
bosutinib inhibits the reaction [CTNNB1 protein binds to TCF4 protein]; bosutinib inhibits the reaction [SRC protein results in increased phosphorylation of CTNNB1 protein]; bosutinib promotes the reaction [CTNNB1 protein binds to CDH1 protein]; CTNNB1 protein promotes the reaction [bosutinib results in increased stability of CDH1 protein]
CTD PMID:16489032 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
JBrowse link
G Egfr epidermal growth factor receptor decreases activity ISO bosutinib results in decreased activity of EGFR protein CTD PMID:18385429 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases phosphorylation EXP bosutinib results in decreased phosphorylation of ERBB2 protein CTD PMID:18385429 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases activity EXP bosutinib results in decreased activity of FGR protein CTD PMID:17114238 NCBI chr 5:150,473,767...150,503,524
Ensembl chr 5:150,473,792...150,503,169
JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO bosutinib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Gsdmd gasdermin D multiple interactions
increases expression
ISO N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [bosutinib results in increased expression of GSDMD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [bosutinib results in increased expression of GSDMD protein]
bosutinib results in increased expression of GSDMD mRNA; bosutinib results in increased expression of GSDMD protein
CTD PMID:39134127 NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:109,422,910...109,430,722
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
ISO Acetylcysteine inhibits the reaction [bosutinib results in increased secretion of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [bosutinib results in increased secretion of IL1B protein] CTD PMID:39134127 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase decreases activity EXP bosutinib results in decreased activity of LYN protein CTD PMID:17114238 NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:21,437,084...21,554,461
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO bosutinib affects the reaction [linsidomine results in increased phosphorylation of MAPK8 protein] CTD PMID:34519134 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression
ISO N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [bosutinib results in increased expression of NLRP3 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [bosutinib results in increased expression of NLRP3 protein]
bosutinib results in increased expression of NLRP3 mRNA; bosutinib results in increased expression of NLRP3 protein
CTD PMID:39134127 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [bosutinib co-treated with linsidomine] affects the expression of PARP1 protein; bosutinib affects the reaction [linsidomine results in increased cleavage of PARP1 protein] CTD PMID:34519134 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO bosutinib inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:72,791,096...72,914,299
Ensembl chr  X:72,781,876...72,914,498
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation
multiple interactions
ISO bosutinib results in decreased phosphorylation of SRC protein
bosutinib inhibits the reaction [SRC protein results in increased phosphorylation of CTNNB1 protein]
CTD PMID:16489032 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462
JBrowse link
G Tcf4 transcription factor 4 multiple interactions ISO bosutinib inhibits the reaction [CTNNB1 protein binds to TCF4 protein] CTD PMID:16489032 NCBI chr18:65,216,840...65,563,186
Ensembl chr18:65,216,849...65,558,401
JBrowse link
G Tp53 tumor protein p53 affects activity ISO bosutinib analog affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
clozapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 increases expression ISO Clozapine results in increased expression of AARS1 protein CTD PMID:34122009 NCBI chr19:55,906,694...55,930,499
Ensembl chr19:55,906,702...55,930,497
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Clozapine results in decreased activity of ABCB11 protein CTD PMID:22646477 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
EXP
ISO
Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein]
Clozapine results in decreased activity of ABCB1 protein
CTD PMID:9111066 PMID:16810505 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B multiple interactions EXP Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter] CTD PMID:9111066 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Clozapine results in decreased activity of ABCB4 protein CTD PMID:39023798 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases activity ISO Clozapine results in decreased activity of ABCC3 protein CTD PMID:39023798 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases activity ISO Clozapine results in decreased activity of ABCC4 protein CTD PMID:39023798 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375
JBrowse link
G Abce1 ATP binding cassette subfamily E member 1 increases expression ISO Clozapine results in increased expression of ABCE1 protein CTD PMID:34122009 NCBI chr19:45,109,880...45,134,819
Ensembl chr19:45,109,906...45,134,819
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO Clozapine results in increased expression of ABCG1 mRNA CTD PMID:17346280 NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] CTD PMID:18834354 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493
JBrowse link
G Ablim2 actin binding LIM protein family, member 2 increases expression ISO Clozapine results in increased expression of ABLIM2 mRNA CTD PMID:17346280 NCBI chr14:79,090,046...79,214,986
Ensembl chr14:79,090,923...79,214,972
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression ISO Clozapine results in increased expression of ACAT2 mRNA CTD PMID:17052361 NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095
JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression ISO Clozapine results in increased expression of ACOT2 protein CTD PMID:34122009 NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:109,342,646...109,350,502
JBrowse link
G Acot7 acyl-CoA thioesterase 7 decreases expression ISO Clozapine results in decreased expression of ACOT7 protein CTD PMID:34122009 NCBI chr 5:167,969,284...168,062,033
Ensembl chr 5:167,968,895...168,062,033
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA CTD PMID:23226405 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136
JBrowse link
G Actb actin, beta decreases expression ISO Clozapine results in decreased expression of ACTB protein CTD PMID:34122009 NCBI chr12:16,776,664...16,779,634
Ensembl chr12:16,776,661...16,780,242
JBrowse link
G Actbl2 actin, beta-like 2 increases expression ISO Clozapine results in increased expression of ACTBL2 protein CTD PMID:34122009 NCBI chr 2:44,591,391...44,594,138
Ensembl chr 2:44,591,391...44,594,138
JBrowse link
G Actr3 actin related protein 3 decreases expression ISO Clozapine results in decreased expression of ACTR3 protein CTD PMID:34122009 NCBI chr13:39,353,413...39,396,509
Ensembl chr13:39,353,079...39,396,711
JBrowse link
G Actr5 actin related protein 5 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of ACTR5 protein CTD PMID:34122009 NCBI chr 3:167,702,299...167,715,736
Ensembl chr 3:167,702,482...167,715,730
JBrowse link
G Adam1a ADAM metallopeptidase domain 1a decreases expression EXP Clozapine results in decreased expression of ADAM1A mRNA CTD PMID:16715494 NCBI chr12:40,674,460...40,680,988
Ensembl chr12:40,676,918...40,684,619
JBrowse link
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of ADAMTS12 protein CTD PMID:34122009 NCBI chr 2:61,759,975...62,054,716
Ensembl chr 2:61,759,987...62,054,716
JBrowse link
G Adcy5 adenylate cyclase 5 affects response to substance
multiple interactions
ISO ADCY5 protein affects the susceptibility to Clozapine
SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine]
CTD PMID:12223546 NCBI chr11:78,976,861...79,123,343
Ensembl chr11:78,976,861...79,123,343
JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of ADH5 protein CTD PMID:34122009 NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:229,648,501...229,665,232
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression
increases expression
multiple interactions
ISO
EXP
Clozapine results in decreased expression of ADIPOQ protein
Clozapine results in increased expression of ADIPOQ protein
Clozapine results in increased expression of ADIPOQ mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]
CTD PMID:17933447 PMID:18162013 PMID:20564506 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Clozapine results in decreased expression of ADORA2A mRNA CTD PMID:17266109 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions EXP Clozapine binds to and results in decreased activity of ADRA1A protein CTD PMID:16545797 NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534
JBrowse link
G Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 decreases expression ISO Clozapine results in decreased expression of AGPAT1 mRNA CTD PMID:14647396 NCBI chr20:4,140,565...4,149,531
Ensembl chr20:4,140,565...4,150,445
JBrowse link
G Agt angiotensinogen multiple interactions ISO Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]] CTD PMID:11549694 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
JBrowse link
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 increases expression ISO Clozapine results in increased expression of AIMP1 protein CTD PMID:34122009 NCBI chr 2:223,825,930...223,849,477
Ensembl chr 2:223,825,931...223,849,994
JBrowse link
G Ak1 adenylate kinase 1 decreases expression ISO Clozapine results in decreased expression of AK1 protein CTD PMID:34122009 NCBI chr 3:36,310,113...36,320,760
Ensembl chr 3:36,310,197...36,320,757
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
decreases expression
increases phosphorylation
ISO
EXP
Clozapine results in increased expression of AKT1 mRNA; Clozapine results in increased expression of AKT1 protein
Clozapine results in decreased expression of AKT1 mRNA
Clozapine results in increased phosphorylation of AKT1 protein
CTD PMID:15860345 PMID:19440698 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Akt2 AKT serine/threonine kinase 2 increases expression EXP Clozapine results in increased expression of AKT2 mRNA CTD PMID:15860345 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420
JBrowse link
G Alb albumin multiple interactions
affects binding
EXP
ISO
Clozapine results in decreased expression of and results in decreased reduction of ALB protein
Clozapine binds to ALB protein
[[[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine] which affects the activity of ALB protein; [[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine; [stearic acid binds to ALB protein] which affects the susceptibility to Clozapine; stearic acid inhibits the reaction [Clozapine binds to ALB protein]
CTD PMID:31400341 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO Clozapine results in increased expression of ALDH1A1 mRNA CTD PMID:17266109 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Clozapine results in increased expression of ALDOA mRNA CTD PMID:15860345 NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211
JBrowse link
G Aldob aldolase, fructose-bisphosphate B increases expression
decreases expression
ISO Clozapine results in increased expression of ALDOB protein
Clozapine results in decreased expression of ALDOB protein
CTD PMID:34122009 PMID:36482696 NCBI chr 5:68,684,541...68,697,582
Ensembl chr 5:68,684,542...68,716,740
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression
increases expression
ISO
EXP
Clozapine results in decreased expression of ALDOC mRNA
Clozapine results in increased expression of ALDOC mRNA
CTD PMID:15860345 PMID:16465460 NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,715,489...63,719,133
JBrowse link
G Alpp alkaline phosphatase, placental multiple interactions ISO Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA] CTD PMID:16036225 NCBI chr 9:95,213,763...95,216,509
Ensembl chr 9:95,213,374...95,219,451
JBrowse link
G Alyref Aly/REF export factor decreases expression ISO Clozapine results in decreased expression of ALYREF protein CTD PMID:34122009 NCBI chr10:106,369,750...106,373,395
Ensembl chr10:106,369,750...106,373,395
JBrowse link
G Anxa1 annexin A1 decreases expression ISO Clozapine results in decreased expression of ANXA1 protein CTD PMID:34122009 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831
JBrowse link
G Anxa5 annexin A5 decreases expression ISO Clozapine results in decreased expression of ANXA5 protein CTD PMID:34122009 NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400
JBrowse link
G Anxa6 annexin A6 decreases expression ISO Clozapine results in decreased expression of ANXA6 protein CTD PMID:34122009 NCBI chr10:39,602,106...39,657,183
Ensembl chr10:39,602,106...39,657,359
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Clozapine results in decreased expression of AP1S1 mRNA CTD PMID:17175557 NCBI chr12:25,261,958...25,272,483
Ensembl chr12:25,262,036...25,272,483
JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 increases expression EXP Clozapine results in increased expression of AP2B1 mRNA CTD PMID:15860345 NCBI chr10:68,596,925...68,702,547
Ensembl chr10:68,597,093...68,702,539
JBrowse link
G Ap3b1 adaptor related protein complex 3 subunit beta 1 increases expression ISO Clozapine results in increased expression of AP3B1 protein CTD PMID:34122009 NCBI chr 2:27,331,241...27,535,683
Ensembl chr 2:27,334,900...27,537,702
JBrowse link
G Apoa5 apolipoprotein A5 affects response to substance EXP APOA5 gene polymorphism affects the susceptibility to Clozapine CTD PMID:17726453 NCBI chr 8:55,446,329...55,460,509
Ensembl chr 8:55,456,899...55,460,507
JBrowse link
G Apod apolipoprotein D increases expression ISO Clozapine results in increased expression of APOD mRNA; Clozapine results in increased expression of APOD protein CTD PMID:11158250 PMID:14647396 PMID:17266109 NCBI chr11:82,936,216...82,957,264
Ensembl chr11:82,936,038...82,957,263
JBrowse link
G App amyloid beta precursor protein increases expression ISO Clozapine results in increased expression of APP protein CTD PMID:36482696 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein decreases expression EXP Clozapine results in decreased expression of ARC mRNA CTD PMID:18208916 NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220
JBrowse link
G Arhgef9 Cdc42 guanine nucleotide exchange factor 9 decreases expression ISO Clozapine results in decreased expression of ARHGEF9 mRNA CTD PMID:17266109 NCBI chr  X:63,929,168...64,087,267
Ensembl chr  X:63,929,176...64,087,104
JBrowse link
G Arl8a ARF like GTPase 8A decreases expression ISO Clozapine results in decreased expression of ARL8A protein CTD PMID:34122009 NCBI chr13:49,137,632...49,146,633
Ensembl chr13:49,137,632...49,146,633
JBrowse link
G Armt1 acidic residue methyltransferase 1 increases expression ISO Clozapine results in increased expression of DCPH1 protein CTD PMID:34122009 NCBI chr 1:43,299,916...43,323,675
Ensembl chr 1:43,299,826...43,323,670
JBrowse link
G Arpc4 actin related protein 2/3 complex, subunit 4 affects expression ISO Clozapine affects the expression of ARPC4 mRNA CTD PMID:14647396 NCBI chr 4:148,077,799...148,088,427
Ensembl chr 4:148,077,240...148,088,428
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Clozapine results in increased expression of ASAH1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr16:57,669,927...57,701,349
Ensembl chr16:57,669,750...57,718,305
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Clozapine results in increased expression of ASNS mRNA; Clozapine results in increased expression of ASNS protein CTD PMID:15342952 PMID:17175557 PMID:36482696 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050
JBrowse link
G Asph aspartate-beta-hydroxylase increases expression ISO Clozapine results in increased expression of ASPH protein CTD PMID:34122009 NCBI chr 5:27,398,933...27,611,519
Ensembl chr 5:27,398,949...27,611,215
JBrowse link
G Ass1 argininosuccinate synthase 1 increases expression ISO Clozapine results in increased expression of ASS1 protein CTD PMID:34122009 NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:35,144,999...35,194,627
JBrowse link
G Atad3a ATPase family, AAA domain containing 3A decreases expression ISO Clozapine results in decreased expression of ATAD3A protein CTD PMID:34122009 NCBI chr 5:171,632,545...171,652,725
Ensembl chr 5:171,632,547...171,652,725
JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 increases expression ISO Clozapine results in increased expression of ATP2A3 protein CTD PMID:34122009 NCBI chr10:58,079,710...58,111,279
Ensembl chr10:58,079,852...58,111,278
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression EXP Clozapine results in decreased expression of ATP5F1B protein CTD PMID:19441803 NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:1,099,860...1,106,462
JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b increases expression ISO Clozapine results in increased expression of ATP5PB protein CTD PMID:34122009 NCBI chr 2:196,112,459...196,123,737
Ensembl chr 2:196,112,108...196,124,387
JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A decreases expression ISO Clozapine results in decreased expression of ATP6V1A protein CTD PMID:34122009 NCBI chr11:70,066,800...70,120,603
Ensembl chr11:70,035,134...70,120,603
JBrowse link
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 decreases expression ISO Clozapine results in decreased expression of ATP6V1B1 protein CTD PMID:34122009 NCBI chr 4:117,781,444...117,800,103
Ensembl chr 4:117,781,444...117,800,103
JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 decreases expression EXP
ISO
Clozapine results in decreased expression of ATP6V1B2 protein CTD PMID:19441803 PMID:34122009 NCBI chr16:25,384,254...25,408,388
Ensembl chr16:25,384,257...25,408,839
JBrowse link
G Atxn10 ataxin 10 increases expression ISO Clozapine results in increased expression of ATXN10 protein CTD PMID:34122009 NCBI chr 7:118,321,516...118,444,967
Ensembl chr 7:118,319,490...118,445,636
JBrowse link
G Axin2 axin 2 decreases expression EXP Clozapine results in decreased expression of AXIN2 mRNA CTD PMID:16715494 NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575
JBrowse link
G Bace2 beta-secretase 2 increases expression ISO Clozapine results in increased expression of BACE2 protein CTD PMID:36482696 NCBI chr11:50,176,852...50,258,948
Ensembl chr11:50,176,621...50,259,008
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
decreases expression
ISO
EXP
Clozapine results in increased expression of BAX mRNA; Clozapine results in increased expression of BAX protein
CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]
Clozapine results in decreased expression of BAX protein
CTD PMID:16160616 PMID:17069804 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Baz1b bromodomain adjacent to zinc finger domain, 1B multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of BAZ1B protein CTD PMID:34122009 NCBI chr12:27,068,541...27,126,511
Ensembl chr12:27,068,541...27,126,511
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases expression ISO Clozapine results in decreased expression of BCAR1 protein CTD PMID:34122009 NCBI chr19:56,588,500...56,623,190
Ensembl chr19:56,588,500...56,623,190
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Clozapine results in increased expression of BCL2 mRNA; Clozapine results in increased expression of BCL2 protein CTD PMID:15126120 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Bcl2l14 Bcl2-like 14 decreases expression ISO Clozapine results in decreased expression of BCL2L14 protein CTD PMID:34122009 NCBI chr 4:168,948,919...168,989,450
Ensembl chr 4:168,948,946...168,990,079
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
increases expression
EXP Clozapine results in decreased expression of BDNF mRNA
Clozapine results in increased expression of BDNF mRNA; Clozapine results in increased expression of BDNF protein
CTD PMID:11488957 PMID:12478621 PMID:17442489 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
JBrowse link
G Bet1l Bet1 golgi vesicular membrane trafficking protein-like decreases expression EXP Clozapine results in decreased expression of BET1L mRNA CTD PMID:15860345 NCBI chr 1:205,361,041...205,365,036
Ensembl chr 1:205,361,041...205,364,706
JBrowse link
G Bik BCL2-interacting killer multiple interactions
increases expression
ISO CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA] CTD PMID:16160616 NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:116,552,303...116,571,317
JBrowse link
G Bptf bromodomain PHD finger transcription factor decreases expression ISO Clozapine results in decreased expression of BPTF mRNA CTD PMID:14647396 NCBI chr10:92,480,007...92,582,485
Ensembl chr10:92,480,007...92,582,413
JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 increases expression ISO Clozapine results in increased expression of BZW1 protein CTD PMID:34122009 NCBI chr 9:67,424,860...67,438,656
Ensembl chr 9:67,424,866...67,439,684
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A decreases expression ISO
EXP
Clozapine results in decreased expression of CACNA1A mRNA CTD PMID:14647396 PMID:16715494 NCBI chr19:40,425,560...40,724,810
Ensembl chr19:40,425,560...40,724,599
JBrowse link
G Calcoco1 calcium binding and coiled coil domain 1 increases expression ISO Clozapine results in increased expression of CALCOCO1 protein CTD PMID:36482696 NCBI chr 7:135,713,208...135,728,044
Ensembl chr 7:135,713,208...135,727,928
JBrowse link
G Calm2 calmodulin 2 increases expression EXP Clozapine results in increased expression of CALM2 mRNA CTD PMID:19289156 NCBI chr 6:12,845,170...12,857,830
Ensembl chr15:64,519,554...64,520,657
Ensembl chr 6:64,519,554...64,520,657
JBrowse link
G Calr calreticulin decreases expression ISO Clozapine results in decreased expression of CALR protein CTD PMID:34122009 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236
JBrowse link
G Calu calumenin decreases expression ISO Clozapine results in decreased expression of CALU protein CTD PMID:34122009 NCBI chr 4:58,914,456...58,941,957
Ensembl chr 4:58,914,421...58,941,956
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases expression
increases expression
ISO
EXP
Clozapine results in decreased expression of CAMK2A mRNA
Clozapine results in increased expression of CAMK2A mRNA
Clozapine results in decreased expression of CAMK2A protein
CTD PMID:15860345 PMID:17266109 PMID:19289156 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression EXP Clozapine results in decreased expression of CAMK2B mRNA CTD PMID:15860345 NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta decreases expression EXP Clozapine results in decreased expression of CAMK2D mRNA CTD PMID:15860345 NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:217,698,551...217,960,276
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV increases expression
decreases expression
EXP Clozapine results in increased expression of CAMK4 mRNA
Clozapine results in decreased expression of CAMK4 protein
CTD PMID:15860345 PMID:19289156 NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,857,146...25,077,193
JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 decreases expression EXP Clozapine results in decreased expression of CAMKK1 protein CTD PMID:19289156 NCBI chr10:58,135,872...58,159,023
Ensembl chr10:58,135,915...58,159,010
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 decreases expression EXP Clozapine results in decreased expression of CAMKK2 protein CTD PMID:19289156 NCBI chr12:39,451,828...39,505,719
Ensembl chr12:39,451,834...39,514,964
JBrowse link
G Canx calnexin decreases expression ISO Clozapine results in decreased expression of CANX protein CTD PMID:34122009 NCBI chr10:35,124,941...35,157,954
Ensembl chr10:35,124,941...35,157,857
JBrowse link
G Cars1 cysteinyl-tRNA synthetase 1 increases expression ISO Clozapine results in increased expression of CARS1 protein CTD PMID:34122009 NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:208,182,788...208,225,407
JBrowse link
G Cartpt CART prepropeptide decreases expression EXP Clozapine results in decreased expression of CARTPT mRNA CTD PMID:14696011 NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:32,989,215...32,999,712
JBrowse link
G Casp1 caspase 1 increases activity ISO Clozapine results in increased activity of CASP1 protein CTD PMID:34935985 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
Clozapine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP3 protein]
CTD PMID:22700542 PMID:24709159 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Clozapine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512
JBrowse link
G Cat catalase multiple interactions ISO Clozapine inhibits the reaction [Corticosterone results in increased activity of CAT protein]; Clozapine inhibits the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]] CTD PMID:14730115 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 increases expression ISO Clozapine results in increased expression of CCAR1 protein CTD PMID:34122009 NCBI chr20:31,228,624...31,271,233
Ensembl chr20:31,228,624...31,271,227
JBrowse link
G Ccdc47 coiled-coil domain containing 47 increases expression
multiple interactions
ISO Clozapine results in increased expression of CCDC47 protein
[Cuprizone co-treated with Clozapine] results in increased expression of CCDC47 protein
CTD PMID:34122009 NCBI chr10:91,630,101...91,648,626
Ensembl chr10:91,630,106...91,648,626
JBrowse link
G Cck cholecystokinin multiple interactions
increases expression
EXP Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein]
Clozapine results in increased expression of CCK mRNA
CTD PMID:10974607 PMID:16567023 NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:130,031,013...130,037,686
JBrowse link
G Cckbr cholecystokinin B receptor increases expression ISO Clozapine results in increased expression of CCKBR mRNA CTD PMID:17266109 NCBI chr 1:169,183,578...169,193,583
Ensembl chr 1:169,183,194...169,193,745
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 decreases expression ISO Clozapine results in decreased expression of CCL1 mRNA CTD PMID:17346280 NCBI chr10:67,625,962...67,628,740
Ensembl chr10:67,625,962...67,628,790
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Clozapine results in decreased expression of CCND1 mRNA CTD PMID:15860345 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Ccnd3 cyclin D3 increases expression EXP Clozapine results in increased expression of CCND3 mRNA CTD PMID:15860345 NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033
JBrowse link
G Ccnl1 cyclin L1 increases expression EXP Clozapine results in increased expression of CCNL1 mRNA CTD PMID:15860345 NCBI chr 2:152,495,169...152,508,855
Ensembl chr 2:152,495,172...152,507,468
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 decreases expression ISO Clozapine results in decreased expression of CCT7 protein CTD PMID:34122009 NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:119,546,730...119,563,973
JBrowse link
G Cd276 Cd276 molecule decreases expression ISO Clozapine results in decreased expression of CD276 protein CTD PMID:34122009 NCBI chr 8:67,833,587...67,863,918
Ensembl chr 8:67,829,048...67,864,505
JBrowse link
G Cd63 Cd63 molecule increases expression ISO Clozapine results in increased expression of CD63 protein CTD PMID:36482696 NCBI chr 7:1,909,538...1,924,937
Ensembl chr 7:1,922,169...1,924,938
JBrowse link
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase increases expression ISO Clozapine results in increased expression of CDIPT protein CTD PMID:34122009 NCBI chr 1:191,013,632...191,017,943
Ensembl chr 1:191,013,463...191,017,971
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP Clozapine results in increased expression of CDK4 mRNA CTD PMID:15860345 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163
JBrowse link
G Cdk5 cyclin-dependent kinase 5 increases expression EXP Clozapine results in increased expression of CDK5 mRNA CTD PMID:15860345 NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:11,647,141...11,652,777
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression ISO Clozapine results in increased expression of CDK5R1 mRNA CTD PMID:17266109 NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression
ISO Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]
Clozapine results in increased expression of CEBPA mRNA; Clozapine results in increased expression of CEBPA protein
CTD PMID:20564506 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309
JBrowse link
G Cenpv centromere protein V increases expression ISO Clozapine results in increased expression of CENPV protein CTD PMID:34122009 NCBI chr10:47,713,778...47,746,800
Ensembl chr10:47,713,778...47,727,679
JBrowse link
G Cfap210 cilia and flagella associated protein 210 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of CFAP210 protein CTD PMID:34122009 NCBI chr 3:74,928,368...74,962,508
Ensembl chr 3:74,927,880...74,962,497
JBrowse link
G Chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of CHCHD2 protein CTD PMID:34122009 NCBI chr12:32,464,847...32,470,871
Ensembl chr12:32,464,824...32,470,871
JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 decreases expression ISO Clozapine results in decreased expression of CHD4 protein CTD PMID:34122009 NCBI chr 4:159,584,623...159,617,867
Ensembl chr 4:159,584,654...159,617,866
JBrowse link
G Chga chromogranin A decreases expression
increases expression
EXP Clozapine results in decreased expression of CHGA mRNA
Clozapine results in increased expression of CHGA mRNA
CTD PMID:12437575 NCBI chr 6:127,460,895...127,472,238
Ensembl chr 6:127,460,854...127,472,237
JBrowse link
G Chl1 cell adhesion molecule L1-like decreases expression ISO Clozapine results in decreased expression of CHL1 mRNA CTD PMID:14647396 NCBI chr 4:137,847,648...138,062,077
Ensembl chr 4:137,847,895...138,062,077
JBrowse link
G Chn1 chimerin 1 decreases expression ISO Clozapine results in decreased expression of CHN1 mRNA CTD PMID:14647396 NCBI chr 3:78,917,329...79,084,040
Ensembl chr 3:78,917,329...79,084,197
JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression ISO Clozapine results in increased expression of CHORDC1 protein CTD PMID:34122009 NCBI chr 8:23,650,721...23,674,786
Ensembl chr 8:23,650,865...23,677,696
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 affects binding
increases expression
multiple interactions
ISO
EXP
Clozapine analog binds to CHRM1 protein; Clozapine binds to CHRM1 protein
Clozapine results in increased expression of CHRM1 protein
Clozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein]
CTD PMID:11997696 PMID:16983399 PMID:18806925 NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602
JBrowse link
G Ckap4 cytoskeleton-associated protein 4 increases expression ISO Clozapine results in increased expression of CKAP4 protein CTD PMID:34122009 NCBI chr 7:21,118,527...21,126,624
Ensembl chr 7:21,118,085...21,126,624
JBrowse link
G Clic1 chloride intracellular channel 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of CLIC1 protein CTD PMID:34122009 NCBI chr20:3,769,522...3,778,367
Ensembl chr20:3,769,527...3,778,367
JBrowse link
G Clic4 chloride intracellular channel 4 increases expression ISO Clozapine results in increased expression of CLIC4 protein CTD PMID:34122009 NCBI chr 5:152,737,371...152,797,118
Ensembl chr 5:152,737,371...152,797,118
JBrowse link
G Clock clock circadian regulator affects response to substance ISO CLOCK gene SNP affects the susceptibility to Clozapine CTD PMID:15331141 NCBI chr14:32,262,747...32,346,872
Ensembl chr14:32,262,750...32,346,872
JBrowse link
G Clta clathrin, light chain A decreases expression EXP Clozapine results in decreased expression of CLTA mRNA CTD PMID:15860345 NCBI chr 5:63,022,046...63,059,223
Ensembl chr 5:63,041,184...63,059,215
JBrowse link
G Cltb clathrin, light chain B decreases expression EXP Clozapine results in decreased expression of CLTB mRNA CTD PMID:15860345 NCBI chr17:10,006,416...10,024,278
Ensembl chr17:10,006,656...10,024,915
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression
increases expression
ISO Clozapine results in decreased expression of CNP mRNA
Clozapine results in decreased expression of CNP protein
Clozapine results in increased expression of CNP mRNA
CTD PMID:17266109 PMID:34122009 NCBI chr10:86,011,504...86,018,063
Ensembl chr10:86,011,495...86,018,063
JBrowse link
G Coil coilin increases expression EXP Clozapine results in increased expression of COIL mRNA CTD PMID:16715494 NCBI chr10:74,286,279...74,307,597
Ensembl chr10:74,286,840...74,307,595
JBrowse link
G Col5a2 collagen type V alpha 2 chain multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of COL5A2 protein CTD PMID:34122009 NCBI chr 9:54,940,768...55,090,151
Ensembl chr 9:54,940,764...55,090,150
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions
affects response to substance
increases response to substance
EXP
ISO
[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]
COMT protein affects the susceptibility to Clozapine
COMT gene polymorphism results in increased susceptibility to Clozapine
CTD PMID:15190105 PMID:17123785 NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533
JBrowse link
G Cops3 COP9 signalosome subunit 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of COPS3 protein CTD PMID:34122009 NCBI chr10:45,117,664...45,151,868
Ensembl chr10:45,117,657...45,152,074
JBrowse link
G Coro1b coronin 1B decreases expression ISO Clozapine results in decreased expression of CORO1B protein CTD PMID:34122009 NCBI chr 1:210,872,437...210,877,876
Ensembl chr 1:210,871,841...210,877,876
JBrowse link
G Cplx2 complexin 2 decreases expression ISO Clozapine results in decreased expression of CPLX2 mRNA CTD PMID:17266109 NCBI chr17:10,224,673...10,297,974
Ensembl chr17:10,228,449...10,297,467
JBrowse link
G Cpn1 carboxypeptidase N subunit 1 increases expression EXP Clozapine results in increased expression of CPN1 mRNA CTD PMID:16715494 NCBI chr 1:252,793,786...252,822,675
Ensembl chr 1:252,793,423...252,822,664
JBrowse link
G Cpne1 copine 1 decreases expression ISO Clozapine results in decreased expression of CPNE1 protein CTD PMID:34122009 NCBI chr 3:165,047,615...165,089,994 JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions EXP [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA CTD PMID:23226405 NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:127,893,207...127,910,818
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases phosphorylation
ISO Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein]
Clozapine results in decreased phosphorylation of CREB1 protein
CTD PMID:12871586 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Clozapine results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386
JBrowse link
G Crhbp corticotropin releasing hormone binding protein decreases expression EXP Clozapine results in decreased expression of CRHBP mRNA CTD PMID:16715494 NCBI chr 2:28,427,139...28,439,446
Ensembl chr 2:28,427,139...28,439,446
JBrowse link
G Crp C-reactive protein increases expression ISO Clozapine results in increased expression of CRP protein CTD PMID:17685758 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514
JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA] CTD PMID:16160616 NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 decreases expression EXP Clozapine results in decreased expression of CSNK2A1 mRNA CTD PMID:16715494 NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698
JBrowse link
G Cst3 cystatin C increases expression ISO Clozapine results in increased expression of CST3 mRNA CTD PMID:14647396 NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937
JBrowse link
G Cstf1 cleavage stimulation factor subunit 1 decreases expression ISO Clozapine results in decreased expression of CSTF1 protein CTD PMID:34122009 NCBI chr 3:181,562,953...181,574,727
Ensembl chr 3:181,562,955...181,574,727
JBrowse link
G Cstf2 cleavage stimulation factor subunit 2 decreases expression ISO Clozapine results in decreased expression of CSTF2 protein CTD PMID:34122009 NCBI chr  X:101,546,809...101,572,760
Ensembl chr  X:101,546,819...101,572,764
JBrowse link
G Ctbp1 C-terminal binding protein 1 increases expression ISO Clozapine results in increased expression of CTBP1 protein CTD PMID:34122009 NCBI chr14:81,679,956...81,707,331
Ensembl chr14:81,679,765...81,707,554
JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions
EXP Clozapine results in increased expression of CTNNB1 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]
CTD PMID:16144542 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
JBrowse link
G Ctrl chymotrypsin-like increases expression EXP Clozapine results in increased expression of CTRL mRNA CTD PMID:16715494 NCBI chr19:50,737,078...50,740,659
Ensembl chr19:50,737,079...50,738,979
JBrowse link
G Ctsk cathepsin K increases expression EXP Clozapine results in increased expression of CTSK mRNA CTD PMID:16715494 NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582
JBrowse link
G Cttn cortactin increases expression ISO Clozapine results in increased expression of CTTN protein CTD PMID:34122009 NCBI chr 1:209,029,048...209,064,577
Ensembl chr 1:209,029,048...209,058,211
JBrowse link
G Cul2 cullin 2 increases expression ISO Clozapine results in increased expression of CUL2 protein CTD PMID:34122009 NCBI chr17:58,864,274...58,905,447
Ensembl chr17:58,864,274...58,905,132
JBrowse link
G Cul3 cullin 3 increases expression ISO Clozapine results in increased expression of CUL3 protein CTD PMID:34122009 NCBI chr 9:89,040,987...89,118,775
Ensembl chr 9:89,040,987...89,118,427
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression
decreases secretion
multiple interactions
increases secretion
ISO
EXP
Clozapine results in decreased expression of CXCL1 mRNA
Clozapine results in decreased secretion of CXCL1 protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of CXCL1 protein]
CTD PMID:17346280 PMID:34935985 PMID:36482696 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO Clozapine results in decreased secretion of CXCL10 protein CTD PMID:36482696 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression
decreases secretion
ISO Clozapine results in decreased expression of CXCL1 mRNA
Clozapine results in decreased secretion of CXCL1 protein
CTD PMID:17346280 PMID:36482696 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624
JBrowse link
G Cxhxorf49 similar to human chromosome X open reading frame 49 increases expression ISO Clozapine results in increased expression of CXORF49 protein CTD PMID:34122009 NCBI chr  X:70,951,401...70,955,380
Ensembl chr  X:70,951,410...70,955,378
JBrowse link
G Cyb5b cytochrome b5 type B increases expression EXP Clozapine results in increased expression of CYB5B mRNA CTD PMID:19441803 NCBI chr19:51,972,611...52,006,477
Ensembl chr19:51,972,547...52,026,980
JBrowse link
G Cyb5r1 cytochrome b5 reductase 1 increases expression ISO Clozapine results in increased expression of CYB5R1 protein CTD PMID:34122009 NCBI chr13:48,401,061...48,407,466
Ensembl chr13:48,399,106...48,407,465
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases metabolic processing
EXP
ISO
Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Clozapine results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of Clozapine
CTD PMID:18493746 PMID:18809730 PMID:33814510 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases response to substance
multiple interactions
increases metabolic processing
increases expression
affects metabolic processing
affects response to substance
decreases metabolic processing
ISO
EXP
CYP1A2 gene SNP results in decreased susceptibility to Clozapine
Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CYP1A2 protein results in increased metabolism of Clozapine
Clozapine results in increased expression of CYP1A2 mRNA
CYP1A2 gene polymorphism affects the metabolism of Clozapine; CYP1A2 protein affects the metabolism of Clozapine; CYP1A2 protein polymorphism affects the metabolism of Clozapine
[Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Smoke affects the reaction [CYP1A2 gene polymorphism affects the metabolism of Clozapine]; Smoke promotes the reaction [CYP1A2 protein results in increased metabolism of Clozapine]
CYP1A2 gene SNP affects the susceptibility to Clozapine; CYP1A2 protein affects the susceptibility to Clozapine
CYP1A2 gene SNP results in increased metabolism of Clozapine; CYP1A2 protein results in increased metabolism of Clozapine
CYP1A2 gene SNP results in decreased metabolism of Clozapine
CTD PMID:11151749 PMID:11763009 PMID:12919186 PMID:12969762 PMID:15206669 More... NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
decreases activity
ISO CYP1B1 protein results in increased metabolism of Clozapine
Clozapine results in decreased activity of CYP1B1 protein
CTD PMID:18809730 PMID:33814510 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
increases metabolic processing
ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine
CYP2C19 protein results in increased metabolism of Clozapine
CTD PMID:18809730 PMID:23397584 PMID:27320963 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of Clozapine CTD PMID:18809730 PMID:27320963
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
increases metabolic processing
multiple interactions
ISO CYP2D6 protein affects the metabolism of Clozapine
CYP2D6 protein results in increased metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine
CTD PMID:15286053 PMID:18809730 PMID:23397584 PMID:27320963 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases metabolic processing ISO CYP2J2 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
decreases activity
affects metabolic processing
multiple interactions
ISO CYP3A4 protein results in increased metabolism of Clozapine
Clozapine results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]
CTD PMID:15286053 PMID:18809730 PMID:21402137 PMID:23397584 PMID:27320963 More... NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154
JBrowse link
G Dab1 DAB adaptor protein 1 increases expression EXP Clozapine results in increased expression of DAB1 mRNA CTD PMID:19359144 NCBI chr 5:123,621,510...124,742,585
Ensembl chr 5:124,369,415...124,742,584
JBrowse link
G Dab2 DAB adaptor protein 2 increases expression ISO Clozapine results in increased expression of DAB2 protein CTD PMID:36482696 NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:57,242,064...57,294,888
JBrowse link
G Daglb diacylglycerol lipase, beta increases expression ISO Clozapine results in increased expression of DAGLB protein CTD PMID:36482696 NCBI chr12:16,173,345...16,215,777
Ensembl chr12:16,173,345...16,215,758
JBrowse link
G Dcaf6 DDB1 and CUL4 associated factor 6 decreases expression ISO Clozapine results in decreased expression of DCAF6 mRNA CTD PMID:14647396 NCBI chr13:80,159,282...80,260,510
Ensembl chr13:80,159,321...80,260,510
JBrowse link
G Dclk1 doublecortin-like kinase 1 increases expression ISO
EXP
Clozapine results in increased expression of DCLK1 mRNA CTD PMID:15860345 PMID:18797397 NCBI chr 2:141,567,215...141,861,088
Ensembl chr 2:141,571,983...141,861,090
JBrowse link
G Ddc dopa decarboxylase multiple interactions
increases expression
ISO Clozapine results in increased expression of and results in increased activity of DDC protein
Clozapine results in increased expression of DDC mRNA
CTD PMID:16415089 NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806
JBrowse link
G Ddx46 DEAD-box helicase 46 increases expression ISO Clozapine results in increased expression of DDX46 protein CTD PMID:34122009 NCBI chr17:8,947,237...8,993,705
Ensembl chr17:8,947,237...8,990,247
JBrowse link
G Dennd10 DENN domain containing 10 increases expression EXP Clozapine results in increased expression of DENND10 mRNA CTD PMID:16715494 NCBI chr 1:269,937,023...269,960,506
Ensembl chr 1:269,936,895...269,962,853
JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Clozapine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:151,581,502...151,586,233
JBrowse link
G Dgcr6 DiGeorge syndrome critical region gene 6 decreases expression ISO Clozapine results in decreased expression of DGCR6 protein CTD PMID:34122009 NCBI chr11:96,432,024...96,442,766
Ensembl chr11:96,432,024...96,437,255
JBrowse link
G Dgka diacylglycerol kinase, alpha decreases expression EXP Clozapine results in decreased expression of DGKA mRNA CTD PMID:15860345 NCBI chr 7:1,733,247...1,761,181
Ensembl chr 7:1,733,248...1,759,569
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression ISO Clozapine results in increased expression of DHCR24 protein CTD PMID:34122009 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression ISO Clozapine results in increased expression of DHCR7 mRNA CTD PMID:17052361 NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382
JBrowse link
G Dhx30 DExH-box helicase 30 increases expression ISO Clozapine results in increased expression of DHX30 protein CTD PMID:34122009 NCBI chr 8:118,943,186...118,975,319
Ensembl chr 8:118,943,187...118,975,592
JBrowse link
G Dhx38 DEAH-box helicase 38 decreases expression ISO Clozapine results in decreased expression of DHX38 protein CTD PMID:34122009 NCBI chr19:54,422,418...54,439,434
Ensembl chr19:54,422,418...54,439,423
JBrowse link
G Disc1 DISC1 scaffold protein decreases response to substance
affects response to substance
ISO DISC1 gene mutant form results in decreased susceptibility to Clozapine
DISC1 protein affects the susceptibility to Clozapine
CTD PMID:20531374 NCBI chr19:69,911,548...70,120,970
Ensembl chr19:69,911,976...70,120,970
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase decreases expression
increases expression
EXP
ISO
Clozapine results in decreased expression of DLAT mRNA
Clozapine results in increased expression of DLAT protein
CTD PMID:15860345 PMID:34122009 NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:59,868,214...59,900,818
Ensembl chr 1:59,868,214...59,900,818
JBrowse link
G Dlg2 discs large MAGUK scaffold protein 2 increases expression ISO Clozapine results in increased expression of DLG2 protein CTD PMID:34122009 NCBI chr 1:153,864,545...155,916,238
Ensembl chr 1:153,865,299...155,916,215
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase decreases expression ISO Clozapine results in decreased expression of DLST protein CTD PMID:34122009 NCBI chr 6:110,489,576...110,512,841
Ensembl chr 6:110,489,392...110,514,357
JBrowse link
G Dnah11 dynein, axonemal, heavy chain 11 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of DNAH11 protein CTD PMID:34122009 NCBI chr 6:144,982,130...145,298,523
Ensembl chr 6:144,973,797...145,298,692
JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of DNAJA3 protein CTD PMID:34122009 NCBI chr10:11,361,168...11,386,599
Ensembl chr10:11,361,168...11,386,599
JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 increases expression ISO Clozapine results in increased expression of DNAJB11 protein CTD PMID:34122009 NCBI chr11:91,656,334...91,672,800
Ensembl chr11:91,656,335...91,672,800
JBrowse link
G Dpf1 double PHD fingers 1 affects expression ISO Clozapine affects the expression of DPF1 mRNA CTD PMID:14647396 NCBI chr 1:93,729,683...93,743,425
Ensembl chr 1:93,726,970...93,743,425
JBrowse link
G Dpp3 dipeptidylpeptidase 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of DPP3 protein CTD PMID:34122009 NCBI chr 1:211,634,067...211,657,898
Ensembl chr 1:211,634,068...211,658,310
JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 decreases expression ISO Clozapine results in decreased expression of DPYSL3 protein CTD PMID:34122009 NCBI chr18:35,625,357...35,731,152
Ensembl chr18:35,625,357...35,731,152
JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 decreases expression ISO Clozapine results in decreased expression of DPYSL4 protein CTD PMID:34122009 NCBI chr 1:203,312,646...203,328,523
Ensembl chr 1:203,311,694...203,328,523
JBrowse link
G Dr1 down-regulator of transcription 1 decreases expression ISO Clozapine results in decreased expression of DR1 protein CTD PMID:34122009 NCBI chr14:1,603,203...1,614,556
Ensembl chr14:1,603,204...1,614,556
JBrowse link
G Drd1 dopamine receptor D1 affects binding
decreases expression
affects response to substance
ISO
EXP
Clozapine binds to DRD1 protein
Clozapine results in decreased expression of DRD1 mRNA
Clozapine analog binds to DRD1 protein
DRD1 gene polymorphism affects the susceptibility to Clozapine; DRD1 protein affects the susceptibility to Clozapine
CTD PMID:1352677 PMID:9723970 PMID:11997696 PMID:17092969 PMID:17266109 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects binding
affects response to substance
decreases expression
increases response to substance
ISO
EXP
[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein
Clozapine binds to DRD2 protein
DRD2 protein affects the susceptibility to Clozapine
Clozapine results in decreased expression of DRD2 mRNA
Clozapine analog binds to DRD2 protein; Clozapine binds to DRD2 protein
[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]; Clozapine binds to and results in decreased activity of DRD2 protein; Clozapine promotes the reaction [Dopamine binds to DRD2 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]
[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA
Clozapine binds to DRD2 protein alternative form
DRD2 gene SNP results in increased susceptibility to Clozapine
DRD2 gene affects the susceptibility to Clozapine; DRD2 gene polymorphism affects the susceptibility to Clozapine
CTD PMID:1352677 PMID:9723970 PMID:11997696 PMID:12476322 PMID:15286066 More... NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339
JBrowse link
G Drd3 dopamine receptor D3 affects response to substance
multiple interactions
decreases response to substance
ISO DRD3 protein affects the susceptibility to Clozapine
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
DRD3 gene polymorphism results in decreased susceptibility to Clozapine
CTD PMID:15579174 PMID:20029384 NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760
JBrowse link
G Drd4 dopamine receptor D4 affects binding
multiple interactions
affects response to substance
ISO
EXP
Clozapine binds to DRD4 protein
Clozapine binds to Drd4 protein
Clozapine inhibits the reaction [Dopamine results in increased activity of DRD4 protein]
Clozapine analog binds to DRD4 protein
DRD4 gene polymorphism affects the susceptibility to Clozapine
CTD
RGD
PMID:11997696 PMID:16223700 PMID:31323226 PMID:8078498 RGD:7248459 NCBI chr 1:205,825,937...205,829,124
Ensembl chr 1:205,826,049...205,830,458
JBrowse link
G Drp2 dystrophin related protein 2 increases expression EXP Clozapine results in increased expression of DRP2 mRNA alternative form CTD PMID:16715494 NCBI chr  X:101,900,743...101,951,403
Ensembl chr  X:101,901,011...101,951,403
JBrowse link
G Dtnbp1 dystrobrevin binding protein 1 increases response to substance
affects response to substance
ISO DTNBP1 gene polymorphism results in increased susceptibility to Clozapine
DTNBP1 protein affects the susceptibility to Clozapine
CTD PMID:19369910 NCBI chr17:19,891,313...19,982,770
Ensembl chr17:19,891,337...19,984,418
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression EXP Clozapine results in decreased expression of DUSP1 mRNA CTD PMID:15860345 NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644
JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression EXP Clozapine results in decreased expression of DUSP6 mRNA CTD PMID:15860345 NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833
JBrowse link
G Dvl3 dishevelled segment polarity protein 3 increases expression
multiple interactions
EXP Clozapine results in increased expression of DVL3 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]
CTD PMID:16144542 NCBI chr11:93,869,834...93,887,013
Ensembl chr11:93,869,834...93,886,903
JBrowse link
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 decreases expression ISO Clozapine results in decreased expression of DYNC1LI1 protein CTD PMID:34122009 NCBI chr 8:123,254,823...123,288,496
Ensembl chr 8:123,254,859...123,289,167
JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 decreases expression ISO Clozapine results in decreased expression of DYNC1LI2 protein CTD PMID:34122009 NCBI chr19:538,207...561,110
Ensembl chr19:538,211...561,107
JBrowse link
G Edc4 enhancer of mRNA decapping 4 increases expression ISO Clozapine results in increased expression of EDC4 protein CTD PMID:34122009 NCBI chr19:50,683,924...50,695,916
Ensembl chr19:50,683,897...50,697,620
JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 increases expression ISO Clozapine results in increased expression of EEF1A2 protein CTD PMID:34122009 NCBI chr 3:188,643,455...188,652,633
Ensembl chr 3:188,643,458...188,677,712
JBrowse link
G Eef1d eukaryotic translation elongation factor 1 delta decreases expression ISO Clozapine results in decreased expression of EEF1D protein CTD PMID:34122009 NCBI chr 7:109,462,645...109,478,021
Ensembl chr 7:109,462,646...109,489,531
JBrowse link
G Egr1 early growth response 1 decreases expression EXP Clozapine results in decreased expression of EGR1 mRNA; Clozapine results in decreased expression of EGR1 protein CTD PMID:17028028 PMID:18208916 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843
JBrowse link
G Egr2 early growth response 2 affects expression
decreases expression
ISO
EXP
Clozapine affects the expression of EGR2 mRNA
Clozapine results in decreased expression of EGR2 protein
CTD PMID:17028028 PMID:19401217 NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748
JBrowse link
G Egr3 early growth response 3 affects response to substance ISO EGR3 protein affects the susceptibility to Clozapine CTD PMID:17637609 NCBI chr15:51,560,482...51,565,778
Ensembl chr15:51,560,344...51,565,712
JBrowse link
G Eif2s3 eukaryotic translation initiation factor 2 subunit gamma increases expression ISO Clozapine results in increased expression of EIF2S3 protein CTD PMID:34122009 NCBI chr  X:62,910,292...62,933,936
Ensembl chr  X:62,910,293...62,934,489
JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of EIF3C protein CTD PMID:34122009 NCBI chr 1:190,565,183...190,583,067
Ensembl chr 1:190,565,184...190,583,067
JBrowse link
G Eif3j eukaryotic translation initiation factor 3, subunit J increases expression ISO Clozapine results in increased expression of EIF3J protein CTD PMID:34122009 NCBI chr 3:129,438,715...129,460,953
Ensembl chr 3:129,438,722...129,462,246
JBrowse link
G Eif3m eukaryotic translation initiation factor 3, subunit M multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of EIF3M protein CTD PMID:34122009 NCBI chr 3:111,879,589...111,897,193
Ensembl chr 3:111,870,925...111,897,193
JBrowse link
G Eif4a3 eukaryotic translation initiation factor 4A3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of EIF4A3 protein CTD PMID:34122009 NCBI chr10:105,047,567...105,057,561
Ensembl chr10:105,047,568...105,058,207
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of EIF4E protein CTD PMID:34122009 NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105
JBrowse link
G Eif5b eukaryotic translation initiation factor 5B increases expression ISO Clozapine results in increased expression of EIF5B protein CTD PMID:34122009 NCBI chr 9:47,718,706...47,773,289
Ensembl chr 9:47,718,706...47,778,583
JBrowse link
G Eif6 eukaryotic translation initiation factor 6 decreases expression ISO Clozapine results in decreased expression of EIF6 protein CTD PMID:34122009 NCBI chr 3:164,785,162...164,791,410
Ensembl chr 3:164,785,163...164,791,525
JBrowse link
G Elk1 ETS transcription factor ELK1 decreases phosphorylation ISO Clozapine results in decreased phosphorylation of ELK1 protein CTD PMID:12871586 NCBI chr  X:3,692,367...3,709,252
Ensembl chr  X:3,693,293...3,709,249
JBrowse link
G Eno1 enolase 1 increases expression EXP Clozapine results in increased expression of ENO1 mRNA CTD PMID:15860345 NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003
JBrowse link
G Eno3 enolase 3 increases expression ISO Clozapine results in increased expression of ENO3 protein CTD PMID:34122009 NCBI chr10:55,868,880...55,876,099
Ensembl chr10:55,866,101...55,874,540
JBrowse link
G Epha7 Eph receptor A7 increases expression ISO Clozapine results in increased expression of EPHA7 mRNA CTD PMID:17266109 NCBI chr 5:47,771,776...47,925,189
Ensembl chr 5:47,771,865...47,925,058
JBrowse link
G Ephb3 Eph receptor B3 increases expression ISO Clozapine results in increased expression of EPHB3 protein CTD PMID:34122009 NCBI chr11:93,345,098...93,363,775
Ensembl chr11:93,345,098...93,363,775
JBrowse link
G Erap1 endoplasmic reticulum aminopeptidase 1 decreases expression ISO Clozapine results in decreased expression of ERAP1 protein CTD PMID:34122009 NCBI chr 2:5,666,337...5,705,256
Ensembl chr 2:5,666,436...5,740,056
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects phosphorylation EXP Clozapine affects the phosphorylation of ERBB2 protein CTD PMID:26961615 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions EXP Clozapine results in increased expression of and results in increased phosphorylation of ERBB4 protein CTD PMID:26961615 NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:76,973,227...78,045,772
JBrowse link
G Erh ERH, mRNA splicing and mitosis factor increases expression ISO Clozapine results in increased expression of ERH protein CTD PMID:34122009 NCBI chr 6:106,012,255...106,022,521
Ensembl chr 6:106,012,255...106,022,623
JBrowse link
G Erp44 endoplasmic reticulum protein 44 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of ERP44 protein CTD PMID:34122009 NCBI chr 5:67,313,245...67,406,207
Ensembl chr 5:67,312,098...67,406,444
JBrowse link
G Ewsr1 EWS RNA-binding protein 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of EWSR1 protein CTD PMID:34122009 NCBI chr14:84,179,413...84,208,149
Ensembl chr14:84,179,618...84,208,095
JBrowse link
G Exosc4 exosome component 4 increases expression ISO Clozapine results in increased expression of EXOSC4 protein CTD PMID:34122009 NCBI chr 7:109,928,491...109,931,233
Ensembl chr 7:109,928,498...109,931,820
JBrowse link
G Ezr ezrin decreases expression ISO Clozapine results in decreased expression of EZR protein CTD PMID:34122009 NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Clozapine results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113
JBrowse link
G Fan1 FANCD2 and FANCI associated nuclease 1 increases expression ISO Clozapine results in increased expression of FAN1 protein CTD PMID:34122009 NCBI chr 1:127,327,098...127,356,807
Ensembl chr 1:127,330,016...127,356,400
JBrowse link
G Farsa phenylalanyl-tRNA synthetase subunit alpha increases expression ISO Clozapine results in increased expression of FARSA protein CTD PMID:34122009 NCBI chr19:40,196,255...40,205,830
Ensembl chr19:40,173,716...40,205,823
JBrowse link
G Farsb phenylalanyl-tRNA synthetase subunit beta increases expression ISO Clozapine results in increased expression of FARSB protein CTD PMID:34122009 NCBI chr 9:87,336,321...87,395,546
Ensembl chr 9:87,336,326...87,395,505
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA CTD PMID:20564506 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
JBrowse link
G Faslg Fas ligand multiple interactions ISO [Clozapine analog co-treated with Hydrogen Peroxide] results in increased expression of FASLG mRNA; [Clozapine co-treated with Hydrogen Peroxide co-treated with Tretinoin] results in increased expression of FASLG mRNA CTD PMID:16510162 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503
JBrowse link
G Fasn fatty acid synthase increases expression ISO Clozapine results in increased expression of FASN mRNA CTD PMID:16027736 PMID:17052361 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression ISO Clozapine results in increased expression of FDPS mRNA CTD PMID:17052361 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136
JBrowse link
G Fen1 flap structure-specific endonuclease 1 increases expression ISO Clozapine results in increased expression of FEN1 protein CTD PMID:34122009 NCBI chr 1:216,270,016...216,274,873
Ensembl chr 1:216,269,163...216,275,016
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression EXP Clozapine results in increased expression of FGF2 mRNA CTD PMID:11264663 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493
JBrowse link
G Fgl1 fibrinogen-like 1 increases expression ISO Clozapine results in increased expression of FGL1 protein CTD PMID:36482696 NCBI chr16:57,824,127...57,854,413
Ensembl chr16:57,824,200...57,854,429
JBrowse link
G Fhod1 formin homology 2 domain containing 1 decreases expression ISO Clozapine results in decreased expression of FHOD1 protein CTD PMID:34122009 NCBI chr19:50,116,415...50,135,868
Ensembl chr19:50,116,415...50,135,330
JBrowse link
G Fkbp8 FKBP prolyl isomerase 8 decreases expression ISO Clozapine results in decreased expression of FKBP8 protein CTD PMID:34122009 NCBI chr16:18,929,581...18,936,621
Ensembl chr16:18,929,582...18,936,543
JBrowse link
G Flot2 flotillin 2 increases expression ISO Clozapine results in increased expression of FLOT2 protein CTD PMID:34122009 NCBI chr10:63,424,084...63,445,811
Ensembl chr10:63,423,806...63,445,810
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases metabolic processing ISO FMO1 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of Clozapine CTD PMID:18809730 PMID:27320963 NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256
JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Clozapine results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:30,797,102...30,800,782
Ensembl chr 6:30,796,871...30,800,769
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases expression
EXP
ISO
Clozapine affects the reaction [Haloperidol results in increased expression of FOS protein]; Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA]
Clozapine results in increased expression of FOS protein
Clozapine analog results in increased expression of FOS protein; Clozapine results in increased expression of FOS mRNA; Clozapine results in increased expression of FOS protein
Clozapine results in decreased expression of FOS protein
CTD PMID:10435392 PMID:11166331 PMID:11440804 PMID:11997696 PMID:12093589 More... NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
decreases expression
ISO
EXP
Clozapine results in increased expression of FOSB protein alternative form
Clozapine results in increased expression of FOSB mRNA; Clozapine results in increased expression of FOSB protein
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
Clozapine results in decreased expression of FOSB mRNA
CTD PMID:11259127 PMID:12093589 PMID:12243769 PMID:15579174 PMID:19695244 NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression EXP Clozapine results in increased expression of FOSL1 mRNA CTD PMID:18208916 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression EXP Clozapine results in increased expression of FOSL2 mRNA CTD PMID:12093589 PMID:12243769 NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406
JBrowse link
G Foxp2 forkhead box P2 increases expression ISO Clozapine results in increased expression of FOXP2 mRNA CTD PMID:17266109 NCBI chr 4:44,099,848...44,677,700
Ensembl chr 4:44,099,959...44,677,696
JBrowse link
G Fstl1 follistatin-like 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of FSTL1 protein CTD PMID:34122009 NCBI chr11:76,400,870...76,454,053
Ensembl chr11:76,391,315...76,455,126
JBrowse link
G Fubp1 far upstream element binding protein 1 increases expression ISO Clozapine results in increased expression of FUBP1 protein CTD PMID:34122009 NCBI chr 2:243,819,529...243,846,544
Ensembl chr 2:243,819,218...243,846,428
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases expression ISO Clozapine results in decreased expression of G6PD protein CTD PMID:34122009 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144
JBrowse link
G Gabarapl2 GABA type A receptor associated protein like 2 increases expression ISO Clozapine results in increased expression of GABARAPL2 protein CTD PMID:36482696 NCBI chr19:56,819,826...56,830,662
Ensembl chr19:56,819,791...56,830,660
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 decreases expression ISO Clozapine results in decreased expression of GABBR1 mRNA CTD PMID:17266109 NCBI chr20:1,469,779...1,499,352
Ensembl chr20:1,469,779...1,498,607
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases expression ISO Clozapine results in increased expression of GABRA1 mRNA CTD PMID:17266109 NCBI chr10:27,096,731...27,152,563
Ensembl chr10:27,096,740...27,152,442
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases expression EXP Clozapine results in increased expression of GABRB3 mRNA CTD PMID:18923069 NCBI chr 1:117,602,772...117,838,230
Ensembl chr 1:117,431,842...117,836,725
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression
decreases methylation
multiple interactions
ISO
EXP
Clozapine results in increased expression of GAD1 mRNA
Clozapine results in decreased methylation of GAD1 promoter
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]; Valproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter]
CTD PMID:12887421 PMID:15061247 PMID:17942719 PMID:18757738 PMID:18923069 NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759
JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression ISO
EXP
Clozapine results in increased expression of GAD2 mRNA CTD PMID:17266109 PMID:18923069 NCBI chr17:89,671,718...89,734,246
Ensembl chr17:89,671,716...89,941,089
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression EXP
ISO
Clozapine results in increased expression of GAPDH mRNA
Clozapine results in increased expression of GAPDH protein
CTD PMID:15860345 PMID:34122009 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377
JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase increases expression ISO Clozapine results in increased expression of GART protein CTD PMID:34122009 NCBI chr11:44,351,841...44,377,086
Ensembl chr11:44,351,851...44,377,086
JBrowse link
G Gatm glycine amidinotransferase increases expression ISO Clozapine results in increased expression of GATM protein CTD PMID:34122009 NCBI chr 3:130,112,508...130,137,664
Ensembl chr 3:130,112,509...130,129,355
JBrowse link
G Gcc2 GRIP and coiled-coil domain containing 2 decreases expression ISO Clozapine results in decreased expression of GCC2 protein CTD PMID:34122009 NCBI chr20:26,788,472...26,836,728
Ensembl chr20:26,790,516...26,836,726
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Clozapine results in increased expression of GDF15 protein CTD PMID:36482696 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Clozapine results in increased expression of GDPD3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:190,804,053...190,813,609
Ensembl chr 1:190,803,993...190,813,606
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression
EXP Clozapine results in decreased expression of GFAP protein
Clozapine results in increased expression of GFAP mRNA
CTD PMID:18585900 PMID:19441803 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
JBrowse link
G Ghitm growth hormone inducible transmembrane protein increases expression ISO Clozapine results in increased expression of GHITM protein CTD PMID:34122009 NCBI chr16:12,907,062...12,918,149
Ensembl chr16:12,905,806...12,918,123
JBrowse link
G Gimap5 GTPase, IMAP family member 5 decreases expression EXP Clozapine results in decreased expression of GIMAP5 mRNA CTD PMID:16715494 NCBI chr 4:79,025,151...79,031,917
Ensembl chr 4:79,024,304...79,039,030
JBrowse link
G Gip gastric inhibitory polypeptide increases expression EXP Clozapine results in increased expression of GIP mRNA; Clozapine results in increased expression of GIP protein CTD PMID:16402076 NCBI chr10:81,465,070...81,473,216
Ensembl chr10:81,465,062...81,473,216
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP Clozapine results in increased expression of GJA1 protein CTD PMID:18585900 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689
JBrowse link
G Glp1r glucagon-like peptide 1 receptor multiple interactions
decreases expression
EXP PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein] CTD PMID:37087062 NCBI chr20:8,973,393...9,011,622
Ensembl chr20:8,973,352...9,011,654
JBrowse link
G Glrx3 glutaredoxin 3 increases expression ISO Clozapine results in increased expression of GLRX3 protein CTD PMID:34122009 NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:201,671,481...201,701,717
JBrowse link
G Glul glutamate-ammonia ligase decreases expression ISO Clozapine results in decreased expression of GLUL protein CTD PMID:36482696 NCBI chr13:68,519,500...68,585,554
Ensembl chr13:68,576,067...68,585,520
JBrowse link
G Gna12 G protein subunit alpha 12 decreases expression
increases expression
EXP
ISO
Clozapine results in decreased expression of GNA12 mRNA
Clozapine results in increased expression of GNA12 protein
CTD PMID:15860345 PMID:34122009 NCBI chr12:18,919,629...19,000,185
Ensembl chr12:18,919,629...19,000,185
JBrowse link
G Gnai1 G protein subunit alpha i1 decreases expression EXP Clozapine results in decreased expression of GNAI1 mRNA CTD PMID:15860345 NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:17,706,025...17,789,198
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP Clozapine results in decreased expression of GNAI2 mRNA CTD PMID:15860345 NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622
JBrowse link
G Gnai3 G protein subunit alpha i3 decreases expression EXP Clozapine results in decreased expression of GNAI3 mRNA CTD PMID:15860345 NCBI chr 2:198,430,920...198,468,874 JBrowse link
G Gnas GNAS complex locus decreases expression
multiple interactions
increases expression
EXP
ISO
Clozapine results in decreased expression of GNAS mRNA
[Cuprizone co-treated with Clozapine] results in decreased expression of GNAS protein
Clozapine results in increased expression of GNAS protein
CTD PMID:15860345 PMID:34122009 NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:183,503,243...183,554,536
JBrowse link
G Gnb3 G protein subunit beta 3 decreases response to substance
increases expression
affects response to substance
increases response to substance
ISO
EXP
GNB3 gene polymorphism results in decreased susceptibility to Clozapine
Clozapine results in increased expression of GNB3 protein
GNB3 protein affects the susceptibility to Clozapine
GNB3 gene polymorphism results in increased susceptibility to Clozapine
CTD PMID:16139171 PMID:16141801 PMID:18855531 NCBI chr 4:159,325,741...159,331,443
Ensembl chr 4:159,325,742...159,331,445
JBrowse link
G Golga3 golgin A3 increases expression ISO Clozapine results in increased expression of GOLGA3 protein CTD PMID:34122009 NCBI chr12:52,112,129...52,160,311
Ensembl chr12:52,114,590...52,160,226
JBrowse link
G Golgb1 golgin B1 increases expression ISO Clozapine results in increased expression of GOLGB1 protein CTD PMID:34122009 NCBI chr11:77,348,573...77,406,165
Ensembl chr11:77,348,961...77,406,006
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression
multiple interactions
EXP
ISO
Clozapine results in increased expression of GOT2 mRNA
[Cuprizone co-treated with Clozapine] results in increased expression of GOT2 protein
CTD PMID:15860345 PMID:34122009 NCBI chr19:9,180,428...9,206,113
Ensembl chr19:9,180,431...9,206,111
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 decreases expression ISO Clozapine results in decreased expression of GPD2 protein CTD PMID:34122009 NCBI chr 3:62,209,432...62,346,590
Ensembl chr 3:62,210,814...62,346,593
JBrowse link
G Gpi glucose-6-phosphate isomerase increases expression ISO Clozapine results in increased expression of GPI protein CTD PMID:34122009 NCBI chr 1:95,965,389...95,996,932
Ensembl chr 1:95,965,396...95,993,261
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Chloroquine co-treated with Clozapine] results in increased secretion of GPT protein CTD PMID:36482696 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Clozapine results in increased expression of GPX1 mRNA CTD PMID:14647396 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 increases expression EXP Clozapine results in increased expression of GRIK2 mRNA CTD PMID:18923069 NCBI chr20:53,717,564...54,415,283
Ensembl chr20:53,716,090...54,415,202
JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 affects expression
decreases expression
ISO
EXP
Clozapine affects the expression of GRIK5 mRNA
Clozapine results in decreased expression of GRIK5 mRNA
CTD PMID:14647396 PMID:18923069 NCBI chr 1:89,733,736...89,795,769
Ensembl chr 1:89,733,741...89,794,962
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression
increases expression
ISO
EXP
Clozapine results in decreased expression of GRIN1 mRNA
Clozapine results in increased expression of GRIN1 mRNA
CTD PMID:12020038 PMID:12608697 PMID:17266109 PMID:18923069 NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression EXP Clozapine results in decreased expression of GRIN2A mRNA CTD PMID:12608697 PMID:18923069 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression EXP Clozapine results in decreased expression of GRIN2B mRNA CTD PMID:18923069 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C decreases expression EXP Clozapine results in decreased expression of GRIN2C mRNA CTD PMID:18923069 NCBI chr10:100,987,410...101,006,064
Ensembl chr10:100,987,513...101,005,409
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 decreases expression EXP Clozapine results in decreased expression of GRK6 mRNA CTD PMID:16715494 NCBI chr17:9,182,160...9,198,380
Ensembl chr17:9,182,160...9,197,954
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases expression
multiple interactions
EXP Clozapine results in increased expression of GSK3A protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]
CTD PMID:16144542 NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:89,943,669...89,953,593
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
increases expression
multiple interactions
ISO
EXP
Clozapine results in increased phosphorylation of GSK3B protein
Clozapine results in increased expression of GSK3B protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]
CTD PMID:16144542 PMID:19359144 PMID:19440698 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity
increases glutathionylation
ISO GSTA1 protein results in decreased activity of Clozapine
GSTA1 protein results in increased glutathionylation of Clozapine
CTD PMID:20849150 NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity
increases expression
increases glutathionylation
ISO
EXP
GSTM1 protein results in decreased activity of Clozapine
Clozapine results in increased expression of GSTM1 mRNA
GSTM1 protein results in increased glutathionylation of Clozapine
CTD PMID:15860345 PMID:20849150 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Clozapine results in decreased expression of GSTM2 mRNA CTD PMID:15860345 NCBI chr 2:198,312,179...198,316,962 JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity
affects metabolic processing
increases glutathionylation
affects binding
ISO Clozapine metabolite results in decreased activity of GSTP1 protein; GSTP1 protein results in decreased activity of Clozapine
GSTP1 protein affects the metabolism of Clozapine metabolite
GSTP1 protein results in increased glutathionylation of Clozapine
Clozapine metabolite binds to GSTP1 protein
CTD PMID:20849150 PMID:21639118 PMID:24185126 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705
JBrowse link
G H1f2 H1.2 linker histone, cluster member increases expression ISO Clozapine results in increased expression of H1-2 protein CTD PMID:34122009 NCBI chr17:41,818,962...41,820,453
Ensembl chr17:41,779,051...41,822,317
JBrowse link
G H2ac18 H2A clustered histone 18 increases expression ISO Clozapine results in increased expression of H2AC18 mRNA CTD PMID:14647396 NCBI chr 2:186,497,271...186,497,865 JBrowse link
G H2ac20 H2A clustered histone 20 increases expression ISO Clozapine results in increased expression of H2AC20 protein CTD PMID:34122009 NCBI chr 2:186,468,748...186,469,226 JBrowse link
G H2aj H2A.J histone increases expression ISO Clozapine results in increased expression of H2AJ protein CTD PMID:34122009 NCBI chr 4:171,406,922...171,407,406
Ensembl chr 4:171,406,177...171,408,845
JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase decreases expression ISO Clozapine results in decreased expression of HAAO protein CTD PMID:36482696 NCBI chr 6:16,598,325...16,617,590
Ensembl chr 6:16,598,087...16,617,356
JBrowse link
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 increases expression ISO Clozapine results in increased expression of HACD3 protein CTD PMID:34122009 NCBI chr 8:74,396,441...74,433,700
Ensembl chr 8:74,396,442...74,433,700
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression ISO Clozapine results in increased expression of HADHB protein CTD PMID:34122009 NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:31,873,404...31,907,835
JBrowse link
G Hars1 histidyl-tRNA synthetase 1 increases expression ISO Clozapine results in increased expression of HARS1 protein CTD PMID:34122009 NCBI chr18:28,655,669...28,672,712
Ensembl chr18:28,655,671...28,672,712
JBrowse link
G Hat1 histone acetyltransferase 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of HAT1 protein CTD PMID:34122009 NCBI chr 3:76,624,442...76,672,701
Ensembl chr 3:76,624,869...76,672,696
JBrowse link
G Hcls1 hematopoietic cell specific Lyn substrate 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of HCLS1 protein CTD PMID:34122009 NCBI chr11:77,322,873...77,346,333
Ensembl chr11:77,322,873...77,346,387
JBrowse link
G Hdgfl2 HDGF like 2 increases expression ISO Clozapine results in increased expression of HDGFRP2 protein CTD PMID:34122009 NCBI chr 9:996,687...1,016,352
Ensembl chr 9:996,758...1,016,735
JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A increases expression ISO Clozapine results in increased expression of HIGD1A mRNA CTD PMID:14647396 NCBI chr 8:130,391,658...130,400,888
Ensembl chr 8:130,391,661...130,400,888
JBrowse link
G Hmgb2 high mobility group box 2 increases expression ISO Clozapine results in increased expression of HMGB2 protein CTD PMID:34122009 NCBI chr16:37,721,374...37,723,950
Ensembl chr16:37,721,379...37,723,860
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
increases activity
ISO [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides
Clozapine results in increased expression of HMGCR mRNA
CTD PMID:16027736 PMID:17052361 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Clozapine results in increased expression of HMGCS1 mRNA CTD PMID:16027736 PMID:17052361 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Clozapine results in increased expression of HMOX1 mRNA CTD PMID:18227147 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D decreases expression ISO Clozapine results in decreased expression of HNRNPD protein CTD PMID:34122009 NCBI chr14:9,918,630...9,938,072
Ensembl chr14:9,919,739...9,938,066
JBrowse link
G Hnrnph2 heterogeneous nuclear ribonucleoprotein H2 decreases expression ISO Clozapine results in decreased expression of HNRNPH2 protein CTD PMID:36482696 NCBI chr  X:102,074,175...102,080,115
Ensembl chr  X:102,074,179...102,081,025
JBrowse link
G Homer1 homer scaffold protein 1 increases expression
multiple interactions
EXP Clozapine results in increased expression of HOMER1 mRNA
Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]
CTD PMID:12464447 PMID:15860345 NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:26,278,105...26,381,657
JBrowse link
G Hpcal1 hippocalcin-like 1 decreases expression EXP Clozapine results in decreased expression of HPCAL1 mRNA CTD PMID:12437575 NCBI chr 6:46,206,809...46,313,364
Ensembl chr 6:46,260,494...46,313,353
JBrowse link
G Hpcal4 hippocalcin-like 4 affects expression EXP Clozapine affects the expression of HPCAL4 mRNA CTD PMID:12437575 NCBI chr 5:140,739,577...140,751,529
Ensembl chr 5:140,739,635...140,751,530
JBrowse link
G Hpn hepsin increases expression ISO Clozapine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:95,464,468...95,480,169
Ensembl chr 1:95,464,470...95,480,199
JBrowse link
G Hrh1 histamine receptor H 1 affects binding ISO Clozapine binds to HRH1 protein CTD PMID:16983399 NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248
JBrowse link
G Hrh3 histamine receptor H3 multiple interactions EXP Clozapine binds to Hrh3 protein; Clozapine inhibits the reaction [N-methylhistamine binds to Hrh3 protein] RGD PMID:10869375 RGD:632981 NCBI chr 3:187,569,174...187,575,263
Ensembl chr 3:187,569,175...187,574,259
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression ISO Clozapine results in decreased expression of HSD17B10 protein CTD PMID:34122009 NCBI chr  X:24,568,551...24,571,012
Ensembl chr  X:24,568,551...24,574,681
JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 increases expression ISO Clozapine results in increased expression of HSD17B12 protein CTD PMID:34122009 NCBI chr 3:100,445,393...100,568,898
Ensembl chr 3:100,445,400...100,568,938
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 decreases expression ISO Clozapine results in decreased expression of HSPA9 protein CTD PMID:34122009 NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
affects binding
ISO
EXP
Clozapine binds to and affects the activity of HTR1A protein
Clozapine binds to HTR1A protein
CTD PMID:9723970 PMID:15482641 NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760
JBrowse link
G Htr1d 5-hydroxytryptamine receptor 1D decreases expression EXP Clozapine results in decreased expression of HTR1D mRNA CTD PMID:16715494 NCBI chr 5:153,939,735...153,960,012
Ensembl chr 5:153,939,516...153,960,012
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases response to substance
affects binding
multiple interactions
decreases expression
decreases activity
affects response to substance
increases expression
ISO
EXP
HTR2A gene SNP results in increased susceptibility to Clozapine
Clozapine analog binds to HTR2A protein; Clozapine binds to HTR2A protein
Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein]
Clozapine results in decreased expression of HTR2A mRNA; Clozapine results in decreased expression of HTR2A protein
Clozapine results in decreased activity of HTR2A protein
[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]; Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein]
HTR2A protein affects the susceptibility to Clozapine
Clozapine results in increased expression of HTR2A mRNA
CTD PMID:7520908 PMID:9723970 PMID:11997696 PMID:14751426 PMID:15380371 More... NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding
decreases expression
affects response to substance
ISO
EXP
Clozapine binds to HTR2C protein
Clozapine results in decreased expression of HTR2C mRNA
HTR2C gene polymorphism affects the susceptibility to Clozapine; HTR2C gene SNP affects the susceptibility to Clozapine; HTR2C promoter SNP affects the susceptibility to Clozapine; HTR2C protein affects the susceptibility to Clozapine
CTD PMID:9723970 PMID:12668355 PMID:15635667 PMID:16983399 PMID:17868938 More... NCBI chr  X:115,453,190...115,682,325
Ensembl chr  X:115,452,842...115,682,324
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions
affects response to substance
ISO Clozapine binds to and results in decreased activity of HTR3A protein
HTR3A protein affects the susceptibility to Clozapine
CTD PMID:19696922 PMID:20168265 NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 multiple interactions
affects binding
ISO Clozapine binds to and results in decreased activity of HTR6 protein
[Cuprizone co-treated with Clozapine] results in increased expression of HTR6 protein
Clozapine binds to HTR6 protein
CTD PMID:11406289 PMID:16983399 PMID:34122009 NCBI chr 5:156,579,901...156,595,147
Ensembl chr 5:156,579,901...156,595,147
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 affects binding
multiple interactions
ISO Clozapine binds to HTR7 protein
[Clozapine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Clozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]
CTD PMID:14578406 PMID:20827463 NCBI chr 1:243,049,064...243,173,636
Ensembl chr 1:243,049,081...243,173,230
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression EXP Clozapine results in increased expression of ID2 mRNA CTD PMID:12437575 NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of IDH2 protein CTD PMID:34122009 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO Clozapine results in decreased expression of IDI1 protein CTD PMID:34122009 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524
JBrowse link
G Ifng interferon gamma affects expression
decreases expression
ISO Clozapine affects the expression of IFNG protein
Clozapine results in decreased expression of IFNG mRNA
CTD PMID:17346280 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Ifngr1 interferon gamma receptor 1 increases expression ISO Clozapine results in increased expression of IFNGR1 protein CTD PMID:36482696 NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:16,152,879...16,171,437
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO Clozapine results in decreased expression of IGF1 protein CTD PMID:11769361 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO Clozapine results in increased expression of IGFBP1 protein CTD PMID:36482696 NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344
JBrowse link
G Il10 interleukin 10 decreases expression EXP Clozapine results in decreased expression of IL10 protein CTD PMID:24709159 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions
EXP Clozapine results in increased secretion of IL1B protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of IL1B protein]
CTD PMID:34935985 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases secretion ISO Clozapine results in increased secretion of IL2RA protein CTD PMID:8067274 NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507
JBrowse link
G Il5 interleukin 5 affects expression ISO Clozapine affects the expression of IL5 protein CTD PMID:17346280 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003
JBrowse link
G Ilkap ILK associated serine/threonine phosphatase decreases expression EXP Clozapine results in decreased expression of ILKAP mRNA CTD PMID:15860345 NCBI chr 9:99,413,981...99,436,262
Ensembl chr 9:99,413,978...99,436,418
JBrowse link
G Inha inhibin subunit alpha decreases expression EXP Clozapine results in decreased expression of INHA mRNA CTD PMID:16715494 NCBI chr 9:84,443,109...84,446,010
Ensembl chr 9:84,443,109...84,446,009
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Clozapine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519
JBrowse link
G Ins2 insulin 2 affects secretion
increases expression
ISO Clozapine affects the secretion of INS protein
Clozapine results in increased expression of INS protein
CTD PMID:11769361 PMID:16601995 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805
JBrowse link
G Itga6 integrin subunit alpha 6 increases expression ISO Clozapine results in increased expression of ITGA6 protein CTD PMID:34122009 NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:77,017,766...77,097,076
JBrowse link
G Jak1 Janus kinase 1 increases expression ISO Clozapine results in increased expression of JAK1 protein CTD PMID:36482696 NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP [[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein] CTD PMID:18976543 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
increases expression
EXP Clozapine results in decreased expression of JUN mRNA
Clozapine results in increased expression of JUN mRNA
CTD PMID:12093589 PMID:15860345 PMID:18208916 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Clozapine results in increased expression of JUNB mRNA CTD PMID:12093589 PMID:19695244 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Clozapine results in decreased expression of JUND mRNA CTD PMID:12093589 NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148
JBrowse link
G Kcna1 potassium voltage-gated channel subfamily A member 1 increases expression ISO Clozapine results in increased expression of KCNA1 mRNA CTD PMID:18797397 NCBI chr 4:161,150,378...161,160,051
Ensembl chr 4:161,147,418...161,160,044
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Clozapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421
JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 decreases expression
increases expression
ISO Clozapine results in decreased expression of KCNIP3 mRNA
Clozapine results in increased expression of KCNIP3 mRNA
CTD PMID:17266109 PMID:18797397 NCBI chr 3:135,130,331...135,196,031
Ensembl chr 3:135,132,119...135,196,216
JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 decreases expression ISO Clozapine results in decreased expression of KCNK2 mRNA CTD PMID:15542763 NCBI chr13:103,297,387...103,494,686
Ensembl chr13:103,297,393...103,494,686
JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 decreases expression ISO Clozapine results in decreased expression of KCTD12 protein CTD PMID:34122009 NCBI chr15:86,214,786...86,220,725
Ensembl chr15:86,214,840...86,224,539
JBrowse link
G Kdr kinase insert domain receptor increases expression ISO Clozapine results in increased expression of KDR protein CTD PMID:34122009 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192
JBrowse link
G Khdrbs1 KH RNA binding domain containing, signal transduction associated 1 decreases expression ISO Clozapine results in decreased expression of KHDRBS1 protein CTD PMID:34122009 NCBI chr 5:147,337,048...147,374,604
Ensembl chr 5:147,347,904...147,373,448
JBrowse link
G Kif13b kinesin family member 13B increases expression ISO Clozapine results in increased expression of KIF13B protein CTD PMID:34122009 NCBI chr15:43,084,059...43,241,719
Ensembl chr15:43,080,910...43,241,719
JBrowse link
G Kif5c kinesin family member 5C decreases expression ISO Clozapine results in decreased expression of KIF5C protein CTD PMID:34122009 NCBI chr 3:54,441,266...54,591,630
Ensembl chr 3:54,441,310...54,594,813
JBrowse link
G Kiz kizuna centrosomal protein multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of KIZ protein CTD PMID:34122009 NCBI chr 3:154,730,873...154,838,410
Ensembl chr 3:154,730,634...154,838,410
JBrowse link
G Klhdc2 kelch domain containing 2 decreases expression ISO Clozapine results in decreased expression of KLHDC2 protein CTD PMID:34122009 NCBI chr 6:93,512,981...93,552,809
Ensembl chr 6:93,513,017...93,577,762
JBrowse link
G Kmt2a lysine methyltransferase 2A increases expression
decreases expression
multiple interactions
ISO Clozapine results in increased expression of KMT2A mRNA
Clozapine results in decreased expression of KMT2A mRNA
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]
CTD PMID:14647396 PMID:17942719 NCBI chr 8:54,013,547...54,089,219
Ensembl chr 8:54,013,547...54,089,317
JBrowse link
G Kpna4 karyopherin subunit alpha 4 multiple interactions
increases expression
ISO [Cuprizone co-treated with Clozapine] results in increased expression of KPNA4 protein
Clozapine results in increased expression of KPNA4 protein
CTD PMID:34122009 NCBI chr 2:155,635,679...155,691,056
Ensembl chr 2:155,634,247...155,691,053
JBrowse link
G Kremen1 kringle containing transmembrane protein 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of KREMEN1 protein CTD PMID:34122009 NCBI chr14:84,295,931...84,361,534
Ensembl chr14:84,297,700...84,361,614
JBrowse link
G Lactb2 lactamase, beta 2 increases expression ISO Clozapine results in increased expression of LACTB2 protein CTD PMID:34122009 NCBI chr 5:10,352,165...10,374,928
Ensembl chr 5:10,352,154...10,379,255
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 increases expression ISO Clozapine results in increased expression of LAMP1 protein CTD PMID:34122009 NCBI chr16:83,058,131...83,082,843
Ensembl chr16:83,058,385...83,075,159
JBrowse link
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 increases expression ISO Clozapine results in increased expression of LAMTOR3 mRNA CTD PMID:14647396 NCBI chr 2:229,084,795...229,097,028
Ensembl chr 2:229,084,858...229,099,383
JBrowse link
G Larp7 La ribonucleoprotein 7, transcriptional regulator increases expression ISO Clozapine results in increased expression of LARP7 protein CTD PMID:34122009 NCBI chr 2:218,672,145...218,687,332
Ensembl chr 2:218,672,208...218,687,308
JBrowse link
G Lcn1 lipocalin 1 decreases expression ISO Clozapine results in decreased expression of LCN1 protein CTD PMID:34122009 NCBI chr 3:29,930,943...29,935,418 JBrowse link
G Ldhb lactate dehydrogenase B increases expression EXP Clozapine results in increased expression of LDHB mRNA CTD PMID:15860345 NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:177,159,392...177,177,408
JBrowse link
G Ldlr low density lipoprotein receptor increases expression
multiple interactions
ISO Clozapine results in increased expression of LDLR mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]
CTD PMID:17052361 PMID:20564506 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675
JBrowse link
G Leap2 liver enriched antimicrobial peptide 2 increases expression ISO Clozapine results in increased expression of LEAP2 mRNA CTD PMID:17346280 NCBI chr10:38,081,001...38,082,073
Ensembl chr10:38,081,001...38,082,073
JBrowse link
G Lemd2 LEM domain nuclear envelope protein 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of LEMD2 protein CTD PMID:34122009 NCBI chr20:5,284,275...5,298,281
Ensembl chr20:5,284,275...5,298,328
JBrowse link
G Lep leptin affects response to substance
increases expression
ISO
EXP
LEP protein affects the susceptibility to Clozapine
Clozapine results in increased expression of LEP protein
CTD PMID:16402076 PMID:17502770 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
JBrowse link
G Lgals8 galectin 8 increases expression ISO Clozapine results in increased expression of LGALS8 protein CTD PMID:36482696 NCBI chr17:62,716,368...62,744,272
Ensembl chr17:62,719,828...62,744,482
JBrowse link
G Lipa lipase A, lysosomal acid type increases expression ISO Clozapine results in increased expression of LIPA protein CTD PMID:34122009 NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:241,437,524...241,470,740
JBrowse link
G Lmod2 leiomodin 2 increases expression ISO Clozapine results in increased expression of LMOD2 protein CTD PMID:34122009 NCBI chr 4:54,032,974...54,040,670
Ensembl chr 4:54,032,974...54,040,666
JBrowse link
G Lpl lipoprotein lipase decreases expression
increases expression
ISO Clozapine results in decreased expression of LPL mRNA; Clozapine results in decreased expression of LPL protein
Clozapine results in increased expression of LPL mRNA
CTD PMID:17266109 PMID:19682446 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107
JBrowse link
G Lrp10 LDL receptor related protein 10 increases expression ISO Clozapine results in increased expression of LRP10 protein CTD PMID:36482696 NCBI chr15:31,891,358...31,897,530
Ensembl chr15:31,891,362...31,897,528
JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing increases expression ISO Clozapine results in increased expression of LRPPRC protein CTD PMID:34122009 NCBI chr 6:15,612,638...15,695,113
Ensembl chr 6:15,612,655...15,695,116
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 increases expression ISO Clozapine results in increased expression of LRRK2 protein CTD PMID:34122009 NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:124,706,080...124,867,239
JBrowse link
G Lss lanosterol synthase increases expression
multiple interactions
ISO Clozapine results in increased expression of LSS mRNA
[Cuprizone co-treated with Clozapine] results in decreased expression of LSS protein
CTD PMID:15342952 PMID:17175557 PMID:34122009 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253
JBrowse link
G Lta4h leukotriene A4 hydrolase decreases expression ISO Clozapine results in decreased expression of LTA4H protein CTD PMID:34122009 NCBI chr 7:29,856,846...29,888,642
Ensembl chr 7:29,856,802...29,888,641
JBrowse link
G Magt1 magnesium transporter 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MAGT1 protein CTD PMID:34122009 NCBI chr  X:75,104,040...75,145,247
Ensembl chr  X:75,106,172...75,145,365
JBrowse link
G Mal mal, T-cell differentiation protein decreases expression ISO Clozapine results in decreased expression of MAL mRNA CTD PMID:17266109 PMID:18797397 NCBI chr 3:135,317,664...135,341,423
Ensembl chr 3:135,317,664...135,341,423
JBrowse link
G Maob monoamine oxidase B increases expression ISO Clozapine results in increased expression of MAOB mRNA CTD PMID:17266109 NCBI chr  X:8,490,405...8,594,065
Ensembl chr  X:8,490,344...8,594,375
JBrowse link
G Map1a microtubule-associated protein 1A increases expression
decreases expression
EXP
ISO
Clozapine results in increased expression of MAP1A mRNA
Clozapine results in decreased expression of MAP1A protein
CTD PMID:15860345 PMID:34122009 NCBI chr 3:128,716,907...128,736,638
Ensembl chr 3:128,716,940...128,740,159
JBrowse link
G Map1b microtubule-associated protein 1B decreases expression ISO Clozapine results in decreased expression of MAP1B protein CTD PMID:34122009 NCBI chr 2:32,551,423...32,644,471
Ensembl chr 2:32,551,423...32,657,094
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases lipidation
multiple interactions
ISO Clozapine results in increased lipidation of MAP1LC3B protein
[Chloroquine co-treated with Clozapine] results in increased lipidation of MAP1LC3B protein
CTD PMID:36482696 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358
JBrowse link
G Map1s microtubule-associated protein 1S increases expression ISO Clozapine results in increased expression of MAP1S protein CTD PMID:34122009 NCBI chr16:18,551,573...18,561,760
Ensembl chr16:18,551,573...18,562,141
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases expression EXP Clozapine results in decreased expression of MAP2K1 mRNA CTD PMID:15860345 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases expression
decreases expression
ISO
EXP
Clozapine results in increased expression of MAP2K2 mRNA
Clozapine results in decreased expression of MAP2K2 mRNA
CTD PMID:14647396 PMID:15860345 NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940
JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 decreases expression EXP Clozapine results in decreased expression of MAP2K5 mRNA CTD PMID:15860345 NCBI chr 8:72,520,616...72,748,395
Ensembl chr 8:72,520,617...72,747,373
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression EXP Clozapine results in increased expression of MAP3K1 mRNA CTD PMID:15860345 NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897
JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 increases expression EXP Clozapine results in increased expression of MAP3K12 mRNA CTD PMID:15860345 NCBI chr 7:135,507,082...135,527,396
Ensembl chr 7:135,508,790...135,515,137
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases expression
decreases phosphorylation
ISO
EXP
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]
Clozapine results in decreased expression of MAPK1 mRNA
Clozapine results in decreased phosphorylation of MAPK1 protein
CTD PMID:12871586 PMID:15860345 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects expression EXP Clozapine affects the expression of MAPK14 mRNA CTD PMID:15860345 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO Clozapine results in decreased phosphorylation of MAPK3 protein
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]
CTD PMID:12871586 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mapk6 mitogen-activated protein kinase 6 affects expression EXP Clozapine affects the expression of MAPK6 mRNA CTD PMID:15860345 NCBI chr 8:85,027,141...85,050,236
Ensembl chr 8:85,027,144...85,050,236
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 increases expression ISO Clozapine results in increased expression of MAPK8IP1 mRNA CTD PMID:17266109 NCBI chr 3:98,810,540...98,829,302
Ensembl chr 3:98,810,541...98,828,368
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 affects expression EXP Clozapine affects the expression of MAPK9 mRNA CTD PMID:15860345 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228
JBrowse link
G Mapre1 microtubule-associated protein, RP/EB family, member 1 decreases expression
multiple interactions
ISO Clozapine results in decreased expression of MAPRE1 protein
[Cuprizone co-treated with Clozapine] results in decreased expression of MAPRE1 protein
CTD PMID:34122009 NCBI chr 3:162,679,020...162,707,167
Ensembl chr 3:162,673,195...162,711,210
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor decreases expression EXP Clozapine results in decreased expression of MAS1 mRNA CTD PMID:16715494 NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:50,425,257...50,500,561
JBrowse link
G Mat2a methionine adenosyltransferase 2A decreases expression ISO Clozapine results in decreased expression of MAT2A protein CTD PMID:34122009 NCBI chr 4:106,048,043...106,053,612
Ensembl chr 4:106,038,254...106,053,645
JBrowse link
G Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit decreases expression ISO Clozapine results in decreased expression of MAT2B protein CTD PMID:34122009 NCBI chr10:25,609,202...25,626,694
Ensembl chr10:25,609,204...25,625,176
JBrowse link
G Mbp myelin basic protein increases expression ISO Clozapine results in increased expression of MBP mRNA CTD PMID:17266109 PMID:17346280 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174
JBrowse link
G Mc1r melanocortin 1 receptor increases expression ISO Clozapine results in increased expression of MC1R mRNA CTD PMID:17346280 NCBI chr19:68,360,950...68,363,877
Ensembl chr19:68,360,950...68,363,877
JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MDC1 protein CTD PMID:34122009 NCBI chr20:2,898,496...2,914,960
Ensembl chr20:2,900,308...2,914,960
JBrowse link
G Mdh1 malate dehydrogenase 1 decreases expression ISO Clozapine results in decreased expression of MDH1 protein CTD PMID:34122009 NCBI chr14:99,831,934...99,847,227
Ensembl chr14:99,831,615...99,847,232
JBrowse link
G Mfn2 mitofusin 2 decreases expression
multiple interactions
EXP Clozapine results in decreased expression of MFN2 protein
PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of MFN2 protein]
CTD PMID:37087062 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase increases expression ISO Clozapine results in increased expression of MLKL protein CTD PMID:31220554 NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Clozapine results in decreased expression of MMP10 mRNA CTD PMID:17346280 NCBI chr 8:12,974,707...12,982,613
Ensembl chr 8:12,974,707...12,982,613
JBrowse link
G Mmp14 matrix metallopeptidase 14 increases expression ISO Clozapine results in increased expression of MMP14 protein CTD PMID:36482696 NCBI chr15:31,857,824...31,867,049
Ensembl chr15:31,857,546...31,869,893
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO Clozapine results in decreased expression of MMP7 mRNA CTD PMID:17346280 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755
JBrowse link
G Mobp myelin-associated oligodendrocyte basic protein increases expression ISO Clozapine results in increased expression of MOBP mRNA CTD PMID:15542763 PMID:17266109 NCBI chr 8:128,747,117...128,777,238
Ensembl chr 8:128,747,232...128,777,936
JBrowse link
G Mpo myeloperoxidase affects response to substance
increases activity
multiple interactions
increases oxidation
ISO MPO protein affects the susceptibility to Clozapine
Clozapine results in increased activity of MPO protein
Clozapine promotes the reaction [[MPO protein results in increased metabolism of chlorodimedone] which results in increased abundance of Hypochlorous Acid]; Clozapine promotes the reaction [MPO protein results in increased abundance of Hypochlorous Acid]
MPO protein results in increased oxidation of Clozapine
CTD PMID:24588327 PMID:35575633 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Mpp3 MAGUK p55 scaffold protein 3 decreases expression ISO Clozapine results in decreased expression of MPP3 mRNA CTD PMID:17266109 NCBI chr10:87,445,905...87,475,461
Ensembl chr10:87,445,905...87,474,811
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Clozapine affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:69,850,420...69,868,302
Ensembl chr13:69,850,420...69,868,502
JBrowse link
G Mta2 metastasis associated 1 family, member 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MTA2 protein CTD PMID:34122009 NCBI chr 1:215,267,286...215,276,008
Ensembl chr 1:215,267,046...215,276,062
JBrowse link
G Mtdh metadherin multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MTDH protein CTD PMID:34122009 NCBI chr 7:67,192,592...67,250,819
Ensembl chr 7:67,192,393...67,249,584
JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR gene polymorphism affects the susceptibility to Clozapine; MTHFR protein affects the susceptibility to Clozapine CTD PMID:20547447 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105
JBrowse link
G Myadm myeloid-associated differentiation marker multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MYADM protein CTD PMID:34122009 NCBI chr 1:74,779,616...74,796,752
Ensembl chr 1:74,775,698...74,789,710
JBrowse link
G Mybbp1a MYB binding protein 1a increases expression ISO Clozapine results in increased expression of MYBBP1A protein CTD PMID:34122009 NCBI chr10:57,555,458...57,565,819
Ensembl chr10:57,555,452...57,566,041
JBrowse link
G Myh10 myosin heavy chain 10 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of MYH10 protein CTD PMID:34122009 NCBI chr10:53,891,955...54,024,032
Ensembl chr10:53,893,166...54,024,036
JBrowse link
G Myh3 myosin heavy chain 3 increases expression ISO Clozapine results in increased expression of MYH3 protein CTD PMID:34122009 NCBI chr10:52,269,185...52,293,000
Ensembl chr10:52,269,185...52,293,000
JBrowse link
G Myl1 myosin, light chain 1 increases expression ISO Clozapine results in increased expression of MYL1 protein CTD PMID:34122009 Ensembl chr 9:75,887,227...75,907,971 JBrowse link
G Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit decreases expression ISO Clozapine results in decreased expression of NAA10 protein CTD PMID:34122009 NCBI chr  X:156,807,378...156,812,632
Ensembl chr  X:156,807,378...156,812,574
JBrowse link
G Nap1l4 nucleosome assembly protein 1-like 4 increases expression ISO Clozapine results in increased expression of NAP1L4 protein CTD PMID:34122009 NCBI chr 1:208,139,105...208,175,597
Ensembl chr 1:208,139,113...208,174,569
JBrowse link
G Nat10 N-acetyltransferase 10 decreases expression ISO Clozapine results in decreased expression of NAT10 protein CTD PMID:34122009 NCBI chr 3:110,566,582...110,604,829
Ensembl chr 3:110,566,582...110,604,836
JBrowse link
G Ncan neurocan decreases expression ISO Clozapine results in decreased expression of NCAN mRNA CTD PMID:18797397 NCBI chr16:19,335,907...19,362,371
Ensembl chr16:19,335,907...19,362,371
JBrowse link
G Ncapg non-SMC condensin I complex, subunit G increases expression ISO Clozapine results in increased expression of NCAPG protein CTD PMID:34122009 NCBI chr14:69,616,473...69,645,445
Ensembl chr14:69,616,473...69,645,445
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H decreases expression ISO Clozapine results in decreased expression of NCAPH protein CTD PMID:34122009 PMID:36482696 NCBI chr 3:134,825,271...134,852,502
Ensembl chr 3:134,825,271...134,852,502
JBrowse link
G Ncbp1 nuclear cap binding protein subunit 1 decreases expression ISO Clozapine results in decreased expression of NCBP1 protein CTD PMID:34122009 NCBI chr 5:65,211,632...65,244,532
Ensembl chr 5:65,211,358...65,244,665
JBrowse link
G Ncl nucleolin increases expression ISO Clozapine results in increased expression of NCL mRNA CTD PMID:14647396 NCBI chr 9:94,447,559...94,456,083
Ensembl chr 9:94,446,682...94,456,083
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 increases expression ISO Clozapine results in increased expression of NCOA4 protein CTD PMID:36482696 NCBI chr16:7,395,502...7,415,846
Ensembl chr16:7,401,802...7,415,840
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression EXP Clozapine results in increased expression of NDUFV2 mRNA CTD PMID:19441803 NCBI chr 9:113,137,305...113,157,571
Ensembl chr 9:113,137,306...113,157,520
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 decreases expression ISO Clozapine results in decreased expression of NECTIN2 protein CTD PMID:34122009 NCBI chr 1:88,500,086...88,535,474
Ensembl chr 1:88,500,087...88,535,305
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase decreases expression ISO Clozapine results in decreased expression of NEDD4 mRNA CTD PMID:18797397 NCBI chr 8:82,264,751...82,349,642
Ensembl chr 8:82,264,649...82,349,633
JBrowse link
G Nes nestin decreases expression ISO Clozapine results in decreased expression of NES protein CTD PMID:34122009 NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to Clozapine CTD PMID:21540358 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression EXP Clozapine results in decreased expression of NFKB1 protein CTD PMID:16500086 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
JBrowse link
G Ngfr nerve growth factor receptor decreases expression ISO
EXP
Clozapine results in decreased expression of NGFR protein; Clozapine results in decreased expression of NGFR protein alternative form
Clozapine results in decreased expression of NGFR mRNA
CTD PMID:12111809 PMID:14598305 PMID:16513140 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305
JBrowse link
G Nifk nucleolar protein interacting with the FHA domain of MKI67 decreases expression ISO Clozapine results in decreased expression of NIFK protein CTD PMID:34122009 NCBI chr13:31,946,119...31,955,950
Ensembl chr13:31,946,108...31,959,561
JBrowse link
G Nnmt nicotinamide N-methyltransferase increases expression ISO Clozapine results in increased expression of NNMT protein CTD PMID:34122009 NCBI chr 8:57,820,156...57,851,301
Ensembl chr 8:57,825,464...57,843,174
JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase decreases expression ISO Clozapine results in decreased expression of NNT protein CTD PMID:34122009 NCBI chr 2:53,144,157...53,237,857
Ensembl chr 2:53,144,160...53,237,310
JBrowse link
G Noc2l NOC2-like nucleolar associated transcriptional repressor increases expression ISO Clozapine results in increased expression of NOC2L protein CTD PMID:34122009 NCBI chr 5:172,102,369...172,114,168
Ensembl chr 5:172,101,223...172,114,162
JBrowse link
G Nomo1 Nodal modulator 1 increases expression ISO Clozapine results in increased expression of NOMO3 protein CTD PMID:34122009 NCBI chr 1:105,641,867...105,692,708
Ensembl chr 1:105,641,879...105,692,707
JBrowse link
G Nop53 NOP53 ribosome biogenesis factor affects expression ISO Clozapine affects the expression of NOP53 mRNA CTD PMID:14647396 NCBI chr 1:85,757,271...85,765,089
Ensembl chr 1:85,756,586...85,765,089
JBrowse link
G Notch2 notch receptor 2 increases expression ISO Clozapine results in increased expression of NOTCH2 protein CTD PMID:36482696 NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:188,299,336...188,432,823
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor decreases expression ISO Clozapine results in decreased expression of NPLOC4 protein CTD PMID:34122009 NCBI chr10:106,152,756...106,208,306
Ensembl chr10:106,153,173...106,208,264
JBrowse link
G Nptn neuroplastin increases expression ISO Clozapine results in increased expression of NPTN mRNA CTD PMID:18797397 NCBI chr 8:67,892,678...67,959,231
Ensembl chr 8:67,892,702...67,959,236
JBrowse link
G Nptx2 neuronal pentraxin 2 decreases expression EXP Clozapine results in decreased expression of NPTX2 mRNA CTD PMID:18208916 NCBI chr12:15,151,136...15,162,045
Ensembl chr12:15,151,136...15,162,045
JBrowse link
G Npy neuropeptide Y decreases expression EXP Clozapine results in decreased expression of NPY mRNA CTD PMID:16516965 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 affects response to substance
multiple interactions
increases reduction
ISO NQO2 gene SNP affects the susceptibility to Clozapine
Clozapine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3]
NQO2 protein results in increased reduction of Clozapine metabolite
CTD PMID:14617031 PMID:29281794 NCBI chr17:31,114,825...31,144,062
Ensembl chr17:31,114,529...31,143,662
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Clozapine results in increased expression of NR0B2 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] CTD PMID:21402137 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Clozapine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein] CTD PMID:16581232 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression
decreases expression
EXP Clozapine results in increased expression of NR4A1 mRNA
Clozapine results in decreased expression of NR4A1 mRNA
CTD PMID:10987852 PMID:11564422 PMID:19695244 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO Clozapine results in increased expression of NR4A2 mRNA CTD PMID:17266109 NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769
JBrowse link
G Nrg1 neuregulin 1 increases expression
affects expression
affects response to substance
ISO
EXP
Clozapine results in increased expression of NRG1 mRNA
Clozapine affects the expression of NRG1 protein
NRG1 protein affects the susceptibility to Clozapine
CTD PMID:15706234 PMID:18184445 PMID:19502011 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase decreases expression ISO Clozapine results in decreased expression of NSF protein CTD PMID:34122009 NCBI chr10:89,227,937...89,357,383
Ensembl chr10:89,227,937...89,367,621
JBrowse link
G Ntng2 netrin G2 increases expression EXP Clozapine results in increased expression of NTNG2 mRNA CTD PMID:17507910 NCBI chr 3:32,889,856...32,949,032
Ensembl chr 3:32,890,575...32,943,821
JBrowse link
G Nts neurotensin increases expression EXP Clozapine results in increased expression of NTS mRNA CTD PMID:12887421 NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:39,451,073...39,460,961
JBrowse link
G Numa1 nuclear mitotic apparatus protein 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of NUMA1 protein CTD PMID:34122009 NCBI chr 1:165,709,893...165,784,848
Ensembl chr 1:165,709,905...165,784,848
JBrowse link
G Numbl NUMB-like, endocytic adaptor protein decreases expression ISO Clozapine results in decreased expression of NUMBL mRNA CTD PMID:18797397 NCBI chr 1:91,677,437...91,701,415
Ensembl chr 1:91,677,242...91,701,424
JBrowse link
G Nup160 nucleoporin 160 increases expression ISO Clozapine results in increased expression of NUP160 protein CTD PMID:34122009 NCBI chr 3:97,120,723...97,183,227
Ensembl chr 3:97,121,628...97,180,720
JBrowse link
G Nup50 nucleoporin 50 increases expression ISO Clozapine results in increased expression of NUP50 protein CTD PMID:34122009 NCBI chr 7:117,927,882...117,945,155
Ensembl chr 7:117,925,716...117,946,959
JBrowse link
G Nup54 nucleoporin 54 decreases expression ISO Clozapine results in decreased expression of NUP54 protein CTD PMID:34122009 NCBI chr14:15,901,936...15,920,335
Ensembl chr14:15,901,991...15,920,334
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Clozapine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901
JBrowse link
G Osbpl8 oxysterol binding protein-like 8 increases expression ISO Clozapine results in increased expression of OSBPL8 mRNA CTD PMID:14647396 NCBI chr 7:48,483,259...48,636,151
Ensembl chr 7:48,483,022...48,636,151
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide affects response to substance ISO OXT protein affects the susceptibility to Clozapine CTD PMID:20196918 NCBI chr 3:138,235,754...138,236,594
Ensembl chr 3:138,235,754...138,236,594
JBrowse link
G Pakap paralemmin A kinase anchor protein multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of PALM2AKAP2 protein CTD PMID:34122009 NCBI chr 5:76,976,906...77,443,656
Ensembl chr 5:76,977,112...77,443,656
JBrowse link
G Pank3 pantothenate kinase 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of PANK3 protein CTD PMID:34122009 NCBI chr10:20,733,191...20,757,017
Ensembl chr10:20,733,127...20,757,015
JBrowse link
G Park7 Parkinsonism associated deglycase increases expression ISO Clozapine results in increased expression of PARK7 mRNA CTD PMID:14647396 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825
JBrowse link
G Pcbp1 poly(rC) binding protein 1 increases expression ISO Clozapine results in increased expression of PCBP1 protein CTD PMID:34122009 NCBI chr 4:120,530,100...120,532,107
Ensembl chr 4:120,529,172...120,539,111
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) decreases expression ISO Clozapine results in decreased expression of PCK2 protein CTD PMID:34122009 NCBI chr15:32,997,853...33,006,691
Ensembl chr15:32,997,834...33,016,864
JBrowse link
G Pclo piccolo (presynaptic cytomatrix protein) multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of PCLO protein CTD PMID:34122009 NCBI chr 4:20,646,604...21,005,171
Ensembl chr 4:20,646,604...21,005,111
JBrowse link
G Pcm1 pericentriolar material 1 decreases expression ISO Clozapine results in decreased expression of PCM1 mRNA CTD PMID:19048012 NCBI chr16:57,711,833...57,808,842
Ensembl chr16:57,711,833...57,808,599
JBrowse link
G Pcnp PEST proteolytic signal containing nuclear protein increases expression ISO Clozapine results in increased expression of PCNP protein CTD PMID:34122009 NCBI chr11:58,061,885...58,076,436
Ensembl chr11:58,061,570...58,076,436
JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor affects expression ISO Clozapine affects the expression of PCSK1N mRNA CTD PMID:14647396 NCBI chr  X:17,251,963...17,255,405
Ensembl chr  X:17,251,965...17,257,360
JBrowse link
G Pdcd11 programmed cell death 11 increases expression ISO Clozapine results in increased expression of PDCD11 protein CTD PMID:34122009 NCBI chr 1:255,922,198...255,963,336
Ensembl chr 1:255,922,225...255,963,336
JBrowse link
G Pde10a phosphodiesterase 10A increases expression ISO
EXP
Clozapine results in increased expression of PDE10A mRNA
Clozapine results in increased expression of PDE10A mRNA; Clozapine results in increased expression of PDE10A protein
CTD PMID:17266109 PMID:18222493 NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:54,317,732...54,764,051
JBrowse link
G Pde1b phosphodiesterase 1B increases expression ISO Clozapine results in increased expression of PDE1B mRNA CTD PMID:14647396 NCBI chr 7:136,505,834...136,533,034
Ensembl chr 7:136,505,689...136,533,033
JBrowse link
G Pde4a phosphodiesterase 4A decreases expression EXP Clozapine results in decreased expression of PDE4A protein CTD PMID:20222156 NCBI chr 8:27,966,978...28,029,721
Ensembl chr 8:27,966,996...28,046,924
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression
increases expression
EXP Clozapine results in decreased expression of PDE4B protein
Clozapine results in increased expression of PDE4B mRNA; Clozapine results in increased expression of PDE4B protein
CTD PMID:18222493 PMID:20222156 NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression ISO Clozapine results in decreased expression of PDIA3 protein CTD PMID:34122009 NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of PDIA4 protein CTD PMID:34122009 NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:78,134,144...78,153,191
JBrowse link
G Pdlim5 PDZ and LIM domain 5 decreases expression ISO Clozapine results in decreased expression of PDLIM5 protein CTD PMID:34122009 NCBI chr 2:233,625,478...233,793,582
Ensembl chr 2:233,628,503...233,793,528
JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 decreases expression ISO Clozapine results in decreased expression of PEBP1 protein CTD PMID:34122009 NCBI chr12:44,946,307...44,967,890
Ensembl chr12:44,963,675...44,971,780
JBrowse link
G Penk proenkephalin decreases expression
increases expression
EXP Clozapine results in decreased expression of PENK mRNA
Clozapine results in increased expression of PENK mRNA
CTD PMID:1635659 PMID:12887421 NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:21,981,382...21,986,705
JBrowse link
G Pfdn5 prefoldin subunit 5 increases expression ISO Clozapine results in increased expression of PFDN5 mRNA CTD PMID:14647396 NCBI chr 7:135,330,364...135,335,102
Ensembl chr 7:135,330,172...135,335,099
JBrowse link
G Pfkp phosphofructokinase, platelet increases expression EXP Clozapine results in increased expression of PFKP mRNA CTD PMID:15860345 NCBI chr17:68,639,749...68,704,055
Ensembl chr17:68,639,481...68,705,752
JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase decreases expression ISO Clozapine results in decreased expression of PGAM5 protein CTD PMID:34122009 NCBI chr12:52,069,023...52,076,131
Ensembl chr12:52,069,103...52,076,131
JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression EXP Clozapine results in increased expression of PGK1 mRNA CTD PMID:15860345 NCBI chr  X:75,336,988...75,352,962
Ensembl chr  X:75,336,687...75,352,959
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 multiple interactions EXP PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein]; PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of MFN2 protein] CTD PMID:37087062 NCBI chr  X:120,698,610...120,706,805
Ensembl chr  X:120,698,610...120,706,805
JBrowse link
G Phactr1 phosphatase and actin regulator 1 increases expression ISO Clozapine results in increased expression of PHACTR1 mRNA CTD PMID:14647396 NCBI chr17:21,769,006...22,246,227
Ensembl chr17:21,768,662...22,244,586
JBrowse link
G Phf14 PHD finger protein 14 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of PHF14 protein CTD PMID:34122009 NCBI chr 4:40,975,897...41,162,043
Ensembl chr 4:40,975,439...41,162,043
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 decreases expression EXP Clozapine results in decreased expression of PIK3R3 mRNA CTD PMID:16715494 NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762
JBrowse link
G Pitpnb phosphatidylinositol transfer protein, beta increases expression ISO Clozapine results in increased expression of PITPNB protein CTD PMID:34122009 NCBI chr12:50,909,140...50,958,193
Ensembl chr12:50,909,143...50,958,140
JBrowse link
G Pkib cAMP-dependent protein kinase inhibitor beta decreases expression EXP Clozapine results in decreased expression of PKIB mRNA CTD PMID:15860345 NCBI chr20:37,511,564...37,608,607
Ensembl chr20:37,512,822...37,608,401
JBrowse link
G Pkm pyruvate kinase M1/2 increases expression EXP Clozapine results in increased expression of PKM mRNA CTD PMID:15860345 NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396
JBrowse link
G Plcb1 phospholipase C beta 1 increases expression ISO Clozapine results in increased expression of PLCB1 mRNA CTD PMID:16465460 NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646
JBrowse link
G Plp1 proteolipid protein 1 decreases expression
increases expression
ISO Clozapine results in decreased expression of PLP1 mRNA
Clozapine results in increased expression of PLP1 mRNA
CTD PMID:17266109 PMID:18797397 NCBI chr  X:104,933,921...104,993,317
Ensembl chr  X:104,975,780...104,993,314
JBrowse link
G Pls3 plastin 3 decreases expression ISO Clozapine results in decreased expression of PLS3 protein CTD PMID:34122009 NCBI chr  X:116,401,247...116,495,898
Ensembl chr  X:116,401,293...116,495,893
JBrowse link
G Pnma1 PNMA family member 1 increases expression ISO Clozapine results in increased expression of PNMA1 protein CTD PMID:34122009 NCBI chr 6:109,513,382...109,515,167
Ensembl chr 6:109,507,773...109,515,451
JBrowse link
G Pon3 paraoxonase 3 increases expression ISO Clozapine results in increased expression of PON3 protein CTD PMID:34122009 NCBI chr 4:34,323,546...34,350,244
Ensembl chr 4:34,315,889...34,350,244
JBrowse link
G Ppa1 inorganic pyrophosphatase 1 increases expression ISO Clozapine results in increased expression of PPA1 protein CTD PMID:34122009 NCBI chr20:30,132,088...30,160,492
Ensembl chr20:30,133,504...30,160,489
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]
Clozapine results in increased expression of PPARG mRNA; Clozapine results in increased expression of PPARG protein
CTD PMID:20564506 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
JBrowse link
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A decreases expression EXP Clozapine results in decreased expression of PPM1A mRNA CTD PMID:15860345 NCBI chr 6:97,174,955...97,216,585
Ensembl chr 6:97,174,916...97,216,574
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B decreases expression EXP Clozapine results in decreased expression of PPM1B mRNA CTD PMID:15860345 NCBI chr 6:15,399,559...15,460,301
Ensembl chr 6:15,399,562...15,460,756
JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta decreases expression EXP Clozapine results in decreased expression of PPP1CB mRNA CTD PMID:15860345 NCBI chr 6:29,681,099...29,712,835
Ensembl chr 6:29,681,100...29,712,924
JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma decreases expression EXP Clozapine results in decreased expression of PPP1CC mRNA CTD PMID:15860345 NCBI chr12:40,043,822...40,061,301
Ensembl chr12:40,043,822...40,061,341
JBrowse link
G Ppp1r14b protein phosphatase 1, regulatory (inhibitor) subunit 14B decreases expression ISO Clozapine results in decreased expression of PPP1R14B protein CTD PMID:34122009 NCBI chr 1:213,594,416...213,596,527
Ensembl chr12:21,088,517...21,101,431
Ensembl chr 1:21,088,517...21,101,431
JBrowse link
G Ppp1r1a protein phosphatase 1, regulatory (inhibitor) subunit 1A decreases expression EXP Clozapine results in decreased expression of PPP1R1A mRNA CTD PMID:15860345 NCBI chr 7:136,533,031...136,540,687
Ensembl chr 7:136,523,604...136,540,683
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions
increases phosphorylation
ISO Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]
Clozapine results in increased phosphorylation of PPP1R1B protein
CTD PMID:11880652 PMID:12871586 NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,844,036...83,853,063
JBrowse link
G Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 decreases expression EXP Clozapine results in decreased expression of PPP1R2 mRNA CTD PMID:15860345 NCBI chr11:82,977,634...82,999,426
Ensembl chr11:82,977,515...83,001,083
JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B increases expression EXP Clozapine results in increased expression of PPP1R9B protein CTD PMID:16844384 NCBI chr10:80,434,888...80,450,919
Ensembl chr10:80,434,900...80,450,919
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha decreases expression EXP Clozapine results in decreased expression of PPP2CA mRNA CTD PMID:15860345 NCBI chr10:36,856,534...36,878,789 JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression EXP Clozapine results in decreased expression of PPP2CB mRNA CTD PMID:15860345 NCBI chr16:65,261,178...65,282,658
Ensembl chr16:65,261,181...65,282,634
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression EXP Clozapine results in increased expression of PPP2R1A mRNA CTD PMID:15860345 NCBI chr 1:69,213,198...69,232,441
Ensembl chr 1:69,213,038...69,238,242
JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha decreases expression EXP Clozapine results in decreased expression of PPP2R2A mRNA CTD PMID:15860345 NCBI chr15:45,380,142...45,439,428
Ensembl chr15:45,379,683...45,439,405
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions
increases expression
decreases expression
EXP [Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein
Clozapine results in increased expression of PPP3CA mRNA
Clozapine results in decreased expression of PPP3CA mRNA; Clozapine results in decreased expression of PPP3CA protein
CTD PMID:12437575 PMID:16033416 NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:227,839,062...228,113,554
JBrowse link
G Ppp4r2 protein phosphatase 4, regulatory subunit 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of PPP4R2 protein CTD PMID:34122009 NCBI chr 4:135,010,919...135,051,844
Ensembl chr 4:135,010,919...135,051,844
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit affects expression ISO Clozapine affects the expression of PPP5C mRNA CTD PMID:14647396 NCBI chr 1:86,818,297...86,842,505
Ensembl chr 1:86,818,297...86,842,950
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of PRDX1 protein CTD PMID:34122009 NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases expression EXP Clozapine results in increased expression of PRKACA mRNA CTD PMID:15860345 NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta decreases expression
increases expression
EXP Clozapine results in decreased expression of PRKACB mRNA; Clozapine results in decreased expression of PRKACB protein
Clozapine results in increased expression of PRKACB mRNA
CTD PMID:11907174 PMID:15860345 NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:238,300,127...238,386,315
JBrowse link
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha multiple interactions
decreases expression
EXP
ISO
Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2A protein]
[Cuprizone co-treated with Clozapine] results in decreased expression of PRKAR2A protein
Clozapine results in decreased expression of PRKAR2A mRNA; Clozapine results in decreased expression of PRKAR2A protein
CTD PMID:11907174 PMID:34122009 NCBI chr 8:118,271,608...118,337,332
Ensembl chr 8:118,274,167...118,337,330
JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta decreases expression
multiple interactions
EXP Clozapine results in decreased expression of PRKAR2B mRNA; Clozapine results in decreased expression of PRKAR2B protein
Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2B protein]
CTD PMID:11907174 PMID:15860345 NCBI chr 6:54,291,143...54,381,639
Ensembl chr 6:54,291,151...54,381,411
JBrowse link
G Prkcb protein kinase C, beta affects expression
increases expression
EXP Clozapine affects the expression of PRKCB protein
Clozapine results in increased expression of PRKCB mRNA
CTD PMID:15860345 PMID:15967061 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740
JBrowse link
G Prkce protein kinase C, epsilon increases expression EXP Clozapine results in increased expression of PRKCE mRNA CTD PMID:15860345 NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288
JBrowse link
G Prkcz protein kinase C, zeta increases expression EXP Clozapine results in increased expression of PRKCZ mRNA CTD PMID:15860345 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674
JBrowse link
G Prl prolactin increases secretion
increases expression
multiple interactions
ISO
EXP
Clozapine results in increased secretion of PRL protein
Clozapine analog results in increased expression of PRL protein
[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein; [Risperidone co-treated with Clozapine] results in increased expression of PRL protein
CTD PMID:11155212 PMID:11997696 PMID:15286066 PMID:18562423 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217
JBrowse link
G Prmt1 protein arginine methyltransferase 1 decreases expression ISO Clozapine results in decreased expression of PRMT1 protein CTD PMID:34122009 NCBI chr 1:104,595,339...104,605,552
Ensembl chr 1:104,595,335...104,604,827
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa increases expression ISO Clozapine results in increased expression of PROC protein CTD PMID:20126316 NCBI chr18:24,038,596...24,049,061
Ensembl chr18:24,038,597...24,048,964
JBrowse link
G Prpf38b pre-mRNA processing factor 38B decreases expression ISO Clozapine results in decreased expression of PRPF38B mRNA CTD PMID:14647396 NCBI chr 2:199,241,312...199,250,342
Ensembl chr 2:199,241,313...199,250,338
JBrowse link
G Prpf6 pre-mRNA processing factor 6 decreases expression
multiple interactions
ISO Clozapine results in decreased expression of PRPF6 protein
[Cuprizone co-treated with Clozapine] results in decreased expression of PRPF6 protein
CTD PMID:34122009 NCBI chr 3:189,084,465...189,148,705
Ensembl chr 3:189,081,794...189,152,786
JBrowse link
G Prrc2a proline-rich coiled-coil 2A decreases expression ISO Clozapine results in decreased expression of PRRC2A mRNA CTD PMID:18797397 NCBI chr20:3,660,981...3,686,715
Ensembl chr20:3,663,400...3,678,778
JBrowse link
G Psmb5 proteasome 20S subunit beta 5 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of PSMB5 protein CTD PMID:34122009 NCBI chr15:32,042,784...32,047,379
Ensembl chr15:32,042,787...32,047,379
JBrowse link
G Psmb7 proteasome 20S subunit beta 7 decreases expression ISO Clozapine results in decreased expression of PSMB7 protein CTD PMID:34122009 NCBI chr 3:42,767,500...42,827,470
Ensembl chr 3:42,767,501...42,827,601
JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 increases expression ISO Clozapine results in increased expression of PSMC3 protein CTD PMID:34122009 NCBI chr 3:97,487,643...97,493,025
Ensembl chr 3:97,487,632...97,499,176
JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 increases expression ISO Clozapine results in increased expression of PSMC5 protein CTD PMID:34122009 NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,686,295...91,695,921
JBrowse link
G Psmd14 proteasome 26S subunit, non-ATPase 14 increases expression ISO Clozapine results in increased expression of PSMD14 protein CTD PMID:34122009 NCBI chr 3:66,662,933...66,755,666
Ensembl chr 3:66,662,900...66,755,665
JBrowse link
G Psmd7 proteasome 26S subunit, non-ATPase 7 increases expression ISO Clozapine results in increased expression of PSMD7 protein CTD PMID:34122009 NCBI chr19:52,404,032...52,411,316
Ensembl chr19:52,404,032...52,417,871
JBrowse link
G Ptcd3 Pentatricopeptide repeat domain 3 increases expression ISO Clozapine results in increased expression of PTCD3 protein CTD PMID:34122009 NCBI chr 4:105,480,699...105,508,007
Ensembl chr 4:105,480,709...105,513,276
JBrowse link
G Ptgds prostaglandin D2 synthase decreases expression
increases expression
ISO Clozapine results in decreased expression of PTGDS mRNA
Clozapine results in increased expression of PTGDS mRNA
CTD PMID:15542763 PMID:17266109 NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:28,680,044...28,682,978
JBrowse link
G Ptk2 protein tyrosine kinase 2 increases expression ISO Clozapine results in increased expression of PTK2 protein CTD PMID:34122009 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091
JBrowse link
G Ptma prothymosin alpha increases expression ISO Clozapine results in increased expression of PTMA protein CTD PMID:34122009 NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:94,624,196...94,628,276
JBrowse link
G Ptms parathymosin increases expression ISO Clozapine results in increased expression of PTMS mRNA CTD PMID:14647396 NCBI chr 4:159,408,647...159,412,837
Ensembl chr 4:159,408,649...159,415,212
JBrowse link
G Pvalb parvalbumin multiple interactions EXP Clozapine inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA] CTD PMID:12589379 NCBI chr 7:111,653,820...111,668,469
Ensembl chr 7:111,653,111...111,668,446
JBrowse link
G Pwp2 PWP2, small subunit processome component increases expression ISO Clozapine results in increased expression of PWP2 protein CTD PMID:34122009 NCBI chr20:10,498,998...10,512,631
Ensembl chr20:10,499,013...10,513,309
JBrowse link
G Pycr1 pyrroline-5-carboxylate reductase 1 increases expression ISO Clozapine results in increased expression of PYCR1 protein CTD PMID:34122009 NCBI chr10:106,416,056...106,420,982
Ensembl chr10:106,412,576...106,423,393
JBrowse link
G Qdpr quinoid dihydropteridine reductase decreases expression ISO Clozapine results in decreased expression of QDPR protein CTD PMID:34122009 NCBI chr14:69,882,776...69,896,378
Ensembl chr14:69,882,612...69,896,379
JBrowse link
G Rab12 RAB12, member RAS oncogene family decreases expression EXP Clozapine results in decreased expression of RAB12 mRNA CTD PMID:12437575 NCBI chr 9:113,927,119...113,953,722
Ensembl chr 9:113,927,119...113,953,695
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of RAC1 protein CTD PMID:34122009 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109
JBrowse link
G Rack1 receptor for activated C kinase 1 decreases expression ISO Clozapine results in decreased expression of RACK1 protein CTD PMID:34122009 NCBI chr10:33,668,560...33,676,031
Ensembl chr10:33,670,270...33,675,948
JBrowse link
G Ralyl RALY RNA binding protein-like increases expression ISO Clozapine results in increased expression of RALYL protein CTD PMID:34122009 NCBI chr 2:89,390,212...90,181,681
Ensembl chr 2:89,390,129...90,181,624
JBrowse link
G Ran RAN, member RAS oncogene family decreases expression ISO Clozapine results in decreased expression of RAN protein CTD PMID:34122009 NCBI chr12:33,311,155...33,314,339
Ensembl chr12:33,311,158...33,314,317
JBrowse link
G Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 increases expression ISO Clozapine results in increased expression of RAP1GDS1 protein CTD PMID:34122009 NCBI chr 2:230,173,713...230,318,555
Ensembl chr 2:230,173,713...230,318,538
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO Clozapine results in decreased expression of RAPGEF4 mRNA CTD PMID:18797397 NCBI chr 3:77,217,024...77,509,933
Ensembl chr 3:77,217,039...77,509,978
JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 affects expression EXP Clozapine affects the expression of RASGRF1 mRNA CTD PMID:12437575 NCBI chr 8:99,324,986...99,454,099
Ensembl chr 8:99,324,749...99,454,089
JBrowse link
G Rbbp4 RB binding protein 4, chromatin remodeling factor decreases expression ISO Clozapine results in decreased expression of RBBP4 protein CTD PMID:34122009 NCBI chr 5:146,940,207...146,959,501
Ensembl chr 5:146,922,611...146,959,501
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression EXP Clozapine results in decreased expression of RELA protein CTD PMID:16500086 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Reln reelin decreases expression
multiple interactions
decreases methylation
ISO
EXP
Clozapine results in decreased expression of RELN mRNA
Clozapine results in decreased expression of RELN protein
Valproic Acid promotes the reaction [Clozapine results in decreased methylation of RELN promoter]
CTD PMID:17266109 PMID:18757738 PMID:19359144 NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162
JBrowse link
G Rfc5 replication factor C subunit 5 increases expression ISO Clozapine results in increased expression of RFC5 protein CTD PMID:34122009 NCBI chr12:44,868,322...44,877,879
Ensembl chr12:44,862,329...44,878,151
JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression EXP
ISO
Clozapine results in increased expression of RGS4 mRNA CTD PMID:15860345 PMID:17266109 NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884
JBrowse link
G Rgs7 regulator of G-protein signaling 7 multiple interactions
increases expression
EXP [[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]
Clozapine results in increased expression of RGS7 mRNA
CTD PMID:18976543 NCBI chr13:89,511,492...89,941,082
Ensembl chr13:89,511,150...89,940,987
JBrowse link
G Rgs8 regulator of G-protein signaling 8 increases expression EXP Clozapine results in increased expression of RGS8 mRNA CTD PMID:15860345 NCBI chr13:68,355,078...68,399,412
Ensembl chr13:68,355,157...68,399,412
JBrowse link
G Rhob ras homolog family member B increases expression ISO Clozapine results in increased expression of RHOB protein CTD PMID:36482696 NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772
JBrowse link
G Ric8a RIC8 guanine nucleotide exchange factor A decreases expression ISO Clozapine results in decreased expression of RIC8A protein CTD PMID:34122009 NCBI chr 1:205,364,796...205,371,102
Ensembl chr 1:205,363,882...205,371,102
JBrowse link
G Rnf13 ring finger protein 13 increases expression ISO Clozapine results in increased expression of RNF13 protein CTD PMID:36482696 NCBI chr 2:144,076,526...144,211,520
Ensembl chr 2:144,077,916...144,211,798
JBrowse link
G Rnf20 ring finger protein 20 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of RNF20 protein CTD PMID:34122009 NCBI chr 5:68,771,507...68,797,240
Ensembl chr 5:68,771,535...68,797,240
JBrowse link
G Rorb RAR-related orphan receptor B decreases expression EXP Clozapine results in decreased expression of RORB mRNA CTD PMID:11564422 NCBI chr 1:225,790,216...225,970,973
Ensembl chr 1:225,790,216...225,970,973
JBrowse link
G Rpa1 replication protein A1 decreases expression ISO Clozapine results in decreased expression of RPA1 protein CTD PMID:34122009 NCBI chr10:60,647,185...60,698,279
Ensembl chr10:60,647,185...60,698,279
JBrowse link
G Rpl11 ribosomal protein L11 increases expression ISO Clozapine results in increased expression of RPL11 protein CTD PMID:34122009 NCBI chr 5:153,557,592...153,561,230
Ensembl chr 5:153,557,597...153,561,127
JBrowse link
G Rpl19 ribosomal protein L19 increases expression ISO Clozapine results in increased expression of RPL19 protein CTD PMID:34122009 NCBI chr10:83,514,509...83,522,352
Ensembl chr10:83,515,464...83,522,352
JBrowse link
G Rpl30 ribosomal protein L30 increases expression ISO Clozapine results in increased expression of RPL30 protein CTD PMID:34122009 NCBI chr 7:67,533,420...67,536,555
Ensembl chr 7:67,465,332...67,536,555
JBrowse link
G Rpl5 ribosomal protein L5 increases expression ISO Clozapine results in increased expression of RPL5 protein CTD PMID:34122009 NCBI chr14:1,988,792...1,995,236
Ensembl chr14:1,988,793...1,995,225
JBrowse link
G Rplp0l1 ribosomal protein lateral stalk subunit P0 like 1 decreases expression ISO Clozapine results in decreased expression of RPLP0P6 protein CTD PMID:34122009 NCBI chr 2:194,609,881...194,611,022
Ensembl chr 2:194,609,950...194,611,022
JBrowse link
G Rplp2 ribosomal protein lateral stalk subunit P2 increases expression ISO Clozapine results in increased expression of RPLP2 mRNA CTD PMID:14647396 NCBI chr 1:205,975,598...205,978,192
Ensembl chr 1:205,975,894...205,978,191
JBrowse link
G Rpn2 ribophorin II decreases expression ISO Clozapine results in decreased expression of RPN2 protein CTD PMID:34122009 NCBI chr 3:166,361,955...166,409,272
Ensembl chr 3:166,362,049...166,409,922
JBrowse link
G Rps10 ribosomal protein S10 increases expression ISO Clozapine results in increased expression of RPS10 mRNA CTD PMID:14647396 NCBI chr20:5,696,135...5,700,863
Ensembl chr20:5,696,135...5,700,150
Ensembl chr 6:5,696,135...5,700,150
JBrowse link
G Rps11 ribosomal protein S11 decreases expression ISO Clozapine results in decreased expression of RPS11 protein CTD PMID:34122009 NCBI chr 1:104,742,153...104,744,261
Ensembl chr 1:104,742,155...104,744,337
JBrowse link
G Rps3 ribosomal protein S3 decreases expression ISO Clozapine results in decreased expression of RPS3 protein CTD PMID:34122009 NCBI chr 1:163,190,476...163,195,885
Ensembl chr 1:163,189,842...163,195,776
JBrowse link
G Rrbp1 ribosome binding protein 1 decreases expression ISO Clozapine results in decreased expression of RRBP1 protein CTD PMID:34122009 NCBI chr 3:151,768,386...151,830,255
Ensembl chr 3:151,768,386...151,830,255
JBrowse link
G Rsf1 remodeling and spacing factor 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of RSF1 protein CTD PMID:34122009 NCBI chr 1:161,303,596...161,426,326
Ensembl chr 1:161,303,660...161,420,290
JBrowse link
G Rspry1 ring finger and SPRY domain containing 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of RSPRY1 protein CTD PMID:34122009 NCBI chr19:10,358,423...10,408,988
Ensembl chr19:10,359,795...10,407,076
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 increases expression ISO Clozapine results in increased expression of HLA-E protein CTD PMID:36482696 NCBI chr20:4,872,720...4,876,425 JBrowse link
G Rtcb RNA 2',3'-cyclic phosphate and 5'-OH ligase increases expression ISO Clozapine results in increased expression of RTCB protein CTD PMID:34122009 NCBI chr 7:19,795,393...19,814,875
Ensembl chr 7:19,795,393...19,814,875
JBrowse link
G Rtn4 reticulon 4 increases expression ISO Clozapine results in increased expression of RTN4 mRNA CTD PMID:17266109 NCBI chr14:107,651,001...107,698,610
Ensembl chr14:107,650,732...107,698,611
JBrowse link
G Rxrg retinoid X receptor gamma decreases expression EXP Clozapine results in decreased expression of RXRG mRNA alternative form CTD PMID:11564422 NCBI chr13:82,276,330...82,318,097
Ensembl chr13:82,276,291...82,318,095
JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression ISO Clozapine results in decreased expression of S100A9 mRNA CTD PMID:18797397 NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870
JBrowse link
G Safb scaffold attachment factor B increases expression ISO Clozapine results in increased expression of SAFB protein CTD PMID:34122009 NCBI chr 9:1,504,657...1,525,545
Ensembl chr 9:1,504,456...1,525,781
JBrowse link
G Sars1 seryl-tRNA synthetase 1 decreases expression ISO Clozapine results in decreased expression of SARS1 protein CTD PMID:34122009 NCBI chr 2:198,753,673...198,769,411
Ensembl chr 2:198,753,675...198,769,365
JBrowse link
G Satb2 SATB homeobox 2 increases expression ISO Clozapine results in increased expression of SATB2 protein CTD PMID:34122009 NCBI chr 9:65,842,351...66,028,569
Ensembl chr 9:65,844,570...66,021,238
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Clozapine results in increased expression of SC5D mRNA CTD PMID:17052361 NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Clozapine results in increased expression of SCD mRNA CTD PMID:16027736 PMID:17052361 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785
JBrowse link
G Sdcbp syndecan binding protein decreases expression
increases expression
ISO Clozapine results in decreased expression of SDCBP protein
Clozapine results in increased expression of SDCBP protein
CTD PMID:34122009 PMID:36482696 NCBI chr 5:24,245,279...24,314,712
Ensembl chr 5:24,245,033...24,326,197
JBrowse link
G Sec1 secretory blood group 1 decreases expression
increases expression
EXP Clozapine results in decreased expression of SEC1 mRNA
Clozapine results in increased expression of SEC1 mRNA
CTD PMID:12437575 NCBI chr 1:105,287,093...105,301,588
Ensembl chr 1:105,287,443...105,301,793
JBrowse link
G Sec31a SEC31 homolog A, COPII coat complex component increases expression ISO Clozapine results in increased expression of SEC31A protein CTD PMID:34122009 NCBI chr14:9,518,655...9,573,579
Ensembl chr14:9,518,648...9,573,585
JBrowse link
G Sec61b SEC61 translocon subunit beta increases expression ISO Clozapine results in increased expression of SEC61B protein CTD PMID:34122009 NCBI chr 5:66,569,184...66,577,394
Ensembl chr 5:66,569,196...66,580,028
JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator increases expression ISO Clozapine results in increased expression of SEC63 protein CTD PMID:34122009 NCBI chr20:47,827,291...47,896,248
Ensembl chr20:47,827,291...47,896,248
JBrowse link
G Septin14 septin 14 decreases expression ISO Clozapine results in decreased expression of SEPTIN14 protein CTD PMID:34122009 NCBI chr12:32,610,600...32,641,391
Ensembl chr12:32,611,434...32,641,391
JBrowse link
G Serinc1 serine incorporator 1 increases expression ISO Clozapine results in increased expression of SERINC1 protein CTD PMID:36482696 NCBI chr20:37,396,497...37,415,433
Ensembl chr20:37,396,497...37,443,124
JBrowse link
G Serpina3n serpin family A member 3N increases expression ISO Clozapine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415
JBrowse link
G Serpine2 serpin family E member 2 increases expression EXP Clozapine results in increased expression of SERPINE2 mRNA; Clozapine results in increased expression of SERPINE2 protein CTD PMID:15354176 NCBI chr 9:88,573,138...88,637,252
Ensembl chr 9:88,573,149...88,637,202
JBrowse link
G Set Set nuclear proto-oncogene multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of SET protein CTD PMID:34122009 NCBI chr 3:33,732,319...33,743,433 JBrowse link
G Setx senataxin increases expression ISO Clozapine results in increased expression of SETX protein CTD PMID:34122009 NCBI chr 3:32,825,771...32,878,740
Ensembl chr 3:32,828,412...32,878,740
JBrowse link
G Sf3b3 splicing factor 3b, subunit 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SF3B3 protein CTD PMID:34122009 NCBI chr19:55,692,124...55,729,640
Ensembl chr19:55,692,126...55,729,621
JBrowse link
G Sfpq splicing factor proline and glutamine rich decreases expression ISO Clozapine results in decreased expression of SFPQ protein CTD PMID:34122009 NCBI chr 5:144,621,678...144,637,930
Ensembl chr 5:144,622,476...144,637,926
JBrowse link
G Sfxn1 sideroflexin 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SFXN1 protein CTD PMID:34122009 NCBI chr17:10,491,315...10,527,793
Ensembl chr17:10,491,344...10,527,456
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO
EXP
Clozapine results in increased expression of SGK1 mRNA CTD PMID:17266109 PMID:18208916 NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231
JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 increases expression ISO Clozapine results in increased expression of SH3GL1 protein CTD PMID:34122009 NCBI chr 9:929,459...956,922
Ensembl chr 9:928,563...956,890
JBrowse link
G Sh3kbp1 SH3 domain-containing kinase-binding protein 1 increases expression ISO Clozapine results in increased expression of SH3KBP1 protein CTD PMID:34122009 NCBI chr  X:38,686,530...39,031,658
Ensembl chr  X:38,686,530...39,031,393
JBrowse link
G Sh3pxd2b SH3 and PX domains 2B multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SH3PXD2B protein CTD PMID:34122009 NCBI chr10:17,422,906...17,538,977
Ensembl chr10:17,422,947...17,512,854
JBrowse link
G Sim2 SIM bHLH transcription factor 2 decreases expression ISO Clozapine results in decreased expression of SIM2 protein CTD PMID:34122009 NCBI chr11:46,883,859...46,923,305
Ensembl chr11:46,883,859...46,923,305
JBrowse link
G Sirt2 sirtuin 2 increases expression ISO Clozapine results in increased expression of SIRT2 protein CTD PMID:36482696 NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:93,181,224...93,204,499
JBrowse link
G Skp1 S-phase kinase-associated protein 1 decreases expression ISO Clozapine results in decreased expression of SKP1 protein CTD PMID:34122009 NCBI chr10:36,898,670...36,917,828
Ensembl chr10:36,903,078...36,918,308
JBrowse link
G Slc17a6 solute carrier family 17 member 6 increases expression ISO Clozapine results in increased expression of SLC17A6 mRNA; Clozapine results in increased expression of SLC17A6 protein CTD PMID:17266109 PMID:18155072 NCBI chr 1:110,348,447...110,388,499
Ensembl chr 1:110,348,447...110,388,498
JBrowse link
G Slc17a7 solute carrier family 17 member 7 increases expression ISO Clozapine results in increased expression of SLC17A7 mRNA; Clozapine results in increased expression of SLC17A7 protein CTD PMID:16111724 NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:104,785,955...104,798,049
JBrowse link
G Slc18a2 solute carrier family 18 member A2 increases expression EXP Clozapine results in increased expression of SLC18A2 mRNA; Clozapine results in increased expression of SLC18A2 protein CTD PMID:12007678 NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:268,400,016...268,435,231
JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases expression EXP Clozapine results in decreased expression of SLC1A1 mRNA CTD PMID:12873733 NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:235,963,437...236,045,469
JBrowse link
G Slc1a2 solute carrier family 1 member 2 decreases activity
decreases expression
EXP Clozapine results in decreased activity of SLC1A2 protein
Clozapine results in decreased expression of SLC1A2 mRNA; Clozapine results in decreased expression of SLC1A2 protein
CTD PMID:11443521 PMID:12873733 NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Clozapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Clozapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:30465787 NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077
JBrowse link
G Slc25a13 solute carrier family 25 member 13 increases expression ISO Clozapine results in increased expression of SLC25A13 protein CTD PMID:34122009 NCBI chr 4:35,145,721...35,328,403
Ensembl chr 4:35,145,721...35,328,360
JBrowse link
G Slc25a24 solute carrier family 25 member 24 increases expression ISO Clozapine results in increased expression of SLC25A24 protein CTD PMID:34122009 NCBI chr 2:199,449,425...199,487,287
Ensembl chr 2:199,449,345...199,487,290
JBrowse link
G Slc25a5-ps11 solute carrier family 25 member 5, pseudogene 11 increases expression ISO Clozapine results in increased expression of SLC25A6 protein CTD PMID:34122009 NCBI chr18:70,846,358...70,847,597
Ensembl chr18:70,846,358...70,847,597
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Clozapine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186
JBrowse link
G Slc39a7 solute carrier family 39 member 7 increases expression ISO Clozapine results in increased expression of SLC39A7 mRNA CTD PMID:14647396 NCBI chr20:4,824,967...4,828,431
Ensembl chr20:4,824,688...4,828,430
JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO Clozapine results in increased expression of SLC3A2 protein CTD PMID:36482696 NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064
JBrowse link
G Slc6a2 solute carrier family 6 member 2 decreases expression EXP Clozapine results in decreased expression of SLC6A2 mRNA CTD PMID:18923069 NCBI chr19:30,183,289...30,228,292
Ensembl chr19:30,183,383...30,223,348
JBrowse link
G Slc6a3 solute carrier family 6 member 3 affects response to substance ISO SLC6A3 5' UTR affects the susceptibility to Clozapine CTD PMID:20580759 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions
increases expression
affects response to substance
ISO
EXP
[SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapine
Clozapine results in increased expression of SLC6A4
SLC6A4 protein affects the susceptibility to Clozapine
CTD PMID:12007678 PMID:20452607 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases activity ISO Clozapine results in decreased activity of SLCO1B3 protein CTD PMID:39023798 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083
JBrowse link
G Smarcb1 SWI/SNF related BAF chromatin remodeling complex subunit B1 decreases expression ISO Clozapine results in decreased expression of SMARCB1 protein CTD PMID:34122009 NCBI chr20:12,740,105...12,763,054
Ensembl chr20:12,740,943...12,763,055
JBrowse link
G Smarcc2 SWI/SNF related BAF chromatin remodeling complex subunit C2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SMARCC2 protein CTD PMID:34122009 NCBI chr 7:1,466,223...1,494,627
Ensembl chr 7:1,466,454...1,494,626
JBrowse link
G Smc2 structural maintenance of chromosomes 2 decreases expression ISO Clozapine results in decreased expression of SMC2 protein CTD PMID:34122009 NCBI chr 5:71,592,428...71,648,636
Ensembl chr 5:71,602,308...71,648,632
JBrowse link
G Smc3 structural maintenance of chromosomes 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SMC3 protein CTD PMID:34122009 NCBI chr 1:262,606,731...262,649,832
Ensembl chr 1:262,607,080...262,649,825
JBrowse link
G Snap25 synaptosome associated protein 25 increases expression
affects response to substance
EXP
ISO
Clozapine results in increased expression of SNAP25 mRNA
SNAP25 gene SNP affects the susceptibility to Clozapine
CTD PMID:15823421 PMID:15860345 NCBI chr 3:144,494,579...144,576,449
Ensembl chr 3:144,494,595...144,576,448
JBrowse link
G Snrnp200 small nuclear ribonucleoprotein U5 subunit 200 increases expression ISO Clozapine results in increased expression of SNRNP200 protein CTD PMID:34122009 NCBI chr 3:134,882,173...134,911,512
Ensembl chr 3:134,882,173...134,911,500
JBrowse link
G Snrpb small nuclear ribonucleoprotein polypeptides B and B1 increases expression ISO Clozapine results in increased expression of SNRPB protein CTD PMID:34122009 NCBI chr 3:137,824,870...137,832,479
Ensembl chr 3:137,824,683...137,832,515
JBrowse link
G Snrpd2 small nuclear ribonucleoprotein D2 polypeptide increases expression ISO Clozapine results in increased expression of SNRPD2 mRNA CTD PMID:14647396 NCBI chr 1:87,926,030...87,929,259
Ensembl chr 1:87,926,048...87,933,339
Ensembl chr20:87,926,048...87,933,339
JBrowse link
G Snx1 sorting nexin 1 decreases expression ISO Clozapine results in decreased expression of SNX1 protein CTD PMID:34122009 NCBI chr 8:75,515,780...75,565,487
Ensembl chr 8:75,525,181...75,565,561
JBrowse link
G Snx6 sorting nexin 6 increases expression ISO Clozapine results in increased expression of SNX6 protein CTD PMID:34122009 NCBI chr 6:77,966,141...78,009,343
Ensembl chr 6:77,965,819...78,051,290
JBrowse link
G Sod1 superoxide dismutase 1 increases expression
decreases expression
multiple interactions
EXP
ISO
Clozapine results in increased expression of SOD1 mRNA
Clozapine results in decreased expression of SOD1 protein
Clozapine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; Clozapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]
CTD PMID:12111809 PMID:12752374 PMID:16564057 PMID:34122009 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression EXP Clozapine results in decreased expression of SOD2 mRNA CTD PMID:15860345 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Sod3 superoxide dismutase 3 increases expression EXP Clozapine results in increased expression of SOD3 mRNA CTD PMID:15860345 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression
increases expression
EXP Clozapine results in decreased expression of SOS1 mRNA
Clozapine results in increased expression of SOS1 mRNA
CTD PMID:12437575 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO Clozapine results in decreased expression of SPP1 mRNA CTD PMID:17346280 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 decreases expression ISO Clozapine results in decreased expression of SPTLC1 protein CTD PMID:34122009 NCBI chr17:12,029,189...12,068,234
Ensembl chr17:12,029,189...12,068,234
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Clozapine results in increased expression of SQSTM1 protein CTD PMID:36482696 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions
ISO Clozapine results in increased expression of SREBF1 mRNA
Clozapine results in increased expression of SREBF1 mRNA; Clozapine results in increased expression of SREBF1 protein
Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]
CTD PMID:17052361 PMID:19682446 PMID:20564506 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions
increases expression
ISO Clozapine inhibits the reaction [25-hydroxycholesterol results in decreased activity of SREBF2 protein]; Clozapine results in increased cleavage of and results in increased activity of SREBF2 protein
Clozapine results in increased expression of SREBF2 mRNA
CTD PMID:17052361 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943
JBrowse link
G Srrm2 serine/arginine repetitive matrix 2 decreases expression ISO Clozapine results in decreased expression of SRRM2 protein CTD PMID:34122009 NCBI chr10:13,320,059...13,353,337
Ensembl chr10:13,320,059...13,353,337
JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of SRSF2 protein CTD PMID:34122009 NCBI chr10:102,550,962...102,554,200
Ensembl chr10:102,553,072...102,554,141
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 multiple interactions
increases expression
ISO [Cuprizone co-treated with Clozapine] results in increased expression of SRSF5 protein
Clozapine results in increased expression of SRSF5 protein
CTD PMID:34122009 NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:106,336,756...106,341,931
JBrowse link
G Srsf7 serine and arginine rich splicing factor 7 decreases expression ISO Clozapine results in decreased expression of SRSF7 protein CTD PMID:34122009 NCBI chr 6:20,564,035...20,571,205
Ensembl chr 6:20,564,044...20,571,212
JBrowse link
G Ssr3 signal sequence receptor subunit 3 decreases expression ISO Clozapine results in decreased expression of SSR3 protein CTD PMID:34122009 NCBI chr 2:151,915,101...151,935,162
Ensembl chr 2:151,906,149...151,935,170
JBrowse link
G Sst somatostatin multiple interactions EXP Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein] CTD PMID:16567023 NCBI chr11:90,461,546...90,462,823
Ensembl chr11:90,461,546...90,462,823
JBrowse link
G Stim1 stromal interaction molecule 1 decreases expression ISO Clozapine results in decreased expression of STIM1 protein CTD PMID:34122009 NCBI chr 1:166,067,450...166,230,733
Ensembl chr 1:166,067,962...166,233,108
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO Clozapine results in decreased expression of STIP1 protein CTD PMID:34122009 NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:213,638,641...213,657,654
JBrowse link
G Strap serine/threonine kinase receptor associated protein decreases expression ISO Clozapine results in decreased expression of STRAP protein CTD PMID:34122009 NCBI chr 4:172,377,325...172,391,573
Ensembl chr 4:172,377,305...172,392,436
JBrowse link
G Strn4 striatin 4 increases expression ISO Clozapine results in increased expression of STRN4 mRNA CTD PMID:14647396 NCBI chr 1:86,614,193...86,639,959
Ensembl chr 1:86,610,210...86,639,955
JBrowse link
G Stx1a syntaxin 1A increases expression EXP Clozapine results in increased expression of STX1A mRNA CTD PMID:15860345 NCBI chr12:27,278,517...27,306,547
Ensembl chr12:27,278,517...27,306,471
JBrowse link
G Stx1b syntaxin 1B increases expression EXP Clozapine results in increased expression of STX1B mRNA CTD PMID:15860345 NCBI chr 1:191,846,016...191,864,878
Ensembl chr 1:191,833,743...191,871,633
JBrowse link
G Stx4 syntaxin 4 increases expression EXP Clozapine results in increased expression of STX4 mRNA CTD PMID:15860345 NCBI chr 1:191,880,549...191,890,333
Ensembl chr 1:191,881,559...191,896,774
JBrowse link
G Stx8 syntaxin 8 affects expression EXP Clozapine affects the expression of STX8 mRNA CTD PMID:15860345 NCBI chr10:53,154,572...53,393,912
Ensembl chr10:53,153,523...53,429,541
JBrowse link
G Stxbp1 syntaxin binding protein 1 affects expression EXP Clozapine affects the expression of STXBP1 mRNA CTD PMID:12437575 NCBI chr 3:36,474,428...36,536,120
Ensembl chr 3:36,474,428...36,536,058
JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of SUCLA2 protein CTD PMID:34122009 NCBI chr15:55,161,894...55,215,031
Ensembl chr15:55,161,868...55,215,029
JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha decreases expression ISO Clozapine results in decreased expression of SUCLG1 protein CTD PMID:34122009 NCBI chr 4:106,866,329...106,895,686
Ensembl chr 4:106,866,114...106,895,689
JBrowse link
G Supt3h SPT3 homolog, SAGA and STAGA complex component increases expression EXP Clozapine results in increased expression of SUPT3H mRNA CTD PMID:16715494 NCBI chr 9:23,375,889...23,704,229
Ensembl chr 9:23,376,136...23,704,466
JBrowse link
G Syn2 synapsin II decreases expression
increases expression
ISO
EXP
Clozapine results in decreased expression of SYN2 mRNA
Clozapine results in increased expression of SYN2 mRNA
CTD PMID:15860345 PMID:17266109 NCBI chr 4:149,858,919...150,016,845
Ensembl chr 4:149,851,520...150,019,650
JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein decreases expression ISO Clozapine results in decreased expression of SYNCRIP protein CTD PMID:34122009 NCBI chr 8:98,282,358...98,315,412
Ensembl chr 8:98,282,358...98,315,386
JBrowse link
G Syt11 synaptotagmin 11 increases expression EXP Clozapine results in increased expression of SYT11 mRNA CTD PMID:15860345 NCBI chr 2:176,503,845...176,530,354
Ensembl chr 2:176,503,845...176,529,775
JBrowse link
G Syt2 synaptotagmin 2 increases expression ISO Clozapine results in increased expression of SYT2 mRNA CTD PMID:17266109 NCBI chr13:48,639,634...48,749,814
Ensembl chr13:48,639,934...48,749,812
JBrowse link
G Syt4 synaptotagmin 4 increases expression EXP Clozapine results in increased expression of SYT4 mRNA CTD PMID:15860345 NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,312,859...23,320,815
JBrowse link
G Syt5 synaptotagmin 5 decreases expression EXP Clozapine results in decreased expression of SYT5 mRNA CTD PMID:12437575 NCBI chr 1:78,320,034...78,327,750
Ensembl chr 1:78,320,034...78,327,746
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression ISO
EXP
Clozapine results in decreased expression of TAC1 mRNA CTD PMID:10974607 PMID:17266109 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546
JBrowse link
G Tagln transgelin decreases expression ISO Clozapine results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563
JBrowse link
G Tagln2 transgelin 2 decreases expression ISO Clozapine results in decreased expression of TAGLN2 protein CTD PMID:34122009 NCBI chr13:87,499,350...87,506,328
Ensembl chr13:87,499,394...87,506,330
JBrowse link
G Taok2 TAO kinase 2 increases expression ISO Clozapine results in increased expression of TAOK2 protein CTD PMID:34122009 NCBI chr 1:190,906,236...190,925,359
Ensembl chr 1:190,906,239...190,925,140
JBrowse link
G Tatdn1 TatD DNase domain containing 1 increases expression ISO Clozapine results in increased expression of TATDN1 mRNA CTD PMID:14647396 NCBI chr 7:92,339,452...92,370,445
Ensembl chr 7:92,330,554...92,370,400
JBrowse link
G Tbc1d15 TBC1 domain family, member 15 increases expression ISO Clozapine results in increased expression of TBC1D15 protein CTD PMID:36482696 NCBI chr 7:52,690,770...52,746,309
Ensembl chr 7:52,690,770...52,746,303
JBrowse link
G Tbc1d8b TBC1 domain family member 8B increases expression ISO Clozapine results in increased expression of TBC1D8B protein CTD PMID:34122009 NCBI chr  X:108,107,796...108,195,744
Ensembl chr  X:108,107,769...108,195,732
JBrowse link
G Tbcb tubulin folding cofactor B multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TBCB protein CTD PMID:34122009 NCBI chr 1:94,605,100...94,610,949
Ensembl chr 1:94,605,101...94,610,949
JBrowse link
G Tbl3 transducin (beta)-like 3 increases expression ISO Clozapine results in increased expression of TBL3 protein CTD PMID:34122009 NCBI chr10:14,230,660...14,235,873
Ensembl chr10:14,230,661...14,235,873
JBrowse link
G Tcaf1 TRPM8 channel-associated factor 1 decreases expression ISO Clozapine results in decreased expression of TCAF1 protein CTD PMID:34122009 NCBI chr 4:72,589,710...72,639,304
Ensembl chr 4:72,589,710...72,639,475
JBrowse link
G Tes testin LIM domain protein decreases expression ISO Clozapine results in decreased expression of TES protein CTD PMID:34122009 NCBI chr 4:46,331,257...46,369,782
Ensembl chr 4:46,331,257...46,369,780
JBrowse link
G Tgoln2 trans-golgi network protein 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TGOLN2 protein CTD PMID:34122009 NCBI chr 4:106,221,503...106,229,360
Ensembl chr 4:106,221,509...106,229,262
JBrowse link
G Th tyrosine hydroxylase decreases activity
multiple interactions
increases expression
decreases expression
increases activity
EXP
ISO
Clozapine results in decreased activity of TH protein
Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]
Clozapine results in increased expression of TH protein
Clozapine results in decreased expression of TH mRNA; Clozapine results in decreased expression of TH protein
Clozapine results in increased activity of TH protein
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]; [Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine
CTD PMID:12645084 PMID:15983997 PMID:16402076 PMID:16415089 PMID:17028028 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227
JBrowse link
G Thra thyroid hormone receptor alpha decreases expression
increases expression
EXP Clozapine results in decreased expression of THRA mRNA alternative form
Clozapine results in increased expression of THRA mRNA alternative form
CTD PMID:11564422 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657
JBrowse link
G Thrap3 thyroid hormone receptor associated protein 3 decreases expression ISO Clozapine results in decreased expression of THRAP3 protein CTD PMID:34122009 NCBI chr 5:143,729,821...143,772,105
Ensembl chr 5:143,730,596...143,771,983
JBrowse link
G Thrb thyroid hormone receptor beta decreases expression EXP Clozapine results in decreased expression of THRB mRNA alternative form CTD PMID:11564422 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680
JBrowse link
G Tln2 talin 2 decreases expression ISO Clozapine results in decreased expression of TLN2 protein CTD PMID:34122009 NCBI chr 8:76,712,112...77,133,361
Ensembl chr 8:76,712,112...77,133,361
JBrowse link
G Tm9sf2 transmembrane 9 superfamily member 2 decreases expression ISO Clozapine results in decreased expression of TM9SF2 protein CTD PMID:34122009 NCBI chr15:105,606,082...105,660,715
Ensembl chr15:105,606,118...105,660,714
JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 decreases expression ISO Clozapine results in decreased expression of TMED10 protein CTD PMID:34122009 NCBI chr 6:110,722,887...110,757,743
Ensembl chr 6:110,722,889...110,757,777
JBrowse link
G Tmem109 transmembrane protein 109 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of TMEM109 protein CTD PMID:34122009 NCBI chr 1:216,944,516...216,955,091
Ensembl chr 1:216,944,519...216,955,138
JBrowse link
G Tmpo thymopoietin decreases expression ISO Clozapine results in decreased expression of TMPO protein CTD PMID:34122009 NCBI chr 7:27,529,977...27,554,980
Ensembl chr 7:27,529,978...27,554,937
JBrowse link
G Tnf tumor necrosis factor affects response to substance
increases secretion
multiple interactions
increases expression
ISO
EXP
TNF protein affects the susceptibility to Clozapine
Clozapine results in increased secretion of TNF protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of TNF protein]
Clozapine results in increased expression of TNF protein
CTD PMID:20521320 PMID:24709159 PMID:34935985 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnfsf15 TNF superfamily member 15 decreases expression ISO Clozapine results in decreased expression of TNFSF15 mRNA CTD PMID:17346280 NCBI chr 5:82,150,376...82,171,743
Ensembl chr 5:82,150,376...82,171,882
JBrowse link
G Tnik TRAF2 and NCK interacting kinase decreases expression ISO Clozapine results in decreased expression of TNIK mRNA CTD PMID:14647396 NCBI chr 2:113,112,937...113,511,341
Ensembl chr 2:113,112,938...113,511,339
JBrowse link
G Top1mt DNA topoisomerase I mitochondrial increases expression ISO Clozapine results in increased expression of TOP1MT protein CTD PMID:34122009 NCBI chr 7:109,223,269...109,248,855
Ensembl chr 7:109,139,527...109,246,799
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO Clozapine results in increased expression of TP53 mRNA
CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA]
CTD PMID:16160616 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP Clozapine results in increased expression of TPI1 mRNA CTD PMID:15860345 NCBI chr 4:159,301,558...159,305,088
Ensembl chr 4:159,301,562...159,305,413
JBrowse link
G Tpm2 tropomyosin 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TPM2 protein CTD PMID:34122009 NCBI chr 5:62,566,712...62,576,066
Ensembl chr 5:62,566,652...62,575,726
JBrowse link
G Tpm3 tropomyosin 3 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TPM3 protein CTD PMID:34122009 NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:177,814,883...177,842,660
JBrowse link
G Tpm4 tropomyosin 4 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TPM4 protein CTD PMID:34122009 NCBI chr16:17,718,442...17,732,483
Ensembl chr16:17,717,230...17,732,494
JBrowse link
G Tpr translocated promoter region, nuclear basket protein decreases expression ISO Clozapine results in decreased expression of TPR protein CTD PMID:34122009 NCBI chr13:64,974,419...65,037,604
Ensembl chr13:64,974,419...65,037,602
JBrowse link
G Tra2b transformer 2 beta decreases expression ISO Clozapine results in decreased expression of TRA2B protein CTD PMID:34122009 NCBI chr11:92,293,403...92,311,651
Ensembl chr11:92,293,410...92,311,781
JBrowse link
G Trim2 tripartite motif-containing 2 decreases expression ISO Clozapine results in decreased expression of TRIM2 mRNA CTD PMID:14647396 NCBI chr 2:171,798,654...171,950,193
Ensembl chr 2:171,798,660...171,913,468
JBrowse link
G Trim28 tripartite motif-containing 28 decreases expression ISO Clozapine results in decreased expression of TRIM28 protein CTD PMID:34122009 NCBI chr 1:82,724,842...82,731,566
Ensembl chr 1:82,724,838...82,731,572
JBrowse link
G Tspan3 tetraspanin 3 decreases expression
increases expression
ISO Clozapine results in decreased expression of TSPAN3 protein
Clozapine results in increased expression of TSPAN3 protein
CTD PMID:34122009 PMID:36482696 NCBI chr 8:65,442,100...65,465,961
Ensembl chr 8:65,442,101...65,465,844
JBrowse link
G Ttbk1 tau tubulin kinase 1 increases expression ISO Clozapine results in increased expression of TTBK1 protein CTD PMID:34122009 NCBI chr 9:21,990,973...22,035,961
Ensembl chr 9:21,990,973...22,035,961
JBrowse link
G Ttr transthyretin decreases expression
increases expression
ISO
EXP
Clozapine results in decreased expression of TTR mRNA
Clozapine results in increased expression of TTR mRNA; Clozapine results in increased expression of TTR protein
CTD PMID:15927202 PMID:17266109 NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969
JBrowse link
G Ttyh2 tweety family member 2 increases expression ISO Clozapine results in increased expression of TTYH2 protein CTD PMID:34122009 NCBI chr10:100,208,129...100,252,505
Ensembl chr10:100,207,860...100,253,521
JBrowse link
G Tubal3 tubulin, alpha-like 3 increases expression ISO Clozapine results in increased expression of TUBAL3 protein CTD PMID:34122009 NCBI chr17:71,233,194...71,245,297
Ensembl chr17:71,232,851...71,245,337
JBrowse link
G Tubb4b tubulin, beta 4B class IVb multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of TUBB4B protein CTD PMID:34122009 NCBI chr 3:28,435,999...28,438,455
Ensembl chr 3:28,435,148...28,439,719
JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression ISO Clozapine results in increased expression of TUBB protein CTD PMID:34122009 NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726
JBrowse link
G Tubb6 tubulin, beta 6 class V decreases expression ISO Clozapine results in decreased expression of TUBB6 protein CTD PMID:34122009 NCBI chr18:63,213,287...63,222,926
Ensembl chr18:63,213,279...63,224,303
JBrowse link
G Uap1l1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 increases expression ISO Clozapine results in increased expression of UAP1L1 protein CTD PMID:34122009 NCBI chr 3:28,570,854...28,579,766
Ensembl chr 3:28,573,358...28,578,630
JBrowse link
G Uba2 ubiquitin-like modifier activating enzyme 2 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in increased expression of UBA2 protein CTD PMID:34122009 NCBI chr 1:95,912,422...95,939,870
Ensembl chr 1:95,912,430...95,939,901
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 increases expression ISO Clozapine results in increased expression of UBA52 mRNA CTD PMID:14647396 NCBI chr16:18,952,583...18,954,780 JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 affects expression ISO Clozapine affects the expression of UBE2R2 mRNA CTD PMID:14647396 NCBI chr 5:61,082,552...61,141,099
Ensembl chr 5:61,082,552...61,141,452
JBrowse link
G Ubtf upstream binding transcription factor decreases expression ISO Clozapine results in decreased expression of UBTF protein CTD PMID:34122009 NCBI chr10:87,758,346...87,775,377
Ensembl chr10:87,758,346...87,773,088
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO Clozapine results in increased expression of UGT1A1 mRNA CTD PMID:18227147 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein SNP results in increased glucuronidation of Clozapine CTD PMID:15708967 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Unc13a unc-13 homolog A decreases expression EXP Clozapine results in decreased expression of UNC13A mRNA CTD PMID:15860345 NCBI chr16:18,367,891...18,415,808
Ensembl chr16:18,367,919...18,415,899
JBrowse link
G Unc45b unc-45 myosin chaperone B increases expression ISO Clozapine results in increased expression of UNC45B protein CTD PMID:34122009 NCBI chr10:68,343,011...68,370,683
Ensembl chr10:68,343,014...68,370,980
JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI affects expression ISO Clozapine affects the expression of UQCR11 mRNA CTD PMID:14647396 NCBI chr 7:9,955,717...9,960,432
Ensembl chr 7:9,955,764...9,959,047
JBrowse link
G Usp34 ubiquitin specific peptidase 34 increases expression ISO Clozapine results in increased expression of USP34 protein CTD PMID:34122009 NCBI chr14:101,487,110...101,677,519
Ensembl chr14:101,487,153...101,678,632
JBrowse link
G Usp5 ubiquitin specific peptidase 5 increases expression ISO Clozapine results in increased expression of USP5 protein CTD PMID:34122009 NCBI chr 4:159,305,927...159,321,345
Ensembl chr 4:159,305,938...159,320,956
JBrowse link
G Utp18 UTP18 small subunit processome component increases expression ISO Clozapine results in increased expression of UTP18 protein CTD PMID:34122009 NCBI chr10:79,308,785...79,336,241
Ensembl chr10:79,308,787...79,336,197
JBrowse link
G Vamp1 vesicle-associated membrane protein 1 increases expression EXP Clozapine results in increased expression of VAMP1 mRNA CTD PMID:15860345 NCBI chr 4:159,698,894...159,705,582
Ensembl chr 4:159,698,629...159,713,608
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 increases expression EXP Clozapine results in increased expression of VAMP2 mRNA CTD PMID:15860345 NCBI chr10:54,292,423...54,296,657
Ensembl chr10:54,292,806...54,296,654
JBrowse link
G Vapa VAMP associated protein A increases expression ISO Clozapine results in increased expression of VAPA protein CTD PMID:34122009 NCBI chr 9:112,624,791...112,654,731
Ensembl chr 9:112,624,794...112,654,731
JBrowse link
G Vapb VAMP associated protein B and C multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of VAPB protein CTD PMID:34122009 NCBI chr 3:182,954,247...182,997,018
Ensembl chr 3:182,954,240...183,028,619
JBrowse link
G Vcl vinculin increases expression ISO Clozapine results in increased expression of VCL protein CTD PMID:34122009 NCBI chr15:3,315,069...3,404,891
Ensembl chr15:3,315,069...3,405,163
JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression ISO Clozapine results in decreased expression of VDAC1 protein CTD PMID:34122009 NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541
JBrowse link
G Vsnl1 visinin-like 1 decreases expression EXP Clozapine results in decreased expression of VSNL1 mRNA CTD PMID:12437575 NCBI chr 6:39,757,721...39,878,556
Ensembl chr 6:39,757,722...39,878,556
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 multiple interactions ISO [Cuprizone co-treated with Clozapine] results in decreased expression of WARS1 protein CTD PMID:34122009 NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:133,539,744...133,571,645
JBrowse link
G Wbp1l WW domain binding protein 1-like decreases expression ISO Clozapine results in decreased expression of WBP1L mRNA CTD PMID:14647396 NCBI chr 1:255,413,701...255,470,026
Ensembl chr 1:255,413,524...255,470,026
JBrowse link
G Wdr12 WD repeat domain 12 decreases expression ISO Clozapine results in decreased expression of WDR12 protein CTD PMID:34122009 NCBI chr 9:68,969,547...68,996,811
Ensembl chr 9:68,969,547...68,996,811
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Clozapine results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:95,042,451...95,079,679
Ensembl chr10:95,042,441...95,079,293
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta decreases expression ISO Clozapine results in decreased expression of YWHAB mRNA CTD PMID:17266109 NCBI chr 3:173,078,904...173,101,508
Ensembl chr 3:173,079,041...173,101,854
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta increases expression ISO Clozapine results in increased expression of YWHAQ protein CTD PMID:34122009 NCBI chr 6:46,664,358...46,694,875
Ensembl chr 6:46,664,358...46,694,875
JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 decreases expression ISO Clozapine results in decreased expression of ZC3HAV1 protein CTD PMID:34122009 NCBI chr 4:67,979,055...68,029,353
Ensembl chr 4:67,979,055...68,029,353
JBrowse link
diethylcarbamazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actg2 actin gamma 2, smooth muscle multiple interactions EXP diethylcarbamazine inhibits the reaction [ethanol increases expression of alpha SMA protein in liver parenchyma] RGD PMID:28320086 RGD:598130086 NCBI chr 4:117,579,513...117,604,379
Ensembl chr 4:117,579,514...117,604,295
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases activity ISO Diethylcarbamazine results in increased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
JBrowse link
G Il6 interleukin 6 multiple interactions EXP diethylcarbamazine inhibits the reaction [ethanol increases expression of IL6 in liver] RGD PMID:28320086 RGD:598130086 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP diethylcarbamazine inhibits the reaction [ethanol increases expression of TGFbeta1 protein in serum] RGD PMID:28320086 RGD:598130086 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
imatinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddr1 discoidin domain receptor tyrosine kinase 1 decreases phosphorylation ISO imatinib inhibits the reaction [collagen increases autophosphorylation of DDR1 in U2OS cells] RGD PMID:24768818 RGD:151347549 NCBI chr20:3,047,269...3,069,277
Ensembl chr20:3,050,375...3,069,276
JBrowse link
imatinib methanesulfonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp1 LDL receptor related protein 1 decreases expression EXP imatinib mesylate decreases expression of Lrp1 protein in rat INS cells RGD PMID:24865476 RGD:13800516 NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:65,265,639...65,346,196
JBrowse link
levofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 decreases activity ISO Levofloxacin results in decreased activity of ABCC3 protein CTD PMID:39023798 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases activity ISO Levofloxacin results in decreased activity of ABCC4 protein CTD PMID:39023798 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375
JBrowse link
G Abhd1 abhydrolase domain containing 1 decreases expression EXP Levofloxacin results in decreased expression of ABHD1 mRNA CTD PMID:24136188 NCBI chr 6:31,142,476...31,147,464
Ensembl chr 6:31,142,476...31,147,464
JBrowse link
G Acsf2 acyl-CoA synthetase family member 2 decreases expression EXP Levofloxacin results in decreased expression of ACSF2 mRNA CTD PMID:24136188 NCBI chr10:80,001,389...80,043,796
Ensembl chr10:80,001,389...80,045,050
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 decreases expression EXP Levofloxacin results in decreased expression of ACSL5 mRNA CTD PMID:24136188 NCBI chr 1:264,294,851...264,341,943
Ensembl chr 1:264,294,864...264,341,943
JBrowse link
G Actg1 actin, gamma 1 decreases expression EXP Levofloxacin results in decreased expression of ACTG1 mRNA CTD PMID:24136188 NCBI chr10:106,118,106...106,120,951
Ensembl chr10:106,118,108...106,120,951
JBrowse link
G Acy1 aminoacylase 1 decreases expression EXP Levofloxacin results in decreased expression of ACY1 mRNA CTD PMID:24136188 NCBI chr 8:115,951,068...115,956,471
Ensembl chr 8:115,951,068...115,956,405
JBrowse link
G Afp alpha-fetoprotein decreases expression EXP Levofloxacin results in decreased expression of AFP mRNA CTD PMID:24136188 NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression EXP Levofloxacin results in decreased expression of ALDH1B1 mRNA CTD PMID:24136188 NCBI chr 5:64,859,000...64,864,008
Ensembl chr 5:64,858,934...64,864,365
JBrowse link
G Angptl6 angiopoietin-like 6 increases expression EXP Levofloxacin results in increased expression of ANGPTL6 mRNA CTD PMID:24136188 NCBI chr 8:27,689,804...27,696,172
Ensembl chr 8:27,689,806...27,696,111
JBrowse link
G Anxa1 annexin A1 decreases expression EXP Levofloxacin results in decreased expression of ANXA1 mRNA CTD PMID:24136188 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831
JBrowse link
G Anxa2 annexin A2 decreases expression EXP Levofloxacin results in decreased expression of ANXA2 mRNA CTD PMID:24136188 NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:78,986,242...79,022,631
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression EXP Levofloxacin results in decreased expression of AP1S1 mRNA CTD PMID:24136188 NCBI chr12:25,261,958...25,272,483
Ensembl chr12:25,262,036...25,272,483
JBrowse link
G Arl4a ARF like GTPase 4A increases expression EXP Levofloxacin results in increased expression of ARL4A mRNA CTD PMID:24136188 NCBI chr 6:62,809,287...62,811,297
Ensembl chr 6:62,804,548...62,820,760
JBrowse link
G Aspa aspartoacylase decreases expression EXP Levofloxacin results in decreased expression of ASPA mRNA CTD PMID:24136188 NCBI chr10:58,390,204...58,443,790
Ensembl chr10:58,379,410...58,443,769
JBrowse link
G Atg2b autophagy related 2B increases expression EXP Levofloxacin results in increased expression of ATG2B mRNA CTD PMID:24136188 NCBI chr 6:130,286,979...130,357,109
Ensembl chr 6:130,286,986...130,357,109
JBrowse link
G Atp6v0e2 ATPase, H+ transporting V0 subunit e2 decreases expression EXP Levofloxacin results in decreased expression of ATP6V0E2 mRNA CTD PMID:24136188 NCBI chr 4:78,815,771...78,818,919
Ensembl chr 4:78,813,129...78,819,680
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [Levofloxacin co-treated with TNF protein] results in increased expression of BIRC2 mRNA CTD PMID:32035082 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911
JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression ISO Levofloxacin results in decreased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression EXP Levofloxacin results in decreased expression of BST2 mRNA CTD PMID:24136188 NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,251,847...18,254,967
JBrowse link
G Btg1 BTG anti-proliferation factor 1 increases expression EXP Levofloxacin results in increased expression of BTG1 mRNA CTD PMID:24136188 NCBI chr 7:33,228,149...33,230,406
Ensembl chr 7:33,227,833...33,230,406
JBrowse link
G C2cd2 C2 calcium-dependent domain containing 2 decreases expression EXP Levofloxacin results in decreased expression of C2CD2 mRNA CTD PMID:24136188 NCBI chr11:50,694,680...50,759,096
Ensembl chr11:50,694,563...50,759,016
JBrowse link
G C4b complement C4B increases expression EXP Levofloxacin results in increased expression of C4B mRNA CTD PMID:24136188 NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,201,961...4,216,289
JBrowse link
G C5 complement C5 increases expression EXP Levofloxacin results in increased expression of C5 mRNA CTD PMID:24136188 NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:38,668,174...38,759,468
JBrowse link
G C5l1 complement C5 like 1 increases expression EXP Levofloxacin results in increased expression of C5L1 mRNA CTD PMID:24136188 NCBI chr 3:38,799,165...38,818,443
Ensembl chr 3:38,799,731...38,817,527
JBrowse link
G C8h11orf54 similar to human chromosome 11 open reading frame 54 decreases expression EXP Levofloxacin results in decreased expression of C8H11ORF54 mRNA CTD PMID:24136188 NCBI chr 8:20,405,240...20,427,811
Ensembl chr 8:20,405,241...20,427,811
JBrowse link
G C8h11orf65 similar to human chromosome 11 open reading frame 65 increases expression EXP Levofloxacin results in increased expression of C8H11ORF65 mRNA CTD PMID:24136188 NCBI chr 8:62,692,123...62,720,951
Ensembl chr 8:62,692,568...62,720,946
JBrowse link
G Ca14 carbonic anhydrase 14 decreases expression EXP Levofloxacin results in decreased expression of CAR14 mRNA CTD PMID:24136188 NCBI chr 2:186,131,196...186,138,164
Ensembl chr 2:186,129,341...186,138,863
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Levofloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein CTD PMID:30876886 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Ccdc6 coiled-coil domain containing 6 increases expression EXP Levofloxacin results in increased expression of CCDC6 mRNA CTD PMID:24136188 NCBI chr20:18,431,243...18,527,227
Ensembl chr20:18,431,243...18,527,227
JBrowse link
G Ccdc80 coiled-coil domain containing 80 decreases expression EXP Levofloxacin results in decreased expression of CCDC80 mRNA CTD PMID:24136188 NCBI chr11:69,191,188...69,224,844
Ensembl chr11:69,191,189...69,224,844
JBrowse link
G Cd302 CD302 molecule increases expression EXP Levofloxacin results in increased expression of CD302 mRNA CTD PMID:24136188 NCBI chr 3:65,131,017...65,164,737
Ensembl chr 3:65,113,102...65,164,737
JBrowse link
G Cdc42ep4 CDC42 effector protein 4 increases expression EXP Levofloxacin results in increased expression of CDC42EP4 mRNA CTD PMID:24136188 NCBI chr10:99,271,750...99,298,551
Ensembl chr10:99,267,540...99,300,168
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression EXP Levofloxacin results in decreased expression of CDK1 mRNA CTD PMID:24136188 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression EXP Levofloxacin results in decreased expression of CDKN3 mRNA CTD PMID:24136188 NCBI chr15:22,502,299...22,513,725
Ensembl chr15:22,502,382...22,513,722
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression EXP Levofloxacin results in increased expression of CEBPB mRNA CTD PMID:24136188 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072
JBrowse link
G Cfhr1 complement factor H-related 1 increases expression EXP Levofloxacin results in increased expression of CFHR1 mRNA CTD PMID:24136188 NCBI chr13:53,946,298...53,961,282
Ensembl chr13:53,919,927...53,961,303
JBrowse link
G Cgn cingulin decreases expression EXP Levofloxacin results in decreased expression of CGN mRNA CTD PMID:24136188 NCBI chr 2:184,997,425...185,024,785
Ensembl chr 2:184,997,425...185,023,635
JBrowse link
G Chpt1 choline phosphotransferase 1 increases expression EXP Levofloxacin results in increased expression of CHPT1 mRNA CTD PMID:24136188 NCBI chr 7:24,753,880...24,802,529
Ensembl chr 7:24,750,343...24,802,521
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression EXP Levofloxacin results in decreased expression of CKS2 mRNA CTD PMID:24136188 NCBI chr17:13,722,360...13,727,519
Ensembl chr17:13,722,361...13,727,519
JBrowse link
G Clec14a C-type lectin domain containing 14A increases expression EXP Levofloxacin results in increased expression of CLEC14A mRNA CTD PMID:24136188 NCBI chr 6:81,616,414...81,619,556
Ensembl chr 6:81,612,953...81,619,614
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog decreases expression EXP Levofloxacin results in decreased expression of CMBL mRNA CTD PMID:24136188 NCBI chr 2:84,280,128...84,301,878
Ensembl chr 2:84,242,512...84,301,880
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Levofloxacin results in increased expression of CPT1A mRNA CTD PMID:24136188 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression EXP Levofloxacin results in increased expression of CYP27A1 mRNA CTD PMID:24136188 NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Levofloxacin results in decreased activity of CYP3A4 protein CTD PMID:39023798 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 increases expression EXP Levofloxacin results in increased expression of CYP4B1 mRNA CTD PMID:24136188 NCBI chr 5:134,375,807...134,413,635
Ensembl chr 5:134,375,807...134,393,116
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP Levofloxacin results in increased expression of CYP51 mRNA CTD PMID:24136188 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450
JBrowse link
G Ddc dopa decarboxylase decreases expression EXP Levofloxacin results in decreased expression of DDC mRNA CTD PMID:24136188 NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806
JBrowse link
G Ddhd1 DDHD domain containing 1 decreases expression EXP Levofloxacin results in decreased expression of DDHD1 mRNA CTD PMID:24136188 NCBI chr15:21,304,053...21,370,608
Ensembl chr15:21,303,826...21,370,608
JBrowse link
G Dhfr dihydrofolate reductase decreases activity ISO Levofloxacin results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:25,320,895...25,346,004 JBrowse link
G Dnajc9 DnaJ heat shock protein family (Hsp40) member C9 decreases expression EXP Levofloxacin results in decreased expression of DNAJC9 mRNA CTD PMID:24136188 NCBI chr15:3,970,843...4,003,009
Ensembl chr15:3,970,114...3,977,304
JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression EXP Levofloxacin results in decreased expression of DNPH1 mRNA CTD PMID:24136188 NCBI chr 9:21,978,894...21,981,631
Ensembl chr 9:21,978,894...21,981,631
JBrowse link
G Dtymk deoxythymidylate kinase decreases expression EXP Levofloxacin results in decreased expression of DTYMK mRNA CTD PMID:24136188 NCBI chr 9:101,762,899...101,771,733
Ensembl chr 9:101,762,899...101,774,504
JBrowse link
G Dut deoxyuridine triphosphatase decreases expression EXP Levofloxacin results in decreased expression of DUT mRNA CTD PMID:24136188 NCBI chr 3:132,952,258...132,963,433
Ensembl chr 3:132,952,394...132,964,956
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression EXP Levofloxacin results in increased expression of EDEM1 mRNA CTD PMID:24136188 NCBI chr 4:143,350,989...143,385,693
Ensembl chr 4:143,353,624...143,388,060
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 decreases expression EXP Levofloxacin results in decreased expression of ELOVL5 mRNA CTD PMID:24136188 NCBI chr 8:87,671,164...87,737,618
Ensembl chr 8:87,671,159...87,737,616
JBrowse link
G Enc1 ectodermal-neural cortex 1 increases expression EXP Levofloxacin results in increased expression of ENC1 mRNA CTD PMID:24136188 NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:30,283,736...30,315,721
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression EXP Levofloxacin results in decreased expression of EPHX1 mRNA CTD PMID:24136188 NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981
JBrowse link
G Erg28 ergosterol biosynthesis 28 homolog increases expression EXP Levofloxacin results in increased expression of ERG28 mRNA CTD PMID:24136188 NCBI chr 6:111,205,102...111,214,068
Ensembl chr 6:111,205,103...111,214,068
JBrowse link
G Ergic1 endoplasmic reticulum-golgi intermediate compartment 1 decreases expression EXP Levofloxacin results in decreased expression of ERGIC1 mRNA CTD PMID:24136188 NCBI chr10:17,035,615...17,131,411
Ensembl chr10:17,035,615...17,131,376
JBrowse link
G Fgl1 fibrinogen-like 1 increases expression EXP Levofloxacin results in increased expression of FGL1 mRNA CTD PMID:24136188 NCBI chr16:57,824,127...57,854,413
Ensembl chr16:57,824,200...57,854,429
JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 decreases expression EXP Levofloxacin results in decreased expression of FKBP4 mRNA CTD PMID:24136188 NCBI chr 4:163,389,464...163,397,918
Ensembl chr 4:163,389,464...163,397,918
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 increases expression EXP Levofloxacin results in increased expression of FKBP5 mRNA CTD PMID:24136188 NCBI chr20:6,458,931...6,577,227
Ensembl chr20:6,458,940...6,543,118
JBrowse link
G Flna filamin A decreases expression EXP Levofloxacin results in decreased expression of FLNA mRNA CTD PMID:24136188 NCBI chr  X:157,159,051...157,185,559
Ensembl chr  X:157,159,051...157,182,343
JBrowse link
G Fndc3b fibronectin type III domain containing 3B increases expression EXP Levofloxacin results in increased expression of FNDC3B mRNA CTD PMID:24136188 NCBI chr 2:112,240,108...112,546,113
Ensembl chr 2:112,243,202...112,546,306
JBrowse link
G Fzd8 frizzled class receptor 8 increases expression EXP Levofloxacin results in increased expression of FZD8 mRNA CTD PMID:24136188 NCBI chr17:62,007,849...62,015,485
Ensembl chr17:62,007,627...62,015,961
JBrowse link
G Gas6 growth arrest specific 6 increases expression EXP Levofloxacin results in increased expression of GAS6 mRNA CTD PMID:24136188 NCBI chr16:82,747,676...82,778,090
Ensembl chr16:82,747,345...82,778,088
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression EXP Levofloxacin results in decreased expression of GCLC mRNA CTD PMID:24136188 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
JBrowse link
G Glyatl2 glycine-N-acyltransferase-like 2 increases expression EXP Levofloxacin results in increased expression of GLYATL2 mRNA CTD PMID:24136188 NCBI chr 1:219,232,154...219,265,142
Ensembl chr 1:219,232,103...219,266,322
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 decreases expression EXP Levofloxacin results in decreased expression of GPD1 mRNA CTD PMID:24136188 NCBI chr 7:132,722,982...132,730,373
Ensembl chr 7:132,721,915...132,730,368
JBrowse link
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 decreases expression EXP Levofloxacin results in decreased expression of HACD3 mRNA CTD PMID:24136188 NCBI chr 8:74,396,441...74,433,700
Ensembl chr 8:74,396,442...74,433,700
JBrowse link
G Haus4 HAUS augmin-like complex, subunit 4 decreases expression EXP Levofloxacin results in decreased expression of HAUS4 mRNA CTD PMID:24136188 NCBI chr15:31,964,555...31,976,853
Ensembl chr15:31,964,556...31,975,941
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression EXP Levofloxacin results in increased expression of HERPUD1 mRNA CTD PMID:24136188 NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081
JBrowse link
G Hmgb2 high mobility group box 2 decreases expression EXP Levofloxacin results in decreased expression of HMGB2 mRNA CTD PMID:24136188 NCBI chr16:37,721,374...37,723,950
Ensembl chr16:37,721,379...37,723,860
JBrowse link
G Hmgn2 high mobility group nucleosomal binding domain 2 decreases expression EXP Levofloxacin results in decreased expression of HMGN2 mRNA CTD PMID:24136188 NCBI chr 5:151,475,907...151,479,361
Ensembl chr 5:151,475,909...151,479,397
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 decreases expression EXP Levofloxacin results in decreased expression of HTATIP2 mRNA CTD PMID:24136188 NCBI chr 1:108,609,424...108,624,810
Ensembl chr 1:108,605,811...108,624,815
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
ISO Levofloxacin results in decreased expression of ICAM1 mRNA
[Levofloxacin co-treated with TNF protein] results in increased expression of ICAM1 protein
CTD PMID:32035082 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP Levofloxacin results in increased expression of IDI1 mRNA CTD PMID:24136188 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524
JBrowse link
G Ifng interferon gamma increases expression EXP Levofloxacin results in increased expression of IFNG CTD PMID:24136188 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Levofloxacin results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Levofloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein CTD PMID:30876886 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il24 interleukin 24 increases expression ISO Levofloxacin results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Levofloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein CTD PMID:30876886 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Il6r interleukin 6 receptor increases expression EXP Levofloxacin results in increased expression of IL6R mRNA CTD PMID:24136188 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221
JBrowse link
G Ip6k2 inositol hexakisphosphate kinase 2 increases expression EXP Levofloxacin results in increased expression of IP6K2 mRNA CTD PMID:24136188 NCBI chr 8:118,362,154...118,388,668
Ensembl chr 8:118,362,795...118,388,667
JBrowse link
G Ivns1abp influenza virus NS1A binding protein increases expression EXP Levofloxacin results in increased expression of IVNS1ABP mRNA CTD PMID:24136188 NCBI chr13:65,977,069...65,996,685
Ensembl chr13:65,977,045...65,997,547
JBrowse link
G Klf15 KLF transcription factor 15 increases expression EXP Levofloxacin results in increased expression of KLF15 mRNA CTD PMID:24136188 NCBI chr 4:124,522,652...124,535,613
Ensembl chr 4:124,522,909...124,542,373
JBrowse link
G Klf9 KLF transcription factor 9 increases expression EXP Levofloxacin results in increased expression of KLF9 mRNA CTD PMID:24136188 NCBI chr 1:230,126,646...230,151,641
Ensembl chr 1:230,126,646...230,151,641
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression EXP Levofloxacin results in decreased expression of KPNA2 mRNA CTD PMID:24136188 NCBI chr10:92,433,678...92,445,841
Ensembl chr10:92,433,679...92,445,937
JBrowse link
G Kpnb1 karyopherin subunit beta 1 decreases expression EXP Levofloxacin results in decreased expression of KPNB1 mRNA CTD PMID:24136188 NCBI chr10:82,642,082...82,670,856
Ensembl chr10:82,642,082...82,670,856
JBrowse link
G Krt18 keratin 18 decreases expression EXP Levofloxacin results in decreased expression of KRT18 mRNA CTD PMID:24136188 NCBI chr 7:135,036,168...135,039,844
Ensembl chr 7:135,035,982...135,039,848
Ensembl chr10:135,035,982...135,039,848
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Levofloxacin results in increased expression of LBP mRNA CTD PMID:24136188 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 decreases expression EXP Levofloxacin results in decreased expression of LCMT1 mRNA CTD PMID:24136188 NCBI chr 1:187,335,173...187,391,195
Ensembl chr 1:187,327,706...187,391,516
JBrowse link
G Lmnb1 lamin B1 decreases expression EXP Levofloxacin results in decreased expression of LMNB1 mRNA CTD PMID:24136188 NCBI chr18:52,373,939...52,413,284
Ensembl chr18:52,373,757...52,413,283
JBrowse link
G Lmo7 LIM domain 7 decreases expression EXP Levofloxacin results in decreased expression of LMO7 mRNA CTD PMID:24136188 NCBI chr15:84,981,689...85,184,554
Ensembl chr15:84,981,735...85,184,551
JBrowse link
G Lpin1 lipin 1 increases expression EXP Levofloxacin results in increased expression of LPIN1 mRNA CTD PMID:24136188 NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:45,041,522...45,145,991
JBrowse link
G Lurap1l leucine rich adaptor protein 1-like increases expression EXP Levofloxacin results in increased expression of LURAP1L mRNA CTD PMID:24136188 NCBI chr 5:100,402,921...100,455,479
Ensembl chr 5:100,407,483...100,455,478
JBrowse link
G Manba mannosidase beta decreases expression EXP Levofloxacin results in decreased expression of MANBA mRNA CTD PMID:24136188 NCBI chr 2:226,583,968...226,676,520
Ensembl chr 2:226,583,917...226,676,517
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO [TNF protein co-treated with Levofloxacin] results in increased lipidation of MAP1LC3B protein; TNF protein promotes the reaction [Levofloxacin results in increased expression of MAP1LC3B protein] CTD PMID:33609687 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358
JBrowse link
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid increases expression EXP Levofloxacin results in increased expression of MFSD2A mRNA CTD PMID:24136188 NCBI chr 5:140,510,933...140,525,828
Ensembl chr 5:140,510,953...140,525,916
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression EXP Levofloxacin results in increased expression of NAMPT mRNA CTD PMID:24136188 NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:55,151,926...55,189,544
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 decreases expression EXP Levofloxacin results in decreased expression of NEDD9 mRNA CTD PMID:24136188 NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,495,492...23,675,668
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression EXP Levofloxacin results in decreased expression of NFE2L2 mRNA CTD PMID:24136188 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
EXP
ISO
Levofloxacin results in increased expression of NFKBIA mRNA
[Levofloxacin co-treated with TNF protein] results in increased expression of NFKBIA mRNA
CTD PMID:24136188 PMID:32035082 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Nfkbiz NFKB inhibitor zeta increases expression EXP Levofloxacin results in increased expression of NFKBIZ mRNA CTD PMID:24136188 NCBI chr11:58,251,720...58,279,767
Ensembl chr11:58,251,721...58,279,767
JBrowse link
G Nrbp2 nuclear receptor binding protein 2 increases expression EXP Levofloxacin results in increased expression of NRBP2 mRNA CTD PMID:24136188 NCBI chr 7:109,679,330...109,685,656
Ensembl chr 7:109,679,330...109,685,588
JBrowse link
G Nudt4 nudix hydrolase 4 increases expression EXP Levofloxacin results in increased expression of NUDT4 mRNA CTD PMID:24136188 NCBI chr 7:32,074,978...32,091,491
Ensembl chr 7:32,075,002...32,091,491
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP Levofloxacin results in increased expression of NUPR1 mRNA CTD PMID:24136188 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901
JBrowse link
G Omd osteomodulin increases expression EXP Levofloxacin results in increased expression of OMD mRNA CTD PMID:24136188 NCBI chr17:15,266,646...15,274,870
Ensembl chr17:15,266,646...15,274,870
JBrowse link
G Osbpl1a oxysterol binding protein-like 1A decreases expression EXP Levofloxacin results in decreased expression of OSBPL1A mRNA CTD PMID:24136188 NCBI chr18:4,178,734...4,383,511
Ensembl chr18:4,179,631...4,369,421
JBrowse link
G Palmd palmdelphin decreases expression EXP Levofloxacin results in decreased expression of PALMD mRNA CTD PMID:24136188 NCBI chr 2:207,574,413...207,626,239
Ensembl chr 2:207,574,249...207,626,239
JBrowse link
G Pbld1 phenazine biosynthesis-like protein domain containing 1 increases expression EXP Levofloxacin results in increased expression of PBLD1 mRNA CTD PMID:24136188 NCBI chr20:25,549,974...25,565,390
Ensembl chr20:25,549,974...25,565,226
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression
decreases expression
EXP
ISO
Levofloxacin results in increased expression of PID1 mRNA
Levofloxacin results in decreased expression of PID1 mRNA
CTD PMID:24136188 PMID:32816093 NCBI chr 9:92,732,471...92,951,168
Ensembl chr 9:92,734,214...92,750,070
JBrowse link
G Pigu phosphatidylinositol glycan anchor biosynthesis, class U increases expression EXP Levofloxacin results in increased expression of PIGU mRNA CTD PMID:24136188 NCBI chr 3:164,245,011...164,341,444
Ensembl chr 3:164,245,011...164,341,912
JBrowse link
G Pla2g12a phospholipase A2, group XIIA increases expression EXP Levofloxacin results in increased expression of PLA2G12A mRNA CTD PMID:24136188 NCBI chr 2:221,110,722...221,126,966
Ensembl chr 2:221,110,685...221,126,964
JBrowse link
G Plgrkt plasminogen receptor with a C-terminal lysine decreases expression EXP Levofloxacin results in decreased expression of PLGRKT mRNA CTD PMID:24136188 NCBI chr 1:236,512,574...236,526,858
Ensembl chr 1:236,512,580...236,524,840
JBrowse link
G Plin3 perilipin 3 decreases expression EXP Levofloxacin results in decreased expression of PLIN3 mRNA CTD PMID:24136188 NCBI chr 9:1,198,336...1,210,212
Ensembl chr 9:1,198,336...1,210,231
JBrowse link
G Plp2 proteolipid protein 2 decreases expression EXP Levofloxacin results in decreased expression of PLP2 mRNA CTD PMID:24136188 NCBI chr  X:17,506,153...17,509,552
Ensembl chr  X:17,506,059...17,509,550
JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit increases expression EXP Levofloxacin results in increased expression of POLG2 mRNA CTD PMID:24136188 NCBI chr10:92,212,303...92,222,849
Ensembl chr10:92,212,304...92,222,726
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Levofloxacin results in decreased expression of PPARA mRNA CTD PMID:25689681 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase increases expression EXP Levofloxacin results in increased expression of PPCS mRNA CTD PMID:24136188 NCBI chr 5:138,308,394...138,312,047
Ensembl chr 5:138,308,397...138,312,012
JBrowse link
G Ppif peptidylprolyl isomerase F decreases expression EXP Levofloxacin results in decreased expression of PPIF mRNA CTD PMID:24136188 NCBI chr16:1,264,001...1,270,722
Ensembl chr16:1,263,541...1,316,954
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A decreases expression EXP Levofloxacin results in decreased expression of PPP1R14A mRNA CTD PMID:24136188 NCBI chr 1:93,708,269...93,718,218
Ensembl chr 1:93,708,218...93,719,147
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 decreases expression EXP Levofloxacin results in decreased expression of PRKAG2 mRNA CTD PMID:24136188 NCBI chr 4:10,744,695...10,985,939
Ensembl chr 4:10,744,588...10,985,939
JBrowse link
G Proser2 proline and serine rich 2 increases expression EXP Levofloxacin results in increased expression of PROSER2 mRNA CTD PMID:24136188 NCBI chr17:77,061,371...77,096,788
Ensembl chr17:77,077,727...77,095,194
JBrowse link
G Prxl2b peroxiredoxin like 2B increases expression EXP Levofloxacin results in increased expression of PRXL2B mRNA CTD PMID:24136188 NCBI chr 5:170,744,953...170,747,556
Ensembl chr 5:170,744,953...170,747,556
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Levofloxacin results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin decreases expression EXP Levofloxacin results in decreased expression of PTTG1 mRNA CTD PMID:24136188 NCBI chr10:28,394,940...28,406,410
Ensembl chr10:28,394,814...28,406,309
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 increases expression EXP Levofloxacin results in increased expression of RAPGEF4 mRNA CTD PMID:24136188 NCBI chr 3:77,217,024...77,509,933
Ensembl chr 3:77,217,039...77,509,978
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Levofloxacin co-treated with Lipopolysaccharides] affects the localization of RELA protein CTD PMID:32035082 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Retreg1 reticulophagy regulator 1 increases expression EXP Levofloxacin results in increased expression of RETREG1 mRNA CTD PMID:24136188 NCBI chr 2:78,045,435...78,205,316
Ensembl chr 2:78,066,031...78,225,356
JBrowse link
G Rmdn2 regulator of microtubule dynamics 2 decreases expression EXP Levofloxacin results in decreased expression of RMDN2 mRNA CTD PMID:24136188 NCBI chr 6:21,101,383...21,195,221
Ensembl chr 6:21,119,396...21,193,684
JBrowse link
G Rnd2 Rho family GTPase 2 increases expression EXP Levofloxacin results in increased expression of RND2 mRNA CTD PMID:24136188 NCBI chr10:86,899,395...86,902,992
Ensembl chr10:86,899,395...86,902,992
JBrowse link
G Rnf4 ring finger protein 4 decreases expression EXP Levofloxacin results in decreased expression of RNF4 mRNA CTD PMID:24136188 NCBI chr14:80,625,864...80,647,138
Ensembl chr14:80,625,866...80,647,148
JBrowse link
G Rnpepl1 arginyl aminopeptidase like 1 increases expression EXP Levofloxacin results in increased expression of RNPEPL1 mRNA CTD PMID:24136188 NCBI chr 9:100,921,053...100,933,748
Ensembl chr 9:100,923,856...100,933,485
JBrowse link
G Rpa1 replication protein A1 decreases expression EXP Levofloxacin results in decreased expression of RPA1 mRNA CTD PMID:24136188 NCBI chr10:60,647,185...60,698,279
Ensembl chr10:60,647,185...60,698,279
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression EXP Levofloxacin results in decreased expression of RRM2 mRNA CTD PMID:24136188 NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:47,067,690...47,075,370
JBrowse link
G Rsrp1 arginine and serine rich protein 1 decreases expression EXP Levofloxacin results in decreased expression of RSRP1 mRNA CTD PMID:24136188 NCBI chr 5:152,431,448...152,435,202
Ensembl chr 5:152,431,478...152,435,126
JBrowse link
G Rxra retinoid X receptor alpha increases expression EXP Levofloxacin results in increased expression of RXRA mRNA CTD PMID:24136188 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417
JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP Levofloxacin results in increased expression of SC5D mRNA CTD PMID:24136188 NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277
JBrowse link
G Sdc4 syndecan 4 increases expression EXP Levofloxacin results in increased expression of SDC4 mRNA CTD PMID:24136188 NCBI chr 3:173,574,239...173,592,923
Ensembl chr 3:173,574,239...173,593,670
JBrowse link
G Serpina11 serpin family A member 11 increases expression EXP Levofloxacin results in increased expression of SERPINA11 mRNA CTD PMID:24136188 NCBI chr 6:128,668,030...128,677,476
Ensembl chr 6:128,668,034...128,677,454
JBrowse link
G Serpinh1 serpin family H member 1 decreases expression EXP Levofloxacin results in decreased expression of SERPINH1 mRNA CTD PMID:24136188 NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:163,055,630...163,062,976
JBrowse link
G Sesn2 sestrin 2 increases expression EXP Levofloxacin results in increased expression of SESN2 mRNA CTD PMID:24136188 NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255
JBrowse link
G Sfpq splicing factor proline and glutamine rich decreases expression EXP Levofloxacin results in decreased expression of SFPQ mRNA CTD PMID:24136188 NCBI chr 5:144,621,678...144,637,930
Ensembl chr 5:144,622,476...144,637,926
JBrowse link
G Sh3bp5 SH3-domain binding protein 5 increases expression EXP Levofloxacin results in increased expression of SH3BP5 mRNA CTD PMID:24136188 NCBI chr16:6,589,877...6,676,524
Ensembl chr16:6,589,877...6,655,211
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases activity ISO Levofloxacin results in decreased activity of SLC10A1 protein CTD PMID:39023798 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944
JBrowse link
G Slc13a3 solute carrier family 13 member 3 increases expression EXP Levofloxacin results in increased expression of SLC13A3 mRNA CTD PMID:24136188 NCBI chr 3:174,561,174...174,623,893
Ensembl chr 3:174,561,168...174,623,895
JBrowse link
G Slc17a3 solute carrier family 17 member 3 decreases expression EXP Levofloxacin results in decreased expression of SLC17A3 mRNA CTD PMID:24136188 NCBI chr17:41,698,679...41,729,057
Ensembl chr17:41,698,680...41,723,329
JBrowse link
G Slc38a2 solute carrier family 38, member 2 increases expression EXP Levofloxacin results in increased expression of SLC38A2 mRNA CTD PMID:24136188 NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Levofloxacin results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases activity ISO Levofloxacin results in decreased activity of SLCO1B3 protein CTD PMID:39023798 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO Levofloxacin results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822
JBrowse link
G Spa17 sperm autoantigenic protein 17 decreases expression EXP Levofloxacin results in decreased expression of SPA17 mRNA CTD PMID:24136188 NCBI chr 8:45,496,175...45,507,262
Ensembl chr 8:45,496,175...45,507,262
JBrowse link
G Srxn1 sulfiredoxin 1 decreases expression EXP Levofloxacin results in decreased expression of SRXN1 mRNA CTD PMID:24136188 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765
JBrowse link
G Ssx2ip SSX family member 2 interacting protein decreases expression EXP Levofloxacin results in decreased expression of SSX2IP mRNA CTD PMID:24136188 NCBI chr 2:237,958,286...237,991,026
Ensembl chr 2:237,958,465...237,991,017
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP Levofloxacin results in increased expression of STAT3 mRNA CTD PMID:24136188 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
JBrowse link
G Steap3 STEAP3 metalloreductase decreases expression EXP Levofloxacin results in decreased expression of STEAP3 mRNA CTD PMID:24136188 NCBI chr13:33,904,710...33,950,100
Ensembl chr13:33,904,710...33,950,080
JBrowse link
G Stmn1 stathmin 1 decreases expression EXP Levofloxacin results in decreased expression of STMN1 mRNA CTD PMID:24136188 NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:151,964,351...151,970,842
JBrowse link
G Sumf1 sulfatase modifying factor 1 increases expression EXP Levofloxacin results in increased expression of SUMF1 mRNA CTD PMID:24136188 NCBI chr 4:142,634,766...142,716,726
Ensembl chr 4:142,634,767...142,716,712
JBrowse link
G Synrg synergin, gamma increases expression EXP Levofloxacin results in increased expression of SYNRG mRNA CTD PMID:24136188 NCBI chr10:69,346,154...69,428,714
Ensembl chr10:69,322,114...69,428,714
JBrowse link
G Syvn1 synoviolin 1 increases expression EXP Levofloxacin results in increased expression of SYVN1 mRNA CTD PMID:24136188 NCBI chr 1:212,766,736...212,775,426
Ensembl chr 1:212,768,907...212,776,457
JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 decreases expression EXP Levofloxacin results in decreased expression of TCIRG1 mRNA CTD PMID:24136188 NCBI chr 1:210,556,270...210,568,021
Ensembl chr 1:210,556,270...210,568,033
JBrowse link
G Tef TEF transcription factor, PAR bZIP family member increases expression EXP Levofloxacin results in increased expression of TEF mRNA CTD PMID:24136188 NCBI chr 7:115,197,180...115,221,930
Ensembl chr 7:115,193,282...115,221,928
JBrowse link
G Tjp2 tight junction protein 2 decreases expression EXP Levofloxacin results in decreased expression of TJP2 mRNA CTD PMID:24136188 NCBI chr 1:231,136,218...231,264,750
Ensembl chr 1:231,136,243...231,264,750
JBrowse link
G Tkt transketolase decreases expression EXP Levofloxacin results in decreased expression of TKT mRNA CTD PMID:24136188 NCBI chr16:5,729,381...5,755,170
Ensembl chr16:5,729,991...5,756,431
JBrowse link
G Tmem176b transmembrane protein 176B increases expression EXP Levofloxacin results in increased expression of TMEM176B mRNA CTD PMID:24136188 NCBI chr 4:79,097,808...79,105,263
Ensembl chr 4:79,097,808...79,105,263
JBrowse link
G Tmem38b transmembrane protein 38B increases expression EXP Levofloxacin results in increased expression of TMEM38B mRNA CTD PMID:24136188 NCBI chr 5:73,255,662...73,291,383
Ensembl chr 5:73,255,632...73,292,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Levofloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Levofloxacin co-treated with TNF protein] results in increased expression of ICAM1 protein; [Levofloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 mRNA; [TNF protein co-treated with Levofloxacin] results in increased lipidation of MAP1LC3B protein; TNF protein promotes the reaction [Levofloxacin results in increased expression of MAP1LC3B protein]
[Levofloxacin co-treated with TNF protein] results in increased expression of BIRC2 mRNA; [Levofloxacin co-treated with TNF protein] results in increased expression of ICAM1 protein; [Levofloxacin co-treated with TNF protein] results in increased expression of NFKBIA mRNA; [Levofloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 mRNA
CTD PMID:30876886 PMID:32035082 PMID:33609687 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO [Levofloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 mRNA CTD PMID:32035082 NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 decreases expression ISO Levofloxacin results in decreased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:56,911,252...56,930,796
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 decreases expression EXP Levofloxacin results in decreased expression of TNFRSF9 mRNA CTD PMID:24136188 NCBI chr 5:166,664,494...166,690,834
Ensembl chr 5:166,664,494...166,690,831
JBrowse link
G Tob2 transducer of ERBB2, 2 increases expression EXP Levofloxacin results in increased expression of TOB2 mRNA CTD PMID:24136188 NCBI chr 7:115,242,843...115,251,563
Ensembl chr 7:115,239,895...115,258,155
JBrowse link
G Tpm3 tropomyosin 3 decreases expression EXP Levofloxacin results in decreased expression of TPM3 mRNA CTD PMID:24136188 NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:177,814,883...177,842,660
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 increases expression EXP Levofloxacin results in increased expression of TSC22D3 mRNA CTD PMID:24136188 NCBI chr  X:109,006,410...109,066,389
Ensembl chr  X:109,006,420...109,015,519
JBrowse link
G Tstd3 thiosulfate sulfurtransferase like domain containing 3 decreases expression EXP Levofloxacin results in decreased expression of TSTD3 mRNA CTD PMID:24136188 NCBI chr 5:40,091,438...40,101,509
Ensembl chr 5:40,065,807...40,100,878
JBrowse link
G Tuba1c tubulin, alpha 1C decreases expression EXP Levofloxacin results in decreased expression of TUBA1C mRNA CTD PMID:24136188 NCBI chr 7:131,636,974...132,078,589
Ensembl chr 7:132,070,536...132,079,311
JBrowse link
G Tubb4b tubulin, beta 4B class IVb decreases expression EXP Levofloxacin results in decreased expression of TUBB4B mRNA CTD PMID:24136188 NCBI chr 3:28,435,999...28,438,455
Ensembl chr 3:28,435,148...28,439,719
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression EXP Levofloxacin results in decreased expression of TUBB5 mRNA CTD PMID:24136188 NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726
JBrowse link
G Tubb6 tubulin, beta 6 class V decreases expression EXP Levofloxacin results in decreased expression of TUBB6 mRNA CTD PMID:24136188 NCBI chr18:63,213,287...63,222,926
Ensembl chr18:63,213,279...63,224,303
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO Levofloxacin results in decreased activity of UGT1A3 protein CTD PMID:39023798 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 decreases activity ISO Levofloxacin results in decreased activity of UGT2B7 protein CTD PMID:39023798 NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451
JBrowse link
G Usp2 ubiquitin specific peptidase 2 increases expression EXP Levofloxacin results in increased expression of USP2 mRNA CTD PMID:24136188 NCBI chr 8:53,308,264...53,336,800
Ensembl chr 8:53,308,303...53,336,794
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP Levofloxacin results in increased expression of VCAM1 mRNA CTD PMID:24136188 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
JBrowse link
G Vim vimentin decreases expression EXP Levofloxacin results in decreased expression of VIM mRNA CTD PMID:24136188 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression EXP Levofloxacin results in increased expression of VMP1 mRNA CTD PMID:24136188 NCBI chr10:71,903,223...72,002,337
Ensembl chr10:71,903,227...72,002,319
JBrowse link
G Wasl WASP like actin nucleation promoting factor increases expression EXP Levofloxacin results in increased expression of WASL mRNA CTD PMID:24136188 NCBI chr 4:54,049,081...54,097,653
Ensembl chr 4:54,049,082...54,097,570
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression EXP Levofloxacin results in increased expression of WIPI1 mRNA CTD PMID:24136188 NCBI chr10:95,042,451...95,079,679
Ensembl chr10:95,042,441...95,079,293
JBrowse link
G Xpo1 exportin 1 decreases expression EXP Levofloxacin results in decreased expression of XPO1 mRNA CTD PMID:24136188 NCBI chr14:101,434,450...101,476,705
Ensembl chr14:101,434,517...101,476,714
JBrowse link
G Zfp354a zinc finger protein 354A increases expression EXP Levofloxacin results in increased expression of ZFP354A mRNA CTD PMID:24136188 NCBI chr10:35,897,217...35,909,063
Ensembl chr10:35,897,228...35,909,510
JBrowse link
G Zfp446 zinc finger protein 446 increases expression EXP Levofloxacin results in increased expression of ZFP446 mRNA CTD PMID:24136188 NCBI chr 1:82,673,920...82,680,414
Ensembl chr 1:82,673,918...82,685,430
JBrowse link
ofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Ofloxacin results in decreased activity of ABCB11 protein
Ofloxacin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:24014644 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581
JBrowse link
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO Ofloxacin affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr 7:10,325,515...10,340,955
Ensembl chr 7:10,325,539...10,341,890
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Ofloxacin results in increased expression of ASAH1 mRNA CTD PMID:17175557 NCBI chr16:57,669,927...57,701,349
Ensembl chr16:57,669,750...57,718,305
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP1A2 protein results in increased metabolism of Theophylline] CTD PMID:11408986 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP3A4 protein results in increased metabolism of Theophylline] CTD PMID:11408986 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Ofloxacin results in increased expression of DEPP1 mRNA CTD PMID:17175557 NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:151,581,502...151,586,233
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Ofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA] CTD PMID:16148020 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Ins1 insulin 1 increases expression EXP Ofloxacin results in increased expression of INS1 protein CTD PMID:17026994 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO Ofloxacin results in decreased expression of ITGB4 protein CTD PMID:14687228 NCBI chr10:101,705,592...101,741,933
Ensembl chr10:101,705,587...101,741,932
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO Ofloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases expression
ISO Ofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Ofloxacin results in decreased expression of MMP13 mRNA
CTD PMID:16148020 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression EXP Ofloxacin results in increased expression of MMP3 mRNA CTD PMID:20688128 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Ofloxacin results in increased expression of NUPR1 mRNA CTD PMID:17175557 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Ofloxacin results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase decreases expression ISO Ofloxacin results in decreased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:78,238,747...78,255,645
Ensembl chr17:78,238,747...78,255,645
JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression EXP Ofloxacin results in increased expression of PLAUR mRNA CTD PMID:20688128 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Ofloxacin results in increased expression of PTGS2 mRNA CTD PMID:20688128 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 affects expression ISO Ofloxacin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:4,872,720...4,876,425 JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO
EXP
Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:16928358 NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077
JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects localization
decreases expression
ISO Ofloxacin affects the localization of SLC2A1 mRNA
Ofloxacin results in decreased expression of SLC2A1 mRNA
CTD PMID:19022360 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression EXP Ofloxacin results in increased expression of TNFRSF12A mRNA CTD PMID:20688128 NCBI chr10:13,211,670...13,213,666
Ensembl chr10:13,211,673...13,213,704
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Ofloxacin CTD PMID:15769885 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Ofloxacin CTD PMID:15769885 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Ofloxacin CTD PMID:15769885 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
olanzapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A1bg alpha-1-B glycoprotein affects phosphorylation ISO olanzapine affects the phosphorylation of A1BG protein CTD PMID:25821032 NCBI chr 7:94,383,333...94,387,922
Ensembl chr 7:94,383,333...94,387,496
JBrowse link
G A2m alpha-2-macroglobulin affects phosphorylation ISO olanzapine affects the phosphorylation of A2M protein CTD PMID:25821032 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:156,569,860...156,619,868
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO olanzapine results in decreased activity of ABCB11 protein CTD PMID:22646477 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions
ISO
EXP
olanzapine results in decreased activity of ABCB1 protein
[[ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] affects the susceptibility to Fluoxetine] which affects the abundance of Olanzapine; [[ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] affects the susceptibility to Fluoxetine] which results in increased uptake of Olanzapine; [ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] results in increased abundance of and results in decreased uptake of Olanzapine
CTD PMID:16810505 PMID:34610281 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B multiple interactions EXP [[ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] affects the susceptibility to Fluoxetine] which affects the abundance of Olanzapine; [[ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] affects the susceptibility to Fluoxetine] which results in increased uptake of Olanzapine; [ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] results in increased abundance of and results in decreased uptake of Olanzapine CTD PMID:34610281 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO olanzapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] CTD PMID:18834354 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493
JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression
multiple interactions
ISO Olanzapine results in decreased expression of ACACA mRNA
capsazepine inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]
CTD PMID:32652086 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA CTD PMID:23226405 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136
JBrowse link
G Adcyap1r1 ADCYAP receptor type I affects expression ISO olanzapine affects the expression of ADCYAP1R1 mRNA CTD PMID:27900577 NCBI chr 4:85,924,171...85,972,973
Ensembl chr 4:85,924,100...85,972,973
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
decreases expression
increases expression
ISO capsazepine inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]; Metformin inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]
olanzapine results in increased expression of ADIPOQ mRNA
CTD PMID:17651982 PMID:32652086 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169
JBrowse link
G Afm afamin affects phosphorylation ISO olanzapine affects the phosphorylation of AFM protein CTD PMID:25821032 NCBI chr14:17,815,194...17,848,042
Ensembl chr14:17,815,194...17,848,039
JBrowse link
G Agrp agouti related neuropeptide increases expression
multiple interactions
EXP
ISO
olanzapine results in increased expression of AGRP protein
Metformin inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA]
CTD PMID:21695181 PMID:32652086 NCBI chr19:50,357,899...50,396,758
Ensembl chr19:50,357,905...50,358,698
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
decreases expression
multiple interactions
increases response to substance
increases phosphorylation
ISO Olanzapine results in increased expression of AKT1 mRNA; Olanzapine results in increased expression of AKT1 protein
Olanzapine results in decreased expression of AKT1 mRNA
capsazepine inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]
AKT1 gene SNP results in increased susceptibility to olanzapine
olanzapine results in increased phosphorylation of AKT1 protein
CTD PMID:19440698 PMID:21187413 PMID:32652086 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Alb albumin affects phosphorylation ISO olanzapine affects the phosphorylation of ALB protein CTD PMID:25821032 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
JBrowse link
G Apoa1 apolipoprotein A1 increases phosphorylation ISO olanzapine results in increased phosphorylation of APOA1 protein CTD PMID:25821032 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729
JBrowse link
G Apoa4 apolipoprotein A4 affects phosphorylation ISO olanzapine affects the phosphorylation of APOA4 protein CTD PMID:25821032 NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164
JBrowse link
G Apob apolipoprotein B increases phosphorylation ISO olanzapine results in increased phosphorylation of APOB protein CTD PMID:25821032 NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814
JBrowse link
G Apoc3 apolipoprotein C3 affects response to substance EXP APOC3 gene polymorphism affects the susceptibility to olanzapine CTD PMID:17726453 NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:55,428,024...55,458,679
JBrowse link
G Apoh apolipoprotein H affects phosphorylation ISO olanzapine affects the phosphorylation of APOH protein CTD PMID:25821032 NCBI chr10:93,841,992...93,855,897
Ensembl chr10:93,841,966...93,857,127
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP olanzapine inhibits the reaction [APP protein modified form affects the activity of CAT protein]; olanzapine inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species] CTD PMID:15948179 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
JBrowse link
G Aqp4 aquaporin 4 affects response to substance
increases response to substance
ISO AQP4 gene polymorphism affects the susceptibility to olanzapine
AQP4 protein results in increased susceptibility to olanzapine
CTD PMID:22544010 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP olanzapine results in increased expression of BAX protein CTD PMID:16462815 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
EXP olanzapine inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]
olanzapine results in increased expression of BCL2 mRNA; olanzapine results in increased expression of BCL2 protein
CTD PMID:15126120 PMID:15276877 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP
ISO
olanzapine results in increased expression of BDNF mRNA; olanzapine results in increased expression of BDNF protein
Olanzapine results in increased expression of BDNF mRNA; Olanzapine results in increased expression of BDNF protein
CTD PMID:12478621 PMID:17442489 PMID:29182611 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
JBrowse link
G Bik BCL2-interacting killer increases expression ISO olanzapine results in increased expression of BIK mRNA CTD PMID:16160616 NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:116,552,303...116,571,317
JBrowse link
G C3 complement C3 affects phosphorylation ISO olanzapine affects the phosphorylation of C3 protein CTD PMID:25821032 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339
JBrowse link
G C4a complement C4A decreases phosphorylation ISO olanzapine results in decreased phosphorylation of C4A protein CTD PMID:25821032 NCBI chr20:4,010,306...4,024,707 JBrowse link
G C4b complement C4B affects phosphorylation ISO olanzapine affects the phosphorylation of C4B protein CTD PMID:25821032 NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,201,961...4,216,289
JBrowse link
G C5 complement C5 affects phosphorylation ISO olanzapine affects the phosphorylation of C5 protein CTD PMID:25821032 NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:38,668,174...38,759,468
JBrowse link
G C6 complement C6 affects phosphorylation ISO olanzapine affects the phosphorylation of C6 protein CTD PMID:25821032 NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:55,573,653...55,649,120
JBrowse link
G C9 complement C9 affects phosphorylation ISO olanzapine affects the phosphorylation of C9 protein CTD PMID:25821032 NCBI chr 2:57,300,510...57,348,759
Ensembl chr 2:57,300,427...57,348,752
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP olanzapine results in decreased expression of and results in decreased phosphorylation of CAMK2A protein CTD PMID:18061412 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504
JBrowse link
G Cat catalase multiple interactions EXP olanzapine inhibits the reaction [APP protein modified form affects the activity of CAT protein] CTD PMID:15948179 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Cfb complement factor B affects phosphorylation ISO olanzapine affects the phosphorylation of CFB protein CTD PMID:25821032 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740
JBrowse link
G Cfh complement factor H decreases phosphorylation ISO olanzapine results in decreased phosphorylation of CFH protein CTD PMID:25821032 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:54,062,531...54,164,532
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 affects binding ISO olanzapine binds to CHRM1 protein CTD PMID:16983399 NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602
JBrowse link
G Clu clusterin affects phosphorylation ISO olanzapine affects the phosphorylation of CLU protein CTD PMID:25821032 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases phosphorylation ISO olanzapine results in decreased phosphorylation of COL1A1 protein CTD PMID:25821032 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460
JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP olanzapine results in increased expression of COMT mRNA CTD PMID:15964593 NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533
JBrowse link
G Cp ceruloplasmin affects phosphorylation ISO olanzapine affects the phosphorylation of CP protein CTD PMID:25821032 NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions EXP [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of CPT2 mRNA; [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA CTD PMID:23226405 NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:127,893,207...127,910,818
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP [Fluoxetine co-treated with olanzapine] results in decreased phosphorylation of CREB1 protein CTD PMID:14556240 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
JBrowse link
G Cs citrate synthase increases activity
multiple interactions
EXP Olanzapine results in increased activity of CS protein
[Olanzapine co-treated with Fluoxetine] results in increased activity of CS protein
CTD PMID:20971158 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
increases expression
multiple interactions
ISO olanzapine results in decreased expression of CTNNB1 mRNA
Olanzapine results in increased expression of CTNNB1 mRNA
Olanzapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]
CTD PMID:18797397 PMID:31563592 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
multiple interactions
ISO CYP1A2 protein affects the metabolism of olanzapine
Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of olanzapine]
CTD PMID:15545309 PMID:15883149 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Olanzapine results in decreased activity of CYP3A4 protein CTD PMID:39023798 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Dab1 DAB adaptor protein 1 decreases expression EXP olanzapine results in decreased expression of DAB1 protein CTD PMID:19359144 NCBI chr 5:123,621,510...124,742,585
Ensembl chr 5:124,369,415...124,742,584
JBrowse link
G Dclk1 doublecortin-like kinase 1 increases expression ISO olanzapine results in increased expression of DCLK1 mRNA CTD PMID:18797397 NCBI chr 2:141,567,215...141,861,088
Ensembl chr 2:141,571,983...141,861,090
JBrowse link
G Drd1 dopamine receptor D1 affects binding ISO olanzapine binds to DRD1 protein CTD PMID:24389121 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166
JBrowse link
G Drd2 dopamine receptor D2 increases response to substance
multiple interactions
decreases activity
affects binding
affects activity
ISO
EXP
DRD2 gene SNP results in increased susceptibility to olanzapine; DRD2 intron SNP results in increased susceptibility to olanzapine
olanzapine promotes the reaction [Dopamine binds to DRD2 protein]
olanzapine results in decreased activity of DRD2 protein
olanzapine binds to DRD2 protein
olanzapine affects the activity of DRD2 protein
CTD PMID:10482380 PMID:10831489 PMID:11198054 PMID:15716360 PMID:20361897 More... NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO DRD3 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine] CTD PMID:20021991 NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760
JBrowse link
G F2 coagulation factor II, thrombin affects phosphorylation ISO olanzapine affects the phosphorylation of F2 protein CTD PMID:25821032 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Olanzapine results in increased expression of FABP1 mRNA CTD PMID:31437515 NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113
JBrowse link
G Fasn fatty acid synthase increases expression ISO olanzapine results in increased expression of FASN mRNA CTD PMID:17651982 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP [Fluoxetine co-treated with olanzapine] results in increased expression of FGF2 mRNA CTD PMID:15158429 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493
JBrowse link
G Fn1 fibronectin 1 affects phosphorylation ISO olanzapine affects the phosphorylation of FN1 protein CTD PMID:25821032 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Fluoxetine co-treated with olanzapine] results in decreased expression of FOS protein CTD PMID:14556240 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions EXP olanzapine inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOSL1 protein] CTD PMID:11425506 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391
JBrowse link
G Gad1 glutamate decarboxylase 1 decreases expression EXP olanzapine results in decreased expression of GAD1 mRNA; olanzapine results in decreased expression of GAD1 protein CTD PMID:14519413 PMID:19359144 NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759
JBrowse link
G Gad2 glutamate decarboxylase 2 decreases expression EXP olanzapine results in decreased expression of GAD2 protein CTD PMID:19359144 NCBI chr17:89,671,718...89,734,246
Ensembl chr17:89,671,716...89,941,089
JBrowse link
G Gc GC, vitamin D binding protein affects phosphorylation ISO olanzapine affects the phosphorylation of GC protein CTD PMID:25821032 NCBI chr14:18,916,255...18,951,670
Ensembl chr14:18,916,246...18,951,673
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Olanzapine results in increased expression of GCLC mRNA CTD PMID:37005277 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression
ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA] CTD PMID:32652086 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions
increases expression
ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of GHRL protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of GHRL protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHRL protein] CTD PMID:32652086 NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:148,421,315...148,425,969
JBrowse link
G Ghsr growth hormone secretagogue receptor increases expression
multiple interactions
ISO Olanzapine results in increased expression of GHSR mRNA
capsazepine inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]
CTD PMID:32652086 NCBI chr 2:112,196,158...112,201,666
Ensembl chr 2:112,196,767...112,201,181
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression
ISO Dietary Fats promotes the reaction [Olanzapine results in increased expression of GPT protein] CTD PMID:37019375 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases expression EXP olanzapine results in increased expression of GRIA2 mRNA CTD PMID:11526992 NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:168,247,496...168,367,616
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression EXP olanzapine results in increased expression of GRIA3 mRNA CTD PMID:11526992 NCBI chr  X:125,103,975...125,369,690
Ensembl chr  X:125,103,782...125,369,679
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
decreases expression
ISO olanzapine results in increased phosphorylation of GSK3B protein
Olanzapine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]
Olanzapine results in decreased expression of GSK3B mRNA
CTD PMID:19440698 PMID:31563592 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression
decreases expression
multiple interactions
ISO
EXP
olanzapine results in increased expression of HMGCR mRNA
olanzapine results in decreased expression of HMGCR mRNA
1-(carboxymethylthio)tetradecane promotes the reaction [olanzapine results in decreased expression of HMGCR mRNA]; olanzapine promotes the reaction [1-(carboxymethylthio)tetradecane results in decreased expression of HMGCR mRNA]
CTD PMID:17052361 PMID:23226405 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO olanzapine results in increased expression of HMGCS1 mRNA CTD PMID:17052361 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Olanzapine results in increased expression of HMOX1 mRNA CTD PMID:37005277 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hpx hemopexin affects phosphorylation ISO olanzapine affects the phosphorylation of HPX protein CTD PMID:25821032 NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:169,344,583...169,352,156
JBrowse link
G Hrg histidine-rich glycoprotein affects phosphorylation ISO olanzapine affects the phosphorylation of HRG protein CTD PMID:25821032 NCBI chr11:91,559,087...91,573,982
Ensembl chr11:91,559,091...91,573,982
JBrowse link
G Hrh1 histamine receptor H 1 affects binding
multiple interactions
ISO olanzapine binds to HRH1 protein
HRH1 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine]
CTD PMID:16983399 PMID:20021991 PMID:24389121 NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
affects binding
decreases activity
ISO
EXP
olanzapine binds to and results in decreased activity of HTR2A protein
olanzapine binds to HTR2A protein
olanzapine results in decreased activity of HTR2A protein
[[olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in decreased activity of HTR2A protein]; [olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; olanzapine binds to and results in decreased activity of HTR2A protein
CTD PMID:16983399 PMID:18976543 PMID:19304867 PMID:20521326 PMID:24389121 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C increases response to substance
affects binding
affects response to substance
ISO HTR2C gene polymorphism results in increased susceptibility to olanzapine
olanzapine binds to HTR2C protein
HTR2C gene polymorphism affects the susceptibility to Olanzapine; HTR2C gene SNP affects the susceptibility to Olanzapine; HTR2C protein affects the susceptibility to Olanzapine
CTD PMID:15666332 PMID:16983399 PMID:19142110 PMID:19434072 PMID:24389121 NCBI chr  X:115,453,190...115,682,325
Ensembl chr  X:115,452,842...115,682,324
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 affects binding ISO olanzapine binds to HTR6 protein CTD PMID:16983399 NCBI chr 5:156,579,901...156,595,147
Ensembl chr 5:156,579,901...156,595,147
JBrowse link
G Il10 interleukin 10 increases expression
decreases expression
multiple interactions
ISO Olanzapine results in increased expression of IL10 mRNA
Olanzapine results in decreased expression of IL10 protein
Lithium inhibits the reaction [Olanzapine results in decreased expression of IL10 protein]
CTD PMID:30695037 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO Lithium inhibits the reaction [Olanzapine results in increased expression of IL1B mRNA]; Lithium inhibits the reaction [Olanzapine results in increased expression of IL1B protein]
Olanzapine results in increased expression of IL1B mRNA; Olanzapine results in increased expression of IL1B protein
CTD PMID:30695037 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of IL6 protein]; Lithium inhibits the reaction [Olanzapine results in increased expression of IL6 mRNA]; Lithium inhibits the reaction [Olanzapine results in increased expression of IL6 protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of IL6 protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of IL6 protein]
Olanzapine results in increased expression of IL6 mRNA; Olanzapine results in increased expression of IL6 protein
CTD PMID:30695037 PMID:32652086 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Ins2 insulin 2 increases secretion
increases expression
ISO olanzapine results in increased secretion of INS protein
olanzapine results in increased expression of INS protein
CTD PMID:11769361 PMID:11927762 PMID:16601995 PMID:19512971 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805
JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 affects phosphorylation ISO olanzapine affects the phosphorylation of ITIH2 protein CTD PMID:25821032 NCBI chr17:73,285,281...73,321,555
Ensembl chr17:73,285,270...73,321,547
JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 affects phosphorylation ISO olanzapine affects the phosphorylation of ITIH4 protein CTD PMID:25821032 NCBI chr16:6,086,985...6,102,162
Ensembl chr16:6,086,973...6,102,160
JBrowse link
G Jak2 Janus kinase 2 multiple interactions
increases activity
EXP [[olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in decreased activity of HTR2A protein]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in increased expression of RGS7 mRNA]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in increased expression of RGS7 protein]; [olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein
olanzapine results in increased activity of JAK2 protein
CTD PMID:18976543 PMID:19304867 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762
JBrowse link
G Kcna1 potassium voltage-gated channel subfamily A member 1 increases expression ISO olanzapine results in increased expression of KCNA1 mRNA CTD PMID:18797397 NCBI chr 4:161,150,378...161,160,051
Ensembl chr 4:161,147,418...161,160,044
JBrowse link
G Kcnab1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 decreases expression ISO olanzapine results in decreased expression of KCNAB1 mRNA CTD PMID:18797397 NCBI chr 2:151,446,975...151,913,636
Ensembl chr 2:151,446,947...151,913,636
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
ISO olanzapine results in decreased activity of KCNH2 protein
olanzapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
CTD PMID:16494862 PMID:21158687 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421
JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 decreases expression ISO olanzapine results in decreased expression of KCNIP3 mRNA; olanzapine results in decreased expression of KCNIP3 protein CTD PMID:18797397 NCBI chr 3:135,130,331...135,196,031
Ensembl chr 3:135,132,119...135,196,216
JBrowse link
G Klc1 kinesin light chain 1 decreases expression ISO olanzapine results in decreased expression of KLC1 mRNA CTD PMID:18797397 NCBI chr 6:136,644,592...136,690,399
Ensembl chr 6:136,644,307...136,689,760
JBrowse link
G Kng1 kininogen 1 affects phosphorylation ISO Olanzapine affects the phosphorylation of KNG1 protein CTD PMID:25821032 NCBI chr11:91,317,354...91,340,148
Ensembl chr11:91,317,355...91,340,148
JBrowse link
G Ldlr low density lipoprotein receptor increases expression
multiple interactions
ISO olanzapine results in increased expression of LDLR mRNA
olanzapine promotes the reaction [SREBF1 protein results in increased expression of LDLR mRNA]
CTD PMID:17052361 PMID:17651982 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675
JBrowse link
G Lep leptin increases expression
multiple interactions
ISO olanzapine results in increased expression of LEP protein
Olanzapine results in increased expression of LEP protein
capsazepine inhibits the reaction [Olanzapine results in increased expression of LEP protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of LEP protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of LEP protein]
CTD PMID:11927762 PMID:19512971 PMID:32652086 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
JBrowse link
G Mal mal, T-cell differentiation protein decreases expression ISO olanzapine results in decreased expression of MAL mRNA CTD PMID:18797397 NCBI chr 3:135,317,664...135,341,423
Ensembl chr 3:135,317,664...135,341,423
JBrowse link
G Maoa monoamine oxidase A increases expression EXP olanzapine results in increased expression of MAOA mRNA CTD PMID:15964593 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:8,615,239...8,682,631
JBrowse link
G Maob monoamine oxidase B increases expression EXP olanzapine results in increased expression of MAOB mRNA CTD PMID:15964593 NCBI chr  X:8,490,405...8,594,065
Ensembl chr  X:8,490,344...8,594,375
JBrowse link
G Map2 microtubule-associated protein 2 increases expression EXP olanzapine results in increased expression of MAP2 mRNA CTD PMID:15079866 NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP Olanzapine results in increased expression of MKI67 protein CTD PMID:38437955 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593
JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR gene polymorphism affects the susceptibility to olanzapine; MTHFR protein affects the susceptibility to olanzapine CTD PMID:20547447 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105
JBrowse link
G Ncan neurocan decreases expression ISO olanzapine results in decreased expression of NCAN mRNA CTD PMID:18797397 NCBI chr16:19,335,907...19,362,371
Ensembl chr16:19,335,907...19,362,371
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase decreases expression ISO olanzapine results in decreased expression of NEDD4 mRNA; olanzapine results in decreased expression of NEDD4 protein CTD PMID:18797397 NCBI chr 8:82,264,751...82,349,642
Ensembl chr 8:82,264,649...82,349,633
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression ISO Olanzapine results in decreased expression of NFE2L2 protein CTD PMID:37019375 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression
ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of NFKB1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NFKB1 mRNA] CTD PMID:32652086 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
JBrowse link
G Nptn neuroplastin increases expression ISO olanzapine results in increased expression of NPTN mRNA CTD PMID:18797397 NCBI chr 8:67,892,678...67,959,231
Ensembl chr 8:67,892,702...67,959,236
JBrowse link
G Npy neuropeptide Y decreases expression
increases expression
multiple interactions
EXP
ISO
olanzapine results in decreased expression of NPY mRNA
Olanzapine results in increased expression of NPY mRNA
capsazepine inhibits the reaction [Olanzapine results in increased expression of NPY mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of NPY mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NPY mRNA]
olanzapine results in increased expression of NPY protein
CTD PMID:16516965 PMID:21695181 PMID:32652086 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310
JBrowse link
G Numbl NUMB-like, endocytic adaptor protein decreases expression ISO olanzapine results in decreased expression of NUMBL mRNA CTD PMID:18797397 NCBI chr 1:91,677,437...91,701,415
Ensembl chr 1:91,677,242...91,701,424
JBrowse link
G Pde1a phosphodiesterase 1A increases expression EXP olanzapine results in increased expression of PDE1A mRNA CTD PMID:20222156 NCBI chr 3:85,152,053...85,432,289
Ensembl chr 3:85,154,184...85,519,212
JBrowse link
G Pde8b phosphodiesterase 8B increases expression EXP olanzapine results in increased expression of PDE8B mRNA CTD PMID:20222156 NCBI chr 2:28,009,841...28,244,050
Ensembl chr 2:28,011,359...28,244,327
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions
decreases expression
ISO capsazepine inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA] CTD PMID:32652086 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347
JBrowse link
G Plac8 placenta associated 8 affects phosphorylation ISO olanzapine affects the phosphorylation of C15 protein CTD PMID:25821032 NCBI chr14:9,356,950...9,378,586
Ensembl chr14:9,356,972...9,378,572
JBrowse link
G Plp1 proteolipid protein 1 decreases expression ISO olanzapine results in decreased expression of PLP1 mRNA CTD PMID:18797397 NCBI chr  X:104,933,921...104,993,317
Ensembl chr  X:104,975,780...104,993,314
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 affects expression EXP olanzapine affects the expression of PNPLA2 mRNA CTD PMID:23226405 NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:205,982,258...205,987,359
JBrowse link
G Pomc proopiomelanocortin decreases expression
multiple interactions
EXP
ISO
olanzapine results in decreased expression of POMC protein
Olanzapine results in decreased expression of POMC mRNA
capsazepine inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA]
CTD PMID:21695181 PMID:32652086 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO olanzapine results in increased expression of PPARG protein alternative form CTD PMID:17651982 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions
EXP olanzapine results in decreased expression of PPARGC1A mRNA
[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of PPARGC1A mRNA; olanzapine promotes the reaction [1-(carboxymethylthio)tetradecane results in decreased expression of PPARGC1A mRNA]
CTD PMID:23226405 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 increases expression
multiple interactions
ISO Olanzapine results in increased expression of PRKAG2 mRNA
capsazepine inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA]
CTD PMID:32652086 NCBI chr 4:10,744,695...10,985,939
Ensembl chr 4:10,744,588...10,985,939
JBrowse link
G Prl prolactin multiple interactions
increases expression
increases secretion
ISO
EXP
[olanzapine co-treated with Fluoxetine] results in increased expression of PRL protein
Olanzapine results in increased expression of PRL protein
Bromocriptine inhibits the reaction [Olanzapine results in increased expression of PRL protein]
olanzapine results in increased secretion of PRL protein
olanzapine results in increased expression of PRL protein
CTD PMID:9090331 PMID:9265911 PMID:9376336 PMID:10831029 PMID:11048906 More... NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217
JBrowse link
G Prlr prolactin receptor increases expression EXP Olanzapine results in increased expression of PRLR mRNA; Olanzapine results in increased expression of PRLR protein CTD PMID:38437955 NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882
JBrowse link
G Prrc2a proline-rich coiled-coil 2A decreases expression ISO olanzapine results in decreased expression of PRRC2A mRNA CTD PMID:18797397 NCBI chr20:3,660,981...3,686,715
Ensembl chr20:3,663,400...3,678,778
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO olanzapine results in decreased expression of RAPGEF4 mRNA CTD PMID:18797397 NCBI chr 3:77,217,024...77,509,933
Ensembl chr 3:77,217,039...77,509,978
JBrowse link
G Reln reelin increases expression EXP olanzapine results in increased expression of RELN mRNA; olanzapine results in increased expression of RELN protein CTD PMID:19359144 NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162
JBrowse link
G Rgs7 regulator of G-protein signaling 7 multiple interactions
increases expression
EXP [[Olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [Olanzapine results in increased expression of RGS7 mRNA]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [Olanzapine results in increased expression of RGS7 protein]; Olanzapine promotes the reaction [[STAT3 protein binds to RGS7 promoter] which results in increased expression of RGS7 mRNA]; Olanzapine promotes the reaction [STAT3 protein binds to RGS7 promoter]
olanzapine results in increased expression of RGS7 mRNA; olanzapine results in increased expression of RGS7 protein
CTD PMID:18976543 PMID:19304867 NCBI chr13:89,511,492...89,941,082
Ensembl chr13:89,511,150...89,940,987
JBrowse link
G Rtn4 reticulon 4 decreases expression ISO olanzapine results in decreased expression of RTN4 mRNA CTD PMID:18797397 NCBI chr14:107,651,001...107,698,610
Ensembl chr14:107,650,732...107,698,611
JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression ISO olanzapine results in decreased expression of S100A9 mRNA CTD PMID:18797397 NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO olanzapine results in increased expression of SC5D mRNA CTD PMID:17052361 NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277
JBrowse link
G Serpina3n serpin family A member 3N increases phosphorylation ISO Olanzapine results in increased phosphorylation of SERPINA3 protein CTD PMID:25821032 NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415
JBrowse link
G Serping1 serpin family G member 1 affects phosphorylation ISO olanzapine affects the phosphorylation of SERPING1 protein CTD PMID:25821032 NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:90,249,423...90,258,717
JBrowse link
G Serpini1 serpin family I member 1 decreases expression ISO olanzapine results in decreased expression of SERPINI1 mRNA CTD PMID:18797397 NCBI chr 2:162,645,209...162,731,737
Ensembl chr 2:162,645,350...162,731,740
JBrowse link
G Shbg sex hormone binding globulin decreases expression ISO olanzapine results in decreased expression of SHBG protein CTD PMID:19512971 NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO olanzapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
JBrowse link
G Slc22a5 solute carrier family 22 member 5 decreases expression
multiple interactions
ISO Olanzapine results in decreased expression of SLC22A5 mRNA; Olanzapine results in decreased expression of SLC22A5 protein
Olanzapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine analog]
CTD PMID:31437515 NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077
JBrowse link
G Slc27a2 solute carrier family 27 member 2 increases expression ISO Olanzapine results in increased expression of SLC27A2 mRNA CTD PMID:31437515 NCBI chr 3:134,258,101...134,295,581
Ensembl chr 3:134,258,101...134,295,581
JBrowse link
G Slc27a5 solute carrier family 27 member 5 increases expression ISO Olanzapine results in increased expression of SLC27A5 mRNA CTD PMID:31437515 NCBI chr 1:82,688,742...82,699,335
Ensembl chr 1:82,688,750...82,699,358
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO olanzapine results in increased expression of SLC2A4 mRNA CTD PMID:16002093 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Olanzapine results in decreased expression of SLC7A11 mRNA CTD PMID:37005277 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695
JBrowse link
G Snap25 synaptosome associated protein 25 affects response to substance ISO SNAP25 gene SNP affects the susceptibility to olanzapine CTD PMID:15823421 NCBI chr 3:144,494,579...144,576,449
Ensembl chr 3:144,494,595...144,576,448
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases activity
increases expression
EXP
ISO
olanzapine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; olanzapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]; olanzapine inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD1 mRNA]
Olanzapine results in decreased activity of SOD1 protein
Dietary Fats promotes the reaction [Olanzapine results in decreased activity of SOD1 protein]
olanzapine results in increased expression of SOD1 mRNA
CTD PMID:12752374 PMID:12868070 PMID:16564057 PMID:37019375 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression
ISO olanzapine promotes the reaction [SREBF1 protein results in increased expression of LDLR mRNA]; olanzapine results in increased activity of and results in increased expression of SREBF1 protein
olanzapine results in increased expression of SREBF1 mRNA
CTD PMID:17651982 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO
EXP
olanzapine results in increased cleavage of and results in increased activity of SREBF2 protein
[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of SREBF2 mRNA
CTD PMID:17052361 PMID:23226405 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP olanzapine promotes the reaction [[STAT3 protein binds to RGS7 promoter] which results in increased expression of RGS7 mRNA]; olanzapine promotes the reaction [STAT3 protein binds to RGS7 promoter] CTD PMID:18976543 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
JBrowse link
G Sypl1 synaptophysin-like 1 decreases expression ISO Olanzapine results in decreased expression of SYPL1 mRNA CTD PMID:18797397 NCBI chr 6:55,292,555...55,311,519
Ensembl chr 6:55,292,567...55,314,714
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP olanzapine inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:15276877 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of TNF protein]; Dietary Fats promotes the reaction [Olanzapine results in increased expression of TNF protein]; Lithium inhibits the reaction [Olanzapine results in increased expression of TNF mRNA]; Lithium inhibits the reaction [Olanzapine results in increased expression of TNF protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of TNF protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TNF protein]
Olanzapine results in increased expression of TNF mRNA; Olanzapine results in increased expression of TNF protein
CTD PMID:30695037 PMID:32652086 PMID:37019375 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tp53 tumor protein p53 increases expression ISO olanzapine results in increased expression of TP53 mRNA CTD PMID:16160616 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases expression
ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of TRPV1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV1 mRNA] CTD PMID:32652086 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 multiple interactions
increases expression
ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV3 mRNA] CTD PMID:32652086 NCBI chr10:58,382,054...58,413,657
Ensembl chr10:58,382,054...58,411,800
JBrowse link
G Ttr transthyretin increases expression EXP olanzapine results in increased expression of TTR mRNA CTD PMID:15927202 NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions EXP [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of UCP1 mRNA CTD PMID:23226405 NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420
JBrowse link
G Vipr2 vasoactive intestinal peptide receptor 2 affects expression ISO olanzapine affects the expression of VIPR2 mRNA CTD PMID:27900577 NCBI chr 6:143,139,672...143,213,609
Ensembl chr 6:143,144,523...143,213,609
JBrowse link
G Vldlr very low density lipoprotein receptor increases expression EXP olanzapine results in increased expression of VLDLR protein CTD PMID:19359144 NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:234,240,121...234,272,154
JBrowse link
perazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases methylation ISO CYP3A4 protein results in decreased methylation of Perazine CTD PMID:11026737 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases oxidation ISO FMO3 protein results in increased oxidation of Perazine CTD PMID:11026737 NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256
JBrowse link
ponatinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions
decreases phosphorylation
decreases activity
ISO ponatinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of ABL1 protein mutant form]; ponatinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of CRKL protein]; ponatinib inhibits the reaction [ABL1 protein results in increased phosphorylation of ABL1 protein]
ponatinib results in decreased phosphorylation of ABL1 protein; ponatinib results in decreased phosphorylation of ABL1 protein mutant form
ponatinib analog results in decreased activity of ABL1 protein; ponatinib analog results in decreased activity of ABL1 protein mutant form; ponatinib results in decreased activity of ABL1 protein; ponatinib results in decreased activity of ABL1 protein mutant form
CTD PMID:19878872 PMID:20513156 PMID:21561767 PMID:22781593 PMID:25304212 NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:35,377,391...35,480,846
JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase decreases activity ISO ponatinib results in decreased activity of ABL2 protein CTD PMID:19878872 NCBI chr13:71,223,902...71,319,770
Ensembl chr13:71,224,019...71,389,775
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased phosphorylation of AKT1 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of AKT1 protein] CTD PMID:25053825 PMID:25304212 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO ponatinib results in increased expression of BAX mRNA
[gossypol acetic acid results in increased abundance of Gossypol] promotes the reaction [ponatinib results in increased expression of BAX mRNA]
CTD PMID:34699866 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of BCL2 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of BCL2 protein]
[gossypol acetic acid results in increased abundance of Gossypol] promotes the reaction [ponatinib results in decreased expression of BCL2 mRNA]; ponatinib promotes the reaction [[gossypol acetic acid results in increased abundance of Gossypol] which results in decreased expression of BCL2 mRNA]
CTD PMID:25053825 PMID:34699866 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions
increases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in increased expression of BCL2L11 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in increased expression of BCL2L11 protein] CTD PMID:25053825 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695
JBrowse link
G Bcr BCR activator of RhoGEF and GTPase decreases phosphorylation ISO ponatinib results in decreased phosphorylation of BCR protein mutant form CTD PMID:19878872 NCBI chr20:13,468,732...13,596,333
Ensembl chr20:13,468,732...13,596,333
JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of BLK protein CTD PMID:19878872 NCBI chr15:41,802,701...41,841,004
Ensembl chr15:41,802,994...41,840,982
JBrowse link
G Bmx BMX non-receptor tyrosine kinase decreases activity ISO ponatinib results in decreased activity of BMX protein CTD PMID:19878872 NCBI chr  X:33,859,128...33,921,876
Ensembl chr  X:33,859,129...33,921,874
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases activity ISO ponatinib analog results in decreased activity of BRAF protein; ponatinib analog results in decreased activity of BRAF protein mutant form CTD PMID:21561767 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931
JBrowse link
G Casp1 caspase 1 increases expression
multiple interactions
ISO ponatinib results in increased expression of CASP1 mRNA
Acetylcysteine inhibits the reaction [ponatinib results in increased activity of CASP1 protein]; Acetylcysteine inhibits the reaction [ponatinib results in increased expression of CASP1 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ponatinib results in increased activity of and results in increased cleavage of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ponatinib results in increased expression of CASP1 mRNA]; ponatinib results in increased activity of and results in increased cleavage of CASP1 protein
CTD PMID:39134127 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
JBrowse link
G Casp3 caspase 3 increases cleavage ISO ponatinib results in increased cleavage of CASP3 protein CTD PMID:29341879 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
ISO [gossypol acetic acid results in increased abundance of Gossypol] promotes the reaction [ponatinib results in increased expression of CASP9 protein]; ponatinib promotes the reaction [[gossypol acetic acid results in increased abundance of Gossypol] which results in increased expression of CASP9 protein] CTD PMID:34699866 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions
increases activity
ISO [gossypol acetic acid results in increased abundance of Gossypol] promotes the reaction [ponatinib results in increased activity of CAT protein]; ponatinib promotes the reaction [[gossypol acetic acid results in increased abundance of Gossypol] which results in increased activity of CAT protein] CTD PMID:34699866 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of CDK4 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK4 protein] CTD PMID:25053825 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of CDK6 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK6 protein] CTD PMID:25053825 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in increased expression of CDKN1A protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in increased expression of CDKN1A protein] CTD PMID:25053825 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein multiple interactions
decreases phosphorylation
ISO ponatinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of CRKL protein]
ponatinib results in decreased phosphorylation of CRKL protein
CTD PMID:19878872 PMID:25304212 NCBI chr11:97,033,033...97,067,457
Ensembl chr11:97,024,782...97,067,457
JBrowse link
G Csf1r colony stimulating factor 1 receptor decreases activity ISO ponatinib analog results in decreased activity of CSF1R protein; ponatinib results in decreased activity of CSF1R protein CTD PMID:19878872 PMID:21561767 NCBI chr18:56,834,152...56,860,804
Ensembl chr18:56,817,049...56,860,806
JBrowse link
G Csk C-terminal Src kinase decreases activity ISO ponatinib results in decreased activity of CSK protein CTD PMID:19878872 NCBI chr 8:66,925,650...66,944,861
Ensembl chr 8:66,925,651...66,930,274
JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 decreases phosphorylation ISO ponatinib inhibits the reaction [collagen increases autophosphorylation of DDR1 in U2OS cells] RGD PMID:24768818 RGD:151347549 NCBI chr20:3,047,269...3,069,277
Ensembl chr20:3,050,375...3,069,276
JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 decreases activity ISO ponatinib results in decreased activity of DDR2 protein CTD PMID:19878872 NCBI chr13:84,726,412...84,851,032
Ensembl chr13:84,731,180...84,850,288
JBrowse link
G Egfr epidermal growth factor receptor decreases activity ISO ponatinib results in decreased activity of EGFR protein mutant form CTD PMID:19878872 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358
JBrowse link
G Epha1 Eph receptor A1 decreases activity ISO ponatinib results in decreased activity of EPHA1 protein CTD PMID:19878872 NCBI chr 4:72,213,022...72,227,543
Ensembl chr 4:72,213,037...72,227,474
JBrowse link
G Epha2 Eph receptor A2 decreases activity ISO ponatinib analog results in decreased activity of EPHA2 protein; ponatinib results in decreased activity of EPHA2 protein CTD PMID:19878872 PMID:21561767 NCBI chr 5:158,888,629...158,917,100
Ensembl chr 5:158,888,629...158,917,234
JBrowse link
G Epha3 Eph receptor A3 decreases activity ISO ponatinib analog results in decreased activity of EPHA3 protein; ponatinib results in decreased activity of EPHA3 protein CTD PMID:19878872 PMID:21561767 NCBI chr11:14,585,041...14,920,721
Ensembl chr11:14,586,727...14,920,425
JBrowse link
G Epha4 Eph receptor A4 decreases activity ISO ponatinib results in decreased activity of EPHA4 protein CTD PMID:19878872 NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:86,263,982...86,406,755
JBrowse link
G Epha5 EPH receptor A5 decreases activity ISO ponatinib results in decreased activity of EPHA5 protein CTD PMID:19878872 NCBI chr14:24,007,400...24,374,854
Ensembl chr14:24,008,122...24,374,848
JBrowse link
G Epha7 Eph receptor A7 decreases activity ISO ponatinib analog results in decreased activity of EPHA7 protein; ponatinib results in decreased activity of EPHA7 protein CTD PMID:19878872 PMID:21561767 NCBI chr 5:47,771,776...47,925,189
Ensembl chr 5:47,771,865...47,925,058
JBrowse link
G Epha8 Eph receptor A8 decreases activity ISO ponatinib results in decreased activity of EPHA8 protein CTD PMID:19878872 NCBI chr 5:154,449,566...154,476,966
Ensembl chr 5:154,449,566...154,476,966
JBrowse link
G Ephb1 Eph receptor B1 decreases activity ISO ponatinib results in decreased activity of EPHB1 protein CTD PMID:19878872 NCBI chr 8:111,386,432...111,823,759
Ensembl chr 8:111,386,432...111,823,759
JBrowse link
G Ephb2 Eph receptor B2 decreases activity ISO ponatinib results in decreased activity of EPHB2 protein CTD PMID:19878872 NCBI chr 5:154,179,065...154,360,459
Ensembl chr 5:154,179,065...154,360,615
JBrowse link
G Ephb3 Eph receptor B3 decreases activity ISO ponatinib results in decreased activity of EPHB3 protein CTD PMID:19878872 NCBI chr11:93,345,098...93,363,775
Ensembl chr11:93,345,098...93,363,775
JBrowse link
G Ephb4 EPH receptor B4 decreases activity ISO ponatinib results in decreased activity of EPHB4 protein CTD PMID:19878872 NCBI chr12:24,963,174...24,988,473
Ensembl chr12:24,963,174...24,988,388
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases activity ISO ponatinib results in decreased activity of ERBB4 protein CTD PMID:19878872 NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:76,973,227...78,045,772
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases activity
decreases phosphorylation
ISO ponatinib analog results in decreased activity of FGFR1 protein; ponatinib results in decreased activity of FGFR1 protein; ponatinib results in decreased activity of FGFR1 protein mutant form
ponatinib results in decreased phosphorylation of FGFR1 protein mutant form
CTD PMID:19878872 PMID:21482694 PMID:21561767 PMID:22875613 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:73,194,631...73,249,855
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases activity ISO ponatinib analog results in decreased activity of FGFR2 protein; ponatinib results in decreased activity of FGFR2 protein; ponatinib results in decreased activity of FGFR2 protein mutant form CTD PMID:19878872 PMID:21561767 NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:194,175,705...194,280,914
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases activity ISO ponatinib analog results in decreased activity of FGFR3 protein; ponatinib results in decreased activity of FGFR3 protein CTD PMID:19878872 PMID:21561767 NCBI chr14:81,211,800...81,227,215
Ensembl chr14:81,211,800...81,227,209
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 decreases activity
decreases expression
multiple interactions
ISO ponatinib analog results in decreased activity of FGFR4 protein; ponatinib results in decreased activity of FGFR4 protein
ponatinib results in decreased expression of FGFR4 mRNA
[gossypol acetic acid results in increased abundance of Gossypol] promotes the reaction [ponatinib results in decreased expression of FGFR4 mRNA]; ponatinib promotes the reaction [[gossypol acetic acid results in increased abundance of Gossypol] which results in decreased expression of FGFR4 mRNA]
CTD PMID:19878872 PMID:21561767 PMID:34699866 NCBI chr17:9,466,686...9,481,423
Ensembl chr17:9,466,692...9,481,389
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of FGR protein CTD PMID:19878872 NCBI chr 5:150,473,767...150,503,524
Ensembl chr 5:150,473,792...150,503,169
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases activity ISO ponatinib analog results in decreased activity of FLT1 protein; ponatinib results in decreased activity of FLT1 protein CTD PMID:19878872 PMID:21561767 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases activity
decreases phosphorylation
multiple interactions
ISO ponatinib analog results in decreased activity of FLT3 protein; ponatinib results in decreased activity of FLT3 protein; ponatinib results in decreased activity of FLT3 protein mutant form
ponatinib results in decreased phosphorylation of FLT3 protein mutant form
ponatinib inhibits the reaction [FLT3 protein mutant form results in increased phosphorylation of FLT3 protein mutant form]
CTD PMID:19878872 PMID:21482694 PMID:21561767 PMID:22409268 NCBI chr12:12,660,035...12,735,584
Ensembl chr12:12,659,946...12,735,581
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 decreases activity ISO ponatinib analog results in decreased activity of FLT4 protein; ponatinib results in decreased activity of FLT4 protein CTD PMID:19878872 PMID:21561767 NCBI chr10:34,414,834...34,455,878
Ensembl chr10:34,414,733...34,456,645
JBrowse link
G Frk fyn-related Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of FRK protein CTD PMID:19878872 NCBI chr20:39,820,441...39,926,065
Ensembl chr20:39,820,295...39,926,362
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of FYN protein CTD PMID:19878872 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:44,322,361...44,515,479
JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO ponatinib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Gsdmd gasdermin D multiple interactions
increases expression
ISO N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ponatinib results in increased expression of GSDMD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ponatinib results in increased expression of GSDMD protein]
ponatinib results in increased expression of GSDMD mRNA; ponatinib results in increased expression of GSDMD protein
CTD PMID:39134127 NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:109,422,910...109,430,722
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of HCK protein CTD PMID:19878872 NCBI chr 3:162,031,833...162,074,933
Ensembl chr 3:162,031,817...162,074,935
JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions
ISO ponatinib results in increased secretion of IL1B protein
Acetylcysteine inhibits the reaction [ponatinib results in increased secretion of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ponatinib results in increased secretion of IL1B protein]
CTD PMID:39134127 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Jak1 Janus kinase 1 decreases activity ISO ponatinib results in decreased activity of JAK1 protein CTD PMID:19878872 NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758
JBrowse link
G Jak2 Janus kinase 2 decreases activity ISO ponatinib results in decreased activity of JAK2 protein CTD PMID:19878872 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762
JBrowse link
G Jak3 Janus kinase 3 decreases activity ISO ponatinib results in decreased activity of JAK3 protein CTD PMID:19878872 NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,420,415...18,433,222
JBrowse link
G Kdr kinase insert domain receptor decreases activity ISO ponatinib analog results in decreased activity of KDR protein; ponatinib results in decreased activity of KDR protein CTD PMID:19878872 PMID:21561767 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases activity
decreases phosphorylation
ISO ponatinib results in decreased activity of KIT protein; ponatinib results in decreased activity of KIT protein mutant form
ponatinib results in decreased phosphorylation of KIT protein mutant form
CTD PMID:19878872 PMID:21482694 NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,903,033...32,978,812
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of LCK protein CTD PMID:19878872 NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:147,172,642...147,201,267
JBrowse link
G Lmna lamin A/C increases cleavage ISO ponatinib results in increased cleavage of LMNA protein CTD PMID:22875613 NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:176,237,564...176,288,072
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of LYN protein CTD PMID:19878872 NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:21,437,084...21,554,461
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases lipidation ISO ponatinib results in increased lipidation of MAP1LC3A protein CTD PMID:29341879 NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:164,243,093...164,244,850
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased phosphorylation of MAPK1 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of MAPK1 protein] CTD PMID:22409268 PMID:22875613 PMID:25053825 PMID:25304212 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased phosphorylation of MAPK3 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of MAPK3 protein] CTD PMID:22409268 PMID:22875613 PMID:25053825 PMID:25304212 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO ponatinib results in decreased expression of MCL1 protein CTD PMID:22409268 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of MYC protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of MYC protein] CTD PMID:25053825 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression
multiple interactions
ISO ponatinib results in increased expression of NLRP3 mRNA; ponatinib results in increased expression of NLRP3 protein
N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ponatinib results in increased expression of NLRP3 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ponatinib results in increased expression of NLRP3 protein]
CTD PMID:39134127 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 decreases activity ISO ponatinib results in decreased activity of NTRK1 protein CTD PMID:19878872 NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:175,534,844...175,551,787
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 decreases activity ISO ponatinib results in decreased activity of NTRK2 protein CTD PMID:19878872 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 decreases activity ISO ponatinib results in decreased activity of NTRK3 protein CTD PMID:19878872 NCBI chr 1:141,526,192...141,913,575
Ensembl chr 1:141,542,569...141,913,004
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in increased cleavage of PARP1 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in increased cleavage of PARP1 protein] CTD PMID:21482694 PMID:22875613 PMID:25053825 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha decreases activity
decreases phosphorylation
ISO ponatinib analog results in decreased activity of PDGFRA protein; ponatinib results in decreased activity of PDGFRA protein; ponatinib results in decreased activity of PDGFRA protein mutant form
ponatinib results in decreased phosphorylation of PDGFRA protein mutant form
CTD PMID:19878872 PMID:21482694 PMID:21561767 NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,360,028...33,408,516
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases activity ISO ponatinib analog results in decreased activity of PDGFRB protein; ponatinib results in decreased activity of PDGFRB protein CTD PMID:19878872 PMID:21561767 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta decreases activity ISO ponatinib results in decreased activity of PTK2B protein CTD PMID:19878872 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:44,531,249...44,656,806
JBrowse link
G Ptk6 protein tyrosine kinase 6 decreases activity ISO ponatinib results in decreased activity of PTK6 protein CTD PMID:19878872 NCBI chr 3:188,684,633...188,693,224
Ensembl chr 3:188,684,633...188,693,224
JBrowse link
G Ret ret proto-oncogene decreases activity ISO ponatinib analog results in decreased activity of RET protein; ponatinib results in decreased activity of RET protein; ponatinib results in decreased activity of RET protein mutant form CTD PMID:19878872 PMID:21561767 NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:152,998,812...153,040,556
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases activity ISO ponatinib analog results in decreased activity of SRC protein; ponatinib results in decreased activity of SRC protein CTD PMID:19878872 PMID:21561767 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions
decreases phosphorylation
ISO ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5A protein]
ponatinib results in decreased phosphorylation of STAT5A protein
CTD PMID:22875613 PMID:25053825 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:86,285,547...86,310,184
JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions ISO ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5B protein] CTD PMID:25053825 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990
JBrowse link
G Tek TEK receptor tyrosine kinase decreases activity ISO ponatinib analog results in decreased activity of TEK protein; ponatinib results in decreased activity of TEK protein CTD PMID:19878872 PMID:21561767 NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:114,723,006...114,849,991
JBrowse link
G Tnni3 troponin I3, cardiac type increases secretion ISO ponatinib results in increased secretion of TNNI3 protein CTD PMID:25304212 NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO [gossypol acetic acid results in increased abundance of Gossypol] promotes the reaction [ponatinib results in increased expression of TRP53 protein]; ponatinib promotes the reaction [[gossypol acetic acid results in increased abundance of Gossypol] which results in increased expression of TRP53 protein] CTD PMID:34699866 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Tyk2 tyrosine kinase 2 decreases activity ISO ponatinib results in decreased activity of TYK2 protein CTD PMID:19878872 NCBI chr 8:27,918,054...27,943,319
Ensembl chr 8:27,916,496...27,943,278
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity ISO ponatinib results in decreased activity of UGT1A1 protein CTD PMID:37597759 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 decreases activity ISO ponatinib results in decreased activity of UGT1A9 protein CTD PMID:37597759 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO [gossypol acetic acid results in increased abundance of Gossypol] promotes the reaction [ponatinib results in decreased expression of VEGFA protein]; ponatinib promotes the reaction [[gossypol acetic acid results in increased abundance of Gossypol] which results in decreased expression of VEGFA protein] CTD PMID:34699866 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of YES1 protein CTD PMID:19878872 NCBI chr 9:120,646,657...120,753,880
Ensembl chr 9:120,646,838...120,746,441
JBrowse link
prochlorperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases activity ISO Prochlorperazine results in increased activity of ACHE protein CTD PMID:29614332 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Prochlorperazine binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
JBrowse link
G Tfeb transcription factor EB affects localization ISO Prochlorperazine affects the localization of TFEB protein CTD PMID:28366621 NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:20,696,441...20,727,863
JBrowse link
rifampicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadac arylacetamide deacetylase multiple interactions
increases hydrolysis
decreases acetylation
ISO AADAC mRNA affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; bis(4-nitrophenyl)phosphate inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Isoflurophate inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Phenylmethylsulfonyl Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Sodium Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]
AADAC protein results in increased hydrolysis of Rifampin
CTD PMID:21856291 PMID:22207054 NCBI chr 2:146,293,449...146,351,061
Ensembl chr 2:146,313,279...146,324,525
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 decreases expression
increases expression
ISO Rifampin results in decreased expression of ABCA1 mRNA; Rifampin results in decreased expression of ABCA1 protein
Rifampin results in increased expression of ABCA1 mRNA; Rifampin results in increased expression of ABCA1 protein
CTD PMID:15883047 PMID:17088262 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473
JBrowse link
G Abca2 ATP binding cassette subfamily A member 2 increases expression ISO Rifampin results in increased expression of ABCA2 mRNA CTD PMID:27199754 NCBI chr 3:28,642,660...28,662,689
Ensembl chr 3:28,642,758...28,662,681
JBrowse link
G Abca8 ATP binding cassette subfamily A member 8 decreases expression ISO Rifampin results in decreased expression of ABCA8 mRNA CTD PMID:27199754 NCBI chr10:95,416,984...95,490,647
Ensembl chr10:95,416,205...95,490,452
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
multiple interactions
decreases activity
ISO
EXP
Rifampin results in decreased expression of ABCB11 mRNA
[Rifampin co-treated with Isoniazid] results in decreased expression of ABCB11 protein
Rifampin results in decreased expression of ABCB11 protein
tanshinone inhibits the reaction [Rifampin results in decreased expression of ABCB11 mRNA]; tanshinone inhibits the reaction [Rifampin results in decreased expression of ABCB11 protein]
Rifampin results in decreased activity of ABCB11 protein
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of ABCB11 protein; Rifampin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Rifampin results in decreased expression of ABCB11 mRNA; Rifampin results in decreased expression of ABCB11 protein
CTD PMID:12135489 PMID:16837569 PMID:20829430 PMID:24014644 PMID:25886055 More... NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
decreases activity
affects activity
ISO
EXP
[NR1I2 protein results in increased susceptibility to Rifampin] which results in increased expression of ABCB1 mRNA; [NR1I2 protein results in increased susceptibility to Rifampin] which results in increased expression of ABCB1 protein; [Rifampin binds to and results in increased activity of NR1I2 protein] promotes the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 protein; Camptothecin inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 protein]; mulberroside A inhibits the reaction [[NR1I2 protein results in increased susceptibility to Rifampin] which results in increased expression of ABCB1 mRNA]; mulberroside A inhibits the reaction [[NR1I2 protein results in increased susceptibility to Rifampin] which results in increased expression of ABCB1 protein]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]; pimecrolimus inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; Resveratrol inhibits the reaction [Rifampin results in increased expression of ABCB1 protein]; Rifampin promotes the reaction [ABCB1 protein results in increased transport of Digoxin]; Rifampin promotes the reaction [NR1I2 protein binds to ABCB1 promoter]
Rifampin results in increased expression of ABCB1 mRNA; Rifampin results in increased expression of ABCB1 protein
[Rifampin metabolite results in decreased activity of ABCB1A protein] which results in decreased abundance of Adenosine Triphosphate
Rifampin affects the activity of ABCB1 protein
CTD PMID:8632764 PMID:11744607 PMID:14722322 PMID:15276086 PMID:15290871 More... NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO Rifampin results in increased expression of ABCB4 mRNA CTD PMID:27199754 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 increases expression ISO Rifampin results in increased expression of ABCB6 mRNA CTD PMID:27199754 NCBI chr 9:84,117,222...84,125,939
Ensembl chr 9:84,117,220...84,125,526
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Rifampin results in increased expression of ABCC1 mRNA CTD PMID:17191263 PMID:35972551 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404
JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 increases expression ISO Rifampin results in increased expression of ABCC10 mRNA CTD PMID:27199754 NCBI chr 9:22,154,811...22,174,743
Ensembl chr 9:22,154,804...22,174,743
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
multiple interactions
increases expression
ISO
EXP
ABCC2 protein affects the export of Rifampin
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of ABCC2 protein
Rifampin results in increased expression of ABCC2; Rifampin results in increased expression of ABCC2 mRNA; Rifampin results in increased expression of ABCC2 protein
[Rifampin co-treated with ABCC2 gene mutant form] results in increased expression of ABCC3 protein
CTD PMID:11836020 PMID:12206135 PMID:15652233 PMID:16837569 PMID:16952291 More... NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression
increases activity
ISO [Rifampin co-treated with ABCC2 gene mutant form] results in increased expression of ABCC3 protein; [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; Rifampin inhibits the reaction [Decitabine results in increased expression of ABCC3 mRNA]
Rifampin results in increased expression of ABCC3 mRNA
Rifampin results in increased activity of ABCC3 protein
CTD PMID:14570758 PMID:16837569 PMID:16952291 PMID:19041851 PMID:20832446 More... NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 increases expression ISO Rifampin results in increased expression of ABCC5 mRNA CTD PMID:19041851 NCBI chr11:93,975,579...94,071,659
Ensembl chr11:93,978,274...94,071,655
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 increases expression ISO Rifampin results in increased expression of ABCC6 mRNA CTD PMID:27199754 NCBI chr 1:105,583,681...105,637,895
Ensembl chr 1:105,583,682...105,637,895
JBrowse link
G Abcf1 ATP binding cassette subfamily F member 1 increases expression ISO Rifampin results in increased expression of ABCF1 mRNA CTD PMID:27199754 NCBI chr20:2,807,315...2,820,240
Ensembl chr20:2,807,106...2,820,240
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO Rifampin results in increased expression of ABCG1 mRNA; Rifampin results in increased expression of ABCG1 protein CTD PMID:12040753 PMID:17088262 NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression
multiple interactions
ISO Rifampin results in increased expression of ABCG2 mRNA; Rifampin results in increased expression of ABCG2 protein
Rifampin promotes the reaction [Dextran Sulfate results in decreased expression of ABCG2 mRNA]; Rifampin promotes the reaction [Lipopolysaccharides results in decreased expression of ABCG2 mRNA]
CTD PMID:16837569 PMID:27199754 PMID:35972551 PMID:38423481 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression ISO Rifampin results in increased expression of ABCG8 mRNA CTD PMID:27199754 NCBI chr 6:15,698,448...15,717,730
Ensembl chr 6:15,698,448...15,717,730
JBrowse link
G Abi3 ABI family, member 3 decreases expression ISO Rifampin results in decreased expression of ABI3 mRNA CTD PMID:24552687 NCBI chr10:81,266,571...81,277,561
Ensembl chr10:81,266,571...81,277,561
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression ISO Rifampin results in increased expression of ACACA mRNA CTD PMID:27806127 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888
JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Rifampin results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of ACSL4 protein CTD PMID:36878459 NCBI chr  X:110,739,633...110,803,416
Ensembl chr  X:110,739,648...110,803,261
JBrowse link
G Actr10 actin related protein 10 increases expression ISO Rifampin results in increased expression of ACTR10 mRNA CTD PMID:24552687 NCBI chr 6:95,182,082...95,208,325
Ensembl chr 6:95,182,111...95,209,021
JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide increases expression ISO Rifampin results in increased expression of ADH1C mRNA CTD PMID:12040753 NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:229,470,703...229,482,291
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [Rifampin affects the susceptibility to Dietary Fats] which results in decreased expression of ADIPOQ mRNA CTD PMID:33412187 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Rifampin results in decreased expression of ADORA2A mRNA CTD PMID:24552687 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802
JBrowse link
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 decreases expression ISO Rifampin results in decreased expression of AGAP2 mRNA CTD PMID:24552687 NCBI chr 7:64,782,618...64,799,624
Ensembl chr 7:64,782,612...64,799,640
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression
ISO [Rifampin co-treated with Benzo(a)pyrene] results in increased expression of AHR mRNA; [Rifampin co-treated with Monocrotophos] results in decreased expression of AHR mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of AHR protein; NR1I2 protein inhibits the reaction [[Rifampin co-treated with Benzo(a)pyrene] results in increased expression of AHR mRNA]
Rifampin results in increased expression of AHR mRNA; Rifampin results in increased expression of AHR protein
CTD PMID:22733800 PMID:28428138 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression
multiple interactions
ISO Rifampin results in increased expression of AKR1B10 mRNA
pazopanib inhibits the reaction [Rifampin results in increased expression of AKR1B10 mRNA]; pimecrolimus inhibits the reaction [Rifampin results in increased expression of AKR1B10 mRNA]
CTD PMID:29356861 NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 increases expression ISO Rifampin results in increased expression of ALAS1 mRNA CTD PMID:24259679 PMID:24552687 NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases activity
multiple interactions
ISO Rifampin results in increased activity of ALPL protein
[Rifampin co-treated with Isoniazid] results in increased activity of ALPL protein
CTD PMID:25886055 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167
JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO Rifampin results in decreased expression of ANGPTL3 mRNA CTD PMID:32535746 NCBI chr 5:118,818,494...118,825,531
Ensembl chr 5:118,818,499...118,826,444
JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of ANGPTL4 mRNA CTD PMID:21127053 NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681
JBrowse link
G Ankrd40 ankyrin repeat domain 40 increases expression EXP Rifampin results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr10:79,778,966...79,792,212
Ensembl chr10:56,415,260...56,416,345
Ensembl chr10:56,415,260...56,416,345
JBrowse link
G Ankrd65 ankyrin repeat domain 65 decreases expression ISO Rifampin results in decreased expression of ANKRD65 mRNA CTD PMID:24552687 NCBI chr 5:171,680,597...171,682,854
Ensembl chr 5:171,680,597...171,683,431
JBrowse link
G Anks1b ankyrin repeat and sterile alpha motif domain containing 1B decreases expression ISO Rifampin results in decreased expression of ANKS1B mRNA CTD PMID:24552687 NCBI chr 7:26,200,649...27,366,552
Ensembl chr 7:26,201,240...27,364,943
JBrowse link
G Anxa5 annexin A5 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA CTD PMID:21224054 NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400
JBrowse link
G Apob apolipoprotein B decreases expression
multiple interactions
affects secretion
ISO Rifampin results in decreased expression of APOB mRNA
ursodoxicoltaurine inhibits the reaction [Rifampin results in decreased expression of APOB mRNA]
Rifampin affects the secretion of APOB protein
CTD PMID:32535746 NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814
JBrowse link
G Apoc3 apolipoprotein C3 decreases expression
decreases secretion
ISO Rifampin results in decreased expression of APOC3 mRNA
Rifampin results in decreased secretion of APOC3 protein
CTD PMID:32535746 NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:55,428,024...55,458,679
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of AQP3 mRNA CTD PMID:21127053 NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:61,035,166...61,040,685
JBrowse link
G Aqp4 aquaporin 4 decreases expression ISO Rifampin results in decreased expression of AQP4 mRNA CTD PMID:24552687 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098
JBrowse link
G Arsj arylsulfatase family, member J decreases expression ISO Rifampin results in decreased expression of ARSJ mRNA CTD PMID:24552687 NCBI chr 2:217,449,147...217,529,142
Ensembl chr 2:217,449,147...217,529,142
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions ISO [Rifampin co-treated with Cobicistat] results in increased expression of ATF3 mRNA CTD PMID:33629115 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
EXP
ISO
ATF4 mutant form inhibits the reaction [Rifampin results in increased expression of HSPA5 protein]
Rifampin results in increased expression of ATF4 mRNA; Rifampin results in increased expression of ATF4 protein
4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of ATF4 protein]
CTD PMID:24638036 PMID:27470132 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Rifampin results in increased expression of ATF6 mRNA CTD PMID:32535746 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
decreases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein
Rifampin results in decreased expression of ATM mRNA
CTD PMID:21224054 PMID:24552687 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629
JBrowse link
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 increases expression
multiple interactions
ISO Rifampin results in increased expression of ATP6V0A1 protein
[Rotenone co-treated with Rifampin] results in increased expression of ATP6V0A1 protein; Rifampin inhibits the reaction [Rotenone results in decreased expression of ATP6V0A1 mRNA]; Rotenone inhibits the reaction [Rifampin results in increased expression of ATP6V0A1 protein]
CTD PMID:31648047 NCBI chr10:86,436,089...86,490,185
Ensembl chr10:86,436,141...86,490,181
JBrowse link
G Atp6v0d1 ATPase H+ transporting V0 subunit D1 multiple interactions ISO ATP6V0D1 protein affects the reaction [Rifampin inhibits the reaction [Rotenone results in increased lipidation of MAP1LC3B protein]] CTD PMID:31648047 NCBI chr19:50,313,268...50,357,248
Ensembl chr19:50,313,273...50,357,395
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression ISO Rifampin results in increased expression of ATRX mRNA CTD PMID:24552687 NCBI chr  X:74,916,548...75,062,880
Ensembl chr  X:74,916,548...75,062,880
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
ISO [Isoniazid co-treated with Rifampin] results in increased expression of BAX protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA; [Rifampin co-treated with Cobicistat] results in increased expression of BAX mRNA; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased expression of BAX protein]
[Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein
Rifampin results in decreased expression of BAX protein
CTD PMID:11958592 PMID:12645856 PMID:21224054 PMID:21419764 PMID:31629065 More... NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
ISO Rifampin results in increased expression of BCL2 protein
[Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein
[Isoniazid co-treated with Rifampin] results in decreased expression of BCL2 protein; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in decreased expression of BCL2 protein]
CTD PMID:11958592 PMID:21419764 PMID:31629065 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
multiple interactions
ISO Rifampin results in increased expression of BCL2L1 protein
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA
CTD PMID:11958592 PMID:12645856 PMID:21224054 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of BHLHE40 mRNA CTD PMID:21127053 NCBI chr 4:143,174,450...143,180,150
Ensembl chr 4:143,174,048...143,180,783
JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of BMP4 mRNA CTD PMID:21127053 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:22,098,470...22,105,172
JBrowse link
G C17h9orf153 similar to human chromosome 9 open reading frame 153 decreases expression ISO Rifampin results in decreased expression of C9ORF153 mRNA CTD PMID:24552687 NCBI chr17:4,978,994...4,987,920
Ensembl chr17:4,981,452...4,987,918
JBrowse link
G C19h4orf51 similar to human chromosome 4 open reading frame 51 decreases expression ISO Rifampin results in decreased expression of C4ORF51 mRNA CTD PMID:24552687 NCBI chr19:45,573,267...45,608,796
Ensembl chr19:45,573,330...45,608,796
JBrowse link
G Ca1 carbonic anhydrase 1 decreases expression ISO Rifampin results in decreased expression of CA1 mRNA CTD PMID:24552687 NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Rifampin inhibits the reaction [Rotenone results in increased cleavage of CASP1 protein] CTD PMID:26086368 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased activity of CASP3 protein]]; Rifampin inhibits the reaction [[Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of CASP3 protein]; Rifampin inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; Rifampin inhibits the reaction [FAS protein results in increased activity of CASP3 protein]; Rifampin inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]; Rifampin promotes the reaction [Galactosamine results in increased activity of CASP3 protein]
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of CASP3
[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein; HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]
CTD PMID:11958592 PMID:12645856 PMID:17936189 PMID:21419764 PMID:23764483 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased activity of CASP8 protein]]; Rifampin inhibits the reaction [FAS protein results in increased activity of CASP8 protein] CTD PMID:11958592 PMID:12645856 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
JBrowse link
G Cat catalase multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of CAT protein CTD PMID:36878459 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Cbr3 carbonyl reductase 3 multiple interactions ISO [Rifampin co-treated with Cobicistat] results in increased expression of CBR3 mRNA CTD PMID:33629115 NCBI chr11:46,478,295...46,486,555
Ensembl chr11:46,478,274...46,486,558
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Rifampin results in decreased expression of CCL2 mRNA CTD PMID:25051504 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression EXP Rifampin results in decreased expression of CCL5 protein CTD PMID:25051504 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of CCN1 mRNA CTD PMID:21127053 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA CTD PMID:21224054 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA CTD PMID:21224054 NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of CCR6 mRNA CTD PMID:21127053 NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:55,021,833...55,046,059
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of CCR7 mRNA CTD PMID:21127053 NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,593,594...84,604,501
JBrowse link
G Cd36 CD36 molecule increases expression ISO Rifampin results in increased expression of CD36 mRNA CTD PMID:27806127 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein CTD PMID:21224054 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of CDKN2B mRNA CTD PMID:21127053 NCBI chr 5:109,123,308...109,134,906
Ensembl chr 5:109,114,322...109,134,855
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO [Rifampin affects the susceptibility to Dietary Fats] which results in decreased expression of CEBPA mRNA; Rifampin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of CEBPA mRNA]; Rifampin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of CEBPA protein] CTD PMID:33412187 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO [Rifampin affects the susceptibility to Dietary Fats] which results in decreased expression of CEBPB mRNA; Rifampin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of CEBPB mRNA]; Rifampin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of CEBPB protein] CTD PMID:33412187 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO [Rifampin affects the susceptibility to Dietary Fats] which results in decreased expression of CEBPD mRNA; Rifampin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of CEBPD mRNA] CTD PMID:33412187 NCBI chr11:98,268,856...98,269,994
Ensembl chr11:98,265,651...98,280,824
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO Rifampin results in increased expression of CES1 protein CTD PMID:10640517 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449
JBrowse link
G Ces2h carboxylesterase 2H increases expression
multiple interactions
ISO Rifampin results in increased expression of CES2 mRNA; Rifampin results in increased expression of CES2 protein
Dichlororibofuranosylbenzimidazole inhibits the reaction [Rifampin results in increased expression of CES2 mRNA]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of CES2 mRNA]
CTD PMID:10640517 PMID:17003103 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
increases expression
ISO Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased expression of CFLAR protein modified form]]; Rifampin inhibits the reaction [FAS protein results in increased expression of CFLAR protein modified form]
Rifampin results in increased expression of CFLAR protein
CTD PMID:11958592 PMID:12645856 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA CTD PMID:21224054 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667
JBrowse link
G Ciz1 CDKN1A interacting zinc finger protein 1 decreases expression ISO Rifampin results in decreased expression of CIZ1 mRNA CTD PMID:24552687 NCBI chr 3:36,055,753...36,071,510
Ensembl chr 3:36,056,370...36,075,192
JBrowse link
G Clk2 CDC-like kinase 2 decreases expression ISO Rifampin results in decreased expression of CLK2 mRNA CTD PMID:24552687 NCBI chr 2:176,868,423...176,880,412
Ensembl chr 2:176,869,490...176,880,411
JBrowse link
G Cntln centlein increases expression ISO Rifampin results in increased expression of CNTLN mRNA CTD PMID:24552687 NCBI chr 5:104,340,801...104,622,491
Ensembl chr 5:104,342,173...104,630,976
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO Rifampin results in increased expression of CPT1A mRNA CTD PMID:27806127 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 decreases expression ISO Rifampin results in decreased expression of CRHR1 mRNA CTD PMID:24552687 NCBI chr10:89,540,192...89,583,466
Ensembl chr10:89,540,192...89,583,466
JBrowse link
G Crp C-reactive protein multiple interactions ISO [Floxacillin co-treated with Gentamicins co-treated with Rifampin] results in increased expression of CRP protein CTD PMID:16943303 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514
JBrowse link
G Csnk1g1 casein kinase 1, gamma 1 decreases expression ISO Rifampin results in decreased expression of CSNK1G1 mRNA CTD PMID:24552687 NCBI chr 8:75,334,751...75,472,339
Ensembl chr 8:75,334,895...75,467,515
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Rifampin results in increased expression of CXCL1 protein CTD PMID:25051504 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
affects expression
ISO
EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA
Rifampin affects the expression of CXCL10 protein
CTD PMID:21224054 PMID:25051504 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261
JBrowse link
G Cyb5rl cytochrome b5 reductase-like increases expression ISO Rifampin results in increased expression of CYB5RL mRNA CTD PMID:24552687 NCBI chr 5:127,075,034...127,097,551
Ensembl chr 5:127,074,535...127,097,518
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression
EXP
ISO
Rifampin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Rifampin results in increased activity of CYP1A1 protein
Rifampin results in increased expression of CYP1A1 mRNA; Rifampin results in increased expression of CYP1A1 protein
[Methylcholanthrene co-treated with Rifampin co-treated with Phenobarbital] results in increased expression of CYP1A1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP1A1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP1A1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP1A1 protein; [Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of CYP1A1 mRNA; Rifampin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CTD PMID:12040753 PMID:18493746 PMID:19118567 PMID:19409404 PMID:22733800 More... NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
ISO
EXP
[Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of CYP1A2 mRNA; Rifampin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
Rifampin results in increased expression of CYP1A2 mRNA; Rifampin results in increased expression of CYP1A2 protein
[[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in decreased expression of CYP1A2 protein; [Isoniazid co-treated with Rifampin] results in decreased expression of CYP1A2 mRNA; [Isoniazid co-treated with Rifampin] results in decreased expression of CYP1A2 protein; dendrobine inhibits the reaction [[Isoniazid co-treated with Rifampin] results in decreased expression of CYP1A2 mRNA]; dendrobine inhibits the reaction [[Isoniazid co-treated with Rifampin] results in decreased expression of CYP1A2 protein]
CTD PMID:15977188 PMID:17590308 PMID:18493746 PMID:25835148 PMID:29162470 More... NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA
[Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of CYP1B1 mRNA
CTD PMID:21224054 PMID:29162470 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
ISO NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP24A1 mRNA]; Rifampin promotes the reaction [NR1I2 protein binds to CYP24A1 promoter]
Rifampin results in increased activity of CYP24A1 protein
CTD PMID:15630458 PMID:21127053 NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:179,694,647...179,709,083
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP26A1 mRNA CTD PMID:21127053 NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:244,883,752...244,887,657
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO Rifampin promotes the reaction [[NR1I2 protein binds to NCOA1 protein] which binds to CYP27A1 gene]
Rifampin results in increased expression of CYP27A1 mRNA
CTD PMID:17088262 NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases expression
decreases expression
EXP
ISO
Rifampin results in increased expression of CYP2A1 mRNA
Rifampin results in increased expression of CYP2A13 mRNA
Rifampin results in decreased expression of CYP2A13 mRNA
CTD PMID:19118567 PMID:22258563 NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:91,359,272...91,389,730
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression ISO Rifampin results in increased expression of CYP2A4 mRNA CTD PMID:30503582 NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:91,299,561...91,307,649
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
multiple interactions
increases expression
ISO Rifampin results in increased activity of CYP2B6 protein
[[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in increased expression of CYP2B10 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA
Rifampin results in increased expression of CYP2B10 mRNA
Rifampin results in increased expression of CYP2B6 mRNA; Rifampin results in increased expression of CYP2B6 protein
[Rifampin co-treated with Monocrotophos] results in increased activity of CYP2B6 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 protein; [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP2B6 mRNA; [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of CYP2B6 mRNA; Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]]]; Dexamethasone promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]; GW 3965 inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]; NR1I2 mRNA promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]; NR1I2 protein affects the reaction [Rifampin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]; Rifampin results in increased expression of and results in increased activity of CYP2B6 protein
CTD PMID:12040753 PMID:12571232 PMID:12695351 PMID:14709624 PMID:14977870 More... NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression ISO Rifampin results in decreased expression of CYP2C18 mRNA; Rifampin results in decreased expression of CYP2C18 protein CTD PMID:22258563 PMID:31629065 NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853
JBrowse link
G Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2C23 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2C23 mRNA] CTD PMID:27919644 NCBI chr 1:252,838,427...252,863,081
Ensembl chr 1:252,838,433...252,863,067
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases activity
increases expression
multiple interactions
ISO Rifampin results in increased activity of CYP2C19 protein
Rifampin results in increased expression of CYP2C29 mRNA
[[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in increased expression of CYP2C protein
Rifampin results in increased expression of CYP2C19 mRNA; Rifampin results in increased expression of CYP2C19 protein
Rifampin results in increased expression of and results in increased activity of CYP2C19 protein
CTD PMID:12584154 PMID:14709624 PMID:15629111 PMID:17954527 PMID:19118567 More... NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects binding
multiple interactions
increases expression
increases activity
ISO [Rifampin binds to NR1I2 protein] which binds to CYP2C8 promoter
[Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP2C8 mRNA]; pimecrolimus inhibits the reaction [Rifampin results in increased expression of CYP2C8 mRNA]; Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]
Rifampin results in increased expression of CYP2C8 mRNA; Rifampin results in increased expression of CYP2C8 protein
Rifampin results in increased activity of CYP2C8 protein
CTD PMID:12040753 PMID:15771232 PMID:15933212 PMID:17954527 PMID:19118567 More...
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases expression
increases activity
decreases expression
ISO Rifampin results in increased expression of CYP2D6 mRNA
Rifampin results in increased activity of CYP2D6 protein
Rifampin results in decreased expression of CYP2D22 mRNA
CTD PMID:19041851 PMID:30503582 PMID:33844597 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity
decreases expression
multiple interactions
increases expression
ISO
EXP
Rifampin results in increased activity of CYP2E1 protein
Rifampin results in decreased expression of CYP2E1 mRNA
[[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in decreased expression of CYP2E1 protein; [Isoniazid co-treated with Rifampin co-treated with dendrobine] results in decreased expression of CYP2E1 mRNA; [Isoniazid co-treated with Rifampin] results in decreased expression of CYP2E1 mRNA
Rifampin results in increased expression of CYP2E1 mRNA; Rifampin results in increased expression of CYP2E1 protein
[Rifampin co-treated with Monocrotophos] results in increased activity of CYP2E1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 protein
[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; Rifampin inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]
CTD PMID:15132840 PMID:18071298 PMID:22258563 PMID:22733800 PMID:25835148 More... NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 decreases expression ISO Rifampin results in decreased expression of CYP2F1 mRNA CTD PMID:22258563 NCBI chr 1:91,543,768...91,557,553
Ensembl chr 1:91,543,768...91,557,553
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases expression ISO Rifampin results in decreased expression of CYP2J2 mRNA CTD PMID:33263786 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP2S1 mRNA CTD PMID:21127053 NCBI chr 1:90,437,741...90,453,073
Ensembl chr 1:90,438,224...90,453,073
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects activity
increases expression
decreases response to substance
increases activity
EXP
ISO
[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]; arsenite inhibits the reaction [Rifampin results in increased expression of and results in increased activity of CYP3A2 protein]; arsenite inhibits the reaction [Rifampin results in increased expression of CYP3A2 mRNA]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]; Rifampin results in increased expression of and results in increased activity of CYP3A2 protein
Rifampin affects the activity of CYP3A4 protein
Rifampin results in increased expression of CYP3A4; Rifampin results in increased expression of CYP3A4 mRNA; Rifampin results in increased expression of CYP3A4 mRNA alternative form; Rifampin results in increased expression of CYP3A4 protein
[[Rifampin results in increased activity of NR1I2 protein] which results in increased activity of CYP3A4 protein] which results in increased metabolism of and results in increased activity of and results in increased susceptibility to Cobicistat; [Dimethyl Sulfoxide results in increased susceptibility to Rifampin] which results in increased expression of CYP3A4 mRNA; [HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA; [Methylcholanthrene co-treated with Rifampin co-treated with Phenobarbital] results in increased expression of CYP3A4 mRNA; [NR1I2 protein binds to NCOR2 protein] inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; [NR1I2 protein co-treated with Rifampin] results in decreased expression of CYP3A4 mRNA; [PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA; [Rifampin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [Rifampin binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP3A4 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 protein; [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA; [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [Rifampin results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol; [Rifampin results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam; [Rifampin results in increased expression of CYP3A4 protein] which results in increased hydroxylation of Testosterone; [Rifampin results in increased expression of NR1I2 protein] which results in increased expression of and results in increased activity of CYP3A4 protein; [RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA; [SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA; [Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of CYP3A4 mRNA; AADAC mRNA affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein]; allyl isothiocyanate inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; Arsenic Trioxide inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; Calcitriol promotes the reaction [Rifampin results in increased activity of CYP3A4 protein]; Calcitriol promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; CYP3A4 protein inhibits the reaction [Rifampin results in decreased chemical synthesis of 1-hydroxymethylmidazolam]; CYP3A4 protein inhibits the reaction [Rifampin results in decreased chemical synthesis of 4-hydroxymidazolam]; CYP3A4 protein inhibits the reaction [Rifampin results in decreased hydroxylation of Midazolam]; Dexamethasone promotes the reaction [Rifampin results in increased activity of CYP3A4 protein]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Econazole promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Galactosamine inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; GW 3965 inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; lorlatinib inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein]; Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; NR1H3 mutant form inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; NR1I2 gene promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]; NR1I2 mRNA promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP3A4 protein]; NR1I2 protein inhibits the reaction [Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]; NR3C1 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; ochratoxin A inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; ochratoxin A inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; oxiconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; PRMT1 protein affects the reaction [[Dimethyl Sulfoxide results in increased susceptibility to Rifampin] which results in increased expression of CYP3A4 mRNA]; PRMT1 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; PRMT1 protein affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Rifampin binds to and results in increased activity of CYP3A4 protein; Rifampin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Rifampin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Rifampin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Rifampin promotes the reaction [[HNF4A co-treated with NCOA6] results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Rifampin promotes the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Rifampin promotes the reaction [CYP3A4 protein results in increased metabolism of Lidocaine]; Rifampin promotes the reaction [NR1I2 protein binds to CYP3A4 promoter]; Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; Rifampin results in increased expression of and results in increased activity of CYP3A4 protein; Skatole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Skatole inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; sodium arsenite inhibits the reaction [Rifampin results in increased expression of and results in increased activity of CYP3A4 protein]; sodium arsenite inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; sulforaphane inhibits the reaction [Rifampin results in increased expression of CYP3A4]; Tetrachlorodibenzodioxin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; trichostatin A affects the reaction [Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; trichostatin A promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]
CYP3A4 protein results in decreased susceptibility to Rifampin
[Rifampin results in increased activity of NR1I2 protein] which results in increased activity of CYP3A4 protein; Rifampin results in increased activity of CYP3A4 protein
Rifampin results in increased expression of CYP3A2 mRNA; Rifampin results in increased expression of CYP3A4 mRNA
CTD PMID:8632764 PMID:9298257 PMID:9512926 PMID:10219967 PMID:10640517 More... NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
increases expression
EXP [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP3A23-3A1 mRNA; arsenite inhibits the reaction [Rifampin results in increased expression of and results in increased activity of CYP3A23-3A1 protein]; arsenite inhibits the reaction [Rifampin results in increased expression of CYP3A23-3A1 mRNA]; Rifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to CYP3A23-3A1 promoter]; Rifampin results in increased expression of and results in increased activity of CYP3A23-3A1 protein; sodium arsenite inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:12370413 PMID:19041297 PMID:22159698 PMID:22310326 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression ISO Rifampin results in increased expression of CYP3A5 mRNA CTD PMID:12040753 PMID:12673034 PMID:15629111 PMID:15681896 PMID:19118567 More... NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
decreases expression
ISO
EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of CYP7A1 protein; NR1I2 protein promotes the reaction [Rifampin results in decreased expression of CYP7A1 mRNA]
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of CYP7A1 protein
CTD PMID:15629111 PMID:21127053 PMID:21224054 PMID:22258563 PMID:24259679 More... NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in decreased expression of CYP8B1 mRNA CTD PMID:21127053 NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689
JBrowse link
G Dcaf5 DDB1 and CUL4 associated factor 5 decreases expression ISO Rifampin results in decreased expression of DCAF5 mRNA CTD PMID:24552687 NCBI chr 6:104,904,423...104,993,150
Ensembl chr 6:104,904,423...104,993,103
JBrowse link
G Dclre1b DNA cross-link repair 1B decreases expression ISO Rifampin results in decreased expression of DCLRE1B mRNA CTD PMID:24552687 NCBI chr 2:193,998,350...194,006,873
Ensembl chr 2:193,998,354...194,006,864
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA; [Rifampin co-treated with Cobicistat] results in increased expression of DDIT3 mRNA
4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of DDIT3 mRNA]
Rifampin results in increased expression of DDIT3 mRNA; Rifampin results in increased expression of DDIT3 protein
CTD PMID:21224054 PMID:27470132 PMID:32535746 PMID:33629115 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase multiple interactions ISO [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of DHCR24 mRNA CTD PMID:22101211 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936
JBrowse link
G Dio1 iodothyronine deiodinase 1 increases expression ISO Rifampin results in increased expression of DIO1 mRNA CTD PMID:24552687 NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:127,303,083...127,319,771
JBrowse link
G Dlx4 distal-less homeobox 4 decreases expression ISO Rifampin results in decreased expression of DLX4 mRNA CTD PMID:24552687 NCBI chr10:80,581,878...80,587,272
Ensembl chr10:80,582,303...80,587,294
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA CTD PMID:21224054 NCBI chr 5:60,638,404...60,649,315
Ensembl chr 5:60,638,410...60,650,160
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA CTD PMID:21224054 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of EDN1 mRNA CTD PMID:21127053 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA
[Rifampin co-treated with NR1I2 protein] results in increased expression of EGR1 mRNA
CTD PMID:21127053 PMID:21224054 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843
JBrowse link
G Egr2 early growth response 2 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of EGR2 mRNA CTD PMID:21127053 NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748
JBrowse link
G Egr4 early growth response 4 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of EGR4 mRNA CTD PMID:21127053 NCBI chr 4:119,605,358...119,607,817
Ensembl chr 4:119,605,357...119,608,368
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
increases expression
multiple interactions
EXP
ISO
Rifampin results in increased phosphorylation of EIF2AK3 protein
Rifampin results in increased expression of EIF2AK3 mRNA; Rifampin results in increased expression of EIF2AK3 protein
4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 protein]
CTD PMID:24638036 PMID:27470132 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP Rifampin results in increased phosphorylation of EIF2S1 protein CTD PMID:24638036 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649
JBrowse link
G Elk1 ETS transcription factor ELK1 decreases expression ISO Rifampin results in decreased expression of ELK1 mRNA CTD PMID:24552687 NCBI chr  X:3,692,367...3,709,252
Ensembl chr  X:3,693,293...3,709,249
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of EPAS1 mRNA CTD PMID:21127053 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression
multiple interactions
ISO Rifampin results in increased expression of EPHX1 mRNA
pimecrolimus inhibits the reaction [Rifampin results in increased expression of EPHX1 mRNA]
CTD PMID:22258563 PMID:25313206 PMID:29356861 NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases expression
ISO Rifampin results in increased expression of and results in increased phosphorylation of ERN1 protein
Rifampin results in increased expression of ERN1 mRNA
CTD PMID:32535746 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791
JBrowse link
G Etnppl ethanolamine-phosphate phospho-lyase increases expression ISO Rifampin results in increased expression of ETNPPL mRNA CTD PMID:24552687 NCBI chr 2:221,847,210...221,868,827
Ensembl chr 2:221,847,250...221,866,357
JBrowse link
G F13b coagulation factor XIII B chain increases expression ISO Rifampin results in increased expression of F13B mRNA CTD PMID:24552687 NCBI chr13:53,681,639...53,707,114
Ensembl chr13:53,681,622...53,707,300
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased activity of CASP3 protein]]; Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased activity of CASP8 protein]]; Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased expression of CFLAR protein modified form]]; Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased expression of FASLG protein]]; Rifampin inhibits the reaction [FAS protein results in increased activity of CASP3 protein]; Rifampin inhibits the reaction [FAS protein results in increased activity of CASP8 protein]; Rifampin inhibits the reaction [FAS protein results in increased expression of CFLAR protein modified form]; Rifampin inhibits the reaction [FAS protein results in increased expression of FASLG protein] CTD PMID:11958592 PMID:12645856 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
JBrowse link
G Faslg Fas ligand multiple interactions
decreases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA
Rifampin results in decreased expression of FASLG mRNA; Rifampin results in decreased expression of FASLG protein
Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased expression of FASLG protein]]; Rifampin inhibits the reaction [FAS protein results in increased expression of FASLG protein]
CTD PMID:11958592 PMID:12645856 PMID:21224054 PMID:24552687 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503
JBrowse link
G Fasn fatty acid synthase increases expression
affects expression
multiple interactions
ISO Rifampin results in increased expression of FASN mRNA
Rifampin affects the expression of FASN mRNA
pimecrolimus inhibits the reaction [Rifampin results in increased expression of FASN mRNA]
CTD PMID:27806127 PMID:29356861 PMID:34689256 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583
JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions
increases expression
ISO [Rifampin binds to and results in increased activity of NR1I2 protein] which results in increased expression of FGF19 mRNA
Rifampin results in increased expression of FGF19 mRNA
CTD PMID:17696253 NCBI chr 1:209,485,813...209,490,267
Ensembl chr 1:209,485,813...209,490,267
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA CTD PMID:21224054 NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874
JBrowse link
G Fmo4 flavin containing dimethylaniline monoxygenase 4 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA CTD PMID:21224054 NCBI chr13:77,687,909...77,706,100
Ensembl chr13:77,687,909...77,706,100
JBrowse link
G Foxa1 forkhead box A1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in decreased expression of FOXA1 mRNA CTD PMID:21127053 NCBI chr 6:80,838,380...80,871,195
Ensembl chr 6:80,800,960...80,871,191
JBrowse link
G Foxp1 forkhead box P1 increases expression ISO Rifampin results in increased expression of FOXP1 mRNA CTD PMID:24552687 NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:133,122,055...133,500,272
JBrowse link
G Fut1 fucosyltransferase 1 decreases expression ISO Rifampin results in decreased expression of FUT1 mRNA CTD PMID:24552687 NCBI chr 1:105,223,399...105,226,817
Ensembl chr 1:105,223,390...105,227,513
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions
decreases expression
affects expression
ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA; INS protein inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA]; SGK2 mutant form affects the reaction [Rifampin affects the expression of G6PC1 mRNA]; SGK2 mutant form inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA]
Rifampin results in decreased expression of G6PC1 mRNA
CTD PMID:24204015 PMID:34689256 NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA CTD PMID:21224054 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta multiple interactions ISO NR1I2 protein promotes the reaction [Rifampin results in increased expression of GADD45B mRNA] CTD PMID:21127053 NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718
JBrowse link
G Gata5 GATA binding protein 5 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in decreased expression of GATA5 mRNA CTD PMID:21127053 NCBI chr 3:187,796,140...187,804,327
Ensembl chr 3:187,796,142...187,804,327
JBrowse link
G Gck glucokinase decreases expression
multiple interactions
ISO Rifampin results in decreased expression of GCK protein
NR1I2 protein promotes the reaction [Rifampin results in decreased expression of GCK protein]
CTD PMID:26616219 NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949
JBrowse link
G Glis2 GLIS family zinc finger 2 increases expression ISO Rifampin results in increased expression of GLIS2 mRNA CTD PMID:24552687 NCBI chr10:11,457,594...11,484,948
Ensembl chr10:11,457,792...11,477,995
JBrowse link
G Gnal G protein subunit alpha L decreases expression ISO Rifampin results in decreased expression of GNAL mRNA CTD PMID:24552687 NCBI chr18:62,892,257...63,032,510
Ensembl chr18:62,892,226...63,043,129
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions
increases activity
ISO [Rifampin co-treated with Isoniazid] results in increased activity of GOT1 protein
Rifampin results in increased activity of GOT1 protein
CTD PMID:25886055 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
increases expression
ISO
EXP
4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of GPT protein]; [Rifampin co-treated with Acetaminophen] results in decreased activity of GPT protein
Rifampin results in increased activity of GPT protein
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPT protein; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein]
[Isoniazid co-treated with Rifampin] results in increased expression of GPT protein; [Rifampin co-treated with Isoniazid] results in increased activity of GPT protein; dendrobine inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased expression of GPT protein]; Rifampin inhibits the reaction [Acetaminophen results in increased expression of GPT protein]
CTD PMID:24685772 PMID:25886055 PMID:27470132 PMID:31678598 PMID:32633153 More... NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA; [Rifampin co-treated with Cobicistat] results in increased expression of GPX2 mRNA CTD PMID:21224054 PMID:33629115 NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 mRNA; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 protein] CTD PMID:36878459 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 decreases expression ISO Rifampin results in decreased expression of GRIA1 mRNA CTD PMID:24552687 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309
JBrowse link
G Gsr glutathione-disulfide reductase increases activity ISO Rifampin results in increased activity of GSR protein CTD PMID:20848779 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
increases expression
ISO [Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of GSTA1 mRNA; Ketoconazole inhibits the reaction [Rifampin results in increased expression of GSTA1 mRNA] CTD PMID:16608920 PMID:19118567 PMID:29162470 NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein CTD PMID:21224054 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA CTD PMID:21224054 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
ISO [Rifampin co-treated with Monocrotophos] results in increased expression of GSTP1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of GSTP1 protein
Rifampin results in increased expression of GSTP1 mRNA; Rifampin results in increased expression of GSTP1 protein
CTD PMID:22733800 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions ISO GSTT1 gene polymorphism affects the susceptibility to [Isoniazid co-treated with Rifampin]; GSTT1 gene polymorphism results in increased susceptibility to [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide] CTD PMID:18397238 PMID:20485159 NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,083...12,873,019
JBrowse link
G Gtf2ird2 GTF2I repeat domain containing 2 increases expression ISO Rifampin results in increased expression of GTF2IRD2 mRNA CTD PMID:24552687 NCBI chr12:28,134,199...28,179,089
Ensembl chr12:28,133,792...28,172,876
JBrowse link
G Gzmb granzyme B increases secretion ISO Rifampin results in increased secretion of GZMB protein CTD PMID:27933861 NCBI chr15:34,459,007...34,462,469
Ensembl chr15:34,459,007...34,462,469
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of HBEGF mRNA CTD PMID:21127053 NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,380,337...28,390,220
JBrowse link
G Hdac3 histone deacetylase 3 multiple interactions ISO Rifampin inhibits the reaction [trichostatin A inhibits the reaction [[PIAS1 co-treated with SUMO3] inhibits the reaction [NCOR2 protein promotes the reaction [NR1I2 protein binds to HDAC3 protein]]]] CTD PMID:26883953 NCBI chr18:30,021,847...30,041,061
Ensembl chr18:30,021,941...30,041,025
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in decreased expression of HDAC5 mRNA CTD PMID:21127053 NCBI chr10:87,653,139...87,688,078
Ensembl chr10:87,652,656...87,694,244
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of HEY1 mRNA CTD PMID:21127053 NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:95,002,943...95,007,624
JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased abundance of Reactive Oxygen Species]; HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein] CTD PMID:23764483 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO
EXP
[Rifampin co-treated with NR1I2 protein] results in increased expression of HIF1A mRNA
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of HIF1A mRNA; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of HIF1A protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 protein]; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 protein]; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein]
CTD PMID:21127053 PMID:36878459 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
JBrowse link
G Hmgn5 high mobility group nucleosome binding domain 5 increases expression ISO Rifampin results in increased expression of HMGN5 mRNA CTD PMID:24552687 NCBI chr  X:78,161,439...78,170,613
Ensembl chr  X:78,161,442...78,169,924
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA
dorsomorphin inhibits the reaction [Rifampin results in increased expression of HMOX1 protein]
Rifampin results in increased expression of HMOX1 mRNA; Rifampin results in increased expression of HMOX1 protein
[arsenite co-treated with Rifampin] results in increased expression of HMOX1 mRNA
CTD PMID:21224054 PMID:22159698 PMID:22258563 PMID:31678598 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions ISO [HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA; [Rifampin co-treated with NR1I2 protein] results in decreased expression of HNF4A mRNA; [Rifampin results in increased activity of NR1I2 protein] inhibits the reaction [HNF4A protein binds to SULT1E1 enhancer]; allyl isothiocyanate inhibits the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; NCOA6 promotes the reaction [Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP2C9 mRNA]]; NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; Rifampin inhibits the reaction [HNF4A protein binds to SULT1E1 enhancer]; Rifampin promotes the reaction [[HNF4A co-treated with NCOA6] results in increased expression of CYP2C9 mRNA]; Rifampin promotes the reaction [[HNF4A co-treated with NCOA6] results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP2C9 mRNA]; Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [MED1 protein binds to HNF4A protein]; Rifampin promotes the reaction [NCOA1 protein binds to HNF4A protein]; Rifampin promotes the reaction [NCOA2 protein binds to HNF4A protein]; Rifampin promotes the reaction [NCOA6 protein binds to HNF4A protein]; Rifampin promotes the reaction [NR1I2 protein binds to HNF4A protein]; Rifampin promotes the reaction [PPARGC1A protein binds to HNF4A protein] CTD PMID:21127053 PMID:21292004 PMID:21764778 PMID:25069801 NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758
JBrowse link
G Hrh1 histamine receptor H 1 increases expression ISO Rifampin results in increased expression of HRH1 mRNA CTD PMID:24552687 NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA CTD PMID:21224054 NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,853,331...3,876,877
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
EXP
ISO
ATF4 mutant form inhibits the reaction [Rifampin results in increased expression of HSPA5 protein]
[Rifampin co-treated with Cobicistat] results in increased expression of HSPA5 mRNA
4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of HSPA5 protein]
Rifampin results in increased expression of HSPA5 mRNA; Rifampin results in increased expression of HSPA5 protein
CTD PMID:24638036 PMID:27470132 PMID:32535746 PMID:33629115 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA CTD PMID:21224054 NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA CTD PMID:21224054 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA CTD PMID:21224054 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA CTD PMID:21224054 NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:64,085,068...64,087,502
JBrowse link
G Ifng interferon gamma increases secretion ISO Rifampin results in increased secretion of IFNG protein CTD PMID:27933861 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of IGFBP1 mRNA CTD PMID:21127053 NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of IGFBP3 mRNA CTD PMID:21127053 NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of IGFBP4 mRNA CTD PMID:21127053 NCBI chr10:84,491,471...84,503,487
Ensembl chr10:84,485,775...84,503,473
JBrowse link
G Il10 interleukin 10 affects expression EXP Rifampin affects the expression of IL10 protein CTD PMID:25051504 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 decreases expression ISO Rifampin results in decreased expression of IL12RB2 mRNA CTD PMID:24552687 NCBI chr 4:97,756,089...97,844,937
Ensembl chr 4:97,756,089...97,844,937
JBrowse link
G Il13 interleukin 13 increases secretion ISO Rifampin results in increased secretion of IL13 protein CTD PMID:27933861 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483
JBrowse link
G Il18 interleukin 18 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA CTD PMID:21224054 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; Rifampin inhibits the reaction [Rotenone results in increased expression of and results in increased secretion of IL1B protein]; Rifampin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]
Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]]; Rifampin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]
Rifampin results in decreased expression of IL1B mRNA; Rifampin results in decreased expression of IL1B protein
CTD PMID:21224054 PMID:25051504 PMID:26086368 PMID:31648047 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
increases expression
ISO
EXP
Rifampin results in decreased expression of IL6 protein
Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased expression of IL6 mRNA]]; Rifampin inhibits the reaction [Rotenone results in increased expression of IL6 mRNA]
Rifampin results in increased expression of IL6 protein
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA
CTD PMID:21224054 PMID:21357946 PMID:25051504 PMID:31648047 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Ino80d INO80 complex subunit D decreases expression ISO Rifampin results in decreased expression of INO80D mRNA CTD PMID:24552687 NCBI chr 9:71,940,941...72,007,879
Ensembl chr 9:71,951,031...72,040,232
JBrowse link
G Ins2 insulin 2 multiple interactions ISO INS protein inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA]
Rifampin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of CEBPA mRNA]; Rifampin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of CEBPA protein]; Rifampin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of CEBPB mRNA]; Rifampin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of CEBPB protein]; Rifampin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of CEBPD mRNA]; Rifampin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of PPARG mRNA alternative form]; Rifampin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of PPARG mRNA]; Rifampin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of PPARG protein]
CTD PMID:24204015 PMID:33412187 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805
JBrowse link
G Ints6 integrator complex subunit 6 decreases expression ISO Rifampin results in decreased expression of INTS6 mRNA CTD PMID:24552687 NCBI chr15:41,080,584...41,224,350
Ensembl chr15:41,109,125...41,197,519
JBrowse link
G Iqca1 IQ motif containing with AAA domain 1 decreases expression ISO Rifampin results in decreased expression of DRC11 mRNA CTD PMID:24552687 NCBI chr 9:98,074,389...98,190,233
Ensembl chr 9:98,073,887...98,190,066
JBrowse link
G Itgbl1 integrin subunit beta like 1 decreases expression ISO Rifampin results in decreased expression of ITGBL1 mRNA CTD PMID:24552687 NCBI chr15:107,186,792...107,448,335
Ensembl chr15:107,186,689...107,451,098
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of JUN mRNA CTD PMID:21127053 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
JBrowse link
G Kirrel3 kirre like nephrin family adhesion molecule 3 decreases expression ISO Rifampin results in decreased expression of KIRREL3 mRNA CTD PMID:24552687 NCBI chr 8:41,123,692...41,663,528
Ensembl chr 8:41,123,878...41,664,147
JBrowse link
G Klf2 KLF transcription factor 2 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of KLF2 mRNA CTD PMID:21127053 NCBI chr16:17,555,136...17,557,768
Ensembl chr16:17,555,136...17,557,768
JBrowse link
G Klf5 KLF transcription factor 5 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of KLF5 mRNA CTD PMID:21127053 NCBI chr15:82,472,081...82,487,267
Ensembl chr15:82,472,065...82,487,262
JBrowse link
G Klf6 KLF transcription factor 6 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of KLF6 mRNA CTD PMID:21127053 NCBI chr17:69,449,483...69,458,478
Ensembl chr17:69,441,493...69,498,601
JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO Rifampin results in increased expression of LDLR mRNA CTD PMID:27806127 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675
JBrowse link
G Lefty1 left right determination factor 1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of LEFTY1 mRNA CTD PMID:21127053 NCBI chr13:95,188,091...95,191,488
Ensembl chr13:95,188,091...95,191,488
JBrowse link
G Lep leptin increases expression EXP Rifampin results in increased expression of LEP protein CTD PMID:25051504 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
JBrowse link
G Ltk leukocyte receptor tyrosine kinase increases expression ISO Rifampin results in increased expression of LTK mRNA CTD PMID:24552687 NCBI chr 3:127,188,479...127,195,356
Ensembl chr 3:127,188,480...127,197,402
JBrowse link
G Maff MAF bZIP transcription factor F multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of MAFF mRNA CTD PMID:21127053 NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:112,791,416...112,804,147
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta decreases metabolic processing
multiple interactions
increases lipidation
ISO Rifampin results in decreased metabolism of MAP1LC3B protein
ATP6V0D1 protein affects the reaction [Rifampin inhibits the reaction [Rotenone results in increased lipidation of MAP1LC3B protein]]; Chloroquine promotes the reaction [Rifampin results in increased lipidation of MAP1LC3B protein]; Rifampin inhibits the reaction [Rotenone results in increased lipidation of MAP1LC3B protein]
CTD PMID:29908302 PMID:31648047 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased phosphorylation of MAPK8 protein]]; Rifampin inhibits the reaction [Rotenone results in increased phosphorylation of MAPK8 protein] CTD PMID:31648047 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases phosphorylation ISO Rifampin results in increased phosphorylation of MAPKAPK2 protein CTD PMID:21127053 NCBI chr13:45,066,027...45,112,326
Ensembl chr13:45,066,031...45,112,326
JBrowse link
G Mapre3 microtubule-associated protein, RP/EB family, member 3 increases expression ISO Rifampin results in increased expression of MAPRE3 mRNA CTD PMID:24552687 NCBI chr 6:31,233,736...31,278,626
Ensembl chr 6:31,233,736...31,278,775
JBrowse link
G Matn2 matrilin 2 increases expression ISO Rifampin results in increased expression of MATN2 mRNA CTD PMID:27177772 NCBI chr 7:67,380,140...67,529,767
Ensembl chr 7:67,380,168...67,530,153
JBrowse link
G Mbp myelin basic protein affects expression EXP Rifampin affects the expression of MBP mRNA CTD PMID:22954530 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein CTD PMID:31629065 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions
decreases expression
ISO Rifampin promotes the reaction [MED1 protein binds to and results in increased activity of NR1I2 protein]; Rifampin promotes the reaction [MED1 protein binds to HNF4A protein]
Rifampin results in decreased expression of MED1 mRNA
CTD PMID:21292004 PMID:22214767 PMID:24552687 NCBI chr10:83,641,851...83,685,560
Ensembl chr10:83,641,862...83,685,545
JBrowse link
G Minpp1 multiple inositol-polyphosphate phosphatase 1 increases expression ISO Rifampin results in increased expression of MINPP1 mRNA CTD PMID:24552687 NCBI chr 1:239,766,809...239,793,023
Ensembl chr 1:239,767,286...239,793,015
JBrowse link
G Mir143 microRNA 143 increases expression ISO Rifampin results in increased expression of MIR143 mRNA CTD PMID:24552687 NCBI chr18:57,371,349...57,371,453 JBrowse link
G Mir145 microRNA 145 increases expression ISO Rifampin results in increased expression of MIR145 mRNA CTD PMID:24552687 NCBI chr18:57,369,983...57,370,070 JBrowse link
G Mir148b microRNA 148b decreases expression ISO Rifampin results in decreased expression of MIR148B mRNA CTD PMID:24552687 NCBI chr 7:136,299,870...136,299,966
Ensembl chr 7:136,299,870...136,299,966
JBrowse link
G Mir15b microRNA 15b increases expression ISO Rifampin results in increased expression of MIR15B mRNA CTD PMID:24552687 NCBI chr 2:155,555,178...155,555,275
Ensembl chr 2:155,555,178...155,555,275
JBrowse link
G Mir186 microRNA 186 multiple interactions ISO [Isoniazid co-treated with Rifampin] results in increased expression of MIR186 mRNA CTD PMID:32633153 NCBI chr 2:249,241,650...249,241,735
Ensembl chr 2:249,241,650...249,241,735
JBrowse link
G Mir192 microRNA 192 decreases expression ISO Rifampin results in decreased expression of MIR192 mRNA CTD PMID:24552687 NCBI chr 1:212,994,209...212,994,318
Ensembl chr 1:212,994,209...212,994,318
JBrowse link
G Mir200a microRNA 200a increases expression ISO Rifampin results in increased expression of MIR200A mRNA CTD PMID:24552687 NCBI chr 5:171,930,717...171,930,805 JBrowse link
G Mir202 microRNA 202 increases expression ISO Rifampin results in increased expression of MIR202 mRNA CTD PMID:24552687 NCBI chr 1:204,184,345...204,184,416 JBrowse link
G Mir204 microRNA 204 increases expression ISO Rifampin results in increased expression of MIR204 mRNA CTD PMID:24552687 NCBI chr 1:229,743,461...229,743,570
Ensembl chr 1:229,743,461...229,743,570
JBrowse link
G Mir20b microRNA 20b increases expression ISO Rifampin results in increased expression of MIR20B mRNA CTD PMID:24552687 NCBI chr  X:137,343,197...137,343,268 JBrowse link
G Mir21 microRNA 21 increases expression ISO Rifampin results in increased expression of MIR21 mRNA CTD PMID:24552687 NCBI chr10:71,902,600...71,902,691 JBrowse link
G Mir212 microRNA 212 decreases expression ISO Rifampin results in decreased expression of MIR212 mRNA CTD PMID:24552687 NCBI chr10:60,521,740...60,521,850
Ensembl chr10:60,521,740...60,521,850
JBrowse link
G Mir22 microRNA 22 increases expression ISO Rifampin results in increased expression of MIR22 mRNA CTD PMID:24552687 NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,805,331...60,805,425
JBrowse link
G Mir26b microRNA 26b increases expression ISO Rifampin results in increased expression of MIR26B mRNA CTD PMID:24552687 NCBI chr 9:83,425,709...83,425,793
Ensembl chr 9:83,425,709...83,425,793
JBrowse link
G Mir296 microRNA 296 decreases expression ISO Rifampin results in decreased expression of MIR296 mRNA CTD PMID:24552687 NCBI chr 3:183,470,069...183,470,146 JBrowse link
G Mir29a microRNA 29a decreases expression ISO Rifampin results in decreased expression of MIR29A mRNA CTD PMID:24552687 NCBI chr 4:60,617,955...60,618,042 JBrowse link
G Mir31 microRNA 31 increases expression ISO Rifampin results in increased expression of MIR31 mRNA CTD PMID:24552687 NCBI chr 5:108,714,849...108,714,954 JBrowse link
G Mir328 microRNA 328 increases expression ISO Rifampin results in increased expression of MIR328 mRNA CTD PMID:24552687 NCBI chr19:50,094,691...50,094,774 JBrowse link
G Mir340 microRNA 340 increases expression ISO Rifampin results in increased expression of MIR340 mRNA CTD PMID:24552687 NCBI chr10:34,894,650...34,894,747
Ensembl chr10:34,894,650...34,894,747
JBrowse link
G Mir34a microRNA 34a decreases expression ISO Rifampin results in decreased expression of MIR34A mRNA CTD PMID:24552687 NCBI chr 5:165,815,952...165,816,053
Ensembl chr 5:165,815,952...165,816,053
JBrowse link
G Mir374b microRNA 374b increases expression ISO Rifampin results in increased expression of MIR374B mRNA CTD PMID:24552687 NCBI chr  X:72,657,495...72,657,562 JBrowse link
G Mir532 microRNA 532 decreases expression ISO Rifampin results in decreased expression of MIR532 mRNA CTD PMID:24552687 NCBI chr  X:17,919,185...17,919,263
Ensembl chr  X:17,919,185...17,919,263
JBrowse link
G Mir628 microRNA 628 decreases expression ISO Rifampin results in decreased expression of MIR628 mRNA CTD PMID:24552687 NCBI chr 8:82,620,496...82,620,579
Ensembl chr 8:82,620,496...82,620,579
JBrowse link
G Mir652 microRNA 652 decreases expression ISO Rifampin results in decreased expression of MIR652 mRNA CTD PMID:24552687 NCBI chr  X:111,140,079...111,140,159
Ensembl chr  X:111,140,079...111,140,159
JBrowse link
G Mir874 microRNA 874 decreases expression ISO Rifampin results in decreased expression of MIR874 mRNA CTD PMID:24552687 NCBI chr17:6,626,032...6,626,107
Ensembl chr17:6,626,032...6,626,107
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein CTD PMID:21224054 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases secretion ISO Rifampin results in decreased secretion of MMP3 protein CTD PMID:24890593 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Rifampin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:24101390 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Rifampin affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:69,850,420...69,868,302
Ensembl chr13:69,850,420...69,868,502
JBrowse link
G Mttp microsomal triglyceride transfer protein decreases expression ISO Rifampin results in decreased expression of MTTP mRNA CTD PMID:32535746 NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:229,286,501...229,327,650
JBrowse link
G Myh6 myosin heavy chain 6 increases expression ISO Rifampin results in increased expression of MYH6 mRNA CTD PMID:24552687 NCBI chr15:32,388,102...32,413,663
Ensembl chr15:32,387,487...32,411,333
JBrowse link
G Naf1 nuclear assembly factor 1 ribonucleoprotein decreases expression ISO Rifampin results in decreased expression of NAF1 mRNA CTD PMID:24552687 NCBI chr16:27,604,228...27,634,963
Ensembl chr16:27,603,918...27,634,963
JBrowse link
G Nap1l5 nucleosome assembly protein 1-like 5 increases expression ISO Rifampin results in increased expression of NAP1L5 mRNA CTD PMID:24552687 NCBI chr 4:89,352,834...89,354,704
Ensembl chr 4:89,351,926...89,361,736
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Camptothecin inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Itraconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Miconazole promotes the reaction [Rifampin results in increased expression of NCOA1 mRNA]; NCOA1 protein inhibits the reaction [[NR1I2 protein co-treated with Rifampin] results in decreased expression of SLC22A1 mRNA]; NCOA1 protein inhibits the reaction [[NR1I2 protein results in increased susceptibility to Rifampin] which results in decreased expression of SLC22A1 mRNA]; oxiconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; pazopanib inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; pimecrolimus inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Rifampin inhibits the reaction [NCOA1 protein binds to SLC22A1 promoter]; Rifampin inhibits the reaction [oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Rifampin promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [[NR1I2 protein binds to NCOA1 protein] which binds to CYP27A1 gene]; Rifampin promotes the reaction [NCOA1 protein binds to and results in increased activity of NR1I2 protein]; Rifampin promotes the reaction [NCOA1 protein binds to HNF4A protein]; Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]; Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein] CTD PMID:11581012 PMID:12072427 PMID:16819505 PMID:17088262 PMID:17438109 More... NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Rifampin promotes the reaction [NCOA2 protein binds to HNF4A protein] CTD PMID:21292004 NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776
JBrowse link
G Ncoa6 nuclear receptor coactivator 6 multiple interactions ISO NCOA6 promotes the reaction [Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP2C9 mRNA]]; Rifampin promotes the reaction [[HNF4A co-treated with NCOA6] results in increased expression of CYP2C9 mRNA]; Rifampin promotes the reaction [[HNF4A co-treated with NCOA6] results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [NCOA6 protein binds to HNF4A protein] CTD PMID:21292004 NCBI chr 3:164,351,062...164,422,079
Ensembl chr 3:164,351,062...164,421,991
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO Rifampin inhibits the reaction [NCOR1 protein binds to and results in decreased activity of NR1I2 protein] CTD PMID:22214767 NCBI chr10:47,498,852...47,641,612
Ensembl chr10:47,498,852...47,640,350
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO [NR1I2 protein binds to NCOR2 protein] inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Rifampin inhibits the reaction [NCOR2 protein binds to and results in decreased activity of NR1I2 protein]; Rifampin inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Rifampin inhibits the reaction [NR1I2 protein binds to NCOR2 protein]; Rifampin inhibits the reaction [trichostatin A inhibits the reaction [[PIAS1 co-treated with SUMO3] inhibits the reaction [NCOR2 protein promotes the reaction [NR1I2 protein binds to HDAC3 protein]]]]; Rifampin promotes the reaction [NR1I2 protein binds to NCOR2 protein] CTD PMID:12072427 PMID:22214767 PMID:25313206 PMID:26883953 PMID:28289823 More... NCBI chr12:37,127,736...37,289,612
Ensembl chr12:37,127,686...37,289,612
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
decreases expression
decreases activity
ISO
EXP
Rifampin results in increased expression of NFE2L2 protein
[tanshinone co-treated with Rifampin] results in increased expression of NFE2L2 mRNA; tanshinone inhibits the reaction [Rifampin results in decreased expression of NFE2L2 mRNA]; tanshinone inhibits the reaction [Rifampin results in decreased expression of NFE2L2 protein]
Rifampin results in decreased expression of NFE2L2 mRNA; Rifampin results in decreased expression of NFE2L2 protein
Rifampin inhibits the reaction [arsenite results in increased activity of NFE2L2 protein]
Rifampin results in decreased activity of NFE2L2 protein
CTD PMID:31678598 PMID:33307820 PMID:33412187 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nfya nuclear transcription factor Y subunit alpha decreases expression ISO Rifampin results in decreased expression of NFYA mRNA CTD PMID:24552687 NCBI chr 9:20,085,067...20,111,521
Ensembl chr 9:20,085,073...20,111,504
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Rifampin inhibits the reaction [Rotenone results in increased expression of NLRP3 protein] CTD PMID:26086368 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA
Rifampin results in increased expression of NOS2 mRNA
CTD PMID:21224054 PMID:24552687 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Npas1 neuronal PAS domain protein 1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of NPAS1 mRNA CTD PMID:21127053 NCBI chr 1:86,295,509...86,316,018
Ensembl chr 1:86,295,515...86,314,893
JBrowse link
G Nppb natriuretic peptide B multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of NPPB mRNA CTD PMID:21127053 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression
decreases expression
ISO Rifampin results in increased expression of NR0B2 mRNA
Rifampin results in decreased expression of NR0B2 mRNA
CTD PMID:15670600 PMID:34689256 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO NR1H3 mutant form inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] CTD PMID:23732298 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP
ISO
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of NR1H4 CTD PMID:35835356 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects response to substance
affects localization
decreases acetylation
increases response to substance
increases activity
decreases response to substance
multiple interactions
increases expression
increases localization
affects binding
ISO
EXP
NR1I2 protein affects the susceptibility to Rifampin
Rifampin affects the localization of NR1I2 protein
Rifampin results in decreased acetylation of NR1I2 protein
NR1I2 protein results in increased susceptibility to Rifampin
[Rifampin results in increased activity of NR1I2 protein] which results in increased activity of CYP3A4 protein; Rifampin results in increased activity of NR1I2 protein
NR1I2 protein mutant form results in decreased susceptibility to Rifampin
1,5-benzothiazepine analog promotes the reaction [[Rifampin co-treated with RXRA] results in increased activity of NR1I2 protein]; 7-acetoxy-6,7-dihydro-6-(4-methoxyphenyl)pyrrolo(2,1-d)(1,5)benzothiazepine inhibits the reaction [[Rifampin co-treated with RXRA] results in increased activity of NR1I2 protein]; [[Rifampin results in increased activity of NR1I2 protein] which results in increased activity of CYP3A4 protein] which results in increased metabolism of and results in increased activity of and results in increased susceptibility to Cobicistat; [fexofenadine co-treated with Rifampin] results in increased activity of NR1I2 protein; [Ketoconazole co-treated with Rifampin] results in increased activity of NR1I2 protein; [Loperamide co-treated with Rifampin] results in increased activity of NR1I2 protein; [NR1I2 protein binds to NCOR2 protein] inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; [NR1I2 protein co-treated with Rifampin] results in decreased expression of CYP3A4 mRNA; [NR1I2 protein co-treated with Rifampin] results in decreased expression of SLC22A1 mRNA; [NR1I2 protein co-treated with Rifampin] results in decreased expression of SULT1E1 mRNA; [NR1I2 protein results in increased susceptibility to Rifampin] which results in decreased expression of SLC22A1 mRNA; [NR1I2 protein results in increased susceptibility to Rifampin] which results in increased expression of ABCB1 mRNA; [NR1I2 protein results in increased susceptibility to Rifampin] which results in increased expression of ABCB1 protein; [NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin; [Rifampin binds to and results in increased activity of NR1I2 protein] promotes the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; [Rifampin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [Rifampin binds to and results in increased activity of NR1I2 protein] which results in increased expression of FGF19 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I2 protein; [Rifampin co-treated with NR1I2 protein] results in decreased expression of CYP8B1 mRNA; [Rifampin co-treated with NR1I2 protein] results in decreased expression of FOXA1 mRNA; [Rifampin co-treated with NR1I2 protein] results in decreased expression of GATA5 mRNA; [Rifampin co-treated with NR1I2 protein] results in decreased expression of HDAC5 mRNA; [Rifampin co-treated with NR1I2 protein] results in decreased expression of HNF4A mRNA; [Rifampin co-treated with NR1I2 protein] results in decreased expression of SERPINA4 mRNA; [Rifampin co-treated with NR1I2 protein] results in decreased expression of STAT5A mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of ANGPTL4 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of AQP3 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of BHLHE40 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of BMP4 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of CCN1 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of CCR6 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of CCR7 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of CDKN2B mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP26A1 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP2B6 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP2S1 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of EDN1 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of EGR1 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of EGR2 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of EGR4 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of EPAS1 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of HBEGF mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of HEY1 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of HIF1A mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of IGFBP1 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of IGFBP3 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of IGFBP4 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of JUN mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of KLF2 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of KLF5 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of KLF6 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of LEFTY1 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of MAFF mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of NPAS1 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of NPPB mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of PCK1 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of PIP4K2A mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of SERPINB1 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of SERPINB8 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of SERPINB9 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of SERPINE1 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of SGK2 protein; [Rifampin co-treated with NR1I2 protein] results in increased expression of SMAD9 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of SOCS3 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of UGT1A1 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of VEGFD mRNA; [Rifampin co-treated with RXRA] results in increased activity of NR1I2 protein; [Rifampin results in increased activity of NR1I2 protein] inhibits the reaction [HNF4A protein binds to SULT1E1 enhancer]; [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 protein; [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of CYP2B6 mRNA; [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of DHCR24 mRNA; [Rifampin results in increased expression of NR1I2 protein] which results in increased expression of and results in increased activity of CYP3A4 protein; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Camptothecin inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Camptothecin inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; caraway oil inhibits the reaction [Rifampin results in increased expression of NR1I2 mRNA]; Clove Oil inhibits the reaction [Rifampin results in increased expression of NR1I2 mRNA]; coriander oil inhibits the reaction [Rifampin results in increased expression of NR1I2 mRNA]; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]]]; Doxorubicin inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; enilconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; Epirubicin inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; Fluconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; hydroxyitraconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; INS protein inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA]; Itraconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Itraconazole promotes the reaction [Rifampin results in increased expression of NR1I2 mRNA]; jasmine oil inhibits the reaction [Rifampin results in increased expression of NR1I2 mRNA]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [Rifampin binds to and results in increased activity of NR1I2 protein]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; lemongrass oil inhibits the reaction [Rifampin results in increased expression of NR1I2 mRNA]; Miconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; mulberroside A inhibits the reaction [[NR1I2 protein results in increased susceptibility to Rifampin] which results in increased expression of ABCB1 mRNA]; mulberroside A inhibits the reaction [[NR1I2 protein results in increased susceptibility to Rifampin] which results in increased expression of ABCB1 protein]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; NCOA1 protein inhibits the reaction [[NR1I2 protein co-treated with Rifampin] results in decreased expression of SLC22A1 mRNA]; NCOA1 protein inhibits the reaction [[NR1I2 protein results in increased susceptibility to Rifampin] which results in decreased expression of SLC22A1 mRNA]; NCOA6 promotes the reaction [Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP2C9 mRNA]]; NR1I2 gene promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]; NR1I2 gene promotes the reaction [Rifampin results in increased metabolism of amprenavir]; NR1I2 gene promotes the reaction [Rifampin results in increased metabolism of Midazolam]; NR1I2 gene promotes the reaction [Rifampin results in increased metabolism of Nelfinavir]; NR1I2 gene promotes the reaction [Rifampin results in increased metabolism of Saquinavir]; NR1I2 mRNA promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]; NR1I2 mRNA promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; NR1I2 protein affects the reaction [Rifampin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP2C9 mRNA]; NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP3A4 protein]; NR1I2 protein inhibits the reaction [[Rifampin co-treated with Benzo(a)pyrene] results in increased expression of AHR mRNA]; NR1I2 protein inhibits the reaction [Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Rifampin results in decreased expression of CYP7A1 mRNA]; NR1I2 protein promotes the reaction [Rifampin results in decreased expression of GCK protein]; NR1I2 protein promotes the reaction [Rifampin results in decreased expression of SLC2A2 protein]; NR1I2 protein promotes the reaction [Rifampin results in increased abundance of Lipids]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of CES2 mRNA]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP24A1 mRNA]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of GADD45B mRNA]; ochratoxin A inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; Oils, Volatile inhibits the reaction [Rifampin results in increased expression of NR1I2 mRNA]; Oils, Volatile promotes the reaction [Rifampin results in increased expression of NR1I2 mRNA]; oxiconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]]; oxiconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; oxiconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; pazopanib inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; pazopanib inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; pimecrolimus inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; pimecrolimus inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; PK 11195 inhibits the reaction [[Rifampin co-treated with RXRA] results in increased activity of NR1I2 protein]; Rifampin binds to and results in increased activity of NR1I2 protein; Rifampin inhibits the reaction [NCOR1 protein binds to and results in decreased activity of NR1I2 protein]; Rifampin inhibits the reaction [NCOR2 protein binds to and results in decreased activity of NR1I2 protein]; Rifampin inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Rifampin inhibits the reaction [NR1I2 protein binds to NCOR2 protein]; Rifampin inhibits the reaction [oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Rifampin inhibits the reaction [oxiconazole results in increased expression of NR1I2 mRNA]; Rifampin inhibits the reaction [trichostatin A inhibits the reaction [[PIAS1 co-treated with SUMO3] inhibits the reaction [NCOR2 protein promotes the reaction [NR1I2 protein binds to HDAC3 protein]]]]; Rifampin inhibits the reaction [trichostatin A results in increased acetylation of NR1I2 protein]; Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP2C9 mRNA]; Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [[NR1I2 protein binds to NCOA1 protein] which binds to CYP27A1 gene]; Rifampin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [MED1 protein binds to and results in increased activity of NR1I2 protein]; Rifampin promotes the reaction [NCOA1 protein binds to and results in increased activity of NR1I2 protein]; Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]; Rifampin promotes the reaction [NR1I2 protein binds to ABCB1 promoter]; Rifampin promotes the reaction [NR1I2 protein binds to CYP24A1 promoter]; Rifampin promotes the reaction [NR1I2 protein binds to CYP2A6 promoter]; Rifampin promotes the reaction [NR1I2 protein binds to CYP3A4 promoter]; Rifampin promotes the reaction [NR1I2 protein binds to HNF4A protein]; Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Rifampin promotes the reaction [NR1I2 protein binds to NCOR2 protein]; Rifampin promotes the reaction [NR1I2 protein binds to SGK2 promoter]; Rifampin promotes the reaction [NR1I2 protein results in decreased expression of SLC22A1 mRNA]; Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP2C9 mRNA]; Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; SGK2 mutant form inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA]; SGK2 mutant form inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of PCK1 mRNA]; sodium arsenite inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; sulforaphane inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; trichostatin A affects the reaction [Rifampin affects the localization of NR1I2 protein]; triptolide inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]
Rifampin results in increased expression of NR1I2 mRNA; Rifampin results in increased expression of NR1I2 protein
Rifampin results in increased localization of NR1I2 protein
[Rifampin co-treated with NR1I2 protein] results in increased expression of CYP3A23-3A1 mRNA; [Rifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]] which results in increased expression of SULT2A1 mRNA; arsenite inhibits the reaction [Rifampin results in increased localization of NR1I2 protein]; Rifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to CYP3A23-3A1 promoter]; Rifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]; sodium arsenite inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of CYP3A23-3A1 mRNA]
Rifampin binds to NR1I2 gene mutant form
[[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in decreased expression of CYP1A2 protein; [[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in decreased expression of CYP2E1 protein; [[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in increased expression of CYP2B10 protein; [[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in increased expression of CYP2C protein; [[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in increased expression of CYP3A11 protein; [Rifampin binds to NR1I2 gene mutant form] which results in increased expression of CES2A mRNA; [Rifampin binds to NR1I2 gene mutant form] which results in increased expression of CYP3A11 mRNA; [Rifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]] which results in increased expression of SULT2A1 mRNA; NR1I2 affects the reaction [Rifampin results in increased activity of CYP3A4 protein]; Rifampin affects the localization of and results in increased activity of NR1I2 protein; Rifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]
[Rifampin binds to NR1I2 protein] which binds to CYP2C8 promoter; Rifampin binds to NR1I2 protein
CTD PMID:11581012 PMID:12065438 PMID:12072427 PMID:12370413 PMID:12417264 More... NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
multiple interactions
EXP
ISO
Rifampin results in increased expression of NR1I3 mRNA
[[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in decreased expression of CYP1A2 protein; [[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in decreased expression of CYP2E1 protein; [[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in increased expression of CYP2B10 protein; [[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in increased expression of CYP2C protein; [[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in increased expression of CYP3A11 protein
Rifampin results in increased expression of NR1I3 mRNA; Rifampin results in increased expression of NR1I3 protein
[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I3 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I3 protein
CTD PMID:19118567 PMID:22733800 PMID:25835148 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases expression
ISO Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]]]; NR3C1 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]
Rifampin results in increased expression of NR3C1 mRNA
CTD PMID:10219967 PMID:12673034 PMID:12695351 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843
JBrowse link
G Nrl neural retina leucine zipper increases expression ISO Rifampin results in increased expression of NRL mRNA CTD PMID:24552687 NCBI chr15:32,977,023...32,981,442
Ensembl chr15:32,977,035...32,981,442
JBrowse link
G Obsl1 obscurin like cytoskeletal adaptor 1 decreases expression ISO Rifampin results in decreased expression of OBSL1 mRNA CTD PMID:24552687 NCBI chr 9:84,416,447...84,442,415
Ensembl chr 9:84,416,240...84,442,415
JBrowse link
G Ocln occludin affects localization ISO Rifampin affects the localization of OCLN protein CTD PMID:19577586 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411
JBrowse link
G Or4a47 olfactory receptor family 4 subfamily A member 47 decreases expression ISO Rifampin results in decreased expression of OR4A47 mRNA CTD PMID:24552687 NCBI chr 3:96,330,089...96,331,018
Ensembl chr 3:96,330,089...96,331,018
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta decreases expression ISO Rifampin results in decreased expression of P4HB mRNA CTD PMID:32535746 NCBI chr10:106,335,300...106,346,911
Ensembl chr10:106,335,300...106,346,911
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Rifampin inhibits the reaction [[Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of PARP1 protein] CTD PMID:31678598 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
JBrowse link
G Pax7 paired box 7 decreases expression ISO Rifampin results in decreased expression of PAX7 mRNA CTD PMID:24552687 NCBI chr 5:157,279,623...157,381,188
Ensembl chr 5:157,279,623...157,381,121
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
increases expression
ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of PCK1 mRNA; SGK2 mutant form inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of PCK1 mRNA]
Rifampin results in increased expression of PCK1 mRNA
CTD PMID:24204015 PMID:34689256 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561
JBrowse link
G Pclaf PCNA clamp associated factor increases expression ISO Rifampin results in increased expression of PCLAF mRNA CTD PMID:24552687 NCBI chr 8:75,311,028...75,328,108
Ensembl chr 8:75,315,707...75,328,106
JBrowse link
G Pdap1 PDGFA associated protein 1 decreases expression ISO Rifampin results in decreased expression of PDAP1 mRNA CTD PMID:24552687 NCBI chr12:14,584,414...14,594,641
Ensembl chr12:14,584,398...14,594,641
JBrowse link
G Pde4d phosphodiesterase 4D decreases expression ISO Rifampin results in decreased expression of PDE4D mRNA CTD PMID:24552687 NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:42,110,838...43,262,569
JBrowse link
G Peg3 paternally expressed 3 increases expression ISO Rifampin results in increased expression of PEG3 mRNA CTD PMID:24552687 NCBI chr 1:76,130,965...76,157,774
Ensembl chr 1:76,130,948...76,157,743
JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 multiple interactions ISO Rifampin inhibits the reaction [trichostatin A inhibits the reaction [[PIAS1 co-treated with SUMO3] inhibits the reaction [NCOR2 protein promotes the reaction [NR1I2 protein binds to HDAC3 protein]]]] CTD PMID:26883953 NCBI chr 8:72,233,566...72,347,085
Ensembl chr 8:72,233,566...72,334,315
JBrowse link
G Pilra paired immunoglobin-like type 2 receptor alpha decreases expression ISO Rifampin results in decreased expression of PILRA mRNA CTD PMID:24552687 NCBI chr12:23,452,626...23,464,772 JBrowse link
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of PIP4K2A mRNA CTD PMID:21127053 NCBI chr17:86,405,080...86,576,597
Ensembl chr17:86,405,081...86,576,430
JBrowse link
G Pkd2l1 polycystin 2 like 1, transient receptor potential cation channel decreases expression ISO Rifampin results in decreased expression of PKD2L1 mRNA CTD PMID:24552687 NCBI chr 1:252,982,096...253,019,235
Ensembl chr 1:252,982,096...253,023,359
JBrowse link
G Pklr pyruvate kinase L/R increases expression ISO Rifampin results in increased expression of PKLR mRNA CTD PMID:24552687 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644
JBrowse link
G Plat plasminogen activator, tissue type decreases expression ISO Rifampin results in decreased expression of PLAT mRNA CTD PMID:24552687 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696
JBrowse link
G Pon1 paraoxonase 1 increases expression ISO Rifampin results in increased expression of PON1 mRNA CTD PMID:26434531 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924
JBrowse link
G Por cytochrome p450 oxidoreductase increases activity ISO Rifampin results in increased activity of POR protein CTD PMID:12051692 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809
JBrowse link
G Pou2f1 POU class 2 homeobox 1 decreases expression ISO Rifampin results in decreased expression of POU2F1 mRNA CTD PMID:16837569 NCBI chr13:80,653,602...80,796,279
Ensembl chr13:80,663,714...80,796,356
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Rifampin co-treated with PPARA protein co-treated with RXRA protein] results in decreased expression of UGDH mRNA
[Isoniazid co-treated with Rifampin] results in decreased expression of PPARA protein
CTD PMID:16292757 PMID:36347327 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO [Isoniazid co-treated with Rifampin] results in decreased expression of PPARG protein; [Rifampin affects the susceptibility to Dietary Fats] which results in decreased expression of PPARG mRNA; [Rifampin affects the susceptibility to Dietary Fats] which results in decreased expression of PPARG mRNA alternative form; Rifampin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of PPARG mRNA alternative form]; Rifampin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of PPARG mRNA]; Rifampin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased expression of PPARG protein]; Rifampin results in increased expression of and affects the localization of PPARG protein
Rifampin results in increased expression of PPARG mRNA
CTD PMID:27806127 PMID:33412187 PMID:36347327 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA; allyl isothiocyanate inhibits the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [PPARGC1A protein binds to CYP2A6 promoter]; Rifampin promotes the reaction [PPARGC1A protein binds to HNF4A protein] CTD PMID:16857725 PMID:21292004 PMID:25069801 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2B9 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A14 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A11 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA; PRKDC gene mutant form results in increased susceptibility to [Rifampin co-treated with Phenytoin co-treated with Monocrotaline] CTD PMID:21224054 NCBI chr11:98,544,952...98,762,499
Ensembl chr11:98,544,954...98,762,108
JBrowse link
G Prmt1 protein arginine methyltransferase 1 multiple interactions ISO PRMT1 protein affects the reaction [[Dimethyl Sulfoxide results in increased susceptibility to Rifampin] which results in increased expression of CYP3A4 mRNA]; PRMT1 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; PRMT1 protein affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA] CTD PMID:31877331 NCBI chr 1:104,595,339...104,605,552
Ensembl chr 1:104,595,335...104,604,827
JBrowse link
G Prune1 prune exopolyphosphatase 1 decreases expression ISO Rifampin results in decreased expression of PRUNE1 mRNA CTD PMID:24552687 NCBI chr 2:185,519,569...185,548,402
Ensembl chr 2:185,520,781...185,548,402
JBrowse link
G Psip1 PC4 and SRSF1 interacting protein 1 increases expression ISO Rifampin results in increased expression of PSIP1 mRNA CTD PMID:24552687 NCBI chr 5:102,892,929...102,925,191
Ensembl chr 5:102,892,932...102,925,170
JBrowse link
G Psmc3ip PSMC3 interacting protein increases expression ISO Rifampin results in increased expression of PSMC3IP mRNA CTD PMID:24552687 NCBI chr10:86,524,546...86,527,764
Ensembl chr10:86,524,571...86,527,666
JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA CTD PMID:21224054 NCBI chr10:38,310,147...38,362,100
Ensembl chr10:38,310,147...38,362,100
JBrowse link
G Ric8b RIC8 guanine nucleotide exchange factor B decreases expression ISO Rifampin results in decreased expression of RIC8B mRNA CTD PMID:24552687 NCBI chr 7:20,636,337...20,730,066
Ensembl chr 7:20,636,687...20,730,178
JBrowse link
G Rnf6 ring finger protein 6 decreases expression ISO Rifampin results in decreased expression of RNF6 mRNA CTD PMID:24552687 NCBI chr12:13,929,160...13,940,663
Ensembl chr12:13,931,074...13,940,652
JBrowse link
G Rragb Ras-related GTP binding B decreases expression ISO Rifampin results in decreased expression of RRAGB mRNA CTD PMID:24552687 NCBI chr  X:21,560,313...21,610,550
Ensembl chr  X:21,560,361...21,610,346
JBrowse link
G Rspo3 R-spondin 3 decreases expression ISO Rifampin results in decreased expression of RSPO3 mRNA CTD PMID:24552687 NCBI chr 1:30,112,529...30,197,267
Ensembl chr 1:30,112,114...30,197,938
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Rifampin affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118
JBrowse link
G RT1-DMa RT1 class II, locus DMa increases expression ISO Rifampin results in increased expression of HLA-DMA mRNA CTD PMID:24552687 NCBI chr20:4,708,932...4,712,335
Ensembl chr20:4,708,933...4,712,335
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Rifampin affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,329,227...1,333,394
Ensembl chr20:1,329,225...1,333,366
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO
EXP
1,5-benzothiazepine analog promotes the reaction [[Rifampin co-treated with RXRA] results in increased activity of NR1I2 protein]; 7-acetoxy-6,7-dihydro-6-(4-methoxyphenyl)pyrrolo(2,1-d)(1,5)benzothiazepine inhibits the reaction [[Rifampin co-treated with RXRA] results in increased activity of NR1I2 protein]; [Rifampin co-treated with PPARA protein co-treated with RXRA protein] results in decreased expression of UGDH mRNA; [Rifampin co-treated with RXRA] results in increased activity of NR1I2 protein; [RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA; allyl isothiocyanate inhibits the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; PK 11195 inhibits the reaction [[Rifampin co-treated with RXRA] results in increased activity of NR1I2 protein]; Rifampin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]
[Rifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]] which results in increased expression of SULT2A1 mRNA; Rifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]
[Rifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]] which results in increased expression of SULT2A1 mRNA; Rifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to CYP3A23-3A1 promoter]; Rifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]
CTD PMID:12370413 PMID:16292757 PMID:16632523 PMID:21315811 PMID:25069801 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression ISO Rifampin results in decreased expression of SCARB1 mRNA; Rifampin results in decreased expression of SCARB1 protein CTD PMID:15883047 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Rifampin results in increased expression of SCD1 mRNA CTD PMID:27806127 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785
JBrowse link
G Septin8 septin 8 increases expression ISO Rifampin results in increased expression of SEPTIN8 mRNA CTD PMID:24552687 NCBI chr10:38,185,454...38,214,502
Ensembl chr10:38,185,335...38,214,504
JBrowse link
G Serpina4 serpin family A member 4 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in decreased expression of SERPINA4 mRNA CTD PMID:21127053 NCBI chr 6:128,764,738...128,773,858
Ensembl chr 6:128,764,769...128,776,028
JBrowse link
G Serpinb1a serpin family B member 1A multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of SERPINB1 mRNA CTD PMID:21127053 NCBI chr17:31,799,446...31,807,853
Ensembl chr17:31,799,415...31,808,166
JBrowse link
G Serpinb8 serpin family B member 8 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of SERPINB8 mRNA CTD PMID:21127053 NCBI chr13:24,141,557...24,164,894
Ensembl chr13:24,129,855...24,166,076
JBrowse link
G Serpinb9 serpin family B member 9 multiple interactions
increases expression
ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of SERPINB9 mRNA
Rifampin results in increased expression of SERPINB9 mRNA
CTD PMID:21127053 PMID:24552687 NCBI chr17:31,628,887...31,652,003
Ensembl chr17:31,629,392...31,651,974
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA
[Rifampin co-treated with NR1I2 protein] results in increased expression of SERPINE1 mRNA
CTD PMID:21127053 PMID:21224054 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357
JBrowse link
G Sfxn1 sideroflexin 1 decreases expression ISO Rifampin results in decreased expression of SFXN1 mRNA CTD PMID:24552687 NCBI chr17:10,491,315...10,527,793
Ensembl chr17:10,491,344...10,527,456
JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 multiple interactions
increases expression
ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA; [Rifampin co-treated with NR1I2 protein] results in increased expression of SGK2 protein; Rifampin promotes the reaction [NR1I2 protein binds to SGK2 promoter]; SGK2 mutant form affects the reaction [Rifampin affects the expression of G6PC1 mRNA]; SGK2 mutant form inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA]; SGK2 mutant form inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of PCK1 mRNA]
Rifampin results in increased expression of SGK2 mRNA
CTD PMID:21127053 PMID:24204015 NCBI chr 3:172,063,625...172,089,000
Ensembl chr 3:172,063,776...172,089,011
JBrowse link
G Sik2 salt-inducible kinase 2 decreases expression ISO Rifampin results in decreased expression of SIK2 mRNA CTD PMID:24552687 NCBI chr 8:60,121,913...60,221,707
Ensembl chr 8:60,121,913...60,221,818
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression
multiple interactions
ISO
EXP
Rifampin results in decreased expression of SLC10A1 mRNA
Rifampin results in decreased expression of SLC10A1 protein
[tanshinone co-treated with Rifampin] results in increased expression of SLC10A1 mRNA; [tanshinone co-treated with Rifampin] results in increased expression of SLC10A1 protein; tanshinone inhibits the reaction [Rifampin results in decreased expression of SLC10A1 protein]
[Rifampin co-treated with Isoniazid] results in decreased expression of SLC10A1 protein
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of SLC10A1
CTD PMID:16837569 PMID:25886055 PMID:33307820 PMID:35835356 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944
JBrowse link
G Slc13a5 solute carrier family 13 member 5 increases expression ISO Rifampin results in increased expression of SLC13A5 mRNA; Rifampin results in increased expression of SLC13A5 protein CTD PMID:25628225 PMID:27199754 NCBI chr10:57,364,806...57,389,500
Ensembl chr10:57,364,806...57,389,516
JBrowse link
G Slc15a1 solute carrier family 15 member 1 decreases expression ISO Rifampin results in decreased expression of SLC15A1 mRNA CTD PMID:27199754 NCBI chr15:104,944,461...104,991,316
Ensembl chr15:104,944,463...104,989,369
JBrowse link
G Slc16a12 solute carrier family 16, member 12 increases expression
decreases expression
ISO Rifampin results in increased expression of SLC16A12 mRNA
Rifampin results in decreased expression of SLC16A12 mRNA
CTD PMID:24552687 PMID:27199754 NCBI chr 1:241,597,165...241,674,821
Ensembl chr 1:241,599,066...241,674,743
JBrowse link
G Slc17a1 solute carrier family 17 member 1 decreases expression ISO Rifampin results in decreased expression of SLC17A1 mRNA CTD PMID:27199754 NCBI chr17:41,647,332...41,683,078
Ensembl chr17:41,649,919...41,681,174
JBrowse link
G Slc1a2 solute carrier family 1 member 2 decreases expression ISO Rifampin results in decreased expression of SLC1A2 mRNA CTD PMID:27199754 NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249
JBrowse link
G Slc20a2 solute carrier family 20 member 2 decreases expression ISO Rifampin results in decreased expression of SLC20A2 mRNA CTD PMID:27199754 NCBI chr16:76,163,315...76,253,881
Ensembl chr16:76,162,922...76,253,881
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases expression
multiple interactions
ISO Rifampin results in decreased expression of SLC22A1 mRNA; Rifampin results in decreased expression of SLC22A1 protein
[NR1I2 protein co-treated with Rifampin] results in decreased expression of SLC22A1 mRNA; [NR1I2 protein results in increased susceptibility to Rifampin] which results in decreased expression of SLC22A1 mRNA; NCOA1 protein inhibits the reaction [[NR1I2 protein co-treated with Rifampin] results in decreased expression of SLC22A1 mRNA]; NCOA1 protein inhibits the reaction [[NR1I2 protein results in increased susceptibility to Rifampin] which results in decreased expression of SLC22A1 mRNA]; Rifampin inhibits the reaction [NCOA1 protein binds to SLC22A1 promoter]; Rifampin promotes the reaction [NR1I2 protein results in decreased expression of SLC22A1 mRNA]
CTD PMID:26920453 PMID:27199754 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436
JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases expression ISO Rifampin results in decreased expression of SLC22A9 mRNA CTD PMID:27199754 NCBI chr 1:214,767,837...214,956,535
Ensembl chr 1:214,767,837...214,862,340
JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases expression ISO Rifampin results in decreased expression of SLC22A7 mRNA CTD PMID:16837569 PMID:27199754 NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681
JBrowse link
G Slc23a2 solute carrier family 23 member 2 increases expression ISO Rifampin results in increased expression of SLC23A2 mRNA CTD PMID:27199754 NCBI chr 3:139,755,583...139,913,304
Ensembl chr 3:139,755,584...139,847,343
JBrowse link
G Slc23a3 solute carrier family 23, member 3 decreases expression ISO Rifampin results in decreased expression of SLC23A3 mRNA CTD PMID:27199754 NCBI chr 9:84,071,286...84,081,951
Ensembl chr 9:84,071,471...84,080,037
JBrowse link
G Slc25a22 solute carrier family 25 member 22 increases expression ISO Rifampin results in increased expression of SLC25A22 mRNA CTD PMID:27199754 NCBI chr 1:205,954,713...205,966,188
Ensembl chr 1:205,958,032...205,965,877
JBrowse link
G Slc25a34 solute carrier family 25, member 34 decreases expression ISO Rifampin results in decreased expression of SLC25A34 mRNA CTD PMID:27199754 NCBI chr 5:159,215,120...159,219,892
Ensembl chr 5:159,215,120...159,219,892
JBrowse link
G Slc25a40 solute carrier family 25, member 40 decreases expression ISO Rifampin results in decreased expression of SLC25A40 mRNA CTD PMID:24552687 NCBI chr 4:26,544,288...26,631,439
Ensembl chr 4:26,544,290...26,631,383
JBrowse link
G Slc26a2 solute carrier family 26 member 2 decreases expression ISO Rifampin results in decreased expression of SLC26A2 mRNA CTD PMID:27199754 NCBI chr18:56,918,662...56,937,032
Ensembl chr18:56,923,337...56,937,012
JBrowse link
G Slc26a4 solute carrier family 26 member 4 decreases expression ISO Rifampin results in decreased expression of SLC26A4 mRNA CTD PMID:27199754 NCBI chr 6:53,835,102...53,873,968
Ensembl chr 6:53,835,110...53,873,216
JBrowse link
G Slc27a1 solute carrier family 27 member 1 increases expression ISO Rifampin results in increased expression of SLC27A1 mRNA CTD PMID:27806127 NCBI chr16:18,311,859...18,337,024
Ensembl chr16:18,313,015...18,330,045
JBrowse link
G Slc27a2 solute carrier family 27 member 2 increases expression ISO Rifampin results in increased expression of SLC27A2 mRNA CTD PMID:27199754 NCBI chr 3:134,258,101...134,295,581
Ensembl chr 3:134,258,101...134,295,581
JBrowse link
G Slc27a3 solute carrier family 27 member 3 decreases expression ISO Rifampin results in decreased expression of SLC27A3 mRNA CTD PMID:27199754 NCBI chr 2:178,150,835...178,155,503
Ensembl chr 2:178,150,835...178,155,503
JBrowse link
G Slc27a5 solute carrier family 27 member 5 increases expression ISO Rifampin results in increased expression of SLC27A5 mRNA CTD PMID:27199754 NCBI chr 1:82,688,742...82,699,335
Ensembl chr 1:82,688,750...82,699,358
JBrowse link
G Slc29a1 solute carrier family 29 member 1 increases expression ISO Rifampin results in increased expression of SLC29A1 mRNA CTD PMID:27199754 NCBI chr 9:22,897,099...22,911,640
Ensembl chr 9:22,902,471...22,914,620
JBrowse link
G Slc29a4 solute carrier family 29 member 4 increases expression ISO Rifampin results in increased expression of SLC29A4 mRNA CTD PMID:27199754 NCBI chr12:16,967,047...16,998,276
Ensembl chr12:16,967,047...16,988,338
JBrowse link
G Slc2a12 solute carrier family 2 member 12 increases expression ISO Rifampin results in increased expression of SLC2A12 mRNA CTD PMID:27199754 NCBI chr 1:24,623,558...24,683,577
Ensembl chr 1:24,589,707...24,694,290
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
decreases expression
ISO NR1I2 protein promotes the reaction [Rifampin results in decreased expression of SLC2A2 protein]
Rifampin results in decreased expression of SLC2A2 mRNA; Rifampin results in decreased expression of SLC2A2 protein
CTD PMID:26616219 PMID:27199754 PMID:34689256 NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467
JBrowse link
G Slc30a10 solute carrier family 30, member 10 decreases expression ISO Rifampin results in decreased expression of SLC30A10 mRNA CTD PMID:27199754 NCBI chr13:99,529,664...99,584,442
Ensembl chr13:99,529,790...99,544,213
JBrowse link
G Slc38a2 solute carrier family 38, member 2 decreases expression ISO Rifampin results in decreased expression of SLC38A2 mRNA CTD PMID:27199754 NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619
JBrowse link
G Slc3a1 solute carrier family 3 member 1 decreases expression ISO Rifampin results in decreased expression of SLC3A1 mRNA CTD PMID:27199754 NCBI chr 6:15,361,037...15,396,695
Ensembl chr 6:15,361,046...15,394,775
JBrowse link
G Slc46a3 solute carrier family 46, member 3 increases expression ISO Rifampin results in increased expression of SLC46A3 mRNA CTD PMID:27199754 NCBI chr12:12,176,776...12,193,256
Ensembl chr12:12,176,807...12,193,255
JBrowse link
G Slc47a1 solute carrier family 47 member 1 increases expression ISO Rifampin results in increased expression of SLC47A1 mRNA CTD PMID:27199754 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096
JBrowse link
G Slc51a solute carrier family 51 member A increases expression ISO Rifampin results in increased expression of SLC51A mRNA CTD PMID:27199754 NCBI chr11:81,804,141...81,818,539
Ensembl chr11:81,803,972...81,818,539
JBrowse link
G Slc51b SLC51 subunit beta increases expression ISO Rifampin results in increased expression of SLC51B mRNA CTD PMID:27199754 NCBI chr 8:74,827,047...74,835,109
Ensembl chr 8:74,827,047...74,835,109
JBrowse link
G Slc5a11 solute carrier family 5 member 11 increases expression ISO Rifampin results in increased expression of SLC5A11 mRNA CTD PMID:27199754 NCBI chr 1:187,166,609...187,226,291
Ensembl chr 1:187,166,811...187,282,848
JBrowse link
G Slc5a12 solute carrier family 5 member 12 increases expression ISO Rifampin results in increased expression of SLC5A12 mRNA CTD PMID:27199754 NCBI chr 3:117,633,885...117,683,966
Ensembl chr 3:117,633,887...117,682,963
JBrowse link
G Slc6a12 solute carrier family 6 member 12 increases expression ISO Rifampin results in increased expression of SLC6A12 mRNA CTD PMID:27199754 NCBI chr 4:156,257,518...156,275,870
Ensembl chr 4:156,254,208...156,275,879
JBrowse link
G Slc6a20a solute carrier family 6 member 20a increases expression ISO Rifampin results in increased expression of SLC6A20 mRNA CTD PMID:27199754 NCBI chr 8:132,159,768...132,200,016
Ensembl chr 8:132,158,915...132,200,008
JBrowse link
G Slc6a9 solute carrier family 6 member 9 increases expression ISO Rifampin results in increased expression of SLC6A9 mRNA CTD PMID:27199754 NCBI chr 5:136,660,022...136,694,173
Ensembl chr 5:136,659,948...136,694,172
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 mRNA; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 protein] CTD PMID:36878459 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695
JBrowse link
G Slc9a8 solute carrier family 9 member A8 increases expression ISO Rifampin results in increased expression of SLC9A8 mRNA CTD PMID:27199754 NCBI chr 3:176,559,658...176,617,510
Ensembl chr 3:176,567,124...176,617,511
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions
decreases activity
EXP
ISO
Rifampin inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]
Rifampin inhibits the reaction [SLCO1A4 protein results in increased uptake of epyrifenacil metabolite]
Rifampin results in decreased activity of SLCO1A4 protein
CTD PMID:11883641 PMID:34619012 NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
decreases activity
decreases expression
ISO Rifampin inhibits the reaction [SLCO1B3 protein results in increased import of cyanoginosin LR]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Docetaxel]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of epyrifenacil metabolite]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of fexofenadine]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Ursodeoxycholic Acid metabolite]
Rifampin inhibits the reaction [SLCO1B2 protein results in increased uptake of epyrifenacil metabolite]
Rifampin results in decreased activity of SLCO1B3 protein
Rifampin results in decreased expression of SLCO1B3 mRNA
CTD PMID:17369605 PMID:18180276 PMID:21256917 PMID:21430235 PMID:27199754 More... NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083
JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 decreases activity
multiple interactions
EXP Rifampin results in decreased activity of SLCO1B1 protein
[Rifampin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate
CTD PMID:32259555 NCBI chr 4:176,197,736...176,244,401
Ensembl chr 4:176,197,741...176,244,395
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 multiple interactions ISO Rifampin inhibits the reaction [decitabine results in increased expression of SLCO2A1 mRNA] CTD PMID:23137910 NCBI chr 8:112,467,739...112,551,923
Ensembl chr 8:112,467,160...112,551,921
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases expression
decreases expression
multiple interactions
ISO Rifampin results in increased expression of SLCO2B1 mRNA
Rifampin results in decreased expression of SLCO2B1 mRNA; Rifampin results in decreased expression of SLCO2B1 protein
Rifampin inhibits the reaction [Dextran Sulfate results in increased expression of SLCO2B1 mRNA]; Rifampin inhibits the reaction [Lipopolysaccharides results in increased expression of SLCO2B1 mRNA]; Rifampin inhibits the reaction [SLCO2B1 protein results in increased uptake of Mesalamine]; Rifampin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]
CTD PMID:21430235 PMID:27199754 PMID:38423481 NCBI chr 1:163,371,410...163,419,412
Ensembl chr 1:163,371,410...163,419,279
JBrowse link
G Slco4c1 solute carrier organic anion transporter family, member 4C1 increases expression ISO Rifampin results in increased expression of SLCO4C1 mRNA CTD PMID:27199754 NCBI chr 9:104,624,802...104,676,462
Ensembl chr 9:104,624,802...104,676,462
JBrowse link
G Smad9 SMAD family member 9 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of SMAD9 mRNA CTD PMID:21127053 NCBI chr 2:141,106,668...141,156,477
Ensembl chr 2:141,106,668...141,156,477
JBrowse link
G Snca synuclein alpha multiple interactions
increases sumoylation
EXP Rifampin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein modified form]; UBE2I affects the reaction [Rifampin results in increased sumoylation of SNCA protein] CTD PMID:17280646 PMID:28132806 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315
JBrowse link
G Snora71c small nucleolar RNA, H/ACA box 71C decreases expression ISO Rifampin results in decreased expression of SNORA71C mRNA CTD PMID:24552687 NCBI chr 3:167,437,646...167,437,777
Ensembl chr 3:167,437,646...167,437,777
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of SOCS3 mRNA CTD PMID:21127053 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825
JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 decreases expression ISO Rifampin results in decreased expression of SORBS1 mRNA CTD PMID:24552687 NCBI chr 1:249,057,324...249,279,703
Ensembl chr 1:249,057,324...249,279,608
JBrowse link
G Sptb spectrin, beta, erythrocytic increases expression ISO Rifampin results in increased expression of SPTB mRNA CTD PMID:24552687 NCBI chr 6:101,043,512...101,170,389
Ensembl chr 6:101,045,216...101,170,278
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Rifampin results in increased expression of SQSTM1 protein CTD PMID:29908302 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO [SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA; allyl isothiocyanate inhibits the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA] CTD PMID:25069801 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in decreased expression of STAT5A mRNA CTD PMID:21127053 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:86,285,547...86,310,184
JBrowse link
G Stk39 serine threonine kinase 39 increases expression ISO Rifampin results in increased expression of STK39 mRNA CTD PMID:24552687 NCBI chr 3:73,321,522...73,588,397
Ensembl chr 3:73,321,522...73,586,740
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO [NR1I2 protein co-treated with Rifampin] results in decreased expression of SULT1E1 mRNA; [Rifampin results in increased activity of NR1I2 protein] inhibits the reaction [HNF4A protein binds to SULT1E1 enhancer]; Rifampin inhibits the reaction [HNF4A protein binds to SULT1E1 enhancer] CTD PMID:21764778 NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,700,292...20,718,716
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions ISO
EXP
[Rifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter]] which results in increased expression of SULT2A1 mRNA; Rifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to SULT2A1 promoter] CTD PMID:12370413 NCBI chr 1:84,582,011...84,639,001 JBrowse link
G Sumo1 small ubiquitin-like modifier 1 increases expression EXP Rifampin results in increased expression of SUMO1 protein CTD PMID:28132806 NCBI chr 9:68,572,901...68,602,803
Ensembl chr 9:68,572,911...68,602,890
JBrowse link
G Sumo3 small ubiquitin-like modifier 3 multiple interactions ISO Rifampin inhibits the reaction [trichostatin A inhibits the reaction [[PIAS1 co-treated with SUMO3] inhibits the reaction [NCOR2 protein promotes the reaction [NR1I2 protein binds to HDAC3 protein]]]] CTD PMID:26883953 NCBI chr20:11,009,730...11,020,502
Ensembl chr20:11,009,734...11,020,287
JBrowse link
G Sun1 Sad1 and UNC84 domain containing 1 decreases expression ISO Rifampin results in decreased expression of SUN1 mRNA CTD PMID:24552687 NCBI chr12:20,510,230...20,555,123
Ensembl chr12:20,490,861...20,555,240
JBrowse link
G Tbata thymus, brain and testes associated decreases expression ISO Rifampin results in decreased expression of TBATA mRNA CTD PMID:24552687 NCBI chr20:29,660,904...29,677,971
Ensembl chr20:29,660,970...29,677,972
JBrowse link
G Tfec transcription factor EC increases expression ISO Rifampin results in increased expression of TFEC mRNA CTD PMID:24552687 NCBI chr 4:46,072,093...46,146,200
Ensembl chr 4:46,073,605...46,146,200
JBrowse link
G Thsd4 thrombospondin type 1 domain containing 4 increases expression ISO Rifampin results in increased expression of THSD4 mRNA CTD PMID:24552687 NCBI chr 8:69,280,397...69,880,144
Ensembl chr 8:69,284,646...69,917,342
JBrowse link
G Tjp1 tight junction protein 1 affects localization
decreases expression
ISO Rifampin affects the localization of TJP1 protein
Rifampin results in decreased expression of TJP1 mRNA
CTD PMID:19577586 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
JBrowse link
G Tjp2 tight junction protein 2 decreases expression ISO Rifampin results in decreased expression of TJP2 mRNA CTD PMID:19577586 NCBI chr 1:231,136,218...231,264,750
Ensembl chr 1:231,136,243...231,264,750
JBrowse link
G Tlr1 toll-like receptor 1 increases expression ISO Rifampin results in increased expression of TLR1 mRNA CTD PMID:24552687 NCBI chr14:43,737,761...43,750,389
Ensembl chr14:43,740,379...43,756,243
JBrowse link
G Tmem120b transmembrane protein 120B decreases expression ISO Rifampin results in decreased expression of TMEM120B mRNA CTD PMID:24552687 NCBI chr12:39,108,280...39,148,090
Ensembl chr12:39,108,280...39,148,090
JBrowse link
G Tmem145 transmembrane protein 145 increases expression ISO Rifampin results in increased expression of TMEM145 mRNA CTD PMID:24552687 NCBI chr 1:90,019,727...90,029,432
Ensembl chr 1:90,019,745...90,029,427
JBrowse link
G Tmem88 transmembrane protein 88 increases expression ISO Rifampin results in increased expression of TMEM88 mRNA CTD PMID:24552687 NCBI chr10:54,617,554...54,619,309
Ensembl chr10:54,617,630...54,619,438
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Rifampin results in decreased expression of TNF protein CTD PMID:21357946 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions ISO [Rifampin co-treated with Cobicistat] results in increased expression of TNFRSF10B mRNA CTD PMID:33629115 NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA CTD PMID:21224054 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA CTD PMID:21224054 NCBI chr19:50,046,057...50,048,158
Ensembl chr19:50,046,061...50,052,550
JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan increases expression ISO Rifampin results in increased expression of TSKU mRNA CTD PMID:24552687 PMID:27177772 NCBI chr 1:162,071,459...162,082,972
Ensembl chr 1:162,064,126...162,089,272
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I multiple interactions EXP UBE2I affects the reaction [Rifampin results in increased sumoylation of SNCA protein] CTD PMID:28132806 NCBI chr10:14,782,245...14,802,911
Ensembl chr10:70,199,041...70,199,866
Ensembl chr10:70,199,041...70,199,866
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase multiple interactions
increases expression
ISO [Rifampin co-treated with PPARA protein co-treated with RXRA protein] results in decreased expression of UGDH mRNA
Rifampin results in increased expression of UGDH mRNA
CTD PMID:16292757 NCBI chr14:43,202,480...43,226,002
Ensembl chr14:43,202,356...43,226,629
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression
increases expression
multiple interactions
ISO Rifampin affects the expression of UGT1A1 mRNA
Rifampin results in increased expression of UGT1A1 mRNA
[Rifampin co-treated with NR1I2 protein] results in increased expression of UGT1A1 mRNA; [Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of UGT1A1 mRNA
CTD PMID:15104253 PMID:15771232 PMID:15849716 PMID:18098064 PMID:22126990 More... NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression
multiple interactions
ISO Rifampin results in increased expression of UGT1A3 mRNA
pimecrolimus inhibits the reaction [Rifampin results in increased expression of UGT1A3 mRNA]
CTD PMID:25313206 PMID:29356861 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO Rifampin results in increased expression of UGT1A6 mRNA CTD PMID:18094037 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases expression ISO Rifampin results in increased expression of UGT1A9 mRNA; Rifampin results in increased expression of UGT1A9 protein CTD PMID:25070100 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Uhrf2 ubiquitin like with PHD and ring finger domains 2 decreases expression ISO Rifampin results in decreased expression of UHRF2 mRNA CTD PMID:24552687 NCBI chr 1:237,224,050...237,291,406
Ensembl chr 1:237,228,456...237,292,353
JBrowse link
G Ung uracil-DNA glycosylase multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA CTD PMID:21224054 NCBI chr12:48,145,838...48,154,789
Ensembl chr12:48,145,838...48,155,257
JBrowse link
G Usp17la2 ubiquitin specific peptidase 17-like a2 decreases expression ISO Rifampin results in decreased expression of USP17L2 mRNA CTD PMID:24552687 NCBI chr 1:168,563,281...168,567,056 JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP Rifampin results in increased expression of VEGFA protein CTD PMID:25051504 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
G Vegfd vascular endothelial growth factor D multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of VEGFD mRNA CTD PMID:21127053 NCBI chr  X:33,704,582...33,740,305
Ensembl chr  X:33,706,055...33,740,167
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 affects response to substance ISO VKORC1 alternative form affects the susceptibility to Rifampin CTD PMID:36789833 NCBI chr 1:191,932,969...191,935,490 JBrowse link
G Vwa1 von Willebrand factor A domain containing 1 decreases expression ISO Rifampin results in decreased expression of VWA1 mRNA CTD PMID:24552687 NCBI chr 5:171,659,694...171,664,880
Ensembl chr 5:171,659,698...171,664,880
JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression ISO Rifampin results in increased expression of XIAP protein CTD PMID:12645856 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA CTD PMID:21224054 NCBI chr 2:22,686,506...22,932,929
Ensembl chr 2:22,686,508...22,933,160
JBrowse link
G Zcchc13 zinc finger CCHC-type containing 13 decreases expression ISO Rifampin results in decreased expression of ZCCHC13 mRNA CTD PMID:24552687 NCBI chr  X:72,709,319...72,710,422
Ensembl chr  X:72,709,152...72,731,030
JBrowse link
G Zfp11 zinc finger protein 11 decreases expression ISO Rifampin results in decreased expression of ZNF546 mRNA CTD PMID:24552687 NCBI chr12:32,664,312...32,676,940
Ensembl chr12:32,650,373...32,677,739
JBrowse link
G Zfp451 zinc finger protein 451 decreases expression ISO Rifampin results in decreased expression of ZNF451 mRNA CTD PMID:24552687 NCBI chr 9:43,481,395...43,546,103
Ensembl chr 9:43,481,401...43,516,706
JBrowse link
G Zfp46 zinc finger protein 46 decreases expression ISO Rifampin results in decreased expression of ZNF436 mRNA CTD PMID:24552687 NCBI chr 5:153,802,887...153,813,388
Ensembl chr 5:153,802,834...153,812,941
JBrowse link
G Zfp462 zinc finger protein 462 decreases expression ISO Rifampin results in decreased expression of ZNF462 mRNA CTD PMID:24552687 NCBI chr 5:74,465,383...74,606,020
Ensembl chr 5:74,468,643...74,606,020
JBrowse link
G Zfp658 zinc finger protein 658 decreases expression ISO Rifampin results in decreased expression of ZNF782 mRNA CTD PMID:24552687 NCBI chr 1:103,129,001...103,143,510
Ensembl chr 1:103,129,101...103,142,366
JBrowse link
G Zfp873 zinc finger protein 873 increases expression ISO Rifampin results in increased expression of ZNF441 mRNA CTD PMID:24552687 NCBI chr 7:8,577,725...8,602,577
Ensembl chr 7:8,577,999...8,602,710
JBrowse link
saracatinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 multiple interactions EXP saracatinib inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CAV1 protein] CTD PMID:26357463 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740
JBrowse link
G Csk C-terminal Src kinase decreases activity
multiple interactions
ISO saracatinib results in decreased activity of CSK protein
saracatinib inhibits the reaction [CSK protein results in decreased expression of CYP7A1 mRNA]
CTD PMID:20371703 NCBI chr 8:66,925,650...66,944,861
Ensembl chr 8:66,925,651...66,930,274
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases oxidation ISO CYP1A2 protein results in increased oxidation of saracatinib CTD PMID:27769111 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions ISO saracatinib inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; saracatinib inhibits the reaction [lithocholic acid acetate results in increased expression of CYP24A1 mRNA] CTD PMID:20371703 NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:179,694,647...179,709,083
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases oxidation ISO CYP2D6 protein results in increased oxidation of saracatinib CTD PMID:27769111 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases oxidation ISO CYP3A4 protein results in increased oxidation of saracatinib CTD PMID:27769111 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression
multiple interactions
ISO saracatinib results in increased expression of CYP7A1 mRNA
saracatinib inhibits the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA]; saracatinib inhibits the reaction [CSK protein results in decreased expression of CYP7A1 mRNA]; saracatinib inhibits the reaction [lithocholic acid acetate results in decreased expression of CYP7A1 mRNA]
CTD PMID:20371703 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202
JBrowse link
G L1cam L1 cell adhesion molecule decreases phosphorylation ISO saracatinib results in decreased phosphorylation of L1CAM protein CTD PMID:29109170 NCBI chr  X:156,748,597...156,775,116
Ensembl chr  X:156,748,597...156,775,077
JBrowse link
G Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 decreases activity ISO saracatinib results in decreased activity of PKMYT1 protein CTD PMID:29941193 NCBI chr10:13,252,805...13,263,584
Ensembl chr10:13,252,816...13,264,263
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO saracatinib binds to and affects the activity of SRC protein CTD PMID:22470466 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO saracatinib inhibits the reaction [Calcitriol results in increased phosphorylation of VDR protein]; saracatinib inhibits the reaction [lithocholic acid acetate results in increased phosphorylation of VDR protein] CTD PMID:20371703 NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:130,866,745...130,916,757
JBrowse link
thiethylperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
JBrowse link
trifluoperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases activity ISO Trifluoperazine results in increased activity of ABCB1 protein CTD PMID:2900677 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Ache acetylcholinesterase multiple interactions
increases activity
decreases expression
EXP
ISO
energostim inhibits the reaction [Trifluoperazine results in decreased expression of ACHE protein]
Trifluoperazine results in increased activity of ACHE protein
CTD PMID:15232633 PMID:29614332 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP
ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:19233221 PMID:21544200 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Atg5 autophagy related 5 increases expression ISO Trifluoperazine results in increased expression of ATG5 protein CTD PMID:38360085 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821
JBrowse link
G Atp6v1h ATPase H+ transporting V1 subunit H multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA CTD PMID:28366621 NCBI chr 5:19,176,849...19,282,516
Ensembl chr 5:19,176,849...19,282,516
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Trifluoperazine results in increased expression of BAX protein CTD PMID:21475906 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Trifluoperazine results in decreased expression of BCL2 protein CTD PMID:21475906 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Becn1 beclin 1 increases expression ISO Trifluoperazine results in increased expression of BECN1 protein CTD PMID:38360085 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein] CTD PMID:19233221 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:21544200 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cd44 CD44 molecule multiple interactions ISO Trifluoperazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD44 protein] CTD PMID:9929743 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP
ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:21544200 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases oxidation ISO FMO2 protein results in increased oxidation of Trifluoperazine CTD PMID:26062974 NCBI chr13:77,755,131...77,777,597
Ensembl chr13:77,757,629...77,777,534
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO Trifluoperazine inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]] CTD PMID:15627515 NCBI chr20:1,469,779...1,499,352
Ensembl chr20:1,469,779...1,498,607
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 multiple interactions ISO Trifluoperazine inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]] CTD PMID:15627515 NCBI chr 5:65,743,073...66,083,695
Ensembl chr 5:65,743,073...66,083,695
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Trifluoperazine results in decreased expression of HIF1A protein CTD PMID:18822394 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Trifluoperazine inhibits the reaction [Hydrogen Peroxide results in decreased expression of IL12B protein] CTD PMID:16249388 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Trifluoperazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity EXP Trifluoperazine results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:40,004,693...40,445,043
Ensembl chr18:40,155,939...40,445,045
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA CTD PMID:28366621 NCBI chr16:83,058,131...83,082,843
Ensembl chr16:83,058,385...83,075,159
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Trifluoperazine inhibits the reaction [Dinoprost results in increased activity of MAPK1 protein] CTD PMID:11914123 PMID:21544200 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO
EXP
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK14 protein] CTD PMID:21544200 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Trifluoperazine inhibits the reaction [Dinoprost results in increased activity of MAPK3 protein] CTD PMID:11914123 PMID:21544200 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO
EXP
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein] CTD PMID:21544200 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO
EXP
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK9 protein] CTD PMID:21544200 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228
JBrowse link
G Mt1a metallothionein 1A increases expression EXP Trifluoperazine results in increased expression of MT1A mRNA CTD PMID:8128501 NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr  X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
EXP
ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]
Trifluoperazine analog results in decreased phosphorylation of MTOR protein; Trifluoperazine results in decreased phosphorylation of MTOR protein
STON2 protein inhibits the reaction [Trifluoperazine analog results in decreased phosphorylation of MTOR protein]
CTD PMID:21544200 PMID:36702439 PMID:38360085 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
JBrowse link
G Myl9 myosin light chain 9 multiple interactions EXP Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MYL9 protein]; Trifluoperazine inhibits the reaction [Ionomycin results in increased phosphorylation of MYL9 protein] CTD PMID:19233221 NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:165,742,046...165,748,410
JBrowse link
G Nefl neurofilament light chain multiple interactions EXP Trifluoperazine inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA] CTD PMID:31969611 NCBI chr15:46,477,330...46,481,203
Ensembl chr15:46,458,204...46,482,515
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO Trifluoperazine results in decreased activity of NR3C1 protein CTD PMID:7887964 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP
ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein] CTD PMID:21544200 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]] CTD PMID:28366621 NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase affects localization
multiple interactions
ISO Trifluoperazine affects the localization of PRKN protein
PRKN protein affects the reaction [Trifluoperazine affects the localization of PRKN protein]
CTD PMID:28366621 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304
JBrowse link
G Prl prolactin increases expression ISO Trifluoperazine results in increased expression of PRL protein CTD PMID:2136057 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO Trifluoperazine inhibits the reaction [Hydrogen Peroxide results in decreased localization of REL protein] CTD PMID:16249388 NCBI chr14:101,891,238...101,922,324
Ensembl chr14:101,891,243...101,921,938
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP
ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein] CTD PMID:21544200 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238
JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO Trifluoperazine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:31,039,865...31,051,671
Ensembl chr 6:31,040,017...31,051,670
JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO Trifluoperazine results in decreased expression of SQSTM1 protein CTD PMID:38360085 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
JBrowse link
G Ston2 stonin 2 decreases expression
multiple interactions
ISO Trifluoperazine analog results in decreased expression of STON2 protein
STON2 protein inhibits the reaction [Trifluoperazine analog results in decreased phosphorylation of MTOR protein]
CTD PMID:36702439 NCBI chr 6:116,291,898...116,441,391
Ensembl chr 6:116,298,198...116,407,092
JBrowse link
G Tfeb transcription factor EB multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]] CTD PMID:28366621 NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:20,696,441...20,727,863
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases activity ISO Trifluoperazine results in decreased activity of TNFSF11 CTD PMID:21869564 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation
multiple interactions
increases activity
ISO UGT1A4 protein results in increased glucuronidation of Trifluoperazine
Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine]; hecogenin inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine]; licochalcone A inhibits the reaction [Trifluoperazine results in increased activity of UGT1A4 protein]; Trifluoperazine inhibits the reaction [UGT1A4 protein results in increased glucuronidation of afloqualone]
CTD PMID:15135306 PMID:15475412 PMID:25393417 PMID:25448279 PMID:26875642 More... NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases expression
increases phosphorylation
ISO Trifluoperazine results in increased expression of ULK1 mRNA
Trifluoperazine results in increased phosphorylation of ULK1 protein
CTD PMID:38360085 NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        NMR chemical shift reference compound 18453
          ammonia 18261
            organic amino compound 18261
              tertiary amino compound 11023
                N-methylpiperazine 1401
                  (2S,4S,5S)-5-[((2S)-2-\{(3R)-3-benzyl-4-[(4-methylpiperazin-1-yl)carbonyl]-2-oxopiperazin-1-yl\}hexanoyl)amino]-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide 0
                  (3E)-N-(2,6-diethylphenyl)-3-\{[4-(4-methylpiperazin-1-yl)benzoyl]imino\}pyrrolo[3,4-c]pyrazole-5(3H)-carboxamide 0
                  1-(3-(2,4-dimethylthiazol-5-yl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl)-3-(4-methylpiperazin-1-yl)urea 0
                  1-(4,4-dimethyl-1-piperazin-4-iumyl)ethanone 0
                  1-Methylpiperazine 0
                  1-[(2R,3R,6R)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-3-propylurea 0
                  1-[(2R,3R,6S)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-3-propylurea 0
                  1-[(2R,3S,6R)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-3-propylurea 0
                  1-[(2R,3S,6S)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-3-propylurea 0
                  1-[(2S,3R,6R)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-3-propylurea 0
                  1-[(2S,3R,6S)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-3-propylurea 0
                  1-[(2S,3S,6R)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-3-propylurea 0
                  1-[(2S,3S,6S)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-3-propylurea 0
                  1-[2-(1-adamantyl)ethoxy]-3-(4-methyl-1-piperazinyl)-2-propanol 0
                  2'-(3-iodo-4-methoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 0
                  2'-(3-iodophenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 0
                  2'-(3-methyl-4-dimethylaminophenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 0
                  2'-(4-dimethylaminophenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 0
                  2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 6
                  2'-(4-hydroxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 0
                  2,6-dimethylphenyl 2-\{3,5-dimethoxy-4-[3-(4-methylpiperazin-1-yl)propoxy]phenylamino\}pyrimidin-4-yl-(2,4-dimethoxyphenyl)carbamate 0
                  2-(3,4-dimethoxyphenyl)-9-[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]purine-6-carboxamide 0
                  2-(5-amino-4-cyano-1H-imidazol-1-yl)-5-(4-methylpiperazin-1-yl)benzoic acid 0
                  2-[(3R,6aR,8R,10aR)-3-hydroxy-1-(4-oxanylmethyl)-3,4,6,6a,8,9,10,10a-octahydro-2H-pyrano[2,3-c][1,5]oxazocin-8-yl]-1-(4-methyl-1-piperazinyl)ethanone 0
                  2-[(3R,6aR,8S,10aR)-3-hydroxy-1-(oxan-4-ylmethyl)-3,4,6,6a,8,9,10,10a-octahydro-2H-pyrano[2,3-c][1,5]oxazocin-8-yl]-1-(4-methylpiperazin-1-yl)ethanone 0
                  2-[(3R,6aS,8R,10aS)-3-hydroxy-1-(4-oxanylmethyl)-3,4,6,6a,8,9,10,10a-octahydro-2H-pyrano[2,3-c][1,5]oxazocin-8-yl]-1-(4-methyl-1-piperazinyl)ethanone 0
                  2-[(3R,6aS,8S,10aS)-3-hydroxy-1-(oxan-4-ylmethyl)-3,4,6,6a,8,9,10,10a-octahydro-2H-pyrano[2,3-c][1,5]oxazocin-8-yl]-1-(4-methylpiperazin-1-yl)ethanone 0
                  2-[(3S,6aR,8R,10aR)-3-hydroxy-1-(4-oxanylmethyl)-3,4,6,6a,8,9,10,10a-octahydro-2H-pyrano[2,3-c][1,5]oxazocin-8-yl]-1-(4-methyl-1-piperazinyl)ethanone 0
                  2-[(3S,6aR,8S,10aR)-3-hydroxy-1-(4-oxanylmethyl)-3,4,6,6a,8,9,10,10a-octahydro-2H-pyrano[2,3-c][1,5]oxazocin-8-yl]-1-(4-methyl-1-piperazinyl)ethanone 0
                  21-phosphorifampicin 0
                  3-\{6-[5-(4-methylpiperazin-1-yl)-1H-imidazo[4,5-b]pyridin-2-yl]-1H-benzimidazol-2-yl\}phenol 0
                  3-amino-7-(4-methylpiperazin-1-yl)-9-oxo-9H-imidazo[1,2-a]indole-2-carbonitrile 0
                  4-(4-methylpiperazin-1-yl)-N-[5-(2-thienylacetyl)-1,5-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide 0
                  4-(\{[(4-methylpiperazin-1-yl)amino]carbothioyl\}amino)benzenesulfonamide 0
                  4-[(4-methylpiperazin-1-yl)methyl]-N-\{3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl\}benzamide 0
                  4-methylpiperazine-1-carbaldehyde 0
                  6,7-dimethoxy-4-\{8-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydroisoquinolin-2-(1H)-yl\}quinazoline 0
                  6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)ethyl]-9H-purine-2-carbonitrile 0
                  9-cyclopentyl-6-\{2-[3-(4-methylpiperazin-1-yl)propoxy]phenylamino\}-9H-purine-2-carbonitrile 0
                  9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid + 210
                  ASP-3026 0
                  AZD2858 0
                  AZD5153 0
                  BI-4020 0
                  GSK461364 0
                  JTE-607 free base 0
                  LB42908 0
                  N-(4-\{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl\}-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide 0
                  N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)-2-(4-methylpiperazin-1-yl)pyridine-4-carboxamide 0
                  N-[(1S)-3-\{[(benzyloxy)amino]sulfonyl\}-1-(2-phenylethyl)propyl]-N-[(4-methylpiperazin-1-yl)carbonyl]-L-phenylalaninamide 0
                  N-[(2R,3R,6R)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-2-(2-pyridinyl)acetamide 0
                  N-[(2R,3R,6S)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-2-(2-pyridinyl)acetamide 0
                  N-[(2R,3S,6R)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-2-(2-pyridinyl)acetamide 0
                  N-[(2R,3S,6S)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-2-(2-pyridinyl)acetamide 0
                  N-[(2S,3R,6R)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-2-(2-pyridinyl)acetamide 0
                  N-[(2S,3R,6S)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-2-(2-pyridinyl)acetamide 0
                  N-[(2S,3S,6R)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-2-(2-pyridinyl)acetamide 0
                  N-[(2S,3S,6S)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-2-(2-pyridinyl)acetamide 0
                  N-[(3E)-5-[(2R)-2-methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3(5H)-ylidene]-4-(4-methylpiperazin-1-yl)benzamide 0
                  N-[(4-methylpiperazin-1-yl)carbonyl]-L-phenylalanin-(N-\{(1S)-3-phenyl-1-[2-(benzenesulfonyl)ethyl]propyl\})amide 0
                  N-\{4-[4-(4-methylpiperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-ylsulfanyl]phenyl\}cyclopropanecarboxamide 0
                  N-\{5-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl\}nicotinamide 0
                  PA-16-0081C 0
                  SU11274 0
                  Thiothixene 0
                  adavosertib 3
                  amocarzine 0
                  bosutinib + 26
                  clozapine 755
                  diethylcarbamazine 4
                  entrectinib 0
                  flumatinib 0
                  gilteritinib 0
                  imatinib + 2
                  methylpiperazinoforskolin 0
                  olanzapine 150
                  perazine + 4
                  pibenzimol + 6
                  pipebuzone 0
                  ponatinib 83
                  prochlorperazine + 3
                  rifampicin + 407
                  saracatinib 11
                  thiethylperazine + 2
                  thioproperazine 0
                  trifluoperazine + 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        tertiary amino compound 11023
                                          N-alkylpiperazine 3447
                                            N-methylpiperazine 1401
                                              (2S,4S,5S)-5-[((2S)-2-\{(3R)-3-benzyl-4-[(4-methylpiperazin-1-yl)carbonyl]-2-oxopiperazin-1-yl\}hexanoyl)amino]-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide 0
                                              (3E)-N-(2,6-diethylphenyl)-3-\{[4-(4-methylpiperazin-1-yl)benzoyl]imino\}pyrrolo[3,4-c]pyrazole-5(3H)-carboxamide 0
                                              1-(3-(2,4-dimethylthiazol-5-yl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl)-3-(4-methylpiperazin-1-yl)urea 0
                                              1-(4,4-dimethyl-1-piperazin-4-iumyl)ethanone 0
                                              1-Methylpiperazine 0
                                              1-[(2R,3R,6R)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-3-propylurea 0
                                              1-[(2R,3R,6S)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-3-propylurea 0
                                              1-[(2R,3S,6R)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-3-propylurea 0
                                              1-[(2R,3S,6S)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-3-propylurea 0
                                              1-[(2S,3R,6R)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-3-propylurea 0
                                              1-[(2S,3R,6S)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-3-propylurea 0
                                              1-[(2S,3S,6R)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-3-propylurea 0
                                              1-[(2S,3S,6S)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-3-propylurea 0
                                              1-[2-(1-adamantyl)ethoxy]-3-(4-methyl-1-piperazinyl)-2-propanol 0
                                              2'-(3-iodo-4-methoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 0
                                              2'-(3-iodophenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 0
                                              2'-(3-methyl-4-dimethylaminophenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 0
                                              2'-(4-dimethylaminophenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 0
                                              2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 6
                                              2'-(4-hydroxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole 0
                                              2,6-dimethylphenyl 2-\{3,5-dimethoxy-4-[3-(4-methylpiperazin-1-yl)propoxy]phenylamino\}pyrimidin-4-yl-(2,4-dimethoxyphenyl)carbamate 0
                                              2-(3,4-dimethoxyphenyl)-9-[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]purine-6-carboxamide 0
                                              2-(5-amino-4-cyano-1H-imidazol-1-yl)-5-(4-methylpiperazin-1-yl)benzoic acid 0
                                              2-[(3R,6aR,8R,10aR)-3-hydroxy-1-(4-oxanylmethyl)-3,4,6,6a,8,9,10,10a-octahydro-2H-pyrano[2,3-c][1,5]oxazocin-8-yl]-1-(4-methyl-1-piperazinyl)ethanone 0
                                              2-[(3R,6aR,8S,10aR)-3-hydroxy-1-(oxan-4-ylmethyl)-3,4,6,6a,8,9,10,10a-octahydro-2H-pyrano[2,3-c][1,5]oxazocin-8-yl]-1-(4-methylpiperazin-1-yl)ethanone 0
                                              2-[(3R,6aS,8R,10aS)-3-hydroxy-1-(4-oxanylmethyl)-3,4,6,6a,8,9,10,10a-octahydro-2H-pyrano[2,3-c][1,5]oxazocin-8-yl]-1-(4-methyl-1-piperazinyl)ethanone 0
                                              2-[(3R,6aS,8S,10aS)-3-hydroxy-1-(oxan-4-ylmethyl)-3,4,6,6a,8,9,10,10a-octahydro-2H-pyrano[2,3-c][1,5]oxazocin-8-yl]-1-(4-methylpiperazin-1-yl)ethanone 0
                                              2-[(3S,6aR,8R,10aR)-3-hydroxy-1-(4-oxanylmethyl)-3,4,6,6a,8,9,10,10a-octahydro-2H-pyrano[2,3-c][1,5]oxazocin-8-yl]-1-(4-methyl-1-piperazinyl)ethanone 0
                                              2-[(3S,6aR,8S,10aR)-3-hydroxy-1-(4-oxanylmethyl)-3,4,6,6a,8,9,10,10a-octahydro-2H-pyrano[2,3-c][1,5]oxazocin-8-yl]-1-(4-methyl-1-piperazinyl)ethanone 0
                                              21-phosphorifampicin 0
                                              3-\{6-[5-(4-methylpiperazin-1-yl)-1H-imidazo[4,5-b]pyridin-2-yl]-1H-benzimidazol-2-yl\}phenol 0
                                              3-amino-7-(4-methylpiperazin-1-yl)-9-oxo-9H-imidazo[1,2-a]indole-2-carbonitrile 0
                                              4-(4-methylpiperazin-1-yl)-N-[5-(2-thienylacetyl)-1,5-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide 0
                                              4-(\{[(4-methylpiperazin-1-yl)amino]carbothioyl\}amino)benzenesulfonamide 0
                                              4-[(4-methylpiperazin-1-yl)methyl]-N-\{3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl\}benzamide 0
                                              4-methylpiperazine-1-carbaldehyde 0
                                              6,7-dimethoxy-4-\{8-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydroisoquinolin-2-(1H)-yl\}quinazoline 0
                                              6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)ethyl]-9H-purine-2-carbonitrile 0
                                              9-cyclopentyl-6-\{2-[3-(4-methylpiperazin-1-yl)propoxy]phenylamino\}-9H-purine-2-carbonitrile 0
                                              9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid + 210
                                              ASP-3026 0
                                              AZD2858 0
                                              AZD5153 0
                                              BI-4020 0
                                              GSK461364 0
                                              JTE-607 free base 0
                                              LB42908 0
                                              N-(4-\{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl\}-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide 0
                                              N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)-2-(4-methylpiperazin-1-yl)pyridine-4-carboxamide 0
                                              N-[(1S)-3-\{[(benzyloxy)amino]sulfonyl\}-1-(2-phenylethyl)propyl]-N-[(4-methylpiperazin-1-yl)carbonyl]-L-phenylalaninamide 0
                                              N-[(2R,3R,6R)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-2-(2-pyridinyl)acetamide 0
                                              N-[(2R,3R,6S)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-2-(2-pyridinyl)acetamide 0
                                              N-[(2R,3S,6R)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-2-(2-pyridinyl)acetamide 0
                                              N-[(2R,3S,6S)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-2-(2-pyridinyl)acetamide 0
                                              N-[(2S,3R,6R)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-2-(2-pyridinyl)acetamide 0
                                              N-[(2S,3R,6S)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-2-(2-pyridinyl)acetamide 0
                                              N-[(2S,3S,6R)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-2-(2-pyridinyl)acetamide 0
                                              N-[(2S,3S,6S)-2-(hydroxymethyl)-6-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-3,6-dihydro-2H-pyran-3-yl]-2-(2-pyridinyl)acetamide 0
                                              N-[(3E)-5-[(2R)-2-methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3(5H)-ylidene]-4-(4-methylpiperazin-1-yl)benzamide 0
                                              N-[(4-methylpiperazin-1-yl)carbonyl]-L-phenylalanin-(N-\{(1S)-3-phenyl-1-[2-(benzenesulfonyl)ethyl]propyl\})amide 0
                                              N-\{4-[4-(4-methylpiperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-ylsulfanyl]phenyl\}cyclopropanecarboxamide 0
                                              N-\{5-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl\}nicotinamide 0
                                              PA-16-0081C 0
                                              SU11274 0
                                              Thiothixene 0
                                              adavosertib 3
                                              amocarzine 0
                                              bosutinib + 26
                                              clozapine 755
                                              diethylcarbamazine 4
                                              entrectinib 0
                                              flumatinib 0
                                              gilteritinib 0
                                              imatinib + 2
                                              methylpiperazinoforskolin 0
                                              olanzapine 150
                                              perazine + 4
                                              pibenzimol + 6
                                              pipebuzone 0
                                              ponatinib 83
                                              prochlorperazine + 3
                                              rifampicin + 407
                                              saracatinib 11
                                              thiethylperazine + 2
                                              thioproperazine 0
                                              trifluoperazine + 43
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