Septin14 (septin 14) - Rat Genome Database

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Gene: Septin14 (septin 14) Mus musculus
Analyze
Symbol: Septin14
Name: septin 14
RGD ID: 1623158
MGI Page MGI
Description: Predicted to enable GTPase activity and molecular adaptor activity. Involved in neuron migration. Located in several cellular components, including dendrite; perikaryon; and perinuclear region of cytoplasm. Is expressed in cerebral cortex and testis. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human SEPTIN14 (septin 14).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700016K13Rik; Sept; Sept14; septin-14
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395129,760,455 - 129,782,048 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5129,760,455 - 129,785,576 (-)EnsemblGRCm39 Ensembl
GRCm385129,683,391 - 129,704,984 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5129,683,391 - 129,708,512 (-)EnsemblGRCm38mm10GRCm38
MGSCv375130,189,266 - 130,214,386 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365129,998,198 - 130,013,946 (-)NCBIMGSCv36mm8
Celera5126,726,340 - 126,750,968 (-)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map568.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. SEPT14 Is Associated with a Reduced Risk for Parkinson's Disease and Expressed in Human Brain. Rozenkrantz L, etal., J Mol Neurosci. 2016 Jul;59(3):343-50. doi: 10.1007/s12031-016-0738-3. Epub 2016 Apr 26.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:14610273   PMID:16141072   PMID:16141073   PMID:20181826   PMID:21873635   PMID:22575789   PMID:32325033  
PMID:33228246   PMID:35571367   PMID:35700329   PMID:38355793  


Genomics

Comparative Map Data
Septin14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395129,760,455 - 129,782,048 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5129,760,455 - 129,785,576 (-)EnsemblGRCm39 Ensembl
GRCm385129,683,391 - 129,704,984 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5129,683,391 - 129,708,512 (-)EnsemblGRCm38mm10GRCm38
MGSCv375130,189,266 - 130,214,386 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365129,998,198 - 130,013,946 (-)NCBIMGSCv36mm8
Celera5126,726,340 - 126,750,968 (-)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map568.24NCBI
SEPTIN14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38755,793,540 - 55,862,752 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl755,793,540 - 55,862,755 (-)EnsemblGRCh38hg38GRCh38
GRCh37755,861,233 - 55,930,445 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36755,828,731 - 55,897,976 (-)NCBINCBI36Build 36hg18NCBI36
Celera766,914,266 - 66,984,265 (-)NCBICelera
Cytogenetic Map7p11.2NCBI
HuRef755,675,705 - 55,745,405 (-)NCBIHuRef
CHM1_1755,864,224 - 55,933,433 (-)NCBICHM1_1
T2T-CHM13v2.0755,953,761 - 56,022,991 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2755,865,484 - 55,934,729 (-)NCBI
Septin14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,610,600 - 32,641,391 (+)NCBIGRCr8
mRatBN7.21226,975,283 - 27,005,588 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,975,344 - 26,998,299 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1228,110,818 - 28,134,146 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01228,721,368 - 28,744,696 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01227,782,847 - 27,806,175 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01230,600,162 - 30,623,173 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1230,600,957 - 30,621,079 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,537,454 - 32,566,343 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41227,876,195 - 27,894,644 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1228,682,649 - 28,700,497 (+)NCBICelera
Cytogenetic Map12q13NCBI
Septin14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554568,066,832 - 8,103,049 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554568,066,570 - 8,102,318 (-)NCBIChiLan1.0ChiLan1.0
SEPTIN14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2660,635,115 - 60,707,848 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17108,959,841 - 109,032,574 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0756,395,962 - 56,467,826 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1756,823,512 - 56,890,798 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl756,830,212 - 56,890,798 (-)Ensemblpanpan1.1panPan2
SEPTIN14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,103,092 - 25,201,880 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1825,121,175 - 25,202,140 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1824,799,738 - 24,840,011 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01825,579,561 - 25,660,845 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1825,565,895 - 25,660,838 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11825,226,986 - 25,308,190 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01824,739,937 - 24,821,181 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01825,410,330 - 25,491,801 (+)NCBIUU_Cfam_GSD_1.0
Septin14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,995,869 - 126,039,120 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365438,002,291 - 8,033,877 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365437,998,207 - 8,033,877 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SEPTIN14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl316,991,002 - 17,026,949 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1316,988,590 - 17,026,258 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,280,895 - 17,317,491 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SEPTIN14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1212,920,114 - 2,989,257 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041180,133,489 - 180,205,055 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Septin14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247408,085,384 - 8,134,973 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247408,086,964 - 8,138,550 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Septin14
1327 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:287
Count of miRNA genes:167
Interacting mature miRNAs:170
Transcripts:ENSMUST00000042266, ENSMUST00000182381, ENSMUST00000182386
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
13464142Bbaa2a_mB.burgdorferi-associated arthritis 2a (mouse)5128571199130052971Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000042266   ⟹   ENSMUSP00000044272
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5129,760,466 - 129,781,323 (-)Ensembl
GRCm38.p6 Ensembl5129,683,402 - 129,704,259 (-)Ensembl
Ensembl Acc Id: ENSMUST00000182381
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5129,760,455 - 129,770,296 (-)Ensembl
GRCm38.p6 Ensembl5129,683,391 - 129,693,232 (-)Ensembl
Ensembl Acc Id: ENSMUST00000182386   ⟹   ENSMUSP00000138729
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5129,760,503 - 129,785,576 (-)Ensembl
GRCm38.p6 Ensembl5129,683,439 - 129,708,512 (-)Ensembl
RefSeq Acc Id: NM_028826   ⟹   NP_083102
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395129,760,455 - 129,782,048 (-)NCBI
GRCm385129,683,391 - 129,704,984 (-)NCBI
MGSCv375130,189,266 - 130,214,386 (-)RGD
Celera5126,726,340 - 126,750,968 (-)RGD
cM Map5 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_083102 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB24381 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000138729
GenBank Protein Q9DA97 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_083102   ⟸   NM_028826
- UniProtKB: E9QMM2 (UniProtKB/Swiss-Prot),   Q9DA97 (UniProtKB/Swiss-Prot),   S4R2P6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000044272   ⟸   ENSMUST00000042266
Ensembl Acc Id: ENSMUSP00000138729   ⟸   ENSMUST00000182386
Protein Domains
Septin-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9DA97-F1-model_v2 AlphaFold Q9DA97 1-430 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921472 AgrOrtholog
Ensembl Genes ENSMUSG00000034219 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000182386 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro G_SEPTIN_dom UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Septin UniProtKB/Swiss-Prot
KEGG Report mmu:74222 UniProtKB/Swiss-Prot
MGD MGI:1921472 ENTREZGENE
NCBI Gene 74222 ENTREZGENE
PANTHER SEPTIN UniProtKB/Swiss-Prot
Pfam Septin UniProtKB/Swiss-Prot
PhenoGen Septin14 PhenoGen
PIRSF Septin UniProtKB/Swiss-Prot
PROSITE G_SEPTIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt E9QMM2 ENTREZGENE
  Q9DA97 ENTREZGENE
  S4R2P6 ENTREZGENE, UniProtKB/TrEMBL
  SEP14_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary E9QMM2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-27 Septin14  septin 14  Sept14  septin 14  Symbol and/or name change 5135510 APPROVED