Setx (senataxin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Setx (senataxin) Mus musculus
Analyze
Symbol: Setx
Name: senataxin
RGD ID: 1622872
MGI Page MGI
Description: Predicted to enable RNA binding activity; identical protein binding activity; and transcription termination site sequence-specific DNA binding activity. Acts upstream of or within circadian rhythm and termination of RNA polymerase II transcription. Predicted to be located in several cellular components, including growth cone; intercellular bridge; and nuclear lumen. Predicted to be active in nuclear body. Is expressed in cerebral cortex ventricular layer and cortical plate. Used to study amyotrophic lateral sclerosis type 4. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 4 and spinocerebellar ataxia with axonal neuropathy 2. Orthologous to human SETX (senataxin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A; A130090N03; A930037J23Rik; Als4; amyotrophic lateral sclerosis 4 homolog; amyotrophic lateral sclerosis 4 protein homolog; AOA2; AW060766; mKIAA0625; probable helicase senataxin; SCAR1; Sen1; SEN1 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39229,013,600 - 29,072,483 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl229,014,193 - 29,072,483 (+)EnsemblGRCm39 Ensembl
GRCm38229,123,588 - 29,182,471 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl229,124,181 - 29,182,471 (+)EnsemblGRCm38mm10GRCm38
MGSCv37228,980,512 - 29,037,991 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36228,976,093 - 29,004,480 (+)NCBIMGSCv36mm8
Celera228,830,977 - 28,888,543 (+)NCBICelera
Cytogenetic Map2A3- BNCBI
cM Map219.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (ISO,ISS)
chromosome, telomeric region  (IEA)
cytoplasm  (ISO,ISS)
growth cone  (ISO,ISS)
intercellular bridge  (IEA,ISO)
nuclear body  (IBA,IEA,ISO)
nuclear chromosome  (ISO,ISS)
nucleolus  (IEA)
nucleoplasm  (ISO,ISS)
nucleus  (ISO,ISS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14621295  
PMID:14770181   PMID:16141072   PMID:16141073   PMID:17967808   PMID:18799693   PMID:20064376   PMID:21677750   PMID:21873635   PMID:22767893   PMID:23180766   PMID:23593030   PMID:24302573  
PMID:24637776   PMID:24760770   PMID:25822250   PMID:27103069   PMID:27626380   PMID:28378742   PMID:29497044   PMID:29725819   PMID:29878059   PMID:29968717   PMID:30010942   PMID:30778901  
PMID:31162944   PMID:32325033   PMID:32328643   PMID:33337500   PMID:34321999   PMID:35732742   PMID:36542058   PMID:37801077   PMID:38355793  


Genomics

Comparative Map Data
Setx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39229,013,600 - 29,072,483 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl229,014,193 - 29,072,483 (+)EnsemblGRCm39 Ensembl
GRCm38229,123,588 - 29,182,471 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl229,124,181 - 29,182,471 (+)EnsemblGRCm38mm10GRCm38
MGSCv37228,980,512 - 29,037,991 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36228,976,093 - 29,004,480 (+)NCBIMGSCv36mm8
Celera228,830,977 - 28,888,543 (+)NCBICelera
Cytogenetic Map2A3- BNCBI
cM Map219.45NCBI
SETX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389132,261,356 - 132,356,744 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9132,261,356 - 132,354,986 (-)EnsemblGRCh38hg38GRCh38
GRCh379135,136,743 - 135,230,373 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369134,126,648 - 134,220,193 (-)NCBINCBI36Build 36hg18NCBI36
Build 349132,168,836 - 132,259,926NCBI
Celera9105,678,763 - 105,772,221 (-)NCBICelera
Cytogenetic Map9q34.13NCBI
HuRef9104,630,757 - 104,723,804 (-)NCBIHuRef
CHM1_19135,286,879 - 135,380,398 (-)NCBICHM1_1
T2T-CHM13v2.09144,475,833 - 144,571,334 (-)NCBIT2T-CHM13v2.0
Setx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8332,825,771 - 32,878,740 (+)NCBIGRCr8
mRatBN7.2312,428,091 - 12,480,801 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl312,427,635 - 12,480,803 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.037,680,430 - 7,731,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,686,503 - 7,730,539 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0313,029,002 - 13,080,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.438,113,749 - 8,156,463 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera37,210,020 - 7,259,874 (+)NCBICelera
Cytogenetic Map3p12NCBI
Setx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555131,718,377 - 1,777,021 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555131,718,432 - 1,776,133 (-)NCBIChiLan1.0ChiLan1.0
SETX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2116,999,456 - 7,095,610 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan197,000,759 - 7,097,946 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09103,381,356 - 103,474,902 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19132,016,513 - 132,109,665 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9132,016,767 - 132,109,665 (-)Ensemblpanpan1.1panPan2
SETX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1951,900,004 - 51,980,694 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl951,901,233 - 51,978,833 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha951,164,800 - 51,245,022 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0952,793,044 - 52,873,500 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl952,793,516 - 52,871,521 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1951,573,459 - 51,653,339 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0951,897,710 - 51,978,318 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0951,983,718 - 52,064,342 (+)NCBIUU_Cfam_GSD_1.0
Setx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,087,545 - 199,175,658 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648718,855,744 - 18,944,158 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648718,858,384 - 18,945,253 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SETX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1272,095,358 - 272,170,747 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11272,093,449 - 272,170,857 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21306,152,306 - 306,230,231 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SETX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1125,773,122 - 5,872,372 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl125,773,165 - 5,875,481 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660799,727,751 - 9,825,267 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Setx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247603,955,494 - 4,007,610 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247603,932,213 - 4,007,290 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1125
Count of miRNA genes:632
Interacting mature miRNAs:794
Transcripts:ENSMUST00000061578, ENSMUST00000129544, ENSMUST00000135992, ENSMUST00000145422, ENSMUST00000154910
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552706Cia24_mcollagen induced arthritis QTL 24 (mouse)Not determined22467911533523172Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
12904005Cfq2_mconditioned fear QTL 2 (mouse)22702264256396228Mouse
14746979Manh51_mmandible shape 51 (mouse)22896112962961129Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
8552705Cia25_mcollagen induced arthritis 25 (mouse)Not determined22467911533523172Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
14746997Mancz2_mmandible centroid size 2 (mouse)22896112962961129Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse

Markers in Region
AW060766  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38229,182,024 - 29,182,116UniSTSGRCm38
MGSCv37229,037,544 - 29,037,636UniSTSGRCm37
Celera228,888,096 - 28,888,188UniSTS
Cytogenetic Map2A3UniSTS
Whitehead/MRC_RH2473.72UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_198033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030251650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001782867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK038259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL772379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL845267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK001523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000061578   ⟹   ENSMUSP00000051492
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl229,015,004 - 29,072,483 (+)Ensembl
GRCm38.p6 Ensembl229,124,992 - 29,182,471 (+)Ensembl
Ensembl Acc Id: ENSMUST00000129544   ⟹   ENSMUSP00000119521
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl229,014,193 - 29,020,257 (+)Ensembl
GRCm38.p6 Ensembl229,124,181 - 29,130,245 (+)Ensembl
Ensembl Acc Id: ENSMUST00000135992
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl229,047,228 - 29,052,774 (+)Ensembl
GRCm38.p6 Ensembl229,157,216 - 29,162,762 (+)Ensembl
Ensembl Acc Id: ENSMUST00000145422   ⟹   ENSMUSP00000119176
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl229,054,470 - 29,069,552 (+)Ensembl
GRCm38.p6 Ensembl229,164,458 - 29,179,540 (+)Ensembl
Ensembl Acc Id: ENSMUST00000154910
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl229,015,898 - 29,020,461 (+)Ensembl
GRCm38.p6 Ensembl229,125,886 - 29,130,449 (+)Ensembl
RefSeq Acc Id: NM_198033   ⟹   NP_932150
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39229,015,004 - 29,072,483 (+)NCBI
GRCm38229,124,992 - 29,182,471 (+)NCBI
MGSCv37228,980,512 - 29,037,991 (+)RGD
Celera228,830,977 - 28,888,543 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006498079   ⟹   XP_006498142
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39229,014,995 - 29,072,483 (+)NCBI
GRCm38229,124,982 - 29,182,471 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006498080   ⟹   XP_006498143
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39229,014,174 - 29,072,483 (+)NCBI
GRCm38229,124,162 - 29,182,340 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006498082   ⟹   XP_006498145
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39229,015,179 - 29,072,483 (+)NCBI
GRCm38229,125,029 - 29,182,340 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030251650   ⟹   XP_030107510
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39229,013,600 - 29,072,483 (+)NCBI
GRCm38229,123,588 - 29,182,340 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001782867
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39229,015,181 - 29,072,483 (+)NCBI
GRCm38229,124,973 - 29,182,471 (+)NCBI
Sequence:
RefSeq Acc Id: NP_932150   ⟸   NM_198033
- UniProtKB: Q8C859 (UniProtKB/Swiss-Prot),   Q8C5P1 (UniProtKB/Swiss-Prot),   Q80V90 (UniProtKB/Swiss-Prot),   Q6ZQ81 (UniProtKB/Swiss-Prot),   Q6PED8 (UniProtKB/Swiss-Prot),   Q6IMG6 (UniProtKB/Swiss-Prot),   A2AR33 (UniProtKB/Swiss-Prot),   A2AKX4 (UniProtKB/Swiss-Prot),   Q8C8P6 (UniProtKB/Swiss-Prot),   A2AKX3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006498143   ⟸   XM_006498080
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006498142   ⟸   XM_006498079
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006498145   ⟸   XM_006498082
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030107510   ⟸   XM_030251650
- Peptide Label: isoform X1
Ensembl Acc Id: ENSMUSP00000119176   ⟸   ENSMUST00000145422
Ensembl Acc Id: ENSMUSP00000051492   ⟸   ENSMUST00000061578
Ensembl Acc Id: ENSMUSP00000119521   ⟸   ENSMUST00000129544
Protein Domains
DNA2/NAM7 helicase helicase   DNA2/NAM7 helicase-like C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A2AKX3-F1-model_v2 AlphaFold A2AKX3 1-2646 view protein structure

Promoters
RGD ID:6832683
Promoter ID:MM_KWN:28433
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_198033,   OTTMUST00000027769,   UC008IZL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36228,979,991 - 28,981,192 (+)MPROMDB
RGD ID:6876822
Promoter ID:EPDNEW_M1862
Type:initiation region
Name:Setx_1
Description:Mus musculus senataxin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1863  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38229,124,995 - 29,125,055EPDNEW
RGD ID:6876824
Promoter ID:EPDNEW_M1863
Type:multiple initiation site
Name:Setx_2
Description:Mus musculus senataxin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1862  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38229,125,156 - 29,125,216EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2443480 AgrOrtholog
Ensembl Genes ENSMUSG00000043535 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000061578 ENTREZGENE
  ENSMUST00000061578.9 UniProtKB/Swiss-Prot
  ENSMUST00000129544.8 UniProtKB/TrEMBL
  ENSMUST00000145422.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DNA2/NAM7-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA2/NAM7-like_AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA2/NAM7_AAA_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SF1_C_Upf1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:269254 UniProtKB/Swiss-Prot
MGD MGI:2443480 ENTREZGENE
NCBI Gene 269254 ENTREZGENE
PANTHER HELICASE SENATAXIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10887 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Setx PhenoGen
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MQJ0_MOUSE UniProtKB/TrEMBL
  A2AKX3 ENTREZGENE
  A2AKX4 ENTREZGENE
  A2AR33 ENTREZGENE
  F6R186_MOUSE UniProtKB/TrEMBL
  Q6IMG6 ENTREZGENE
  Q6PED8 ENTREZGENE
  Q6ZQ81 ENTREZGENE
  Q80V90 ENTREZGENE
  Q8C5P1 ENTREZGENE
  Q8C859 ENTREZGENE
  Q8C8P6 ENTREZGENE
  SETX_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A2AKX4 UniProtKB/Swiss-Prot
  A2AR33 UniProtKB/Swiss-Prot
  Q6IMG6 UniProtKB/Swiss-Prot
  Q6PED8 UniProtKB/Swiss-Prot
  Q6ZQ81 UniProtKB/Swiss-Prot
  Q80V90 UniProtKB/Swiss-Prot
  Q8C5P1 UniProtKB/Swiss-Prot
  Q8C859 UniProtKB/Swiss-Prot
  Q8C8P6 UniProtKB/Swiss-Prot