Mat2a (methionine adenosyltransferase 2A) - Rat Genome Database

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Gene: Mat2a (methionine adenosyltransferase 2A) Mus musculus
Analyze
Symbol: Mat2a
Name: methionine adenosyltransferase 2A
RGD ID: 732781
MGI Page MGI
Description: Enables methionine adenosyltransferase activity. Acts upstream of or within S-adenosylmethionine biosynthetic process and cellular response to leukemia inhibitory factor. Predicted to be part of methionine adenosyltransferase complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; eye; liver and biliary system; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human MAT2A (methionine adenosyltransferase 2A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adoMet synthase 2; adoMet synthetase 2; D630045P18Rik; MAT 2; methionine adenosyltransferase 2; methionine adenosyltransferase II, alpha; MGC6545; S-adenosylmethionine synthase isoform type-2; S-adenosylmethionine synthetase isoform type-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm9523  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,409,779 - 72,416,539 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl672,409,782 - 72,416,541 (-)EnsemblGRCm39 Ensembl
GRCm38672,432,796 - 72,439,556 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,432,799 - 72,439,558 (-)EnsemblGRCm38mm10GRCm38
MGSCv37672,382,793 - 72,389,552 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36672,362,308 - 72,369,067 (-)NCBIMGSCv36mm8
Celera674,527,849 - 74,534,608 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (EXP)
4-phenylbutyric acid  (ISO)
5-formyltetrahydrofolic acid  (ISO)
7,12-dimethyltetraphene  (EXP)
acetaldehyde  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
cannabidiol  (EXP,ISO)
carbon nanotube  (EXP)
chloropicrin  (ISO)
chloroprene  (EXP,ISO)
choline  (EXP)
chrysene  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crotonaldehyde  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
ferric oxide  (EXP)
fipronil  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (ISO)
gentamycin  (ISO)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (EXP)
ivermectin  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
MeIQx  (ISO)
menadione  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naphthalenes  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
Nutlin-3  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercitrin  (ISO)
quinomethionate  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-adenosyl-L-methioninate  (EXP)
S-adenosyl-L-methionine  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
streptozocin  (EXP)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
trichloroethene  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
WIN 55212-2  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development. Chen YW, etal., J Immunol Res. 2021 Jun 24;2021:5510869. doi: 10.1155/2021/5510869. eCollection 2021.
2. S-adenosylmethionine in liver health, injury, and cancer. Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain. Ngai YF, etal., Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R613-22. doi: 10.1152/ajpregu.00075.2015. Epub 2015 Jul 15.
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10512203   PMID:10644686   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12023972   PMID:12477932   PMID:12520002   PMID:12904583  
PMID:14610273   PMID:15226823   PMID:15741177   PMID:15782199   PMID:15840001   PMID:16141072   PMID:16141073   PMID:17631143   PMID:19158324   PMID:20043323   PMID:20439489   PMID:21362551  
PMID:21873635   PMID:21909369   PMID:23539621   PMID:24194600   PMID:25925782   PMID:26166573   PMID:27626380   PMID:28378742   PMID:29021282   PMID:29749642   PMID:30196744   PMID:30265288  
PMID:30333137   PMID:30457570   PMID:30753104   PMID:31162944   PMID:31234428   PMID:32325033   PMID:32554809   PMID:34359856   PMID:34702858   PMID:35064691   PMID:35422502   PMID:35729157  
PMID:36975381   PMID:38355793  


Genomics

Comparative Map Data
Mat2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,409,779 - 72,416,539 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl672,409,782 - 72,416,541 (-)EnsemblGRCm39 Ensembl
GRCm38672,432,796 - 72,439,556 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,432,799 - 72,439,558 (-)EnsemblGRCm38mm10GRCm38
MGSCv37672,382,793 - 72,389,552 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36672,362,308 - 72,369,067 (-)NCBIMGSCv36mm8
Celera674,527,849 - 74,534,608 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.27NCBI
MAT2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38285,539,168 - 85,545,281 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl285,539,168 - 85,545,281 (+)EnsemblGRCh38hg38GRCh38
GRCh37285,766,291 - 85,772,404 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,619,799 - 85,625,914 (+)NCBINCBI36Build 36hg18NCBI36
Build 34285,677,945 - 85,684,059NCBI
Celera285,594,476 - 85,600,591 (+)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef285,662,610 - 85,669,745 (+)NCBIHuRef
CHM1_1285,695,908 - 85,702,210 (+)NCBICHM1_1
T2T-CHM13v2.0285,541,227 - 85,547,340 (+)NCBIT2T-CHM13v2.0
Mat2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,048,043 - 106,053,612 (-)NCBIGRCr8
mRatBN7.24104,489,877 - 104,495,447 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,488,466 - 104,495,493 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4109,869,381 - 109,874,948 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,644,494 - 105,650,061 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,257,643 - 104,263,213 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,297,478 - 100,303,047 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,296,075 - 100,303,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04165,067,990 - 165,073,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44105,739,943 - 105,745,472 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14105,984,423 - 105,989,953 (-)NCBI
Celera493,642,240 - 93,647,807 (-)NCBICelera
Cytogenetic Map4q32NCBI
Mat2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554241,953,623 - 1,961,164 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554241,953,623 - 1,961,164 (-)NCBIChiLan1.0ChiLan1.0
MAT2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21240,837,386 - 40,847,214 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A40,840,148 - 40,849,976 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A85,589,301 - 85,595,437 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A87,140,504 - 87,148,322 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A87,141,857 - 87,148,322 (+)Ensemblpanpan1.1panPan2
MAT2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11739,525,635 - 39,532,512 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1739,525,626 - 39,532,512 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1739,197,011 - 39,203,887 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01740,272,327 - 40,279,204 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1740,272,327 - 40,279,221 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11739,401,948 - 39,408,822 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01739,473,851 - 39,480,724 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01739,873,693 - 39,880,568 (-)NCBIUU_Cfam_GSD_1.0
Mat2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629279,141,369 - 79,147,930 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367121,709,716 - 1,717,499 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367121,710,513 - 1,717,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAT2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl359,218,688 - 59,225,249 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1359,220,203 - 59,225,097 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2362,132,444 - 62,137,337 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAT2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,609,533 - 21,615,822 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1421,611,040 - 21,615,615 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604590,847,836 - 90,855,647 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mat2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474917,596,381 - 17,603,867 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474917,596,381 - 17,603,804 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1211
Count of miRNA genes:561
Interacting mature miRNAs:692
Transcripts:ENSMUST00000059472
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64209335876093500Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671958006105958152Mouse
12910785Pwgrq16_mpost-weaning growth rate QTL 16 (mouse)64380374777788506Mouse
4140983Srilp_msleep response to influenza, light phase (mouse)Not determined4870349075424693Mouse
12910798Pwgrq5_mpre-weaning growth rate QTL 5 (mouse)64380374777788506Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
12910807Pwbwq11_mpost-weaning body weight QTL 11 (mouse)64380374777788506Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65115613485156284Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671552042105552160Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67129960593441074Mouse
12910802Pwbwq12_mpost-weaning body weight QTL 12 (mouse)64380374777788506Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64529099387403016Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7129960586252701Mouse
12910809Pwbwq10_mpost-weaning body weight QTL 10 (mouse)64380374777788506Mouse
12910820Ogrq3_moverall growth rate QTL 3 (mouse)64380374777788506Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670402880104403016Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666690851100691013Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670402880104403016Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671958006105958152Mouse
10412119Stv_mstriatal volumne (mouse)Not determined660026991100026967Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65842456692424693Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5435041188356155Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65851741692517416Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670402880104403016Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
15039373Adip28_madiposity 28 (mouse)65628519490285194Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66346172197461888Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65628519490285194Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64157698575576985Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64209335876093500Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64209335876093500Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64209335876093500Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66003466394034782Mouse

Markers in Region
AI449819  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38672,440,362 - 72,440,479UniSTSGRCm38
MGSCv37672,390,356 - 72,390,473UniSTSGRCm37
Celera674,535,412 - 74,535,529UniSTS
Cytogenetic Map6C1UniSTS
Whitehead/MRC_RH6721.28UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001363798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB070266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC116115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000059472   ⟹   ENSMUSP00000087118
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl672,409,782 - 72,416,541 (-)Ensembl
GRCm38.p6 Ensembl672,432,799 - 72,439,558 (-)Ensembl
Ensembl Acc Id: ENSMUST00000205335   ⟹   ENSMUSP00000145696
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl672,409,782 - 72,416,539 (-)Ensembl
GRCm38.p6 Ensembl672,432,799 - 72,439,556 (-)Ensembl
Ensembl Acc Id: ENSMUST00000205384   ⟹   ENSMUSP00000146301
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl672,412,794 - 72,416,371 (-)Ensembl
GRCm38.p6 Ensembl672,435,811 - 72,439,388 (-)Ensembl
Ensembl Acc Id: ENSMUST00000205823   ⟹   ENSMUSP00000145983
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl672,409,783 - 72,411,974 (-)Ensembl
GRCm38.p6 Ensembl672,432,800 - 72,434,991 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206368
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl672,413,400 - 72,416,523 (-)Ensembl
GRCm38.p6 Ensembl672,436,417 - 72,439,540 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206692   ⟹   ENSMUSP00000145603
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl672,411,528 - 72,416,539 (-)Ensembl
GRCm38.p6 Ensembl672,434,545 - 72,439,556 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206783
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl672,415,785 - 72,416,539 (-)Ensembl
GRCm38.p6 Ensembl672,438,802 - 72,439,556 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206900
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl672,414,383 - 72,416,531 (-)Ensembl
GRCm38.p6 Ensembl672,437,400 - 72,439,548 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206904   ⟹   ENSMUSP00000146319
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl672,410,883 - 72,412,059 (-)Ensembl
GRCm38.p6 Ensembl672,433,900 - 72,435,076 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206962
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl672,413,731 - 72,416,526 (-)Ensembl
GRCm38.p6 Ensembl672,436,748 - 72,439,543 (-)Ensembl
RefSeq Acc Id: NM_001363798   ⟹   NP_001350727
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,409,779 - 72,416,539 (-)NCBI
GRCm38672,432,796 - 72,439,556 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001363799   ⟹   NP_001350728
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,409,779 - 72,416,539 (-)NCBI
GRCm38672,432,796 - 72,439,556 (-)NCBI
Sequence:
RefSeq Acc Id: NM_145569   ⟹   NP_663544
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,409,779 - 72,416,539 (-)NCBI
GRCm38672,432,796 - 72,439,556 (-)NCBI
MGSCv37672,382,793 - 72,389,552 (-)RGD
Celera674,527,849 - 74,534,608 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_663544   ⟸   NM_145569
- Peptide Label: isoform 1
- UniProtKB: Q3TL60 (UniProtKB/Swiss-Prot),   Q76LX3 (UniProtKB/Swiss-Prot),   Q3THS6 (UniProtKB/Swiss-Prot),   Q99J57 (UniProtKB/TrEMBL),   Q3TED1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001350728   ⟸   NM_001363799
- Peptide Label: isoform 3
- UniProtKB: A0A0U1RNK6 (UniProtKB/TrEMBL),   Q3UZA2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001350727   ⟸   NM_001363798
- Peptide Label: isoform 2
- UniProtKB: A0A0U1RNT6 (UniProtKB/TrEMBL),   Q3TSS0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000087118   ⟸   ENSMUST00000059472
Ensembl Acc Id: ENSMUSP00000145603   ⟸   ENSMUST00000206692
Ensembl Acc Id: ENSMUSP00000146319   ⟸   ENSMUST00000206904
Ensembl Acc Id: ENSMUSP00000145983   ⟸   ENSMUST00000205823
Ensembl Acc Id: ENSMUSP00000146301   ⟸   ENSMUST00000205384
Ensembl Acc Id: ENSMUSP00000145696   ⟸   ENSMUST00000205335
Protein Domains
S-adenosylmethionine synthetase C-terminal   S-adenosylmethionine synthetase central   S-adenosylmethionine synthetase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3THS6-F1-model_v2 AlphaFold Q3THS6 1-395 view protein structure

Promoters
RGD ID:6848842
Promoter ID:MM_TRO:8287
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   MEF_B6
Transcripts:MTR004108.6.1320.4
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36672,383,906 - 72,385,137 (-)MPROMDB
RGD ID:6848010
Promoter ID:MM_ACW:41602
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:MAT2A.FSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36672,386,381 - 72,386,881 (-)MPROMDB
RGD ID:6839606
Promoter ID:MM_KWN:46466
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000066627,   NM_145569,   UC009CIQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36672,389,179 - 72,389,679 (-)MPROMDB
RGD ID:6890020
Promoter ID:EPDNEW_M8461
Type:multiple initiation site
Name:Mat2a_1
Description:Mus musculus methionine adenosyltransferase II, alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38672,439,556 - 72,439,616EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2443731 AgrOrtholog
Ensembl Genes ENSMUSG00000053907 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000059472 ENTREZGENE
  ENSMUST00000059472.10 UniProtKB/Swiss-Prot
  ENSMUST00000205335 ENTREZGENE
  ENSMUST00000205335.2 UniProtKB/TrEMBL
  ENSMUST00000205384.2 UniProtKB/TrEMBL
  ENSMUST00000205823.2 UniProtKB/TrEMBL
  ENSMUST00000206692 ENTREZGENE
  ENSMUST00000206692.2 UniProtKB/TrEMBL
  ENSMUST00000206904.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.300.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADOMET_SYNTHASE_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synt_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synt_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synthetase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synthetase_sfam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:232087 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2443731 ENTREZGENE
NCBI Gene 232087 ENTREZGENE
PANTHER PTHR11964 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam S-AdoMet_synt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synt_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synt_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mat2a PhenoGen
PIRSF MAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADOMET_SYNTHASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADOMET_SYNTHASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55973 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RNK6 ENTREZGENE, UniProtKB/TrEMBL
  A0A0U1RNT6 ENTREZGENE, UniProtKB/TrEMBL
  A0A0U1RPH4_MOUSE UniProtKB/TrEMBL
  A0A0U1RQ95_MOUSE UniProtKB/TrEMBL
  A0A0U1RQB0_MOUSE UniProtKB/TrEMBL
  METK2_MOUSE UniProtKB/Swiss-Prot
  Q3TED1 ENTREZGENE, UniProtKB/TrEMBL
  Q3THS6 ENTREZGENE
  Q3TL60 ENTREZGENE
  Q3TSS0 ENTREZGENE, UniProtKB/TrEMBL
  Q3UAP7_MOUSE UniProtKB/TrEMBL
  Q3UZA2 ENTREZGENE, UniProtKB/TrEMBL
  Q6PE05_MOUSE UniProtKB/TrEMBL
  Q76LX3 ENTREZGENE
  Q99J57 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q3TL60 UniProtKB/Swiss-Prot
  Q76LX3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Mat2a  methionine adenosyltransferase 2A  Mat2a  methionine adenosyltransferase II, alpha  Symbol and/or name change 5135510 APPROVED