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Gene: Mat2a (methionine adenosyltransferase II, alpha) Mus musculus
Symbol: Mat2a
Name: methionine adenosyltransferase II, alpha
Description: Exhibits methionine adenosyltransferase activity. Involved in S-adenosylmethionine biosynthetic process and cellular response to leukemia inhibitory factor. Predicted to localize to cytosol and methionine adenosyltransferase complex. Is expressed in eye; gut; male reproductive gland or organ; metanephros; and nervous system. Orthologous to human MAT2A (methionine adenosyltransferase 2A); PARTICIPATES IN choline metabolic pathway; glycine N-methyltransferase deficiency pathway; homocystinuria pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,5-diethoxycarbonyl-1,4-dihydrocollidine; 7,12-dimethyltetraphene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adoMet synthase 2; adoMet synthetase 2; D630045P18Rik; MAT 2; methionine adenosyltransferase 2; MGC6545; S-adenosylmethionine synthase isoform type-2; S-adenosylmethionine synthetase isoform type-2
Homo sapiens (human) : MAT2A (methionine adenosyltransferase 2A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mat2a (methionine adenosyltransferase 2A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mat2a (methionine adenosyltransferase 2A)
Pan paniscus (bonobo/pygmy chimpanzee) : MAT2A (methionine adenosyltransferase 2A)
Canis lupus familiaris (dog) : MAT2A (methionine adenosyltransferase 2A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mat2a (methionine adenosyltransferase 2A)
Sus scrofa (pig) : MAT2A (methionine adenosyltransferase 2A)
Chlorocebus sabaeus (African green monkey) : MAT2A (methionine adenosyltransferase 2A)
Heterocephalus glaber (naked mole-rat) : Mat2a (methionine adenosyltransferase 2A)
more info ...
Related Pseudogenes: Gm9523  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl672,432,799 - 72,439,558 (-)EnsemblGRCm38mm10GRCm38
GRCm38672,432,796 - 72,439,556 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37672,382,793 - 72,389,552 (-)NCBIGRCm37mm9NCBIm37
MGSCv36672,362,308 - 72,369,067 (-)NCBImm8
Celera674,527,849 - 74,534,608 (-)NCBICelera
Cytogenetic Map6C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Mat2a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732781
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.