Pank3 (pantothenate kinase 3) - Rat Genome Database

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Gene: Pank3 (pantothenate kinase 3) Mus musculus
Analyze
Symbol: Pank3
Name: pantothenate kinase 3
RGD ID: 1321489
MGI Page MGI
Description: Enables pantothenate kinase activity. Acts upstream of or within coenzyme A biosynthetic process. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PANK3 (pantothenate kinase 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC38148; mPanK3; pantothenic acid kinase 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,660,322 - 35,682,112 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,660,311 - 35,682,112 (+)EnsemblGRCm39 Ensembl
GRCm381135,769,495 - 35,791,285 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,769,484 - 35,791,285 (+)EnsemblGRCm38mm10GRCm38
MGSCv371135,582,997 - 35,604,787 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361135,612,907 - 35,629,937 (+)NCBIMGSCv36mm8
Celera1139,552,538 - 39,574,327 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1121.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IDA)
cytosol  (IBA,ISO)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome. Zhou B, etal., Nat Genet 2001 Aug;28(4):345-9.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273  
PMID:14681479   PMID:15226823   PMID:15489334   PMID:16040613   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17379144   PMID:18799693   PMID:21873635   PMID:22815849   PMID:23152917  
PMID:24194600   PMID:25195535   PMID:27149259  


Genomics

Comparative Map Data
Pank3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,660,322 - 35,682,112 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,660,311 - 35,682,112 (+)EnsemblGRCm39 Ensembl
GRCm381135,769,495 - 35,791,285 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,769,484 - 35,791,285 (+)EnsemblGRCm38mm10GRCm38
MGSCv371135,582,997 - 35,604,787 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361135,612,907 - 35,629,937 (+)NCBIMGSCv36mm8
Celera1139,552,538 - 39,574,327 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1121.96NCBI
PANK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385168,548,495 - 168,579,368 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5168,548,495 - 168,579,368 (-)EnsemblGRCh38hg38GRCh38
GRCh375167,975,500 - 168,006,373 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365167,915,208 - 167,939,166 (-)NCBINCBI36Build 36hg18NCBI36
Build 345167,915,207 - 167,939,166NCBI
Celera5164,017,978 - 164,041,945 (-)NCBICelera
Cytogenetic Map5q34NCBI
HuRef5163,081,076 - 163,105,105 (-)NCBIHuRef
CHM1_15167,415,556 - 167,439,549 (-)NCBICHM1_1
T2T-CHM13v2.05169,083,277 - 169,114,160 (-)NCBIT2T-CHM13v2.0
Pank3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81020,733,191 - 20,757,017 (+)NCBIGRCr8
mRatBN7.21020,229,129 - 20,252,955 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1020,229,129 - 20,252,955 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1024,979,846 - 25,004,093 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01024,468,370 - 24,492,618 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01019,952,903 - 19,976,746 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01020,591,432 - 20,615,258 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1020,591,432 - 20,615,258 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01020,465,068 - 20,488,894 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41020,679,354 - 20,699,173 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11020,680,400 - 20,699,788 (+)NCBI
Celera1019,848,167 - 19,871,989 (+)NCBICelera
Cytogenetic Map10q12NCBI
Pank3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540821,630,849 - 21,652,999 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540821,630,849 - 21,643,432 (-)NCBIChiLan1.0ChiLan1.0
PANK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24163,711,302 - 163,742,205 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15161,850,847 - 161,881,956 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05163,913,842 - 163,944,939 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15170,685,413 - 170,709,211 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5170,685,413 - 170,709,211 (-)Ensemblpanpan1.1panPan2
PANK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1443,168,407 - 43,192,451 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl443,137,709 - 43,186,022 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha443,124,952 - 43,148,972 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0443,590,196 - 43,614,178 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl443,559,492 - 43,614,148 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1443,360,020 - 43,383,978 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0443,554,528 - 43,578,544 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0444,060,307 - 44,084,283 (+)NCBIUU_Cfam_GSD_1.0
Pank3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721397,194,374 - 97,219,607 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936622809,880 - 828,849 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936622810,016 - 836,103 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PANK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1655,313,324 - 55,340,065 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11655,313,333 - 55,340,070 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21659,896,478 - 59,917,704 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PANK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12370,784,208 - 70,809,012 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2370,785,078 - 70,808,932 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660347,871,157 - 7,918,293 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pank3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473321,382,414 - 21,400,396 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473321,382,404 - 21,401,815 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pank3
854 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1794
Count of miRNA genes:718
Interacting mature miRNAs:972
Transcripts:ENSMUST00000018990
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1300990Bits3_mbitterness sensitivity 3 (mouse)Not determined11837212142372260Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
10412216Eae44_mexperimental allergic encephalomyelitis susceptibility 44 (mouse)Not determined111226863739950840Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
1301814Bbaa7_mB.burgdorferi-associated arthritis 7 (mouse)Not determined112601178044264695Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112719805750636094Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112719805750636094Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112719805750636094Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112719805750636094Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112719805750636094Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
10043922Alcw9_malcohol withdrawal 9 (mouse)Not determined113557861644065931Mouse
1301718Pbw3_mpentobarbital withdrawal QTL 3 (mouse)Not determined113557861644065931Mouse
1558769Zolw1_mzolpidem withdrawal 1 (mouse)Not determined113557861644065931Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse

Markers in Region
Pank3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A4UniSTS
cM Map1121.96UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000018990   ⟹   ENSMUSP00000018990
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,660,311 - 35,682,112 (+)Ensembl
GRCm38.p6 Ensembl1135,769,484 - 35,791,285 (+)Ensembl
RefSeq Acc Id: NM_145962   ⟹   NP_666074
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391135,660,322 - 35,682,112 (+)NCBI
GRCm381135,769,495 - 35,791,285 (+)ENTREZGENE
MGSCv371135,582,997 - 35,604,787 (+)RGD
Celera1139,552,538 - 39,574,327 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_666074   ⟸   NM_145962
- UniProtKB: Q8R2W9 (UniProtKB/Swiss-Prot),   Q5SXA7 (UniProtKB/TrEMBL),   Q7M752 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000018990   ⟸   ENSMUST00000018990

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R2W9-F1-model_v2 AlphaFold Q8R2W9 1-370 view protein structure

Promoters
RGD ID:6821497
Promoter ID:MM_KWN:6950
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000018990
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361135,582,246 - 35,583,467 (+)MPROMDB
RGD ID:8674296
Promoter ID:EPDNEW_M15178
Type:multiple initiation site
Name:Pank3_1
Description:Mus musculus pantothenate kinase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15179  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381135,769,592 - 35,769,652EPDNEW
RGD ID:8674298
Promoter ID:EPDNEW_M15179
Type:initiation region
Name:Pank3_2
Description:Mus musculus pantothenate kinase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15178  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381135,769,856 - 35,769,916EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2387464 AgrOrtholog
Ensembl Genes ENSMUSG00000018846 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000018990 ENTREZGENE
  ENSMUST00000018990.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.510 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type_II_PanK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:211347 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2387464 ENTREZGENE
NCBI Gene 211347 ENTREZGENE
PANTHER PANTOTHENATE KINASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12280 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Fumble UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pank3 PhenoGen
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt PANK3_MOUSE UniProtKB/Swiss-Prot
  Q3TQQ7_MOUSE UniProtKB/TrEMBL
  Q3UWJ1_MOUSE UniProtKB/TrEMBL
  Q5SXA7 ENTREZGENE, UniProtKB/TrEMBL
  Q7M752 ENTREZGENE, UniProtKB/TrEMBL
  Q8R2W9 ENTREZGENE