Il2ra (interleukin 2 receptor, alpha chain) - Rat Genome Database

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Gene: Il2ra (interleukin 2 receptor, alpha chain) Mus musculus
Analyze
Symbol: Il2ra
Name: interleukin 2 receptor, alpha chain
RGD ID: 735948
MGI Page MGI
Description: Enables interleukin-2 binding activity and interleukin-2 receptor activity. Acts upstream of or within several processes, including Notch signaling pathway; activation-induced cell death of T cells; and regulation of T cell proliferation. Located in external side of plasma membrane. Is expressed in bone marrow. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD25; I; IL-2 receptor subunit alpha; IL-2-RA; IL-2R alpha chain; IL-2R subunit alpha; IL2-RA; Il2r; interleukin-2 receptor subunit alpha; Ly-4; Ly-43; MGC130561; p55 chain
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39211,647,603 - 11,698,005 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl211,647,618 - 11,698,004 (+)EnsemblGRCm39 Ensembl
GRCm38211,642,792 - 11,693,194 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl211,642,807 - 11,693,193 (+)EnsemblGRCm38mm10GRCm38
MGSCv37211,564,419 - 11,614,821 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36211,560,703 - 11,611,044 (+)NCBIMGSCv36mm8
Celera211,560,200 - 11,610,847 (+)NCBICelera
Cytogenetic Map2A1NCBI
cM Map28.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-alpha-phellandrene  (ISO)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthaleneacetic acid  (EXP)
1-nitropropane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-D  (EXP)
2,4-diaminotoluene  (ISO)
2,6-diaminotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-nitro-p-phenylenediamine  (ISO)
2-nitropropane  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-acetylaminofluorene  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
alpha-hexylcinnamaldehyde  (EXP)
alpha-phellandrene  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asbestos  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP)
bathocuproine disulfonic acid  (EXP)
beclomethasone  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
bucladesine  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
capsiate  (ISO)
carbon nanotube  (EXP,ISO)
CGP 52608  (ISO)
clobetasol  (EXP)
clozapine  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dichloroacetic acid  (ISO)
erlotinib hydrochloride  (EXP)
ethanol  (EXP)
flavonoids  (ISO)
folic acid  (ISO)
fragrance  (ISO)
gentamycin  (ISO)
hexachlorobenzene  (ISO)
indole-3-acetic acid  (EXP)
ionomycin  (EXP,ISO)
isopentenyl diphosphate  (ISO)
lactacystin  (EXP)
lipopolysaccharide  (EXP)
mercury dichloride  (EXP)
mesalamine  (ISO)
methotrexate  (ISO)
N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP)
nickel atom  (ISO)
nonanoic acid  (EXP)
o-anisidine  (ISO)
ouabain  (ISO)
paracetamol  (EXP)
PCB138  (EXP)
Pentoxifylline  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalaldehyde  (EXP)
pimecrolimus  (ISO)
procyanidin B3  (EXP)
propofol  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
prostratin  (ISO)
resveratrol  (EXP)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulfasalazine  (ISO)
tacrolimus hydrate  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (ISO)
thiopental  (ISO)
toluene 2,4-diisocyanate  (EXP)
Tributyltin oxide  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
tungsten  (EXP)
valproic acid  (EXP,ISO)
WR-1065  (ISO)
zalcitabine  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell physiology  (IAGP)
abnormal cholesterol homeostasis  (IEA)
abnormal colon morphology  (IEA)
abnormal contextual conditioning behavior  (IEA)
abnormal duodenum morphology  (IEA)
abnormal freezing behavior  (IEA)
abnormal induced morbidity/mortality  (IAGP)
abnormal locomotor behavior  (IEA)
abnormal lymph organ size  (IAGP)
abnormal regulatory T cell physiology  (IAGP)
abnormal salivary gland duct morphology  (IAGP)
abnormal salivary gland morphology  (IAGP)
abnormal spleen morphology  (IEA)
abnormal T cell activation  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal vertebrae morphology  (IEA)
anemia  (IAGP)
cachexia  (IAGP)
colitis  (IAGP)
decreased blood urea nitrogen level  (IEA)
decreased body length  (IEA)
decreased body size  (IAGP)
decreased bone mineral density  (IEA)
decreased circulating alkaline phosphatase level  (IEA)
decreased circulating calcium level  (IEA)
decreased circulating cholesterol level  (IEA)
decreased circulating glucose level  (IEA)
decreased circulating HDL cholesterol level  (IEA)
decreased circulating serum albumin level  (IEA)
decreased circulating total protein level  (IEA)
decreased erythrocyte cell number  (IEA)
decreased exploration in new environment  (IEA)
decreased heart weight  (IEA)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IEA)
decreased locomotor activity  (IEA)
decreased lymphocyte cell number  (IEA)
decreased mean corpuscular hemoglobin  (IEA)
decreased mean corpuscular hemoglobin concentration  (IEA)
decreased mean corpuscular volume  (IEA)
decreased regulatory T cell number  (IAGP)
decreased salivation  (IAGP)
decreased vertical activity  (IEA)
diarrhea  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
hemolytic anemia  (IAGP)
improved glucose tolerance  (IEA)
increased activated T cell number  (IAGP)
increased CD4-positive, alpha beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased circulating aspartate transaminase level  (IEA)
increased circulating phosphate level  (IEA)
increased hematopoietic stem cell number  (IAGP)
increased IgA level  (IAGP)
increased IgG level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased IgG2b level  (IAGP)
increased large unstained cell number  (IEA)
increased lymphocyte cell number  (IAGP)
increased memory T cell number  (IAGP)
increased neutrophil cell number  (IEA)
increased regulatory T cell number  (IAGP)
lacrimal gland inflammation  (IAGP)
large intestinal inflammation  (IAGP)
lung inflammation  (IAGP)
lymphoid hyperplasia  (IAGP)
premature death  (IAGP)
prolonged PR interval  (IEA)
salivary gland inflammation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D). Alcina A, etal., PLoS One. 2009;4(1):e4137. Epub 2009 Jan 6.
2. [Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia]. Chen L, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2020 Mar 12;43(3):203-208. doi: 10.3760/cma.j.issn.1001-0939.2020.03.013.
3. Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis. Desai B, etal., Exp Lung Res. 2011 May;37(4):227-38. Epub 2011 Feb 11.
4. Regulatory T cells enhance persistence of the zoonotic pathogen Seoul virus in its reservoir host. Easterbrook JD, etal., Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15502-7. Epub 2007 Sep 18.
5. Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection. Fulton RB, etal., J Immunol. 2010 Aug 15;185(4):2382-92. Epub 2010 Jul 16.
6. Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19. Hou H, etal., Clin Exp Immunol. 2020 Jul;201(1):76-84. doi: 10.1111/cei.13450. Epub 2020 May 15.
7. Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population. Kawasaki E, etal., J Clin Endocrinol Metab. 2009 Mar;94(3):947-52. Epub 2008 Dec 23.
8. CD4+CD25+Foxp3+ regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in mice. Liu F, etal., PLoS One. 2010 Nov 3;5(11):e15404.
9. Correlation Between Relative Nasopharyngeal Virus RNA Load and Lymphocyte Count Disease Severity in Patients with COVID-19. Liu Y, etal., Viral Immunol. 2020 Apr 10. doi: 10.1089/vim.2020.0062.
10. Alleviating allergic airway diseases by means of short-term administration of IL-2 and dexamethasone. Ma J, etal., J Allergy Clin Immunol. 2011 Jun;127(6):1447-56.e6. Epub 2011 Mar 4.
11. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. Maier LM, etal., PLoS Genet. 2009 Jan;5(1):e1000322. Epub 2009 Jan 2.
12. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
13. MGDs mouse GO annotations MGD data from the GO Consortium
14. MGD IEA MGD IEA
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells. Preston JA, etal., Eur Respir J. 2011 Jan;37(1):53-64. Epub 2010 Jun 4.
19. Presence of Activated Airway T Lymphocytes in Human Puumala Hantavirus Disease. Rasmuson J, etal., Chest. 2011 Mar 24.
20. Mouse MP Annotation Import Pipeline RGD automated import pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor. Sharfe N, etal., Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3168-71.
24. Characterization of Multiple Sclerosis candidate gene expression kinetics in rat experimental autoimmune encephalomyelitis. Thessen Hedreul M, etal., J Neuroimmunol. 2009 May 29;210(1-2):30-9. Epub 2009 Mar 9.
25. Prevention of diabetes: effect of mycophenolate mofetil and anti-CD25 on onset of diabetes in the DRBB rat. Ugrasbul F, etal., Pediatr Diabetes. 2008 Dec;9(6):596-601. Epub 2008 May 21.
Additional References at PubMed
PMID:1420317   PMID:1431091   PMID:1586961   PMID:1587308   PMID:1655359   PMID:2265562   PMID:2987826   PMID:3086480   PMID:3107885   PMID:3135330   PMID:3921620   PMID:6206144  
PMID:7477352   PMID:7489734   PMID:7526894   PMID:7568281   PMID:7584142   PMID:7588326   PMID:7621883   PMID:7636184   PMID:7641685   PMID:7688139   PMID:7719026   PMID:7736574  
PMID:7737111   PMID:7738012   PMID:7738013   PMID:7797614   PMID:7909827   PMID:7981152   PMID:8125140   PMID:8262055   PMID:8392875   PMID:8530383   PMID:8547641   PMID:8563178  
PMID:8597644   PMID:8755570   PMID:8769481   PMID:8828582   PMID:8943338   PMID:9103438   PMID:9104808   PMID:9324354   PMID:9360952   PMID:9395528   PMID:9533452   PMID:9551911  
PMID:9620592   PMID:9636694   PMID:9778244   PMID:9892609   PMID:10072077   PMID:10087302   PMID:10098325   PMID:10229817   PMID:10349636   PMID:10415007   PMID:10687308   PMID:10760791  
PMID:10770800   PMID:10780854   PMID:10784587   PMID:10851055   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11238056   PMID:11475331   PMID:11485747   PMID:11809742   PMID:11927910  
PMID:11932925   PMID:11972331   PMID:12065418   PMID:12183685   PMID:12218095   PMID:12231477   PMID:12271139   PMID:12391195   PMID:12466851   PMID:12477932   PMID:12594277   PMID:12702495  
PMID:12867038   PMID:12958152   PMID:14634080   PMID:14660657   PMID:14699080   PMID:14990792   PMID:15034008   PMID:15100267   PMID:15105501   PMID:15240714   PMID:15294943   PMID:15368291  
PMID:15652752   PMID:15665762   PMID:15677327   PMID:15681783   PMID:15728238   PMID:15753203   PMID:15753207   PMID:15753210   PMID:15758078   PMID:15843532   PMID:15843536   PMID:15880066  
PMID:15909309   PMID:15961541   PMID:16034141   PMID:16087671   PMID:16087867   PMID:16120775   PMID:16141072   PMID:16141073   PMID:16227983   PMID:16227984   PMID:16301745   PMID:16517695  
PMID:16525991   PMID:16574670   PMID:16621991   PMID:16621992   PMID:16632602   PMID:16680369   PMID:16709665   PMID:16723705   PMID:16763207   PMID:16778891   PMID:16785514   PMID:16804081  
PMID:16879995   PMID:16906223   PMID:16912202   PMID:16917540   PMID:16973387   PMID:17032240   PMID:17062002   PMID:17082577   PMID:17114466   PMID:17175224   PMID:17182565   PMID:17207605  
PMID:17237369   PMID:17237396   PMID:17312008   PMID:17325053   PMID:17371960   PMID:17374393   PMID:17492805   PMID:17548606   PMID:17559173   PMID:17625108   PMID:17664294   PMID:17848179  
PMID:17878360   PMID:17947703   PMID:18066074   PMID:18190656   PMID:18310063   PMID:18319615   PMID:18354164   PMID:18390713   PMID:18408572   PMID:18467656   PMID:18521187   PMID:18566388  
PMID:18628982   PMID:18641307   PMID:18641329   PMID:18780166   PMID:18789801   PMID:18792410   PMID:18799693   PMID:18855977   PMID:18941182   PMID:18958875   PMID:18990450   PMID:19003932  
PMID:19008373   PMID:19017930   PMID:19077880   PMID:19155973   PMID:19192224   PMID:19251786   PMID:19342638   PMID:19342640   PMID:19448155   PMID:19528538   PMID:19602726   PMID:19666526  
PMID:19723499   PMID:19752032   PMID:19759824   PMID:19770521   PMID:19880450   PMID:19934022   PMID:19966302   PMID:20096607   PMID:20096608   PMID:20133862   PMID:20305583   PMID:20382706  
PMID:20463654   PMID:20483725   PMID:20519649   PMID:20534878   PMID:20547866   PMID:20566743   PMID:20584975   PMID:20826721   PMID:20881183   PMID:21094858   PMID:21151127   PMID:21170379  
PMID:21217760   PMID:21245393   PMID:21265093   PMID:21364747   PMID:21400499   PMID:21419643   PMID:21422251   PMID:21460847   PMID:21508411   PMID:21510876   PMID:21518973   PMID:21521781  
PMID:21590767   PMID:21677750   PMID:21873635   PMID:22057289   PMID:22057872   PMID:22072979   PMID:22125630   PMID:22271576   PMID:22446627   PMID:22464171   PMID:22496155   PMID:22496812  
PMID:22539790   PMID:22564624   PMID:22786774   PMID:22860054   PMID:22888135   PMID:22981535   PMID:23116218   PMID:23248263   PMID:23715742   PMID:23733872   PMID:23876314   PMID:23986597  
PMID:24120360   PMID:24166977   PMID:24244020   PMID:24249704   PMID:24574458   PMID:24586481   PMID:24633065   PMID:24634493   PMID:24651036   PMID:24909888   PMID:25035957   PMID:25063866  
PMID:25133396   PMID:25430770   PMID:25485946   PMID:26114424   PMID:26392556   PMID:26404745   PMID:26410627   PMID:26420375   PMID:26468284   PMID:26494229   PMID:26569069   PMID:26707936  
PMID:26750312   PMID:26950239   PMID:27085137   PMID:27105495   PMID:27147029   PMID:27389192   PMID:27760760   PMID:28035902   PMID:28074895   PMID:28401883   PMID:28410988   PMID:28678791  
PMID:28810531   PMID:28854172   PMID:29078395   PMID:29934134   PMID:30359308   PMID:30380412   PMID:30560927   PMID:30578871   PMID:30833563   PMID:30858199   PMID:31853004   PMID:32376651  
PMID:33319815   PMID:33334814   PMID:33408345   PMID:34022203   PMID:34108258   PMID:35315876   PMID:35398356   PMID:35474218  


Genomics

Comparative Map Data
Il2ra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39211,647,603 - 11,698,005 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl211,647,618 - 11,698,004 (+)EnsemblGRCm39 Ensembl
GRCm38211,642,792 - 11,693,194 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl211,642,807 - 11,693,193 (+)EnsemblGRCm38mm10GRCm38
MGSCv37211,564,419 - 11,614,821 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36211,560,703 - 11,611,044 (+)NCBIMGSCv36mm8
Celera211,560,200 - 11,610,847 (+)NCBICelera
Cytogenetic Map2A1NCBI
cM Map28.91NCBI
IL2RA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38106,010,689 - 6,062,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl106,010,689 - 6,062,370 (-)EnsemblGRCh38hg38GRCh38
GRCh37106,052,652 - 6,104,330 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36106,093,512 - 6,144,278 (-)NCBINCBI36Build 36hg18NCBI36
Build 34106,093,511 - 6,144,278NCBI
Celera105,982,579 - 6,033,743 (-)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef105,979,490 - 6,030,662 (-)NCBIHuRef
CHM1_1106,052,649 - 6,103,793 (-)NCBICHM1_1
T2T-CHM13v2.0106,011,401 - 6,062,560 (-)NCBIT2T-CHM13v2.0
Il2ra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21766,849,974 - 66,898,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,849,974 - 66,898,697 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1770,337,084 - 70,384,350 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01774,165,907 - 74,213,174 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01768,208,899 - 68,256,163 (-)NCBIRnor_WKY
Rnor_6.01770,500,672 - 70,547,929 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1770,499,083 - 70,548,071 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01772,204,467 - 72,250,556 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41778,050,491 - 78,097,802 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11778,061,323 - 78,108,635 (-)NCBI
Celera1766,355,852 - 66,402,955 (-)NCBICelera
RH 3.4 Map17636.4RGD
Cytogenetic Map17q12.2NCBI
Il2ra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542122,641,511 - 22,694,913 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542122,642,004 - 22,694,729 (-)NCBIChiLan1.0ChiLan1.0
IL2RA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1106,037,664 - 6,086,018 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0106,053,549 - 6,103,863 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IL2RA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1229,892,130 - 29,948,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl229,894,125 - 29,944,643 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha226,924,836 - 26,975,354 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0230,275,012 - 30,330,188 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl230,275,175 - 30,327,642 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1227,372,288 - 27,422,786 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,208,376 - 28,259,290 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0228,928,272 - 28,977,130 (+)NCBIUU_Cfam_GSD_1.0
Il2ra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934432,349,142 - 32,390,487 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364848,514,333 - 8,555,392 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL2RA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1064,948,563 - 65,001,142 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11064,948,149 - 65,001,320 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,153,916 - 71,162,729 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL2RA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.196,134,961 - 6,187,731 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl96,141,430 - 6,149,447 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605111,438,032 - 11,490,878 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il2ra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624775924,648 - 942,354 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624775927,337 - 991,062 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
PMC126074P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38211,645,314 - 11,645,600UniSTSGRCm38
MGSCv37211,566,941 - 11,567,227UniSTSGRCm37
Celera211,562,718 - 11,563,004UniSTS
Cytogenetic Map2A2-A3UniSTS
PMC126074P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38211,642,587 - 11,642,948UniSTSGRCm38
MGSCv37211,564,214 - 11,564,575UniSTSGRCm37
Celera211,559,995 - 11,560,356UniSTS
Cytogenetic Map2A2-A3UniSTS
Il2ra  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A2-A3UniSTS
cM Map26.4UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10045633Heal15_mwound healing/regeneration 15 (mouse)Not determined2121989642Mouse
4141836Tgq11_mtriglyceride QTL 11 (mouse)Not determined125324559Mouse
4142333Tgq10_mtriglyceride QTL 10 (mouse)Not determined125324559Mouse
1301838Sluc16_msusceptibility to lung cancer 16 (mouse)Not determined2126529589Mouse
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323494028179150Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
12903993Opfaq1_mopen field activity QTL 1 (mouse)2967669127022642Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1246
Count of miRNA genes:618
Interacting mature miRNAs:773
Transcripts:ENSMUST00000028111, ENSMUST00000150890
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF054581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF243503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL831794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC114437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY200401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ677837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ677838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K02891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M30856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M54934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000028111   ⟹   ENSMUSP00000028111
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl211,647,618 - 11,698,004 (+)Ensembl
GRCm38.p6 Ensembl211,642,807 - 11,693,193 (+)Ensembl
RefSeq Acc Id: ENSMUST00000150890   ⟹   ENSMUSP00000141881
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl211,647,660 - 11,653,579 (+)Ensembl
GRCm38.p6 Ensembl211,642,849 - 11,648,768 (+)Ensembl
RefSeq Acc Id: ENSMUST00000195427
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl211,684,519 - 11,685,020 (+)Ensembl
GRCm38.p6 Ensembl211,679,708 - 11,680,209 (+)Ensembl
RefSeq Acc Id: NM_008367   ⟹   NP_032393
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39211,647,603 - 11,698,005 (+)NCBI
GRCm38211,642,792 - 11,693,194 (+)ENTREZGENE
MGSCv37211,564,419 - 11,614,821 (+)RGD
Celera211,560,200 - 11,610,847 (+)RGD
cM Map2 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032393   ⟸   NM_008367
- Peptide Label: precursor
- UniProtKB: Q61731 (UniProtKB/Swiss-Prot),   P01590 (UniProtKB/Swiss-Prot),   Q544I2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000141881   ⟸   ENSMUST00000150890
RefSeq Acc Id: ENSMUSP00000028111   ⟸   ENSMUST00000028111
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01590-F1-model_v2 AlphaFold P01590 1-268 view protein structure

Promoters
RGD ID:6876350
Promoter ID:EPDNEW_M1626
Type:initiation region
Name:Il2ra_1
Description:Mus musculus interleukin 2 receptor, alpha chain , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38211,642,850 - 11,642,910EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96549 AgrOrtholog
Ensembl Genes ENSMUSG00000026770 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000028111 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000141881.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000028111 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000150890.3 UniProtKB/TrEMBL
InterPro IL-2_rcpt_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96549 ENTREZGENE
NCBI Gene 16184 ENTREZGENE
PANTHER PTHR10573 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il2ra PhenoGen
PROSITE SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt IL2RA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TAS1_MOUSE UniProtKB/TrEMBL
  Q3THW2_MOUSE UniProtKB/TrEMBL
  Q544I2 ENTREZGENE, UniProtKB/TrEMBL
  Q61731 ENTREZGENE
  Q8C2H9_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q61731 UniProtKB/Swiss-Prot