Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Il2ra (interleukin 2 receptor, alpha chain) Mus musculus
Symbol: Il2ra
Name: interleukin 2 receptor, alpha chain
Description: Exhibits interleukin-2 binding activity and interleukin-2 receptor activity. Involved in several processes, including Notch signaling pathway; activation-induced cell death of T cells; and regulation of T cell proliferation. Localizes to the external side of plasma membrane. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in lymphopenia; multiple sclerosis; primary immunodeficiency disease; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Is expressed in bone marrow. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; endocytosis pathway; INTERACTS WITH (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; 1-chloro-2,4-dinitrobenzene; 1-naphthylacetic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD25; IL-2 receptor subunit alpha; IL-2-RA; IL-2R alpha chain; IL-2R subunit alpha; IL2-RA; Il2r; interleukin-2 receptor subunit alpha; Ly-43; MGC130561; p55 chain
Homo sapiens (human) : IL2RA (interleukin 2 receptor subunit alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Il2ra (interleukin 2 receptor subunit alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il2ra (interleukin 2 receptor subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : IL2RA (interleukin 2 receptor subunit alpha)
Canis lupus familiaris (dog) : IL2RA (interleukin 2 receptor subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il2ra (interleukin 2 receptor subunit alpha)
Sus scrofa (pig) : IL2RA (interleukin 2 receptor subunit alpha)
Chlorocebus sabaeus (green monkey) : IL2RA (interleukin 2 receptor subunit alpha)
Heterocephalus glaber (naked mole-rat) : Il2ra (interleukin 2 receptor subunit alpha)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl211,642,807 - 11,693,193 (+)Ensembl
GRCm38211,642,792 - 11,693,194 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37211,564,419 - 11,614,821 (+)NCBIGRCm37mm9NCBIm37
MGSCv36211,560,703 - 11,611,044 (+)NCBImm8
Celera211,560,200 - 11,610,847 (+)NCBICelera
Cytogenetic Map2 A1NCBI
cM Map28.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Il2ra
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735948
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.