Apoa5 (apolipoprotein A-V) - Rat Genome Database

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Gene: Apoa5 (apolipoprotein A-V) Mus musculus
Analyze
Symbol: Apoa5
Name: apolipoprotein A-V
RGD ID: 733458
MGI Page MGI
Description: Predicted to enable several functions, including heparin binding activity; lipase binding activity; and lipoprotein lipase activator activity. Involved in acylglycerol homeostasis. Acts upstream of or within triglyceride metabolic process and triglyceride-rich lipoprotein particle remodeling. Predicted to be located in extracellular space. Predicted to be part of chylomicron; high-density lipoprotein particle; and very-low-density lipoprotein particle. Is expressed in lung. Human ortholog(s) of this gene implicated in cerebral infarction; coronary artery disease; familial hyperlipidemia (multiple); and type 2 diabetes mellitus. Orthologous to human APOA5 (apolipoprotein A5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1300007O05Rik; apo-AV; apoA-V; Apoav; apolipoprotein A5; R; RAP3; regeneration-associated protein 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39946,179,906 - 46,183,219 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl946,179,931 - 46,183,217 (+)EnsemblGRCm39 Ensembl
GRCm38946,268,608 - 46,271,921 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,268,633 - 46,271,919 (+)EnsemblGRCm38mm10GRCm38
MGSCv37946,076,691 - 46,080,002 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36946,019,603 - 46,022,914 (+)NCBIMGSCv36mm8
Celera943,557,616 - 43,560,927 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
Aroclor 1254  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-hexachlorocyclohexane  (EXP)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
C60 fullerene  (ISO)
CGP 52608  (ISO)
clofibrate  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dicrotophos  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
farnesol  (ISO)
flutamide  (ISO)
folic acid  (EXP)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glycidol  (ISO)
graphite  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (EXP)
isoniazide  (ISO)
L-methionine  (EXP)
menadione  (ISO)
metformin  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
O-methyleugenol  (ISO)
oleic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP)
perfluorobutanesulfonic acid  (EXP)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (EXP,ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
propiconazole  (EXP)
quercetin  (ISO)
rotenone  (ISO)
silibinin  (ISO)
sodium arsenite  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
trichloroethene  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Association of APOA5 -1131T>C and S19W gene polymorphisms with both mild hypertriglyceridemia and hyperchylomicronemia in type 2 diabetic patients. Charriere S, etal., Clin Chim Acta. 2008 Aug;394(1-2):99-103. Epub 2008 Apr 27.
3. SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors. Corella D and Ordovas JM, Annu Rev Nutr. 2005;25:341-90.
4. The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides. Dallongeville J, etal., BMC Med Genet. 2008 Sep 12;9:84.
5. T-1131-->C polymorphism within the apolipoprotein AV gene in hypertriglyceridemic individuals. Horinek A, etal., Atherosclerosis. 2003 Apr;167(2):369-70.
6. Apolipoprotein A5 and hypertriglyceridemia in Prague hypertriglyceridemic rats. Kadlecova M, etal., Physiol Res. 2006;55(4):373-9. Epub 2005 Oct 17.
7. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. APOA5 gene polymorphism modulates levels of triglyceride, HDL cholesterol and FERHDL but is not a risk factor for coronary artery disease. Lee KW, etal., Atherosclerosis. 2004 Sep;176(1):165-72.
9. Polymorphism of apolipoprotein A5 is a risk factor for cerebral infarction in type 2 diabetes. Li X, etal., J Huazhong Univ Sci Technolog Med Sci. 2008 Dec;28(6):653-6. Epub 2008 Dec 24.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Pennacchio LA, etal., Science 2001 Oct 5;294(5540):169-73.
16. Thyroid hormone regulates the hypotriglyceridemic gene APOA5. Prieur X, etal., J Biol Chem. 2005 Jul 29;280(30):27533-43. Epub 2005 Jun 7.
17. Postprandial increase of plasma apoAV concentrations in Type 2 diabetic patients. Pruneta-Deloche V, etal., Atherosclerosis. 2005 Aug;181(2):403-5. Epub 2005 Feb 17.
18. Mouse MP Annotation Import Pipeline RGD automated import pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease. Szalai C, etal., Atherosclerosis. 2004 Mar;173(1):109-14.
22. Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration. van der Vliet HN, etal., J Biol Chem 2001 Nov 30;276(48):44512-20.
23. Four pairs of gene-gene interactions associated with increased risk for type 2 diabetes (CDKN2BAS-KCNJ11), obesity (SLC2A9-IGF2BP2, FTO-APOA5), and hypertension (MC4R-IGF2BP2) in Chinese women. Wang MH, etal., Meta Gene. 2014 May 21;2:384-91. doi: 10.1016/j.mgene.2014.04.010. eCollection 2014 Dec.
24. Association of APOA5 c.553G>T polymorphism with type 2 diabetes mellitus in a Chinese population. Zhai G, etal., Clin Chem Lab Med. 2006;44(11):1313-6.
25. [Association of apolipoprotein A5 gene -1131T/C polymorphism with lipid metabolism and insulin resistance in patients with type II diabetes mellitus] Zhai GH, etal., Yi Chuan. 2007 May;29(5):541-6.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12135615   PMID:12477932   PMID:12615678   PMID:12810823   PMID:14974682   PMID:14983036   PMID:15090553   PMID:15117734   PMID:15131258  
PMID:15306172   PMID:15489334   PMID:15774484   PMID:15790933   PMID:16141072   PMID:16141073   PMID:16166565   PMID:16325772   PMID:16448983   PMID:16498401   PMID:17222847   PMID:17438339  
PMID:17916774   PMID:18056685   PMID:18243209   PMID:18572192   PMID:18678879   PMID:19141870   PMID:19362162   PMID:19825998   PMID:20153840   PMID:20562862   PMID:20966404   PMID:21258337  
PMID:21267068   PMID:21873635   PMID:23329134   PMID:23650188   PMID:23676495   PMID:25548259   PMID:25617349   PMID:26853145   PMID:27544029   PMID:28422089   PMID:29425239   PMID:29530023  
PMID:30369479   PMID:30700132   PMID:33549451  


Genomics

Comparative Map Data
Apoa5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39946,179,906 - 46,183,219 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl946,179,931 - 46,183,217 (+)EnsemblGRCm39 Ensembl
GRCm38946,268,608 - 46,271,921 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,268,633 - 46,271,919 (+)EnsemblGRCm38mm10GRCm38
MGSCv37946,076,691 - 46,080,002 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36946,019,603 - 46,022,914 (+)NCBIMGSCv36mm8
Celera943,557,616 - 43,560,927 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.37NCBI
APOA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811116,789,367 - 116,792,420 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11116,789,367 - 116,792,420 (-)EnsemblGRCh38hg38GRCh38
GRCh3711116,660,083 - 116,663,136 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,165,296 - 116,167,794 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411116,165,296 - 116,167,794NCBI
Celera11113,815,476 - 113,818,526 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11112,592,079 - 112,595,129 (-)NCBIHuRef
CHM1_111116,544,726 - 116,547,776 (-)NCBICHM1_1
T2T-CHM13v2.011116,803,991 - 116,807,044 (-)NCBIT2T-CHM13v2.0
Apoa5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2846,561,180 - 46,563,818 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,561,229 - 46,563,816 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx852,062,457 - 52,065,145 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0850,341,227 - 50,343,915 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0848,205,503 - 48,208,191 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0850,559,079 - 50,561,720 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,559,126 - 50,561,736 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0849,185,041 - 49,187,682 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4849,253,538 - 49,255,777 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1849,265,341 - 49,267,579 (+)NCBI
Celera846,142,946 - 46,145,584 (+)NCBICelera
Cytogenetic Map8q22NCBI
Apoa5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,129,603 - 18,131,115 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,128,861 - 18,131,752 (-)NCBIChiLan1.0ChiLan1.0
APOA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan111118,595,361 - 118,597,891 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011111,625,403 - 111,627,932 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111115,559,231 - 115,562,286 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,559,231 - 115,562,286 (-)Ensemblpanpan1.1panPan2
APOA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1516,774,117 - 16,777,535 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl516,774,501 - 16,777,768 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha516,826,641 - 16,829,696 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0516,721,181 - 16,724,236 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl516,721,199 - 16,723,685 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1516,858,043 - 16,861,098 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0516,760,620 - 16,763,675 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0516,803,753 - 16,806,810 (+)NCBIUU_Cfam_GSD_1.0
Apoa5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494799,147,591 - 99,149,935 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,069,683 - 2,071,353 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365422,069,683 - 2,071,344 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,178,606 - 44,180,885 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,177,834 - 44,180,880 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,251,674 - 49,254,883 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APOA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,154,880 - 108,158,998 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1108,155,641 - 108,157,375 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604317,891,675 - 17,894,161 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoa5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478412,213,744 - 12,216,026 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478412,213,205 - 12,216,039 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apoa5
83 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:862
Count of miRNA genes:303
Interacting mature miRNAs:325
Transcripts:ENSMUST00000034584, ENSMUST00000121598
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93673624349420511Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93694340650111140Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94041959451808670Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
11532693Sluc39_msusceptibility to lung cancer 39 (mouse)94064537448351476Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
13432191Actrse4_mactivity response to saline/ethanol 4 (mouse)94370321448603195Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse

Markers in Region
AI046360  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38946,271,278 - 46,271,382UniSTSGRCm38
MGSCv37946,079,361 - 46,079,465UniSTSGRCm37
Celera943,560,286 - 43,560,390UniSTS
Cytogenetic Map9BUniSTS
Cytogenetic Map9A5.2UniSTS
Whitehead/MRC_RH9500.1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034584   ⟹   ENSMUSP00000034584
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl946,180,376 - 46,183,217 (+)Ensembl
GRCm38.p6 Ensembl946,269,078 - 46,271,919 (+)Ensembl
RefSeq Acc Id: ENSMUST00000121598   ⟹   ENSMUSP00000113413
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl946,179,931 - 46,183,217 (+)Ensembl
GRCm38.p6 Ensembl946,268,633 - 46,271,919 (+)Ensembl
RefSeq Acc Id: ENSMUST00000213878   ⟹   ENSMUSP00000149135
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl946,180,376 - 46,181,867 (+)Ensembl
GRCm38.p6 Ensembl946,269,078 - 46,270,569 (+)Ensembl
RefSeq Acc Id: ENSMUST00000214202   ⟹   ENSMUSP00000149834
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl946,180,376 - 46,181,481 (+)Ensembl
GRCm38.p6 Ensembl946,269,078 - 46,270,183 (+)Ensembl
RefSeq Acc Id: ENSMUST00000215187   ⟹   ENSMUSP00000151068
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl946,180,376 - 46,181,710 (+)Ensembl
GRCm38.p6 Ensembl946,269,078 - 46,270,412 (+)Ensembl
RefSeq Acc Id: ENSMUST00000215458   ⟹   ENSMUSP00000149877
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl946,180,376 - 46,181,495 (+)Ensembl
GRCm38.p6 Ensembl946,269,078 - 46,270,197 (+)Ensembl
RefSeq Acc Id: NM_001348095   ⟹   NP_001335024
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39946,179,931 - 46,183,219 (+)NCBI
GRCm38946,268,633 - 46,271,921 (+)NCBI
Sequence:
RefSeq Acc Id: NM_080434   ⟹   NP_536682
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39946,179,906 - 46,183,219 (+)NCBI
GRCm38946,268,608 - 46,271,921 (+)NCBI
MGSCv37946,076,691 - 46,080,002 (+)RGD
Celera943,557,616 - 43,560,927 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_536682   ⟸   NM_080434
- Peptide Label: precursor
- UniProtKB: Q91X90 (UniProtKB/Swiss-Prot),   Q99P64 (UniProtKB/Swiss-Prot),   Q8C7G5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001335024   ⟸   NM_001348095
- Peptide Label: precursor
- UniProtKB: Q91X90 (UniProtKB/Swiss-Prot),   Q99P64 (UniProtKB/Swiss-Prot),   Q8C7G5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000034584   ⟸   ENSMUST00000034584
RefSeq Acc Id: ENSMUSP00000113413   ⟸   ENSMUST00000121598
RefSeq Acc Id: ENSMUSP00000149135   ⟸   ENSMUST00000213878
RefSeq Acc Id: ENSMUSP00000151068   ⟸   ENSMUST00000215187
RefSeq Acc Id: ENSMUSP00000149877   ⟸   ENSMUST00000215458
RefSeq Acc Id: ENSMUSP00000149834   ⟸   ENSMUST00000214202

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C7G5-F1-model_v2 AlphaFold Q8C7G5 1-368 view protein structure

Promoters
RGD ID:6844176
Promoter ID:MM_KWN:57222
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000034584,   ENSMUST00000121598,   NM_080434
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36946,076,531 - 46,077,031 (+)MPROMDB
RGD ID:8669484
Promoter ID:EPDNEW_M12773
Type:multiple initiation site
Name:Apoa5_1
Description:Mus musculus apolipoprotein A-V , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M12774  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38946,268,608 - 46,268,668EPDNEW
RGD ID:8669540
Promoter ID:EPDNEW_M12774
Type:multiple initiation site
Name:Apoa5_2
Description:Mus musculus apolipoprotein A-V , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M12773  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38946,269,072 - 46,269,132EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913363 AgrOrtholog
Ensembl Genes ENSMUSG00000032079 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034584 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000121598 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000213878.2 UniProtKB/TrEMBL
  ENSMUST00000214202.2 UniProtKB/TrEMBL
  ENSMUST00000215187.2 UniProtKB/TrEMBL
  ENSMUST00000215458.2 UniProtKB/TrEMBL
Gene3D-CATH Apolipoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ApoA_E UniProtKB/Swiss-Prot
KEGG Report mmu:66113 UniProtKB/Swiss-Prot
MGD MGI:1913363 ENTREZGENE
NCBI Gene 66113 ENTREZGENE
PANTHER APOLIPOPROTEIN UniProtKB/Swiss-Prot
  APOLIPOPROTEIN A-V UniProtKB/Swiss-Prot
Pfam Apolipoprotein UniProtKB/Swiss-Prot
PharmGKB APOA5 RGD
PhenoGen Apoa5 PhenoGen
Superfamily-SCOP Apolipoprotein UniProtKB/TrEMBL
  Apolipoprotein A-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SQP3_MOUSE UniProtKB/TrEMBL
  A0A1L1SSC4_MOUSE UniProtKB/TrEMBL
  A0A1L1SSE5_MOUSE UniProtKB/TrEMBL
  A0A1L1SV61_MOUSE UniProtKB/TrEMBL
  APOA5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q91X90 ENTREZGENE
  Q99P64 ENTREZGENE
UniProt Secondary Q91X90 UniProtKB/Swiss-Prot
  Q99P64 UniProtKB/Swiss-Prot