(+)-alpha-tocopherol affects localization ISO RGD:2266 6480464 alpha-Tocopherol affects the localization of CANX protein CTD PMID:16908007 (+)-alpha-tocopherol increases expression ISO RGD:2266 6480464 alpha-Tocopherol results in increased expression of CANX mRNA, alpha-Tocopherol results in increased expression of CANX protein CTD PMID:16908007 17beta-estradiol increases expression ISO RGD:737068 6480464 Estradiol results in increased expression of CANX mRNA CTD PMID:19167446 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one multiple interactions ISO RGD:737068 6480464 Metribolone promotes the reaction [NDRG1 protein binds to CANX protein] CTD PMID:17220478 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of CANX mRNA CTD PMID:21570461 , PMID:24680724 2,4-dinitrotoluene affects expression ISO RGD:2266 6480464 2, 4-dinitrotoluene affects the expression of CANX mRNA CTD PMID:21346803 3,4-methylenedioxymethamphetamine decreases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of CANX mRNA CTD PMID:26251327 3H-1,2-dithiole-3-thione decreases expression ISO RGD:2266 6480464 1, 2-dithiol-3-thione results in decreased expression of CANX mRNA CTD PMID:19162173 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of CANX mRNA CTD PMID:28973697 4-hydroxyphenyl retinamide increases expression ISO RGD:737068 6480464 Fenretinide results in increased expression of CANX protein CTD PMID:17353921 5-fluorouracil multiple interactions ISO RGD:737068 6480464 CANX results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine], TP53 protein affects the reaction [Fluorouracil results in decreased expression of CANX mRNA] CTD PMID:15016801 , PMID:18678097 acetylsalicylic acid decreases expression ISO RGD:737068 6480464 Aspirin results in decreased expression of CANX mRNA CTD PMID:15928584 acrylamide affects expression ISO RGD:2266 6480464 Acrylamide affects the expression of CANX mRNA CTD PMID:28959563 aflatoxin B1 decreases methylation ISO RGD:737068 6480464 Aflatoxin B1 results in decreased methylation of CANX gene CTD PMID:27153756 aldehydo-D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of CANX mRNA CTD PMID:17178593 ammonium chloride affects expression ISO RGD:2266 6480464 Ammonium Chloride affects the expression of CANX mRNA CTD PMID:16483693 ammonium chloride decreases expression ISO RGD:2266 6480464 Ammonium Chloride results in decreased expression of CANX protein CTD PMID:16483693 arsenous acid multiple interactions ISO RGD:737068 6480464 Resveratrol inhibits the reaction [Arsenic Trioxide results in increased expression of CANX protein] CTD PMID:25107562 arsenous acid increases expression ISO RGD:737068 6480464 Arsenic Trioxide results in increased expression of CANX mRNA, Arsenic Trioxide results in increased expression of CANX protein CTD PMID:20458559 , PMID:25107562 arsenous acid decreases expression ISO RGD:737068 6480464 Arsenic Trioxide results in decreased expression of CANX protein CTD PMID:25419056 bexarotene increases expression ISO RGD:2266 6480464 bexarotene results in increased expression of CANX mRNA CTD PMID:16648578 bis(2-chloroethyl) sulfide increases phosphorylation ISO RGD:737068 6480464 Mustard Gas results in increased phosphorylation of CANX protein CTD PMID:19845377 bisphenol A decreases expression ISO RGD:2266 6480464 bisphenol A results in decreased expression of CANX mRNA CTD PMID:25181051 bisphenol A affects expression ISO RGD:737068 6480464 bisphenol A affects the expression of CANX mRNA CTD PMID:30903817 bisphenol A decreases methylation ISO RGD:2266 6480464 bisphenol A results in decreased methylation of CANX gene CTD PMID:28505145 bisphenol A increases methylation ISO RGD:2266 6480464 bisphenol A results in increased methylation of CANX gene CTD PMID:28505145 Brodifacoum increases expression ISO RGD:2266 6480464 bromfenacoum results in increased expression of CANX protein CTD PMID:28903499 C60 fullerene decreases expression ISO RGD:2266 6480464 fullerene C60 results in decreased expression of CANX mRNA CTD PMID:19167457 calcidiol decreases expression ISO RGD:2266 6480464 Calcifediol deficiency results in decreased expression of CANX mRNA CTD PMID:17293106 capecitabine multiple interactions ISO RGD:737068 6480464 CANX results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 carbon nanotube affects expression ISO RGD:737068 6480464 Nanotubes, Carbon affects the expression of CANX protein CTD PMID:22001959 carboplatin decreases expression ISO RGD:2266 6480464 Carboplatin results in decreased expression of CANX mRNA CTD PMID:18172885 CCCP affects localization ISO RGD:737068 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of CANX protein CTD PMID:28940366 cefaloridine increases expression ISO RGD:2266 6480464 Cephaloridine results in increased expression of CANX mRNA CTD PMID:18172885 cisplatin multiple interactions ISO RGD:737068 6480464 [Piroxicam co-treated with Cisplatin] results in increased expression of CANX mRNA CTD PMID:21858171 cisplatin decreases expression ISO RGD:737068 6480464 Cisplatin results in decreased expression of CANX mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:2266 6480464 Cisplatin results in decreased expression of CANX mRNA CTD PMID:18246545 clofibrate decreases expression ISO RGD:2266 6480464 Clofibrate results in decreased expression of CANX mRNA CTD PMID:21318169 cobalt dichloride increases expression ISO RGD:737068 6480464 cobaltous chloride results in increased expression of CANX mRNA CTD PMID:17553155 copper(II) sulfate decreases expression ISO RGD:737068 6480464 Copper Sulfate results in decreased expression of CANX mRNA CTD PMID:19549813 cyclophosphamide decreases expression ISO RGD:2266 6480464 Cyclophosphamide results in decreased expression of CANX mRNA CTD PMID:11906922 cyclosporin A increases expression ISO RGD:737068 6480464 Cyclosporine results in increased expression of CANX mRNA CTD PMID:20106945 , PMID:27989131 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of CANX mRNA CTD PMID:25270620 cyclosporin A increases expression ISO RGD:2266 6480464 Cyclosporine results in increased expression of CANX mRNA CTD PMID:18172885 D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of CANX mRNA CTD PMID:17178593 DDT decreases expression ISO RGD:2266 6480464 DDT results in decreased expression of CANX mRNA CTD PMID:30207508 deoxynivalenol decreases phosphorylation EXP 6480464 deoxynivalenol results in decreased phosphorylation of CANX protein CTD PMID:23811945 diarsenic trioxide increases expression ISO RGD:737068 6480464 Arsenic Trioxide results in increased expression of CANX mRNA, Arsenic Trioxide results in increased expression of CANX protein CTD PMID:20458559 , PMID:25107562 diarsenic trioxide multiple interactions ISO RGD:737068 6480464 Resveratrol inhibits the reaction [Arsenic Trioxide results in increased expression of CANX protein] CTD PMID:25107562 diarsenic trioxide decreases expression ISO RGD:737068 6480464 Arsenic Trioxide results in decreased expression of CANX protein CTD PMID:25419056 diazinon increases methylation ISO RGD:737068 6480464 Diazinon results in increased methylation of CANX gene CTD PMID:22964155 Dinophysistoxin 1 increases expression ISO RGD:737068 6480464 dinophysistoxin 1 results in increased expression of CANX mRNA CTD PMID:28939011 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of CANX mRNA CTD PMID:24205000 diuron decreases expression ISO RGD:2266 6480464 Diuron results in decreased expression of CANX mRNA CTD PMID:21551480 doxorubicin affects expression ISO RGD:737068 6480464 Doxorubicin affects the expression of CANX protein CTD PMID:29385562 doxorubicin decreases expression ISO RGD:737068 6480464 Doxorubicin results in decreased expression of CANX mRNA CTD PMID:29803840 efavirenz affects localization ISO RGD:737068 6480464 efavirenz affects the localization of CANX protein CTD PMID:28940366 emodin decreases expression ISO RGD:737068 6480464 Emodin results in decreased expression of CANX mRNA CTD PMID:16045814 enzyme inhibitor multiple interactions ISO RGD:737068 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CANX protein CTD PMID:23301498 ethanol affects expression ISO RGD:2266 6480464 Ethanol affects the expression of CANX mRNA CTD PMID:11772933 ethanol multiple interactions ISO RGD:737068 6480464 [[Gasoline co-treated with Ethanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of CANX mRNA CTD PMID:29432896 fenofibrate increases expression EXP 6480464 Fenofibrate results in increased expression of CANX mRNA CTD PMID:21318169 fenofibrate multiple interactions EXP 6480464 PPARA protein affects the reaction [Fenofibrate results in increased expression of CANX mRNA] CTD PMID:21318169 ferric oxide decreases expression EXP 6480464 ferric oxide results in decreased expression of CANX protein CTD PMID:25086211 flutamide increases expression ISO RGD:2266 6480464 Flutamide results in increased expression of CANX mRNA CTD PMID:24136188 formaldehyde decreases expression ISO RGD:737068 6480464 Formaldehyde results in decreased expression of CANX mRNA CTD PMID:23649840 genistein multiple interactions ISO RGD:737068 6480464 ESR2 promotes the reaction [Genistein results in increased expression of CANX protein] CTD PMID:20884965 genistein increases expression ISO RGD:737068 6480464 Genistein results in increased expression of CANX protein CTD PMID:20884965 gentamycin increases expression ISO RGD:2266 6480464 Gentamicins results in increased expression of CANX mRNA CTD PMID:18172885 , PMID:22061828 glucose decreases expression EXP 6480464 Glucose results in decreased expression of CANX mRNA CTD PMID:17178593 hydralazine multiple interactions ISO RGD:737068 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of CANX mRNA CTD PMID:17183730 hydrogen peroxide affects expression ISO RGD:737068 6480464 Hydrogen Peroxide affects the expression of CANX protein CTD PMID:21179406 hypochlorous acid increases expression EXP 6480464 Hypochlorous Acid results in increased expression of CANX mRNA CTD PMID:19376150 iron(III) nitrilotriacetate increases expression ISO RGD:2266 6480464 ferric nitrilotriacetate results in increased expression of CANX protein CTD PMID:16908007 menadione affects expression ISO RGD:737068 6480464 Vitamin K 3 affects the expression of CANX mRNA CTD PMID:20044591 methyl methanesulfonate decreases expression ISO RGD:737068 6480464 Methyl Methanesulfonate results in decreased expression of CANX mRNA CTD PMID:23649840 methylmercury chloride increases expression ISO RGD:737068 6480464 methylmercuric chloride results in increased expression of CANX mRNA CTD PMID:26272509 miglustat multiple interactions ISO RGD:737068 6480464 miglustat inhibits the reaction [CANX protein binds to CFTR protein mutant form] CTD PMID:18230692 motexafin gadolinium increases expression ISO RGD:737068 6480464 motexafin gadolinium results in increased expression of CANX mRNA CTD PMID:16357179 motexafin gadolinium multiple interactions ISO RGD:737068 6480464 [Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CANX mRNA CTD PMID:16357179 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal affects localization ISO RGD:737068 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the localization of CANX protein CTD PMID:17912641 nickel atom multiple interactions EXP 6480464 MT1 affects the reaction [Nickel affects the expression of CANX mRNA], MT2 affects the reaction [Nickel affects the expression of CANX mRNA] CTD PMID:16166738 nickel sulfate decreases expression ISO RGD:737068 6480464 nickel sulfate results in decreased expression of CANX mRNA CTD PMID:16780908 nimesulide increases expression ISO RGD:2266 6480464 nimesulide results in increased expression of CANX mRNA CTD PMID:24136188 okadaic acid increases expression ISO RGD:737068 6480464 Okadaic Acid results in increased expression of CANX mRNA CTD PMID:28939011 ouabain increases expression ISO RGD:737068 6480464 Ouabain results in increased expression of CANX protein CTD PMID:18247327 piroxicam multiple interactions ISO RGD:737068 6480464 [Piroxicam co-treated with Cisplatin] results in increased expression of CANX mRNA CTD PMID:21858171 potassium dichromate increases expression ISO RGD:737068 6480464 Potassium Dichromate results in increased expression of CANX mRNA CTD PMID:18332044 propiconazole increases expression EXP 6480464 propiconazole results in increased expression of CANX mRNA CTD PMID:21278054 resveratrol multiple interactions ISO RGD:737068 6480464 resveratrol inhibits the reaction [arsenic trioxide results in increased expression of CANX protein] CTD PMID:25107562 silicon dioxide increases expression ISO RGD:2266 6480464 Silicon Dioxide results in increased expression of CANX mRNA CTD PMID:22431001 sodium arsenate increases expression EXP 6480464 sodium arsenate results in increased expression of CANX mRNA CTD PMID:21795629 sodium arsenite decreases expression ISO RGD:737068 6480464 sodium arsenite results in decreased expression of CANX mRNA CTD PMID:28595984 sodium arsenite decreases expression ISO RGD:2266 6480464 sodium arsenite results in decreased expression of CANX protein CTD PMID:29459688 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of CANX mRNA CTD PMID:22155349 sodium dichromate increases expression ISO RGD:2266 6480464 sodium bichromate results in increased expression of CANX mRNA CTD PMID:12325037 sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of CANX protein CTD PMID:27548804 succimer multiple interactions EXP 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CANX mRNA, [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CANX mRNA CTD PMID:21641980 , PMID:26378955 tauroursodeoxycholic acid multiple interactions ISO RGD:737068 6480464 tauroursodeoxycholic acid inhibits the reaction [Tunicamycin results in increased expression of CANX protein] CTD PMID:27588471 thapsigargin increases expression ISO RGD:737068 6480464 Thapsigargin results in increased expression of CANX mRNA, Thapsigargin results in increased expression of CANX protein CTD PMID:17353921 more ... thapsigargin affects localization ISO RGD:737068 6480464 Thapsigargin affects the localization of CANX protein CTD PMID:28940366 thapsigargin increases expression ISO RGD:2266 6480464 Thapsigargin results in increased expression of CANX protein CTD PMID:28315715 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of CANX mRNA CTD PMID:23557971 trichloroethene increases expression ISO RGD:2266 6480464 Trichloroethylene results in increased expression of CANX mRNA CTD PMID:19448997 trichloroethene decreases methylation ISO RGD:2266 6480464 Trichloroethylene results in decreased methylation of CANX gene CTD PMID:27618143 tunicamycin multiple interactions ISO RGD:737068 6480464 ERGIC3 protein inhibits the reaction [Tunicamycin results in increased expression of CANX protein], tauroursodeoxycholic acid inhibits the reaction [Tunicamycin results in increased expression of CANX protein] CTD PMID:27588471 tunicamycin increases expression ISO RGD:737068 6480464 Tunicamycin results in increased expression of CANX mRNA, Tunicamycin results in increased expression of CANX protein CTD PMID:22378314 more ... uranium atom affects expression ISO RGD:737068 6480464 Uranium affects the expression of CANX mRNA CTD PMID:15672453 valproic acid multiple interactions ISO RGD:737068 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of CANX mRNA CTD PMID:17183730 valproic acid increases expression ISO RGD:737068 6480464 Valproic Acid results in increased expression of CANX mRNA CTD PMID:23179753 , PMID:27188386 valproic acid affects expression ISO RGD:737068 6480464 Valproic Acid affects the expression of CANX mRNA CTD PMID:25979313 vinclozolin affects expression ISO RGD:2266 6480464 vinclozolin affects the expression of CANX mRNA CTD PMID:19015723 vitamin E increases expression ISO RGD:2266 6480464 alpha-Tocopherol results in increased expression of CANX mRNA, alpha-Tocopherol results in increased expression of CANX protein CTD PMID:16908007 vitamin E affects localization ISO RGD:2266 6480464 alpha-Tocopherol affects the localization of CANX protein CTD PMID:16908007 zinc acetate increases expression ISO RGD:737068 6480464 Zinc Acetate results in increased expression of CANX mRNA CTD PMID:16357179 zinc acetate multiple interactions ISO RGD:737068 6480464 [Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CANX mRNA CTD PMID:16357179
Biological Process clathrin-dependent endocytosis IMP 2290270 (MGI:MGI:5288282, PMID:21747946) UniProtKB MGI:MGI:5288282 , PMID:21747946 endoplasmic reticulum unfolded protein response IBA PANTHER:PTN000117401 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 protein folding IBA PANTHER:PTN000117401 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 protein folding IBA PANTHER:PTN000117401 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 synaptic vesicle endocytosis IMP 2290270 (MGI:MGI:5288282, PMID:21747946) SynGO MGI:MGI:5288282 , PMID:21747946 synaptic vesicle endocytosis IDA 2290270 (MGI:MGI:5288282, PMID:21747946) SynGO MGI:MGI:5288282 , PMID:21747946 Cellular Component axon ISO RGD:2266 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cytoplasm ISO RGD:2266 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 dendrite cytoplasm ISO RGD:2266 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 dendritic spine ISO RGD:2266 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 endoplasmic reticulum ISO UniProtKB:P35565 2290270 (MGI:MGI:3848633, PMID:19474315) MGI MGI:MGI:3848633 , PMID:19474315 endoplasmic reticulum IDA 2290270 (MGI:MGI:1196819 more ... MGI MGI:MGI:1196819 more ... endoplasmic reticulum ISO UniProtKB:P27824 2290270 (MGI:MGI:3040558 more ... MGI GO_REF:0000096 more ... endoplasmic reticulum ISO RGD:2266 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 endoplasmic reticulum membrane IBA MGI:MGI:88252 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 endoplasmic reticulum membrane ISO UniProtKB:P27824 2290270 (MGI:MGI:4462742, PMID:20531390) MGI GO_REF:0000008 more ... endoplasmic reticulum quality control compartment IDA 2290270 (MGI:MGI:6120598, PMID:11408579) UniProtKB MGI:MGI:6120598 , PMID:11408579 glutamatergic synapse ISO RGD:2266 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 integral component of membrane IDA 2290270 (MGI:MGI:2674181, PMID:12927782) MGI MGI:MGI:2674181 , PMID:12927782 integral component of postsynaptic membrane ISO RGD:2266 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 integral component of presynaptic active zone membrane ISO RGD:2266 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 membrane IDA 2290270 (MGI:MGI:5494355, PMID:22375059) MGI MGI:MGI:5494355 , PMID:22375059 mitochondria-associated endoplasmic reticulum membrane ISO UniProtKB:P27824 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 myelin sheath HDA 2290270 (MGI:MGI:3834050, PMID:17634366) UniProt MGI:MGI:3834050 , PMID:17634366 neuronal cell body ISO RGD:2266 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein-containing complex ISO RGD:2266 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 ribosome ISO RGD:2266 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 rough endoplasmic reticulum colocalizes_with ISO RGD:2266 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 smooth endoplasmic reticulum ISO RGD:2266 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Molecular Function apolipoprotein binding ISO RGD:2266 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 calcium ion binding IBA MGI:MGI:107472 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 carbohydrate binding IEA UniProtKB-KW:KW-0430 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 ionotropic glutamate receptor binding ISO RGD:2266 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 protein binding IPI UniProtKB:Q8VD37-6 2290270 (MGI:MGI:5288282, PMID:21747946) MGI MGI:MGI:5288282 , PMID:21747946 protein binding IPI UniProtKB:P02716 more ... 2290270 (MGI:MGI:82783, PMID:8798466) MGI MGI:MGI:82783 , PMID:8798466 unfolded protein binding IEA InterPro:IPR001580 2290270 UniProt GO_REF:0000002, MGI:MGI:2152098
Gene-Chemical Interaction Annotations
