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Gene: Clock (circadian locomotor output cycles kaput) Mus musculus
Symbol: Clock
Name: circadian locomotor output cycles kaput
Description: Exhibits DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and histone acetyltransferase activity. Involved in several processes, including cellular protein metabolic process; negative regulation of glucocorticoid receptor signaling pathway; and regulation of gene expression. Localizes to chromatoid body; nucleus; and transcription factor complex. Used to study bipolar disorder; diabetes mellitus; and sleep disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in several structures, including alimentary system; ear; early conceptus; genitourinary system; and nervous system. Orthologous to human CLOCK (clock circadian regulator).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5330400M04Rik; bHLHe8; circadian locomoter output cycles kaput; circadian locomoter output cycles protein kaput; KAT13D; mCLOCK; mKIAA0334
Homo sapiens (human) : CLOCK (clock circadian regulator)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Clock (clock circadian regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clock (clock circadian regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : CLOCK (clock circadian regulator)
Canis lupus familiaris (dog) : CLOCK (clock circadian regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clock (clock circadian regulator)
Sus scrofa (pig) : CLOCK (clock circadian regulator)
Chlorocebus sabaeus (African green monkey) : CLOCK (clock circadian regulator)
Heterocephalus glaber (naked mole-rat) : Clock (clock circadian regulator)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl576,209,868 - 76,304,792 (-)EnsemblGRCm38mm10GRCm38
GRCm38576,209,868 - 76,305,603 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37576,641,202 - 76,733,573 (-)NCBIGRCm37mm9NCBIm37
MGSCv36577,286,952 - 77,379,323 (-)NCBImm8
Celera573,483,631 - 73,569,902 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map540.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Clock
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552430
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.