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Gene: Disc1 (disrupted in schizophrenia 1) Mus musculus
Symbol: Disc1
Name: disrupted in schizophrenia 1
Description: Exhibits molecular adaptor activity. Involved in several processes, including mitochondrial calcium ion homeostasis; nervous system development; and non-motile cilium assembly. Localizes to the microtubule organizing center; postsynaptic density; and synaptic vesicle. Used to study endogenous depression and schizophrenia. Human ortholog(s) of this gene implicated in autism spectrum disorder (multiple); bipolar disorder; chronic fatigue syndrome; major depressive disorder; and psychotic disorder (multiple). Is expressed in brain. Orthologous to human DISC1 (DISC1 scaffold protein); INTERACTS WITH 1,2-dichloroethane; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: disrupted in schizophrenia 1 homolog
Homo sapiens (human) : DISC1 (DISC1 scaffold protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Disc1 (DISC1 scaffold protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Disc1 (DISC1 scaffold protein)
Canis lupus familiaris (dog) : DISC1 (DISC1 scaffold protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101959679 (disrupted in schizophrenia 1 protein)
Sus scrofa (pig) : DISC1 (DISC1 scaffold protein)
Chlorocebus sabaeus (African green monkey) : DISC1 (DISC1 scaffold protein)
Heterocephalus glaber (naked mole-rat) : Disc1 (DISC1 scaffold protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl8125,054,195 - 125,261,858 (+)EnsemblGRCm38mm10GRCm38
GRCm388125,048,767 - 125,265,143 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv378127,578,095 - 127,785,051 (+)NCBIGRCm37mm9NCBIm37
MGSCv368127,940,285 - 128,148,274 (+)NCBImm8
Celera8129,364,004 - 129,569,546 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map873.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Disc1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1332081
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.