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Gene: Disc1 (disrupted in schizophrenia 1) Mus musculus
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Symbol: Disc1
Name: disrupted in schizophrenia 1
Description: Exhibits molecular adaptor activity. Involved in several processes, including mitochondrial calcium ion homeostasis; nervous system development; and non-motile cilium assembly. Localizes to the microtubule organizing center; postsynaptic density; and synaptic vesicle. Used to study endogenous depression and schizophrenia. Human ortholog(s) of this gene implicated in autism spectrum disorder (multiple); bipolar disorder; chronic fatigue syndrome; major depressive disorder; and psychotic disorder (multiple). Is expressed in brain. Orthologous to human DISC1 (DISC1 scaffold protein); INTERACTS WITH 1,2-dichloroethane; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: disrupted in schizophrenia 1 homolog
Orthologs:
Homo sapiens (human) : DISC1 (DISC1 scaffold protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Disc1 (DISC1 scaffold protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Disc1 (DISC1 scaffold protein)
Canis lupus familiaris (dog) : DISC1 (DISC1 scaffold protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101959679 (disrupted in schizophrenia 1 protein)
Sus scrofa (pig) : DISC1 (DISC1 scaffold protein)
Chlorocebus sabaeus (African green monkey) : DISC1 (DISC1 scaffold protein)
Heterocephalus glaber (naked mole-rat) : Disc1 (DISC1 scaffold protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl8125,054,195 - 125,261,858 (+)EnsemblGRCm38mm10GRCm38
GRCm388125,048,767 - 125,265,143 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv378127,578,095 - 127,785,051 (+)NCBIGRCm37mm9NCBIm37
MGSCv368127,940,285 - 128,148,274 (+)NCBImm8
Celera8129,364,004 - 129,569,546 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map873.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Disc1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1332081
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.