RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Chemical and Drug Induced Liver Injury
Accession: DOID:9007383
browse the term
Definition: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
Synonyms: exact_synonym: Chemically Induced Liver Toxicity; Drug Induced Acute Liver Injury; Drug Induced Liver Disease; Drug Induced Liver Injury; Drug-Induced Liver Diseases; Drug-Induced Liver Injuries; Toxic Hepatitis; chemically-induced liver toxicities; hepatotoxicity; toxic hepatitides
narrow_synonym: Drug-induced liver injury due to flucloxacillin
primary_id: MESH:D056486
alt_id: RDO:0007742
xref: EFO:0004228 ; EFO:0011052 ; NCI:C84427
Symbol
Object Name
Qualifiers
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
Aass
aminoadipate-semialdehyde synthase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 4:52,572,146...52,628,811
Ensembl chr 4:51,606,462...51,663,136
G
Abcb11
ATP binding cassette subfamily B member 11
severity
ISO
DNA:SNP: :rs2287616(human)
RGD
PMID:27293027
RGD:14402413
NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730
G
Abcb1a
ATP binding cassette subfamily B member 1A
severity susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:SNP::2677G>T/A(rs2032582)(human)
CTD RGD
PMID:20623750 PMID:26134275 PMID:26134275 PMID:27296832
RGD:11041130 , RGD:14700895
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
G
Abcb1b
ATP-binding cassette, sub-family B member 1B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27193730
NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199
G
Abcc1
ATP binding cassette subfamily C member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18466103
NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
G
Abcc2
ATP binding cassette subfamily C member 2
susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:polymorphism:promoter:-24C>T(human)
CTD RGD
PMID:18381794 PMID:18466103 PMID:25196354 PMID:17241877
RGD:14700812 , RGD:14700814
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
G
Abi1
abl-interactor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr17:90,006,917...90,088,002
Ensembl chr17:85,098,550...85,179,792
G
Ace
angiotensin I converting enzyme
IEP
mRNA:increased expression:liver (rat)
RGD
PMID:25143335
RGD:25671447
NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131
G
Acox3
acyl-CoA oxidase 3, pristanoyl
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr14:79,358,604...79,405,160
Ensembl chr14:75,094,676...75,176,205
G
Acsl1
acyl-CoA synthetase long-chain family member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr16:52,487,870...52,554,110
Ensembl chr16:45,755,254...45,821,541
G
Actb
actin, beta
IEP ISO
mRNA:increased expression:liver CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:25231249 PMID:22563491
RGD:9587759
NCBI chr12:16,776,664...16,779,634
Ensembl chr12:11,663,109...11,672,877
G
Actn4
actinin alpha 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 1:93,310,294...93,379,369
Ensembl chr 1:84,182,788...84,251,847
G
Actr3
actin related protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr13:39,353,413...39,396,509
Ensembl chr13:36,800,093...36,844,124
G
Ada
adenosine deaminase
IEP
protein:increased expression:liver
RGD
PMID:21161045
RGD:5128859
NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088
G
Adam8
ADAM metallopeptidase domain 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24646716
NCBI chr 1:204,206,206...204,218,988
Ensembl chr 1:194,770,060...194,788,801
G
Adipoq
adiponectin, C1Q and collagen domain containing
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20709802
NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564
G
Adipor2
adiponectin receptor 2
severity
IEP
associated with obesity, LPS;mRNA:decreased expression:liver (rat)
RGD
PMID:23838384
RGD:8695926
NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:152,524,623...152,559,355
G
Adora2b
adenosine A2B receptor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:35292334
NCBI chr10:47,439,712...47,456,092
Ensembl chr10:46,940,384...46,956,772
G
Agt
angiotensinogen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29499335
NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977
G
Ahr
aryl hydrocarbon receptor
ISO IEP
CTD Direct Evidence: marker/mechanism|therapeutic mRNA:decreased expression:liver (rat)
CTD RGD
PMID:21890736 PMID:34848246 PMID:28959666
RGD:401794432
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
G
Aifm1
apoptosis inducing factor, mitochondria associated 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25743375
NCBI chr X:132,528,107...132,567,237
Ensembl chr X:127,650,226...127,689,256
G
Ak4
adenylate kinase 4
IEP
protein:increased expression:liver (rat)
RGD
PMID:16538043
RGD:2301096
NCBI chr 5:121,154,565...121,214,403
Ensembl chr 5:116,039,616...116,098,618
G
Akr1a1
aldo-keto reductase family 1 member A1
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:32805337 PMID:29763686
RGD:27226688
NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:130,092,732...130,113,674
G
Alb
albumin
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:18779383 PMID:22310181 PMID:27567545
RGD:14694844
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
G
Aldh1l2
aldehyde dehydrogenase 1 family, member L2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 7:22,141,872...22,193,403
Ensembl chr 7:20,254,233...20,305,776
G
Aldh2
aldehyde dehydrogenase 2 family member
susceptibility severity
IEP ISO
protein:increased expression:liver DNA:deletion:exon 3 (mouse)
RGD
PMID:21138988 PMID:24492981 PMID:30121625
RGD:7241599 , RGD:14975148 , RGD:15036810
NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521
G
Aldh9a1
aldehyde dehydrogenase 9 family, member A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr13:82,038,679...82,055,478
Ensembl chr13:79,505,695...79,540,568
G
Aldob
aldolase, fructose-bisphosphate B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16115720
NCBI chr 5:68,684,541...68,697,582
Ensembl chr 5:63,889,046...63,902,116
G
Ambp
alpha-1-microglobulin/bikunin precursor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18779383
NCBI chr 5:81,583,621...81,593,938
Ensembl chr 5:76,568,094...76,578,331
G
Anxa2
annexin A2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:70,105,253...70,141,658
G
Anxa6
annexin A6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr10:39,602,106...39,657,183
Ensembl chr10:39,097,109...39,156,433
G
Apoa1
apolipoprotein A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035
G
Apoe
apolipoprotein E
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932
G
Apoh
apolipoprotein H
IEP ISO
mRNA:increased expression:plasma: CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:16099942 PMID:23288050
RGD:10054107
NCBI chr10:93,841,992...93,855,897
Ensembl chr10:93,310,977...93,356,329
G
Arg1
arginase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22872058
NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:20,475,968...20,488,422
G
Arnt
aryl hydrocarbon receptor nuclear translocator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20935161
NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:182,997,736...183,056,580
G
Atg5
autophagy related 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22491424
NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209
G
Atoh8
atonal bHLH transcription factor 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 4:105,818,203...105,850,379
Ensembl chr 4:104,259,992...104,292,168
G
Atp6v1d
ATPase H+ transporting V1 subunit D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303
G
Avp
arginine vasopressin
ISO
DNA:SNP:intron: (rs2282018)
RGD
PMID:28462386
RGD:408364979
NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425
G
Bad
BCL2-associated agonist of cell death
treatment
IDA
RGD
PMID:25447754
RGD:10053709
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823
G
Bax
BCL2 associated X, apoptosis regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17906064
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
G
Bdh1
3-hydroxybutyrate dehydrogenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr11:82,806,125...82,848,133
Ensembl chr11:69,302,534...69,337,671
G
Bdkrb2
bradykinin receptor B2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30685357
NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:124,472,566...124,502,497
G
Blvrb
biliverdin reductase B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 1:91,866,258...91,883,921
Ensembl chr 1:82,738,695...82,770,375
G
Bmal1
basic helix-loop-helix ARNT like 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:36602574
NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:167,331,633...167,430,231
G
Bpnt1
3'(2'), 5'-bisphosphate nucleotidase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr13:99,397,127...99,425,056
Ensembl chr13:96,868,580...96,893,503
G
Brd4
bromodomain containing 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,216,446...11,295,539
G
Btd
biotinidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15469856
NCBI chr16:6,863,068...6,894,345
Ensembl chr16:6,862,407...6,940,945
G
C3
complement C3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429
G
Cabp1
calcium binding protein 1
IEP
protein:increased expression:liver
RGD
PMID:21138988
RGD:7241599
NCBI chr12:47,045,914...47,109,614
Ensembl chr12:41,378,897...41,448,927
G
Cadps2
calcium dependent secretion activator 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chr 4:52,746,054...53,275,252
Ensembl chr 4:51,781,053...52,309,829
G
Canx
calnexin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr10:35,124,941...35,157,954
Ensembl chr10:34,625,191...34,656,821
G
Cap1
cyclase associated actin cytoskeleton regulatory protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 5:140,427,265...140,507,678
Ensembl chr 5:135,142,112...135,168,769
G
Car3
carbonic anhydrase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513 PMID:25231249
NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:86,770,420...86,784,280
G
Casp8
caspase 8
treatment
IEP
RGD
PMID:25447754
RGD:10053709
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
G
Cast
calpastatin
IEP
RGD
PMID:16871587
RGD:5683869
NCBI chr 2:5,707,633...5,817,213
Ensembl chr 2:3,973,112...4,082,659
G
Cat
catalase
ISO IEP
CTD Direct Evidence: marker/mechanism protein:decreased expression:liver
CTD RGD
PMID:20623750 PMID:25231249 PMID:21138988
RGD:7241599
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
G
Ccdc80
coiled-coil domain containing 80
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr11:69,191,188...69,224,844
Ensembl chr11:55,685,872...55,719,137
G
Ccl2
C-C motif chemokine ligand 2
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:20623750 PMID:30663942 PMID:21813474
RGD:14995458 , RGD:14995466
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
G
Ccr2
C-C motif chemokine receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750
NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100
G
Ccr5
C-C motif chemokine receptor 5
susceptibility
ISO
acetaminophen
RGD
PMID:24770590
RGD:14401733
NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:123,752,325...123,759,260
G
Cct3
chaperonin containing TCP1 subunit 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 2:176,063,529...176,088,180
Ensembl chr 2:173,765,698...173,790,757
G
Cct5
chaperonin containing TCP1 subunit 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 2:84,302,621...84,313,773
Ensembl chr 2:82,590,630...82,602,930
G
Cdc25b
cell division cycle 25B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 3:138,860,148...138,870,287
Ensembl chr 3:118,407,128...118,417,272
G
Cds1
CDP-diacylglycerol synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr14:7,820,328...7,882,943
Ensembl chr14:7,820,351...7,882,681
G
Cela1
chymotrypsin like elastase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 7:133,651,939...133,665,136
Ensembl chr 7:131,742,002...131,786,285
G
Cfap20
cilia and flagella associated protein 20
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr19:9,614,265...9,628,612
Ensembl chr19:9,608,859...9,622,558
G
Cfh
complement factor H
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr13:54,063,079...54,164,523
Ensembl chr13:51,511,828...51,613,838
G
Chrm3
cholinergic receptor, muscarinic 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20197374
NCBI chr17:64,696,549...65,158,622
Ensembl chr17:60,005,202...60,467,278
G
Ckb
creatine kinase B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:130,729,423...130,732,315
G
Clu
clusterin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750
NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315
G
Col14a1
collagen type XIV alpha 1 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 7:88,611,827...88,826,939
Ensembl chr 7:86,722,094...86,937,214
G
Col3a1
collagen type III alpha 1 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16679477
NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547
G
Comt
catechol-O-methyltransferase
IEP
protein:decreased expression:liver
RGD
PMID:21138988
RGD:7241599
NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642
G
Coq9
coenzyme Q9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr19:10,172,943...10,185,960
Ensembl chr19:10,166,951...10,179,949
G
Cp
ceruloplasmin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:102,439,624...102,498,075
G
Cpb2
carboxypeptidase B2
IEP
mRNA,protein:increased expression,increased activity:liver,plasma
RGD
PMID:19386599
RGD:7243112
NCBI chr15:56,967,128...57,015,964
Ensembl chr15:50,557,717...50,606,556
G
Cps1
carbamoyl-phosphate synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:68,614,153...68,737,033
G
Cpt1a
carnitine palmitoyltransferase 1A
IEP
mRNA:decreased expression:liver (rat)
RGD
PMID:28959666
RGD:401794432
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055
G
Crp
C-reactive protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178
G
Csf3
colony stimulating factor 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20005281 PMID:33882750
NCBI chr10:84,157,485...84,159,860
Ensembl chr10:83,661,207...83,663,603
G
Ctnnb1
catenin beta 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:19679878
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
G
Ctse
cathepsin E
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr13:45,644,168...45,666,722
Ensembl chr13:43,092,128...43,114,502
G
Cxcl1
C-X-C motif chemokine ligand 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16118408
NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215
G
Cxcl10
C-X-C motif chemokine ligand 10
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11739529
NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975
G
Cxcl14
C-X-C motif chemokine ligand 14
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:38614205
NCBI chr17:8,323,150...8,331,176
Ensembl chr17:8,317,933...8,324,839
G
Cxcl3
C-X-C motif chemokine ligand 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16118408
NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33814510
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28762043
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33814510
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
G
Cyp27b1
cytochrome P450, family 27, subfamily b, polypeptide 1
ISO
mRNA, protein:decreased expression:kidney (mouse)
RGD
PMID:26476181
RGD:25671412
NCBI chr 7:64,756,626...64,761,570
Ensembl chr 7:62,871,297...62,876,241
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28762043 PMID:33814510
NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:236,762,842...236,799,066
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12963435 PMID:28762043
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
ISO
DNA:hypermethylation:promoter
RGD
PMID:27490558
RGD:14700879
NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
treatment
ISO IEP
CTD Direct Evidence: marker/mechanism associated with Endotoxemia DNA:hypermethylation:promoter
CTD RGD
PMID:12668988 PMID:16770646 PMID:21741958 PMID:28762043 PMID:25681370 PMID:29404441 PMID:27324775 PMID:27490558 PMID:27960551 More...
RGD:14700872 , RGD:14700873 , RGD:14700878 , RGD:14700879 , RGD:14700901
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28762043
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
G
Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750
NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
G
Cyp4a3
cytochrome P450, family 4, subfamily a, polypeptide 3
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 5:134,334,396...134,352,268
Ensembl chr 5:129,097,926...129,115,463
G
Cyp8b1
cytochrome P450 family 8 subfamily B member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25448281
NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:121,557,062...121,580,166
G
Dbt
dihydrolipoamide branched chain transacylase E2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 2:207,166,660...207,195,528
Ensembl chr 2:204,481,737...204,510,609
G
Ddb1
damage-specific DNA binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 1:216,677,810...216,703,605
Ensembl chr 1:207,252,890...207,278,676
G
Dgat2
diacylglycerol O-acyltransferase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17984051
NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:153,454,080...153,484,428
G
Dhfr
dihydrofolate reductase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19648163
NCBI chr 2:25,320,895...25,346,004
Ensembl chr 2:23,586,031...23,613,713
G
Dhrs7
dehydrogenase/reductase 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 6:97,068,149...97,083,744
Ensembl chr 6:91,251,323...91,347,892
G
Dlat
dihydrolipoamide S-acetyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:50,978,051...51,004,479 Ensembl chr 1:50,978,051...51,004,479
G
Dnajb9
DnaJ heat shock protein family (Hsp40) member B9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:61,269,913...61,275,063
G
Dnajc12
DnaJ heat shock protein family (Hsp40) member C12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chr20:25,245,475...25,266,238
Ensembl chr20:25,223,144...25,267,521
G
Dsc2
desmocollin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr18:11,725,466...11,757,591
Ensembl chr18:11,450,390...11,482,392
G
E2f1
E2F transcription factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30515189
NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361
G
Echdc1
ethylmalonyl-CoA decarboxylase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 1:28,476,354...28,507,173
Ensembl chr 1:28,476,200...28,507,319
G
Echs1
enoyl-CoA hydratase, short chain 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:194,895,036...194,903,884
G
Edem1
ER degradation enhancing alpha-mannosidase like protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 4:143,350,989...143,385,693
Ensembl chr 4:141,797,701...141,829,717
G
Eif2ak1
eukaryotic translation initiation factor 2 alpha kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25411909
NCBI chr12:15,824,431...15,858,266
Ensembl chr12:10,705,874...10,744,573
G
Eif4ebp2
eukaryotic translation initiation factor 4E binding protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr20:29,922,260...29,942,922
Ensembl chr20:29,382,668...29,399,946
G
Endog
endonuclease G
IEP
protein:decreased expression:mitochondrion:
RGD
PMID:22509279
RGD:9685364
NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:13,449,086...13,451,932
G
Eng
endoglin
IEP
protein:increased expression:liver (rat)
RGD
PMID:21146604
RGD:7257529
NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:15,934,518...15,973,230
G
Eno1
enolase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942 PMID:25231249
NCBI chr 5:166,002,867...166,014,252
Ensembl chr 5:160,719,951...160,731,336 Ensembl chr 3:160,719,951...160,731,336
G
Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
IEP
protein:increased activity:serum:
RGD
PMID:17850827
RGD:9685426
NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:86,202,350...86,324,827
G
Ephx1
epoxide hydrolase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr13:95,246,079...95,275,852
Ensembl chr13:92,714,315...92,790,235
G
Erlec1
endoplasmic reticulum lectin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chr14:108,856,661...108,894,511
Ensembl chr14:104,655,673...104,693,480
G
Ern1
endoplasmic reticulum to nucleus signaling 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30538632
NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029
G
F13a1
coagulation factor XIII A1 chain
ISO
RGD
PMID:22019897
RGD:11041813
NCBI chr17:28,021,197...28,197,960
Ensembl chr17:27,815,702...27,992,700
G
F2rl3
F2R like thrombin or trypsin receptor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20974703
NCBI chr16:17,151,516...17,153,509
Ensembl chr16:17,117,441...17,119,472
G
F3
coagulation factor III, tissue factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22407844
NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668
G
Fadd
Fas associated via death domain
treatment
IEP
RGD
PMID:26062544 PMID:25447754
RGD:11341803 , RGD:10053709
NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:199,739,994...199,745,653
G
Fads1
fatty acid desaturase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 1:216,252,605...216,267,618
Ensembl chr 1:206,827,765...206,842,734
G
Fads2
fatty acid desaturase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 1:216,132,277...216,172,190
Ensembl chr 1:206,708,783...206,748,789
G
Fas
Fas cell surface death receptor
IEP
protein:increased expression:liver (rat)
RGD
PMID:16831245
RGD:8662853
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
G
Fasn
fatty acid synthase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
G
Fcmr
Fc mu receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr13:44,889,628...44,903,926
Ensembl chr13:42,337,414...42,351,653
G
Fga
fibrinogen alpha chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20974703
NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:168,374,120...168,381,528
G
Fgf21
fibroblast growth factor 21
severity
IEP
mRNA:increased expression:liver (rat)
RGD
PMID:29883717
RGD:15045603
NCBI chr 1:105,219,825...105,221,376
Ensembl chr 1:96,083,441...96,090,454
G
Flt1
Fms related receptor tyrosine kinase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21135413
NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626
G
Fmo3
flavin containing dimethylaniline monoxygenase 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24973094
NCBI chr13:77,838,899...77,868,869
Ensembl chr13:75,309,374...75,328,028
G
Ftl1
ferritin light chain 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 1:105,072,858...105,074,705
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725 Ensembl chr 2:95,936,387...95,939,725
G
G6pc1
glucose-6-phosphatase catalytic subunit 1
ISO
mRNA:decreased expression:liver (mouse)
RGD
PMID:28189721
RGD:14695531
NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,257,668...86,333,804
G
G6pd
glucose-6-phosphate dehydrogenase
treatment
IEP
RGD
PMID:21864513
RGD:10449168
NCBI chr X:157,352,364...157,372,144
Ensembl chr X:152,201,098...152,220,801
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750
NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115
G
Ganab
glucosidase II alpha subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 1:205,793,910...205,813,704
Ensembl chr 1:205,793,895...205,813,695
G
Gc
GC, vitamin D binding protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chr14:18,916,255...18,951,670
Ensembl chr14:18,632,135...18,667,567
G
Gclc
glutamate-cysteine ligase, catalytic subunit
IMP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:19481141 PMID:17573345
RGD:10402383
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
G
Gda
guanine deaminase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 1:228,333,401...228,408,901
Ensembl chr 1:218,906,815...218,982,416
G
Gdi1
GDP dissociation inhibitor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr X:157,238,900...157,245,562
Ensembl chr X:152,087,444...152,094,272
G
Gfer
growth factor, augmenter of liver regeneration
treatment
ISO IDA
RGD
PMID:22033404 PMID:15968720
RGD:9685722 , RGD:9685727
NCBI chr10:14,223,023...14,225,736
Ensembl chr10:13,718,489...13,720,869
G
Ggh
gamma-glutamyl hydrolase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21219404
NCBI chr 5:38,326,747...38,349,655
Ensembl chr 5:33,529,880...33,552,787
G
Ggt1
gamma-glutamyltransferase 1
IEP
RGD
PMID:10934156
RGD:14701049
NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442
G
Ghrl
ghrelin and obestatin prepropeptide
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:34151639
NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:146,865,712...146,869,621
G
Glud1
glutamate dehydrogenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33483742
NCBI chr16:9,646,569...9,680,215
Ensembl chr16:9,640,312...9,673,957
G
Got1
glutamic-oxaloacetic transaminase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633
G
Gpd1
glycerol-3-phosphate dehydrogenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 7:132,722,982...132,730,373
Ensembl chr 7:130,844,138...130,851,529
G
Gpt
glutamic--pyruvic transaminase
treatment
ISO IEP
CTD Direct Evidence: marker/mechanism protein:increased expression, activity:serum:
CTD RGD
PMID:145039 PMID:19481104 PMID:28487901 PMID:21772750 PMID:27293452 PMID:19085960 PMID:19085960 More...
RGD:14975162 , RGD:14975166 , RGD:14975168 , RGD:14975249 , RGD:14975249
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
G
Gpt2
glutamic--pyruvic transaminase 2
IEP ISO
protein:increased expression, activity:serum:
RGD
PMID:19085960 PMID:19085960
RGD:14975249 , RGD:14975249
NCBI chr19:37,700,023...37,734,551
Ensembl chr19:21,517,621...21,560,610
G
Grk4
G protein-coupled receptor kinase 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr14:80,230,699...80,305,292
Ensembl chr14:76,006,218...76,080,693
G
Gsn
gelsolin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:18,585,172...18,638,402
G
Gsr
glutathione-disulfide reductase
treatment
IEP ISO
mRNA, protein:increased expression:liver CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:25226513 PMID:28069987 PMID:23554813 PMID:24154663
RGD:7257532 , RGD:10401878
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
G
Gsta1
glutathione S-transferase alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28412881
NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:23,703,477...23,720,121
G
Gsta4
glutathione S-transferase alpha 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:79,066,934...79,084,182
G
Gstm1
glutathione S-transferase mu 1
no_association
ISO IEP
CTD Direct Evidence: marker/mechanism protein:increased expression:liver
CTD RGD
PMID:17465707 PMID:18666253 PMID:21138988 PMID:29523098 PMID:24903797 PMID:24465778 PMID:25501156 More...
RGD:7241599 , RGD:14700937 , RGD:14700941 , RGD:14700959 , RGD:14700970
NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411
G
Gstm2
glutathione S-transferase mu 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750
NCBI chr 2:198,312,179...198,316,962
Ensembl chr 2:195,544,426...195,628,961
G
Gstm4
glutathione S-transferase mu 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 2:198,356,114...198,373,487
Ensembl chr 2:195,680,004...195,685,323
G
Gstm5
glutathione S-transferase, mu 5
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:25743375
NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:195,531,495...195,534,553
G
Gsto1
glutathione S-transferase omega 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 1:256,662,377...256,672,515
Ensembl chr 1:246,721,221...246,731,468
G
Gstp1
glutathione S-transferase pi 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750 PMID:25226513
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
G
Gstt1
glutathione S-transferase theta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18397238 PMID:18666253 PMID:25226513
NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,669...12,873,585
G
H19
H19 imprinted maternally expressed transcript
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30515189
NCBI chr 1:207,160,175...207,162,851
Ensembl chr 1:197,730,698...197,733,134
G
H2ax
H2A.X variant histone
treatment
IDA
RGD
PMID:23265463
RGD:8693741
NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
G
Hacl1
2-hydroxyacyl-CoA lyase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chr16:6,831,293...6,869,410
Ensembl chr16:6,824,906...6,863,027
G
Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:26,187,956...26,227,869
G
Hamp
hepcidin antimicrobial peptide
IEP
mRNA:increased expression:hepatocyte
RGD
PMID:24373749
RGD:11041724
NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:86,170,901...86,172,891
G
Hao2
hydroxyacid oxidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 2:188,888,848...188,921,567
Ensembl chr 2:186,200,504...186,224,425
G
Havcr1
hepatitis A virus cellular receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750
NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698
G
Hba-a1
hemoglobin alpha, adult chain 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr10:15,841,724...15,842,580
Ensembl chr10:15,307,815...15,338,392
G
Hmgb1
high mobility group box 1
treatment
ISO IEP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:19783637 PMID:29091898
RGD:15090820
NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
G
Hmox1
heme oxygenase 1
treatment
IEP ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD RGD
PMID:18227147 PMID:22688006 PMID:22886620 PMID:29091898
RGD:10762620 , RGD:15090820
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
G
Hpd
4-hydroxyphenylpyruvate dioxygenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942 PMID:22872058
NCBI chr12:39,042,246...39,053,596
Ensembl chr12:33,381,231...33,392,766
G
Hprt1
hypoxanthine phosphoribosyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr X:137,655,744...137,687,718
Ensembl chr X:132,736,096...132,768,154
G
Hpx
hemopexin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:159,932,755...159,940,328
G
Hrh2
histamine receptor H 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22926047
NCBI chr17:10,371,083...10,412,979
Ensembl chr17:10,368,298...10,407,631
G
Hspa5
heat shock protein family A (Hsp70) member 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
G
Hspa8
heat shock protein family A (Hsp70) member 8
IEP
protein:altered localization:liver (rat)
RGD
PMID:12376827
RGD:10059389
NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259
G
Icam1
intercellular adhesion molecule 1
treatment
IEP
RGD
PMID:29091898
RGD:15090820
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
G
Idh2
isocitrate dehydrogenase (NADP(+)) 2
severity
ISO
RGD
PMID:31121248
RGD:14985250
NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:134,029,772...134,058,025
G
Ido2
indoleamine 2,3-dioxygenase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32289347
NCBI chr16:74,161,761...74,200,651
Ensembl chr16:67,459,190...67,496,324
G
Ifng
interferon gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12153990 PMID:21245496 PMID:30013034
RGD:14975100
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
G
Igf1
insulin-like growth factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23639586 PMID:25226513
NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296
G
Il11
interleukin 11
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11421492
NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:69,068,137...69,076,129
G
Il12b
interleukin 12B
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:36520315
NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
G
Il17a
interleukin 17A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19633216 PMID:24949944
NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889
G
Il18
interleukin 18
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19164858
NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887
G
Il1a
interleukin 1 alpha
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:8218930
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
G
Il1b
interleukin 1 beta
treatment
IDA ISO IEP
CTD Direct Evidence: marker/mechanism|therapeutic
CTD RGD
PMID:19164858 PMID:28138970 PMID:23102243 PMID:29278859 PMID:31077717 PMID:31342809 PMID:29091898 More...
RGD:7204421 , RGD:13793380 , RGD:14975281 , RGD:15036799 , RGD:15090820
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
G
Il1r2
interleukin 1 receptor type 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17984051
NCBI chr 9:49,879,928...49,920,374
Ensembl chr 9:42,384,433...42,424,725
G
Il22
interleukin 22
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:15122762 PMID:16212920 PMID:23375450
NCBI chr 7:55,687,061...55,691,526
Ensembl chr 7:53,801,206...53,806,186
G
Il4
interleukin 4
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:21094227 PMID:21735453 PMID:22107450
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
G
Il6
interleukin 6
treatment
ISO IEP
CTD Direct Evidence: therapeutic
CTD RGD
PMID:7532385 PMID:15763341 PMID:29091898
RGD:15090820
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
G
Immt
inner membrane mitochondrial protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 4:105,438,657...105,477,370
Ensembl chr 4:103,880,459...103,919,109
G
Irak1
interleukin-1 receptor-associated kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr X:156,919,927...156,929,825
Ensembl chr X:151,768,777...151,778,521
G
Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491
G
Jund
JunD proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30515189
NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,734,122...18,735,799
G
Keap1
Kelch-like ECH-associated protein 1
ISO
RGD
PMID:18417483
RGD:6893370
NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862
G
Kitlg
KIT ligand
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12594235
NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:34,896,053...34,977,214
G
Kng1
kininogen 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20362651 PMID:30685357
NCBI chr11:91,317,354...91,340,148
Ensembl chr11:77,812,752...77,835,555
G
Krt18
keratin 18
ISO
mRNA, protein:increased expression:liver (mouse) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:19783637 PMID:33483742 PMID:38521541 PMID:17340120
RGD:18337498
NCBI chr 7:135,036,168...135,039,844
Ensembl chr 7:133,157,475...133,161,166 Ensembl chr10:133,157,475...133,161,166
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Krt8
keratin 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:133,124,203...133,131,728
G
Lap3
leucine aminopeptidase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr14:69,820,907...69,839,891
Ensembl chr14:65,608,376...65,627,359
G
Lbp
lipopolysaccharide binding protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:146,954,015...146,981,586
G
Lcat
lecithin cholesterol acyltransferase
IEP
mRNA:decreased expression:liver (rat)
RGD
PMID:28959666
RGD:401794432
NCBI chr19:50,744,598...50,748,064
Ensembl chr19:33,834,403...33,838,231
G
Lcn2
lipocalin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20362651 PMID:20623750
NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095
G
Ldlr
low density lipoprotein receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:36108984
NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580
G
Lgals3
galectin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22461450
NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025
G
Lipc
lipase C, hepatic type
IEP
mRNA:decreased expression:liver (rat)
RGD
PMID:28959666
RGD:401794432
NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:71,509,635...71,635,464
G
Lpl
lipoprotein lipase
treatment
IEP
RGD
PMID:27071702
RGD:13794380
NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249
G
Lrat
lecithin retinol acyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 2:170,562,148...170,571,212
Ensembl chr 2:168,266,877...168,273,619
G
Ltb4r
leukotriene B4 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28487374
NCBI chr15:33,233,120...33,235,636
G
Ltf
lactotransferrin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16141546
NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:110,999,948...111,022,795
G
Map1lc3b
microtubule-associated protein 1 light chain 3 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
G
Map3k5
mitogen-activated protein kinase kinase kinase 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18700144
NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:14,685,492...14,904,800
G
Mat1a
methionine adenosyltransferase 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr16:17,017,168...17,035,368
Ensembl chr16:16,983,022...17,001,274
G
Mccc1
methylcrotonyl-CoA carboxylase subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 2:120,727,313...120,779,334
Ensembl chr 2:118,799,150...118,851,222
G
Mdh1
malate dehydrogenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chr14:99,831,934...99,847,227
Ensembl chr14:95,630,306...95,645,925
G
Me1
malic enzyme 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:87,549,043...87,660,304
G
Med1
mediator complex subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16109766
NCBI chr10:83,641,851...83,685,560
Ensembl chr10:83,145,568...83,189,299
G
Mir100
microRNA 100
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr 8:50,798,295...50,798,374
Ensembl chr 8:41,901,225...41,901,304
G
Mir103a1
microRNA 103a-1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr10:20,748,474...20,748,559
Ensembl chr10:20,244,412...20,244,497
G
Mir106b
microRNA 106b
IEP IDA
miRNA:decreased expression:liver (rat) DNA:hypermethylation:promoter
RGD
PMID:29554950 PMID:29554950
RGD:15042854 , RGD:15042854
NCBI chr12:22,157,053...22,157,134
Ensembl chr12:17,043,344...17,043,425
G
Mir107
microRNA 107
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25359176 PMID:28545106
NCBI chr 1:241,750,418...241,750,504
Ensembl chr 1:232,337,767...232,337,853
G
Mir10a
microRNA 10a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr10:81,779,709...81,779,818
Ensembl chr10:81,283,171...81,283,280
G
Mir10b
microRNA 10b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 3:80,035,859...80,035,967
Ensembl chr 3:59,628,438...59,628,546
G
Mir122
microRNA 122
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22045675 PMID:22363424 PMID:25359176 PMID:25527335 PMID:26489516 PMID:28545106 PMID:28844483 PMID:33483742 More...
NCBI chr18:61,028,817...61,028,901
G
Mir1249
microRNA 1249
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr 7:116,075,593...116,075,712
Ensembl chr 7:116,075,593...116,075,712
G
Mir125b1
microRNA 125b-1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr 8:50,850,036...50,850,122
Ensembl chr 8:41,952,966...41,953,052
G
Mir125b2
microRNA 125b-2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr11:29,732,572...29,732,659
G
Mir1306
microRNA 1306
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr11:96,213,960...96,214,032
Ensembl chr11:82,709,637...82,709,719
G
Mir130a
microRNA 130a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25359176 PMID:28545106
NCBI chr 3:90,229,228...90,229,315
Ensembl chr 3:69,822,542...69,822,629
G
Mir130b
microRNA 130b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr11:97,384,380...97,384,461
Ensembl chr11:83,880,163...83,880,244
G
Mir132
microRNA 132
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr10:60,522,033...60,522,133
Ensembl chr10:60,023,696...60,023,796
G
Mir141
microRNA 141
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424 PMID:28545106
NCBI chr 4:159,209,525...159,209,618
Ensembl chr 4:157,523,239...157,523,332
G
Mir142
microRNA 142
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr10:73,055,104...73,055,190
Ensembl chr10:72,557,857...72,557,967
G
Mir143
microRNA 143
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30125006
NCBI chr18:57,371,349...57,371,453
Ensembl chr18:55,101,006...55,101,110
G
Mir148a
microRNA 148a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25359176 PMID:28545106
NCBI chr 4:81,664,431...81,664,527
Ensembl chr 4:80,333,762...80,333,858
G
Mir150
microRNA 150
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr 1:104,741,487...104,741,571
Ensembl chr 1:95,605,024...95,605,108
G
Mir151b
microRNA 151b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr 7:105,172,377...105,172,496
Ensembl chr 7:105,172,377...105,172,496
G
Mir152
microRNA 152
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr10:82,329,383...82,329,467
Ensembl chr10:81,832,936...81,833,020
G
Mir155
microRNA 155
treatment
ISO
RGD
PMID:29420849 PMID:27673475 PMID:26867493
RGD:21409750 , RGD:25671463 , RGD:25671474
NCBI chr11:37,261,114...37,261,178
Ensembl chr11:23,774,654...23,774,718
G
Mir17
microRNA 17
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr15:98,587,848...98,587,931
Ensembl chr15:92,180,629...92,180,712
G
Mir181c
microRNA 181c
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr19:40,888,291...40,888,396
Ensembl chr19:23,983,523...23,983,628
G
Mir188
microRNA 188
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr X:17,919,585...17,919,664
Ensembl chr X:15,247,715...15,247,794
G
Mir18a
microRNA 18a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr15:98,587,984...98,588,079
Ensembl chr15:92,180,765...92,180,860
G
Mir191
microRNA 191
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr 8:118,142,627...118,142,717
G
Mir192
microRNA 192
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22045675 PMID:25359176 PMID:28483554 PMID:28545106
NCBI chr 1:203,564,946...203,565,055
Ensembl chr 1:203,564,946...203,565,055
G
Mir193a
microRNA 193a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr10:65,170,306...65,170,417
Ensembl chr10:64,672,343...64,672,454
G
Mir193b
microRNA 193b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr10:1,317,742...1,317,824
Ensembl chr10:1,317,742...1,317,824
G
Mir194-1
microRNA 194-1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28844483
NCBI chr13:99,382,716...99,382,798
Ensembl chr13:96,851,166...96,851,248
G
Mir19a
microRNA 19a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr15:98,588,131...98,588,212
Ensembl chr15:92,180,912...92,180,993
G
Mir1a-1
microRNA 1a-1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30125006
NCBI chr 3:167,487,117...167,487,201
Ensembl chr 3:167,487,117...167,487,201
G
Mir200c
microRNA 200c
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 4:159,209,965...159,210,033
G
Mir203-2
microRNA 203-2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:32659284
NCBI chr 6:131,199,542...131,199,656
Ensembl chr 6:131,199,542...131,199,656
G
Mir21
microRNA 21
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348
G
Mir210
microRNA 210
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr 1:205,755,923...205,756,032
Ensembl chr 1:196,326,337...196,326,454
G
Mir217
microRNA 217
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr14:106,732,485...106,732,589
Ensembl chr14:102,531,505...102,531,609
G
Mir22
microRNA 22
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25359176 PMID:28545106
NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,307,039...60,307,133
G
Mir221
microRNA 221
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr X:6,023,182...6,023,290
Ensembl chr X:3,429,465...3,429,573
G
Mir222
microRNA 222
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr X:6,022,621...6,022,723
Ensembl chr X:3,428,904...3,429,006
G
Mir223
microRNA 223
ISO
RNA:increased expression:serum,liver
RGD
PMID:28646120
RGD:21408574
NCBI chr X:65,151,383...65,151,492
Ensembl chr X:61,141,887...61,141,996
G
Mir23a
microRNA 23a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr19:40,859,769...40,859,843
Ensembl chr19:23,954,997...23,955,071
G
Mir23b
microRNA 23b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr17:1,819,386...1,819,482
Ensembl chr17:1,813,667...1,813,763
G
Mir27b
microRNA 27b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25359176 PMID:28545106
NCBI chr17:1,819,147...1,819,243
Ensembl chr17:1,813,426...1,813,529
G
Mir29b2
microRNA 29b-2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr13:109,098,831...109,098,911
Ensembl chr13:106,570,367...106,570,456
G
Mir301a
microRNA 301a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr10:72,422,599...72,422,698
Ensembl chr10:71,925,336...71,925,435
G
Mir30a
microRNA 30a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424 PMID:25359176 PMID:28545106
NCBI chr 9:33,233,941...33,234,011
Ensembl chr 9:25,737,600...25,737,670
G
Mir30b
microRNA 30b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr 7:102,021,543...102,021,629
Ensembl chr 7:100,132,589...100,132,675
G
Mir30c1
microRNA 30c-1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 5:139,634,455...139,634,543
Ensembl chr 5:134,349,237...134,349,325
G
Mir320a
microRNA 320a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106 PMID:30125006
NCBI chr15:51,926,088...51,926,169
Ensembl chr15:45,516,392...45,516,473
G
Mir328
microRNA 328
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr19:50,094,691...50,094,774
Ensembl chr19:33,184,766...33,184,849
G
Mir337
microRNA 337
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 6:134,321,142...134,321,238
Ensembl chr 6:128,538,902...128,538,998
G
Mir342
microRNA 342
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr 6:133,329,655...133,329,753
Ensembl chr 6:127,565,269...127,565,367
G
Mir345
microRNA 345
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr 6:133,518,403...133,518,498
Ensembl chr 6:127,754,027...127,754,122
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Mir34a
microRNA 34a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr 5:165,815,952...165,816,053
Ensembl chr 5:160,533,002...160,533,103
G
Mir34c
microRNA 34c
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 8:60,306,091...60,306,167
Ensembl chr 8:51,409,726...51,409,802
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Mir361
microRNA 361
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr X:82,438,463...82,438,532
Ensembl chr X:78,246,206...78,246,275
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Mir410
microRNA 410
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 6:134,579,763...134,579,838
Ensembl chr 6:128,758,354...128,758,434
G
Mir423
microRNA 423
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr10:62,412,272...62,412,350
Ensembl chr10:61,914,133...61,914,226
G
Mir455
microRNA 455
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr 5:81,704,834...81,704,911
Ensembl chr 5:76,689,313...76,689,390
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Mir484
microRNA 484
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr10:1,394,905...1,394,981
Ensembl chr10:887,684...887,760
G
Mir497
microRNA 497
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr10:55,450,171...55,450,239
Ensembl chr10:54,951,505...54,951,584
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Mir499a
microRNA 499a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr 3:144,110,469...144,110,533
Ensembl chr 3:144,110,469...144,110,533
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Mir503
microRNA 503
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr X:137,725,856...137,725,926
Ensembl chr X:132,806,303...132,806,373
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Mir532
microRNA 532
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr X:17,919,185...17,919,263
Ensembl chr X:15,247,315...15,247,393
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Mir592
microRNA 592
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424 PMID:28545106
NCBI chr 4:56,505,280...56,505,375
Ensembl chr 4:56,505,280...56,505,375
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Mir764
microRNA 764
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr X:110,678,597...110,678,704
Ensembl chr X:110,678,597...110,678,704
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Mir877
microRNA 877
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27713024
NCBI chr20:2,816,284...2,816,368
Ensembl chr20:2,811,476...2,811,560
G
Mir93
microRNA 93
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr12:22,156,844...22,156,930
Ensembl chr12:17,043,135...17,043,221
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Mir99a
microRNA 99a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr11:29,687,392...29,687,472
Ensembl chr11:16,200,443...16,200,523
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Mirlet7b
microRNA let-7b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106 PMID:30125006
NCBI chr 7:118,684,038...118,684,122
Ensembl chr 7:116,804,186...116,804,270
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Mirlet7c1
microRNA let-7c-1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr11:29,688,112...29,688,205
Ensembl chr11:16,201,158...16,201,265
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Mirlet7d
microRNA let-7d
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr17:16,322,260...16,322,357
Ensembl chr17:16,115,893...16,115,990
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Mirlet7g
microRNA let-7g
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr 8:115,701,020...115,701,107
Ensembl chr 8:106,822,280...106,822,388
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Mirlet7i
microRNA let-7i
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr 7:60,527,877...60,527,961
Ensembl chr 7:58,642,480...58,642,571
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Mmp2
matrix metallopeptidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15763341
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22507835
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
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Mst1
macrophage stimulating 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 8:117,646,485...117,652,016
Ensembl chr 8:108,768,839...108,773,416
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Mst1r
macrophage stimulating 1 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22575169
NCBI chr 8:117,471,928...117,491,059
Ensembl chr 8:108,597,299...108,612,455
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Mt-nd6
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6
IEP
mRNA:decreased expression:blood
RGD
PMID:20130021
RGD:8657129
NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061
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Mthfr
methylenetetrahydrofolate reductase
treatment
ISO
CTD Direct Evidence: marker/mechanism associated with precursor lymphoblastic lymphoma/leukemia; DNA:SNP: :677C>T(human)
CTD RGD
PMID:18551038 PMID:19648163 PMID:30545275
RGD:14696733
NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797
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Mtpn
myotrophin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 4:65,126,390...65,153,803
Ensembl chr 4:64,157,641...64,186,724
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Mug2
murinoglobulin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chr 4:156,836,140...156,908,972
Ensembl chr 4:155,164,011...155,236,475
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Myd88
MYD88, innate immune signal transduction adaptor
ameliorates
ISO
RGD
PMID:17615358
RGD:150521532
NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415
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Nat2
N-acetyltransferase 2
treatment
ISO
associated with Tuberculosis;DNA:haplotype: : CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:11915035 PMID:16799928 PMID:17950035 PMID:25693865 PMID:18023090
RGD:8552665
NCBI chr16:26,974,874...27,005,191
Ensembl chr16:22,208,194...22,238,520
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Ndufs3
NADH:ubiquinone oxidoreductase core subunit S3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 3:97,332,477...97,339,654
Ensembl chr 3:76,876,646...76,883,824
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Nfatc4
nuclear factor of activated T-cells 4
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:34192554
NCBI chr15:33,256,912...33,284,522
Ensembl chr15:29,305,535...29,314,610
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Nfe2l2
NFE2 like bZIP transcription factor 2
treatment
ISO IEP
CTD Direct Evidence: therapeutic induced by methotrexate (CHEBI:44185), treated by ferulic acid (CHEBI:17620)
CTD RGD
PMID:22491424 PMID:22627062 PMID:24813929 PMID:26958860 PMID:30215777 PMID:18417483 PMID:29091898 PMID:31972209 PMID:32066295 PMID:31927046 PMID:31889292 More...
RGD:6893370 , RGD:15090820 , RGD:21201280 , RGD:21201283 , RGD:21201305 , RGD:21201308
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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Nfkb1
nuclear factor kappa B subunit 1
treatment susceptibility
IEP ISO
associated with tuberculosis ;DNA:SNPs,haplotypes: 3'utr,5'utr: (rs78872571,rs4647992) (human)
RGD
PMID:29091898 PMID:31490979
RGD:15090820 , RGD:40902984
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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Nfxl1
nuclear transcription factor, X-box binding-like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chr14:35,626,086...35,667,505
Ensembl chr14:35,626,066...35,667,498
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Nme2
NME/NM23 nucleoside diphosphate kinase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr10:79,394,999...79,400,418
Ensembl chr10:78,897,770...78,903,538 Ensembl chr20:78,897,770...78,903,538
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Notch1
notch receptor 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:30394310
NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531
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Nox4
NADPH oxidase 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406
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Nqo1
NAD(P)H quinone dehydrogenase 1
treatment
IDA ISO IEP
RGD
PMID:28522909 PMID:28472605 PMID:29091898
RGD:13439737 , RGD:13439739 , RGD:15090820
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29943110
NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609
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Nr1d1
nuclear receptor subfamily 1, group D, member 1
treatment
ISO
RGD
PMID:24497272
RGD:10448995
NCBI chr10:84,224,599...84,231,812
Ensembl chr10:83,728,318...83,735,705
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Nr1h3
nuclear receptor subfamily 1, group H, member 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17256725
NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:77,158,808...77,168,722
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
treatment severity
ISO IEP
CTD Direct Evidence: marker/mechanism protein:decreased expression:liver (rat) mRNA:decreased expression:liver (rat)
CTD RGD
PMID:12875239 PMID:20573685 PMID:22711662 PMID:30068870 PMID:28827769 PMID:29091898 More...
RGD:14701035 , RGD:14701036 , RGD:15042870 , RGD:15045609 , RGD:15090820
NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:23,846,122...23,942,047
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
susceptibility
ISO
CTD Direct Evidence: marker/mechanism|therapeutic associated with tuberculosis ;DNA:SNP,haplotypes:promoter: (rs3814055) (human)
CTD RGD
PMID:19797606 PMID:28058446 PMID:31490979
RGD:40902984
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:14742670 PMID:25656644 PMID:28058446
NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906
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Nr2f2
nuclear receptor subfamily 2, group F, member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 1:133,419,161...133,434,290
Ensembl chr 1:124,009,181...124,022,031
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Nr5a2
nuclear receptor subfamily 5, group A, member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29515023
NCBI chr13:50,865,253...50,985,107
Ensembl chr13:48,316,301...48,433,326
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Nrep
neuronal regeneration related protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,017,083...25,046,591
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Ntn1
netrin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:35292334
NCBI chr10:53,398,852...53,597,595
Ensembl chr10:52,899,934...53,085,326
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Nus1
NUS1 dehydrodolichyl diphosphate synthase subunit
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:33812996
NCBI chr20:32,354,519...32,381,265
Ensembl chr20:31,811,817...31,838,561
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Obp3
alpha-2u globulin PGCL4
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 5:74,842,316...74,845,858
Ensembl chr 5:74,842,316...74,845,757
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Ociad1
OCIA domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr14:34,897,851...34,915,291
Ensembl chr14:34,897,847...34,915,286
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Ogdh
oxoglutarate dehydrogenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr14:85,363,949...85,431,405
Ensembl chr14:81,150,091...81,217,479
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Olr59
olfactory receptor 59
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 1:166,604,972...166,639,634
Ensembl chr 1:157,193,080...157,211,179
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P4hb
prolyl 4-hydroxylase subunit beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr10:106,335,300...106,346,911
Ensembl chr10:105,836,982...105,848,500
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Pah
phenylalanine hydroxylase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 7:23,793,096...23,885,631
Ensembl chr 7:21,933,179...21,998,130
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Pan2
poly(A) specific ribonuclease subunit PAN2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chr 7:1,313,654...1,332,252
Ensembl chr 7:729,562...747,744
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Panx1
Pannexin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29246445
NCBI chr 8:20,128,783...20,171,200
Ensembl chr 8:11,850,730...11,889,774
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Park7
Parkinsonism associated deglycase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970
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Pc
pyruvate carboxylase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:201,804,267...201,898,380
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Pcolce
procollagen C-endopeptidase enhancer
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr12:24,720,972...24,727,287
Ensembl chr12:19,084,210...19,090,508
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Pcyt1a
phosphate cytidylyltransferase 1A, choline
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr11:68,313,860...68,357,828
Ensembl chr11:68,313,882...68,357,357
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Pdk4
pyruvate dehydrogenase kinase 4
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:21182459 PMID:31809757
NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:33,589,799...33,601,850
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Pdlim5
PDZ and LIM domain 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 2:233,625,478...233,793,582
Ensembl chr 2:230,952,248...231,120,275
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Pex11a
peroxisomal biogenesis factor 11 alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 1:143,089,410...143,096,491
Ensembl chr 1:133,680,091...133,687,172
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Pgm1
phosphoglucomutase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 5:119,710,734...119,770,159
Ensembl chr 5:114,595,293...114,654,728
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Plat
plasminogen activator, tissue type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22507835
NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223
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Plg
plasminogen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22507835
NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:48,325,185...48,367,786
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Pls3
plastin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr X:116,401,247...116,495,898
Ensembl chr X:111,589,254...111,683,891
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Pnp
purine nucleoside phosphorylase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chr15:26,644,147...26,651,808
Ensembl chr15:24,170,602...24,203,986
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Pnrc1
proline-rich nuclear receptor coactivator 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 5:47,647,070...47,657,832
Ensembl chr 5:47,647,071...47,650,161
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Polg
DNA polymerase gamma, catalytic subunit
no_association susceptibility
ISO IAGP
CTD Direct Evidence: marker/mechanism DNA:missense mutations:cds:p.Q1236H, p.E1143G (33708G>T, 3428A>G) (human) DNA:missense mutation:cds:p.W748S, p.E1143G (2243G>C, 3428A>G) (human)
CTD RGD
PMID:18208989 PMID:20138553 PMID:30255931 PMID:25065347
RGD:15039297 , RGD:15039302
NCBI chr 1:142,792,119...142,808,933
Ensembl chr 1:133,382,766...133,398,567
G
Polr2g
RNA polymerase II subunit G
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 1:215,118,278...215,125,389
Ensembl chr 1:205,689,160...205,692,686
G
Pon1
paraoxonase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:33,294,722...33,321,360
G
Ppara
peroxisome proliferator activated receptor alpha
ISO
LPS-induced acute liver damage CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:24385052 PMID:38181850 PMID:21262334
RGD:5509941
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
G
Pparg
peroxisome proliferator-activated receptor gamma
ISO
mRNA, protein:decreased expression:liver
RGD
PMID:26599535
RGD:11554658
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
G
Pptc7
protein phosphatase targeting COQ7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr12:39,910,728...39,949,101
Ensembl chr12:34,249,977...34,288,339
G
Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
treatment
IEP
RGD
PMID:29091898
RGD:15090820
NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978
G
Prkcd
protein kinase C, delta
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:30393195
NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352
G
Prkdc
protein kinase, DNA-activated, catalytic subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21224054
NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952
G
Ptf1a
pancreas associated transcription factor 1a
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21182459
NCBI chr17:86,959,621...86,961,475
Ensembl chr17:82,051,281...82,053,135
G
Ptges2
prostaglandin E synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:31444509
NCBI chr 3:36,088,246...36,095,430
Ensembl chr 3:15,690,501...15,697,688
G
Ptgs2
prostaglandin-endoperoxide synthase 2
treatment
ISO IEP
CTD Direct Evidence: therapeutic
CTD RGD
PMID:11743745 PMID:29091898
RGD:15090820
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
G
Pum1
pumilio RNA-binding family member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 5:148,120,712...148,238,468
Ensembl chr 5:142,837,127...142,954,039
G
Pygl
glycogen phosphorylase L
ISO IEP
CTD Direct Evidence: marker/mechanism protein:increased expression:serum (rat)
CTD RGD
PMID:25231249 PMID:25336395
RGD:21079733
NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:88,697,593...88,740,310
G
Rasa1
RAS p21 protein activator 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 2:17,593,136...17,676,707
Ensembl chr 2:15,857,980...15,940,854
G
Rbp1
retinol binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chr 8:107,904,589...107,926,109
Ensembl chr 8:99,025,206...99,046,743
G
Rdh13
retinol dehydrogenase 13
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27865848
NCBI chr 1:78,415,765...78,444,116
Ensembl chr 1:69,373,113...69,400,908
G
Reep5
receptor accessory protein 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chr18:26,219,528...26,257,505
Ensembl chr18:25,945,381...25,976,509
G
Rgn
regucalcin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr X:4,172,537...4,190,112
Ensembl chr X:1,619,032...1,634,450
G
Ripk3
receptor-interacting serine-threonine kinase 3
ISO
CTD Direct Evidence: therapeutic protein:increased expression:liver (mouse)
CTD RGD
PMID:26769846 PMID:28205631
RGD:127229945
NCBI chr15:33,253,071...33,262,025
Ensembl chr15:29,283,145...29,292,121
G
RT1-Ba
RT1 class II, locus Ba
susceptibility
ISO
DNA:polymorphism: :HLA-DQA1*0102(human) associated with tuberculosis;DNA:polymorphism: :HLA-DQA1*0102(human)
RGD
PMID:20639878 PMID:12359646
RGD:14398844 , RGD:14401573
NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,575,134...4,579,744
G
RT1-Bb
RT1 class II, locus Bb
susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:polymorphism, haplotype DNA:polymorphism: :HLA-DQB1*05(human)
CTD RGD
PMID:21570397 PMID:26959717 PMID:25250564
RGD:11573514 , RGD:36174016
NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,596,559...4,607,597
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RT1-CE16
RT1 class I, locus CE16
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21570397 PMID:28043905
NCBI chr20:3,261,656...3,265,548
Ensembl chr20:3,257,123...3,279,563
G
RT1-Db1
RT1 class II, locus Db1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21570397
NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,548,666...4,558,258
G
S100a11
S100 calcium binding protein A11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 2:181,875,132...181,880,542
Ensembl chr 2:179,191,715...179,197,044
G
Scarb1
scavenger receptor class B, member 1
IEP
mRNA:increased expression:liver (rat)
RGD
PMID:28959666
RGD:401794432
NCBI chr12:36,957,302...37,023,982
Ensembl chr12:31,296,156...31,362,647
G
Selenbp1
selenium binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750
NCBI chr 2:185,183,022...185,193,612
Ensembl chr 2:182,493,978...182,504,594
G
Sema3a
semaphorin 3A
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:33290778
NCBI chr 4:22,239,418...22,709,907
Ensembl chr 4:21,287,982...21,494,432
G
Sema4a
semaphorin 4A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33290778
NCBI chr 2:176,194,248...176,215,752
Ensembl chr 2:173,896,439...173,914,442
G
Senp2
SUMO specific peptidase 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29535048
NCBI chr11:92,487,259...92,522,795
Ensembl chr11:78,981,432...79,018,238
G
Serpina1
serpin family A member 1
susceptibility
IEP ISO
protein:decreased expression:plasma DNA:missense mutation:cds:p.E264V(human)
RGD
PMID:11140575 PMID:20170533
RGD:1643168 , RGD:14695048
NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:122,866,312...122,888,339
G
Serpina6
serpin family A member 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 6:128,544,828...128,555,064
Ensembl chr 6:122,780,043...122,790,349
G
Serpine1
serpin family E member 1
treatment
ISO
associated with precursor lymphoblastic lymphoma/leukemia;DNA:SNPs: :DNA:SNPs: :677C>T, 1298A>C(human)
RGD
PMID:23183238
RGD:14696750
NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657
G
Serping1
serpin family G member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:69,842,739...69,852,034
G
Sesn2
sestrin 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:28209544
NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:144,701,530...144,721,260
G
Sgf29
SAGA complex associated factor 29
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 1:190,668,803...190,702,500
Ensembl chr 1:181,238,468...181,274,781
G
Shc1
SHC adaptor protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249 PMID:32659284
NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:174,837,930...174,849,536
G
Slc10a1
solute carrier family 10 member 1
IEP
mRNA:decreased expression:liver (rat)
RGD
PMID:28827769
RGD:15045609
NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:100,613,045...100,626,670
G
Slc10a7
solute carrier family 10, member 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chr19:29,183,143...29,407,470
Ensembl chr19:29,183,155...29,407,464
G
Slc13a4
solute carrier family 13 member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 4:64,910,505...64,955,986
Ensembl chr 4:63,943,395...63,988,857
G
Slc22a8
solute carrier family 22 member 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:205,498,084...205,517,450
G
Slc25a29
solute carrier family 25 member 29
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 6:133,506,403...133,517,322
Ensembl chr 6:127,742,033...127,752,940
G
Slc7a5
solute carrier family 7 member 5
treatment
IEP
RGD
PMID:9200186
RGD:151357001
NCBI chr19:66,843,808...66,872,412
Ensembl chr19:49,935,220...49,963,823
G
Slpi
secretory leukocyte peptidase inhibitor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17984051
NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:153,082,369...153,084,453
G
Snx18
sorting nexin 18
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17984051
NCBI chr 2:45,232,325...45,258,345
Ensembl chr 2:45,232,325...45,258,345
G
Sod1
superoxide dismutase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750 PMID:27349771
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
G
Sod2
superoxide dismutase 2
susceptibility severity treatment
ISO IMP
CTD Direct Evidence: marker/mechanism DNA:SNP:cds:p.Val16Ala(human) associated with acute lymphoblastic leukemia;DNA:SNP: :(rs4880)(human)
CTD RGD
PMID:25226513 PMID:20578157 PMID:19332662 PMID:19647030 PMID:27019981
RGD:26923957 , RGD:26923959 , RGD:26923961 , RGD:11060605
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
G
Sod3
superoxide dismutase 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11529661
NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990
G
Sord
sorbitol dehydrogenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12763371
NCBI chr 3:129,638,282...129,669,727
Ensembl chr 3:109,184,676...109,216,133
G
Sorl1
sortilin related receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chr 8:51,238,713...51,401,458
Ensembl chr 8:42,341,704...42,504,513
G
Spin2a
spindlin family member 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chr X:20,847,871...20,849,854
Ensembl chr X:17,511,022...17,513,001
G
Spp1
secreted phosphoprotein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162
G
Srp72
signal recognition particle 72
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chr14:31,168,175...31,195,717
Ensembl chr14:31,168,293...31,195,729
G
Stat3
signal transducer and activator of transcription 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:38460807
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
G
Stat4
signal transducer and activator of transcription 4
severity
ISO
protein:increased phosphorylation:liver, inflammatory cell (mouse) mRNA:increased expression:liver, macrophage (mouse)
RGD
PMID:24731448 PMID:23876342
RGD:25671417 , RGD:25671422
NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:49,419,340...49,588,540
G
Sting1
stimulator of interferon response cGAMP interactor 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:36520315
NCBI chr18:27,606,196...27,612,544
Ensembl chr18:27,332,119...27,338,335
G
Sult1c3
sulfotransferase family 1C member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 9:7,548,839...7,594,299
Ensembl chr 9:7,221,578...7,267,030
G
Sult1e1
sulfotransferase family 1E member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,422,324...20,439,275
G
Sult2b1
sulfotransferase family 2B member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27052460
NCBI chr 1:105,336,614...105,397,744
Ensembl chr 1:96,200,156...96,261,295
G
Suox
sulfite oxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 7:1,687,666...1,691,759
Ensembl chr 7:1,103,151...1,107,038
G
Tagln2
transgelin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr13:87,499,350...87,506,328
Ensembl chr13:84,967,009...84,973,972
G
Taldo1
transaldolase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19436114
NCBI chr 1:205,923,196...205,933,526
Ensembl chr 1:196,493,589...196,503,974
G
Tbxa2r
thromboxane A2 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22206755
NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:8,383,378...8,388,176
G
Tctn1
tectonic family member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17984051
NCBI chr12:34,309,795...34,347,190
Ensembl chr12:34,309,897...34,342,267
G
Tf
transferrin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:103,767,995...103,816,511
G
Tgfb1
transforming growth factor, beta 1
treatment
ISO
RGD
PMID:27516150
RGD:14995464
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
G
Tgfbr1
transforming growth factor, beta receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28560358
NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777
G
Thbs1
thrombospondin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:35357534
NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:105,056,292...105,071,440
G
Thpo
thrombopoietin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:33122006
Ensembl chr11:80,182,820...80,188,167
G
Tlr4
toll-like receptor 4
disease_progression
IEP
RGD
PMID:17504260
RGD:14697733
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
G
Tlr5
toll-like receptor 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30508503
NCBI chr13:97,166,430...97,190,642
Ensembl chr13:94,634,801...94,657,738
G
Tlr9
toll-like receptor 9
severity treatment
ISO
protein:increased expression: blood, neutrophil (human)
RGD
PMID:26457748 PMID:23509352 PMID:19164858
RGD:18337465 , RGD:18337473 , RGD:18337476
NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:106,864,680...106,868,796
G
Tmed7
transmembrane p24 trafficking protein 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chr18:41,505,167...41,512,243
Ensembl chr18:39,297,351...39,325,640
G
Tmem117
transmembrane protein 117
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chr 7:127,636,862...128,098,944
Ensembl chr 7:125,757,591...126,219,690
G
Tmem164
transmembrane protein 164
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr X:111,084,830...111,245,419
Ensembl chr X:106,289,371...106,448,640
G
Tmem38b
transmembrane protein 38B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 5:73,255,662...73,291,383
Ensembl chr 5:68,460,304...68,496,025
G
Tnf
tumor necrosis factor
treatment severity
IDA IEP ISO IMP
protein:increased expression:serum (rat) CTD Direct Evidence: marker/mechanism|therapeutic
CTD RGD
PMID:7532385 PMID:9696492 PMID:17709330 PMID:19638433 PMID:20623750 PMID:21984482 PMID:37866487 PMID:15830285 PMID:11124822 PMID:31077717 PMID:17070847 PMID:9309314 PMID:10801287 PMID:10801288 PMID:14686721 PMID:31342809 PMID:29091898 More...
RGD:10450531 , RGD:14696804 , RGD:14975281 , RGD:14995429 , RGD:14995432 , RGD:14995435 , RGD:14995437 , RGD:14995485 , RGD:15036799 , RGD:15090820
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Trpm2
transient receptor potential cation channel, subfamily M, member 2
ISO
RGD
PMID:24569808
RGD:9999438
NCBI chr20:10,703,190...10,752,795
Ensembl chr20:10,707,014...10,753,181
G
Ttr
transthyretin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16099942
NCBI chr18:12,216,684...12,225,972
Ensembl chr18:11,943,789...11,951,008
G
Tuba1a
tubulin, alpha 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 7:131,992,151...131,996,850
Ensembl chr 7:130,081,032...130,196,186
G
Tubb4b
tubulin, beta 4B class IVb
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 3:28,435,999...28,438,455
Ensembl chr 3:8,037,799...8,040,296
G
Uba5
ubiquitin-like modifier activating enzyme 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26881866
NCBI chr 8:113,544,037...113,559,711
Ensembl chr 8:104,665,046...104,680,894
G
Ugt1a1
UDP glucuronosyltransferase family 1 member A1
susceptibility
ISO
DNA:SNP:exon (rs4148323)(human)
RGD
PMID:28900877
RGD:14694824
NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a9
UDP glucuronosyltransferase family 1 member A9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20623750
NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465
G
Unc93b1
unc-93 homolog B1, TLR signaling regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 1:210,596,639...210,607,579
Ensembl chr 1:201,152,693...201,178,338
G
Usp5
ubiquitin specific peptidase 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 4:159,305,927...159,321,345
Ensembl chr 4:157,619,643...157,634,711
G
Ust5r
integral membrane transport protein UST5r
EXP
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 1:214,640,172...214,716,024
Ensembl chr 1:205,211,034...205,286,718
G
Vegfa
vascular endothelial growth factor A
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:25231249 PMID:17784864
RGD:15003197
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
G
Vim
vimentin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
G
Vwf
von Willebrand factor
IEP ISO
protein:increased expression:liver: CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:28527913 PMID:7531171
RGD:11079232
NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:158,360,152...158,491,539
G
Wasl
WASP like actin nucleation promoting factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 4:54,049,081...54,097,653
Ensembl chr 4:53,083,536...53,132,022
G
Xrcc1
X-ray repair cross complementing 1
susceptibility
ISO
DNA:haploinsufficiency: : (mouse)
RGD
PMID:21737425
RGD:15036796
NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:80,141,207...80,168,701
G
Xylb
xylulokinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25231249
NCBI chr 8:127,971,194...128,012,511
Ensembl chr 8:119,096,029...119,128,848
G
Zdhhc23
zinc finger DHHC-type palmitoyltransferase 23
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr11:70,224,581...70,240,971
Ensembl chr11:56,718,826...56,734,194
Symbol
Object Name
Qualifiers
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
Abcc2
ATP binding cassette subfamily C member 2
susceptibility no_association
ISO
DNA:polymorphisms,haplotype:promoter:g.-1774delG,g.-1549G>A(human) DNA:SNPs:multiple:
RGD
PMID:17502832 PMID:22178260
RGD:14700816 , RGD:14700817
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
IDA
DNA:hypermethylation:promoter
RGD
PMID:23619520
RGD:14700910
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
IDA
RGD
PMID:16140414
RGD:2316848
NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
G
Lpar1
lysophosphatidic acid receptor 1
ISO
protein:increased expression:liver (mouse)
RGD
PMID:12201952
RGD:10054288
NCBI chr 5:78,024,139...78,147,071
Ensembl chr 5:73,229,625...73,369,895
G
Mir22
microRNA 22
ISO
in male; RNA:increased expression:liver:
RGD
PMID:21750200
RGD:14700876
NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,307,039...60,307,133
Symbol
Object Name
Qualifiers
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
Gpt
glutamic--pyruvic transaminase
treatment
IEP
RGD
PMID:28921207
RGD:14975164
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
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