Mir1b (microRNA 1b) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Mir1b (microRNA 1b) Rattus norvegicus
Analyze
Symbol: Mir1b
Name: microRNA 1b
RGD ID: 9685084
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including miRNA-mediated gene silencing; negative regulation of cell population proliferation; and regulation of monoatomic cation transmembrane transport. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; post-transcriptional regulation of gene expression; and regulation of calcineurin-NFAT signaling cascade. Predicted to be located in extracellular space. Predicted to be part of RISC complex. Orthologous to human MIR1-1 (microRNA 1-1); INTERACTS WITH arsenic trichloride (ortholog); arsenous acid (ortholog); benzo[a]pyrene (ortholog).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-mir-1b
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23167,487,117 - 167,487,201 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3167,487,117 - 167,487,201 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3171,863,849 - 171,863,933 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03180,822,941 - 180,823,025 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03177,488,028 - 177,488,112 (+)NCBIRnor_WKY
Rnor_6.03175,769,716 - 175,769,800 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3175,769,716 - 175,769,800 (+)EnsemblRnor6.0rn6Rnor6.0
Celera3165,093,074 - 165,093,158 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell migration involved in coronary vasculogenesis  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
miRNA-mediated gene silencing  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of delayed rectifier potassium channel activity  (ISO)
negative regulation of endothelial cell differentiation  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of lipid biosynthetic process  (ISO)
negative regulation of membrane repolarization during cardiac muscle cell action potential  (ISO)
negative regulation of myoblast proliferation  (ISO)
negative regulation of translation  (ISO)
negative regulation of transporter activity  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane  (ISO)
positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of mesoderm formation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
post-transcriptional regulation of gene expression  (ISO)
regulation of calcineurin-NFAT signaling cascade  (ISO)
regulation of gene expression  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
reversible differentiation  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:6466370   PMID:15361871   PMID:16381832   PMID:19188439   PMID:20439489   PMID:21690310   PMID:23185045   PMID:23571754   PMID:23799049   PMID:33969678  


Genomics

Comparative Map Data
Mir1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23167,487,117 - 167,487,201 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3167,487,117 - 167,487,201 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3171,863,849 - 171,863,933 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03180,822,941 - 180,823,025 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03177,488,028 - 177,488,112 (+)NCBIRnor_WKY
Rnor_6.03175,769,716 - 175,769,800 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3175,769,716 - 175,769,800 (+)EnsemblRnor6.0rn6Rnor6.0
Celera3165,093,074 - 165,093,158 (-)NCBICelera
Cytogenetic Map3q43NCBI
MIR1-1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382062,554,306 - 62,554,376 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2062,554,306 - 62,554,376 (+)EnsemblGRCh38hg38GRCh38
GRCh372061,151,513 - 61,151,583 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362060,561,957 - 60,562,027 (+)NCBINCBI36Build 36hg18NCBI36
Celera2057,861,849 - 57,861,919 (+)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2057,906,156 - 57,906,226 (+)NCBIHuRef
CHM1_12061,052,572 - 61,052,642 (+)NCBICHM1_1
T2T-CHM13v2.02064,352,831 - 64,352,901 (+)NCBIT2T-CHM13v2.0
Mir1a-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,030,841 - 180,030,917 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,030,841 - 180,030,917 (+)EnsemblGRCm39 Ensembl
GRCm382180,389,048 - 180,389,124 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2180,389,048 - 180,389,124 (+)EnsemblGRCm38mm10GRCm38
MGSCv372180,123,753 - 180,123,829 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera2184,473,969 - 184,474,045 (+)NCBICelera
Cytogenetic Map2H4NCBI
MIR1-1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12446,481,078 - 46,481,136 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2446,481,078 - 46,481,136 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.02447,351,556 - 47,351,614 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12446,452,779 - 46,452,837 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02446,575,983 - 46,576,041 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02447,330,532 - 47,330,590 (+)NCBIUU_Cfam_GSD_1.0
MIR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1761,894,036 - 61,894,143 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11761,894,036 - 61,894,143 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21769,285,393 - 69,285,500 (-)NCBISscrofa10.2Sscrofa10.2susScr3


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 5 8 10 8
Low 20 1 1 5 7
Below cutoff 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_128704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000080061
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3167,487,117 - 167,487,201 (+)Ensembl
Rnor_6.0 Ensembl3175,769,716 - 175,769,800 (+)Ensembl
RefSeq Acc Id: NR_128704
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23167,487,117 - 167,487,201 (+)NCBI
Rnor_6.03175,769,716 - 175,769,800 (+)NCBI
Celera3165,093,074 - 165,093,158 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:9685084 AgrOrtholog
BioCyc Gene G2FUF-46336 BioCyc
Ensembl Genes ENSRNOG00000057048 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000080061 ENTREZGENE
miRBase MI0031785 ENTREZGENE
NCBI Gene Mir1b ENTREZGENE
PhenoGen Mir1b PhenoGen
RNAcentral URS00001DC04F RNACentral
  URS00007E48B7 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir1b  microRNA 1b  Mir1b  microRNA mir-1b  Name updated 61478 APPROVED
2014-12-16 Mir1b  microRNA mir-1b      Symbol and Name status set to provisional 70820 PROVISIONAL