Ido2 (indoleamine 2,3-dioxygenase 2) - Rat Genome Database

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Gene: Ido2 (indoleamine 2,3-dioxygenase 2) Rattus norvegicus
Analyze
Symbol: Ido2
Name: indoleamine 2,3-dioxygenase 2
RGD ID: 1596771
Description: Predicted to enable indoleamine 2,3-dioxygenase activity and tryptophan 2,3-dioxygenase activity. Predicted to be involved in 'de novo' NAD biosynthetic process from tryptophan and tryptophan catabolic process to kynurenine. Predicted to be active in cytoplasm. Orthologous to human IDO2 (indoleamine 2,3-dioxygenase 2); PARTICIPATES IN kynurenine metabolic pathway; sleeping sickness pathway; tryptophan metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IDO-2; Indol1; indoleamine 2,3-dioxygenase-like protein 1; indoleamine-pyrrole 2,3 dioxygenase-like 1; indoleamine-pyrrole 2,3-dioxygenase-like protein 1; LOC681319; similar to Indoleamine 2,3-dioxygenase (IDO) (Indoleamine-pyrrole 2,3-dioxygenase)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81674,161,761 - 74,200,651 (+)NCBIGRCr8
mRatBN7.21667,459,158 - 67,498,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,459,190 - 67,496,324 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01672,232,852 - 72,291,227 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1672,268,943 - 72,289,156 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,883,093 - 71,936,202 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41671,907,113 - 71,932,910 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1665,358,465 - 65,396,778 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Bessede A, etal., Nature. 2014 Jul 10;511(7508):184-90. doi: 10.1038/nature13323.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The kynurenine pathway and neurodegenerative disease. Maddison DC and Giorgini F, Semin Cell Dev Biol. 2015 Apr;40:134-41. doi: 10.1016/j.semcdb.2015.03.002. Epub 2015 Mar 12.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17499941   PMID:17671174   PMID:21841011  


Genomics

Comparative Map Data
Ido2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81674,161,761 - 74,200,651 (+)NCBIGRCr8
mRatBN7.21667,459,158 - 67,498,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,459,190 - 67,496,324 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01672,232,852 - 72,291,227 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1672,268,943 - 72,289,156 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,883,093 - 71,936,202 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41671,907,113 - 71,932,910 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1665,358,465 - 65,396,778 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
IDO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38839,934,651 - 40,016,392 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl839,934,614 - 40,016,392 (+)EnsemblGRCh38hg38GRCh38
GRCh37839,792,170 - 39,873,911 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36839,911,631 - 39,993,067 (+)NCBINCBI36Build 36hg18NCBI36
Celera838,744,208 - 38,825,740 (+)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef838,325,410 - 38,406,972 (+)NCBIHuRef
CHM1_1839,839,074 - 39,920,934 (+)NCBICHM1_1
T2T-CHM13v2.0840,211,488 - 40,293,321 (+)NCBIT2T-CHM13v2.0
Ido2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39825,021,908 - 25,066,430 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl825,021,908 - 25,066,349 (-)EnsemblGRCm39 Ensembl
GRCm38824,531,892 - 24,576,414 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl824,531,892 - 24,576,333 (-)EnsemblGRCm38mm10GRCm38
MGSCv37825,642,364 - 25,686,805 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36825,997,999 - 26,041,878 (-)NCBIMGSCv36mm8
Celera826,015,603 - 26,060,501 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map812.58NCBI
Ido2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555362,894,308 - 2,939,016 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555362,894,410 - 2,938,862 (-)NCBIChiLan1.0ChiLan1.0
IDO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2758,417,523 - 58,471,096 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1834,134,635 - 34,188,113 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0839,149,045 - 39,209,671 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1836,657,311 - 36,717,606 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl836,665,240 - 36,717,420 (+)Ensemblpanpan1.1panPan2
IDO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11625,319,035 - 25,375,085 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1625,319,035 - 25,385,515 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1625,828,791 - 25,884,813 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01627,148,250 - 27,202,111 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1627,148,250 - 27,212,554 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11625,444,124 - 25,500,130 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01625,999,883 - 26,055,903 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01626,058,662 - 26,114,701 (-)NCBIUU_Cfam_GSD_1.0
Ido2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494348,530,500 - 48,585,259 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936843594,968 - 649,390 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936843595,237 - 649,390 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl179,277,069 - 9,343,749 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1179,277,039 - 9,344,405 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21710,830,092 - 10,897,040 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IDO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1837,951,810 - 38,027,689 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl837,959,078 - 38,027,632 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660523,845,494 - 3,848,973 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ido2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247803,621,623 - 3,668,177 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247803,620,899 - 3,668,351 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ido2
376 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:54
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000032116
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 7 36 110 88 82 59 19 59 6 188 76 91 39 54 23

Sequence


Ensembl Acc Id: ENSRNOT00000032116   ⟹   ENSRNOP00000036799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1667,459,190 - 67,496,324 (+)Ensembl
Rnor_6.0 Ensembl1672,268,943 - 72,289,156 (+)Ensembl
RefSeq Acc Id: NM_001419674   ⟹   NP_001406603
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,161,780 - 74,200,651 (+)NCBI
mRatBN7.21667,459,186 - 67,498,052 (+)NCBI
RefSeq Acc Id: XM_039095215   ⟹   XP_038951143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,161,761 - 74,200,651 (+)NCBI
mRatBN7.21667,459,158 - 67,498,052 (+)NCBI
RefSeq Acc Id: XM_039095217   ⟹   XP_038951145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,176,436 - 74,200,651 (+)NCBI
mRatBN7.21667,473,846 - 67,498,052 (+)NCBI
RefSeq Acc Id: XM_039095218   ⟹   XP_038951146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,161,763 - 74,188,012 (+)NCBI
mRatBN7.21667,459,162 - 67,485,377 (+)NCBI
RefSeq Acc Id: XM_063275724   ⟹   XP_063131794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,176,431 - 74,200,651 (+)NCBI
Ensembl Acc Id: ENSRNOP00000036799   ⟸   ENSRNOT00000032116
RefSeq Acc Id: XP_038951143   ⟸   XM_039095215
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038951146   ⟸   XM_039095218
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038951145   ⟸   XM_039095217
- Peptide Label: isoform X2
- UniProtKB: A0A0N4SWI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001406603   ⟸   NM_001419674
- UniProtKB: F1LV46 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063131794   ⟸   XM_063275724
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LV46-F1-model_v2 AlphaFold F1LV46 1-405 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596771 AgrOrtholog
BioCyc Gene G2FUF-10937 BioCyc
BioCyc Pathway PWY-5651 [L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde] BioCyc
BioCyc Pathway Image PWY-5651 BioCyc
Ensembl Genes ENSRNOG00000025365 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00060011803 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000032116 UniProtKB/TrEMBL
  ENSRNOT00000032116.7 UniProtKB/Swiss-Prot
  ENSRNOT00060019977 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.480 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Indolamine_dOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trp/Indoleamine_2_3_dOase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 681319 ENTREZGENE
PANTHER INDOLEAMINE 2,3-DIOXYGENASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR28657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IDO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ido2 PhenoGen
RatGTEx ENSRNOG00000025365 RatGTEx
  ENSRNOG00060011803 RatGTEx
Superfamily-SCOP SSF140959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SWI7 ENTREZGENE, UniProtKB/TrEMBL
  F1LV46 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Ido2  indoleamine 2,3-dioxygenase 2  LOC684861  similar to Indoleamine 2,3-dioxygenase (IDO) (Indoleamine-pyrrole 2,3-dioxygenase)  Data merged from RGD:1585535 1643240 APPROVED
2009-02-04 Ido2  indoleamine 2,3-dioxygenase 2  Indol1  indoleamine-pyrrole 2,3 dioxygenase-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Indol1  indoleamine-pyrrole 2,3 dioxygenase-like 1  LOC681319  similar to Indoleamine 2,3-dioxygenase (IDO) (Indoleamine-pyrrole 2,3-dioxygenase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC681319  similar to Indoleamine 2,3-dioxygenase (IDO) (Indoleamine-pyrrole 2,3-dioxygenase)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684861  similar to Indoleamine 2,3-dioxygenase (IDO) (Indoleamine-pyrrole 2,3-dioxygenase)      Symbol and Name status set to provisional 70820 PROVISIONAL