Mir27b (microRNA 27b) - Rat Genome Database

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Gene: Mir27b (microRNA 27b) Rattus norvegicus
Symbol: Mir27b
Name: microRNA 27b
RGD ID: 2325593
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including negative regulation of cholesterol transport; positive regulation of cell population proliferation; and regulation of gene expression. Predicted to act upstream of or within several processes, including cellular response to forskolin; regulation of protein metabolic process; and regulation of signal transduction. Predicted to be located in extracellular exosome. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human MIR27B (microRNA 27b); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,5-hexanedione; aflatoxin B1.
Type: ncrna (Ensembl: miRNA)
Previously known as: microRNA mir-27b; rno-mir-27b
RGD Orthologs
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2171,813,427 - 1,813,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl171,813,426 - 1,813,529 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx171,832,126 - 1,832,222 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0173,374,724 - 3,374,820 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0171,829,576 - 1,829,672 (-)NCBIRnor_WKY
Rnor_6.017823,461 - 823,557 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl17823,461 - 823,557 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.017816,274 - 816,370 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera17709,223 - 709,319 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to forskolin  (ISO)
cellular response to inorganic substance  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
cholesterol homeostasis  (ISO)
miRNA-mediated gene silencing  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
myelination  (ISO)
negative regulation of cell adhesion molecule production  (ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of CoA-transferase activity  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of I-kappaB phosphorylation  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of lipid binding  (ISO)
negative regulation of low-density lipoprotein particle clearance  (ISO)
negative regulation of low-density lipoprotein particle receptor binding  (ISO)
negative regulation of monooxygenase activity  (ISO)
negative regulation of NIK/NF-kappaB signaling  (ISO)
negative regulation of receptor-mediated endocytosis involved in cholesterol transport  (ISO)
negative regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
obsolete regulation of cholesterol esterification  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of cell adhesion involved in sprouting angiogenesis  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
regulation of gene expression  (ISO)
regulation of semaphorin-plexin signaling pathway  (ISO)
regulation of superoxide metabolic process  (ISO)
response to bacterium  (ISO)
retina vasculature development in camera-type eye  (ISO)
sensory perception of sound  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. The miR27b-CCNG1-P53-miR-508-5p axis regulates multidrug resistance of gastric cancer. Shang Y, etal., Oncotarget. 2016 Jan 5;7(1):538-49. doi: 10.18632/oncotarget.6374.
Additional References at PubMed
PMID:16381832   PMID:16682203   PMID:16766679   PMID:17604727   PMID:17805466   PMID:20403161   PMID:20439489   PMID:20805985   PMID:21536891   PMID:21993888   PMID:23613728   PMID:23646144  
PMID:24205035   PMID:24815159   PMID:25795136   PMID:27716060   PMID:27863390   PMID:28484848   PMID:28943435   PMID:29187585   PMID:29777440   PMID:30549040   PMID:31881012   PMID:32170506  
PMID:35282795   PMID:35599576   PMID:35818274  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2171,813,427 - 1,813,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl171,813,426 - 1,813,529 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx171,832,126 - 1,832,222 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0173,374,724 - 3,374,820 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0171,829,576 - 1,829,672 (-)NCBIRnor_WKY
Rnor_6.017823,461 - 823,557 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl17823,461 - 823,557 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.017816,274 - 816,370 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera17709,223 - 709,319 (+)NCBICelera
Cytogenetic Map17p14NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38995,085,445 - 95,085,541 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl995,085,445 - 95,085,541 (+)EnsemblGRCh38hg38GRCh38
GRCh37997,847,727 - 97,847,823 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36996,887,547 - 96,887,643 (+)NCBINCBI36Build 36hg18NCBI36
Celera968,288,758 - 68,288,854 (+)NCBICelera
Cytogenetic Map9q22.32NCBI
HuRef967,457,280 - 67,457,376 (+)NCBIHuRef
CHM1_1997,994,205 - 97,994,301 (+)NCBICHM1_1
T2T-CHM13v2.09107,254,838 - 107,254,934 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391363,448,526 - 63,448,598 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1363,448,526 - 63,448,598 (+)EnsemblGRCm39 Ensembl
GRCm381363,300,712 - 63,300,784 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1363,300,712 - 63,300,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv371363,402,020 - 63,402,092 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1364,954,893 - 64,954,965 (+)NCBICelera
Cytogenetic Map13B3NCBI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1171,678,117 - 71,678,179 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl171,678,105 - 71,678,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha172,440,078 - 72,440,140 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0171,982,476 - 71,982,538 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl171,982,464 - 71,982,550 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1171,793,881 - 71,793,943 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0171,557,950 - 71,558,012 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0172,264,234 - 72,264,296 (-)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1027,079,954 - 27,080,056 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11027,079,963 - 27,080,042 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,340,880 - 31,340,959 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Rxrarno-miR-27b-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19185571

Predicted Targets
Summary Value
Count of predictions:10978
Count of gene targets:6544
Count of transcripts:7021
Interacting mature miRNAs:rno-miR-27b-3p, rno-miR-27b-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2171,813,609 - 1,813,797 (-)MAPPERmRatBN7.2
Rnor_6.017823,188 - 823,375NCBIRnor6.0
Rnor_5.017816,001 - 816,188UniSTSRnor5.0
RGSC_v3.4177,351,631 - 7,351,818UniSTSRGSC3.4
Celera17708,950 - 709,137UniSTS
RH 3.4 Map1710.5UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 8 21 7 10 7 8 8 20 12 11 8 8
Low 2 25 13 11 8 11 3 44 20 25 3
Below cutoff 2 5 5 1 5 4 1 1


Nucleotide Sequences
RefSeq Transcripts NR_031832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000053699
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl171,813,426 - 1,813,529 (-)Ensembl
Rnor_6.0 Ensembl17823,461 - 823,557 (+)Ensembl
RefSeq Acc Id: NR_031832
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,813,427 - 1,813,523 (-)NCBI
Rnor_6.017823,461 - 823,557 (+)NCBI
Rnor_5.017816,274 - 816,370 (+)NCBI
Celera17709,223 - 709,319 (+)NCBI

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325593 AgrOrtholog
BioCyc Gene G2FUF-10518 BioCyc
Ensembl Genes ENSRNOG00000035576 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053699 ENTREZGENE
miRBase MI0000859 ENTREZGENE
NCBI Gene 100314005 ENTREZGENE
PhenoGen Mir27b PhenoGen
RNAcentral URS000059311D RNACentral
  URS000075B0A5 RNACentral
  URS000075D23F RNACentral

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir27b  microRNA 27b  Mir27b  microRNA mir-27b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir27b  microRNA mir-27b      Symbol and Name status set to provisional 70820 PROVISIONAL