MIR27B (microRNA mir-27b) - Rat Genome Database

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Gene: MIR27B (microRNA mir-27b) Canis lupus familiaris
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Symbol: MIR27B
Name: microRNA mir-27b
RGD ID: 12424191
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Previously known as: cfa-mir-27b; microRNA 27b
RGD Orthologs
Human
Mouse
Rat
Pig
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1171,678,117 - 71,678,179 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl171,678,105 - 71,678,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha172,440,078 - 72,440,140 (-)NCBI
ROS_Cfam_1.0171,982,476 - 71,982,538 (-)NCBI
UMICH_Zoey_3.1171,793,881 - 71,793,943 (-)NCBI
UNSW_CanFamBas_1.0171,557,950 - 71,558,012 (-)NCBI
UU_Cfam_GSD_1.0172,264,234 - 72,264,296 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to forskolin  (ISO)
cellular response to inorganic substance  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
cholesterol homeostasis  (ISO)
miRNA-mediated gene silencing  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
myelination  (ISO)
negative regulation of cell adhesion molecule production  (ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of CoA-transferase activity  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of I-kappaB phosphorylation  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of lipid binding  (ISO)
negative regulation of low-density lipoprotein particle clearance  (ISO)
negative regulation of low-density lipoprotein particle receptor binding  (ISO)
negative regulation of monooxygenase activity  (ISO)
negative regulation of NIK/NF-kappaB signaling  (ISO)
negative regulation of receptor-mediated endocytosis involved in cholesterol transport  (ISO)
negative regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of cell adhesion involved in sprouting angiogenesis  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
regulation of gene expression  (ISO)
regulation of semaphorin-plexin signaling pathway  (ISO)
regulation of superoxide metabolic process  (ISO)
response to bacterium  (ISO)
retina vasculature development in camera-type eye  (ISO)
sensory perception of sound  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:16381832   PMID:18392026  


Genomics

Comparative Map Data
MIR27B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1171,678,117 - 71,678,179 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl171,678,105 - 71,678,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha172,440,078 - 72,440,140 (-)NCBI
ROS_Cfam_1.0171,982,476 - 71,982,538 (-)NCBI
UMICH_Zoey_3.1171,793,881 - 71,793,943 (-)NCBI
UNSW_CanFamBas_1.0171,557,950 - 71,558,012 (-)NCBI
UU_Cfam_GSD_1.0172,264,234 - 72,264,296 (-)NCBI
MIR27B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38995,085,445 - 95,085,541 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl995,085,445 - 95,085,541 (+)EnsemblGRCh38hg38GRCh38
GRCh37997,847,727 - 97,847,823 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36996,887,547 - 96,887,643 (+)NCBINCBI36hg18NCBI36
Celera968,288,758 - 68,288,854 (+)NCBI
Cytogenetic Map9q22.32NCBI
HuRef967,457,280 - 67,457,376 (+)NCBIHuRef
CHM1_1997,994,205 - 97,994,301 (+)NCBICHM1_1
T2T-CHM13v2.09107,254,838 - 107,254,934 (+)NCBI
Mir27b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391363,448,526 - 63,448,598 (+)NCBIGRCm39mm39
GRCm39 Ensembl1363,448,526 - 63,448,598 (+)Ensembl
GRCm381363,300,712 - 63,300,784 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1363,300,712 - 63,300,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv371363,402,020 - 63,402,092 (+)NCBIGRCm37mm9NCBIm37
Celera1364,954,893 - 64,954,965 (+)NCBICelera
Cytogenetic Map13B3NCBI
Mir27b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2171,813,427 - 1,813,523 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl171,813,426 - 1,813,529 (-)Ensembl
Rnor_6.017823,461 - 823,557 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl17823,461 - 823,557 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.017816,274 - 816,370 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera17709,223 - 709,319 (+)NCBICelera
Cytogenetic Map17p14NCBI
MIR27B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1027,079,954 - 27,080,056 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11027,079,963 - 27,080,042 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,340,880 - 31,340,959 (-)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000032681
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl171,678,105 - 71,678,191 (-)Ensembl
RefSeq Acc Id: NR_049240
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1171,678,117 - 71,678,179 (-)NCBI
Dog10K_Boxer_Tasha172,440,078 - 72,440,140 (-)NCBI
ROS_Cfam_1.0171,982,476 - 71,982,538 (-)NCBI
UMICH_Zoey_3.1171,793,881 - 71,793,943 (-)NCBI
UNSW_CanFamBas_1.0171,557,950 - 71,558,012 (-)NCBI
UU_Cfam_GSD_1.0172,264,234 - 72,264,296 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000020574 Ensembl
  ENSCAFG00845005007 ENTREZGENE
Ensembl Transcript ENSCAFT00845008962 ENTREZGENE
miRBase MI0008009 ENTREZGENE
NCBI Gene MIR27B ENTREZGENE
RNAcentral URS000059311D RNACentral
  URS00007E377C RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR27B  microRNA mir-27b    microRNA 27b  Symbol and/or name change 5135510 APPROVED