MIR27B (microRNA 27b) - Rat Genome Database

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Gene: MIR27B (microRNA 27b) Homo sapiens
Analyze
Symbol: MIR27B
Name: microRNA 27b
RGD ID: 1343068
HGNC Page HGNC:31614
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including negative regulation of cholesterol transport; positive regulation of cell population proliferation; and regulation of gene expression. Acts upstream of or within regulation of protein metabolic process and regulation of signal transduction. Located in extracellular exosome. Implicated in stomach cancer. Biomarker of stomach cancer.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: MIR-27b; MIRN27B; miRNA27B
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38995,085,445 - 95,085,541 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl995,085,445 - 95,085,541 (+)EnsemblGRCh38hg38GRCh38
GRCh37997,847,727 - 97,847,823 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36996,887,547 - 96,887,643 (+)NCBINCBI36Build 36hg18NCBI36
Celera968,288,758 - 68,288,854 (+)NCBICelera
Cytogenetic Map9q22.32NCBI
HuRef967,457,280 - 67,457,376 (+)NCBIHuRef
CHM1_1997,994,205 - 97,994,301 (+)NCBICHM1_1
T2T-CHM13v2.09107,254,838 - 107,254,934 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to forskolin  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to vascular endothelial growth factor stimulus  (IDA,IGI)
cholesterol homeostasis  (IDA)
miRNA-mediated gene silencing by inhibition of translation  (IDA)
miRNA-mediated gene silencing by mRNA destabilization  (IDA)
miRNA-mediated post-transcriptional gene silencing  (IDA,IGI,IMP)
myelination  (ISO)
negative regulation of cell adhesion molecule production  (IDA)
negative regulation of cholesterol efflux  (IDA)
negative regulation of CoA-transferase activity  (IDA)
negative regulation of extracellular matrix assembly  (IDA)
negative regulation of fat cell differentiation  (IDA,IMP)
negative regulation of gene expression  (IDA,IMP)
negative regulation of interleukin-1 beta production  (IDA)
negative regulation of low-density lipoprotein particle clearance  (IDA)
negative regulation of monooxygenase activity  (IMP)
negative regulation of myofibroblast differentiation  (IDA)
negative regulation of nitric-oxide synthase activity  (ISS)
negative regulation of non-canonical NF-kappaB signal transduction  (IGI)
negative regulation of receptor-mediated endocytosis involved in cholesterol transport  (IDA)
negative regulation of transforming growth factor beta receptor signaling pathway  (IDA)
negative regulation of tumor necrosis factor-mediated signaling pathway  (IGI)
non-canonical NF-kappaB signal transduction  (ISS)
positive regulation of angiogenesis  (IMP,ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IDA,IGI)
positive regulation of cell adhesion involved in sprouting angiogenesis  (IMP)
positive regulation of cell migration involved in sprouting angiogenesis  (IDA,IGI)
positive regulation of cell proliferation in bone marrow  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IGI)
positive regulation of extracellular matrix assembly  (IDA)
positive regulation of gene expression  (IDA)
positive regulation of intrinsic apoptotic signaling pathway  (IGI)
positive regulation of lung blood pressure  (ISS)
positive regulation of pulmonary blood vessel remodeling  (ISS)
positive regulation of tumor necrosis factor production  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (ISS)
regulation of gene expression  (ISO)
regulation of semaphorin-plexin signaling pathway  (ISO)
regulation of superoxide metabolic process  (IGI)
response to angiotensin  (IDA)
response to bacterium  (ISO)
response to muscle activity  (ISO)
retina vasculature development in camera-type eye  (ISO)
sensory perception of sound  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. The miR27b-CCNG1-P53-miR-508-5p axis regulates multidrug resistance of gastric cancer. Shang Y, etal., Oncotarget. 2016 Jan 5;7(1):538-49. doi: 10.18632/oncotarget.6374.
3. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). Sun D, etal., J Biol Chem. 2013 Mar 29;288(13):9508-18. doi: 10.1074/jbc.M112.367763. Epub 2013 Jan 15.
Additional References at PubMed
PMID:12007417   PMID:12554860   PMID:14573789   PMID:16381832   PMID:16982751   PMID:17604727   PMID:17616659   PMID:19800867   PMID:20131257   PMID:20164187   PMID:20388705   PMID:20495621  
PMID:20888330   PMID:20889907   PMID:21037258   PMID:21536891   PMID:21562928   PMID:21899661   PMID:21922148   PMID:22077423   PMID:22120719   PMID:22127852   PMID:22184411   PMID:22213330  
PMID:22777896   PMID:22902387   PMID:23300597   PMID:23338610   PMID:23593282   PMID:24037889   PMID:24133204   PMID:24177325   PMID:24312312   PMID:24378438   PMID:24390089   PMID:24401318  
PMID:24608080   PMID:24633904   PMID:25012245   PMID:25014580   PMID:25115396   PMID:25333344   PMID:25405368   PMID:25505194   PMID:25698578   PMID:25795136   PMID:26026166   PMID:26065921  
PMID:26244871   PMID:26395742   PMID:26397063   PMID:26460960   PMID:26473412   PMID:26520906   PMID:26576539   PMID:26583473   PMID:26631623   PMID:26646931   PMID:26706910   PMID:26780940  
PMID:26846382   PMID:26898757   PMID:26910911   PMID:26999003   PMID:27252405   PMID:27345723   PMID:27363334   PMID:27456084   PMID:27573718   PMID:27694794   PMID:27809310   PMID:27844448  
PMID:28081743   PMID:28095798   PMID:28159509   PMID:28214904   PMID:28343438   PMID:28351320   PMID:28356525   PMID:28396577   PMID:28529949   PMID:28702332   PMID:28798470   PMID:28934732  
PMID:29028088   PMID:29102917   PMID:29135973   PMID:29222197   PMID:29280351   PMID:29368136   PMID:29393383   PMID:29416005   PMID:29455245   PMID:29608331   PMID:29725252   PMID:29794473  
PMID:29858119   PMID:29924913   PMID:29935035   PMID:30012170   PMID:30078021   PMID:30276874   PMID:30357841   PMID:30361294   PMID:30400755   PMID:30418194   PMID:30679767   PMID:30684280  
PMID:30729664   PMID:30973209   PMID:31006800   PMID:31046802   PMID:31066587   PMID:31124343   PMID:31253120   PMID:31388051   PMID:31415657   PMID:31539861   PMID:31587435   PMID:31763673  
PMID:31768842   PMID:31881012   PMID:31887300   PMID:32112986   PMID:32357145   PMID:32567955   PMID:32605321   PMID:32705233   PMID:32770398   PMID:32782028   PMID:32924375   PMID:33000178  
PMID:33015156   PMID:33106979   PMID:33128918   PMID:33137311   PMID:33171483   PMID:33174006   PMID:33191714   PMID:33212990   PMID:33350453   PMID:33413548   PMID:33454903   PMID:33570696  
PMID:33638619   PMID:33639023   PMID:33671389   PMID:33760199   PMID:33849101   PMID:33907846   PMID:34091806   PMID:34162761   PMID:34879814   PMID:35039595   PMID:35230909   PMID:35327987  
PMID:35345380   PMID:35459765   PMID:35460174   PMID:35483451   PMID:35791923   PMID:36138344   PMID:37003179   PMID:37328872   PMID:37355744   PMID:37371125   PMID:37485765   PMID:37501162  
PMID:37574723   PMID:37824390  


Genomics

Comparative Map Data
MIR27B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38995,085,445 - 95,085,541 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl995,085,445 - 95,085,541 (+)EnsemblGRCh38hg38GRCh38
GRCh37997,847,727 - 97,847,823 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36996,887,547 - 96,887,643 (+)NCBINCBI36Build 36hg18NCBI36
Celera968,288,758 - 68,288,854 (+)NCBICelera
Cytogenetic Map9q22.32NCBI
HuRef967,457,280 - 67,457,376 (+)NCBIHuRef
CHM1_1997,994,205 - 97,994,301 (+)NCBICHM1_1
T2T-CHM13v2.09107,254,838 - 107,254,934 (+)NCBIT2T-CHM13v2.0
Mir27b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391363,448,526 - 63,448,598 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1363,448,526 - 63,448,598 (+)EnsemblGRCm39 Ensembl
GRCm381363,300,712 - 63,300,784 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1363,300,712 - 63,300,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv371363,402,020 - 63,402,092 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1364,954,893 - 64,954,965 (+)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1332.8NCBI
Mir27b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8171,819,147 - 1,819,243 (-)NCBIGRCr8
mRatBN7.2171,813,427 - 1,813,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl171,813,426 - 1,813,529 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx171,832,126 - 1,832,222 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0173,374,724 - 3,374,820 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0171,829,576 - 1,829,672 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.017823,461 - 823,557 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl17823,461 - 823,557 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.017816,274 - 816,370 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera17709,223 - 709,319 (+)NCBICelera
Cytogenetic Map17p14NCBI
MIR27B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1171,678,117 - 71,678,179 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl171,678,105 - 71,678,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha172,440,078 - 72,440,140 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0171,982,476 - 71,982,538 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl171,982,464 - 71,982,550 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1171,793,881 - 71,793,943 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0171,557,950 - 71,558,012 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0172,264,234 - 72,264,296 (-)NCBIUU_Cfam_GSD_1.0
MIR27B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1027,079,954 - 27,080,056 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11027,079,963 - 27,080,042 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,340,880 - 31,340,959 (-)NCBISscrofa10.2Sscrofa10.2susScr3


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q22.31-22.33(chr9:91596533-97018746)x1 copy number loss See cases [RCV000052916] Chr9:91596533..97018746 [GRCh38]
Chr9:94358815..99781028 [GRCh37]
Chr9:93398636..98820849 [NCBI36]
Chr9:9q22.31-22.33
pathogenic
GRCh38/hg38 9q22.32(chr9:95046229-96111163)x1 copy number loss See cases [RCV000052918] Chr9:95046229..96111163 [GRCh38]
Chr9:97808511..98873445 [GRCh37]
Chr9:96848332..97913266 [NCBI36]
Chr9:9q22.32
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q22.31-22.33(chr9:92561720-98122580)x3 copy number gain See cases [RCV000053773] Chr9:92561720..98122580 [GRCh38]
Chr9:95324002..100884862 [GRCh37]
Chr9:94363823..99924683 [NCBI36]
Chr9:9q22.31-22.33
pathogenic
GRCh38/hg38 9q22.1-32(chr9:88522292-113687796)x3 copy number gain See cases [RCV000053752] Chr9:88522292..113687796 [GRCh38]
Chr9:91137207..116450076 [GRCh37]
Chr9:90327027..115489897 [NCBI36]
Chr9:9q22.1-32
pathogenic
GRCh38/hg38 9q22.32-31.2(chr9:94184266-106730550)x3 copy number gain See cases [RCV000053774] Chr9:94184266..106730550 [GRCh38]
Chr9:96946548..109492831 [GRCh37]
Chr9:95986369..108532652 [NCBI36]
Chr9:9q22.32-31.2
pathogenic
Single allele deletion Intellectual disability [RCV001293373] Chr9:97834573..107199088 [GRCh37]
Chr9:9q22.32-31.1
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q22.32-31.3(chr9:95061030-108695569)x1 copy number loss See cases [RCV000134375] Chr9:95061030..108695569 [GRCh38]
Chr9:97823312..111457849 [GRCh37]
Chr9:96863133..110497670 [NCBI36]
Chr9:9q22.32-31.3
pathogenic
GRCh38/hg38 9q22.32-22.33(chr9:94713892-98121186)x1 copy number loss See cases [RCV000135303] Chr9:94713892..98121186 [GRCh38]
Chr9:97476174..100883468 [GRCh37]
Chr9:96515995..99923289 [NCBI36]
Chr9:9q22.32-22.33
pathogenic
GRCh38/hg38 9q21.11-31.2(chr9:68420430-106579493)x3 copy number gain See cases [RCV000136788] Chr9:68420430..106579493 [GRCh38]
Chr9:71130848..109341774 [GRCh37]
Chr9:70225166..108381595 [NCBI36]
Chr9:9q21.11-31.2
pathogenic
GRCh38/hg38 9q22.31-22.32(chr9:93574616-95115422)x4 copy number gain See cases [RCV000138068] Chr9:93574616..95115422 [GRCh38]
Chr9:96336898..97877704 [GRCh37]
Chr9:95376719..96917525 [NCBI36]
Chr9:9q22.31-22.32
uncertain significance
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic|conflicting data from submitters
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3
pathogenic
GRCh38/hg38 9q21.12-31.3(chr9:69627642-111454304)x3 copy number gain See cases [RCV000139789] Chr9:69627642..111454304 [GRCh38]
Chr9:72242558..114216584 [GRCh37]
Chr9:71432378..113256405 [NCBI36]
Chr9:9q21.12-31.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q22.32(97579146-99280739)x1 copy number loss Gorlin syndrome [RCV000201243] Chr9:94816864..96518457 [GRCh38]
Chr9:97579146..99280739 [GRCh37]
Chr9:9q22.32-22.33
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:163131-141122114)x3 copy number gain See cases [RCV000240081] Chr9:163131..141122114 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:62525-141006407) copy number gain See cases [RCV000449375] Chr9:62525..141006407 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020389)x3 copy number gain not specified [RCV003986800] Chr9:203861..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q22.32(chr9:97827936-98639567) copy number gain See cases [RCV000447201] Chr9:97827936..98639567 [GRCh37]
Chr9:9q22.32
likely pathogenic
GRCh37/hg19 9q22.32-22.33(chr9:97355862-99805480)x1 copy number loss See cases [RCV000445766] Chr9:97355862..99805480 [GRCh37]
Chr9:9q22.32-22.33
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203864-141020389)x3 copy number gain See cases [RCV000448978] Chr9:203864..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q22.32-31.1(chr9:97553176-102919383)x3 copy number gain See cases [RCV000510672] Chr9:97553176..102919383 [GRCh37]
Chr9:9q22.32-31.1
likely pathogenic
GRCh37/hg19 9q22.32-22.33(chr9:96732332-100175689)x1 copy number loss See cases [RCV000510346] Chr9:96732332..100175689 [GRCh37]
Chr9:9q22.32-22.33
pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71069743-140999928) copy number gain Global developmental delay [RCV000626548] Chr9:71069743..140999928 [GRCh37]
Chr9:9q21.11-34.3
likely pathogenic
GRCh37/hg19 9q22.32(chr9:97598179-97886491)x1 copy number loss See cases [RCV000512445] Chr9:97598179..97886491 [GRCh37]
Chr9:9q22.32
uncertain significance
GRCh37/hg19 9p24.3-q34.3(chr9:203862-141020389) copy number gain See cases [RCV000512392] Chr9:203862..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q22.32(chr9:97698177-98849150)x1 copy number loss not provided [RCV000683154] Chr9:97698177..98849150 [GRCh37]
Chr9:9q22.32
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141122247)x3 copy number gain not provided [RCV000748055] Chr9:10590..141122247 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141107672)x3 copy number gain not provided [RCV000748053] Chr9:10590..141107672 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:46587-141066491)x3 copy number gain not provided [RCV000748063] Chr9:46587..141066491 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141114095)x2 copy number gain not provided [RCV000748054] Chr9:10590..141114095 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020388)x3 copy number gain not provided [RCV000845900] Chr9:203861..141020388 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71416475-141020389)x3 copy number gain not provided [RCV000847808] Chr9:71416475..141020389 [GRCh37]
Chr9:9q21.11-34.3
pathogenic
GRCh37/hg19 9q22.31-31.2(chr9:96126075-108535272)x1 copy number loss See cases [RCV001194520] Chr9:96126075..108535272 [GRCh37]
Chr9:9q22.31-31.2
pathogenic
NC_000009.11:g.12246100_101559378inv inversion Recurrent spontaneous abortion [RCV000999471] Chr9:12246100..101559378 [GRCh37]
Chr9:9p23-q22.33
likely pathogenic
GRCh37/hg19 9q22.32(chr9:97678918-98785455)x3 copy number gain not provided [RCV001827816] Chr9:97678918..98785455 [GRCh37]
Chr9:9q22.32
uncertain significance
GRCh37/hg19 9q21.11-33.2(chr9:71349994-122603410) copy number gain not specified [RCV002053853] Chr9:71349994..122603410 [GRCh37]
Chr9:9q21.11-33.2
likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:353349-141020389) copy number gain not specified [RCV002053823] Chr9:353349..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
NC_000009.11:g.(?_97365663)_(99064386_?)dup duplication not provided [RCV001943145] Chr9:97365663..99064386 [GRCh37]
Chr9:9q22.32
uncertain significance
GRCh37/hg19 9p22.1-q33.1(chr9:19356861-119513311) copy number loss Distal tetrasomy 15q [RCV002280776] Chr9:19356861..119513311 [GRCh37]
Chr9:9p22.1-q33.1
uncertain significance
GRCh37/hg19 9p24.3-q34.11(chr9:203861-131603223)x3 copy number gain See cases [RCV002292402] Chr9:203861..131603223 [GRCh37]
Chr9:9p24.3-q34.11
pathogenic
GRCh37/hg19 9q22.2-31.1(chr9:93864974-106661581)x1 copy number loss Gorlin syndrome [RCV002279743] Chr9:93864974..106661581 [GRCh37]
Chr9:9q22.2-31.1
pathogenic
GRCh37/hg19 9q22.31-22.32(chr9:95711603-98469214)x1 copy number loss not provided [RCV002474678] Chr9:95711603..98469214 [GRCh37]
Chr9:9q22.31-22.32
pathogenic
Single allele deletion not provided [RCV003448676] Chr9:92679543..109378847 [GRCh37]
Chr9:9q22.2-31.2
pathogenic
GRCh37/hg19 9q22.32(chr9:96614972-98444423)x1 copy number loss not specified [RCV003986837] Chr9:96614972..98444423 [GRCh37]
Chr9:9q22.32
pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
CDH2hsa-miR-27b-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
CCNT1hsa-miR-27b-3pMirtarbaseexternal_infoFlow//Luciferase reporter assay//Microarray//qRT-PFunctional MTI22205749
NOTCH1hsa-miR-27b-3pMirtarbaseexternal_infoReporter assayFunctional MTI17150773
NOTCH1hsa-miR-27b-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
PAX3hsa-miR-27b-3pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;Western Functional MTI19666532
CYP3A4hsa-miR-27b-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assayFunctional MTI19581388
ST14hsa-miR-27b-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Northern blFunctional MTI19546220
MMP13hsa-miR-27b-3pMirtarbaseexternal_infoELISA//Luciferase reporter assay//qRT-PCR//WesternFunctional MTI20131257
ADORA2Bhsa-miR-27b-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assayFunctional MTI20388705
CYP1B1hsa-miR-27b-3pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//qFunctional MTI16982751
PPARGhsa-miR-27b-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI19800867
PPARGhsa-miR-27b-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22120719
EDNRAhsa-miR-27b-3pMirtarbaseexternal_infoImmunofluorescence//In situ hybridization//LuciferFunctional MTI20827281
KHSRPhsa-miR-27b-3pMirtarbaseexternal_infoWestern blot, luciferase assayFunctional MTI22615562
PAX7hsa-miR-27b-3pMirtarbaseexternal_infoWestern blot;OtherFunctional MTI19666532
NOTCH1hsa-miR-27b-3pTarbaseexternal_infoReporter GenePOSITIVE
PAX3hsa-miR-27b-3pTarbaseexternal_infoWesternblitPOSITIVE
PAX3hsa-miR-27b-3pTarbaseexternal_infoOtherPOSITIVE
CYP1B1hsa-miR-27b-3pMirecordsexternal_infoNANA16982751
PPARGhsa-miR-27b-3pMirecordsexternal_info{changed}NA20164187
MMP13hsa-miR-27b-3pMirecordsexternal_infoNANA20131257
PPARGhsa-miR-27b-3pMirecordsexternal_info{changed}NA19800867
ST14hsa-miR-27b-3pMirecordsexternal_info{changed}NA19546220
DPYDhsa-miR-27b-3pOncomiRDBexternal_infoNANA22306127
PPARGhsa-miR-27b-3pOncomiRDBexternal_infoNANA22120719
APChsa-miR-27b-3pOncomiRDBexternal_infoNANA22018270
TFAP2Ahsa-miR-27b-3pOncomiRDBexternal_infoNANA21922148
ST14hsa-miR-27b-3pOncomiRDBexternal_infoNANA19546220
CYP1B1hsa-miR-27b-3pOncomiRDBexternal_infoNANA16982751

Predicted Targets
Summary Value
Count of predictions:29331
Count of gene targets:11052
Count of transcripts:21611
Interacting mature miRNAs:hsa-miR-27b-3p, hsa-miR-27b-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
287 1415 1116 1142 2118 627 1026 4 248 590 183 1128 3044 2653 50 1081 470 821 688 76

Sequence


Ensembl Acc Id: ENST00000385129
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl995,085,445 - 95,085,541 (+)Ensembl
RefSeq Acc Id: NR_029665
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38995,085,445 - 95,085,541 (+)NCBI
GRCh37997,847,727 - 97,847,823 (+)RGD
Celera968,288,758 - 68,288,854 (+)RGD
HuRef967,457,280 - 67,457,376 (+)ENTREZGENE
CHM1_1997,994,205 - 97,994,301 (+)NCBI
T2T-CHM13v2.09107,254,838 - 107,254,934 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31614 AgrOrtholog
COSMIC MIR27B COSMIC
Ensembl Genes ENSG00000207864 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385129 ENTREZGENE
GTEx ENSG00000207864 GTEx
HGNC ID HGNC:31614 ENTREZGENE
Human Proteome Map MIR27B Human Proteome Map
miRBase MI0000440 ENTREZGENE
NCBI Gene 407019 ENTREZGENE
OMIM 610636 OMIM
PharmGKB PA164722622 PharmGKB
RNAcentral URS0000330617 RNACentral
  URS000059311D RNACentral
  URS000075B0A5 RNACentral