Aldh1l2 (aldehyde dehydrogenase 1 family, member L2)

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Gene: Aldh1l2 (aldehyde dehydrogenase 1 family, member L2) Rattus norvegicus

Analyze

Symbol:

Aldh1l2

Name:

aldehyde dehydrogenase 1 family, member L2

RGD ID:

1309458

Description:

Predicted to enable aldehyde dehydrogenase (NAD+) activity and formyltetrahydrofolate dehydrogenase activity. Predicted to be involved in 10-formyltetrahydrofolate catabolic process; NADPH regeneration; and folic acid metabolic process. Predicted to act upstream of or within with a positive effect on fatty acid beta-oxidation. Predicted to be located in mitochondrion and nucleoplasm. Orthologous to human ALDH1L2 (aldehyde dehydrogenase 1 family member L2); PARTICIPATES IN folate mediated one-carbon metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC299699; mitochondrial 10-formyltetrahydrofolate dehydrogenase; probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2; RGD1309458; similar to RIKEN cDNA D330038I09

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ALDH1L2 (aldehyde dehydrogenase 1 family member L2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Aldh1l2 (aldehyde dehydrogenase 1 family, member L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Aldh1l2 (aldehyde dehydrogenase 1 family member L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ALDH1L2 (aldehyde dehydrogenase 1 family member L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ALDH1L2 (aldehyde dehydrogenase 1 family member L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Aldh1l2 (aldehyde dehydrogenase 1 family member L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ALDH1L2 (aldehyde dehydrogenase 1 family member L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ALDH1L2 (aldehyde dehydrogenase 1 family member L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Aldh1l2 (aldehyde dehydrogenase 1 family member L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ALDH1L2 (aldehyde dehydrogenase 1 family member L2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Aldh1l2 (aldehyde dehydrogenase 1 family, member L2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	aldh1l2 (aldehyde dehydrogenase 1 family, member L2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	ALD4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	ALD5	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	ALD6	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG8665	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	alh-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	20,254,196 - 20,305,793 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	20,254,233 - 20,305,776 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	22,226,671 - 22,277,861 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	24,389,426 - 24,440,621 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	24,166,438 - 24,217,632 (+)	NCBI	Rnor_WKY
Rnor_6.0	7	26,375,866 - 26,425,838 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	26,375,866 - 26,425,108 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	26,506,321 - 26,555,206 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	22,398,067 - 22,450,381 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	22,418,181 - 22,469,924 (+)	NCBI
Celera	7	17,456,470 - 17,507,229 (+)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

COVID-19 (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

non-alcoholic fatty liver disease (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-alpha-phellandrene (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

10-formyltetrahydrofolic acid (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

4,4'-diaminodiphenylmethane (EXP,ISO)

5,6,7,8-tetrahydrofolic acid (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

antimycin A (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

carbon nanotube (ISO)

choline (ISO)

chromium trinitrate (ISO)

clobetasol (ISO)

cobalt atom (ISO)

cobalt dichloride (EXP)

copper atom (EXP)

copper(0) (EXP)

Cuprizon (EXP)

cyclosporin A (ISO)

dexamethasone (ISO)

diclofenac (ISO)

Didecyldimethylammonium (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethanol (ISO)

ferric oxide (ISO)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

hydroquinone (ISO)

indometacin (ISO)

iodide salt (EXP)

isobutanol (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead diacetate (ISO)

lucanthone (ISO)

mercury dibromide (ISO)

methapyrilene (ISO)

methylisothiazolinone (ISO)

methylmercury chloride (ISO)

Mitotane (ISO)

monosodium L-glutamate (ISO)

N-ethyl-N-nitrosourea (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodimethylamine (EXP)

nickel sulfate (ISO)

nitrofen (EXP)

oxaliplatin (EXP)

ozone (ISO)

panobinostat (ISO)

paraquat (EXP)

perfluorooctanoic acid (EXP,ISO)

phenylmercury acetate (ISO)

potassium chromate (ISO)

resveratrol (ISO)

rotenone (EXP,ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium dichromate (EXP)

Soman (EXP)

sulforaphane (ISO)

sunitinib (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichostatin A (ISO)

triptonide (ISO)

trovafloxacin (ISO)

Tungsten carbide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

10-formyltetrahydrofolate catabolic process (ISO)

biosynthetic process (IEA)

fatty acid beta-oxidation (ISO)

folic acid metabolic process (ISO)

NADPH regeneration (ISO)

one-carbon metabolic process (IEA)

Cellular Component

cytoplasm (IEA)

mitochondrion (ISO)

nucleoplasm (ISO)

Molecular Function

aldehyde dehydrogenase (NAD+) activity (IBA)

formyltetrahydrofolate dehydrogenase activity (IBA,ISO)

hydroxymethyl-, formyl- and related transferase activity (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

folate mediated one-carbon metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:18614015	PMID:20498374	PMID:21238436	PMID:23533145

Genomics

Comparative Map Data

Aldh1l2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	20,254,196 - 20,305,793 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	20,254,233 - 20,305,776 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	22,226,671 - 22,277,861 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	24,389,426 - 24,440,621 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	24,166,438 - 24,217,632 (+)	NCBI	Rnor_WKY
Rnor_6.0	7	26,375,866 - 26,425,838 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	26,375,866 - 26,425,108 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	26,506,321 - 26,555,206 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	22,398,067 - 22,450,381 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	22,418,181 - 22,469,924 (+)	NCBI
Celera	7	17,456,470 - 17,507,229 (+)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

ALDH1L2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	105,019,790 - 105,084,458 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	12	105,019,784 - 105,107,643 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	105,413,568 - 105,478,236 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	103,942,332 - 104,002,366 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	105,078,239 - 105,142,624 (-)	NCBI		Celera
Cytogenetic Map	12	q23.3	NCBI
HuRef	12	102,472,652 - 102,538,019 (-)	NCBI		HuRef
CHM1_1	12	105,379,314 - 105,443,992 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	104,981,395 - 105,046,228 (-)	NCBI		T2T-CHM13v2.0

Aldh1l2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	83,320,386 - 83,370,008 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	83,323,314 - 83,370,004 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	83,487,447 - 83,534,146 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	83,487,450 - 83,534,140 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	82,950,192 - 82,996,885 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	82,917,249 - 82,963,861 (-)	NCBI		MGSCv36	mm8
Celera	10	85,474,860 - 85,521,640 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI

Aldh1l2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	39,387,527 - 39,437,322 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955405	39,387,949 - 39,437,282 (-)	NCBI	ChiLan1.0	ChiLan1.0

ALDH1L2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	12	105,992,398 - 106,046,239 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	105,997,045 - 106,056,607 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	12	102,596,881 - 102,661,617 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

ALDH1L2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	33,310,523 - 33,365,677 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	33,310,558 - 33,365,228 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	33,229,898 - 33,285,026 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	34,151,792 - 34,207,579 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	34,151,821 - 34,207,560 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	33,887,203 - 33,942,545 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	34,171,323 - 34,226,449 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	34,364,647 - 34,420,074 (+)	NCBI		UU_Cfam_GSD_1.0

Aldh1l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	16,595,327 - 16,651,070 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	9,605,708 - 9,657,743 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936492	9,605,611 - 9,657,717 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALDH1L2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	79,492,750 - 79,558,701 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	79,492,672 - 79,558,702 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	82,894,904 - 82,954,624 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ALDH1L2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	100,242,649 - 100,311,164 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	100,247,262 - 100,298,621 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	144,713,789 - 144,779,293 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aldh1l2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624750	3,912,002 - 3,961,963 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624750	3,912,030 - 4,054,170 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Aldh1l2
483 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	468
Count of miRNA genes:	163
Interacting mature miRNAs:	187
Transcripts:	ENSRNOT00000059639, ENSRNOT00000072587, ENSRNOT00000075809
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	27829089	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	664270	26029351	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
10755438	Coatc9	Coat color QTL 9		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	3529280	48529280	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	5329019	50329019	Rat
10755440	Coatc10	Coat color QTL 10		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	7496499	52496499	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	7573985	52573985	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	9462246	58265113	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	9866467	60460686	Rat
738033	Anxrr6	Anxiety related response QTL 6	4.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	7	15573889	60573889	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
2317059	Aia15	Adjuvant induced arthritis QTL 15	2.46		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	17004598	62004598	Rat
10755451	Coatc11	Coat color QTL 11		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	17944357	62944357	Rat
70207	Niddm31	Non-insulin dependent diabetes mellitus QTL 31	3.9		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	18169505	26029351	Rat
61369	Mcs2	Mammary carcinoma susceptibility QTL 2	3.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	19032807	35526300	Rat
1354637	Scl30	Serum cholesterol level QTL 30	3.7		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	7	19654317	49753746	Rat
1354644	Spl4	Serum phospholipid level QTL 4	4.9		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	7	19654317	49753746	Rat
1354639	Spl5	Serum phospholipid level QTL 5	3.9		blood LDL phospholipid amount (VT:0010505)	blood low density lipoprotein phospholipid level (CMO:0001568)	7	19654317	52888450	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	19654317	84928080	Rat

Markers in Region

RH130819

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	20,305,327 - 20,305,530 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	26,425,507 - 26,425,709	NCBI	Rnor6.0
Rnor_5.0	7	26,554,875 - 26,555,077	UniSTS	Rnor5.0
RGSC_v3.4	7	22,450,050 - 22,450,252	UniSTS	RGSC3.4
Celera	7	17,506,898 - 17,507,100	UniSTS
RH 3.4 Map	7	117.95	UniSTS
Cytogenetic Map	7	q13	UniSTS

AU049799

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	20,293,717 - 20,293,850 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	26,414,306 - 26,414,438	NCBI	Rnor6.0
Rnor_5.0	7	26,543,674 - 26,543,806	UniSTS	Rnor5.0
RGSC_v3.4	7	22,438,220 - 22,438,352	UniSTS	RGSC3.4
Celera	7	17,495,138 - 17,495,270	UniSTS
Cytogenetic Map	7	q13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			25	25		25			41		5
Low	3	37	31	16	14	16	6	9	22	22	35	8	6
Below cutoff		6	1		5		2	2	11	13	1	3	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191778	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001414921	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078682	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000059639 ⟹ ENSRNOP00000056394

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	20,262,671 - 20,303,079 (+)	Ensembl
Rnor_6.0 Ensembl	7	26,375,866 - 26,425,108 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099798 ⟹ ENSRNOP00000077904

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	20,254,306 - 20,305,775 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000118245 ⟹ ENSRNOP00000080990

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	20,254,233 - 20,305,776 (+)	Ensembl

RefSeq Acc Id:

NM_001191778 ⟹ NP_001178707

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	20,254,314 - 20,305,659 (+)	NCBI
Rnor_6.0	7	26,375,866 - 26,425,838 (+)	NCBI
Rnor_5.0	7	26,506,321 - 26,555,206 (+)	NCBI
Celera	7	17,456,470 - 17,507,229 (+)	NCBI

Sequence:

show sequence

ATGCTGTGGCGGGGTAGCCAGGCGCTACGGCACTTCTCCACCGGCCGGGTTTATTTCAAAAACA
AGTTGAAGTTGGCACTTATTGGCCAGAGCCTGTTTGGACAGGAAGTCTACAGCCACCTCCTGAA
AGAGGGTCACCGAGTAGTGGGAGTGTTCACAGTGCCAGACAAGGATGGAAAGGCCGATCCACTG
GCTTTGGCCGCAGAGAAAGATGGGACCCCTGTGTTCAAGTTCCCTCGATGGAGAGTCAAGGGTA
AAACCATCAAGGAGGTAGCAGAAGCCTATCAGTCGGTAGGTGCTGAGCTCAACGTGCTTCCCTT
CTGCACGCAGTTCATCCCCATGGACATCATCGACAGCCCAGAGCACGGCTCCATCATCTACCAC
CCCTCACTCCTACCCAGGCACAGAGGGGCTTCTGCCATCAACTGGACTCTAATCATGGGAGATA
AGAAAGCTGGGTTTTCTGTTTTCTGGGCAGATGATGGTTTAGATACAGGACCCATCCTTCTTCA
GAGATCGTGTGACGTCAAACCCAATGACACAGTGGACTCGCTTTATAACCGGTTCCTTTTTCCT
GAGGGGATCAAGGCCATGGTAGAAGCTGTCCAACTCATAGCTGATGGAAAGGCGCCTCGCACTC
CCCAGCCGGAAGAGGGGGCCACATATGAAGGCATCCAGAAGAAGGAAAACGCTGAGATTCCTTG
GGACCAGCCTGCTGAAGTTTTGCACAACTGGATTCGAGGTCATGATAAGGTCCCTGGAGCCTGG
GCAGAGATAGACGGACAGATGGTGACTTTCTACGGCTCATCACTGTTGACAAGTTCTGTGCCTG
CTGGAGAACCACTGGACATTAGAGGTGCCAAGAAGCCTGGTCTTGTCACCAAAAATGGCCTTGT
TCTTTTTGGGAATGATGGGAAAGCGCTGATGGTGAGAAACCTGCAGTTTGAAGACGGGAAGATG
ATTCCCGCCTCCCAGTACTTTTCGTCGGGTGAGACATCGGTGGTAGAACTTACGGCTGAGGAGC
TGAAGGTGGCAGAGACCATAAAGGTCATCTGGGCTAGAATCTTAAGCAACGTCCCAGTGATTGA
GGACTCCACGGACTTCTTTAAATCTGGAGCGAGCTCAATGGATGTTGCGAGGCTGGTGGAAGAG
ATCAGACAGAAGTGCGGTGGGCTTCAGCTGCAGAACGAAGATGTCTACATGGCCCGCAAGTTTG
GAGATTTCATCCAAAAGGTTGTGAGGAGACTAAGAGGAGAGGACCAAGAGGCTGAGCTGGTGGT
GGATTATGTTTCCAAGGAGGTAAACGAGATGACAGTGAAGATGCCCTACCAGTGTTTCATAAAC
GGACAGTTTGTAGATGCCGAGGATGGAGAGACTTACGCCACCATCAACCCCACAGACGGAACTA
CGCTATGCAGAGTGTCCTACGCTTCTTTAGCGGATGTTGACAGAGCAGTAGCCGCGGCCAAGGA
CGCCTTTGAGAATGGCGAATGGGGAAGGATGAACGCCAGGGACAGAGGAAGACTCATGTACAGA
CTCGCGGACCTAATGGAAGAAAACCAGGAGGAGCTGGCGACCATAGAAGCGCTGGATTCCGGGG
CTGTCTACACCCTGGCTCTGAAGACTCATATTGGAATGTCCGTGCAGACCTTCAGATACTTCGC
AGGCTGGTGTGACAAAATTCAGGTAACAAAGGAACCAGAGAACCAGGCTAGAATTCATGACACT
CTGGGGATGAGCTCGGAAGAACCAAAAGGTGTCTGCGCCATCATCATTCCCTGGAACTACCCAC
TAATGATGCTGGCCTGGAAGAGTGCAGCCTGCCTGGCAGCAGGCAACACCCTAGTACTCAAGCC
AGCGCAGGTCACACCCTTGACAGCTCTGAAGTTTGCAGAGCTGACGGTGAAAGCAGGCTTTCCG
AAGGGGGTAATCAACATCATTCCTGGCTCAGGGGGTGTGGCAGGACAGCGGCTCTCTCAGCACC
CTGACATCCGCAAGCTTGGTTTCACTGGTTCCACCTCTGTGGGCAAACAGATCATGAAAAGCTG
TGCTGTGAGCAACCTGAAGAAAGTTTCCCTTGAGCTTGGTGGCAAATCCCCACTTATAATATTC
AGCGACTGTGAACTTGACAAGGCCGTCCGGATGGGCATGGGCGCAGTATTCTTCAATAAAGGAG
AGAACTGCATTGCAGCTGGCCGGCTGTTCGTGGAAGAGGCCATCCACGATGAATTCGTCACCAG
AGTGGTGGAAGAGATTAAAAAGATGAAAATTGGTGATCCCCTGGACAGATCTACGGACCACGGG
CCCCAGAACCACAAAGCCCATTTGGAAAAGCTGCTGCAGTACTGCGAGACGGGGGTGAAGGAGG
GGGCCACACTGGTGTACGGAGGAAGACAGGTACAGAGGCCAGGCTTTTTCATGGAGCCCACTGT
GTTCACAGGCGTGGAGGACCACATGTACCTCGCCAAAGAGGAATCCTTCGGGCCTATCATGGTC
ATCTCTAAATTCCAAAATGGGGACATCGATGGGGTGCTGCAGAGAGCAAACAACACTGAGTACG
GCCTGGCCTCAGGGGTCTTCACGAGAGACATCAGCAAAGCCATGTACGTGAGTGACAGGCTAGA
GGCGGGAACGGTTTTCATTAACACCTACAACAAGACGGACGTGGCAGCCCCATTTGGTGGAGTG
AAGCAGTCTGGCTTTGGAAAAGACTTAGGTGAGGAGGCCCTGAACGAATACCTGAAAACCAAAA
CAGTGACCCTCGAGTATTAGAGAGACGCATCAGGAAACCTGTGACCAACAGCCCGCTTCTCAAC
TCTTCACAAGCTGAAAACCCCAACGGTGCTGAGGAAGCAGGGGCCGTCTGGAAGTAGATAAAAG
AATCAGGAAGAGGGTGTGACCACTTGTGTGAGCATTTACCTGACTAAGGGCCTCAAAAAAATTC
CAGGACACTGTTTATAACCAAATGACTTAACTCTTTTTAAAAATGTTGGTGGTGTATGTTTTTC
TAAAGTATCAAAGGTCCCTCCCCTTCCTCCCTGAATGTCTATTCGCTCCCAGGTCACCCATCTT
GAACACGCTGACCTCACTCACAGGCCCACTTAAGAAGAGTTCTGGGTCTCAACTCCCAAGCCGT
ATATACTGAACACTGTTAACCCTTTCTTTAGCTGTGCGTTCAAACAACAGGGTATCCTACAGAG
AACATAATGCCCGTCCTCGTCCCTTCTCGTATTAGAAGGAAGACTCATCTCTGTGCCTTTGACT
ATTATGTAACCTACTCTGACAAACGGGCAGCTCGTGAGCCTTTCTTCCACATCTTCCTACGTGG
TACAAAGGACTGTTAAGTTCAGAGGGCACCAAATTACTGACATCACCTTCGATACTGTAGTTTA
AATCCTGGTAAACTAACTGTGATGGCCAATCCCTGTCATACTACACCGGCTTACTGTGTGAGCT
GGGGGAAACTACCCAACTTGTCTGAGCTCTGGCCTCCTCATGTGTT

hide sequence

RefSeq Acc Id:

XM_039078682 ⟹ XP_038934610

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	20,254,196 - 20,305,793 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001178707	(Get FASTA)	NCBI Sequence Viewer
	NP_001401850	(Get FASTA)	NCBI Sequence Viewer
	XP_038934610	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM17081	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001178707 ⟸ NM_001191778

- Sequence:

show sequence

MLWRGSQALRHFSTGRVYFKNKLKLALIGQSLFGQEVYSHLLKEGHRVVGVFTVPDKDGKADPL
ALAAEKDGTPVFKFPRWRVKGKTIKEVAEAYQSVGAELNVLPFCTQFIPMDIIDSPEHGSIIYH
PSLLPRHRGASAINWTLIMGDKKAGFSVFWADDGLDTGPILLQRSCDVKPNDTVDSLYNRFLFP
EGIKAMVEAVQLIADGKAPRTPQPEEGATYEGIQKKENAEIPWDQPAEVLHNWIRGHDKVPGAW
AEIDGQMVTFYGSSLLTSSVPAGEPLDIRGAKKPGLVTKNGLVLFGNDGKALMVRNLQFEDGKM
IPASQYFSSGETSVVELTAEELKVAETIKVIWARILSNVPVIEDSTDFFKSGASSMDVARLVEE
IRQKCGGLQLQNEDVYMARKFGDFIQKVVRRLRGEDQEAELVVDYVSKEVNEMTVKMPYQCFIN
GQFVDAEDGETYATINPTDGTTLCRVSYASLADVDRAVAAAKDAFENGEWGRMNARDRGRLMYR
LADLMEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQVTKEPENQARIHDT
LGMSSEEPKGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELTVKAGFP
KGVINIIPGSGGVAGQRLSQHPDIRKLGFTGSTSVGKQIMKSCAVSNLKKVSLELGGKSPLIIF
SDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEEAIHDEFVTRVVEEIKKMKIGDPLDRSTDHG
PQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTGVEDHMYLAKEESFGPIMV
ISKFQNGDIDGVLQRANNTEYGLASGVFTRDISKAMYVSDRLEAGTVFINTYNKTDVAAPFGGV
KQSGFGKDLGEEALNEYLKTKTVTLEY

hide sequence

RefSeq Acc Id:

ENSRNOP00000056394 ⟸ ENSRNOT00000059639

RefSeq Acc Id:	XP_038934610 ⟸ XM_039078682
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000080990 ⟸ ENSRNOT00000118245

RefSeq Acc Id:

ENSRNOP00000077904 ⟸ ENSRNOT00000099798

Protein Domains

Carrier

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZTP0-F1-model_v2	AlphaFold	D3ZTP0	1-922	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695107

Promoter ID:

EPDNEW_R5632

Type:

initiation region

Name:

Aldh1l2_1

Description:

aldehyde dehydrogenase 1 family, member L2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	26,375,798 - 26,375,858	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309458	AgrOrtholog
BioCyc Gene	G2FUF-34587	BioCyc
Ensembl Genes	ENSRNOG00000008586	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000056394.5	UniProtKB/TrEMBL
	ENSRNOP00000077904.1	UniProtKB/TrEMBL
	ENSRNOP00000080990	ENTREZGENE
	ENSRNOP00000080990.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000059639.6	UniProtKB/TrEMBL
	ENSRNOT00000099798.1	UniProtKB/TrEMBL
	ENSRNOT00000118245	ENTREZGENE
	ENSRNOT00000118245.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1200.10	UniProtKB/TrEMBL
	3.10.25.10	UniProtKB/TrEMBL
	Formyl transferase, N-terminal domain	UniProtKB/TrEMBL
InterPro	10_FTHF_DH	UniProtKB/TrEMBL
	ACP-like_sf	UniProtKB/TrEMBL
	Acyl_carrier_prot-like	UniProtKB/TrEMBL
	Ald_DH/histidinol_DH	UniProtKB/TrEMBL
	Ald_DH_C	UniProtKB/TrEMBL
	Ald_DH_CS	UniProtKB/TrEMBL
	Ald_DH_CS_GLU	UniProtKB/TrEMBL
	Ald_DH_N	UniProtKB/TrEMBL
	Aldehyde_DH_dom	UniProtKB/TrEMBL
	Formyl_trans_C	UniProtKB/TrEMBL
	Formyl_trans_C_sf	UniProtKB/TrEMBL
	Formyl_transf_N	UniProtKB/TrEMBL
	Formyl_transf_N_sf	UniProtKB/TrEMBL
	Formyl_transferase_C-like	UniProtKB/TrEMBL
	GART_AS	UniProtKB/TrEMBL
	PPantetheine_attach_site	UniProtKB/TrEMBL
NCBI Gene	299699	ENTREZGENE
PANTHER	ALDEHYDE DEHYDROGENASE-RELATED	UniProtKB/TrEMBL
	MITOCHONDRIAL 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE	UniProtKB/TrEMBL
Pfam	Aldedh	UniProtKB/TrEMBL
	Formyl_trans_C	UniProtKB/TrEMBL
	Formyl_trans_N	UniProtKB/TrEMBL
	PP-binding	UniProtKB/TrEMBL
PhenoGen	Aldh1l2	PhenoGen
PIRSF	10-FTHFDH	UniProtKB/TrEMBL
PROSITE	ACP_DOMAIN	UniProtKB/TrEMBL
	ALDEHYDE_DEHYDR_CYS	UniProtKB/TrEMBL
	ALDEHYDE_DEHYDR_GLU	UniProtKB/TrEMBL
	GART	UniProtKB/TrEMBL
	PHOSPHOPANTETHEINE	UniProtKB/TrEMBL
Superfamily-SCOP	ACP_like	UniProtKB/TrEMBL
	Aldehyde_DH/Histidinol_DH	UniProtKB/TrEMBL
	FMT_C_like	UniProtKB/TrEMBL
	formyl_transf	UniProtKB/TrEMBL
UniProt	A0A8I5ZJL8_RAT	UniProtKB/TrEMBL
	A0A8I5ZRH3	ENTREZGENE, UniProtKB/TrEMBL
	D3ZTP0_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Aldh1l2	aldehyde dehydrogenase 1 family, member L2	Aldh1l2_predicted	aldehyde dehydrogenase 1 family, member L2 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Aldh1l2_predicted	aldehyde dehydrogenase 1 family, member L2 (predicted)	RGD1309458_predicted	similar to RIKEN cDNA D330038I09 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-20	RGD1309458_predicted	similar to RIKEN cDNA D330038I09 (predicted)	LOC299699_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC299699_predicted	similar to RIKEN cDNA D330038I09 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

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InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)

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Imported Annotations - KEGG (archival)