Pan2 (poly(A) specific ribonuclease subunit PAN2) - Rat Genome Database

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Gene: Pan2 (poly(A) specific ribonuclease subunit PAN2) Rattus norvegicus
Analyze
Symbol: Pan2
Name: poly(A) specific ribonuclease subunit PAN2
RGD ID: 1303301
Description: Predicted to enable 3'-5'-RNA exonuclease activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be located in nucleus. Predicted to be part of PAN complex. Predicted to be active in P-body. Orthologous to human PAN2 (poly(A) specific ribonuclease subunit PAN2); PARTICIPATES IN microRNA pathway; RNA degradation pathway; INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inactive ubiquitin carboxyl-terminal hydrolase 52; PAB-dependent poly(A)-specific ribonuclease subunit 2; PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAB1P-dependent poly(A)-specific ribonuclease; PAN deadenylation complex catalytic subunit 2; PAN deadenylation complex subunit 2; PAN2 poly(A) specific ribonuclease subunit; PAN2 polyA specific ribonuclease subunit; PAN2 polyA specific ribonuclease subunit homolog; PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae); PAN2-PAN3 deadenylation complex catalytic subunit Pan2; poly(A)-nuclease deadenylation complex subunit 2; ubiquitin specific peptidase 52; ubiquitin specific protease 52; Usp52
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,313,654 - 1,332,252 (+)NCBIGRCr8
mRatBN7.27729,146 - 747,744 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7729,562 - 747,744 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,485,392 - 3,506,344 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,361,374 - 5,382,326 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,664,033 - 5,682,875 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,717,021 - 2,736,541 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,718,700 - 2,736,157 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,696,488 - 2,714,954 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,592,319 - 1,609,170 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,592,318 - 1,609,170 (+)NCBI
Celera7605,467 - 622,256 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pan2Ratcataract 15 multiple types  ISOPAN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Cataract 15 multiple typesClinVarPMID:28492532
Pan2RatCharcot-Marie-Tooth disease axonal type 2U  ISOPAN2 (Homo sapiens)8554872ClinVar Annotator: match by term: CHARCOT-MARIE-TOOTH DISEASE more ...ClinVarPMID:28492532
Pan2RatINTERSTITIAL LUNG AND LIVER DISEASE  ISOPAN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Interstitial lung and liver diseaseClinVarPMID:28492532
Pan2Ratparaplegia  ISOPAN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegiaClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pan2RatChemical and Drug Induced Liver Injury  ISOPAN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26881866
Pan2Ratcholestasis  ISOPAN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26881866

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pan2Rat1,2-dimethylhydrazine multiple interactionsISOPan2 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of PAN2 mRNACTDPMID:22206623
Pan2Rat17alpha-ethynylestradiol affects expressionISOPan2 (Mus musculus)6480464Ethinyl Estradiol affects the expression of PAN2 mRNACTDPMID:17555576
Pan2Rat17alpha-ethynylestradiol multiple interactionsISOPan2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PAN2 mRNACTDPMID:17942748
Pan2Rat17alpha-ethynylestradiol increases expressionISOPan2 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of PAN2 mRNACTDPMID:17942748
Pan2Rat17beta-estradiol decreases expressionISOPAN2 (Homo sapiens)6480464Estradiol results in decreased expression of PAN2 mRNACTDPMID:31614463
Pan2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPan2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PAN2 mRNACTDPMID:17942748
Pan2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPan2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PAN2 mRNACTDPMID:21570461
Pan2Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of PAN2 mRNACTDPMID:21346803
Pan2Ratacrolein multiple interactionsISOPAN2 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of PAN2 mRNA more ...CTDPMID:32699268 and PMID:32845096
Pan2Rataflatoxin B1 affects expressionISOPAN2 (Homo sapiens)6480464Aflatoxin B1 affects the expression of PAN2 proteinCTDPMID:20106945
Pan2Rataflatoxin B1 increases methylationISOPAN2 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of PAN2 geneCTDPMID:27153756
Pan2Ratalpha-pinene multiple interactionsISOPAN2 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of PAN2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of PAN2 mRNACTDPMID:32699268
Pan2Rataristolochic acid A decreases expressionISOPAN2 (Homo sapiens)6480464aristolochic acid I results in decreased expression of PAN2 mRNACTDPMID:33212167
Pan2RatAroclor 1254 decreases expressionISOPan2 (Mus musculus)6480464Chlorodiphenyl (54% Chlorine) results in decreased expression of PAN2 mRNACTDPMID:23650126
Pan2Ratarsenous acid decreases expressionISOPAN2 (Homo sapiens)6480464Arsenic Trioxide results in decreased expression of PAN2 mRNACTDPMID:27829220
Pan2Ratbenzo[a]pyrene increases expressionISOPan2 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of PAN2 mRNACTDPMID:22228805
Pan2Ratbenzo[a]pyrene decreases methylationISOPAN2 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of PAN2 3' UTRCTDPMID:27901495
Pan2Ratbenzo[a]pyrene decreases expressionISOPAN2 (Homo sapiens)6480464Benzo(a)pyrene results in decreased expression of PAN2 mRNACTDPMID:26238291
Pan2Ratbeta-lapachone decreases expressionISOPAN2 (Homo sapiens)6480464beta-lapachone results in decreased expression of PAN2 mRNACTDPMID:38218311
Pan2Ratbis(2-ethylhexyl) phthalate decreases expressionISOPAN2 (Homo sapiens)6480464Diethylhexyl Phthalate results in decreased expression of PAN2 mRNACTDPMID:31163220

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Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pan2Ratbiological_process  ND 159840702/2016: no relevant rat dataRGD 
Pan2RatmRNA processing involved_inIEAUniProtKB-KW:KW-05071600115GO_REF:0000043UniProtGO_REF:0000043
Pan2Ratnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay involved_inIEAUniRule:UR0001661261600115GO_REF:0000104UniProtGO_REF:0000104
Pan2Ratnuclear-transcribed mRNA poly(A) tail shortening involved_inIEAUniRule:UR0001661261600115GO_REF:0000104UniProtGO_REF:0000104
Pan2Ratnuclear-transcribed mRNA poly(A) tail shortening involved_inIBAFB:FBgn0033352 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pan2Ratnuclear-transcribed mRNA poly(A) tail shortening involved_inIEAInterPro:IPR0308431600115GO_REF:0000002InterProGO_REF:0000002
Pan2Ratpositive regulation of cytoplasmic mRNA processing body assembly involved_inIEAUniRule:UR0001661261600115GO_REF:0000104UniProtGO_REF:0000104

Cellular Component
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pan2Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Pan2Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Pan2Ratnucleus located_inIEAUniRule:UR0001661261600115GO_REF:0000104UniProtGO_REF:0000104
Pan2Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Pan2RatP-body located_inIEAUniProtKB-SubCell:SL-02301600115GO_REF:0000044UniProtGO_REF:0000044
Pan2RatP-body located_inIEAUniProtKB:Q8BGF7 and ensembl:ENSMUSP000001512161600115GO_REF:0000107EnsemblGO_REF:0000107
Pan2RatP-body located_inISOPan2 (Mus musculus)1624291 PMID:18625844RGDPMID:18625844
Pan2RatP-body is_active_inIBAMGI:1918984 and PANTHER:PTN0004046641600115GO_REF:0000033GO_CentralGO_REF:0000033
Pan2RatP-body located_inIEAUniRule:UR0001661261600115GO_REF:0000104UniProtGO_REF:0000104
Pan2RatPAN complex part_ofISSUniProtKB:Q504Q31600115GO_REF:0000024UniProtGO_REF:0000024
Pan2RatPAN complex part_ofIEAUniProtKB:Q504Q3 and ensembl:ENSP000003882311600115GO_REF:0000107EnsemblGO_REF:0000107
Pan2RatPAN complex part_ofIBAPANTHER:PTN000404664 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pan2RatPAN complex part_ofIEAInterPro:IPR0308431600115GO_REF:0000002InterProGO_REF:0000002
Pan2RatPAN complex part_ofISOPAN2 (Homo sapiens)1624291 PMID:14583602RGDPMID:14583602
Pan2RatPAN complex part_ofIEAUniRule:UR0001661261600115GO_REF:0000104UniProtGO_REF:0000104
1 to 15 of 15 rows

Molecular Function
1 to 17 of 17 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pan2Rat3'-5'-RNA exonuclease activity enablesISSUniProtKB:Q504Q31600115GO_REF:0000024UniProtGO_REF:0000024
Pan2Rat3'-5'-RNA exonuclease activity enablesIEAUniProtKB:Q504Q3 and ensembl:ENSP000003882311600115GO_REF:0000107EnsemblGO_REF:0000107
Pan2Rat3'-5'-RNA exonuclease activity enablesISOPAN2 (Homo sapiens)1624291 PMID:14583602RGDPMID:14583602
Pan2Ratexonuclease activity enablesIEAUniProtKB-KW:KW-02691600115GO_REF:0000043UniProtGO_REF:0000043
Pan2Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Pan2Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Pan2Ratnuclease activity enablesIEAUniProtKB-KW:KW-05401600115GO_REF:0000043UniProtGO_REF:0000043
Pan2Ratnucleic acid binding enablesIEAInterPro:IPR0363971600115GO_REF:0000002InterProGO_REF:0000002
Pan2Ratpoly(A)-specific ribonuclease activity enablesISOPAN2 (Homo sapiens)1624291 PMID:14583602RGDPMID:14583602
Pan2Ratpoly(A)-specific ribonuclease activity enablesIEAInterPro:IPR0308431600115GO_REF:0000002InterProGO_REF:0000002
Pan2Ratpoly(A)-specific ribonuclease activity enablesIEAUniProtKB:Q504Q3 and ensembl:ENSP000003882311600115GO_REF:0000107EnsemblGO_REF:0000107
Pan2Ratpoly(A)-specific ribonuclease activity contributes_toIBAPANTHER:PTN000404664 and SGD:S0000030621600115GO_REF:0000033GO_CentralGO_REF:0000033
Pan2Ratpoly(A)-specific ribonuclease activity enablesIEAEC:3.1.13.41600115GO_REF:0000003UniProtGO_REF:0000003
Pan2Ratpoly(A)-specific ribonuclease activity enablesIEAUniRule:UR0001661261600115GO_REF:0000104UniProtGO_REF:0000104
Pan2Ratpoly(A)-specific ribonuclease activity enablesISSUniProtKB:Q504Q31600115GO_REF:0000024UniProtGO_REF:0000024
Pan2Ratprotein binding enablesISOPAN2 (Homo sapiens)1624291UniProtKB:Q58A45 more ...RGDPMID:14583602 more ...
Pan2Ratprotein binding enablesISOPan2 (Mus musculus)1624291PR:Q640Q5 PMID:18625844RGDPMID:18625844
1 to 17 of 17 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pan2RatmicroRNA pathway   ISOPAN2 (Homo sapiens)9850101 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pan2RatRNA degradation pathway  IEA 6907045 KEGGrno:03018

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes. Wahle E and Winkler GS, Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):561-70. doi: 10.1016/j.bbagrm.2013.01.003. Epub 2013 Jan 19.
PMID:14583602   PMID:15057822   PMID:18625844  



Pan2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,313,654 - 1,332,252 (+)NCBIGRCr8
mRatBN7.27729,146 - 747,744 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7729,562 - 747,744 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,485,392 - 3,506,344 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,361,374 - 5,382,326 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,664,033 - 5,682,875 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,717,021 - 2,736,541 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,718,700 - 2,736,157 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,696,488 - 2,714,954 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,592,319 - 1,609,170 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,592,318 - 1,609,170 (+)NCBI
Celera7605,467 - 622,256 (+)NCBICelera
Cytogenetic Map7q11NCBI
PAN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,316,936 - 56,334,000 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,316,223 - 56,334,053 (-)EnsemblGRCh38hg38GRCh38
GRCh371256,710,720 - 56,727,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,996,987 - 55,014,017 (-)NCBINCBI36Build 36hg18NCBI36
Build 341254,996,987 - 55,014,017NCBI
Celera1256,362,795 - 56,381,209 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1253,748,483 - 53,766,587 (-)NCBIHuRef
CHM1_11256,677,427 - 56,695,221 (-)NCBICHM1_1
T2T-CHM13v2.01256,284,581 - 56,301,646 (-)NCBIT2T-CHM13v2.0
Pan2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,135,106 - 128,157,227 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,139,204 - 128,157,227 (+)EnsemblGRCm39 Ensembl
GRCm3810128,303,333 - 128,321,358 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,303,335 - 128,321,358 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,740,391 - 127,758,403 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,706,284 - 127,724,296 (+)NCBIMGSCv36mm8
Celera10130,691,647 - 130,709,640 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.51NCBI
Pan2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,926,070 - 3,941,506 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,925,356 - 3,946,879 (-)NCBIChiLan1.0ChiLan1.0
PAN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,998,405 - 38,015,142 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,995,171 - 38,011,908 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,581,728 - 32,598,445 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,835,235 - 32,853,645 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,835,235 - 32,853,645 (+)Ensemblpanpan1.1panPan2
PAN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110621,286 - 636,899 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10621,281 - 634,495 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10684,704 - 700,375 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010629,926 - 645,778 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10629,929 - 644,050 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110607,360 - 623,030 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010850,333 - 866,183 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010974,230 - 989,907 (-)NCBIUU_Cfam_GSD_1.0
Pan2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,132,918 - 58,150,435 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646720,393 - 736,467 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646719,821 - 737,284 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,712,261 - 21,727,903 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,712,222 - 21,730,528 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,190,220 - 23,204,911 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,273,867 - 52,290,514 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,274,540 - 52,289,410 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,696,302 - 193,713,450 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pan2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,669,908 - 11,686,122 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,668,977 - 11,686,840 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Pan2
57 total Variants

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:82
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000050792
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 16 of 16 rows
RefSeq Transcripts NM_001395705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001395706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENSRNOT00000050792   ⟹   ENSRNOP00000039314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7729,562 - 747,744 (+)Ensembl
Rnor_6.0 Ensembl72,718,700 - 2,736,157 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097010   ⟹   ENSRNOP00000089136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7729,562 - 746,870 (+)Ensembl
RefSeq Acc Id: NM_001395705   ⟹   NP_001382634
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,313,655 - 1,332,252 (+)NCBI
mRatBN7.27729,146 - 747,744 (+)NCBI
RefSeq Acc Id: NM_001395706   ⟹   NP_001382635
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,313,655 - 1,332,252 (+)NCBI
mRatBN7.27729,146 - 747,744 (+)NCBI
RefSeq Acc Id: XM_006240785   ⟹   XP_006240847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,313,654 - 1,331,610 (+)NCBI
mRatBN7.27729,146 - 747,103 (+)NCBI
Rnor_6.072,717,021 - 2,735,915 (+)NCBI
Rnor_5.072,696,488 - 2,714,954 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240786   ⟹   XP_006240848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,313,654 - 1,332,252 (+)NCBI
mRatBN7.27729,146 - 747,744 (+)NCBI
Rnor_6.072,717,021 - 2,736,541 (+)NCBI
Rnor_5.072,696,488 - 2,714,954 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240787   ⟹   XP_006240849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,313,654 - 1,332,252 (+)NCBI
mRatBN7.27729,146 - 747,744 (+)NCBI
Rnor_6.072,717,021 - 2,736,541 (+)NCBI
Rnor_5.072,696,488 - 2,714,954 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240788   ⟹   XP_006240850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,313,654 - 1,332,252 (+)NCBI
mRatBN7.27729,146 - 747,744 (+)NCBI
Rnor_6.072,717,021 - 2,736,541 (+)NCBI
Rnor_5.072,696,488 - 2,714,954 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240789   ⟹   XP_006240851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,313,654 - 1,332,252 (+)NCBI
mRatBN7.27729,146 - 747,744 (+)NCBI
Rnor_6.072,717,021 - 2,736,541 (+)NCBI
Rnor_5.072,696,488 - 2,714,954 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039079715   ⟹   XP_038935643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,314,566 - 1,332,252 (+)NCBI
mRatBN7.27729,182 - 747,744 (+)NCBI
RefSeq Acc Id: XM_063264087   ⟹   XP_063120157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,313,654 - 1,332,252 (+)NCBI
RefSeq Acc Id: XM_063264088   ⟹   XP_063120158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,313,654 - 1,332,252 (+)NCBI
RefSeq Acc Id: XR_005486693
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,313,654 - 1,327,469 (+)NCBI
mRatBN7.27729,146 - 742,964 (+)NCBI
RefSeq Acc Id: XR_005486694
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,313,654 - 1,325,995 (+)NCBI
mRatBN7.27729,146 - 742,185 (+)NCBI
1 to 5 of 12 rows
1 to 5 of 12 rows
RefSeq Acc Id: XP_006240850   ⟸   XM_006240788
- Peptide Label: isoform X4
- UniProtKB: Q6IE70 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006240848   ⟸   XM_006240786
- Peptide Label: isoform X2
- UniProtKB: Q6IE70 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006240849   ⟸   XM_006240787
- Peptide Label: isoform X3
- UniProtKB: Q6IE70 (UniProtKB/Swiss-Prot),   R9PXX6 (UniProtKB/TrEMBL),   A6KSB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240851   ⟸   XM_006240789
- Peptide Label: isoform X7
- UniProtKB: Q6IE70 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006240847   ⟸   XM_006240785
- Peptide Label: isoform X1
- UniProtKB: Q6IE70 (UniProtKB/Swiss-Prot)
- Sequence:
Exonuclease   USP

Name Modeler Protein Id AA Range Protein Structure
AF-Q6IE70-F1-model_v2 AlphaFold Q6IE70 1-1205 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 35 of 35 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-35378 BioCyc
Ensembl Genes ENSRNOG00000032441 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000050792 ENTREZGENE
  ENSRNOT00000097010 ENTREZGENE
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot
  3.30.420.10 UniProtKB/Swiss-Prot
  Cysteine proteinases UniProtKB/Swiss-Prot
InterPro Exonuclease_RNaseT/DNA_pol3 UniProtKB/Swiss-Prot
  PAN2 UniProtKB/Swiss-Prot
  PAN2-PAN3_catalytic_subunit UniProtKB/Swiss-Prot
  PAN2_dom UniProtKB/Swiss-Prot
  PAN2_N UniProtKB/Swiss-Prot
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  RNaseH-like_sf UniProtKB/Swiss-Prot
  RNaseH_sf UniProtKB/Swiss-Prot
  USP_dom UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot
NCBI Gene 408200 ENTREZGENE
PANTHER DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2 UniProtKB/Swiss-Prot
  PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2 UniProtKB/Swiss-Prot
Pfam PAN2_N UniProtKB/Swiss-Prot
  RNase_T UniProtKB/Swiss-Prot
  UCH_1 UniProtKB/Swiss-Prot
PhenoGen Pan2 PhenoGen
PROSITE USP_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032441 RatGTEx
SMART EXOIII UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot
  SSF53098 UniProtKB/Swiss-Prot
  SSF54001 UniProtKB/Swiss-Prot
UniProt A0A8I6GGY1_RAT UniProtKB/TrEMBL
  A6KSB7 ENTREZGENE, UniProtKB/TrEMBL
  PAN2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  R9PXX6 ENTREZGENE, UniProtKB/TrEMBL
1 to 35 of 35 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-04 Pan2  poly(A) specific ribonuclease subunit PAN2  Pan2  PAN2 poly(A) specific ribonuclease subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-04-11 Pan2  PAN2 poly(A) specific ribonuclease subunit  Pan2  PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Pan2  PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)  Usp52  ubiquitin specific peptidase 52  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Usp52  ubiquitin specific peptidase 52  Usp52  ubiquitin specific protease 52  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Usp52  ubiquitin specific protease 52      Symbol and Name status set to approved 1299863 APPROVED
2005-07-14 Usp52  ubiquitin specific protease 52      Symbol and Name status set to provisional 70820 PROVISIONAL