PAN2 (poly(A) specific ribonuclease subunit PAN2) - Rat Genome Database

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Gene: PAN2 (poly(A) specific ribonuclease subunit PAN2) Pan paniscus
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Symbol: PAN2
Name: poly(A) specific ribonuclease subunit PAN2
RGD ID: 11863860
Description: ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); exonuclease activity (inferred); metal ion binding (inferred); INVOLVED IN mRNA processing (inferred); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (inferred); nuclear-transcribed mRNA poly(A) tail shortening (inferred); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH cataract 15 multiple types (ortholog); Charcot-Marie-Tooth disease axonal type 2U (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); P-body (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAN2 poly(A) specific ribonuclease subunit; PAN2 poly(A) specific ribonuclease subunit homolog; PAN2-PAN3 deadenylation complex catalytic subunit PAN2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,998,405 - 38,015,142 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,995,171 - 38,011,908 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,581,728 - 32,598,445 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,835,235 - 32,853,645 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,835,235 - 32,853,645 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)
P-body  (IEA)
PAN complex  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PAN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,998,405 - 38,015,142 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,995,171 - 38,011,908 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,581,728 - 32,598,445 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,835,235 - 32,853,645 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,835,235 - 32,853,645 (+)Ensemblpanpan1.1panPan2
PAN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,316,936 - 56,334,000 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,316,223 - 56,334,053 (-)EnsemblGRCh38hg38GRCh38
GRCh371256,710,720 - 56,727,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,996,987 - 55,014,017 (-)NCBINCBI36Build 36hg18NCBI36
Build 341254,996,987 - 55,014,017NCBI
Celera1256,362,795 - 56,381,209 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1253,748,483 - 53,766,587 (-)NCBIHuRef
CHM1_11256,677,427 - 56,695,221 (-)NCBICHM1_1
T2T-CHM13v2.01256,284,581 - 56,301,646 (-)NCBIT2T-CHM13v2.0
Pan2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,135,106 - 128,157,227 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,139,204 - 128,157,227 (+)EnsemblGRCm39 Ensembl
GRCm3810128,303,333 - 128,321,358 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,303,335 - 128,321,358 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,740,391 - 127,758,403 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,706,284 - 127,724,296 (+)NCBIMGSCv36mm8
Celera10130,691,647 - 130,709,640 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.51NCBI
Pan2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,313,654 - 1,332,252 (+)NCBIGRCr8
mRatBN7.27729,146 - 747,744 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7729,562 - 747,744 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,485,392 - 3,506,344 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,361,374 - 5,382,326 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,664,033 - 5,682,875 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,717,021 - 2,736,541 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,718,700 - 2,736,157 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,696,488 - 2,714,954 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,592,319 - 1,609,170 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,592,318 - 1,609,170 (+)NCBI
Celera7605,467 - 622,256 (+)NCBICelera
Cytogenetic Map7q11NCBI
Pan2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,926,070 - 3,941,506 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,925,356 - 3,946,879 (-)NCBIChiLan1.0ChiLan1.0
PAN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110621,286 - 636,899 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10621,281 - 634,495 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10684,704 - 700,375 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010629,926 - 645,778 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10629,929 - 644,050 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110607,360 - 623,030 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010850,333 - 866,183 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010974,230 - 989,907 (-)NCBIUU_Cfam_GSD_1.0
Pan2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,132,918 - 58,150,435 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646720,393 - 736,467 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646719,821 - 737,284 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,712,261 - 21,727,903 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,712,222 - 21,730,528 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,190,220 - 23,204,911 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,273,867 - 52,290,514 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,274,540 - 52,289,410 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,696,302 - 193,713,450 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pan2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,669,908 - 11,686,122 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,668,977 - 11,686,840 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008978599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014347128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034935651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034935652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034935653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034935655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034935656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034935657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034935658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034935659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034935660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055095529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055095530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055095531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055095532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055095533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055095534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055095535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055095538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055095539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055095540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_057299424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063593420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004665662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000003015   ⟹   ENSPPAP00000000662
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1232,835,235 - 32,853,645 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000003073   ⟹   ENSPPAP00000000678
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1232,844,817 - 32,850,529 (+)Ensembl
RefSeq Acc Id: XM_008978599   ⟹   XP_008976847
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,998,405 - 38,015,142 (+)NCBI
NHGRI_mPanPan11237,995,171 - 38,011,908 (+)NCBI
Mhudiblu_PPA_v01232,581,730 - 32,598,445 (+)NCBI
PanPan1.11232,835,235 - 32,851,210 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014347128   ⟹   XP_014202614
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,998,405 - 38,015,142 (+)NCBI
NHGRI_mPanPan11237,995,171 - 38,011,908 (+)NCBI
Mhudiblu_PPA_v01232,581,730 - 32,598,445 (+)NCBI
PanPan1.11232,835,235 - 32,851,210 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034935658   ⟹   XP_034791549
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,998,409 - 38,015,142 (+)NCBI
NHGRI_mPanPan11237,995,175 - 38,011,908 (+)NCBI
Mhudiblu_PPA_v01232,581,730 - 32,598,445 (+)NCBI
RefSeq Acc Id: XM_055095529   ⟹   XP_054951504
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,998,409 - 38,015,142 (+)NCBI
NHGRI_mPanPan11237,995,176 - 38,011,908 (+)NCBI
RefSeq Acc Id: XM_055095530   ⟹   XP_054951505
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,998,579 - 38,015,142 (+)NCBI
NHGRI_mPanPan11237,995,457 - 38,011,908 (+)NCBI
RefSeq Acc Id: XM_055095531   ⟹   XP_054951506
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,998,691 - 38,015,142 (+)NCBI
NHGRI_mPanPan11237,995,457 - 38,011,908 (+)NCBI
RefSeq Acc Id: XM_055095532   ⟹   XP_054951507
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,998,676 - 38,015,142 (+)NCBI
NHGRI_mPanPan11237,995,442 - 38,011,908 (+)NCBI
RefSeq Acc Id: XM_055095533   ⟹   XP_054951508
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,998,474 - 38,015,142 (+)NCBI
NHGRI_mPanPan11237,995,251 - 38,011,908 (+)NCBI
RefSeq Acc Id: XM_055095534   ⟹   XP_054951509
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,998,691 - 38,015,142 (+)NCBI
NHGRI_mPanPan11237,995,457 - 38,011,908 (+)NCBI
RefSeq Acc Id: XM_055095535   ⟹   XP_054951510
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,998,474 - 38,015,142 (+)NCBI
NHGRI_mPanPan11237,995,247 - 38,011,908 (+)NCBI
RefSeq Acc Id: XM_055095538   ⟹   XP_054951513
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,998,405 - 38,015,142 (+)NCBI
NHGRI_mPanPan11237,995,171 - 38,011,908 (+)NCBI
RefSeq Acc Id: XM_055095539   ⟹   XP_054951514
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,998,409 - 38,015,142 (+)NCBI
NHGRI_mPanPan11237,995,176 - 38,011,908 (+)NCBI
RefSeq Acc Id: XM_055095540   ⟹   XP_054951515
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,998,405 - 38,015,142 (+)NCBI
NHGRI_mPanPan11237,995,171 - 38,011,908 (+)NCBI
RefSeq Acc Id: XM_057299424   ⟹   XP_057155407
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,998,691 - 38,015,142 (+)NCBI
NHGRI_mPanPan11237,995,457 - 38,011,908 (+)NCBI
RefSeq Acc Id: XM_063593420   ⟹   XP_063449490
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,998,409 - 38,015,142 (+)NCBI
RefSeq Acc Id: XP_014202614   ⟸   XM_014347128
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008976847   ⟸   XM_008978599
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_034791549   ⟸   XM_034935658
- Peptide Label: isoform X3
- UniProtKB: A0A2R8Z761 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000000662   ⟸   ENSPPAT00000003015
Ensembl Acc Id: ENSPPAP00000000678   ⟸   ENSPPAT00000003073
RefSeq Acc Id: XP_054951513   ⟸   XM_055095538
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054951515   ⟸   XM_055095540
- Peptide Label: isoform X8
RefSeq Acc Id: XP_054951504   ⟸   XM_055095529
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054951514   ⟸   XM_055095539
- Peptide Label: isoform X7
RefSeq Acc Id: XP_054951510   ⟸   XM_055095535
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054951508   ⟸   XM_055095533
- Peptide Label: isoform X3
- UniProtKB: A0A2R8Z761 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054951507   ⟸   XM_055095532
- Peptide Label: isoform X3
- UniProtKB: A0A2R8Z761 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054951505   ⟸   XM_055095530
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054951506   ⟸   XM_055095531
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054951509   ⟸   XM_055095534
- Peptide Label: isoform X4
RefSeq Acc Id: XP_057155407   ⟸   XM_057299424
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063449490   ⟸   XM_063593420
- Peptide Label: isoform X5
Protein Domains
USP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000001208 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000003015.1 UniProtKB/TrEMBL
  ENSPPAT00000003073.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  3.30.420.10 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/TrEMBL
InterPro Exonuclease_RNaseT/DNA_pol3 UniProtKB/TrEMBL
  PAN2 UniProtKB/TrEMBL
  PAN2-PAN3_catalytic_subunit UniProtKB/TrEMBL
  PAN2_dom UniProtKB/TrEMBL
  PAN2_N UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
  USP_dom UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene PAN2 ENTREZGENE
PANTHER DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2 UniProtKB/TrEMBL
  PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2 UniProtKB/TrEMBL
Pfam PAN2_N UniProtKB/TrEMBL
  RNase_T UniProtKB/TrEMBL
  UCH_1 UniProtKB/TrEMBL
PROSITE USP_3 UniProtKB/TrEMBL
SMART EXOIII UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
  SSF53098 UniProtKB/TrEMBL
  SSF54001 UniProtKB/TrEMBL
UniProt A0A2R8Z761 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8Z772_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 PAN2  poly(A) specific ribonuclease subunit PAN2    PAN2 poly(A) specific ribonuclease subunit  Symbol and/or name change 5135510 APPROVED