RGD Reference Report - RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes. - Rat Genome Database

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RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes.

Authors: Wahle, E  Winkler, GS 
Citation: Wahle E and Winkler GS, Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):561-70. doi: 10.1016/j.bbagrm.2013.01.003. Epub 2013 Jan 19.
RGD ID: 9850101
Pubmed: PMID:23337855   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbagrm.2013.01.003   (Journal Full-text)

Shortening and removal of the 3' poly(A) tail of mature mRNA by poly(A)-specific 3' exonucleases (deadenylases) is the initial and often rate-limiting step in mRNA degradation. The majority of cytoplasmic deadenylase activity is associated with the Ccr4-Not and Pan2-Pan3 complexes. Two distinct catalytic subunits, Caf1/Pop2 and Ccr4, are associated with the Ccr4-Not complex, whereas the Pan2 enzymatic subunit forms a stable complex with Pan3. In this review, we discuss the composition and activity of these two deadenylases. In addition, we comment on generic and specific mechanisms of recruitment of Ccr4-Not and Pan2-Pan3 to mRNAs. Finally, we discuss specialised and redundant functions of the deadenylases and review the importance of Ccr4-Not subunits in the regulation of physiological processes. This article is part of a Special Issue entitled: RNA Decay mechanisms.

Objects Annotated

Genes (Rattus norvegicus)
Cnot1  (CCR4-NOT transcription complex, subunit 1)
Cnot10  (CCR4-NOT transcription complex, subunit 10)
Cnot2  (CCR4-NOT transcription complex, subunit 2)
Cnot3  (CCR4-NOT transcription complex, subunit 3)
Cnot6  (CCR4-NOT transcription complex, subunit 6)
Cnot6l  (CCR4-NOT transcription complex, subunit 6-like)
Cnot7  (CCR4-NOT transcription complex, subunit 7)
Cnot8  (CCR4-NOT transcription complex, subunit 8)
Cnot9  (CCR4-NOT transcription complex subunit 9)
Pabpc1  (poly(A) binding protein, cytoplasmic 1)
Pan2  (poly(A) specific ribonuclease subunit PAN2)
Pan3  (poly(A) specific ribonuclease subunit PAN3)

Genes (Mus musculus)
Cnot1  (CCR4-NOT transcription complex, subunit 1)
Cnot10  (CCR4-NOT transcription complex, subunit 10)
Cnot2  (CCR4-NOT transcription complex, subunit 2)
Cnot3  (CCR4-NOT transcription complex, subunit 3)
Cnot6  (CCR4-NOT transcription complex, subunit 6)
Cnot6l  (CCR4-NOT transcription complex, subunit 6-like)
Cnot7  (CCR4-NOT transcription complex, subunit 7)
Cnot8  (CCR4-NOT transcription complex, subunit 8)
Cnot9  (CCR4-NOT transcription complex, subunit 9)
Pabpc1  (poly(A) binding protein, cytoplasmic 1)
Pan2  (PAN2 poly(A) specific ribonuclease subunit)
Pan3  (PAN3 poly(A) specific ribonuclease subunit)

Genes (Homo sapiens)
CNOT1  (CCR4-NOT transcription complex subunit 1)
CNOT10  (CCR4-NOT transcription complex subunit 10)
CNOT2  (CCR4-NOT transcription complex subunit 2)
CNOT3  (CCR4-NOT transcription complex subunit 3)
CNOT6  (CCR4-NOT transcription complex subunit 6)
CNOT6L  (CCR4-NOT transcription complex subunit 6 like)
CNOT7  (CCR4-NOT transcription complex subunit 7)
CNOT8  (CCR4-NOT transcription complex subunit 8)
CNOT9  (CCR4-NOT transcription complex subunit 9)
PABPC1  (poly(A) binding protein cytoplasmic 1)
PAN2  (poly(A) specific ribonuclease subunit PAN2)
PAN3  (poly(A) specific ribonuclease subunit PAN3)


Additional Information