CU-O LINKAGE - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	CU-O LINKAGE	go back to main search page
Accession:	CHEBI:47286	browse the term
Synonyms:	xref_mesh:	MESH:C030973

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Rat (530) Mouse (531) Human (569) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (530)

CU-O LINKAGE

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 10

decreases expression

cupric oxide results in decreased expression of ABCB10 mRNA

NCBI chr19:51,952,655...51,982,910
Ensembl chr19:51,952,681...51,982,753

G

ATP binding cassette subfamily F member 1

decreases expression

cupric oxide results in decreased expression of ABCF1 protein

NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433

G

acyl-CoA synthetase long-chain family member 3

increases expression

cupric oxide results in increased expression of ACSL3 protein

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

acyl-CoA synthetase long-chain family member 4

decreases expression

cupric oxide results in decreased expression of ACSL4 protein

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

actinin alpha 4

increases expression

cupric oxide results in increased expression of ACTN4 protein

NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847

G

actin related protein 3B

decreases expression

cupric oxide results in decreased expression of ACTR3B mRNA

NCBI chr 4:9,261,631...9,355,496
Ensembl chr 4:9,262,233...9,355,441

G

ALF transcription elongation factor 1

increases expression

cupric oxide results in increased expression of AFF1 mRNA

NCBI chr14:5,861,188...6,024,196
Ensembl chr14:5,863,961...6,024,729

G

adenosylhomocysteinase

decreases expression

cupric oxide results in decreased expression of AHCY protein

NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393

G

AHNAK nucleoprotein

decreases expression
decreases phosphorylation

cupric oxide results in decreased expression of AHNAK protein
cupric oxide results in decreased phosphorylation of AHNAK protein

NCBI chr 1:205,882,225...205,970,934
Ensembl chr 1:205,882,273...205,970,926

G

activator of Hsp90 ATPase activity 1

increases phosphorylation

cupric oxide results in increased phosphorylation of AHSA1 protein

NCBI chr 6:106,913,296...106,921,347
Ensembl chr 6:106,913,530...106,921,345

G

ajuba LIM protein

decreases expression

cupric oxide results in decreased expression of AJUBA mRNA

NCBI chr15:28,019,775...28,031,537
Ensembl chr15:28,019,778...28,030,021

G

AKT1 substrate 1

increases phosphorylation

cupric oxide results in increased phosphorylation of AKT1S1 protein

NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677

G

albumin

multiple interactions
decreases expression

[cupric oxide co-treated with lead oxide co-treated with Zinc Oxide] results in decreased expression of ALB protein
cupric oxide results in decreased expression of ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

decreases expression

cupric oxide results in decreased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldolase, fructose-bisphosphate A

decreases expression

cupric oxide results in decreased expression of ALDOA protein

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

aldolase, fructose-bisphosphate C

decreases expression

cupric oxide results in decreased expression of ALDOC protein

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

ALG14, UDP-N-acetylglucosaminyltransferase subunit

increases phosphorylation

cupric oxide results in increased phosphorylation of ALG14 protein

NCBI chr 2:209,368,285...209,445,425
Ensembl chr 2:209,368,312...209,445,431

G

alpha-kinase 2

decreases expression

cupric oxide results in decreased expression of ALPK2 mRNA

NCBI chr18:58,775,603...58,906,150
Ensembl chr18:58,775,605...58,906,258

G

alsin Rho guanine nucleotide exchange factor ALS2

increases expression

cupric oxide results in increased expression of ALS2 mRNA

NCBI chr 9:60,613,182...60,686,394
Ensembl chr 9:60,613,167...60,670,737

G

angiopoietin-like 4

decreases expression

cupric oxide results in decreased expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

annexin A2

decreases phosphorylation

cupric oxide results in decreased phosphorylation of ANXA2 protein

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

activity-regulated cytoskeleton-associated protein

increases expression

cupric oxide results in increased expression of ARC mRNA

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

amphiregulin

decreases expression

cupric oxide results in decreased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

ARF GTPase 3

decreases expression

cupric oxide results in decreased expression of ARF3 protein

NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002

G

Rho GDP dissociation inhibitor alpha

decreases expression

cupric oxide analog results in decreased expression of ARHGDIA protein

NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023

G

Rho GDP dissociation inhibitor beta

decreases expression

cupric oxide analog results in decreased expression of ARHGDIB protein

NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

cupric oxide results in increased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

activating transcription factor 1

increases expression

cupric oxide results in increased expression of ATF1 mRNA

NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670

G

activating transcription factor 3

increases expression

cupric oxide results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATPase H+ transporting V1 subunit A

increases expression

cupric oxide results in increased expression of ATP6V1A mRNA

NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694

G

ATPase H+ transporting V1 subunit B2

increases expression

cupric oxide results in increased expression of ATP6V1B2 mRNA

NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745

G

ATPase H+ transporting V1 subunit C1

increases expression

cupric oxide results in increased expression of ATP6V1C1 mRNA

NCBI chr 7:69,834,464...69,872,278
Ensembl chr 7:69,834,463...69,872,278

G

ATPase H+ transporting V1 subunit D

increases expression

cupric oxide results in increased expression of ATP6V1D mRNA

NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303

G

ATPase H+ transporting V1 subunit G1

increases expression

cupric oxide results in increased expression of ATP6V1G1 mRNA

NCBI chr 5:76,961,462...76,967,642
Ensembl chr 5:76,961,499...76,969,463

G

ATPase H+ transporting V1 subunit H

increases expression
decreases expression

cupric oxide results in increased expression of ATP6V1H mRNA
cupric oxide analog results in decreased expression of ATP6V1H protein

PMID:22077320 PMID:23882024

NCBI chr 5:14,379,029...14,484,703
Ensembl chr 5:14,378,257...14,537,962

G

ATPase copper transporting alpha

increases expression

cupric oxide analog results in increased expression of ATP7A mRNA; cupric oxide analog results in increased expression of ATP7A protein

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

ATPase copper transporting beta

affects localization
increases expression

cupric oxide affects the localization of ATP7B protein
cupric oxide analog results in increased expression of ATP7B mRNA; cupric oxide analog results in increased expression of ATP7B protein

PMID:24343273 PMID:24815816

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

G

ATR serine/threonine kinase

decreases expression

cupric oxide results in decreased expression of ATR mRNA

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

ATRX, chromatin remodeler

decreases expression

cupric oxide results in decreased expression of ATRX mRNA

NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330

G

aurora kinase A

decreases expression

cupric oxide results in decreased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

aurora kinase B

decreases expression

cupric oxide results in decreased expression of AURKB mRNA

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

axin 2

decreases expression

cupric oxide results in decreased expression of AXIN2 mRNA

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

Axl receptor tyrosine kinase

decreases expression

cupric oxide results in decreased expression of AXL mRNA

NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265

G

barrier to autointegration nuclear assembly factor 1

decreases expression

cupric oxide results in decreased expression of BANF1 protein

NCBI chr 1:202,672,170...202,674,215
Ensembl chr 1:202,671,305...202,674,188

G

BRCA1 associated RING domain 1

decreases expression

cupric oxide results in decreased expression of BARD1 mRNA

NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

trans-sodium crocetinate inhibits the reaction [cupric oxide results in increased expression of BAX mRNA]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

decreases expression

cupric oxide results in decreased expression of BBC3 mRNA

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCAR3 adaptor protein, NSP family member

decreases expression

cupric oxide results in decreased expression of BCAR3 mRNA

NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

trans-sodium crocetinate inhibits the reaction [cupric oxide results in decreased expression of BCL2 mRNA]

PMID:25701151 PMID:32285662

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

decreases expression

cupric oxide results in decreased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 1

decreases expression

cupric oxide results in decreased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

brain expressed X-linked 1

increases expression

cupric oxide results in increased expression of BEX2 mRNA

NCBI chr X:99,219,014...99,220,518
Ensembl chr X:99,219,014...99,220,958

G

biogenesis of lysosomal organelles complex-1, subunit 1

increases expression

cupric oxide results in increased expression of BLOC1S1 mRNA

NCBI chr 7:1,347,495...1,351,103
Ensembl chr 7:1,340,934...1,351,558

G

BCL2 interacting protein 3 like

increases expression

cupric oxide results in increased expression of BNIP3L mRNA

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

G

BRCA2, DNA repair associated

increases expression

cupric oxide results in increased expression of BRCA2 mRNA

NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567

G

BRF2 general transcription factor 3B subunit

increases expression

cupric oxide results in increased expression of BRF2 mRNA

NCBI chr16:64,928,334...64,933,057
Ensembl chr16:64,928,300...64,933,059

G

basigin

decreases expression

cupric oxide results in decreased expression of BSG protein

NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387

G

similar to human chromosome 5 open reading frame 58

increases expression

cupric oxide results in increased expression of C5ORF58 mRNA

NCBI chr10:18,690,958...18,697,224
Ensembl chr10:18,688,847...18,697,220

G

complement C1q binding protein

decreases expression

cupric oxide results in decreased expression of C1QBP protein

NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649

G

complement C1s

increases expression

cupric oxide results in increased expression of C1S mRNA

NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303

G

calmodulin 1

increases expression

cupric oxide results in increased expression of CALM1 protein

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

G

calreticulin

decreases expression

cupric oxide results in decreased expression of CALR protein

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

calumenin

increases expression

cupric oxide results in increased expression of CALU protein

NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593

G

cyclase associated actin cytoskeleton regulatory protein 1

decreases expression

cupric oxide results in decreased expression of CAP1 protein

NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769

G

capping actin protein of muscle Z-line subunit beta

increases expression

cupric oxide results in increased expression of CAPZB protein

NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409

G

caspase recruitment domain family, member 6

increases expression

cupric oxide results in increased expression of CARD6 mRNA

NCBI chr 2:54,194,343...54,206,902
Ensembl chr 2:54,195,739...54,206,846

G

caspase 3

decreases activity

cupric oxide results in decreased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

decreases activity
multiple interactions
decreases expression

cupric oxide results in decreased activity of CAT protein
CAT protein inhibits the reaction [cupric oxide results in increased abundance of Reactive Oxygen Species]
cupric oxide analog results in decreased expression of CAT protein
costus absolute inhibits the reaction [cupric oxide analog results in decreased expression of CAT protein]

PMID:19699289 PMID:20171267 PMID:36286243

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

coiled-coil domain containing 80

decreases expression

cupric oxide results in decreased expression of CCDC80 mRNA

NCBI chr11:55,685,165...55,718,827
Ensembl chr11:55,685,872...55,719,137

G

C-C motif chemokine ligand 2

increases secretion
affects expression

cupric oxide results in increased secretion of CCL2 protein
cupric oxide affects the expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin A2

decreases expression

cupric oxide results in decreased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

decreases expression

cupric oxide results in decreased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

decreases expression

cupric oxide results in decreased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin K

increases expression

cupric oxide results in increased expression of CCNK mRNA

NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191

G

chaperonin containing TCP1 subunit 3

decreases expression

cupric oxide results in decreased expression of CCT3 protein

NCBI chr 2:173,765,701...173,790,353
Ensembl chr 2:173,765,698...173,790,757

G

chaperonin containing TCP1 subunit 5

increases expression

cupric oxide results in increased expression of CCT5 protein

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

chaperonin containing TCP1 subunit 6A

increases expression

cupric oxide results in increased expression of CCT6A protein

NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337

G

chaperonin containing TCP1 subunit 8

increases expression

cupric oxide results in increased expression of CCT8 protein

NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079

G

cell division cycle 20

decreases expression

cupric oxide results in decreased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 40

increases expression

cupric oxide results in increased expression of CDC40 mRNA

NCBI chr20:44,273,080...44,325,605
Ensembl chr20:44,273,089...44,325,358

G

cell division cycle 42

decreases expression

cupric oxide results in decreased expression of CDC42 protein

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

G

cell division cycle associated 3

decreases expression

cupric oxide results in decreased expression of CDCA3 mRNA

NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799

G

cyclin-dependent kinase 1

decreases expression

cupric oxide results in decreased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 5 regulatory subunit 2

increases expression

cupric oxide results in increased expression of CDK5R2 mRNA

NCBI chr 9:76,416,251...76,417,719
Ensembl chr 9:76,416,062...76,418,344

G

cyclin-dependent kinase 6

decreases expression

cupric oxide results in decreased expression of CDK6 mRNA

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase-like 3

increases expression

cupric oxide results in increased expression of CDKL3 mRNA

NCBI chr10:36,263,212...36,349,268
Ensembl chr10:36,266,977...36,349,268

G

cyclin-dependent kinase inhibitor 1A

increases expression

cupric oxide results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

decreases expression

cupric oxide results in decreased expression of CDKN1B mRNA

PMID:22077320 PMID:32285662

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

CDKN2A interacting protein

increases expression

cupric oxide results in increased expression of CDKN2AIP mRNA

NCBI chr16:44,536,147...44,546,216
Ensembl chr16:44,536,234...44,540,033

G

cyclin-dependent kinase inhibitor 2C

decreases expression

cupric oxide results in decreased expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

CCAAT/enhancer binding protein gamma

increases expression

cupric oxide results in increased expression of CEBPG mRNA

NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569

G

CUGBP, Elav-like family member 1

increases expression

cupric oxide results in increased expression of CELF1 mRNA

NCBI chr 3:76,924,591...76,999,429
Ensembl chr 3:76,924,613...76,999,426

G

centromere protein A

decreases expression

cupric oxide results in decreased expression of CENPA mRNA

NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675

G

cofilin 1

increases expression

cupric oxide results in increased expression of CFL1 protein

NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587

G

chromosome alignment maintaining phosphoprotein 1

decreases phosphorylation

cupric oxide results in decreased phosphorylation of CHAMP1 protein

NCBI chr16:75,733,958...75,744,931
Ensembl chr16:75,733,805...75,744,984

G

citron rho-interacting serine/threonine kinase

decreases expression

cupric oxide results in decreased expression of CIT mRNA

NCBI chr12:40,603,073...40,764,846
Ensembl chr12:40,605,563...40,763,860

G

cytoskeleton associated protein 2

decreases expression

cupric oxide results in decreased expression of CKAP2 mRNA

NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913

G

cytoskeleton associated protein 5

decreases expression

cupric oxide results in decreased expression of CKAP5 mRNA

NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264

G

creatine kinase B

multiple interactions

costus absolute inhibits the reaction [cupric oxide analog results in increased secretion of [CKM protein binds to CKB protein]]; cupric oxide analog results in increased secretion of [CKM protein binds to CKB protein]

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

creatine kinase, M-type

multiple interactions

costus absolute inhibits the reaction [cupric oxide analog results in increased secretion of [CKM protein binds to CKB protein]]; cupric oxide analog results in increased secretion of [CKM protein binds to CKB protein]

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

chloride voltage-gated channel 6

increases expression

cupric oxide results in increased expression of CLCN6 mRNA

NCBI chr 5:158,434,299...158,465,174
Ensembl chr 5:158,434,299...158,465,059

G

claudin 23

decreases expression

cupric oxide results in decreased expression of CLDN23 mRNA

NCBI chr16:56,413,677...56,415,401
Ensembl chr16:56,413,381...56,415,523

G

chloride intracellular channel 1

decreases expression

cupric oxide analog results in decreased expression of CLIC1 protein

NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712

G

CDC-like kinase 1

increases expression

cupric oxide results in increased expression of CLK1 mRNA

NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000

G

clusterin

increases expression

cupric oxide results in increased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

calponin 3

increases expression

cupric oxide results in increased expression of CNN3 protein

NCBI chr 2:209,518,948...209,550,107
Ensembl chr 2:209,518,948...209,550,104

G

cochlin

decreases expression

cupric oxide results in decreased expression of COCH mRNA

NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109

G

collagen type IV alpha 1 chain

decreases expression

cupric oxide results in decreased expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

collagen type V alpha 1 chain

decreases expression

cupric oxide results in decreased expression of COL5A1 mRNA

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

G

collagen type V alpha 2 chain

decreases expression

cupric oxide results in decreased expression of COL5A2 mRNA

NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154

G

cytoplasmic polyadenylation element binding protein 4

increases expression

cupric oxide results in increased expression of CPEB4 mRNA

NCBI chr10:15,717,794...15,780,482
Ensembl chr10:15,717,794...15,780,603

G

cAMP responsive element modulator

increases expression

cupric oxide results in increased expression of CREM mRNA

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

CXXC repeat containing interactor of PDZ3 domain

increases expression

cupric oxide results in increased expression of CRIPT mRNA

NCBI chr 6:7,581,428...7,589,384
Ensembl chr 6:7,580,703...7,589,399

G

crystallin, alpha B

increases expression

cupric oxide results in increased expression of CRYAB mRNA

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

crystallin beta-gamma domain containing 1

increases expression

cupric oxide results in increased expression of CRYBG1 protein

NCBI chr20:47,425,030...47,496,918
Ensembl chr20:47,426,183...47,621,392

G

cystatin A

increases expression

cupric oxide results in increased expression of CSTA mRNA

NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488

G

cytochrome b5 reductase 2

increases expression

cupric oxide results in increased expression of CYB5R2 mRNA

NCBI chr 1:161,655,862...161,664,359
Ensembl chr 1:161,655,864...161,664,097

G

death associated protein kinase 1

decreases expression

cupric oxide results in decreased expression of DAPK1 mRNA

NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991

G

DBF4-CDC7 kinase regulatory subunit

decreases expression

cupric oxide results in decreased expression of DBF4 mRNA

NCBI chr 4:25,676,570...25,701,152
Ensembl chr 4:25,676,634...25,701,066

G

DNA-damage inducible transcript 3

increases expression

cupric oxide results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEAD-box helicase 5

increases expression

cupric oxide results in increased expression of DDX5 protein

NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283

G

dehydrogenase/reductase 2

increases expression

cupric oxide results in increased expression of DHRS2 mRNA

NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644

G

DEXH-box helicase 58

increases expression

cupric oxide results in increased expression of DHX58 mRNA

NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525

G

DIS3-like exosome 3'-5' exoribonuclease

decreases expression

cupric oxide results in decreased expression of DIS3L mRNA

NCBI chr 8:64,803,925...64,840,306
Ensembl chr 8:64,803,927...64,840,165

G

DLC1 Rho GTPase activating protein

decreases expression

cupric oxide results in decreased expression of DLC1 mRNA

NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439

G

discs large MAGUK scaffold protein 5

decreases expression

cupric oxide results in decreased expression of DLG5 mRNA

NCBI chr15:75,786...209,735
Ensembl chr15:75,786...187,837

G

DLG associated protein 5

decreases expression

cupric oxide results in decreased expression of DLGAP5 mRNA

NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518

G

DnaJ heat shock protein family (Hsp40) member A1

increases expression

cupric oxide results in increased expression of DNAJA1 mRNA

NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967

G

DnaJ heat shock protein family (Hsp40) member A4

increases expression

cupric oxide results in increased expression of DNAJA4 mRNA

NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207

G

DnaJ heat shock protein family (Hsp40) member B1

increases expression

cupric oxide results in increased expression of DNAJB1 mRNA

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member B6

increases expression

cupric oxide results in increased expression of DNAJB6 mRNA

NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

cupric oxide results in increased expression of DNAJB9 mRNA

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

DnaJ heat shock protein family (Hsp40) member C3

increases expression

cupric oxide results in increased expression of DNAJC3 mRNA

NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181

G

DnaJ heat shock protein family (Hsp40) member C5

decreases expression

cupric oxide results in decreased expression of DNAJC5 mRNA

NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935

G

dystonin

decreases expression

cupric oxide results in decreased expression of DST mRNA

NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615

G

E2F transcription factor 1

increases expression

cupric oxide results in increased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 6

increases expression

cupric oxide results in increased expression of E2F6 mRNA

NCBI chr 6:39,592,224...39,608,685
Ensembl chr 6:39,592,228...39,608,683

G

E2F transcription factor 7

decreases expression

cupric oxide results in decreased expression of E2F7 mRNA

NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734

G

E2F transcription factor 8

decreases expression

cupric oxide results in decreased expression of E2F8 mRNA

NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098

G

enoyl-CoA hydratase, short chain 1

decreases expression

cupric oxide results in decreased expression of ECHS1 protein

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

eukaryotic translation elongation factor 1 beta 2

decreases expression
increases expression

cupric oxide analog results in decreased expression of EEF1B2 protein
cupric oxide results in increased expression of EEF1B2 protein

PMID:23882024 PMID:25470785

NCBI chr 9:64,580,163...64,582,737
Ensembl chr 9:64,579,893...64,582,737

G

eukaryotic translation elongation factor 1 delta

decreases expression

cupric oxide analog results in decreased expression of EEF1D protein

NCBI chr 7:107,581,930...107,596,735
Ensembl chr 7:107,581,930...107,608,799

G

EGF containing fibulin extracellular matrix protein 1

decreases expression

cupric oxide results in decreased expression of EFEMP1 mRNA

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018

G

EF hand domain family, member B

decreases expression

cupric oxide results in decreased expression of EFHB mRNA

NCBI chr 9:6,372,191...6,441,678
Ensembl chr 9:6,372,194...6,441,919

G

early growth response 1

increases expression

cupric oxide results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

euchromatic histone lysine methyltransferase 1

decreases expression

cupric oxide results in decreased expression of EHMT1 mRNA

NCBI chr 3:7,580,680...7,729,046
Ensembl chr 3:7,580,683...7,729,007

G

eukaryotic translation initiation factor 2 alpha kinase 4

decreases expression

cupric oxide results in decreased expression of EIF2AK4 mRNA

NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630

G

eukaryotic translation initiation factor 3, subunit B

decreases phosphorylation

cupric oxide results in decreased phosphorylation of EIF3B protein

NCBI chr12:14,196,403...14,220,865
Ensembl chr12:14,196,403...14,220,886

G

eukaryotic translation initiation factor 3, subunit F

decreases expression

cupric oxide results in decreased expression of EIF3F protein

NCBI chr 1:162,934,220...162,943,204
Ensembl chr 1:162,934,212...162,943,204

G

eukaryotic translation initiation factor 3, subunit G

affects phosphorylation

cupric oxide affects the phosphorylation of EIF3G protein

NCBI chr 8:19,429,728...19,433,760
Ensembl chr 8:19,429,643...19,433,808

G

eukaryotic translation initiation factor 3, subunit L

increases expression

cupric oxide results in increased expression of EIF3L protein

NCBI chr 7:110,652,565...110,663,614
Ensembl chr 7:110,627,107...110,663,614

G

eukaryotic translation initiation factor 4H

increases expression

cupric oxide results in increased expression of EIF4H protein

NCBI chr12:22,083,155...22,099,876
Ensembl chr12:22,082,835...22,099,876

G

eukaryotic translation initiation factor 5A

decreases expression

cupric oxide analog results in decreased expression of EIF5A protein

NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656

G

eukaryotic translation initiation factor 5B

decreases phosphorylation

cupric oxide results in decreased phosphorylation of EIF5B protein

NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482

G

elongation factor for RNA polymerase II

increases expression

cupric oxide results in increased expression of ELL mRNA

NCBI chr16:18,843,775...18,891,484
Ensembl chr16:18,843,780...18,891,118

G

Eph receptor B2

decreases expression

cupric oxide results in decreased expression of EPHB2 mRNA

NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059

G

epoxide hydrolase 1

decreases expression

cupric oxide results in decreased expression of EPHX1 mRNA

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

erb-b2 receptor tyrosine kinase 2

decreases expression

cupric oxide results in decreased expression of ERBB2 mRNA

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

endoplasmic reticulum protein 29

increases expression

cupric oxide analog results in increased expression of ERP29 protein

NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376

G

esterase D

increases expression

cupric oxide analog results in increased expression of ESD protein

NCBI chr15:50,043,634...50,063,134
Ensembl chr15:50,043,632...50,063,144

G

ecotropic viral integration site 5

decreases expression

cupric oxide results in decreased expression of EVI5 mRNA

NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678

G

ezrin

decreases expression

cupric oxide results in decreased expression of EZR protein

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

family with sequence similarity 241 member B

increases expression

cupric oxide results in increased expression of FAM241B mRNA

NCBI chr20:30,052,315...30,055,247
Ensembl chr20:30,052,324...30,055,084

G

family with sequence similarity 83, member D

decreases expression

cupric oxide results in decreased expression of FAM83D mRNA

NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192

G

F-box and leucine-rich repeat protein 19

increases expression

cupric oxide results in increased expression of FBXL19 mRNA

NCBI chr 1:182,356,899...182,380,839
Ensembl chr 1:182,360,830...182,380,083

G

F-box and leucine-rich repeat protein 4

decreases expression

cupric oxide results in decreased expression of FBXL4 mRNA

NCBI chr 5:35,955,801...36,029,446
Ensembl chr 5:35,955,812...36,029,443

G

F-box protein 5

decreases expression

cupric oxide results in decreased expression of FBXO5 mRNA

NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437

G

farnesyl diphosphate synthase

decreases expression

cupric oxide analog results in decreased expression of FDPS protein

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

FKBP prolyl isomerase 7

decreases expression

cupric oxide results in decreased expression of FKBP7 mRNA

NCBI chr 3:61,609,384...61,623,710
Ensembl chr 3:61,608,557...61,623,280

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

cupric oxide results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

cupric oxide results in increased expression of FOSB mRNA

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

forkhead box F2

decreases expression

cupric oxide results in decreased expression of FOXF2 mRNA

NCBI chr17:32,835,730...32,842,547
Ensembl chr17:32,836,777...32,842,176

G

forkhead box N3

increases expression

cupric oxide results in increased expression of FOXN3 mRNA

NCBI chr 6:118,462,018...118,842,442
Ensembl chr 6:118,466,025...118,842,401

G

fibronectin type III and SPRY domain containing 1-like

increases expression

cupric oxide results in increased expression of FSD1L mRNA

NCBI chr 5:68,258,877...68,334,931
Ensembl chr 5:68,258,932...68,334,928

G

follicle stimulating hormone subunit beta

increases expression

cupric oxide results in increased expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

G0/G1switch 2

decreases expression

cupric oxide results in decreased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

GABA type A receptor associated protein like 1

increases expression

cupric oxide results in increased expression of GABARAPL1 mRNA

NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450

G

GA binding protein transcription factor subunit alpha

increases expression

cupric oxide results in increased expression of GABPA mRNA

NCBI chr11:23,888,586...23,917,612
Ensembl chr11:23,888,815...23,917,605

G

growth arrest and DNA-damage-inducible, alpha

increases expression

cupric oxide results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

growth arrest and DNA-damage-inducible, beta

increases expression
decreases response to substance

cupric oxide results in increased expression of GADD45B mRNA; cupric oxide results in increased expression of GADD45B protein
GADD45B protein results in decreased susceptibility to cupric oxide

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

growth arrest and DNA-damage-inducible, gamma

increases expression

cupric oxide results in increased expression of GADD45G mRNA; cupric oxide results in increased expression of GADD45G protein

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

G

galactokinase 1

decreases expression

cupric oxide analog results in decreased expression of GALK1 protein

NCBI chr10:101,243,146...101,247,323
Ensembl chr10:101,235,994...101,247,337

G

golgi brefeldin A resistant guanine nucleotide exchange factor 1

increases phosphorylation

cupric oxide results in increased phosphorylation of GBF1 protein

NCBI chr 1:245,018,535...245,147,052
Ensembl chr 1:245,018,568...245,147,042

G

glutamate cysteine ligase, modifier subunit

increases expression

cupric oxide analog results in increased expression of GCLM protein
cupric oxide results in increased expression of GCLM mRNA

PMID:23882024 PMID:24343273

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

growth differentiation factor 15

increases expression

cupric oxide results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

GTP binding protein overexpressed in skeletal muscle

increases expression

cupric oxide results in increased expression of GEM mRNA

NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222

G

gem (nuclear organelle) associated protein 5

decreases expression

cupric oxide results in decreased expression of GEMIN5 mRNA

NCBI chr10:42,295,729...42,342,902
Ensembl chr10:42,297,515...42,342,892

G

gamma-glutamyltransferase 1

multiple interactions

[cupric oxide co-treated with lead oxide co-treated with Zinc Oxide] results in increased activity of GGT1 protein; [cupric oxide co-treated with lead oxide] results in increased activity of GGT1 protein

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

glyoxalase 1

decreases expression

cupric oxide results in decreased expression of GLO1 protein

NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649

G

glutamate dehydrogenase 1

increases expression

cupric oxide analog results in increased expression of GLUD1 protein

NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957

G

G protein subunit alpha i2

decreases expression

cupric oxide analog results in decreased expression of GNAI2 protein

NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979

G

G-protein signaling modulator 2

decreases expression

cupric oxide results in decreased expression of GPSM2 mRNA

NCBI chr 2:196,327,149...196,375,322
Ensembl chr 2:196,327,149...196,375,154

G

glutathione peroxidase 1

multiple interactions
decreases expression

trans-sodium crocetinate inhibits the reaction [cupric oxide results in decreased expression of GPX1 mRNA]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

decreases expression

cupric oxide results in decreased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 4

decreases expression
multiple interactions

cupric oxide results in decreased expression of GPX4 mRNA
trans-sodium crocetinate inhibits the reaction [cupric oxide results in decreased expression of GPX4 mRNA]

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

granulin precursor

increases expression

cupric oxide results in increased expression of GRN mRNA

NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775

G

glutathione-disulfide reductase

decreases activity

cupric oxide results in decreased activity of GSR protein

PMID:19699289 PMID:20600438

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

general transcription factor IIB

increases expression

cupric oxide results in increased expression of GTF2B mRNA

NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651

G

G-2 and S-phase expressed 1

decreases expression

cupric oxide results in decreased expression of GTSE1 mRNA

NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806

G

H1.10 linker histone

decreases expression

cupric oxide results in decreased expression of H1-10 mRNA

NCBI chr 4:120,440,515...120,441,578
Ensembl chr 4:120,440,870...120,441,448

G

H2A clustered histone 21

increases expression

cupric oxide results in increased expression of H2AC21 mRNA

NCBI chr 2:183,779,355...183,779,788

G

H2A.X variant histone

increases expression
decreases expression

cupric oxide analog results in increased expression of H2AX protein
cupric oxide results in decreased expression of H2AX mRNA

PMID:22077320 PMID:27270449

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

HMG-box transcription factor 1

increases expression

cupric oxide results in increased expression of HBP1 mRNA

NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787

G

histone deacetylase 1

decreases phosphorylation

cupric oxide results in decreased phosphorylation of HDAC1 protein

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

heparin binding growth factor

increases expression

cupric oxide results in increased expression of HDGF protein

NCBI chr 2:173,370,147...173,379,756
Ensembl chr 2:173,370,465...173,379,747

G

hes family bHLH transcription factor 1

increases expression

cupric oxide results in increased expression of HES1 mRNA

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hes-related family bHLH transcription factor with YRPW motif 1

increases expression

cupric oxide results in increased expression of HEY1 mRNA

NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312

G

histidine triad nucleotide binding protein 3

increases expression

cupric oxide results in increased expression of HINT3 mRNA

NCBI chr 1:27,035,936...27,045,799
Ensembl chr 1:27,035,905...27,047,721

G

high mobility group box 2

decreases expression

cupric oxide results in decreased expression of HMGB2 mRNA

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140

G

heme oxygenase 1

multiple interactions
increases expression

[Buthionine Sulfoximine co-treated with Dehydroascorbic Acid] promotes the reaction [cupric oxide results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [cupric oxide results in increased expression of HMOX1 mRNA]; Dehydroascorbic Acid promotes the reaction [cupric oxide results in increased expression of HMOX1 mRNA]
cupric oxide results in increased expression of HMOX1 mRNA; cupric oxide results in increased expression of HMOX1 protein
cupric oxide analog results in increased expression of HMOX1 protein

PMID:19683516 PMID:23882024 PMID:24343273 PMID:32285662 PMID:33839236

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein H2

increases expression

cupric oxide results in increased expression of HNRNPH2 mRNA

NCBI chr X:97,780,890...97,786,846
Ensembl chr X:97,780,785...97,787,041

G

heterogeneous nuclear ribonucleoprotein K

increases phosphorylation

cupric oxide results in increased phosphorylation of HNRNPK protein

NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997

G

heterogeneous nuclear ribonucleoprotein L

decreases expression

cupric oxide results in decreased expression of HNRNPL protein

NCBI chr 1:84,098,558...84,111,568
Ensembl chr 1:84,100,879...84,111,553

G

histamine receptor H 1

increases expression

cupric oxide results in increased expression of HRH1 mRNA

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

heat shock transcription factor 2

increases expression

cupric oxide results in increased expression of HSF2 mRNA

NCBI chr20:36,819,864...36,847,490
Ensembl chr20:36,819,864...36,850,174

G

heat shock protein 90 alpha family class A member 1

increases expression

cupric oxide results in increased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein family A (Hsp70) member 13

increases expression

cupric oxide results in increased expression of HSPA13 mRNA

NCBI chr11:14,375,669...14,389,853
Ensembl chr11:14,373,275...14,389,895

G

heat shock protein family A (Hsp70) member 1A

increases expression

cupric oxide results in increased expression of HSPA1A mRNA; cupric oxide results in increased expression of HSPA1A protein

PMID:25470785 PMID:32285662

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression

cupric oxide results in increased expression of HSPA6 mRNA

PMID:22077320 PMID:24343273

NCBI chr13:83,273,176...83,274,317

G

heat shock protein family A (Hsp70) member 8

increases expression

cupric oxide results in increased expression of HSPA8 protein

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family A (Hsp70) member 9

decreases expression

cupric oxide results in decreased expression of HSPA9 protein

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

heat shock protein family B (small) member 1

increases phosphorylation

cupric oxide results in increased phosphorylation of HSPB1 protein

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family B (small) member 8

increases expression

cupric oxide results in increased expression of HSPB8 mRNA

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

G

heat shock protein family E (Hsp10) member 1

decreases expression

cupric oxide results in decreased expression of HSPE1 protein

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

heat shock protein family H (Hsp110) member 1

increases expression

cupric oxide results in increased expression of HSPH1 mRNA

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

HtrA serine peptidase 3

increases expression

cupric oxide results in increased expression of HTRA3 mRNA

NCBI chr14:75,068,917...75,097,315
Ensembl chr14:75,068,917...75,097,315

G

HUS1 checkpoint clamp component

increases expression

cupric oxide results in increased expression of HUS1 mRNA

NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442

G

HYLS1, centriolar and ciliogenesis associated

decreases expression

cupric oxide results in decreased expression of HYLS1 mRNA

NCBI chr 8:33,912,692...33,921,760
Ensembl chr 8:33,912,692...33,921,760

G

insulin-like growth factor 2

increases expression

cupric oxide results in increased expression of IGF2 mRNA

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

insulin-like growth factor binding protein 3

decreases expression

cupric oxide results in decreased expression of IGFBP3 mRNA

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

interleukin 1 alpha

multiple interactions

cupric oxide results in increased expression of and results in increased secretion of IL1A protein

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 6

multiple interactions
increases secretion
affects expression

cupric oxide results in increased expression of and results in increased secretion of IL6 protein
cupric oxide results in increased secretion of IL6 protein
cupric oxide affects the expression of IL6 mRNA

PMID:22954531 PMID:28705761

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin enhancer binding factor 3

decreases phosphorylation

cupric oxide results in decreased phosphorylation of ILF3 protein

NCBI chr 8:19,922,409...19,960,495
Ensembl chr 8:19,922,460...19,960,350

G

inositol monophosphatase 1

decreases expression

cupric oxide analog results in decreased expression of IMPA1 protein

NCBI chr 2:91,462,781...91,484,057
Ensembl chr 2:91,462,799...91,484,313

G

inhibitor of growth family, member 4

increases expression

cupric oxide results in increased expression of ING4 mRNA

NCBI chr 4:157,841,882...157,850,519
Ensembl chr 4:157,841,951...157,850,265

G

insulin induced gene 1

increases expression

cupric oxide results in increased expression of INSIG1 mRNA

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

intracisternal A particle-promoted polypeptide

decreases expression

cupric oxide results in decreased expression of IPP mRNA

NCBI chr 5:129,962,528...130,001,237
Ensembl chr 5:129,962,643...130,001,242

G

IQ motif containing GTPase activating protein 1

increases expression

cupric oxide results in increased expression of IQGAP1 protein

NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755

G

insulin receptor substrate 1

decreases expression

cupric oxide results in decreased expression of IRS1 mRNA

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

interferon stimulated exonuclease gene 20

increases expression

cupric oxide results in increased expression of ISG20 mRNA

NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027

G

ISY1 splicing factor homolog

increases expression

cupric oxide results in increased expression of ISY1 mRNA

NCBI chr 4:120,276,535...120,297,227
Ensembl chr 4:120,276,292...120,297,188

G

Jun dimerization protein 2

increases expression

cupric oxide results in increased expression of JDP2 mRNA

NCBI chr 6:105,261,619...105,302,386
Ensembl chr 6:105,261,373...105,301,485

G

Jupiter microtubule associated homolog 1

decreases expression

cupric oxide results in decreased expression of JPT1 mRNA

NCBI chr10:100,744,468...100,762,504
Ensembl chr10:100,686,797...100,784,513

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

cupric oxide results in increased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kelch repeat and BTB domain containing 4

increases expression

cupric oxide results in increased expression of KBTBD4 mRNA

NCBI chr 3:76,883,671...76,889,769
Ensembl chr 3:76,883,014...76,890,799

G

kelch repeat and BTB domain containing 8

increases expression

cupric oxide results in increased expression of KBTBD8 mRNA

NCBI chr 4:127,675,967...127,688,785
Ensembl chr 4:127,676,141...127,687,697

G

Kelch-like ECH-associated protein 1

decreases expression

cupric oxide results in decreased expression of KEAP1 mRNA

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

kinesin family member 18A

decreases expression

cupric oxide results in decreased expression of KIF18A mRNA

NCBI chr 3:95,764,388...95,824,756
Ensembl chr 3:95,764,388...95,824,582

G

kinesin family member 18B

decreases expression

cupric oxide results in decreased expression of KIF18B mRNA

NCBI chr10:87,870,424...87,889,895
Ensembl chr10:87,870,428...87,889,850

G

kinesin family member 20A

decreases expression

cupric oxide results in decreased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

kinesin family member 20B

decreases expression

cupric oxide results in decreased expression of KIF20B mRNA

NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787

G

kinesin family member 23

decreases expression

cupric oxide results in decreased expression of KIF23 mRNA

NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072

G

kinesin family member C1

decreases expression

cupric oxide results in decreased expression of KIFC1 mRNA

NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105

G

KLF transcription factor 7

increases expression

cupric oxide results in increased expression of KLF7 mRNA

NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261

G

kelch-like family member 18

increases expression

cupric oxide results in increased expression of KLHL18 mRNA

NCBI chr 8:110,400,679...110,459,442
Ensembl chr 8:110,400,681...110,459,323

G

kelch-like family, member 42

decreases expression

cupric oxide results in decreased expression of KLHL42 mRNA

NCBI chr 4:179,999,655...180,027,283
Ensembl chr 4:180,004,580...180,027,283

G

kinetochore-localized astrin/SPAG5 binding protein

decreases expression

cupric oxide results in decreased expression of KNSTRN mRNA

NCBI chr 3:105,800,762...105,820,555
Ensembl chr 3:105,800,954...105,820,715

G

La ribonucleoprotein 4

increases expression

cupric oxide results in increased expression of LARP4 mRNA

NCBI chr 7:131,104,470...131,152,692
Ensembl chr 7:131,101,564...131,150,811

G

linker for activation of T cells

increases expression

cupric oxide results in increased expression of LAT mRNA

NCBI chr 1:180,936,536...180,941,561
Ensembl chr 1:180,936,534...180,941,578

G

large tumor suppressor kinase 2

increases expression

cupric oxide results in increased expression of LATS2 mRNA

NCBI chr15:31,825,068...31,877,193
Ensembl chr15:31,825,092...31,877,220

G

galectin 1

increases expression

cupric oxide results in increased expression of LGALS1 protein

NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345

G

DNA ligase 1

increases expression

cupric oxide results in increased expression of LIG1 mRNA

NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413

G

LIM domain and actin binding 1

decreases phosphorylation

cupric oxide results in decreased phosphorylation of LIMA1 protein

NCBI chr 7:130,901,717...131,001,512
Ensembl chr 7:130,901,717...131,001,473

G

LIM domain kinase 2

decreases expression

cupric oxide results in decreased expression of LIMK2 mRNA

NCBI chr14:78,208,182...78,286,106
Ensembl chr14:78,218,063...78,286,007

G

lamin B1

decreases expression

cupric oxide results in decreased expression of LMNB1 mRNA; cupric oxide results in decreased expression of LMNB1 protein

PMID:22077320 PMID:25470785

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

lamin B2

decreases expression

cupric oxide results in decreased expression of LMNB2 mRNA

NCBI chr 7:8,792,628...8,808,665
Ensembl chr 7:8,789,314...8,808,665

G

leucine rich repeat containing 59

increases expression

cupric oxide results in increased expression of LRRC59 protein

NCBI chr10:79,572,295...79,586,953
Ensembl chr10:79,572,317...79,602,533

G

MAF bZIP transcription factor F

increases expression

cupric oxide results in increased expression of MAFF mRNA

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

MAF bZIP transcription factor G

increases expression

cupric oxide results in increased expression of MAFG mRNA

NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026

G

MAF bZIP transcription factor K

increases expression

cupric oxide results in increased expression of MAFK mRNA

NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048
Ensembl chr12:14,833,984...14,837,048

G

mago homolog, exon junction complex subunit

increases expression

cupric oxide results in increased expression of MAGOH mRNA

NCBI chr 5:122,639,268...122,646,650
Ensembl chr 5:122,639,308...122,646,617

G

microtubule-associated protein 1B

affects phosphorylation

cupric oxide affects the phosphorylation of MAP1B protein

NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317

G

mitogen-activated protein kinase kinase kinase 21

decreases expression

cupric oxide results in decreased expression of MAP3K21 mRNA

NCBI chr19:53,880,032...53,913,560
Ensembl chr19:53,880,238...53,913,576

G

microtubule-associated protein 4

increases phosphorylation

cupric oxide results in increased phosphorylation of MAP4 protein

NCBI chr 8:109,925,233...110,064,370
Ensembl chr 8:109,925,575...110,064,362

G

mitogen activated protein kinase 1

increases activity

cupric oxide analog results in increased activity of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases activity

cupric oxide analog results in increased activity of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

meiosis regulator and mRNA stability factor 1

increases expression

cupric oxide results in increased expression of MARF1 mRNA

NCBI chr10:888,053...932,760
Ensembl chr10:888,076...932,753

G

myoglobin

multiple interactions
increases secretion

costus absolute inhibits the reaction [cupric oxide analog results in increased secretion of MB protein]

NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383

G

minichromosome maintenance complex component 2

decreases phosphorylation

cupric oxide results in decreased phosphorylation of MCM2 protein

NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847

G

minichromosome maintenance complex component 4

decreases expression

cupric oxide results in decreased expression of MCM4 mRNA

NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144

G

minichromosome maintenance complex component 6

decreases expression

cupric oxide results in decreased expression of MCM6 mRNA

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

G

malate dehydrogenase 1

decreases expression

cupric oxide analog results in decreased expression of MDH1 protein

NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925

G

mediator complex subunit 13

increases expression

cupric oxide results in increased expression of MED13 mRNA

NCBI chr10:71,086,978...71,176,535
Ensembl chr10:71,090,516...71,177,242

G

mediator complex subunit 21

increases expression

cupric oxide results in increased expression of MED21 mRNA

NCBI chr 4:179,560,509...179,583,811
Ensembl chr 4:179,560,579...179,567,548

G

maternal embryonic leucine zipper kinase

decreases expression

cupric oxide results in decreased expression of MELK mRNA

NCBI chr 5:58,540,393...58,600,562
Ensembl chr 5:58,540,449...58,600,937

G

methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit

increases expression

cupric oxide results in increased expression of METTL14 mRNA

NCBI chr 2:211,530,598...211,546,845
Ensembl chr 2:211,530,602...211,546,821

G

MLX interacting protein-like

increases expression

cupric oxide results in increased expression of MLXIPL mRNA

NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112

G

matrix metallopeptidase 15

increases expression

cupric oxide results in increased expression of MMP15 protein

NCBI chr19:9,663,449...9,684,943
Ensembl chr19:9,663,449...9,684,943

G

MOB kinase activator 3B

decreases expression

cupric oxide results in decreased expression of MOB3B mRNA

NCBI chr 5:49,546,254...49,737,934
Ensembl chr 5:49,545,815...49,737,934

G

musashi RNA-binding protein 2

increases expression

cupric oxide results in increased expression of MSI2 mRNA

NCBI chr10:73,143,760...73,510,566
Ensembl chr10:73,147,380...73,510,157

G

moesin

increases expression

cupric oxide results in increased expression of MSN protein

NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628

G

metallothionein 1

increases expression

cupric oxide analog results in increased expression of MT1A mRNA; cupric oxide results in increased expression of MT1A mRNA

PMID:22077320 PMID:24815816 PMID:33839236

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

G

metallothionein 1, pseudogene 3

increases expression

cupric oxide results in increased expression of MT1E mRNA

NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135

G

metallothionein 2A

increases expression

cupric oxide results in increased expression of MT2A mRNA

PMID:22077320 PMID:32285662 PMID:33839236

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

metal-regulatory transcription factor 1

increases expression

cupric oxide results in increased expression of MTF1 mRNA

NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136

G

Mtr4 exosome RNA helicase

decreases expression

cupric oxide results in decreased expression of MTREX protein

NCBI chr 2:44,500,326...44,560,624
Ensembl chr 2:44,461,444...44,560,627

G

Metaxin 1

increases expression

cupric oxide results in increased expression of MTX1 mRNA

NCBI chr 2:174,615,460...174,621,383
Ensembl chr 2:174,615,461...174,620,982

G

mucin 2, oligomeric mucus/gel-forming

increases expression

cupric oxide results in increased expression of MUC2 mRNA

NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756

G

mevalonate diphosphate decarboxylase

increases expression

cupric oxide results in increased expression of MVD mRNA

NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971

G

MAX interactor 1, dimerization protein

increases expression

cupric oxide results in increased expression of MXI1 mRNA

NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681

G

MYB binding protein 1a

decreases expression

cupric oxide results in decreased expression of MYBBP1A mRNA

NCBI chr10:57,056,897...57,067,258
Ensembl chr10:57,056,874...57,067,255

G

MYB proto-oncogene like 1

decreases expression

cupric oxide results in decreased expression of MYBL1 mRNA

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

cupric oxide results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin, heavy chain 9

decreases expression

cupric oxide results in decreased expression of MYH9 mRNA

NCBI chr 7:109,343,718...109,424,457
Ensembl chr 7:109,343,706...109,424,457

G

myoneurin

increases expression

cupric oxide results in increased expression of MYNN mRNA

NCBI chr 2:112,779,654...112,797,188
Ensembl chr 2:112,779,657...112,796,397

G

myosin Ib

decreases expression

cupric oxide results in decreased expression of MYO1B mRNA

NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798

G

myosin VC

decreases expression

cupric oxide results in decreased expression of MYO5C mRNA

NCBI chr 8:75,989,497...76,066,485
Ensembl chr 8:75,989,528...76,066,483

G

nascent polypeptide associated complex subunit alpha

increases expression

cupric oxide results in increased expression of NACA protein

NCBI chr 7:468,862...481,992
Ensembl chr 7:469,723...481,992

G

nucleosome assembly protein 1-like 4

increases phosphorylation

cupric oxide results in increased phosphorylation of NAP1L4 protein

NCBI chr 1:198,709,697...198,746,093
Ensembl chr 1:198,709,701...198,746,020

G

nucleosome assembly protein 1-like 5

increases expression

cupric oxide results in increased expression of NAP1L5 mRNA

NCBI chr 4:88,022,670...88,024,988
Ensembl chr 4:88,022,569...88,024,654

G

N-acetyltransferase 1

increases expression

cupric oxide results in increased expression of NAT1 mRNA

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

non-SMC condensin I complex, subunit D2

decreases expression

cupric oxide results in decreased expression of NCAPD2 mRNA

NCBI chr 4:157,968,814...157,992,314
Ensembl chr 4:157,968,815...157,992,020

G

nucleolin

increases expression

cupric oxide results in increased expression of NCL protein

NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136

G

NDC80 kinetochore complex component

decreases expression

cupric oxide results in decreased expression of NDC80 mRNA

NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924

G

NADH:ubiquinone oxidoreductase core subunit S8

increases expression

cupric oxide analog results in increased expression of NDUFS8 protein

NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511

G

nuclear factor of activated T-cells 1

increases expression

cupric oxide results in increased expression of NFATC1 mRNA

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

NFE2 like bZIP transcription factor 3

decreases expression

cupric oxide results in decreased expression of NFE2L3 mRNA

NCBI chr 4:80,506,756...80,534,629
Ensembl chr 4:80,506,756...80,534,629

G

nuclear factor, interleukin 3 regulated

increases expression

cupric oxide results in increased expression of NFIL3 mRNA

NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858

G

nuclear factor kappa B subunit 2

increases expression

cupric oxide results in increased expression of NFKB2 mRNA

NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213

G

nemo like kinase

increases expression

cupric oxide results in increased expression of NLK mRNA

NCBI chr10:63,467,388...63,590,960
Ensembl chr10:63,438,222...63,589,730

G

non-POU domain containing, octamer-binding

decreases expression

cupric oxide results in decreased expression of NONO protein

NCBI chr X:66,554,131...66,571,992
Ensembl chr X:66,554,098...66,571,952

G

nucleophosmin 1

increases phosphorylation

cupric oxide results in increased phosphorylation of NPM1 protein

NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645

G

NAD(P)H quinone dehydrogenase 1

decreases expression

cupric oxide results in decreased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 2, group F, member 2

decreases expression

cupric oxide results in decreased expression of NR2F2 mRNA

NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031

G

nuclear receptor subfamily 4, group A, member 1

increases expression
decreases response to substance

cupric oxide results in increased expression of NR4A1 mRNA; cupric oxide results in increased expression of NR4A1 protein
NR4A1 protein results in decreased susceptibility to cupric oxide

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 4, group A, member 3

increases expression

cupric oxide results in increased expression of NR4A3 mRNA; cupric oxide results in increased expression of NR4A3 protein

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

nuclear casein kinase and cyclin-dependent kinase substrate 1

decreases phosphorylation

cupric oxide results in decreased phosphorylation of NUCKS1 protein

NCBI chr13:43,345,091...43,374,316
Ensembl chr13:43,345,115...43,370,229

G

NUF2 component of NDC80 kinetochore complex

decreases expression

cupric oxide results in decreased expression of NUF2 mRNA

NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766

G

nuclear protein 1, transcriptional regulator

increases expression

cupric oxide results in increased expression of NUPR1 mRNA

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

obscurin like cytoskeletal adaptor 1

decreases expression

cupric oxide results in decreased expression of OBSL1 mRNA

NCBI chr 9:76,967,802...76,993,771
Ensembl chr 9:76,974,253...76,993,560

G

O-linked N-acetylglucosamine (GlcNAc) transferase

increases expression

cupric oxide results in increased expression of OGT mRNA

NCBI chr X:66,771,278...66,816,148
Ensembl chr X:66,771,349...66,816,146

G

olfactomedin-like 2A

decreases expression

cupric oxide results in decreased expression of OLFML2A mRNA

NCBI chr 3:22,688,590...22,717,917
Ensembl chr 3:22,688,598...22,717,909

G

olfactory receptor family 5 subfamily AR member 1

decreases phosphorylation

cupric oxide results in decreased phosphorylation of OR5AR1 protein

NCBI chr 3:70,907,592...70,908,524
Ensembl chr 3:70,906,547...70,912,666

G

olfactory receptor family 5 subfamily L member 14B

increases expression

cupric oxide results in increased expression of OR5L2 mRNA

NCBI chr 3:73,432,677...73,433,615
Ensembl chr 3:73,432,677...73,433,615

G

OTU deubiquitinase, ubiquitin aldehyde binding 1

decreases expression

cupric oxide analog results in decreased expression of OTUB1 protein

NCBI chr 1:204,387,215...204,395,495
Ensembl chr 1:204,387,215...204,395,483

G

OTU deubiquitinase 4

decreases expression

cupric oxide results in decreased expression of OTUD4 mRNA

NCBI chr19:28,236,713...28,279,815
Ensembl chr19:28,236,713...28,279,815

G

prolyl 4-hydroxylase subunit beta

decreases expression

cupric oxide results in decreased expression of P4HB protein

NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500

G

poly(A) binding protein, cytoplasmic 6

decreases expression

cupric oxide results in decreased expression of PABPC3 mRNA

NCBI chr 1:51,045,264...51,048,340
Ensembl chr 1:51,045,233...51,048,340

G

poly(A) binding protein interacting protein 2

increases expression

cupric oxide results in increased expression of PAIP2 mRNA

NCBI chr18:27,199,762...27,218,359
Ensembl chr18:27,199,796...27,214,863

G

phosphatase domain containing, paladin 1

decreases expression

cupric oxide results in decreased expression of PALD1 mRNA

NCBI chr20:29,269,814...29,334,850
Ensembl chr20:29,270,193...29,334,858

G

poly (A) polymerase alpha

increases expression

cupric oxide results in increased expression of PAPOLA mRNA

NCBI chr 6:124,682,015...124,734,706
Ensembl chr 6:124,682,105...124,734,468

G

poly (ADP-ribose) polymerase family, member 4

decreases expression

cupric oxide results in decreased expression of PARP4 mRNA

NCBI chr15:30,690,503...30,792,868
Ensembl chr15:30,686,613...30,828,810

G

poly(rC) binding protein 1

increases expression

cupric oxide results in increased expression of PCBP1 protein

NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500

G

protocadherin 9

decreases expression

cupric oxide results in decreased expression of PCDH9 mRNA

NCBI chr15:69,340,108...70,237,531
Ensembl chr15:69,340,645...70,237,538

G

PCF11 cleavage and polyadenylation factor subunit

increases expression

cupric oxide results in increased expression of PCF11 mRNA

NCBI chr 1:146,694,045...146,724,030
Ensembl chr 1:146,697,646...146,724,124

G

proliferating cell nuclear antigen

decreases expression
increases expression
multiple interactions

cupric oxide results in decreased expression of PCNA mRNA
cupric oxide analog results in decreased expression of PCNA protein
cupric oxide analog results in increased expression of PCNA protein
costus absolute inhibits the reaction [cupric oxide analog results in increased expression of PCNA protein]

PMID:22077320 PMID:23882024 PMID:36286243

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

platelet derived growth factor subunit A

decreases expression

cupric oxide results in decreased expression of PDGFA mRNA

NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497

G

protein disulfide isomerase family A, member 3

decreases expression

cupric oxide results in decreased expression of PDIA3 protein

NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236

G

protein disulfide isomerase family A, member 4

decreases expression

cupric oxide results in decreased expression of PDIA4 protein

NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107

G

protein disulfide isomerase family A, member 6

decreases expression

cupric oxide results in decreased expression of PDIA6 protein

NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613

G

profilin 1

decreases expression

cupric oxide results in decreased expression of PFN1 protein

NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631

G

prohibitin 2

increases expression

cupric oxide results in increased expression of PHB2 protein

NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272

G

polyhomeotic homolog 3

increases expression

cupric oxide results in increased expression of PHC3 mRNA

NCBI chr 2:112,408,709...112,483,719
Ensembl chr 2:112,408,531...112,476,540

G

PHD finger protein 1

increases expression

cupric oxide results in increased expression of PHF1 mRNA

NCBI chr20:5,017,765...5,022,872
Ensembl chr20:5,017,893...5,022,871

G

putative homeodomain transcription factor 1

increases expression

cupric oxide results in increased expression of PHTF1 mRNA

NCBI chr 2:191,470,849...191,537,399
Ensembl chr 2:191,473,130...191,512,078

G

phosphatidylinositol binding clathrin assembly protein

increases expression

cupric oxide results in increased expression of PICALM protein

NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557

G

PIF1 5'-to-3' DNA helicase

decreases expression

cupric oxide results in decreased expression of PIF1 mRNA

NCBI chr 8:66,110,641...66,120,202
Ensembl chr 8:66,111,072...66,120,200

G

paired immunoglobin like type 2 receptor beta 2 like 8

increases expression

cupric oxide results in increased expression of ZNF37A mRNA

NCBI chr12:17,744,315...17,756,074
Ensembl chr12:17,752,830...17,755,922

G

PLAG1 like zinc finger 1

decreases expression

cupric oxide results in decreased expression of PLAGL1 mRNA

NCBI chr 1:7,477,295...7,517,229
Ensembl chr 1:7,477,177...7,517,228

G

polo-like kinase 2

decreases expression

cupric oxide results in decreased expression of PLK2 mRNA

NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947

G

pleiotropic regulator 1

increases expression

cupric oxide results in increased expression of PLRG1 mRNA

NCBI chr 2:168,408,139...168,424,470
Ensembl chr 2:168,408,124...168,424,522

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

cupric oxide results in increased expression of PMAIP1 mRNA

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

PMS1 homolog 1, mismatch repair system component

decreases expression

cupric oxide results in decreased expression of PMS1 mRNA

NCBI chr 9:48,229,403...48,340,237
Ensembl chr 9:48,253,410...48,340,237

G

patatin-like phospholipase domain containing 8

increases expression

cupric oxide results in increased expression of PNPLA8 mRNA

NCBI chr 6:61,329,810...61,391,736
Ensembl chr 6:61,329,810...61,391,734

G

podocalyxin-like

decreases expression

cupric oxide results in decreased expression of PODXL mRNA

NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899

G

DNA polymerase iota

decreases expression

cupric oxide results in decreased expression of POLI mRNA

NCBI chr18:64,116,774...64,134,373
Ensembl chr18:64,116,774...64,163,418

G

peptidylprolyl isomerase A

decreases expression

cupric oxide analog results in decreased expression of PPIA protein

NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601

G

peptidylprolyl isomerase B

increases expression

cupric oxide results in increased expression of PPIB protein

NCBI chr 8:66,603,877...66,609,734
Ensembl chr 8:66,603,861...66,630,428

G

protein phosphatase 1, regulatory subunit 3B

increases expression

cupric oxide results in increased expression of PPP1R3B mRNA

NCBI chr16:56,830,011...56,842,395
Ensembl chr16:56,829,660...56,842,406

G

protein phosphatase 2 scaffold subunit A alpha

increases expression

cupric oxide results in increased expression of PPP2R1A protein

NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129

G

peroxiredoxin 1

increases expression

cupric oxide analog results in increased expression of PRDX1 protein

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

peroxiredoxin 2

increases expression

cupric oxide results in increased expression of PRDX2 protein

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

peroxiredoxin 6

increases expression
decreases expression

cupric oxide results in increased expression of PRDX6 protein
cupric oxide results in decreased expression of PRDX6 protein

PMID:23882024 PMID:25470785

NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355

G

protein kinase cAMP-dependent type I regulatory subunit alpha

decreases phosphorylation

cupric oxide results in decreased phosphorylation of PRKAR1A protein

NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041

G

PRKCSH beta subunit of glucosidase II

decreases expression

cupric oxide results in decreased expression of PRKCSH protein

NCBI chr 8:20,534,787...20,546,493
Ensembl chr 8:20,534,880...20,546,492

G

prolactin

multiple interactions

[cupric oxide co-treated with lead oxide] results in increased expression of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

PROP paired-like homeobox 1

increases expression

cupric oxide results in increased expression of PROP1 mRNA

NCBI chr10:35,271,959...35,274,434
Ensembl chr10:35,271,973...35,274,434

G

pre-mRNA processing factor 18

increases expression

cupric oxide results in increased expression of PRPF18 mRNA

NCBI chr17:73,630,560...73,661,210
Ensembl chr17:73,630,571...73,690,979

G

serine protease 23

decreases expression

cupric oxide results in decreased expression of PRSS23 mRNA

NCBI chr 1:143,402,725...143,422,182
Ensembl chr 1:143,401,396...143,422,091

G

protein serine kinase H1

decreases expression

cupric oxide results in decreased expression of PSKH1 mRNA

NCBI chr19:33,794,919...33,827,040
Ensembl chr19:33,794,935...33,827,032

G

proline and serine rich coiled-coil 1

decreases expression

cupric oxide results in decreased expression of PSRC1 mRNA

NCBI chr 2:196,022,361...196,026,874
Ensembl chr 2:196,022,361...196,026,874

G

protein tyrosine phosphatase, non-receptor type 13

decreases expression

cupric oxide results in decreased expression of PTPN13 mRNA

NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563

G

PTTG1 regulator of sister chromatid separation, securin

decreases expression

cupric oxide results in decreased expression of PTTG1 mRNA

NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837

G

RAB1B, member RAS oncogene family

decreases expression

cupric oxide results in decreased expression of RAB1B protein

NCBI chr 1:202,405,759...202,413,850
Ensembl chr 1:202,405,759...202,413,868
Ensembl chr X:202,405,759...202,413,868

G

Rac GTPase-activating protein 1

decreases expression

cupric oxide results in decreased expression of RACGAP1 mRNA

NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831

G

RAD23 homolog A, nucleotide excision repair protein

decreases phosphorylation

cupric oxide results in decreased phosphorylation of RAD23A protein

NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695

G

RAD51 recombinase

increases expression

cupric oxide results in increased expression of RAD51 mRNA

NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035

G

Rap guanine nucleotide exchange factor 6

decreases expression

cupric oxide results in decreased expression of RAPGEF6 mRNA

NCBI chr10:38,655,854...38,824,227
Ensembl chr10:38,655,867...38,823,211

G

RB binding protein 6, ubiquitin ligase

increases expression

cupric oxide results in increased expression of RBBP6 mRNA

NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678

G

RB binding protein 8, endonuclease

decreases expression

cupric oxide results in decreased expression of RBBP8 mRNA

NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846

G

regulatory factor X4

increases phosphorylation

cupric oxide results in increased phosphorylation of RFX4 protein

NCBI chr 7:18,853,065...19,015,378
Ensembl chr 7:18,853,322...19,014,967

G

RIO kinase 3

increases expression

cupric oxide results in increased expression of RIOK3 mRNA

NCBI chr18:3,327,776...3,353,350
Ensembl chr18:3,327,776...3,353,343

G

Ras-like without CAAX 1

increases expression

cupric oxide results in increased expression of RIT1 mRNA

NCBI chr 2:174,180,742...174,195,455
Ensembl chr 2:174,180,848...174,195,455

G

RLF zinc finger

increases expression

cupric oxide results in increased expression of RLF mRNA

NCBI chr 5:134,711,612...134,767,274
Ensembl chr 5:134,711,619...134,767,257

G

ring finger protein, LIM domain interacting

increases expression

cupric oxide results in increased expression of RLIM mRNA

NCBI chr X:68,983,259...69,004,368
Ensembl chr X:68,988,375...69,004,271

G

ring finger protein 11

increases expression

cupric oxide results in increased expression of RNF11 mRNA

NCBI chr 5:124,212,433...124,243,125
Ensembl chr 5:124,212,445...124,234,750

G

ring finger protein 185

increases expression

cupric oxide results in increased expression of RNF185 mRNA

NCBI chr14:78,292,517...78,329,832
Ensembl chr14:78,292,516...78,329,864

G

RNA (guanine-7-) methyltransferase

increases expression

cupric oxide results in increased expression of RNMT mRNA

NCBI chr18:61,886,230...61,909,775
Ensembl chr18:61,886,292...61,909,775

G

receptor tyrosine kinase-like orphan receptor 1

decreases expression

cupric oxide results in decreased expression of ROR1 mRNA

NCBI chr 5:114,744,311...115,088,155
Ensembl chr 5:114,744,304...115,088,155

G

RP2 activator of ARL3 GTPase

increases expression

cupric oxide results in increased expression of RP2 mRNA

NCBI chr X:1,872,582...1,916,704
Ensembl chr X:1,873,306...1,916,688

G

ribosomal protein lateral stalk subunit P0

increases expression

cupric oxide results in increased expression of RPLP0 protein
cupric oxide analog results in increased expression of RPLP0 protein

PMID:23882024 PMID:25470785

NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632

G

ribosomal protein lateral stalk subunit P1

increases expression

cupric oxide results in increased expression of RPLP1 protein

NCBI chr 8:62,394,008...62,395,341
Ensembl chr 8:62,393,177...62,395,339

G

ribosomal protein S2

increases expression

cupric oxide results in increased expression of RPS2 protein

NCBI chr10:13,747,316...13,749,165
Ensembl chr10:13,747,301...13,749,163

G

ribosomal protein S3

increases expression

cupric oxide results in increased expression of RPS3 protein

NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680

G

ribosomal protein S5

increases expression

cupric oxide results in increased expression of RPS5 protein

NCBI chr 1:73,538,776...73,543,073
Ensembl chr 1:73,538,776...73,543,073

G

ribosomal protein S7

decreases expression

cupric oxide results in decreased expression of RPS7 protein

NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145

G

ribosomal protein SA

increases expression

cupric oxide results in increased expression of RPSA protein

NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247

G

RNA pseudouridine synthase D4

increases expression

cupric oxide results in increased expression of RPUSD4 mRNA

NCBI chr 8:33,617,384...33,626,873
Ensembl chr 8:33,617,379...33,626,873

G

ribonucleotide reductase regulatory subunit M2

decreases expression

cupric oxide results in decreased expression of RRM2 mRNA

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

RING1 and YY1 binding protein

increases expression

cupric oxide results in increased expression of RYBP mRNA

NCBI chr 4:132,876,260...132,928,328
Ensembl chr 4:132,876,361...132,928,316

G

SAS-6 centriolar assembly protein

decreases expression

cupric oxide results in decreased expression of SASS6 mRNA

NCBI chr 2:204,546,660...204,578,930
Ensembl chr 2:204,546,660...204,578,927

G

spermidine/spermine N1-acetyl transferase 1

increases expression

cupric oxide results in increased expression of SAT1 mRNA

NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813

G

strawberry notch homolog 1

increases expression

cupric oxide results in increased expression of SBNO1 mRNA

NCBI chr12:32,175,176...32,234,200
Ensembl chr12:32,185,485...32,230,158

G

Scm polycomb group protein like 1

increases expression

cupric oxide results in increased expression of SCML1 mRNA

NCBI chr X:32,893,100...32,912,686
Ensembl chr X:32,894,327...32,911,366

G

sodium voltage-gated channel alpha subunit 10

decreases phosphorylation

cupric oxide results in decreased phosphorylation of SCN10A protein

NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614

G

SEC14-like lipid binding 1

increases expression

cupric oxide results in increased expression of SEC14L1 mRNA

NCBI chr10:102,319,920...102,367,070
Ensembl chr10:102,319,920...102,367,068

G

SEC61 translocon subunit alpha 2

increases expression

cupric oxide results in increased expression of SEC61A2 mRNA

NCBI chr17:72,407,574...72,445,630
Ensembl chr17:72,407,671...72,434,494

G

selenoprotein P

decreases expression

cupric oxide results in decreased expression of SELENOP mRNA

NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852

G

serpin family E member 1

increases expression
multiple interactions

cupric oxide results in increased expression of SERPINE1 mRNA; cupric oxide results in increased expression of SERPINE1 protein
SB 203580 inhibits the reaction [cupric oxide results in increased expression of SERPINE1 mRNA]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

SET binding protein 1

decreases expression

cupric oxide results in decreased expression of SETBP1 mRNA

NCBI chr18:72,190,542...72,551,272
Ensembl chr18:72,191,035...72,552,556

G

SET domain containing 2, histone lysine methyltransferase

decreases phosphorylation

cupric oxide results in decreased phosphorylation of SETD2 protein

NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489

G

splicing factor proline and glutamine rich

increases expression

cupric oxide results in increased expression of SFPQ protein

NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472

G

secreted frizzled-related protein 1

decreases expression

cupric oxide results in decreased expression of SFRP1 mRNA

NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286

G

SIM bHLH transcription factor 2

decreases expression

cupric oxide results in decreased expression of SIM2 mRNA

NCBI chr11:33,414,218...33,453,663
Ensembl chr11:33,414,218...33,453,663

G

SIN3 transcription regulator family member B

increases expression

cupric oxide results in increased expression of SIN3B mRNA

NCBI chr16:17,123,277...17,159,978
Ensembl chr16:17,123,434...17,159,978

G

sirtuin 6

increases expression

cupric oxide results in increased expression of SIRT6 mRNA

NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914

G

solute carrier family 25 member 3

decreases expression

cupric oxide results in decreased expression of SLC25A3 protein

NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:25,586,725...25,667,727

G

solute carrier family 25, member 44

increases expression

cupric oxide results in increased expression of SLC25A44 mRNA

NCBI chr 2:173,868,317...173,883,137
Ensembl chr 2:173,868,320...173,883,020

G

solute carrier family 27 member 2

decreases expression

cupric oxide results in decreased expression of SLC27A2 mRNA

NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208

G

solute carrier family 30 member 1

increases expression

cupric oxide results in increased expression of SLC30A1 mRNA

PMID:24343273 PMID:32285662

NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910

G

solute carrier family 31 member 1

increases expression

cupric oxide analog results in increased expression of SLC31A1 mRNA; cupric oxide analog results in increased expression of SLC31A1 protein

NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228

G

SLU7 homolog, splicing factor

increases expression

cupric oxide results in increased expression of SLU7 mRNA

NCBI chr10:27,908,325...27,923,784
Ensembl chr10:27,908,396...27,923,349

G

snail family transcriptional repressor 1

increases expression

cupric oxide results in increased expression of SNAI1 mRNA

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

staphylococcal nuclease and tudor domain containing 1

increases expression

cupric oxide results in increased expression of SND1 protein

NCBI chr 4:57,095,205...57,494,501
Ensembl chr 4:57,095,208...57,530,843

G

Smad nuclear interacting protein 1

increases expression

cupric oxide results in increased expression of SNIP1 mRNA

NCBI chr 5:137,328,371...137,335,846
Ensembl chr 5:137,328,371...137,335,845

G

sorting nexin 8

increases expression

cupric oxide results in increased expression of SNX8 mRNA

NCBI chr12:14,251,829...14,300,435
Ensembl chr12:14,251,859...14,300,432

G

superoxide dismutase 1

multiple interactions
decreases expression
increases expression

trans-sodium crocetinate inhibits the reaction [cupric oxide results in decreased expression of SOD1 mRNA]
cupric oxide results in increased expression of SOD1 mRNA

PMID:25701151 PMID:32285662

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases expression
multiple interactions
decreases expression

cupric oxide results in increased expression of SOD2 mRNA
trans-sodium crocetinate inhibits the reaction [cupric oxide results in decreased expression of SOD2 mRNA]

PMID:22077320 PMID:25701151 PMID:32285662

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

SRY-box transcription factor 8

increases expression

cupric oxide results in increased expression of SOX8 mRNA

NCBI chr10:14,584,829...14,589,818
Ensembl chr10:14,584,829...14,589,818

G

Sp1 transcription factor

increases expression

cupric oxide results in increased expression of SP1 mRNA

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

spectrin, alpha, non-erythrocytic 1

increases expression

cupric oxide results in increased expression of SPTAN1 protein

NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046

G

spectrin, beta, non-erythrocytic 1

decreases expression

cupric oxide results in decreased expression of SPTBN1 mRNA

NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507

G

sterol regulatory element binding transcription factor 2

increases expression

cupric oxide results in increased expression of SREBF2 mRNA

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

SLIT-ROBO Rho GTPase activating protein 2

decreases expression

cupric oxide results in decreased expression of SRGAP2 mRNA

NCBI chr13:42,745,956...42,967,091
Ensembl chr13:42,745,947...42,967,058

G

ST13, Hsp70 interacting protein

increases expression

cupric oxide results in increased expression of ST13 mRNA

NCBI chr 7:112,891,007...112,925,727
Ensembl chr 7:112,844,375...112,925,945

G

serine/threonine kinase receptor associated protein

decreases expression

cupric oxide analog results in decreased expression of STRAP protein

NCBI chr 4:170,646,042...170,660,291
Ensembl chr 4:170,646,001...170,660,828

G

SPT4 homolog, DSIF elongation factor subunit

increases expression

cupric oxide results in increased expression of SUPT4H1 mRNA

NCBI chr10:72,539,323...72,545,582
Ensembl chr10:72,539,382...72,545,831

G

TATA-box binding protein associated factor 13

increases expression

cupric oxide results in increased expression of TAF13 mRNA

NCBI chr 2:196,205,219...196,215,882
Ensembl chr 2:196,205,243...196,215,878

G

TATA-box binding protein associated factor 7

increases expression

cupric oxide results in increased expression of TAF7 mRNA

NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134

G

TATA-box binding protein associated factor 8

increases expression

cupric oxide results in increased expression of TAF8 mRNA

NCBI chr 9:13,491,892...13,511,713
Ensembl chr 9:13,491,937...13,511,717

G

transgelin 2

increases expression

cupric oxide results in increased expression of TAGLN2 protein

NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972

G

TBC1 domain family, member 15

increases expression

cupric oxide results in increased expression of TBC1D15 mRNA

NCBI chr 7:50,804,553...50,860,272
Ensembl chr 7:50,804,012...50,860,175

G

TBC1 domain family member 9B

decreases expression

cupric oxide results in decreased expression of TBC1D9B mRNA

NCBI chr10:34,459,930...34,497,146
Ensembl chr10:34,459,953...34,497,145

G

thymine-DNA glycosylase

increases expression

cupric oxide results in increased expression of TDG mRNA

NCBI chr 7:21,077,853...21,097,617
Ensembl chr 7:21,077,853...21,097,567

G

TEA domain transcription factor 1

increases expression

cupric oxide results in increased expression of TEAD1 mRNA

NCBI chr 1:166,791,900...167,010,591
Ensembl chr 1:166,792,628...167,003,369

G

tuftelin interacting protein 11

increases expression

cupric oxide results in increased expression of TFIP11 mRNA

NCBI chr12:44,299,619...44,311,851
Ensembl chr12:44,299,622...44,311,855

G

transforming growth factor, beta 2

decreases expression

cupric oxide results in decreased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

THAP domain containing 1

increases expression

cupric oxide results in increased expression of THAP1 mRNA

NCBI chr16:65,905,348...65,909,942
Ensembl chr16:65,904,230...65,909,942

G

thrombospondin type 1 domain containing 7A

decreases expression

cupric oxide results in decreased expression of THSD7A mRNA

NCBI chr 4:40,461,124...40,899,345
Ensembl chr 4:40,460,814...40,899,583

G

translocase of inner mitochondrial membrane 10B

increases expression

cupric oxide results in increased expression of TIMM10B mRNA

NCBI chr 1:159,980,525...159,983,371
Ensembl chr 1:159,980,484...159,981,642

G

transketolase

increases expression

cupric oxide results in increased expression of TKT protein

NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698

G

talin rod domain containing 1

decreases expression

cupric oxide results in decreased expression of TLNRD1 mRNA

NCBI chr 1:137,864,340...137,866,359
Ensembl chr 1:137,864,343...137,866,359

G

transmembrane p24 trafficking protein 4

decreases expression

cupric oxide results in decreased expression of TMED4 protein

NCBI chr14:81,125,049...81,129,646
Ensembl chr14:81,125,053...81,129,631

G

transmembrane protein 171

decreases expression

cupric oxide results in decreased expression of TMEM171 mRNA

NCBI chr 2:30,035,278...30,045,996
Ensembl chr 2:30,035,278...30,045,049

G

tropomodulin 3

increases expression

cupric oxide results in increased expression of TMOD3 protein

NCBI chr 8:76,248,978...76,310,855
Ensembl chr 8:76,248,979...76,310,977

G

thymosin beta 4, X-linked

decreases expression

cupric oxide results in decreased expression of TMSB4X mRNA

NCBI chr X:27,144,666...27,146,667
Ensembl chr X:27,128,610...27,146,667

G

tumor necrosis factor

multiple interactions

cupric oxide results in increased expression of and results in increased secretion of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tensin 3

decreases expression

cupric oxide results in decreased expression of TNS3 mRNA

NCBI chr14:83,173,649...83,405,671
Ensembl chr14:83,173,649...83,405,998

G

DNA topoisomerase II alpha

decreases expression

cupric oxide results in decreased expression of TOP2A mRNA

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

decreases expression
multiple interactions

cupric oxide results in decreased expression of TP53 mRNA
cupric oxide analog results in decreased phosphorylation of and results in decreased expression of TP53 protein
cupric oxide analog results in decreased phosphorylation of and results in decreased expression of TRP53 protein

PMID:22077320 PMID:25336953 PMID:32285662

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tropomyosin 1

decreases expression

cupric oxide results in decreased expression of TPM1 mRNA

NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802

G

TPX2, microtubule nucleation factor

decreases expression

cupric oxide results in decreased expression of TPX2 mRNA

NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468

G

TNF receptor associated factor 7

decreases expression

cupric oxide results in decreased expression of TRAF7 mRNA

NCBI chr10:13,533,570...13,552,290
Ensembl chr10:13,533,570...13,552,203

G

translocation associated membrane protein 1

decreases expression

cupric oxide results in decreased expression of TRAM1 mRNA

NCBI chr 5:5,642,579...5,667,666
Ensembl chr 5:5,642,546...5,686,971

G

tribbles pseudokinase 3

increases expression

cupric oxide results in increased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

G

tripartite motif-containing 14

decreases expression

cupric oxide results in decreased expression of TRIM14 mRNA

NCBI chr 5:60,800,568...60,824,858
Ensembl chr 5:60,800,032...60,824,858

G

tripartite motif-containing 59

decreases expression

cupric oxide results in decreased expression of TRIM59 mRNA

NCBI chr 2:153,269,210...153,281,185
Ensembl chr 2:153,268,584...153,281,031

G

tripartite motif containing 6

decreases expression

cupric oxide results in decreased expression of TRIM6 mRNA

NCBI chr 1:158,683,746...158,696,936
Ensembl chr 1:158,683,746...158,696,914

G

TRIO and F-actin binding protein

decreases expression

cupric oxide results in decreased expression of TRIOBP mRNA

NCBI chr 7:110,505,916...110,569,301
Ensembl chr 7:110,506,248...110,562,474

G

tetratricopeptide repeat domain 1

increases expression

cupric oxide results in increased expression of TTC1 mRNA

NCBI chr10:28,202,325...28,227,464
Ensembl chr10:28,202,325...28,227,472

G

transcription termination factor 1

increases expression

cupric oxide results in increased expression of TTF1 mRNA

NCBI chr 3:12,384,626...12,409,257
Ensembl chr 3:12,384,655...12,409,257

G

tubulin, alpha 3B

decreases expression

cupric oxide results in decreased expression of TUBA3D mRNA

NCBI chr 4:178,588,779...178,594,328
Ensembl chr 4:178,588,779...178,594,326

G

tubulin, beta 2B class IIb

decreases expression

cupric oxide results in decreased expression of TUBB2B mRNA

NCBI chr17:30,747,734...30,750,781
Ensembl chr17:30,747,734...30,750,638

G

tubulin, beta 6 class V

decreases expression

cupric oxide results in decreased expression of TUBB6 mRNA; cupric oxide results in decreased expression of TUBB6 protein

PMID:22077320 PMID:25470785

NCBI chr18:60,943,394...60,953,031
Ensembl chr18:60,943,375...60,954,418

G

ubiquitin-like modifier activating enzyme 1

increases expression

cupric oxide results in increased expression of UBA1 protein

NCBI chr X:1,508,700...1,530,677
Ensembl chr X:1,508,666...1,530,636

G

ubiquitin-conjugating enzyme E2L 3

increases expression

cupric oxide results in increased expression of UBE2L3 protein

NCBI chr11:83,797,722...83,838,862
Ensembl chr11:83,797,722...83,838,862

G

ubiquitin-conjugating enzyme E2T

decreases expression

cupric oxide results in decreased expression of UBE2T mRNA

NCBI chr13:46,403,352...46,413,854
Ensembl chr13:46,403,375...46,414,835

G

ubiquitin C-terminal hydrolase L1

decreases activity

cupric oxide results in decreased activity of UCHL1 protein

NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590

G

U2AF homology motif kinase 1

increases expression

cupric oxide results in increased expression of UHMK1 mRNA

NCBI chr13:82,396,646...82,416,292
Ensembl chr13:82,401,187...82,416,292

G

ubiquitin-like with PHD and ring finger domains 1

decreases expression

cupric oxide results in decreased expression of UHRF1 mRNA

NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631

G

ubiquinol-cytochrome c reductase core protein 1

increases expression

cupric oxide analog results in increased expression of UQCRC1 protein

NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480

G

ubiquitin specific peptidase 15

increases expression

cupric oxide results in increased expression of USP15 mRNA

NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721

G

ubiquitin specific peptidase 32

increases expression

cupric oxide results in increased expression of USP32 mRNA

NCBI chr10:69,855,895...70,029,075
Ensembl chr10:69,855,885...70,029,137

G

UTP11, small subunit processome component

increases expression

cupric oxide results in increased expression of UTP11 mRNA

NCBI chr 5:136,931,279...136,946,164
Ensembl chr 5:136,931,008...136,946,191

G

utrophin

decreases expression

cupric oxide results in decreased expression of UTRN mRNA

NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313

G

vascular endothelial growth factor A

increases expression

cupric oxide results in increased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

decreases expression

cupric oxide analog results in decreased expression of VIM protein

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

Y box binding protein 1

increases expression

cupric oxide results in increased expression of YBX1 protein

NCBI chr 5:132,882,137...132,898,885
Ensembl chr 5:132,882,145...132,898,862

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

decreases expression

cupric oxide analog results in decreased expression of YWHAB protein

NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma

decreases expression

cupric oxide analog results in decreased expression of YWHAG protein

NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta

decreases expression

cupric oxide results in decreased expression of YWHAH mRNA

NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

decreases expression

cupric oxide analog results in decreased expression of YWHAZ protein

NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668

G

zinc finger and BTB domain containing 43

increases expression

cupric oxide results in increased expression of ZBTB43 mRNA

NCBI chr 3:16,744,535...16,763,854
Ensembl chr 3:16,744,535...16,763,909

G

zinc finger and BTB domain containing 5

increases expression

cupric oxide results in increased expression of ZBTB5 mRNA

NCBI chr 5:59,244,132...59,265,461
Ensembl chr 5:59,243,307...59,265,426

G

zinc finger protein 110

increases expression

cupric oxide results in increased expression of ZNF274 mRNA

NCBI chr 1:73,445,303...73,461,112
Ensembl chr 1:73,445,336...73,461,086

G

zinc finger protein 12

increases expression

cupric oxide results in increased expression of ZNF12 mRNA

NCBI chr12:11,316,971...11,330,498
Ensembl chr12:11,316,872...11,330,558

G

zinc finger protein 143

increases expression

cupric oxide results in increased expression of ZNF143 mRNA

NCBI chr 1:164,109,041...164,144,902
Ensembl chr 1:164,109,116...164,144,902

G

zinc finger protein 185

decreases expression

cupric oxide results in decreased expression of ZNF185 mRNA

NCBI chr X:150,831,869...150,877,652
Ensembl chr X:150,831,862...150,874,810

G

zinc finger protein 236

increases expression

cupric oxide results in increased expression of ZNF236 mRNA

NCBI chr18:75,976,478...76,072,428
Ensembl chr18:75,978,231...76,073,737

G

zinc finger protein 277

increases expression

cupric oxide results in increased expression of ZNF277 mRNA

NCBI chr 6:57,383,454...57,512,785
Ensembl chr 6:57,383,951...57,512,765

G

zinc finger protein 286A

increases expression

cupric oxide results in increased expression of ZNF286A mRNA

NCBI chr10:47,450,469...47,461,267
Ensembl chr10:47,450,469...47,463,258

G

zinc finger protein 34

increases expression

cupric oxide results in increased expression of ZNF34 mRNA

NCBI chr 5:157,509,762...157,513,970
Ensembl chr 5:157,509,451...157,599,926

G

zinc finger protein 35

increases expression

cupric oxide results in increased expression of ZNF79 mRNA

NCBI chr18:15,268,852...15,284,334
Ensembl chr18:15,268,814...15,285,088

G

zinc finger protein 36, C3H type-like 1

decreases expression

cupric oxide results in decreased expression of ZFP36L1 mRNA

NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748

G

zinc finger protein 36, C3H type-like 2

decreases expression

cupric oxide results in decreased expression of ZFP36L2 mRNA

NCBI chr 6:10,490,032...10,494,073
Ensembl chr 6:10,490,032...10,494,064

G

zinc finger protein 394

increases expression

cupric oxide results in increased expression of ZNF394 mRNA

NCBI chr12:9,409,047...9,417,228
Ensembl chr12:9,409,078...9,417,246

G

zinc finger protein 46

increases expression

cupric oxide results in increased expression of ZNF436 mRNA

NCBI chr 5:148,519,398...148,529,903
Ensembl chr 5:148,520,855...148,529,459

G

zinc finger protein 473

increases expression

cupric oxide results in increased expression of ZNF473 mRNA

NCBI chr 1:95,222,683...95,243,328
Ensembl chr 1:95,223,433...95,243,325

G

zinc finger protein 507

increases expression

cupric oxide results in increased expression of ZNF507 mRNA

NCBI chr 1:88,435,787...88,468,577
Ensembl chr 1:88,438,246...88,468,518

G

zinc finger protein 512

increases expression

cupric oxide results in increased expression of ZNF512 mRNA

NCBI chr 6:24,976,903...25,007,913
Ensembl chr 6:24,976,906...25,007,819

G

zinc finger protein 560

increases expression

cupric oxide results in increased expression of ZNF121 mRNA

NCBI chr 8:18,900,142...18,914,444
Ensembl chr 8:18,900,528...18,914,442

G

zinc finger protein 707

increases expression

cupric oxide results in increased expression of ZNF707 mRNA

NCBI chr 7:107,679,597...107,686,556
Ensembl chr 7:107,650,217...107,703,459

G

zinc finger protein 719

increases expression

cupric oxide results in increased expression of ZNF175 mRNA

NCBI chr 1:94,009,957...94,027,342
Ensembl chr 1:93,992,492...94,023,023

G

zinc finger protein 84

increases expression

cupric oxide results in increased expression of ZNF565 mRNA

NCBI chr 1:84,987,352...85,015,478
Ensembl chr 1:85,004,920...85,015,478
Ensembl chr 1:85,004,920...85,015,478

G

zinc finger protein 780B

increases expression

cupric oxide results in increased expression of ZNF780B mRNA

NCBI chr 1:83,009,174...83,030,463
Ensembl chr 1:83,009,189...83,082,107

G

zinc finger protein 8

increases expression

cupric oxide results in increased expression of ZNF8 mRNA

NCBI chr 1:73,498,526...73,511,929
Ensembl chr 1:73,498,491...73,511,119

G

zinc finger RANBP2-type containing 2

increases expression

cupric oxide results in increased expression of ZRANB2 mRNA

NCBI chr 2:246,573,110...246,586,942
Ensembl chr 2:246,573,166...246,586,942

G

zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2

increases expression

cupric oxide results in increased expression of ZRSR2 mRNA

NCBI chr X:30,547,424...30,571,613
Ensembl chr X:30,547,536...30,570,125

G

zinc finger and SCAN domain containing 2

increases expression

cupric oxide results in increased expression of ZSCAN2 mRNA

NCBI chr 1:134,833,701...134,848,957
Ensembl chr 1:134,833,871...134,848,952

G

zinc finger and SCAN domain containing 20

increases expression

cupric oxide results in increased expression of ZSCAN20 mRNA

NCBI chr 5:140,926,596...140,956,285
Ensembl chr 5:140,930,689...140,956,336

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19890
chemical entity	19867
atom	19888
nonmetal atom	19789
carbon atom	19743
organic molecular entity	19743
CU-O LINKAGE	530
Path 2
Term	Annotations
CHEBI ontology	19890
subatomic particle	19867
composite particle	19888
hadron	19888
baryon	19888
nucleon	19867
atomic nucleus	19888
atom	19888
main group element atom	19806
p-block element atom	19806
carbon group element atom	19746
carbon atom	19743
organic molecular entity	19743
CU-O LINKAGE	530

paths to the root