Traf7 (TNF receptor associated factor 7) - Rat Genome Database

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Gene: Traf7 (TNF receptor associated factor 7) Rattus norvegicus
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Symbol: Traf7
Name: TNF receptor associated factor 7
RGD ID: 1559653
Description: Predicted to enable ubiquitin protein ligase activity. Involved in positive regulation of neuron apoptotic process. Predicted to be located in several cellular components, including cytosol; perinuclear region of cytoplasm; and plasma membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in adenomatoid tumor; hepatocellular carcinoma; and peritoneal mesothelioma. Orthologous to human TRAF7 (TNF receptor associated factor 7); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase TRAF7; LOC360491; RGD1559653; similar to ring finger and WD repeat domain 1 isoform 1; Tnf receptor-associated factor 7; TNF receptor-associated factor 7, E3 ubiquitin protein ligase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,038,117 - 14,056,832 (-)NCBIGRCr8
mRatBN7.21013,533,570 - 13,552,290 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,533,570 - 13,552,203 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,280,130 - 18,298,622 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,768,975 - 17,787,467 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,268,162 - 13,286,654 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,874,444 - 13,893,090 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,874,456 - 13,892,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,691,429 - 13,710,062 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,760,687 - 13,779,228 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1013,213,849 - 13,232,354 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Traf7Ratadenomatoid tumor  ISOTRAF7 (Homo sapiens)151356962DNA:missense mutations:multipleRGD 
Traf7Rathepatocellular carcinoma treatmentISOTRAF7 (Homo sapiens)151356961 RGD 
Traf7Rathepatocellular carcinoma  ISOTRAF7 (Homo sapiens)151356961mRNA:increased expression:liverRGD 
Traf7Ratperitoneal mesothelioma  ISOTRAF7 (Homo sapiens)151356964DNA:missense mutations:multipleRGD 
Traf7RatSpinal Cord Injuries  IEP 151356968mRNA and protein:increased expression:spinal cordRGD 
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Original Reference(s)
Traf7Ratautosomal dominant polycystic kidney disease  ISOTRAF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal dominant polycystic kidney diseaseClinVarPMID:25741868
Traf7RatCardiac, Facial, and Digital Anomalies with Developmental Delay  ISOTRAF7 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Traf7RatCardiac, Facial, and Digital Anomalies with Developmental Delay  ISOTRAF7 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Traf7Ratdevelopmental and epileptic encephalopathy 1  ISOTRAF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 1ClinVarPMID:28492532 and PMID:30866059
Traf7RatDevelopmental Disabilities  ISOTRAF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Global developmental delayClinVarPMID:25741868
Traf7Ratendometrial carcinoma  ISOTRAF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Endometrial carcinomaClinVar 
Traf7Ratepilepsy  ISOTRAF7 (Homo sapiens)8554872ClinVar Annotator: match by term: EpilepsyClinVarPMID:28492532
Traf7Ratgenetic disease  ISOTRAF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
Traf7RatIdiopathic Generalized Epilepsy  ISOTRAF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Idiopathic generalized epilepsyClinVarPMID:28492532
Traf7Ratshort-rib thoracic dysplasia 9 with or without polydactyly  ISOTRAF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Saldino-Mainzer syndromeClinVarPMID:28492532
Traf7Rattuberous sclerosis 2  ISOTRAF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Tuberous sclerosis 2ClinVarPMID:11112665 more ...
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Original Reference(s)
Traf7Ratmalignant mesothelioma  ISOTRAF7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26928227
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Traf7RatCardiac, Facial, and Digital Anomalies with Developmental Delay  ISOTRAF7 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Traf7Rat1,2-dimethylhydrazine multiple interactionsISOTraf7 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of TRAF7 mRNACTDPMID:22206623
Traf7Rat17alpha-ethynylestradiol affects expressionISOTraf7 (Mus musculus)6480464Ethinyl Estradiol affects the expression of TRAF7 mRNACTDPMID:17555576
Traf7Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTraf7 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TRAF7 mRNACTDPMID:21570461 and PMID:24680724
Traf7Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of TRAF7 mRNACTDPMID:34747641
Traf7Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of TRAF7 mRNACTDPMID:21346803
Traf7Rat3,4-methylenedioxymethamphetamine increases expressionISOTraf7 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of TRAF7 mRNACTDPMID:20188158
Traf7Ratall-trans-retinoic acid decreases expressionISOTRAF7 (Homo sapiens)6480464Tretinoin results in decreased expression of TRAF7 mRNACTDPMID:33167477
Traf7Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of TRAF7 mRNACTDPMID:16483693
Traf7Ratbenzo[a]pyrene increases expressionISOTraf7 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of TRAF7 mRNACTDPMID:22228805
Traf7Ratbenzo[a]pyrene affects methylationISOTRAF7 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of TRAF7 5' UTRCTDPMID:27901495
Traf7Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of TRAF7 mRNACTDPMID:25181051 more ...
Traf7Ratbisphenol A increases expressionISOTRAF7 (Homo sapiens)6480464bisphenol A results in increased expression of TRAF7 mRNACTDPMID:29275510
Traf7Ratbisphenol F decreases expressionISOTraf7 (Mus musculus)6480464bisphenol F results in decreased expression of TRAF7 mRNACTDPMID:38685157
Traf7Ratcadmium atom multiple interactionsISOTRAF7 (Homo sapiens)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TRAF7 mRNACTDPMID:35301059
Traf7Ratcadmium dichloride decreases expressionISOTRAF7 (Homo sapiens)6480464Cadmium Chloride results in decreased expression of TRAF7 mRNACTDPMID:38568856
Traf7Ratcadmium dichloride multiple interactionsISOTRAF7 (Homo sapiens)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TRAF7 mRNACTDPMID:35301059
Traf7Ratcaffeine increases phosphorylationISOTRAF7 (Homo sapiens)6480464Caffeine results in increased phosphorylation of TRAF7 proteinCTDPMID:35688186
Traf7Ratchlorpyrifos increases expressionISOTraf7 (Mus musculus)6480464Chlorpyrifos results in increased expression of TRAF7 mRNACTDPMID:32715474 and PMID:37019170
Traf7Ratcisplatin increases expressionISOTraf7 (Mus musculus)6480464Cisplatin results in increased expression of TRAF7 mRNACTDPMID:21151649
Traf7Ratcisplatin multiple interactionsISOTRAF7 (Homo sapiens)6480464Cisplatin promotes the reaction [jinfukang results in increased expression of TRAF7 mRNA] and jinfukang promotes the reaction [Cisplatin results in increased expression of TRAF7 mRNA]CTDPMID:27392435

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Biological Process
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Original Reference(s)
Traf7Ratapoptotic process involved_inIBAPANTHER:PTN008571510 and UniProtKB:Q6Q0C01600115GO_REF:0000033GO_CentralGO_REF:0000033
Traf7Ratapoptotic process acts_upstream_of_or_withinISOTRAF7 (Homo sapiens)1624291 PMID:15001576RGDPMID:15001576
Traf7Ratapoptotic process acts_upstream_of_or_withinIEAUniProtKB:Q6Q0C0 and ensembl:ENSP000003189441600115GO_REF:0000107EnsemblGO_REF:0000107
Traf7Ratcellular response to interleukin-6 acts_upstream_of_or_withinISOTraf7 (Mus musculus)1624291 PMID:16162816RGDPMID:16162816
Traf7Ratnegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOTraf7 (Mus musculus)1624291 PMID:16162816RGDPMID:16162816
Traf7Ratpositive regulation of apoptotic signaling pathway involved_inISOTRAF7 (Homo sapiens)1624291 PMID:15001576RGDPMID:15001576
Traf7Ratpositive regulation of apoptotic signaling pathway involved_inIEAUniProtKB:Q6Q0C0 and ensembl:ENSP000003189441600115GO_REF:0000107EnsemblGO_REF:0000107
Traf7Ratpositive regulation of MAPK cascade acts_upstream_of_or_withinISOTRAF7 (Homo sapiens)1624291 PMID:15001576RGDPMID:15001576
Traf7Ratpositive regulation of MAPK cascade acts_upstream_of_or_withinIEAUniProtKB:Q6Q0C0 and ensembl:ENSP000003189441600115GO_REF:0000107EnsemblGO_REF:0000107
Traf7Ratpositive regulation of MAPK cascade involved_inIBAPANTHER:PTN008571510 and UniProtKB:Q6Q0C01600115GO_REF:0000033GO_CentralGO_REF:0000033
Traf7Ratpositive regulation of MAPK cascade involved_inISOTRAF7 (Homo sapiens)1624291 PMID:14743216RGDPMID:14743216
Traf7Ratpositive regulation of neuron apoptotic process  IMP 151356968 RGD 
Traf7Ratpositive regulation of protein sumoylation acts_upstream_of_or_withinISOTraf7 (Mus musculus)1624291 PMID:16162816RGDPMID:16162816
Traf7Ratpositive regulation of ubiquitin-dependent protein catabolic process involved_inISOTRAF7 (Homo sapiens)1624291 PMID:21518757RGDPMID:21518757
Traf7Ratpositive regulation of ubiquitin-dependent protein catabolic process involved_inIEAUniProtKB:Q6Q0C0 and ensembl:ENSP000003189441600115GO_REF:0000107EnsemblGO_REF:0000107
Traf7Ratprotein K29-linked ubiquitination involved_inISOTRAF7 (Homo sapiens)1624291 PMID:21518757RGDPMID:21518757
Traf7Ratprotein K29-linked ubiquitination involved_inIEAUniProtKB:Q6Q0C0 and ensembl:ENSP000003189441600115GO_REF:0000107EnsemblGO_REF:0000107
Traf7Ratprotein ubiquitination involved_inISOTRAF7 (Homo sapiens)1624291 PMID:14743216RGDPMID:14743216
Traf7Ratprotein ubiquitination involved_inIEAUniProtKB:Q6Q0C0 and ensembl:ENSP000003189441600115GO_REF:0000107EnsemblGO_REF:0000107
Traf7Ratregulation of ERK1 and ERK2 cascade involved_inISOTRAF7 (Homo sapiens)1624291 PMID:29961569RGDPMID:29961569
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Cellular Component
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Traf7Ratcytosol located_inISOTraf7 (Mus musculus)1624291 PMID:16162816RGDPMID:16162816
Traf7Ratintracellular membrane-bounded organelle located_inISOTRAF7 (Homo sapiens) and UniProtKB:Q6Q0C0-11624291 RGDGO_REF:0000052
Traf7Ratintracellular membrane-bounded organelle located_inIEAUniProtKB:Q6Q0C0 and ensembl:ENSP000003189441600115GO_REF:0000107EnsemblGO_REF:0000107
Traf7Ratnucleus is_active_inIBAPANTHER:PTN000457354 and PANTHER:PTN0085715101600115GO_REF:0000033GO_CentralGO_REF:0000033
Traf7Ratnucleus located_inISOTraf7 (Mus musculus)1624291 PMID:16162816RGDPMID:16162816
Traf7Ratperinuclear region of cytoplasm located_inISOTraf7 (Mus musculus)1624291 PMID:16162816RGDPMID:16162816
Traf7Ratplasma membrane located_inIEAUniProtKB:Q6Q0C0 and ensembl:ENSP000003189441600115GO_REF:0000107EnsemblGO_REF:0000107
Traf7Ratplasma membrane located_inISOTRAF7 (Homo sapiens) and UniProtKB:Q6Q0C0-11624291 RGDGO_REF:0000052
Traf7Ratubiquitin ligase complex part_ofISOTRAF7 (Homo sapiens)1624291 PMID:14743216RGDPMID:14743216
Traf7Ratubiquitin ligase complex part_ofIEAUniProtKB:Q6Q0C0 and ensembl:ENSP000003189441600115GO_REF:0000107EnsemblGO_REF:0000107
Traf7Ratubiquitin ligase complex part_ofIBAPANTHER:PTN008571510 and UniProtKB:Q6Q0C01600115GO_REF:0000033GO_CentralGO_REF:0000033
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Molecular Function
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Original Reference(s)
Traf7Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Traf7Ratprotein binding enablesISOTRAF7 (Homo sapiens)1624291UniProtKB:Q99759 more ...RGDPMID:14743216 more ...
Traf7Ratprotein binding enablesISOTraf7 (Mus musculus)1624291PR:P06876 PMID:16162816RGDPMID:16162816
Traf7Ratubiquitin protein ligase activity enablesISOTRAF7 (Homo sapiens)1624291 PMID:21518757RGDPMID:21518757
Traf7Ratubiquitin protein ligase activity enablesIEAUniProtKB:Q6Q0C0 and ensembl:ENSP000003189441600115GO_REF:0000107EnsemblGO_REF:0000107
Traf7Ratubiquitin-protein transferase activity enablesISOTRAF7 (Homo sapiens)1624291 PMID:14743216RGDPMID:14743216
Traf7Ratubiquitin-protein transferase activity enablesIEAUniProtKB:Q6Q0C0 and ensembl:ENSP000003189441600115GO_REF:0000107EnsemblGO_REF:0000107
Traf7Ratzinc ion binding enablesIEAUniProtKB-KW:KW-08631600115GO_REF:0000043UniProtGO_REF:0000043
Traf7Ratzinc ion binding enablesIEAInterPro:IPR0012931600115GO_REF:0000002InterProGO_REF:0000002
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. Goode B, etal., Mod Pathol. 2018 Apr;31(4):660-673. doi: 10.1038/modpathol.2017.153. Epub 2017 Nov 17.
3. TRAF7 enhances ubiquitin-degradation of KLF4 to promote hepatocellular carcinoma progression. He H, etal., Cancer Lett. 2020 Jan 28;469:380-389. doi: 10.1016/j.canlet.2019.11.012. Epub 2019 Nov 12.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42. Stevers M, etal., Mod Pathol. 2019 Jan;32(1):88-99. doi: 10.1038/s41379-018-0127-2. Epub 2018 Aug 31.
8. Up-regulation of TNF Receptor-associated Factor 7 after spinal cord injury in rats may have implication for neuronal apoptosis. Xu D, etal., Neuropeptides. 2018 Oct;71:81-89. doi: 10.1016/j.npep.2018.08.001. Epub 2018 Aug 8.
PMID:12477932   PMID:14743216   PMID:15001576   PMID:16162816   PMID:29961569  



Traf7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,038,117 - 14,056,832 (-)NCBIGRCr8
mRatBN7.21013,533,570 - 13,552,290 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,533,570 - 13,552,203 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,280,130 - 18,298,622 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,768,975 - 17,787,467 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,268,162 - 13,286,654 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,874,444 - 13,893,090 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,874,456 - 13,892,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,691,429 - 13,710,062 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,760,687 - 13,779,228 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1013,213,849 - 13,232,354 (-)NCBICelera
Cytogenetic Map10q12NCBI
TRAF7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,155,782 - 2,178,129 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,155,698 - 2,178,129 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,205,783 - 2,228,130 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,145,800 - 2,168,131 (+)NCBINCBI36Build 36hg18NCBI36
Celera162,420,218 - 2,442,550 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,132,066 - 2,154,384 (+)NCBIHuRef
CHM1_1162,205,774 - 2,228,103 (+)NCBICHM1_1
T2T-CHM13v2.0162,178,244 - 2,200,598 (+)NCBIT2T-CHM13v2.0
Traf7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,727,824 - 24,746,912 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,727,536 - 24,746,912 (-)EnsemblGRCm39 Ensembl
GRCm381724,508,850 - 24,527,938 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,508,562 - 24,527,938 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,645,795 - 24,664,883 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,236,450 - 24,255,430 (-)NCBIMGSCv36mm8
Celera1725,024,825 - 25,044,110 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.4NCBI
Traf7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,092,955 - 15,112,840 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,092,955 - 15,112,842 (-)NCBIChiLan1.0ChiLan1.0
TRAF7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,658,025 - 2,679,959 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,439,363 - 6,460,772 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,013,831 - 1,036,486 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,266,213 - 2,279,031 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,266,194 - 2,279,031 (+)Ensemblpanpan1.1panPan2
TRAF7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,788,451 - 38,805,666 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,788,454 - 38,962,167 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,027,602 - 40,044,841 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,096,963 - 39,114,204 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,096,963 - 39,114,105 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,781,803 - 38,799,041 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,754,119 - 38,771,345 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,232,866 - 39,250,103 (-)NCBIUU_Cfam_GSD_1.0
Traf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,822,976 - 104,841,154 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366941,868,309 - 1,886,772 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRAF7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,810,606 - 39,828,395 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,811,803 - 39,828,450 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,353,140 - 42,369,754 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRAF7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,051,247 - 2,072,763 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl52,059,349 - 2,071,297 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606828,989,286 - 29,010,804 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Traf7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462491379,423 - 100,279 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462491379,423 - 100,301 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Traf7
32 total Variants

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:31
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000004192
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129497586Rat

1 to 10 of 25 rows
RH130595  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,553,457 - 13,553,669 (+)MAPPERmRatBN7.2
Rnor_6.01013,894,331 - 13,894,542NCBIRnor6.0
Rnor_5.01013,711,316 - 13,711,527UniSTSRnor5.0
RGSC_v3.41013,780,562 - 13,780,773UniSTSRGSC3.4
Celera1013,233,688 - 13,233,899UniSTS
Cytogenetic Map10q12UniSTS
RH132048  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81014,057,156 - 14,057,554 (+)Marker Load Pipeline
mRatBN7.21013,552,609 - 13,553,007 (+)MAPPERmRatBN7.2
Rnor_6.01013,893,483 - 13,893,880NCBIRnor6.0
Rnor_5.01013,710,468 - 13,710,865UniSTSRnor5.0
RGSC_v3.41013,779,714 - 13,780,111UniSTSRGSC3.4
Celera1013,232,840 - 13,233,237UniSTS
RH 3.4 Map10171.7UniSTS
Cytogenetic Map10q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 23 of 23 rows
RefSeq Transcripts NM_001127548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC103090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 23 of 23 rows

Ensembl Acc Id: ENSRNOT00000004192   ⟹   ENSRNOP00000004192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,533,582 - 13,552,124 (-)Ensembl
Rnor_6.0 Ensembl1013,874,456 - 13,892,997 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097263   ⟹   ENSRNOP00000094607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,533,584 - 13,552,203 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100967   ⟹   ENSRNOP00000081332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,533,586 - 13,543,746 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107920   ⟹   ENSRNOP00000089242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,533,582 - 13,542,578 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115734   ⟹   ENSRNOP00000082217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,533,570 - 13,552,125 (-)Ensembl
RefSeq Acc Id: NM_001127548   ⟹   NP_001121020
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,038,117 - 14,056,694 (-)NCBI
mRatBN7.21013,533,570 - 13,552,147 (-)NCBI
Rnor_6.01013,874,456 - 13,892,997 (-)NCBI
Rnor_5.01013,691,429 - 13,710,062 (-)NCBI
RGSC_v3.41013,760,687 - 13,779,228 (-)RGD
Celera1013,213,849 - 13,232,354 (-)RGD
Sequence:
RefSeq Acc Id: NM_001415153   ⟹   NP_001402082
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,038,117 - 14,056,694 (-)NCBI
mRatBN7.21013,533,570 - 13,552,147 (-)NCBI
RefSeq Acc Id: XM_006245983   ⟹   XP_006246045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,038,129 - 14,056,759 (-)NCBI
mRatBN7.21013,533,570 - 13,552,219 (-)NCBI
Rnor_6.01013,874,456 - 13,893,088 (-)NCBI
Rnor_5.01013,691,429 - 13,710,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245985   ⟹   XP_006246047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,038,129 - 14,048,274 (-)NCBI
mRatBN7.21013,533,570 - 13,543,746 (-)NCBI
Rnor_6.01013,874,444 - 13,884,573 (-)NCBI
Rnor_5.01013,691,429 - 13,710,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245987   ⟹   XP_006246049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,038,129 - 14,048,274 (-)NCBI
mRatBN7.21013,533,570 - 13,543,746 (-)NCBI
Rnor_6.01013,874,444 - 13,884,573 (-)NCBI
Rnor_5.01013,691,429 - 13,710,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245991   ⟹   XP_006246053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,038,129 - 14,048,287 (-)NCBI
mRatBN7.21013,533,570 - 13,543,740 (-)NCBI
Rnor_6.01013,874,456 - 13,884,510 (-)NCBI
Rnor_5.01013,691,429 - 13,710,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245992   ⟹   XP_006246054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,038,129 - 14,048,258 (-)NCBI
mRatBN7.21013,533,570 - 13,543,706 (-)NCBI
Rnor_6.01013,874,456 - 13,884,528 (-)NCBI
Rnor_5.01013,691,429 - 13,710,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245993   ⟹   XP_006246055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,038,129 - 14,048,287 (-)NCBI
mRatBN7.21013,533,570 - 13,543,740 (-)NCBI
Rnor_6.01013,874,456 - 13,884,504 (-)NCBI
Rnor_5.01013,691,429 - 13,710,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597366   ⟹   XP_017452855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,038,129 - 14,056,760 (-)NCBI
mRatBN7.21013,533,570 - 13,552,223 (-)NCBI
Rnor_6.01013,874,456 - 13,893,088 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086269   ⟹   XP_038942197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,038,129 - 14,056,760 (-)NCBI
mRatBN7.21013,533,570 - 13,552,223 (-)NCBI
RefSeq Acc Id: XM_039086271   ⟹   XP_038942199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,038,129 - 14,056,795 (-)NCBI
mRatBN7.21013,533,570 - 13,552,290 (-)NCBI
RefSeq Acc Id: XM_063269306   ⟹   XP_063125376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,038,129 - 14,048,292 (-)NCBI
RefSeq Acc Id: XM_063269307   ⟹   XP_063125377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,038,129 - 14,048,292 (-)NCBI
RefSeq Acc Id: XM_063269308   ⟹   XP_063125378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,038,129 - 14,056,732 (-)NCBI
RefSeq Acc Id: XM_063269309   ⟹   XP_063125379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,038,129 - 14,056,832 (-)NCBI
1 to 5 of 20 rows
1 to 5 of 20 rows
RefSeq Acc Id: NP_001121020   ⟸   NM_001127548
- Peptide Label: isoform 2
- UniProtKB: B1WBW7 (UniProtKB/TrEMBL),   F7FIY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246045   ⟸   XM_006245983
- Peptide Label: isoform X1
- UniProtKB: F7FIY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246054   ⟸   XM_006245992
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AMJ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246047   ⟸   XM_006245985
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A9T1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246049   ⟸   XM_006245987
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A9T1 (UniProtKB/TrEMBL)
- Sequence:
RING-type   TRAF-type

Name Modeler Protein Id AA Range Protein Structure
AF-B1WBW7-F1-model_v2 AlphaFold B1WBW7 1-669 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697014
Promoter ID:EPDNEW_R7539
Type:initiation region
Name:Traf7_1
Description:TNF receptor associated factor 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01013,893,020 - 13,893,080EPDNEW


1 to 40 of 49 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-25853 BioCyc
Ensembl Genes ENSRNOG00000003131 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004192.5 UniProtKB/TrEMBL
  ENSRNOT00000097263 ENTREZGENE
  ENSRNOT00000097263.1 UniProtKB/TrEMBL
  ENSRNOT00000100967.1 UniProtKB/TrEMBL
  ENSRNOT00000107920.1 UniProtKB/TrEMBL
  ENSRNOT00000115734 ENTREZGENE
  ENSRNOT00000115734.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8369808 IMAGE-MGC_LOAD
InterPro G-protein_beta_WD-40_rep_reg UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
  Znf-RING_LisH UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
  Znf_TRAF UniProtKB/TrEMBL
KEGG Report rno:360491 UniProtKB/TrEMBL
MGC_CLONE MGC:187654 IMAGE-MGC_LOAD
NCBI Gene 360491 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TRAF7 UniProtKB/TrEMBL
  WD40 REPEAT PROTEIN UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
  zf-RING_UBOX UniProtKB/TrEMBL
PhenoGen Traf7 PhenoGen
PRINTS GPROTEINBRPT UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
  ZF_TRAF UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003131 RatGTEx
SMART RING UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
1 to 40 of 49 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Traf7  TNF receptor associated factor 7  Traf7  TNF receptor-associated factor 7, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Traf7  TNF receptor-associated factor 7, E3 ubiquitin protein ligase  Traf7  Tnf receptor-associated factor 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Traf7  Tnf receptor-associated factor 7   Traf7_predicted  Tnf receptor-associated factor 7 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Traf7_predicted  Tnf receptor-associated factor 7 (predicted)  RGD1559653_predicted  similar to ring finger and WD repeat domain 1 isoform 1 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1559653_predicted  similar to ring finger and WD repeat domain 1 isoform 1 (predicted)  LOC360491  similar to ring finger and WD repeat domain 1 isoform 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC360491  similar to ring finger and WD repeat domain 1 isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL