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Gene: Lats2 (large tumor suppressor kinase 2) Rattus norvegicus
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Symbol: Lats2
Name: large tumor suppressor kinase 2
Description: Predicted to have ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including hippo signaling; inner cell mass cell differentiation; and negative regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to localize to the cytosol; microtubule cytoskeleton; and nucleus. Orthologous to human LATS2 (large tumor suppressor kinase 2); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2-methoxyethanol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: large tumor suppressor 2; large tumor suppressor, homolog 2; large tumor suppressor, homolog 2 (Drosophila); LOC305922; serine/threonine-protein kinase LATS2
Orthologs:
Homo sapiens (human) : LATS2 (large tumor suppressor kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Lats2 (large tumor suppressor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lats2 (large tumor suppressor kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LATS2 (large tumor suppressor kinase 2)
Canis lupus familiaris (dog) : LATS2 (large tumor suppressor kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lats2 (large tumor suppressor kinase 2)
Sus scrofa (pig) : LATS2 (large tumor suppressor kinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01537,943,609 - 37,995,175 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01541,788,720 - 41,828,866 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41536,720,000 - 36,761,065 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11536,737,366 - 36,776,640 (-)NCBI
Celera1531,535,661 - 31,575,853 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Lats2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305906
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.