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Gene: Lats2 (large tumor suppressor kinase 2) Rattus norvegicus

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Symbol:

Lats2

Name:

large tumor suppressor kinase 2

RGD ID:

1305906

Description:

Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; hippo signaling; and regulation of signal transduction. Predicted to act upstream of or within several processes, including inner cell mass cell differentiation; keratinocyte differentiation; and negative regulation of canonical Wnt signaling pathway. Predicted to be located in centriolar satellite and cytosol. Predicted to be active in cytoplasm; nucleus; and spindle pole. Orthologous to human LATS2 (large tumor suppressor kinase 2); INTERACTS WITH 2-methoxyethanol; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

large tumor suppressor 2; large tumor suppressor, homolog 2; large tumor suppressor, homolog 2 (Drosophila); LOC305922; serine/threonine-protein kinase LATS2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LATS2 (large tumor suppressor kinase 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Lats2 (large tumor suppressor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lats2 (large tumor suppressor kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LATS2 (large tumor suppressor kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LATS2 (large tumor suppressor kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lats2 (large tumor suppressor kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LATS2 (large tumor suppressor kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LATS2 (large tumor suppressor kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lats2 (large tumor suppressor kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	LATS2 (large tumor suppressor kinase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Lats2 (large tumor suppressor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lats2 (large tumor suppressor kinase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	wts	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	wts-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	T24D5.4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	lats2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	35,940,632 - 35,992,225 (-)	NCBI		GRCr8
mRatBN7.2	15	31,825,068 - 31,877,193 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	31,825,092 - 31,877,220 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	33,816,404 - 33,856,618 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	34,967,073 - 35,007,296 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	33,225,167 - 33,265,374 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	37,943,609 - 37,995,175 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	37,943,609 - 37,983,882 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	41,788,720 - 41,828,866 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	36,720,000 - 36,761,065 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	36,737,366 - 36,776,640 (-)	NCBI
Celera	15	31,535,661 - 31,575,853 (-)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lats2	Rat	colorectal cancer	treatment	ISO	RGD:1314216	153297782	Human cells in mouse model	RGD

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lats2	Rat	peritoneal mesothelioma		ISO	RGD:1314216	8554872	ClinVar Annotator: match by term: Malignant peritoneal mesothelioma	ClinVar

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lats2	Rat	malignant astrocytoma		ISO	RGD:1314216	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:17049657

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lats2	Rat	(-)-epigallocatechin 3-gallate	multiple interactions	ISO	RGD:1314216	6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of LATS2 mRNA	CTD	PMID:22079256
Lats2	Rat	(20S)-ginsenoside Rg3	increases expression	ISO	RGD:1314216	6480464	ginsenoside Rg3 results in increased expression of LATS2 mRNA	CTD	PMID:31916386
Lats2	Rat	1,2-dimethylhydrazine	decreases expression	ISO	RGD:1314217	6480464	1,2-Dimethylhydrazine results in decreased expression of LATS2 mRNA	CTD	PMID:22206623
Lats2	Rat	17beta-estradiol	decreases expression	ISO	RGD:1314216	6480464	Estradiol results in decreased expression of LATS2 mRNA	CTD	PMID:24758408
Lats2	Rat	17beta-estradiol	decreases expression	ISO	RGD:1314217	6480464	Estradiol results in decreased expression of LATS2 mRNA	CTD	PMID:39298647
Lats2	Rat	2,2',4,4'-Tetrabromodiphenyl ether	increases expression	ISO	RGD:1314216	6480464	2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of LATS2 mRNA	CTD	PMID:19095052
Lats2	Rat	2,3',4,4',5-Pentachlorobiphenyl	increases expression	ISO	RGD:1314217	6480464	2,3',4,4',5-pentachlorobiphenyl results in increased expression of LATS2 mRNA	CTD	PMID:31388691
Lats2	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1314217	6480464	Tetrachlorodibenzodioxin affects the expression of LATS2 mRNA	CTD	PMID:21570461
Lats2	Rat	2-methoxyethanol	increases expression	EXP		6480464	methyl cellosolve results in increased expression of LATS2 mRNA	CTD	PMID:21061450
Lats2	Rat	4,4'-sulfonyldiphenol	affects expression	ISO	RGD:1314217	6480464	bisphenol S affects the expression of LATS2 mRNA	CTD	PMID:39298647
Lats2	Rat	4,4'-sulfonyldiphenol	affects methylation	ISO	RGD:1314217	6480464	bisphenol S affects the methylation of LATS2 gene	CTD	PMID:31683443
Lats2	Rat	4-hydroxyphenyl retinamide	decreases expression	ISO	RGD:1314217	6480464	Fenretinide results in decreased expression of LATS2 mRNA	CTD	PMID:28973697
Lats2	Rat	5-aza-2'-deoxycytidine	multiple interactions	ISO	RGD:1314216	6480464	[Decitabine affects the methylation of LATS2 promoter] which affects the expression of LATS2 mRNA	CTD	PMID:17049657
Lats2	Rat	5-aza-2'-deoxycytidine	affects methylation	ISO	RGD:1314216	6480464	Decitabine affects the methylation of LATS2 promoter	CTD	PMID:17049657
Lats2	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of LATS2 mRNA	CTD	PMID:24780913
Lats2	Rat	acrylamide	increases expression	ISO	RGD:1314216	6480464	Acrylamide results in increased expression of LATS2 mRNA	CTD	PMID:32763439
Lats2	Rat	aflatoxin B1	increases expression	ISO	RGD:1314217	6480464	Aflatoxin B1 results in increased expression of LATS2 mRNA	CTD	PMID:19770486
Lats2	Rat	aflatoxin B1	decreases methylation	ISO	RGD:1314216	6480464	Aflatoxin B1 results in decreased methylation of LATS2 intron	CTD	PMID:30157460
Lats2	Rat	Aflatoxin B2 alpha	increases methylation	ISO	RGD:1314216	6480464	aflatoxin B2 results in increased methylation of LATS2 intron	CTD	PMID:30157460
Lats2	Rat	antirheumatic drug	increases expression	ISO	RGD:1314216	6480464	Antirheumatic Agents results in increased expression of LATS2 mRNA	CTD	PMID:24449571
Lats2	Rat	arsenite(3-)	multiple interactions	ISO	RGD:1314216	6480464	arsenite inhibits the reaction [G3BP1 protein binds to LATS2 mRNA]	CTD	PMID:32406909
Lats2	Rat	arsenous acid	increases expression	ISO	RGD:1314216	6480464	Arsenic Trioxide results in increased expression of LATS2 mRNA	CTD	PMID:20458559
Lats2	Rat	atrazine	decreases expression	ISO	RGD:1314217	6480464	Atrazine results in decreased expression of LATS2 mRNA	CTD	PMID:33463082
Lats2	Rat	benzo[a]pyrene	multiple interactions	ISO	RGD:1314217	6480464	Benzo(a)pyrene promotes the reaction [AHR protein binds to LATS2 promoter]	CTD	PMID:19654925
Lats2	Rat	benzo[a]pyrene	affects methylation	ISO	RGD:1314216	6480464	Benzo(a)pyrene affects the methylation of LATS2 intron	CTD	PMID:30157460
Lats2	Rat	benzo[a]pyrene diol epoxide I	decreases expression	ISO	RGD:1314216	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LATS2 mRNA	CTD	PMID:19150397\|PMID:20018196
Lats2	Rat	bis(2-ethylhexyl) phthalate	multiple interactions	ISO	RGD:1314217	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Lats2	Rat	bisphenol A	affects expression	ISO	RGD:1314216	6480464	bisphenol A affects the expression of LATS2 mRNA	CTD	PMID:20170705
Lats2	Rat	bisphenol A	increases expression	ISO	RGD:1314217	6480464	bisphenol A results in increased expression of LATS2 mRNA	CTD	PMID:32156529
Lats2	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of LATS2 mRNA	CTD	PMID:30816183\|PMID:32528016\|PMID:34947998
Lats2	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of LATS2 gene	CTD	PMID:28505145
Lats2	Rat	bisphenol A	affects expression	EXP		6480464	bisphenol A affects the expression of LATS2 mRNA	CTD	PMID:25181051
Lats2	Rat	bisphenol F	increases expression	ISO	RGD:1314217	6480464	bisphenol F results in increased expression of LATS2 mRNA	CTD	PMID:30951980
Lats2	Rat	Butylbenzyl phthalate	multiple interactions	ISO	RGD:1314217	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Lats2	Rat	C60 fullerene	decreases expression	EXP		6480464	fullerene C60 results in decreased expression of LATS2 mRNA	CTD	PMID:19167457
Lats2	Rat	cadmium dichloride	increases expression	ISO	RGD:1314216	6480464	Cadmium Chloride results in increased expression of LATS2 mRNA	CTD	PMID:38568856
Lats2	Rat	caffeine	decreases phosphorylation	ISO	RGD:1314216	6480464	Caffeine results in decreased phosphorylation of LATS2 protein	CTD	PMID:35688186
Lats2	Rat	carbamazepine	affects expression	ISO	RGD:1314216	6480464	Carbamazepine affects the expression of LATS2 mRNA	CTD	PMID:25979313
Lats2	Rat	carbon nanotube	decreases expression	ISO	RGD:1314217	6480464	Nanotubes, Carbon analog results in decreased expression of LATS2 mRNA	CTD	PMID:25554681
Lats2	Rat	choline	multiple interactions	ISO	RGD:1314217	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ...	CTD	PMID:20938992
Lats2	Rat	cisplatin	decreases expression	ISO	RGD:1314216	6480464	Cisplatin results in decreased expression of LATS2 mRNA	CTD	PMID:27392435
Lats2	Rat	cisplatin	multiple interactions	ISO	RGD:1314216	6480464	[Cisplatin co-treated with jinfukang] results in decreased expression of LATS2 mRNA	CTD	PMID:27392435
Lats2	Rat	copper atom	multiple interactions	ISO	RGD:1314216	6480464	[NSC 689534 binds to Copper] which results in increased expression of LATS2 mRNA	CTD	PMID:20971185
Lats2	Rat	copper atom	affects binding	ISO	RGD:1314216	6480464	Copper binds to LATS2 protein	CTD	PMID:35027733
Lats2	Rat	copper atom	decreases expression	ISO	RGD:1314216	6480464	Copper results in decreased expression of LATS2 protein	CTD	PMID:16246896
Lats2	Rat	copper(0)	multiple interactions	ISO	RGD:1314216	6480464	[NSC 689534 binds to Copper] which results in increased expression of LATS2 mRNA	CTD	PMID:20971185
Lats2	Rat	copper(0)	affects binding	ISO	RGD:1314216	6480464	Copper binds to LATS2 protein	CTD	PMID:35027733
Lats2	Rat	copper(0)	decreases expression	ISO	RGD:1314216	6480464	Copper results in decreased expression of LATS2 protein	CTD	PMID:16246896
Lats2	Rat	copper(II) sulfate	increases expression	ISO	RGD:1314216	6480464	Copper Sulfate results in increased expression of LATS2 mRNA	CTD	PMID:19549813
Lats2	Rat	coumarin	decreases phosphorylation	ISO	RGD:1314216	6480464	coumarin results in decreased phosphorylation of LATS2 protein	CTD	PMID:35688186
Lats2	Rat	crocidolite asbestos	increases expression	ISO	RGD:1314216	6480464	Asbestos, Crocidolite results in increased expression of LATS2 mRNA	CTD	PMID:18687144
Lats2	Rat	crocidolite asbestos	decreases expression	ISO	RGD:1314217	6480464	Asbestos, Crocidolite results in decreased expression of LATS2 mRNA	CTD	PMID:29279043
Lats2	Rat	CU-O LINKAGE	increases expression	ISO	RGD:1314216	6480464	cupric oxide results in increased expression of LATS2 mRNA	CTD	PMID:22077320
Lats2	Rat	cyclosporin A	decreases expression	ISO	RGD:1314217	6480464	Cyclosporine results in decreased expression of LATS2 mRNA	CTD	PMID:19770486
Lats2	Rat	cyclosporin A	decreases expression	ISO	RGD:1314216	6480464	Cyclosporine results in decreased expression of LATS2 mRNA	CTD	PMID:25562108
Lats2	Rat	diarsenic trioxide	increases expression	ISO	RGD:1314216	6480464	Arsenic Trioxide results in increased expression of LATS2 mRNA	CTD	PMID:20458559
Lats2	Rat	diazinon	affects expression	EXP		6480464	Diazinon affects the expression of LATS2 mRNA	CTD	PMID:22546817
Lats2	Rat	Dibutyl phosphate	affects expression	ISO	RGD:1314216	6480464	di-n-butylphosphoric acid affects the expression of LATS2 mRNA	CTD	PMID:37042841
Lats2	Rat	dibutyl phthalate	increases expression	ISO	RGD:1314217	6480464	Dibutyl Phthalate results in increased expression of LATS2 mRNA	CTD	PMID:17361019\|PMID:21266533
Lats2	Rat	dibutyl phthalate	multiple interactions	ISO	RGD:1314217	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Lats2	Rat	diethyl phthalate	multiple interactions	ISO	RGD:1314217	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Lats2	Rat	diisobutyl phthalate	multiple interactions	ISO	RGD:1314217	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Lats2	Rat	diisononyl phthalate	multiple interactions	ISO	RGD:1314217	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Lats2	Rat	diuron	decreases expression	EXP		6480464	Diuron results in decreased expression of LATS2 mRNA	CTD	PMID:25152437
Lats2	Rat	dorsomorphin	multiple interactions	ISO	RGD:1314216	6480464	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Lats2	Rat	doxorubicin	increases expression	ISO	RGD:1314216	6480464	Doxorubicin results in increased expression of LATS2 mRNA	CTD	PMID:29803840
Lats2	Rat	epoxiconazole	decreases expression	ISO	RGD:1314217	6480464	epoxiconazole results in decreased expression of LATS2 mRNA	CTD	PMID:35436446
Lats2	Rat	ethyl methanesulfonate	increases expression	ISO	RGD:1314216	6480464	Ethyl Methanesulfonate results in increased expression of LATS2 mRNA	CTD	PMID:23649840
Lats2	Rat	fenamidone	increases expression	ISO	RGD:1314217	6480464	fenamidone results in increased expression of LATS2 mRNA	CTD	PMID:27029645
Lats2	Rat	fisetin	increases phosphorylation	ISO	RGD:1314216	6480464	fisetin results in increased phosphorylation of LATS2 protein	CTD	PMID:31044527
Lats2	Rat	folic acid	multiple interactions	ISO	RGD:1314217	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ...	CTD	PMID:20938992
Lats2	Rat	folic acid	decreases expression	ISO	RGD:1314217	6480464	Folic Acid results in decreased expression of LATS2 mRNA	CTD	PMID:25629700
Lats2	Rat	formaldehyde	increases expression	ISO	RGD:1314216	6480464	Formaldehyde results in increased expression of LATS2 mRNA	CTD	PMID:23649840
Lats2	Rat	hydrogen cyanide	decreases expression	ISO	RGD:1314217	6480464	Hydrogen Cyanide results in decreased expression of LATS2 mRNA	CTD	PMID:33914522
Lats2	Rat	hydrogen peroxide	affects expression	ISO	RGD:1314216	6480464	Hydrogen Peroxide affects the expression of LATS2 mRNA	CTD	PMID:20044591
Lats2	Rat	iron dichloride	increases expression	ISO	RGD:1314216	6480464	ferrous chloride results in increased expression of LATS2 mRNA	CTD	PMID:35984750
Lats2	Rat	L-methionine	multiple interactions	ISO	RGD:1314217	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ...	CTD	PMID:20938992
Lats2	Rat	menadione	affects expression	ISO	RGD:1314216	6480464	Vitamin K 3 affects the expression of LATS2 mRNA	CTD	PMID:20044591
Lats2	Rat	methoxychlor	affects methylation	EXP		6480464	Methoxychlor affects the methylation of LATS2 gene	CTD	PMID:35440735
Lats2	Rat	methyl methanesulfonate	increases expression	ISO	RGD:1314216	6480464	Methyl Methanesulfonate results in increased expression of LATS2 mRNA	CTD	PMID:23649840
Lats2	Rat	methylmercury chloride	increases expression	ISO	RGD:1314216	6480464	methylmercuric chloride results in increased expression of LATS2 mRNA	CTD	PMID:28001369
Lats2	Rat	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	multiple interactions	ISO	RGD:1314216	6480464	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc binds to LATS2 protein]; TP53 mutant form inhibits the reaction more ...	CTD	PMID:18778698\|PMID:35027733
Lats2	Rat	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	decreases expression	ISO	RGD:1314216	6480464	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of LATS2 mRNA	CTD	PMID:18778698
Lats2	Rat	nitrates	multiple interactions	ISO	RGD:1314217	6480464	[Particulate Matter results in increased abundance of Nitrates] which results in increased expression of LATS2 more ...	CTD	PMID:35964746
Lats2	Rat	oxaliplatin	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in increased expression of LATS2 mRNA	CTD	PMID:25729387
Lats2	Rat	oxaliplatin	increases expression	EXP		6480464	oxaliplatin results in increased expression of LATS2 mRNA	CTD	PMID:25729387
Lats2	Rat	ozone	multiple interactions	ISO	RGD:1314217	6480464	[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ...	CTD	PMID:34911549
Lats2	Rat	paracetamol	affects expression	ISO	RGD:1314217	6480464	Acetaminophen affects the expression of LATS2 mRNA	CTD	PMID:17562736
Lats2	Rat	perfluorobutanesulfonic acid	multiple interactions	ISO	RGD:1314217	6480464	[perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate co-treated with perfluorobutanesulfonic acid] more ...	CTD	PMID:39141488
Lats2	Rat	perfluorononanoic acid	decreases expression	ISO	RGD:1314216	6480464	perfluoro-n-nonanoic acid results in decreased expression of LATS2 mRNA	CTD	PMID:38568856
Lats2	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	RGD:1314217	6480464	[perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate co-treated with perfluorobutanesulfonic acid] more ...	CTD	PMID:39141488
Lats2	Rat	perfluorooctanoic acid	multiple interactions	ISO	RGD:1314217	6480464	[perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate co-treated with perfluorobutanesulfonic acid] more ...	CTD	PMID:39141488
Lats2	Rat	phenobarbital	affects expression	ISO	RGD:1314217	6480464	Phenobarbital affects the expression of LATS2 mRNA	CTD	PMID:23091169
Lats2	Rat	potassium chloride	multiple interactions	ISO	RGD:1314216	6480464	[Dronabinol results in decreased susceptibility to Potassium Chloride] which results in increased expression of LATS2 more ...	CTD	PMID:29691375
Lats2	Rat	potassium chromate	multiple interactions	ISO	RGD:1314216	6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of LATS2 mRNA	CTD	PMID:22079256
Lats2	Rat	potassium chromate	increases expression	ISO	RGD:1314216	6480464	potassium chromate(VI) results in increased expression of LATS2 mRNA	CTD	PMID:22079256
Lats2	Rat	potassium cyanide	decreases expression	ISO	RGD:1314217	6480464	Potassium Cyanide results in decreased expression of LATS2 mRNA	CTD	PMID:33914522
Lats2	Rat	SB 431542	multiple interactions	ISO	RGD:1314216	6480464	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Lats2	Rat	silver atom	increases expression	ISO	RGD:1314216	6480464	Silver results in increased expression of LATS2 mRNA	CTD	PMID:26014281
Lats2	Rat	silver(0)	increases expression	ISO	RGD:1314216	6480464	Silver results in increased expression of LATS2 mRNA	CTD	PMID:26014281
Lats2	Rat	sodium arsenite	increases expression	ISO	RGD:1314216	6480464	sodium arsenite results in increased expression of LATS2 mRNA	CTD	PMID:38568856
Lats2	Rat	tetrachloromethane	affects expression	ISO	RGD:1314217	6480464	Carbon Tetrachloride affects the expression of LATS2 mRNA	CTD	PMID:17484886
Lats2	Rat	thalidomide	increases expression	ISO	RGD:1314216	6480464	Thalidomide analog results in increased expression of LATS2 mRNA	CTD	PMID:20525221
Lats2	Rat	thiram	increases expression	ISO	RGD:1314216	6480464	Thiram results in increased expression of LATS2 mRNA	CTD	PMID:38568856
Lats2	Rat	titanium dioxide	decreases expression	ISO	RGD:1314217	6480464	titanium dioxide results in decreased expression of LATS2 mRNA	CTD	PMID:23557971
Lats2	Rat	titanium dioxide	decreases methylation	ISO	RGD:1314217	6480464	titanium dioxide results in decreased methylation of LATS2 gene	CTD	PMID:35295148
Lats2	Rat	titanium dioxide	increases methylation	ISO	RGD:1314217	6480464	titanium dioxide results in increased methylation of LATS2 gene	CTD	PMID:35295148
Lats2	Rat	topotecan	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in increased expression of LATS2 mRNA	CTD	PMID:25729387
Lats2	Rat	topotecan	increases expression	EXP		6480464	Topotecan results in increased expression of LATS2 mRNA	CTD	PMID:25729387
Lats2	Rat	trichostatin A	decreases expression	ISO	RGD:1314216	6480464	trichostatin A results in decreased expression of LATS2 mRNA	CTD	PMID:26272509
Lats2	Rat	trichostatin A	multiple interactions	ISO	RGD:1314216	6480464	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Lats2	Rat	triptonide	affects expression	ISO	RGD:1314217	6480464	triptonide affects the expression of LATS2 mRNA	CTD	PMID:33045310
Lats2	Rat	troglitazone	increases expression	ISO	RGD:1314217	6480464	troglitazone results in increased expression of LATS2 mRNA	CTD	PMID:28973697
Lats2	Rat	tungsten	decreases expression	ISO	RGD:1314217	6480464	Tungsten results in decreased expression of LATS2 mRNA	CTD	PMID:30912803
Lats2	Rat	urethane	increases expression	ISO	RGD:1314216	6480464	Urethane results in increased expression of LATS2 mRNA	CTD	PMID:28818685
Lats2	Rat	valproic acid	decreases expression	ISO	RGD:1314216	6480464	Valproic Acid results in decreased expression of LATS2 mRNA	CTD	PMID:23179753
Lats2	Rat	valproic acid	affects expression	ISO	RGD:1314216	6480464	Valproic Acid affects the expression of LATS2 mRNA	CTD	PMID:25979313
Lats2	Rat	vinclozolin	decreases expression	ISO	RGD:1314217	6480464	vinclozolin results in decreased expression of LATS2 mRNA	CTD	PMID:34182078
Lats2	Rat	vinclozolin	increases expression	ISO	RGD:1314217	6480464	vinclozolin results in increased expression of LATS2 mRNA	CTD	PMID:36642194
Lats2	Rat	zinc atom	multiple interactions	ISO	RGD:1314216	6480464	[PCI 5002 co-treated with Zinc] results in increased expression of LATS2 mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the more ...	CTD	PMID:18593933\|PMID:35027733
Lats2	Rat	zinc atom	affects binding	ISO	RGD:1314216	6480464	Zinc binds to LATS2 protein	CTD	PMID:35027733
Lats2	Rat	zinc(0)	multiple interactions	ISO	RGD:1314216	6480464	[PCI 5002 co-treated with Zinc] results in increased expression of LATS2 mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the more ...	CTD	PMID:18593933\|PMID:35027733
Lats2	Rat	zinc(0)	affects binding	ISO	RGD:1314216	6480464	Zinc binds to LATS2 protein	CTD	PMID:35027733

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lats2	Rat	canonical Wnt signaling pathway	acts_upstream_of	ISO	RGD:1314217	1624291	MGI:88276 PMID:21512031	RGD	PMID:21512031
Lats2	Rat	canonical Wnt signaling pathway	acts_upstream_of	IEA	UniProtKB:Q7TSJ6\|ensembl:ENSMUSP00000022531	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	G1/S transition of mitotic cell cycle	involved_in	ISO	RGD:1314217	1624291	PMID:15343267	RGD	PMID:15343267
Lats2	Rat	G1/S transition of mitotic cell cycle	involved_in	IEA	UniProtKB:Q7TSJ6\|ensembl:ENSMUSP00000022531	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	G1/S transition of mitotic cell cycle	involved_in	IBA	MGI:1354386\|PANTHER:PTN002390470\|UniProtKB:Q9NRM7	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Lats2	Rat	G1/S transition of mitotic cell cycle	involved_in	IEA	UniProtKB:Q9NRM7\|ensembl:ENSP00000372035	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	G1/S transition of mitotic cell cycle	involved_in	ISO	RGD:1314216	1624291	PMID:12853976	RGD	PMID:12853976
Lats2	Rat	hippo signaling	involved_in	ISO	RGD:1314216	1624291	PMID:20412773, PMID:35429439	RGD	PMID:20412773\|PMID:35429439
Lats2	Rat	hippo signaling	acts_upstream_of_or_within	ISO	RGD:1314217	1624291	MGI:103262\|MGI:1927144\|MGI:1929004 PMID:18369314	RGD	PMID:18369314
Lats2	Rat	hippo signaling	involved_in	IEA	UniProtKB:Q9NRM7\|ensembl:ENSP00000372035	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	hippo signaling	involved_in	IBA	FB:FBgn0011739\|MGI:1333883\|MGI:1354386\|PANTHER:PTN002390470\|UniProtKB:O95835\|UniProtKB:Q9NRM7	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Lats2	Rat	hippo signaling	acts_upstream_of_or_within	IEA	UniProtKB:Q7TSJ6\|ensembl:ENSMUSP00000022531	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	hormone-mediated signaling pathway	involved_in	ISO	RGD:1314216	1624291	PMID:15131260	RGD	PMID:15131260
Lats2	Rat	hormone-mediated signaling pathway	involved_in	IEA	UniProtKB:Q9NRM7\|ensembl:ENSP00000372035	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	inner cell mass cell fate commitment	acts_upstream_of_or_within	ISO	RGD:1314217	1624291	MGI:1333883 PMID:23824537	RGD	PMID:23824537
Lats2	Rat	inner cell mass cell fate commitment	acts_upstream_of_or_within	IEA	UniProtKB:Q7TSJ6\|ensembl:ENSMUSP00000022531	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	inner cell mass cellular morphogenesis	acts_upstream_of_or_within	ISO	RGD:1314217	1624291	MGI:1333883 PMID:23824537	RGD	PMID:23824537
Lats2	Rat	inner cell mass cellular morphogenesis	acts_upstream_of_or_within	IEA	UniProtKB:Q7TSJ6\|ensembl:ENSMUSP00000022531	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	intracellular signal transduction	involved_in	ISO	RGD:1314216	1624291	PMID:10871863	RGD	PMID:10871863
Lats2	Rat	intracellular signal transduction	involved_in	IEA	UniProtKB:Q9NRM7\|ensembl:ENSP00000372035	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	keratinocyte differentiation	acts_upstream_of_or_within	ISO	RGD:1314217	1624291	MGI:103262\|MGI:1927144\|MGI:1929004 PMID:18369314	RGD	PMID:18369314
Lats2	Rat	keratinocyte differentiation	acts_upstream_of_or_within	IEA	UniProtKB:Q7TSJ6\|ensembl:ENSMUSP00000022531	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	negative regulation of canonical Wnt signaling pathway	involved_in	ISO	RGD:1314216	1624291	PMID:20412773	RGD	PMID:20412773
Lats2	Rat	negative regulation of canonical Wnt signaling pathway	acts_upstream_of_or_within	IEA	UniProtKB:Q7TSJ6\|ensembl:ENSMUSP00000022531	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	negative regulation of canonical Wnt signaling pathway	acts_upstream_of_or_within	ISO	RGD:1314217	1624291	MGI:88276 PMID:21512031	RGD	PMID:21512031
Lats2	Rat	negative regulation of canonical Wnt signaling pathway	involved_in	IEA	UniProtKB:Q9NRM7\|ensembl:ENSP00000372035	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	negative regulation of cyclin-dependent protein serine/threonine kinase activity	involved_in	ISO	RGD:1314216	1624291	PMID:12853976	RGD	PMID:12853976
Lats2	Rat	negative regulation of protein localization to nucleus	involved_in	ISO	RGD:1314217	1624291	PMID:21145499	RGD	PMID:21145499
Lats2	Rat	negative regulation of protein localization to nucleus	involved_in	IEA	UniProtKB:Q7TSJ6\|ensembl:ENSMUSP00000022531	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	positive regulation of apoptotic process	involved_in	IBA	FB:FBgn0011739\|PANTHER:PTN002390470	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Lats2	Rat	positive regulation of NLRP3 inflammasome complex assembly	involved_in	ISO	RGD:1314217	1624291	PMID:39173637	RGD	PMID:39173637
Lats2	Rat	positive regulation of NLRP3 inflammasome complex assembly	involved_in	IEA	UniProtKB:Q7TSJ6\|ensembl:ENSMUSP00000022531	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	positive regulation of NLRP3 inflammasome complex assembly	involved_in	IEA	UniProtKB:Q9NRM7\|ensembl:ENSP00000372035	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	positive regulation of NLRP3 inflammasome complex assembly	involved_in	ISO	RGD:1314216	1624291	PMID:39173637	RGD	PMID:39173637
Lats2	Rat	protein localization	acts_upstream_of_or_within	IEA	UniProtKB:Q7TSJ6\|ensembl:ENSMUSP00000022531	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	protein localization	acts_upstream_of_or_within	ISO	RGD:1314217	1624291	MGI:1333883 PMID:19289085	RGD	PMID:19289085
Lats2	Rat	protein phosphorylation	acts_upstream_of_or_within	ISO	RGD:1314217	1624291	PMID:19289085	RGD	PMID:19289085
Lats2	Rat	protein phosphorylation	involved_in	ISO	RGD:1314216	1624291	PMID:10871863	RGD	PMID:10871863
Lats2	Rat	regulation of organ growth	involved_in	IBA	MGI:1354386\|PANTHER:PTN002390470	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Lats2	Rat	regulation of organ growth	acts_upstream_of_or_within	IEA	UniProtKB:Q7TSJ6\|ensembl:ENSMUSP00000022531	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	regulation of organ growth	acts_upstream_of_or_within	ISO	RGD:1314217	1624291	MGI:2654594\|MGI:4430538 PMID:21512031	RGD	PMID:21512031
Lats2	Rat	regulation of transforming growth factor beta receptor signaling pathway	involved_in	ISO	RGD:1314217	1624291	PMID:21145499	RGD	PMID:21145499
Lats2	Rat	regulation of transforming growth factor beta receptor signaling pathway	involved_in	IEA	UniProtKB:Q7TSJ6\|ensembl:ENSMUSP00000022531	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lats2	Rat	centriolar satellite	located_in	ISO	RGD:1314216	1624291		RGD	GO_REF:0000052
Lats2	Rat	centriolar satellite	located_in	IEA	UniProtKB:Q9NRM7\|ensembl:ENSP00000372035	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	cytoplasm	is_active_in	ISO	RGD:1314216	1624291	PMID:35429439	RGD	PMID:35429439
Lats2	Rat	cytoplasm	is_active_in	IEA	UniProtKB:Q9NRM7\|ensembl:ENSP00000372035	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	cytosol	located_in	IEA	UniProtKB:Q9NRM7\|ensembl:ENSP00000372035	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	cytosol	located_in	ISO	RGD:1314216	1624291	PMID:30865227	RGD	GO_REF:0000052\|PMID:30865227
Lats2	Rat	microtubule cytoskeleton	located_in	IEA	ARBA:ARBA00029268	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Lats2	Rat	nucleus	located_in	ISO	RGD:1314216	1624291	PMID:10673337	RGD	PMID:10673337
Lats2	Rat	nucleus	located_in	IEA	UniProtKB:Q9NRM7\|ensembl:ENSP00000372035	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	nucleus	is_active_in	IBA	PANTHER:PTN004697711\|UniProtKB:Q9NRM7	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Lats2	Rat	spindle pole	located_in	ISO	RGD:1314217	1624291	PMID:15343267	RGD	PMID:15343267
Lats2	Rat	spindle pole	located_in	IEA	UniProtKB:Q7TSJ6\|ensembl:ENSMUSP00000022531	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	spindle pole	located_in	IEA	UniProtKB:Q9NRM7\|ensembl:ENSP00000372035	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	spindle pole	is_active_in	IBA	MGI:1354386\|PANTHER:PTN004697711\|UniProtKB:Q9NRM7	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Lats2	Rat	spindle pole	located_in	ISO	RGD:1314216	1624291	PMID:12853976	RGD	PMID:12853976

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lats2	Rat	ATP binding	enables	ISO	RGD:1314216	1624291	PMID:10871863	RGD	PMID:10871863
Lats2	Rat	ATP binding	enables	IEA	InterPro:IPR000719\|InterPro:IPR000961\|InterPro:IPR017441\|InterPro:IPR017892	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Lats2	Rat	ATP binding	enables	IEA	UniProtKB-KW:KW-0067	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Lats2	Rat	ATP binding	enables	IEA	UniRule:UR001503341	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Lats2	Rat	ATP binding	enables	IEA	UniProtKB:Q9NRM7\|ensembl:ENSP00000372035	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	kinase activity	enables	IEA	UniProtKB-KW:KW-0418	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Lats2	Rat	nucleotide binding	enables	IEA	UniProtKB-KW:KW-0547	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Lats2	Rat	nucleotide binding	enables	IEA	UniRule:UR001503341	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Lats2	Rat	protein binding	enables	ISO	RGD:1314216	1624291	UniProtKB:A6NIX2\|UniProtKB:O14578\|UniProtKB:O43255\|UniProtKB:P46937\|UniProtKB:Q13643\|UniProtKB:Q6AWC2\|UniProtKB:Q7L9L4\|UniProtKB:Q8IX03\|UniProtKB:Q96IF1\|UniProtKB:Q9H8S9\|UniProtKB:Q9UGP4\|UniProtKB:Q9ULE0\|UniProtKB:Q9Y4B6 PMID:16413547, PMID:18158288, PMID:19739119, PMID:20303269, PMID:24255178, PMID:24682284, PMID:25026211, PMID:25438054, PMID:27107012, PMID:28514442, PMID:30865227, PMID:32707033, PMID:33961781	RGD	PMID:16413547\|PMID:18158288\|PMID:19739119\|PMID:20303269\|PMID:24255178\|PMID:24682284\|PMID:25026211\|PMID:25438054\|PMID:27107012\|PMID:28514442\|PMID:30865227\|PMID:32707033\|PMID:33961781
Lats2	Rat	protein kinase activity	enables	IEA	InterPro:IPR000719\|InterPro:IPR008271	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Lats2	Rat	protein serine/threonine kinase activity	enables	ISO	RGD:1314217	1624291	PMID:39173637	RGD	PMID:39173637
Lats2	Rat	protein serine/threonine kinase activity	enables	IEA	UniProtKB:Q9NRM7\|ensembl:ENSP00000372035	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	protein serine/threonine kinase activity	enables	IEA	UniProtKB:Q7TSJ6\|ensembl:ENSMUSP00000022531	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Lats2	Rat	protein serine/threonine kinase activity	enables	IEA	UniProtKB-KW:KW-0723	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Lats2	Rat	protein serine/threonine kinase activity	enables	IEA	InterPro:IPR000961\|InterPro:IPR017892	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Lats2	Rat	protein serine/threonine kinase activity	enables	IBA	CGD:CAL0000179865\|CGD:CAL0000201435\|FB:FBgn0003091\|FB:FBgn0003744\|FB:FBgn0011739\|FB:FBgn0020386\|FB:FBgn0260399\|FB:FBgn0287828\|MGI:104874\|MGI:1338068\|MGI:1345147\|MGI:1354386\|MGI:87986\|MGI:894676\|MGI:97596\|MGI:97598\|MGI:97599\|MGI:97602\|MGI:99260\|PANTHER:PTN000683254\|PomBase:SPAC1B9.02c\|PomBase:SPAC22E12.14c\|PomBase:SPAC24B11.11c\|PomBase:SPAC821.12\|PomBase:SPAPB18E9.02c\|RGD:2081\|RGD:2082\|RGD:3399\|RGD:3668\|RGD:61925\|RGD:620146\|RGD:620307\|RGD:621888\|RGD:67383\|SGD:S000001248\|SGD:S000001861\|SGD:S000002898\|SGD:S000003324\|SGD:S000006315\|TAIR:locus:2024167\|TAIR:locus:2090925\|TAIR:locus:2178208\|TAIR:locus:2184357\|UniProtKB:A0A8J1KX42\|UniProtKB:O95835\|UniProtKB:P04409\|UniProtKB:P05129\|UniProtKB:P31751\|UniProtKB:P41743\|UniProtKB:Q05513\|UniProtKB:Q05655\|UniProtKB:Q09013\|UniProtKB:Q15208\|UniProtKB:Q16512\|UniProtKB:Q16513\|UniProtKB:Q5A3P6\|UniProtKB:Q96GX5\|UniProtKB:Q9Y243\|UniProtKB:Q9Y2H1\|WB:WBGene00004032\|WB:WBGene00004033\|WB:WBGene00004034\|dictyBase:DDB_G0268620	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Lats2	Rat	protein serine/threonine kinase activity	enables	ISO	RGD:1314216	1624291	PMID:10871863, PMID:30865227, PMID:35429439, PMID:39173637	RGD	PMID:10871863\|PMID:30865227\|PMID:35429439\|PMID:39173637
Lats2	Rat	transferase activity	enables	IEA	UniProtKB-KW:KW-0808	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

Disease Annotations Click to see Annotation Detail View

colorectal cancer (ISO)

malignant astrocytoma (ISO)

peritoneal mesothelioma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(20S)-ginsenoside Rg3 (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-methoxyethanol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

C60 fullerene (EXP)

cadmium dichloride (ISO)

caffeine (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

choline (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

crocidolite asbestos (ISO)

CU-O LINKAGE (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

diazinon (EXP)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

diethyl phthalate (ISO)

diisobutyl phthalate (ISO)

diisononyl phthalate (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

fenamidone (ISO)

fisetin (ISO)

folic acid (ISO)

formaldehyde (ISO)

hydrogen cyanide (ISO)

hydrogen peroxide (ISO)

iron dichloride (ISO)

L-methionine (ISO)

menadione (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (ISO)

nitrates (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (ISO)

perfluorobutanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

potassium chloride (ISO)

potassium chromate (ISO)

potassium cyanide (ISO)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

tetrachloromethane (ISO)

thalidomide (ISO)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichostatin A (ISO)

triptonide (ISO)

troglitazone (ISO)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

canonical Wnt signaling pathway (IEA,ISO)

G1/S transition of mitotic cell cycle (IBA,IEA,ISO)

hippo signaling (IBA,IEA,ISO)

hormone-mediated signaling pathway (IEA,ISO)

inner cell mass cell fate commitment (IEA,ISO)

inner cell mass cellular morphogenesis (IEA,ISO)

intracellular signal transduction (IEA,ISO)

keratinocyte differentiation (IEA,ISO)

negative regulation of canonical Wnt signaling pathway (IEA,ISO)

negative regulation of cyclin-dependent protein serine/threonine kinase activity (ISO)

negative regulation of protein localization to nucleus (IEA,ISO)

positive regulation of apoptotic process (IBA)

positive regulation of NLRP3 inflammasome complex assembly (IEA,ISO)

protein localization (IEA,ISO)

protein phosphorylation (ISO)

regulation of organ growth (IBA,IEA,ISO)

regulation of transforming growth factor beta receptor signaling pathway (IEA,ISO)

Cellular Component

centriolar satellite (IEA,ISO)

cytoplasm (IEA,ISO)

cytosol (IEA,ISO)

microtubule cytoskeleton (IEA)

nucleus (IBA,IEA,ISO)

spindle pole (IBA,IEA,ISO)

Molecular Function

ATP binding (IEA,ISO)

kinase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IEA,ISO)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	LINC00689 participates in proliferation, chemoresistance and metastasis via miR-31-5p/YAP/β-catenin axis in colorectal cancer.	Du YL, etal., Exp Cell Res. 2020 Oct 1;395(1):112176. doi: 10.1016/j.yexcr.2020.112176. Epub 2020 Jul 16.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10673337	PMID:10871863	PMID:12853976	PMID:15131260	PMID:15343267	PMID:18369314	PMID:19289085	PMID:20412773	PMID:21512031	PMID:22020941	PMID:23824537	PMID:31829064
PMID:32054526	PMID:32375631

Genomics

Comparative Map Data

Lats2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	35,940,632 - 35,992,225 (-)	NCBI		GRCr8
mRatBN7.2	15	31,825,068 - 31,877,193 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	31,825,092 - 31,877,220 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	33,816,404 - 33,856,618 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	34,967,073 - 35,007,296 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	33,225,167 - 33,265,374 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	37,943,609 - 37,995,175 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	37,943,609 - 37,983,882 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	41,788,720 - 41,828,866 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	36,720,000 - 36,761,065 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	36,737,366 - 36,776,640 (-)	NCBI
Celera	15	31,535,661 - 31,575,853 (-)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

LATS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	20,973,036 - 21,061,586 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	20,973,036 - 21,061,586 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	21,547,175 - 21,635,725 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	20,445,175 - 20,533,722 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	13	20,446,578 - 20,533,654	NCBI
Celera	13	2,609,110 - 2,697,695 (-)	NCBI		Celera
Cytogenetic Map	13	q12.11	NCBI
HuRef	13	2,350,083 - 2,438,773 (-)	NCBI		HuRef
CHM1_1	13	21,515,524 - 21,603,910 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	13	20,166,164 - 20,254,674 (-)	NCBI		T2T-CHM13v2.0

Lats2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	57,927,119 - 57,983,669 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	57,879,534 - 57,983,560 (-)	Ensembl		GRCm39 Ensembl
GRCm39 Ensembl	14	57,927,119 - 57,995,845 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	57,689,662 - 57,746,212 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	57,642,077 - 57,746,103 (-)	Ensembl	GRCm38		mm10	GRCm38
GRCm38.p6 Ensembl	14	57,689,662 - 57,758,388 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	58,308,499 - 58,364,960 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	56,643,772 - 56,700,233 (-)	NCBI		MGSCv36	mm8
Celera	14	55,491,594 - 55,547,812 (-)	NCBI		Celera
Cytogenetic Map	14	C3	NCBI
cM Map	14	30.28	NCBI

Lats2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955497	1,711,205 - 1,761,584 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955497	1,711,882 - 1,768,177 (-)	NCBI	ChiLan1.0	ChiLan1.0

LATS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	20,603,749 - 20,692,154 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	11,716,816 - 11,805,130 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	2,300,625 - 2,389,027 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	20,610,022 - 20,698,810 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	20,611,861 - 20,683,083 (-)	Ensembl	panpan1.1		panPan2

LATS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	17,110,620 - 17,169,826 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	17,110,637 - 17,169,291 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	17,188,801 - 17,201,953 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	17,237,244 - 17,308,678 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	17,237,178 - 17,307,295 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	17,109,498 - 17,180,871 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	17,120,566 - 17,191,969 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	17,176,853 - 17,248,494 (+)	NCBI		UU_Cfam_GSD_1.0

Lats2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	119,187,750 - 119,248,054 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936720	735,524 - 793,696 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936720	735,326 - 795,596 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LATS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	1,225,527 - 1,265,946 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	1,225,523 - 1,265,970 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

LATS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	124,520 - 215,426 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666057	44,396,305 - 44,490,502 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lats2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624776	16,585,025 - 16,638,520 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624776	16,572,598 - 16,640,412 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Lats2
20 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	232
Count of miRNA genes:	150
Interacting mature miRNAs:	183
Transcripts:	ENSRNOT00000014031
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	17362897	73690657	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
10755503	Bp391	Blood pressure QTL 391	2.37		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	20248600	37896129	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	28030665	82262678	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
9589149	Insul29	Insulin level QTL 29	9.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	15	1	34723002	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
8552920	Pigfal8	Plasma insulin-like growth factor 1 level QTL 8	3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	15	1	34723002	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	11111142	56111142	Rat
8694361	Abfw6	Abdominal fat weight QTL 6	10.2	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	15	1	34723002	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	28030665	82262678	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	10596089	55596089	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
152025253	Hrtrt24	Heart rate QTL 24	3.82		heart pumping trait (VT:2000009)		15	27885774	86257085	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	22117933	67117933	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	19856566	46187442	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat
631550	Bw7	Body weight QTL 7	3.6		body mass (VT:0001259)	body weight (CMO:0000012)	15	19856566	34924750	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	28030665	82262678	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat

Markers in Region

RH139371

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	31,825,194 - 31,825,286 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	37,943,736 - 37,943,827	NCBI	Rnor6.0
Rnor_5.0	15	41,788,847 - 41,788,938	UniSTS	Rnor5.0
RGSC_v3.4	15	36,720,127 - 36,720,218	UniSTS	RGSC3.4
Celera	15	31,535,788 - 31,535,879	UniSTS
Cytogenetic Map	15	p12	UniSTS

AI233961

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	31,825,106 - 31,825,286 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	37,943,648 - 37,943,827	NCBI	Rnor6.0
Rnor_5.0	15	41,788,759 - 41,788,938	UniSTS	Rnor5.0
RGSC_v3.4	15	36,720,039 - 36,720,218	UniSTS	RGSC3.4
Celera	15	31,535,700 - 31,535,879	UniSTS
Cytogenetic Map	15	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008770748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000087978 ⟹ ENSRNOP00000072969

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	31,825,092 - 31,877,220 (-)	Ensembl
Rnor_6.0 Ensembl	15	37,943,609 - 37,983,882 (-)	Ensembl

RefSeq Acc Id:

NM_001107267 ⟹ NP_001100737

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	35,940,632 - 35,980,842 (-)	NCBI
mRatBN7.2	15	31,825,068 - 31,865,286 (-)	NCBI
Rnor_6.0	15	37,943,609 - 37,983,882 (-)	NCBI
Rnor_5.0	15	41,788,720 - 41,828,866 (-)	NCBI
RGSC_v3.4	15	36,720,000 - 36,761,065 (-)	RGD
Celera	15	31,535,661 - 31,575,853 (-)	RGD

Sequence:

show sequence

AAAGTGATGGTCTTCAAAATGAAAACTCTGGAAAATTTTAGGTTCTCTTTAGGAGCTACAGAAA
TTGAAGGAAGTTGTTCTGGAAGCATGTTTACAACTCACTGACAGTATTACCTGTTCTTAAGAAG
ATTGTATTTATGGTAAAAGGAAACTGGACTAACGATGAGGCCAAAGACTTTTCCTGCTACAACT
TACTCTGGAAATAGCCGGCAGCGACTGCAAGAGATTCGAGAAGGACTGAAGCAGCCGGCCAAGT
CTTCCACCCAGGGGCTGCTGGTGGGACCAAACAGTGACACTTCTTCCCTGGATGCCAAAGTCCT
GGGGAACAAAGATGCCTCCAGGCAGCAGCAGATGAGAGCCACCCCGAAGTTTGGACCTTATCAA
AAAGCGCTCAGGGAAATCCGATATTCCCTCCTGCCTTTTGCCAATGAGTCAGGCACGTCGGCAG
CTGCAGAGGTGAACCGGCAGATGCTGCAGGAGTTGGTGAATGCAGGATGTGACCAGGAGATGGC
TGGCAGAGCGCTCAAGCAGACAGGCAGTAGGAGTATTGAAGCCGCCTTGGAGTACATCAGTAAG
ATGGGCTACTTGGACCCCAGGAATGAGCAAATTGTGCGAGTCATCAAGCAGACCTCCCCAGGAA
AGGGCCTGGTGCCCACTGCAGTGACTCGACGACCCAGCTTTGAGGGCACAGGGGAAGCATTCCC
ATCCCACCACCAGTTGGGCGGTGCAAACTATGAGGGCCCCGCTGCCCTGGAGGAGATGCCACGG
CAATATTTAGACTTCCTCTTCCCCGGGGCCAGCGTCCACGGCGCCCCGGCTCACCAGCATCCCC
CCAAAGGCTACAGCACTGCAGTGGATGCGGGCACACACTTCCCAGGCGCACACTATGGTCGTGC
TCATCTACTGTCAGAGCAGCCTGGGTATGGGGTTCAGCGCAGCCCCTCCTTCCAGAGCAAGACG
CCACCAGACACCTATTCCAGCCTGGCCAAGGCCCAGGGTGGCCCTCCTGCCAGCCTCACCTTCC
CTGCCCATGCTGGTCTGTACACCACCTCGCACCACAAGCCAGCGGCTGCAGTACCTGGGGCCCA
CCCCTTACATGTGTTGGGCACCCGGGGCCCCACGTTCACTGGGGACAGCTCTACGCAGGCCGTT
CTGGCACCGTCCAGGAACAGCCTCAATAATGACTTGTACGAGCTGGGCTCTCCCGTGCCCTGGC
CCGCAGCTCCACTGGCACGCCGTGACTCGCTGCAGAAGCAGAGTCTAGAGGCCTCCCGGCCGCA
TGTGGCCTTCCGGGCTGGGCCCAGCAGGACCAACTCCTTCAGCAGCCCACAACCTGAGCCCTCA
CTGCCCGCCCCCAACACAGTCACTGCTGTGACGGCTGCACACATCCTTCACCCTGTGAAGAGCG
TGCGCGTGCTGCGGCCCGAGCCTCAGACAGCCGTGGGGCCCTCGCACCCCGCCTGGGTGCCTGC
CCCCACAGCACCTGCAGCCGCCGAGGGCCTGGAGAGCAAGGAGGGCAGTGCAGGCCCACCCCCG
CTGGATATGGACTTCGGGGGCTCCGAGCGCAGGTGCCCACCGCCTCCTTACCCAAAGCACTTGC
TGCTGCCCAGTAAGTCTGAGCAGTACAGCGCTGGTCTGGACCGCCTGTGCACCGGTGTGGAGCA
GAGTCTGCGCGGGGGCACCGAGCAAGACAGGAATGACAAGGGCCACAAGGGTGCTAAGGGGGAC
AAAGCTGGCAGGGACAAAAAGCAGATCCAGACCTCCCCAGTGCCTGTCCGCAAGAATAGCAGGG
ATGAAGAGAAGAGAGAGTCTCGAATCAAGAGTTACTCCCCATATGCCTTCAAATTCTTCATGGA
ACAACATGTGGAGAATGTCATCAAAACCTACCAGCAGAAGGTCAGCCGGAGGCTACAGCTGGAG
CAGGAAATGGCCAAAGCTGGACTGTGCGAGACTGAGCAGGAGCAGATGAGGAAGATCCTCTACC
AGAAGGAGTCGAACTACAACAGACTCAAGAGGGCCAAGATGGACAAGTCCATGTTTGTGAAAAT
CAAAACTCTGGGCATTGGTGCCTTTGGAGAAGTGTGCCTTGCCTGTAAGGTGGATACTCACGCT
CTGTATGCCATGAAGACGCTGAGGAAAAAAGATGTCCTGAACCGGAACCAAGTGGCCCATGTCA
AGGCTGAGAGGGACATCCTGGCTGAAGCAGACAATGAGTGGGTGGTCAAACTCTACTATTCCTT
CCAGGACAAGGACAGCCTGTACTTTGTGATGGACTACATACCTGGTGGGGACATGATGAGCCTG
CTGATCCGGATGGAGGTCTTCCCTGAACACCTCGCCCGCTTCTACATCGCAGAGCTGACTCTGG
CCATTGAGAGTGTGCACAAGATGGGCTTCATCCACAGGGACATCAAGCCTGACAACATCTTGAT
TGACCTGGATGGTCATATTAAGCTGACCGATTTTGGCCTCTGCACTGGATTCAGGTGGACTCAC
AATTCCAAGTACTACCAGAAAGGGAACCACATCAGACAGGACAGCATGGAGCCTGGTGACCTCT
GGGACGACGTTTCCAACTGTCGTTGTGGAGACAGGTTGAAGACCCTGGAGCAGAGAGCACAGAA
GCAGCACCAGAGGTGCCTGGCACATTCTCTGGTTGGGACACCAAATTACATTGCTCCTGAGGTG
CTTCTTCGCAAAGGGTACACACAGCTCTGTGACTGGTGGAGTGTCGGTGTGATTCTTTTTGAGA
TGCTGGTTGGGCAGCCACCTTTCTTGGCGCCCACCCCCACAGAAACCCAGCTGAAGGTGATCAA
CTGGGAGAACACGCTGCACATCCCTACGCAGGTGAAACTCAGTGCTGAGGCCCGAGACCTCATC
ACCAAGCTGTGCTGCGCGGCTGACTGCCGCCTGGGCAGGGACGGGGCAGATGACCTCAAGGCAC
ACCCGTTCTTCAGCACCATCGACTTTTCCCGTGACATCCGGAAACAGCCTGCACCCTACGTCCC
CACCATCAGCCACCCCATGGACACCTCCAATTTTGACCCAGTGGATGAAGAAAGCCCCTGGCAC
GAGGCCAGCGGAGAAAGTGCCAAGGCCTGGGACACGCTGGCGTCCCCCAACAGCAAGCACCCAG
AGCACGCCTTCTATGAGTTCACCTTCCGCAGGTTCTTCGACGACAATGGCTATCCCTTCCGGTG
CCCGAAGCCCTCAGAGCCGGCTGAGAGTGCAGACCCAGGGGATGCAGAGTTAGGAGGTGCGGTC
GAGGGCTGCCAGCCAGTGTATGTGTAAGGGGCCCGTGGCCTCAGTTGATCACAACTTGAGGAAA
CCCCAAACCAGATGTTTTTCAAAAGACAAACTGAAGCTTAGAAATCCTTCATTTTTAGCTCTGG
TTAATGGGCAACAGGAAGGGTCACCATGACATCGAATTATCCCTTTGAGGACTTTCACTGCGTT
AAAACAATATTTTTAAAAATTTAGTACAGTATGGAAAGAGCACTTATTTTATGGACACCCATTT
TTTCTTACTAAATTATAAGGACTGACTGACAAACCATGCTGCTGTTACTCCCGTTGTGTCGTAT
CTGATAGCACTTGTCCACATTAGGAAAGGAAGCCCTGAAGACCGCGTGGTGAGAAGTCTGTGCA
ATAAGAGAGAATGAGGCCGGGCTCTGCTCCAAGTCAGGAGGACCGTCTATCTACACAGTGGCTT
TGTTTTGCATTTTCCCACATTTCAAATTGTGATGTAATGTTAAAAAGCTGCTTTTGTGTGTTTT
TTCTTTGCATATTAGAGTTCCTAGAGAGTGAGCGCAGAGACGGTGGGTGTGACTCCGGTGTCTG
GTGTGGAGAGAGAGTACTGCATGAGCAGAGCTTCCTAGTCTAAAGTTACCGTATCTTGCCATTC
ACAGCAGGTCCTGTGAATACGTTTTTTAAATGAGGTATTCTAGACAGTGTGCAGATAATGTATT
GTGTGGGTGATGATTGTAGCCCTTATTGTTAAAGAAGTGCATATGTATAACTGAAGTGTGACTT
TTTTTTTAATGTGTGTGTCTTGAATATGACTGGGTTCTTTGGGAGGCAAATGTAAACGTTTGTC
ATATATAAAACACATCAAAAGGGATTAAATCAGCTATGCCAAAACATTGGACGTAATTAGAGCG
TTTTGTCCATTTCTCTAGTCCAGTACGCTGTCAGGCTTGGTGTGTAGACAGCTAGAGCTGGGAC
CCTGCTACTTCATATCGTCACATACAGGGTTCCCACAGCAAAAGGTGATGTAAGTCCTTCCTGC
TTTCTCGACAGCCAGGAGGTCCCGTGAAACTCAGTTCTCTCTGCATCTTTCATATGTGAGGTGT
CTGTCACATCTCAATGTGGCTTAATCAATACGTTTTTCCAACTTTGTAAAAAGAAAAACAGATT
CTTCGAAGTGACATTGGAGTACAAAAACAAGCCATACTTTTTTTCTTAGACATATAGGTGTGTA
TATAACTATAGATAAACACACAAAATATTCCTTATTTCAAATTAGTACGCTTCCTACATAAGGT
GATTTATATTTGAGTACATTCAATTTCTTTTGCTTTTTAAAGGATGGAATGCATCACATTTTCG
TCATACTATTCCACATACTTTCATTGAGGTTCTTAGCACAGTGTATCCGTTACTTAATATGTAT
CTAGGCAGAAACACTTACAAATTTATCTATGTCTAAGAAACATTCCCGTGTCCTGGTTTACATT
TGTATGAATGGCATGTTCTGGTCTGCTGTGCTTGTATTGTGACTTACAGTATTCTTGCTATTTT
GTAGTAATGCCGTGTTATTTACAGCGCTCTGACATAGTTTCATGTGGTAGGTTCTTTCTCAGGA
ACTCAATTTAACTATTATTTATTGATATATCATTGCCTTTGAAAGCTTCTACTGGCACAATTTA
TTATTAAAACTTTAAACCCTAGTCTCTTCA

hide sequence

RefSeq Acc Id:

XM_008770748 ⟹ XP_008768970

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	35,940,641 - 35,992,225 (-)	NCBI
mRatBN7.2	15	31,825,077 - 31,876,668 (-)	NCBI
Rnor_6.0	15	37,943,618 - 37,995,175 (-)	NCBI

Sequence:

show sequence

TCCCGGAGCCGCGGGCAAGGACGCCGCTGAGGGTGTAGAGCGCTCCCGGAGAAAGTGATGGTCT
TCAAAATGAAAACTCTGGAAAATTTTAGGTTCTCTTTAGGAGCTACAGAAATTGAAGGAAGTTG
TTCTGGAAGCATGTTTACAACTCACTGACAGTATTACCTGTTCTTAAGAAGATTGTATTTATGG
TAAAAGGAAACTGGACTAACGATGAGGCCAAAGACTTTTCCTGCTACAACTTACTCTGGAAATA
GCCGGCAGCGACTGCAAGAGATTCGAGAAGGACTGAAGCAGCCGGCCAAGTCTTCCACCCAGGG
GCTGCTGGTGGGACCAAACAGTGACACTTCTTCCCTGGATGCCAAAGTCCTGGGGAACAAAGAT
GCCTCCAGGCAGCAGCAGATGAGAGCCACCCCGAAGTTTGGACCTTATCAAAAAGCGCTCAGGG
AAATCCGATATTCCCTCCTGCCTTTTGCCAATGAGTCAGGCACGTCGGCAGCTGCAGAGGTGAA
CCGGCAGATGCTGCAGGAGTTGGTGAATGCAGGATGTGACCAGGAGATGGCTGGCAGAGCGCTC
AAGCAGACAGGCAGTAGGAGTATTGAAGCCGCCTTGGAGTACATCAGTAAGATGGGCTACTTGG
ACCCCAGGAATGAGCAAATTGTGCGAGTCATCAAGCAGACCTCCCCAGGAAAGGGCCTGGTGCC
CACTGCAGTGACTCGACGACCCAGCTTTGAGGGCACAGGGGAAGCATTCCCATCCCACCACCAG
TTGGGCGGTGCAAACTATGAGGGCCCCGCTGCCCTGGAGGAGATGCCACGGCAATATTTAGACT
TCCTCTTCCCCGGGGCCAGCGTCCACGGCGCCCCGGCTCACCAGCATCCCCCCAAAGGCTACAG
CACTGCAGTGGATGCGGGCACACACTTCCCAGGCGCACACTATGGTCGTGCTCATCTACTGTCA
GAGCAGCCTGGGTATGGGGTTCAGCGCAGCCCCTCCTTCCAGAGCAAGACGCCACCAGACACCT
ATTCCAGCCTGGCCAAGGCCCAGGGTGGCCCTCCTGCCAGCCTCACCTTCCCTGCCCATGCTGG
TCTGTACACCACCTCGCACCACAAGCCAGCGGCTGCAGTACCTGGGGCCCACCCCTTACATGTG
TTGGGCACCCGGGGCCCCACGTTCACTGGGGACAGCTCTACGCAGGCCGTTCTGGCACCGTCCA
GGAACAGCCTCAATAATGACTTGTACGAGCTGGGCTCTCCCGTGCCCTGGCCCGCAGCTCCACT
GGCACGCCGTGACTCGCTGCAGAAGCAGAGTCTAGAGGCCTCCCGGCCGCATGTGGCCTTCCGG
GCTGGGCCCAGCAGGACCAACTCCTTCAGCAGCCCACAACCTGAGCCCTCACTGCCCGCCCCCA
ACACAGTCACTGCTGTGACGGCTGCACACATCCTTCACCCTGTGAAGAGCGTGCGCGTGCTGCG
GCCCGAGCCTCAGACAGCCGTGGGGCCCTCGCACCCCGCCTGGGTGCCTGCCCCCACAGCACCT
GCAGCCGCCGAGGGCCTGGAGAGCAAGGAGGGCAGTGCAGGCCCACCCCCGCTGGATATGGACT
TCGGGGGCTCCGAGCGCAGGTGCCCACCGCCTCCTTACCCAAAGCACTTGCTGCTGCCCAGTAA
GTCTGAGCAGTACAGCGCTGGTCTGGACCGCCTGTGCACCGGTGTGGAGCAGAGTCTGCGCGGG
GGCACCGAGCAAGACAGGAATGACAAGGGCCACAAGGGTGCTAAGGGGGACAAAGCTGGCAGGG
ACAAAAAGCAGATCCAGACCTCCCCAGTGCCTGTCCGCAAGAATAGCAGGGATGAAGAGAAGAG
AGAGTCTCGAATCAAGAGTTACTCCCCATATGCCTTCAAATTCTTCATGGAACAACATGTGGAG
AATGTCATCAAAACCTACCAGCAGAAGGTCAGCCGGAGGCTACAGCTGGAGCAGGAAATGGCCA
AAGCTGGACTGTGCGAGACTGAGCAGGAGCAGATGAGGAAGATCCTCTACCAGAAGGAGTCGAA
CTACAACAGACTCAAGAGGGCCAAGATGGACAAGTCCATGTTTGTGAAAATCAAAACTCTGGGC
ATTGGTGCCTTTGGAGAAGTGTGCCTTGCCTGTAAGGTGGATACTCACGCTCTGTATGCCATGA
AGACGCTGAGGAAAAAAGATGTCCTGAACCGGAACCAAGTGGCCCATGTCAAGGCTGAGAGGGA
CATCCTGGCTGAAGCAGACAATGAGTGGGTGGTCAAACTCTACTATTCCTTCCAGGACAAGGAC
AGCCTGTACTTTGTGATGGACTACATACCTGGTGGGGACATGATGAGCCTGCTGATCCGGATGG
AGGTCTTCCCTGAACACCTCGCCCGCTTCTACATCGCAGAGCTGACTCTGGCCATTGAGAGTGT
GCACAAGATGGGCTTCATCCACAGGGACATCAAGCCTGACAACATCTTGATTGACCTGGATGGT
CATATTAAGCTGACCGATTTTGGCCTCTGCACTGGATTCAGGTGGACTCACAATTCCAAGTACT
ACCAGAAAGGGAACCACATCAGACAGGACAGCATGGAGCCTGGTGACCTCTGGGACGACGTTTC
CAACTGTCGTTGTGGAGACAGGTTGAAGACCCTGGAGCAGAGAGCACAGAAGCAGCACCAGAGG
TGCCTGGCACATTCTCTGGTTGGGACACCAAATTACATTGCTCCTGAGGTGCTTCTTCGCAAAG
GGTACACACAGCTCTGTGACTGGTGGAGTGTCGGTGTGATTCTTTTTGAGATGCTGGTTGGGCA
GCCACCTTTCTTGGCGCCCACCCCCACAGAAACCCAGCTGAAGGTGATCAACTGGGAGAACACG
CTGCACATCCCTACGCAGGTGAAACTCAGTGCTGAGGCCCGAGACCTCATCACCAAGCTGTGCT
GCGCGGCTGACTGCCGCCTGGGCAGGGACGGGGCAGATGACCTCAAGGCACACCCGTTCTTCAG
CACCATCGACTTTTCCCGTGACATCCGGAAACAGCCTGCACCCTACGTCCCCACCATCAGCCAC
CCCATGGACACCTCCAATTTTGACCCAGTGGATGAAGAAAGCCCCTGGCACGAGGCCAGCGGAG
AAAGTGCCAAGGCCTGGGACACGCTGGCGTCCCCCAACAGCAAGCACCCAGAGCACGCCTTCTA
TGAGTTCACCTTCCGCAGGTTCTTCGACGACAATGGCTATCCCTTCCGGTGCCCGAAGCCCTCA
GAGCCGGCTGAGAGTGCAGACCCAGGGGATGCAGAGTTAGGAGGTGCGGTCGAGGGCTGCCAGC
CAGTGTATGTGTAAGGGGCCCGTGGCCTCAGTTGATCACAACTTGAGGAAACCCCAAACCAGAT
GTTTTTCAAAAGACAAACTGAAGCTTAGAAATCCTTCATTTTTAGCTCTGGTTAATGGGCAACA
GGAAGGGTCACCATGACATCGAATTATCCCTTTGAGGACTTTCACTGCGTTAAAACAATATTTT
TAAAAATTTAGTACAGTATGGAAAGAGCACTTATTTTATGGACACCCATTTTTTCTTACTAAAT
TATAAGGACTGACTGACAAACCATGCTGCTGTTACTCCCGTTGTGTCGTATCTGATAGCACTTG
TCCACATTAGGAAAGGAAGCCCTGAAGACCGCGTGGTGAGAAGTCTGTGCAATAAGAGAGAATG
AGGCCGGGCTCTGCTCCAAGTCAGGAGGACCGTCTATCTACACAGTGGCTTTGTTTTGCATTTT
CCCACATTTCAAATTGTGATGTAATGTTAAAAAGCTGCTTTTGTGTGTTTTTTCTTTGCATATT
AGAGTTCCTAGAGAGTGAGCGCAGAGACGGTGGGTGTGACTCCGGTGTCTGGTGTGGAGAGAGA
GTACTGCATGAGCAGAGCTTCCTAGTCTAAAGTTACCGTATCTTGCCATTCACAGCAGGTCCTG
TGAATACGTTTTTTAAATGAGGTATTCTAGACAGTGTGCAGATAATGTATTGTGTGGGTGATGA
TTGTAGCCCTTATTGTTAAAGAAGTGCATATGTATAACTGAAGTGTGACTTTTTTTTTAATGTG
TGTGTCTTGAATATGACTGGGTTCTTTGGGAGGCAAATGTAAACGTTTGTCATATATAAAACAC
ATCAAAAGGGATTAAATCAGCTATGCCAAAACATTGGACGTAATTAGAGCGTTTTGTCCATTTC
TCTAGTCCAGTACGCTGTCAGGCTTGGTGTGTAGACAGCTAGAGCTGGGACCCTGCTACTTCAT
ATCGTCACATACAGGGTTCCCACAGCAAAAGGTGATGTAAGTCCTTCCTGCTTTCTCGACAGCC
AGGAGGTCCCGTGAAACTCAGTTCTCTCTGCATCTTTCATATGTGAGGTGTCTGTCACATCTCA
ATGTGGCTTAATCAATACGTTTTTCCAACTTTGTAAAAAGAAAAACAGATTCTTCGAAGTGACA
TTGGAGTACAAAAACAAGCCATACTTTTTTTCTTAGACATATAGGTGTGTATATAACTATAGAT
AAACACACAAAATATTCCTTATTTCAAATTAGTACGCTTCCTACATAAGGTGATTTATATTTGA
GTACATTCAATTTCTTTTGCTTTTTAAAGGATGGAATGCATCACATTTTCGTCATACTATTCCA
CATACTTTCATTGAGGTTCTTAGCACAGTGTATCCGTTACTTAATATGTATCTAGGCAGAAACA
CTTACAAATTTATCTATGTCTAAGAAACATTCCCGTGTCCTGGTTTACATTTGTATGAATGGCA
TGTTCTGGTCTGCTGTGCTTGTATTGTGACTTACAGTATTCTTGCTATTTTGTAGTAATGCCGT
GTTATTTACAGCGCTCTGACATAGTTTCATGTGGTAGGTTCTTTCTCAGGAACTCAATTTAACT
ATTATTTATTGATATATCATTGCCTTTGAAAGCTTCTACTGGCACAATTTATTATTAAAACTTT
AAACCCTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100737	(Get FASTA)	NCBI Sequence Viewer
	XP_008768970	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM14356	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000072969
	ENSRNOP00000072969.1

RefSeq Acc Id:

NP_001100737 ⟸ NM_001107267

- UniProtKB:

A0A0G2K4A8 (UniProtKB/TrEMBL), A6KHC7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRPKTFPATTYSGNSRQRLQEIREGLKQPAKSSTQGLLVGPNSDTSSLDAKVLGNKDASRQQQM
RATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRS
IEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLVPTAVTRRPSFEGTGEAFPSHHQLGGANYE
GPAALEEMPRQYLDFLFPGASVHGAPAHQHPPKGYSTAVDAGTHFPGAHYGRAHLLSEQPGYGV
QRSPSFQSKTPPDTYSSLAKAQGGPPASLTFPAHAGLYTTSHHKPAAAVPGAHPLHVLGTRGPT
FTGDSSTQAVLAPSRNSLNNDLYELGSPVPWPAAPLARRDSLQKQSLEASRPHVAFRAGPSRTN
SFSSPQPEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPTAPAAAEGLE
SKEGSAGPPPLDMDFGGSERRCPPPPYPKHLLLPSKSEQYSAGLDRLCTGVEQSLRGGTEQDRN
DKGHKGAKGDKAGRDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQ
QKVSRRLQLEQEMAKAGLCETEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEV
CLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMD
YIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDF
GLCTGFRWTHNSKYYQKGNHIRQDSMEPGDLWDDVSNCRCGDRLKTLEQRAQKQHQRCLAHSLV
GTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPTQV
KLSAEARDLITKLCCAADCRLGRDGADDLKAHPFFSTIDFSRDIRKQPAPYVPTISHPMDTSNF
DPVDEESPWHEASGESAKAWDTLASPNSKHPEHAFYEFTFRRFFDDNGYPFRCPKPSEPAESAD
PGDAELGGAVEGCQPVYV

hide sequence

RefSeq Acc Id:	XP_008768970 ⟸ XM_008770748
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K4A8 (UniProtKB/TrEMBL), A6KHC7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRPKTFPATTYSGNSRQRLQEIREGLKQPAKSSTQGLLVGPNSDTSSLDAKVLGNKDASRQQQM RATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRS IEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLVPTAVTRRPSFEGTGEAFPSHHQLGGANYE GPAALEEMPRQYLDFLFPGASVHGAPAHQHPPKGYSTAVDAGTHFPGAHYGRAHLLSEQPGYGV QRSPSFQSKTPPDTYSSLAKAQGGPPASLTFPAHAGLYTTSHHKPAAAVPGAHPLHVLGTRGPT FTGDSSTQAVLAPSRNSLNNDLYELGSPVPWPAAPLARRDSLQKQSLEASRPHVAFRAGPSRTN SFSSPQPEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPTAPAAAEGLE SKEGSAGPPPLDMDFGGSERRCPPPPYPKHLLLPSKSEQYSAGLDRLCTGVEQSLRGGTEQDRN DKGHKGAKGDKAGRDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQ QKVSRRLQLEQEMAKAGLCETEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEV CLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMD YIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDF GLCTGFRWTHNSKYYQKGNHIRQDSMEPGDLWDDVSNCRCGDRLKTLEQRAQKQHQRCLAHSLV GTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPTQV KLSAEARDLITKLCCAADCRLGRDGADDLKAHPFFSTIDFSRDIRKQPAPYVPTISHPMDTSNF DPVDEESPWHEASGESAKAWDTLASPNSKHPEHAFYEFTFRRFFDDNGYPFRCPKPSEPAESAD PGDAELGGAVEGCQPVYV hide sequence

Ensembl Acc Id:

ENSRNOP00000072969 ⟸ ENSRNOT00000087978

Protein Domains

AGC-kinase C-terminal Protein kinase UBA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K4A8-F1-model_v2	AlphaFold	A0A0G2K4A8	1-1042	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305906	AgrOrtholog
BioCyc Gene	G2FUF-13598	BioCyc
Ensembl Genes	ENSRNOG00000056343	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000087978	ENTREZGENE
	ENSRNOT00000087978.2	UniProtKB/TrEMBL
Gene3D-CATH	DNA helicase RuvA subunit, C-terminal domain	UniProtKB/TrEMBL
	Phosphorylase Kinase, domain 1	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	AGC-kinase_C	UniProtKB/TrEMBL
	Kinase-like_dom	UniProtKB/TrEMBL
	Pkinase_C	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
	Ser_Thr_kinase_AGC	UniProtKB/TrEMBL
	UBA-like	UniProtKB/TrEMBL
	UBA/transl_elong_EF1B_N_euk	UniProtKB/TrEMBL
KEGG Report	rno:305922	UniProtKB/TrEMBL
NCBI Gene	305922	ENTREZGENE
PANTHER	PTHR24356:SF149	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
	Pkinase_C	UniProtKB/TrEMBL
PhenoGen	Lats2	PhenoGen
PROSITE	AGC_KINASE_CTER	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
	UBA	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000056343	RatGTEx
SMART	S_TK_X	UniProtKB/TrEMBL
	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
	UBA_like	UniProtKB/TrEMBL
UniProt	A0A0G2K4A8	ENTREZGENE, UniProtKB/TrEMBL
	A6KHC7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-02-26	Lats2	large tumor suppressor kinase 2	Lats2	large tumor suppressor 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-19	Lats2	large tumor suppressor 2	Lats2	large tumor suppressor, homolog 2 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-01-17	Lats2	large tumor suppressor, homolog 2 (Drosophila)	Lats2	large tumor suppressor 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Lats2	large tumor suppressor 2	Lats2_predicted	large tumor suppressor 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Lats2_predicted	large tumor suppressor 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD