Champ1 (chromosome alignment maintaining phosphoprotein 1) - Rat Genome Database

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Gene: Champ1 (chromosome alignment maintaining phosphoprotein 1) Rattus norvegicus
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Symbol: Champ1
Name: chromosome alignment maintaining phosphoprotein 1
RGD ID: 1311283
Description: Predicted to be involved in attachment of spindle microtubules to kinetochore and protein localization to organelle. Predicted to be located in Flemming body; kinetochore; and nuclear body. Predicted to be active in nucleoplasm and spindle. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 40. Orthologous to human CHAMP1 (chromosome alignment maintaining phosphoprotein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: chromosome alignment-maintaining phosphoprotein 1; LOC306647; RGD1311283; similar to Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H); Zfp828; zinc finger protein 828
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21675,733,958 - 75,744,977 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1675,733,805 - 75,744,984 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,014,434 - 81,025,580 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01684,467,964 - 84,479,110 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01679,717,822 - 79,728,765 (-)NCBIRnor_WKY
Rnor_6.01680,839,373 - 80,850,340 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1680,839,374 - 80,850,340 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01680,403,594 - 80,414,561 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41680,569,713 - 80,573,705 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11680,571,519 - 80,573,925 (-)NCBI
Celera1673,542,848 - 73,553,807 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
condensed chromosome  (ISO)
Flemming body  (ISO)
kinetochore  (ISO)
nuclear body  (ISO)
nucleoplasm  (IBA,ISO)
nucleus  (ISO)
spindle  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16176808   PMID:17070521   PMID:21063390  


Genomics

Comparative Map Data
Champ1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21675,733,958 - 75,744,977 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1675,733,805 - 75,744,984 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,014,434 - 81,025,580 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01684,467,964 - 84,479,110 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01679,717,822 - 79,728,765 (-)NCBIRnor_WKY
Rnor_6.01680,839,373 - 80,850,340 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1680,839,374 - 80,850,340 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01680,403,594 - 80,414,561 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41680,569,713 - 80,573,705 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11680,571,519 - 80,573,925 (-)NCBI
Celera1673,542,848 - 73,553,807 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
CHAMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813114,314,503 - 114,327,322 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl13114,314,482 - 114,337,626 (+)EnsemblGRCh38hg38GRCh38
GRCh3713115,079,978 - 115,092,797 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613114,098,117 - 114,110,899 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413114,098,116 - 114,110,898NCBI
Celera1395,752,593 - 95,765,430 (+)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1395,342,333 - 95,355,170 (+)NCBIHuRef
CHM1_113115,048,734 - 115,061,571 (+)NCBICHM1_1
T2T-CHM13v2.013113,523,561 - 113,536,364 (+)NCBIT2T-CHM13v2.0
Champ1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,919,641 - 13,931,639 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,919,641 - 13,931,639 (+)EnsemblGRCm39 Ensembl
GRCm38813,869,641 - 13,881,639 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,869,641 - 13,881,639 (+)EnsemblGRCm38mm10GRCm38
MGSCv37813,869,641 - 13,881,639 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36813,869,706 - 13,880,546 (+)NCBIMGSCv36mm8
Celera814,029,945 - 14,041,943 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map86.4NCBI
Champ1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554044,445 - 6,877 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554043,228 - 14,695 (-)NCBIChiLan1.0ChiLan1.0
CHAMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.113114,454,742 - 114,460,958 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13114,457,481 - 114,459,919 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01395,382,649 - 95,411,763 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CHAMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12261,367,007 - 61,378,111 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2261,368,049 - 61,378,111 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2261,078,383 - 61,089,567 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02262,053,743 - 62,064,929 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2262,052,677 - 62,068,946 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12261,491,295 - 61,502,477 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02261,497,927 - 61,508,902 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02261,526,892 - 61,538,074 (-)NCBIUU_Cfam_GSD_1.0
Champ1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945196,220,651 - 196,229,951 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004937030268,400 - 279,341 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHAMP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1392,104,268 - 92,119,018 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl392,115,535 - 92,117,976 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604649,399,494 - 49,414,401 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Champ1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624793111,025 - 113,526 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624793109,854 - 121,461 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Champ1
70 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:361
Count of miRNA genes:224
Interacting mature miRNAs:264
Transcripts:ENSRNOT00000000124
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
AU049290  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16q12.5UniSTS
RH129359  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21675,734,116 - 75,734,317 (+)MAPPERmRatBN7.2
Rnor_6.01680,839,532 - 80,839,732NCBIRnor6.0
Rnor_5.01680,403,753 - 80,403,953UniSTSRnor5.0
RGSC_v3.41680,569,868 - 80,570,068UniSTSRGSC3.4
Celera1673,543,003 - 73,543,203UniSTS
RH 3.4 Map16731.2UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 24 12 18 12 67 29 34 11
Low 17 33 29 1 29 8 11 7 6 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000124   ⟹   ENSRNOP00000000124
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1675,733,805 - 75,744,984 (-)Ensembl
Rnor_6.0 Ensembl1680,839,374 - 80,850,340 (-)Ensembl
RefSeq Acc Id: NM_001107329   ⟹   NP_001100799
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21675,733,962 - 75,744,919 (-)NCBI
Rnor_6.01680,839,377 - 80,850,340 (-)NCBI
Rnor_5.01680,403,594 - 80,414,561 (-)NCBI
RGSC_v3.41680,569,713 - 80,573,705 (-)RGD
Celera1673,542,848 - 73,553,807 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253396   ⟹   XP_006253458
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21675,733,958 - 75,744,977 (-)NCBI
Rnor_6.01680,839,373 - 80,850,340 (-)NCBI
Rnor_5.01680,403,594 - 80,414,561 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001100799 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253458 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68662 (Get FASTA)   NCBI Sequence Viewer  
  EDM08915 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100799   ⟸   NM_001107329
- UniProtKB: B5DEG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253458   ⟸   XM_006253396
- Peptide Label: isoform X1
- UniProtKB: B5DEG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000124   ⟸   ENSRNOT00000000124
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DEG7-F1-model_v2 AlphaFold B5DEG7 1-801 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311283 AgrOrtholog
BioCyc Gene G2FUF-10737 BioCyc
Ensembl Genes ENSRNOG00000000112 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000124 ENTREZGENE
  ENSRNOP00000000124.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000124 ENTREZGENE
  ENSRNOT00000000124.6 UniProtKB/TrEMBL
InterPro CAMP UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:306647 UniProtKB/TrEMBL
NCBI Gene 306647 ENTREZGENE
PANTHER PTHR37354 UniProtKB/TrEMBL
PhenoGen Champ1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt B5DEG7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-27 Champ1  chromosome alignment maintaining phosphoprotein 1  Zfp828  zinc finger protein 828  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-31 Zfp828  zinc finger protein 828  RGD1311283_predicted  similar to Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1311283_predicted  similar to Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H) (predicted)  LOC306647_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC306647_predicted  similar to Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL