Atp6v1b2 (ATPase H+ transporting V1 subunit B2) - Rat Genome Database

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Gene: Atp6v1b2 (ATPase H+ transporting V1 subunit B2) Rattus norvegicus
Analyze
Symbol: Atp6v1b2
Name: ATPase H+ transporting V1 subunit B2
RGD ID: 620284
Description: Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in vacuolar acidification. Is integral component of membrane. Part of vacuolar proton-transporting V-type ATPase, V1 domain. Human ortholog(s) of this gene implicated in autosomal dominant congenital deafness with onychodystrophy. Orthologous to human ATP6V1B2 (ATPase H+ transporting V1 subunit B2); PARTICIPATES IN oxidative phosphorylation pathway; phagocytosis pathway; rheumatoid arthritis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Atp6b1b2; Atp6b2; ATPase, H transporting, lysosomal V1 subunit B2; ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa; ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 2; ATPase, H+ transporting, V1 subunit B; ATPase, H+ transporting, V1 subunit B, isoform 2; endomembrane proton pump 58 kDa subunit; V-ATPase; V-ATPase subunit B 2; V-type proton ATPase subunit B, brain isoform; vacuolar H+ATPase B2; vacuolar proton pump subunit B 2; Vatb
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21620,617,515 - 20,641,651 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1620,617,518 - 20,641,745 (-)Ensembl
Rnor_6.01622,326,537 - 22,350,143 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1622,326,529 - 22,350,155 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01622,221,011 - 22,244,664 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41622,320,425 - 22,344,445 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11622,320,425 - 22,344,443 (-)NCBI
Celera1620,593,372 - 20,617,306 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
azoxystrobin  (ISO)
benzatropine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (EXP)
carbon nanotube  (EXP,ISO)
chloropicrin  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
CU-O LINKAGE  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
diethylstilbestrol  (EXP,ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenpyroximate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
haloperidol  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
Methylazoxymethanol acetate  (EXP)
microcystin  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (EXP)
phenylpropanolamine  (ISO)
picoxystrobin  (ISO)
quartz  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
sodium arsenite  (EXP)
T-2 toxin  (EXP)
tebufenpyrad  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structure of V-ATPase from the mammalian brain. Abbas YM, etal., Science. 2020 Mar 13;367(6483):1240-1246. doi: 10.1126/science.aaz2924.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis. Paunescu TG, etal., Am J Physiol Cell Physiol 2004 Jul;287(1):C149-62. Epub 2004 Mar 10.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Information Derived from GenBank Report RGD, Sept. 2003
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16177003   PMID:17392376   PMID:17634366   PMID:17897319   PMID:17898041   PMID:17959750   PMID:18667600   PMID:19056867   PMID:19199708   PMID:19396617  
PMID:20169059   PMID:21700703   PMID:22245629   PMID:22467241   PMID:22871113   PMID:23376485   PMID:23533145   PMID:29476059   PMID:32357304  


Genomics

Comparative Map Data
Atp6v1b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21620,617,515 - 20,641,651 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1620,617,518 - 20,641,745 (-)Ensembl
Rnor_6.01622,326,537 - 22,350,143 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1622,326,529 - 22,350,155 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01622,221,011 - 22,244,664 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41622,320,425 - 22,344,445 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11622,320,425 - 22,344,443 (-)NCBI
Celera1620,593,372 - 20,617,306 (-)NCBICelera
Cytogenetic Map16p14NCBI
ATP6V1B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38820,197,381 - 20,221,696 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl820,197,381 - 20,226,819 (+)EnsemblGRCh38hg38GRCh38
GRCh37820,054,892 - 20,079,207 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36820,098,984 - 20,123,487 (+)NCBINCBI36hg18NCBI36
Build 34820,098,983 - 20,123,485NCBI
Celera819,017,312 - 19,041,815 (+)NCBI
Cytogenetic Map8p21.3NCBI
HuRef818,594,885 - 18,619,391 (+)NCBIHuRef
CHM1_1820,256,468 - 20,280,970 (+)NCBICHM1_1
T2T-CHM13v2.0820,462,474 - 20,486,792 (+)NCBI
Atp6v1b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39869,541,388 - 69,566,370 (+)NCBIGRCm39mm39
GRCm39 Ensembl869,541,298 - 69,566,363 (+)Ensembl
GRCm38869,088,736 - 69,113,718 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl869,088,646 - 69,113,711 (+)EnsemblGRCm38mm10GRCm38
MGSCv37871,612,635 - 71,637,617 (+)NCBIGRCm37mm9NCBIm37
MGSCv36872,017,774 - 72,042,696 (+)NCBImm8
Celera871,638,588 - 71,664,008 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
Atp6v1b2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540343,860,728 - 43,886,732 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540343,860,811 - 43,886,398 (+)NCBIChiLan1.0ChiLan1.0
ATP6V1B2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1816,369,937 - 16,394,284 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl816,369,937 - 16,394,284 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0819,422,423 - 19,446,799 (+)NCBIMhudiblu_PPA_v0panPan3
ATP6V1B2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12536,833,246 - 36,858,846 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2536,834,196 - 36,858,819 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2537,427,758 - 37,453,358 (-)NCBI
ROS_Cfam_1.02537,060,323 - 37,085,593 (-)NCBI
ROS_Cfam_1.0 Ensembl2537,058,861 - 37,085,557 (-)Ensembl
UMICH_Zoey_3.12536,996,082 - 37,021,279 (-)NCBI
UNSW_CanFamBas_1.02536,844,258 - 36,869,790 (-)NCBI
UU_Cfam_GSD_1.02537,013,339 - 37,038,613 (-)NCBI
Atp6v1b2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494314,261,909 - 14,285,067 (-)NCBI
SpeTri2.0NW_0049365554,285,269 - 4,307,715 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP6V1B2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl144,289,339 - 4,318,584 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1144,289,257 - 4,318,587 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2144,718,964 - 4,748,253 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATP6V1B2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1818,264,210 - 18,289,951 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl818,264,329 - 18,293,444 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605223,963,087 - 23,988,457 (-)NCBIVero_WHO_p1.0
Atp6v1b2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475815,910,132 - 15,935,160 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462475815,910,189 - 15,933,975 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AI790362  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21620,618,272 - 20,618,362 (+)MAPPERmRatBN7.2
Rnor_6.01622,327,295 - 22,327,384NCBIRnor6.0
Rnor_5.01622,221,769 - 22,221,858UniSTSRnor5.0
RGSC_v3.41622,321,183 - 22,321,272UniSTSRGSC3.4
Celera1620,594,130 - 20,594,219UniSTS
Cytogenetic Map16p14UniSTS
BI279710  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21620,617,897 - 20,618,078 (+)MAPPERmRatBN7.2
Rnor_6.01622,326,920 - 22,327,100NCBIRnor6.0
Rnor_5.01622,221,394 - 22,221,574UniSTSRnor5.0
RGSC_v3.41622,320,808 - 22,320,988UniSTSRGSC3.4
Celera1620,593,755 - 20,593,935UniSTS
Cytogenetic Map16p14UniSTS
AU046373  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21620,638,872 - 20,639,106 (+)MAPPERmRatBN7.2
Rnor_6.01622,347,365 - 22,347,598NCBIRnor6.0
Rnor_5.01622,241,886 - 22,242,119UniSTSRnor5.0
RGSC_v3.41622,341,667 - 22,341,900UniSTSRGSC3.4
Celera1620,614,528 - 20,614,761UniSTS
Cytogenetic Map16p14UniSTS
Atp6b1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21620,627,072 - 20,627,703 (+)MAPPERmRatBN7.2
Rnor_6.01622,336,095 - 22,336,725NCBIRnor6.0
Rnor_5.01622,230,569 - 22,231,199UniSTSRnor5.0
RGSC_v3.41622,329,983 - 22,330,613UniSTSRGSC3.4
Celera1620,602,930 - 20,603,560UniSTS
Cytogenetic Map16p14UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8hepatic copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:190
Count of miRNA genes:128
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000015931
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015931   ⟹   ENSRNOP00000015931
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1620,617,521 - 20,641,745 (-)Ensembl
Rnor_6.0 Ensembl1622,326,529 - 22,350,155 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103109   ⟹   ENSRNOP00000090370
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1620,617,518 - 20,634,929 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104552   ⟹   ENSRNOP00000090567
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1620,617,518 - 20,641,638 (-)Ensembl
RefSeq Acc Id: NM_057213   ⟹   NP_476561
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21620,617,515 - 20,641,651 (-)NCBI
Rnor_6.01622,326,537 - 22,350,143 (-)NCBI
Rnor_5.01622,221,011 - 22,244,664 (-)NCBI
RGSC_v3.41622,320,425 - 22,344,445 (-)RGD
Celera1620,593,372 - 20,617,306 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_476561 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85714 (Get FASTA)   NCBI Sequence Viewer  
  CAA73183 (Get FASTA)   NCBI Sequence Viewer  
  EDL84666 (Get FASTA)   NCBI Sequence Viewer  
  EDL84667 (Get FASTA)   NCBI Sequence Viewer  
  P62815 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_476561   ⟸   NM_057213
- UniProtKB: P50517 (UniProtKB/Swiss-Prot),   P62815 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015931   ⟸   ENSRNOT00000015931
RefSeq Acc Id: ENSRNOP00000090370   ⟸   ENSRNOT00000103109
RefSeq Acc Id: ENSRNOP00000090567   ⟸   ENSRNOT00000104552
Protein Domains
ATP-synt_ab   ATP-synt_ab_N

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62815-F1-model_v2 AlphaFold P62815 1-511 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700056
Promoter ID:EPDNEW_R10580
Type:multiple initiation site
Name:Atp6v1b2_1
Description:ATPase H+ transporting V1 subunit B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01622,350,154 - 22,350,214EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620284 AgrOrtholog
BioCyc Gene G2FUF-11703 BioCyc
BioCyc Pathway PWY-7980 [ATP biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000011891 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015931 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000090370.1 UniProtKB/TrEMBL
  ENSRNOP00000090567.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015931 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000103109.1 UniProtKB/TrEMBL
  ENSRNOT00000104552.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109340 IMAGE-MGC_LOAD
InterPro ATPase_a/bsu_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_F1/V1/A1_a/bsu_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_F1/V1/A1_a/bsu_nucl-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_V1-cplx_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V-ATPase_su_B/beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117596 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93249 IMAGE-MGC_LOAD
NCBI Gene 117596 ENTREZGENE
PANTHER PTHR43389 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ATP-synt_ab UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-synt_ab_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atp6v1b2 PhenoGen
PIRSF V-ATPsynth_beta/V-ATPase_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ATPASE_ALPHA_BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs V-ATPase_V1_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ADT2_RAT UniProtKB/TrEMBL
  A0A8I6AE86_RAT UniProtKB/TrEMBL
  P50517 ENTREZGENE
  P62815 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O09045 UniProtKB/Swiss-Prot
  P50517 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Atp6v1b2  ATPase H+ transporting V1 subunit B2  Atp6v1b2  ATPase, H transporting, lysosomal V1 subunit B2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Atp6v1b2  ATPase, H transporting, lysosomal V1 subunit B2    ATPase, H+ transporting, V1 subunit B, isoform 2  Name updated 1299863 APPROVED
2005-01-20 Atp6v1b2  ATPase, H+ transporting, V1 subunit B, isoform 2  Atp6b2  ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 2  Symbol and Name updated 1299863 APPROVED
2002-08-07 Atp6b2  ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference