Atp6v1b2 (ATPase H+ transporting V1 subunit B2)

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Gene: Atp6v1b2 (ATPase H+ transporting V1 subunit B2) Rattus norvegicus

Analyze

Symbol:

Atp6v1b2

Name:

ATPase H+ transporting V1 subunit B2

RGD ID:

620284

Description:

Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in synaptic vesicle lumen acidification and vacuolar acidification. Part of vacuolar proton-transporting V-type ATPase, V1 domain. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in autosomal dominant congenital deafness with onychodystrophy. Orthologous to human ATP6V1B2 (ATPase H+ transporting V1 subunit B2); PARTICIPATES IN oxidative phosphorylation pathway; phagocytosis pathway; rheumatoid arthritis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2,2-tetramine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Atp6b1b2; Atp6b2; ATPase, H transporting, lysosomal V1 subunit B2; ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa; ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 2; ATPase, H+ transporting, V1 subunit B; ATPase, H+ transporting, V1 subunit B, isoform 2; endomembrane proton pump 58 kDa subunit; V-ATPase; V-ATPase subunit B 2; V-type proton ATPase subunit B, brain isoform; vacuolar H+ATPase B2; vacuolar proton pump subunit B 2; Vatb

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ATP6V1B2 (ATPase H+ transporting V1 subunit B2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Atp6v1b2 (ATPase, H+ transporting, lysosomal V1 subunit B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Atp6v1b2 (ATPase H+ transporting V1 subunit B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ATP6V1B2 (ATPase H+ transporting V1 subunit B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ATP6V1B2 (ATPase H+ transporting V1 subunit B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Atp6v1b2 (ATPase H+ transporting V1 subunit B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ATP6V1B2 (ATPase H+ transporting V1 subunit B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ATP6V1B2 (ATPase H+ transporting V1 subunit B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Atp6v1b2 (ATPase H+ transporting V1 subunit B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ATP6V1B1 (ATPase H+ transporting V1 subunit B1)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	ATP6V1B2 (ATPase H+ transporting V1 subunit B2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Atp6v1b2 (ATPase, H+ transporting, lysosomal V1 subunit B2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	atp6v1ba (ATPase, H+ transporting, lysosomal, V1 subunit B, member a)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	atp6v1b2 (ATPase H+ transporting V1 subunit B2)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	VMA2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Vha55	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	spe-5	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	vha-12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cxcr3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	atp6v1b2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	20,617,515 - 20,641,651 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	20,617,518 - 20,641,745 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	23,985,269 - 24,010,794 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	27,416,771 - 27,440,870 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	23,350,578 - 23,376,103 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	22,326,537 - 22,350,143 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	22,326,529 - 22,350,155 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	22,221,011 - 22,244,664 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	22,320,425 - 22,344,445 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	22,320,425 - 22,344,443 (-)	NCBI
Celera	16	20,593,372 - 20,617,306 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant congenital deafness with onychodystrophy (ISO,ISS)

follicular lymphoma (ISO)

genetic disease (ISO)

hereditary spastic paraplegia 53 (ISO)

osteoarthritis (ISO)

Zimmerman Laband Syndrome (ISO)

Zimmermann-Laband Syndrome 1 (ISO)

Zimmermann-Laband Syndrome 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

2,2,2-tetramine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (EXP)

2,4-dinitrotoluene (EXP)

2-amino-14,16-dimethyloctadecan-3-ol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP,ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

antimycin A (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

azoxystrobin (ISO)

benzatropine (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

calcidiol (EXP)

carbon nanotube (EXP,ISO)

chloropicrin (ISO)

chlorpromazine (EXP)

chlorpyrifos (EXP,ISO)

clozapine (EXP,ISO)

cobalt dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

CU-O LINKAGE (ISO)

deguelin (ISO)

deoxynivalenol (ISO)

diethylstilbestrol (EXP,ISO)

endosulfan (EXP)

ethanol (ISO)

fenpyroximate (ISO)

flutamide (EXP)

folic acid (ISO)

genistein (ISO)

gentamycin (EXP)

ginsenoside Rb1 (ISO)

haloperidol (ISO)

indometacin (EXP)

ivermectin (ISO)

lead diacetate (EXP,ISO)

leflunomide (ISO)

methamphetamine (EXP,ISO)

methapyrilene (EXP)

Methylazoxymethanol acetate (EXP)

microcystin-LR (EXP)

nefazodone (EXP)

nickel atom (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

phenobarbital (EXP)

phenylpropanolamine (ISO)

picoxystrobin (ISO)

quartz (EXP)

resveratrol (ISO)

rotenone (EXP,ISO)

sodium arsenite (EXP)

T-2 toxin (EXP)

tebufenpyrad (ISO)

testosterone (EXP)

tetrachloromethane (ISO)

thioacetamide (EXP)

trichostatin A (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc dichloride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ATP metabolic process (IEA)

proton transmembrane transport (IEA)

regulation of cellular pH (TAS)

synaptic vesicle lumen acidification (ISO)

vacuolar acidification (IBA,TAS)

Cellular Component

apical plasma membrane (IEA,ISO,ISS)

clathrin-coated vesicle membrane (IEA)

cytoplasm (IEA,ISO)

cytosol (ISO,ISS)

extrinsic component of synaptic vesicle membrane (EXP,IDA,IEP)

intracellular membrane-bounded organelle (ISO)

melanosome (IEA)

microvillus (ISO)

plasma membrane (ISO,ISS)

proton-transporting V-type ATPase, V1 domain (IEA)

ruffle (ISO)

vacuolar proton-transporting V-type ATPase, V1 domain (IDA,ISO)

Molecular Function

ATP binding (IEA)

protein binding (ISO)

proton-transporting ATPase activity, rotational mechanism (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

oxidative phosphorylation pathway (IEA)

phagocytosis pathway (IEA)

rheumatoid arthritis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Structure of V-ATPase from the mammalian brain.	Abbas YM, etal., Science. 2020 Mar 13;367(6483):1240-1246. doi: 10.1126/science.aaz2924.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis.	Paunescu TG, etal., Am J Physiol Cell Physiol 2004 Jul;287(1):C149-62. Epub 2004 Mar 10.
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Information Derived from GenBank Report	RGD, Sept. 2003

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:16177003	PMID:17392376	PMID:17634366	PMID:17897319	PMID:17898041	PMID:17959750	PMID:18667600	PMID:19056867	PMID:19199708	PMID:19396617
PMID:20169059	PMID:21700703	PMID:22245629	PMID:22467241	PMID:22871113	PMID:23376485	PMID:23533145	PMID:29476059	PMID:31686426	PMID:32357304

Genomics

Comparative Map Data

Atp6v1b2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	20,617,515 - 20,641,651 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	20,617,518 - 20,641,745 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	23,985,269 - 24,010,794 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	27,416,771 - 27,440,870 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	23,350,578 - 23,376,103 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	22,326,537 - 22,350,143 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	22,326,529 - 22,350,155 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	22,221,011 - 22,244,664 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	22,320,425 - 22,344,445 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	22,320,425 - 22,344,443 (-)	NCBI
Celera	16	20,593,372 - 20,617,306 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

ATP6V1B2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	20,197,381 - 20,221,696 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	20,197,381 - 20,226,819 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	20,054,892 - 20,079,207 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	20,098,984 - 20,123,487 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	20,098,983 - 20,123,485	NCBI
Celera	8	19,017,312 - 19,041,815 (+)	NCBI		Celera
Cytogenetic Map	8	p21.3	NCBI
HuRef	8	18,594,885 - 18,619,391 (+)	NCBI		HuRef
CHM1_1	8	20,256,468 - 20,280,970 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	20,462,474 - 20,486,792 (+)	NCBI		T2T-CHM13v2.0

Atp6v1b2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	69,541,388 - 69,566,370 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	69,541,298 - 69,566,363 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	69,088,736 - 69,113,718 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	69,088,646 - 69,113,711 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	71,612,635 - 71,637,617 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	72,017,774 - 72,042,696 (+)	NCBI		MGSCv36	mm8
Celera	8	71,638,588 - 71,664,008 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	33.88	NCBI

Atp6v1b2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	43,860,728 - 43,886,732 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	43,860,811 - 43,886,398 (+)	NCBI	ChiLan1.0	ChiLan1.0

ATP6V1B2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	8	14,404,285 - 14,428,721 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	19,422,423 - 19,446,799 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	16,369,937 - 16,394,284 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	16,369,937 - 16,394,284 (+)	Ensembl	panpan1.1		panPan2

ATP6V1B2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	36,833,246 - 36,858,846 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	36,834,196 - 36,858,819 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	37,427,758 - 37,453,358 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	37,060,323 - 37,085,593 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	37,058,861 - 37,085,557 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	36,996,082 - 37,021,279 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	36,844,258 - 36,869,790 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	37,013,339 - 37,038,613 (-)	NCBI		UU_Cfam_GSD_1.0

Atp6v1b2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	14,261,909 - 14,285,067 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936555	4,285,269 - 4,310,858 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936555	4,285,269 - 4,307,715 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATP6V1B2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	4,289,339 - 4,318,584 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	4,289,257 - 4,318,587 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	4,718,964 - 4,748,253 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATP6V1B2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	18,264,210 - 18,289,951 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	18,264,329 - 18,293,444 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	23,963,087 - 23,988,457 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Atp6v1b2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	15,910,132 - 15,935,160 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	15,910,189 - 15,933,975 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Atp6v1b2
158 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	190
Count of miRNA genes:	128
Interacting mature miRNAs:	158
Transcripts:	ENSRNOT00000015931
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	22477621	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26727669	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26727669	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	26727669	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	30836262	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	32139025	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33418960	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39533930	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39533930	Rat
631561	Hcuc2	Hepatic copper content QTL 2	2.8		liver copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	39533949	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	1	43534949	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1	44588133	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	44977551	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	832236	46053497	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	832236	59492508	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	832236	59492508	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	832236	59492508	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	832236	59492508	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3380150	21361552	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3380150	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4227609	43025077	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4227609	46975965	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	4227609	48972724	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	49227609	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	60252231	Rat
631517	Scl9	Serum cholesterol level QTL 9	3.3		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	16	15726433	21034895	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
70215	Niddm29	Non-insulin dependent diabetes mellitus QTL 29	3.54		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	16	19004435	75226532	Rat

Markers in Region

AI790362

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	20,618,272 - 20,618,362 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	22,327,295 - 22,327,384	NCBI	Rnor6.0
Rnor_5.0	16	22,221,769 - 22,221,858	UniSTS	Rnor5.0
RGSC_v3.4	16	22,321,183 - 22,321,272	UniSTS	RGSC3.4
Celera	16	20,594,130 - 20,594,219	UniSTS
Cytogenetic Map	16	p14	UniSTS

BI279710

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	20,617,897 - 20,618,078 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	22,326,920 - 22,327,100	NCBI	Rnor6.0
Rnor_5.0	16	22,221,394 - 22,221,574	UniSTS	Rnor5.0
RGSC_v3.4	16	22,320,808 - 22,320,988	UniSTS	RGSC3.4
Celera	16	20,593,755 - 20,593,935	UniSTS
Cytogenetic Map	16	p14	UniSTS

AU046373

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	20,638,872 - 20,639,106 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	22,347,365 - 22,347,598	NCBI	Rnor6.0
Rnor_5.0	16	22,241,886 - 22,242,119	UniSTS	Rnor5.0
RGSC_v3.4	16	22,341,667 - 22,341,900	UniSTS	RGSC3.4
Celera	16	20,614,528 - 20,614,761	UniSTS
Cytogenetic Map	16	p14	UniSTS

Atp6b1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	20,627,072 - 20,627,703 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	22,336,095 - 22,336,725	NCBI	Rnor6.0
Rnor_5.0	16	22,230,569 - 22,231,199	UniSTS	Rnor5.0
RGSC_v3.4	16	22,329,983 - 22,330,613	UniSTS	RGSC3.4
Celera	16	20,602,930 - 20,603,560	UniSTS
Cytogenetic Map	16	p14	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_057213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC085714	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232688	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Y12635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000015931 ⟹ ENSRNOP00000015931

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	20,617,521 - 20,641,745 (-)	Ensembl
Rnor_6.0 Ensembl	16	22,326,529 - 22,350,155 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103109 ⟹ ENSRNOP00000090370

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	20,617,518 - 20,634,929 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000104552 ⟹ ENSRNOP00000090567

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	20,617,518 - 20,641,638 (-)	Ensembl

RefSeq Acc Id:

NM_057213 ⟹ NP_476561

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	20,617,515 - 20,641,651 (-)	NCBI
Rnor_6.0	16	22,326,537 - 22,350,143 (-)	NCBI
Rnor_5.0	16	22,221,011 - 22,244,664 (-)	NCBI
RGSC_v3.4	16	22,320,425 - 22,344,445 (-)	RGD
Celera	16	20,593,372 - 20,617,306 (-)	RGD

Sequence:

show sequence

CGGAGGAGACAAGATGGCGTTGCGAGCGATGCGGGGAATCGTGAACGGGGCCGCGCCCGAGCTG
CCCGTGCCCACCGGTGGGCCGATGGCCGGAGCTCGGGAGCAGGCGCTGGCGGTGAGCCGGAACT
ACCTCTCCCAGCCTCGTCTCACCTACAAGACTGTCTCTGGAGTGAATGGTCCACTAGTGATCTT
AGATCATGTAAAGTTTCCCAGATATGCTGAGATTGTCCACTTGACATTACCAGATGGCACAAAA
AGAAGTGGGCAAGTTCTAGAAGTTAGTGGCTCCAAAGCCGTGGTTCAGGTATTTGAAGGAACAT
CCGGCATAGATGCCAAGAAAACATCCTGTGAGTTTACTGGAGATATTCTCCGCACACCAGTGTC
TGAGGATATGCTTGGTCGAGTATTCAATGGATCAGGAAAACCCATTGACCGAGGTCCTGTGGTG
TTGGCCGAAGACTTCCTTGACATCATGGGTCAGCCAATCAACCCTCAGTGTCGCATCTACCCAG
AAGAGATGATTCAGACGGGCATTTCTGCCATCGATGGCATGAACAGTATTGCGAGGGGACAGAA
AATCCCCATCTTTTCTGCTGCCGGGTTACCACACAACGAGATTGCAGCTCAGATCTGTCGCCAG
GCTGGTTTGGTAAAGAAATCCAAAGACGTGGTAGACTACAGTGAAGAAAACTTTGCCATTGTGT
TTGCTGCTATGGGAGTAAACATGGAAACAGCCCGGTTCTTCAAATCTGACTTTGAAGAAAATGG
CTCAATGGACAATGTCTGCCTTTTCTTGAATCTGGCTAATGACCCAACTATCGAGAGGATCATC
ACTCCTCGCCTGGCTCTGACCACCGCTGAGTTTCTGGCTTACCAGTGTGAGAAGCATGTCCTGG
TCATCCTGACAGATATGAGTTCTTACGCTGAAGCACTTCGAGAGGTTTCAGCTGCCAGGGAAGA
GGTTCCTGGTCGGCGAGGCTTCCCCGGCTACATGTATACGGATTTAGCCACCATCTATGAACGC
GCTGGGCGAGTGGAAGGTAGAAATGGCTCTATTACCCAAATCCCTATTCTCACCATGCCCAATG
ATGATATCACTCATCCTATCCCTGACTTGACTGGGTATATTACTGAGGGCCAGATCTATGTGGA
CAGACAGCTGCACAACAGACAGATTTACCCTCCTATTAATGTGCTGCCCTCACTCTCTCGGTTA
ATGAAGTCAGCTATTGGAGAAGGAATGACCAGGAAGGATCATGCTGATGTGTCTAACCAGTTGT
ACGCATGCTATGCTATCGGTAAGGATGTGCAAGCCATGAAAGCTGTGGTGGGAGAAGAAGCCCT
GACCTCAGATGACCTCCTTTACTTGGAATTTCTGCAGAAGTTTGAGAAAAACTTCATTACTCAG
GGTCCCTATGAAAATCGAACTGTCTATGAGACTTTGGACATTGGCTGGCAGTTGCTTCGAATCT
TCCCCAAAGAAATGCTGAAGAGGATCCCTCAGAGTACCCTGAGCGAATTTTACCCTCGAGACTC
TGCAAAGCACTAGCTGCTGCTGCTTGTGCGGCTCGACCCTCTTGTGAAGTGCTGGTTCTGTTTG
CTGATTCCTTTTGCACTCCTCCATCCCACCTGTGTGTGGGAGTTCACCTGTTACCCTGTAATTA
AAGACAAAGGCTAGGTAACTGTTGTGCCAGTGTTCAGCGTTTAAACTGCTAACCGATTGAGAGA
TCCCCGCTCAGAACCTCACCTTCTGTGCTGTCTTTAAAGTGGCGGAGGTGAGGCTTGCTTACCG
GTGTATCTATTTGTACATAGTGGAGAGCTAGTTGCGAATAATGTCTTGTTTGGGTCTCCCAAAC
CCTACCTCTCAACTCCCTTAAGAGTATCACTGTTTTGAAGTTAAAATGCTTCAGTCTCAAATTT
AGGGGCAAGGTGGAGACTGGAAGAATTCTCCTTTCAGAAGAACCATGAGGCTCGTGGCTGAGCC
TCCCTCTGGAGTACTAGTGTACCTGTGGGTCTGTCCTCTGCTCTGTGCAGATGGGTTTTACTGT
CTGCTTGAGTTTTCTTAGGAAAAGAGTTCTGTTCTGCCAGTGCTGCGAGTTGGGATTCCTGTGT
GGCCATCTTTCTCTTTGAGGCCTAAAGAGTCAGGCACCACTGTGCAGCGGCATTCTCCTGCAGG
GGTGGCGTGCCTTGTGCTGATGACCCCCACTGGGCTGCAGTCATAGGAGAACTGAGACTTGGAA
AATGCTGGGGCACAGTTAAGAAAACCTACATCCCACCCTCATCTTGTGTTTATGGTGGCTTAGG
TCTCTGCATTGCCCTCCAGATCCTGAGGTGGGGCATGGAGATGACTTGCCTTAGGTTTGTGGAT
GCTTTAAACTCTGCTCAGTCCTCAAGCTTTCTGACTCAGCTCTCCCTTTTCTGGGTGATCTTGT
GGCACGTGTAGCAATGTTTCTTTCATTCCTGTCCCTTCCTGGCTTGAGCTCTTAGCTGTATTCT
GTGTGCCTCTGCCGTGTCTGCTGTTTGGGTCTCTGTGCTGTGTGTTCTCAGGTGCAGCCATAAC
TTCCCCACTCCGAGCATTCCACCTTCCAGTTGTTTTTCTCTGAGGGGATGGGGGGGCGGTCAGC
ATGATTATATTTTAATGTAGAAAATGTGACATCTCGTTATAAATGAAAATAAATGTTAAATTAA
ATGGAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_476561	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85714	(Get FASTA)	NCBI Sequence Viewer
	CAA73183	(Get FASTA)	NCBI Sequence Viewer
	EDL84666	(Get FASTA)	NCBI Sequence Viewer
	EDL84667	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015931
	ENSRNOP00000090370.1
	ENSRNOP00000090567.1
GenBank Protein	P62815	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_476561 ⟸ NM_057213

- UniProtKB:

P62815 (UniProtKB/Swiss-Prot), A6KU69 (UniProtKB/TrEMBL), A0A8I6ADT2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MALRAMRGIVNGAAPELPVPTGGPMAGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVK
FPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDML
GRVFNGSGKPIDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIF
SAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDN
VCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGR
RGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLH
NRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDD
LLYLEFLQKFEKNFITQGPYENRTVYETLDIGWQLLRIFPKEMLKRIPQSTLSEFYPRDSAKH

hide sequence

RefSeq Acc Id:

ENSRNOP00000015931 ⟸ ENSRNOT00000015931

RefSeq Acc Id:

ENSRNOP00000090370 ⟸ ENSRNOT00000103109

RefSeq Acc Id:

ENSRNOP00000090567 ⟸ ENSRNOT00000104552

Protein Domains

ATPase F1/V1/A1 complex alpha/beta subunit ATPase F1/V1/A1 complex alpha/beta subunit N-

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P62815-F1-model_v2	AlphaFold	P62815	1-511	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700056

Promoter ID:

EPDNEW_R10580

Type:

multiple initiation site

Name:

Atp6v1b2_1

Description:

ATPase H+ transporting V1 subunit B2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	22,350,154 - 22,350,214	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620284	AgrOrtholog
BioCyc Gene	G2FUF-11703	BioCyc
BioCyc Pathway	PWY-7980 [ATP biosynthesis]	BioCyc
Ensembl Genes	ENSRNOG00000011891	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000015931	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000103109.1	UniProtKB/TrEMBL
	ENSRNOT00000104552.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.12240	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7109340	IMAGE-MGC_LOAD
InterPro	ATPase_a/bsu_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATPase_F1/V1/A1_a/bsu_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATPase_F1/V1/A1_a/bsu_nucl-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATPase_V1-cplx_bsu	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	V-ATPase_su_B/beta	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:117596	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93249	IMAGE-MGC_LOAD
NCBI Gene	117596	ENTREZGENE
PANTHER	PTHR43389	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	V-TYPE PROTON ATPASE SUBUNIT B, BRAIN ISOFORM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	ATP-synt_ab	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP-synt_ab_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Atp6v1b2	PhenoGen
PIRSF	V-ATPsynth_beta/V-ATPase_B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ATPASE_ALPHA_BETA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011891	RatGTEx
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6ADT2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AE86_RAT	UniProtKB/TrEMBL
	A6KU69	ENTREZGENE, UniProtKB/TrEMBL
	A6KU70_RAT	UniProtKB/TrEMBL
	P62815	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	O09045	UniProtKB/Swiss-Prot
	P50517	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-25	Atp6v1b2	ATPase H+ transporting V1 subunit B2	Atp6v1b2	ATPase, H transporting, lysosomal V1 subunit B2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Atp6v1b2	ATPase, H transporting, lysosomal V1 subunit B2		ATPase, H+ transporting, V1 subunit B, isoform 2	Name updated	1299863	APPROVED
2005-01-20	Atp6v1b2	ATPase, H+ transporting, V1 subunit B, isoform 2	Atp6b2	ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 2	Symbol and Name updated	1299863	APPROVED
2002-08-07	Atp6b2	ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)