phenothiazines - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	phenothiazines	go back to main search page
Accession:	CHEBI:38093	browse the term
Synonyms:	xref_mesh:	MESH:D010640

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Rat (365) Mouse (364) Human (370) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (2) Green Monkey (0) Naked Mole-rat (0) All
Genes (365)

phenothiazines

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

increases activity
multiple interactions

Phenothiazines analog results in increased activity of ABCC1 protein
Phenothiazines analog promotes the reaction [ABCC1 protein results in increased secretion of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

butyrylcholinesterase

decreases activity

Phenothiazines results in decreased activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

1-[10-[3-[4-(2-hydroxyethyl)-1-piperidinyl]propyl]-2-phenothiazinyl]ethanone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

piperacetazine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

10-(beta-Dimethylaminopropionyl)phenothiazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hepcidin antimicrobial peptide

decreases expression

10-(alpha-diethylaminopropionyl)phenothiazine results in decreased expression of HAMP mRNA

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

10H-phenothiazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

affects localization
multiple interactions

phenothiazine analog affects the localization of AR protein
phenothiazine analog binds to and results in decreased activity of AR protein; phenothiazine inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]

PMID:17606915 PMID:33049310

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

bromodomain containing 4

multiple interactions

phenothiazine inhibits the reaction [BRD4 protein binds to MED1 protein]

NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539

G

estrogen receptor 1

multiple interactions

phenothiazine binds to and results in increased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

phenothiazine binds to and results in increased activity of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

potassium voltage-gated channel subfamily H member 2

decreases activity

phenothiazine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

kallikrein 1-related peptidase C10

multiple interactions

phenothiazine analog affects the reaction [Dihydrotestosterone results in increased expression of KLK3 protein]

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

mediator complex subunit 1

multiple interactions

phenothiazine inhibits the reaction [BRD4 protein binds to MED1 protein]

NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

phenothiazine binds to and results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

peroxisome proliferator-activated receptor gamma

multiple interactions

phenothiazine binds to and results in increased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

acepromazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

increases activity

Acepromazine results in increased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

acetophenazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

acetophenazine binds to and results in decreased activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

chlorpromazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases expression

[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCB11 mRNA
Chlorpromazine results in decreased expression of ABCB11 mRNA; Chlorpromazine results in decreased expression of ABCB11 protein

PMID:27344345 PMID:27765674 PMID:28391356 PMID:35708773

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

increases expression
decreases activity

Chlorpromazine analog results in increased expression of ABCB1 mRNA
Chlorpromazine results in decreased activity of ABCB1 protein

PMID:15924885 PMID:16810505

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

affects activity

Chlorpromazine affects the activity of ABCB1B protein

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily B member 4

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCB4 mRNA

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily B member 6

decreases expression

Chlorpromazine results in decreased expression of ABCB6 mRNA

NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924

G

ATP binding cassette subfamily B member 9

increases expression

Chlorpromazine results in increased expression of ABCB9 mRNA

NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931

G

ATP binding cassette subfamily C member 2

increases expression
multiple interactions

Chlorpromazine results in increased expression of ABCC2 mRNA
[Bile Acids and Salts co-treated with Chlorpromazine] results in decreased expression of ABCC2 mRNA

PMID:27765674 PMID:35708773

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

increases expression
multiple interactions
decreases expression

Chlorpromazine analog results in increased expression of ABCC3 mRNA
[Bile Acids and Salts co-treated with Chlorpromazine] results in decreased expression of ABCC3 mRNA
Chlorpromazine results in decreased expression of ABCC3 mRNA

PMID:15924885 PMID:25596134 PMID:35708773

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

increases expression

Chlorpromazine results in increased expression of ABCC4 mRNA

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily G member 2

multiple interactions

Chlorpromazine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ATP binding cassette subfamily G member 8

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCG8 mRNA

NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912

G

acetyl-CoA carboxylase alpha

decreases phosphorylation

Chlorpromazine results in decreased phosphorylation of ACACA protein

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

angiotensin converting enzyme 2

decreases expression

Chlorpromazine results in decreased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acetylcholinesterase

decreases activity
increases activity
multiple interactions

Chlorpromazine results in decreased activity of ACHE protein
Chlorpromazine results in increased activity of ACHE protein
Dichlorvos promotes the reaction [Chlorpromazine results in decreased activity of ACHE protein]

PMID:4859365 PMID:29614332

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

acid phosphatase 5, tartrate resistant

multiple interactions

Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

adrenoceptor alpha 1A

decreases activity

Chlorpromazine results in decreased activity of ADRA1A protein

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

adrenoceptor alpha 1B

decreases activity

Chlorpromazine results in decreased activity of ADRA1B protein

NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919

G

alpha-fetoprotein

decreases expression

Chlorpromazine analog results in decreased expression of AFP mRNA

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

agrin

decreases expression

Chlorpromazine results in decreased expression of AGRN mRNA

NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003

G

aryl hydrocarbon receptor

affects activity

Chlorpromazine affects the activity of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

adenylate kinase 3

decreases expression

Chlorpromazine results in decreased expression of AK3 mRNA

NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625

G

AKT serine/threonine kinase 1

decreases phosphorylation

Chlorpromazine results in decreased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 1 family, member A1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldolase, fructose-bisphosphate A

increases expression

Chlorpromazine results in increased expression of ALDOA mRNA

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

alkaline phosphatase, placental

multiple interactions

Chlorpromazine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Chlorpromazine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]

NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

Chlorpromazine results in decreased expression of AP1S1 mRNA

NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713

G

apolipoprotein C4

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of APOC4 mRNA

NCBI chr 1:79,335,745...79,339,942
Ensembl chr 1:79,335,745...79,339,981

G

apolipoprotein F

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of APOF mRNA

NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946

G

amphiregulin

decreases expression

Chlorpromazine results in decreased expression of AREG mRNA

PMID:15924885 PMID:30703373

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

ADP ribosylation factor guanine nucleotide exchange factor 2

increases expression

Chlorpromazine results in increased expression of ARFGEF2 mRNA

NCBI chr 3:155,547,504...155,633,652
Ensembl chr 3:155,547,538...155,630,856

G

Rho guanine nucleotide exchange factor 10

decreases expression

Chlorpromazine results in decreased expression of ARHGEF10 mRNA

NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173

G

N-acylsphingosine amidohydrolase 1

increases expression

Chlorpromazine results in increased expression of ASAH1 mRNA

NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

Chlorpromazine results in increased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

activating transcription factor 4

affects activity
multiple interactions

Chlorpromazine affects the activity of ATF4 protein
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ATF4 mRNA

PMID:25596134 PMID:27344345

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

ATPase H+ transporting V1 subunit B2

decreases expression

Chlorpromazine results in decreased expression of ATP6V1B2 protein

NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745

G

arginine vasopressin

increases expression
multiple interactions

Chlorpromazine results in increased expression of AVP protein
Chlorpromazine inhibits the reaction [Lithium results in increased expression of AVP protein]

PMID:3567260 PMID:3976404

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

BAG cochaperone 4

decreases expression

Chlorpromazine analog results in decreased expression of BAG4 mRNA

NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663

G

Bcl2-like 1

increases expression

Chlorpromazine results in increased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

brain-derived neurotrophic factor

affects response to substance
affects expression

BDNF affects the susceptibility to Chlorpromazine
Chlorpromazine affects the expression of BDNF mRNA

PMID:18408624 PMID:31324950

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

basic helix-loop-helix family, member e40

increases expression

Chlorpromazine analog results in increased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

baculoviral IAP repeat-containing 2

decreases expression

Chlorpromazine results in decreased expression of BIRC2 mRNA

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 5

decreases expression

Chlorpromazine analog results in decreased expression of BIRC5 mRNA; Chlorpromazine results in decreased expression of BIRC5 mRNA

PMID:15924885 PMID:30703373

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

BCL2 interacting protein 3

increases expression

Chlorpromazine results in increased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BTG anti-proliferation factor 2

increases expression

Chlorpromazine analog results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

BTG anti-proliferation factor 3

increases expression

Chlorpromazine analog results in increased expression of BTG3 mRNA

NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170

G

complement C3

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of C3 mRNA

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C6

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of C6 mRNA

NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275

G

calcitonin receptor

multiple interactions

Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]

NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392

G

calreticulin

decreases expression

Chlorpromazine results in decreased expression of CALR mRNA

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

carbonic anhydrase 2

multiple interactions

Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

catalase

multiple interactions
decreases expression
decreases activity

carvedilol inhibits the reaction [Chlorpromazine results in decreased expression of CAT protein]; zolpidem inhibits the reaction [Chlorpromazine results in decreased activity of CAT]

PMID:12010767 PMID:17513028 PMID:25449126

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cellular communication network factor 2

decreases expression

Chlorpromazine results in decreased expression of CCN2 mRNA; Chlorpromazine results in decreased expression of CCN2 protein

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cellular communication network factor 3

affects expression

Chlorpromazine affects the expression of CCN3 mRNA

NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019

G

cyclin B2

decreases expression

Chlorpromazine analog results in decreased expression of CCNB2 mRNA; Chlorpromazine results in decreased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

decreases expression

Chlorpromazine results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D3

decreases expression

Chlorpromazine analog results in decreased expression of CCND3 mRNA

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin F

decreases expression

Chlorpromazine analog results in decreased expression of CCNF mRNA

NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101

G

CD274 molecule

multiple interactions

Chlorpromazine inhibits the reaction [platycodin D results in decreased expression of and results in increased secretion of CD274 protein]

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

G

CD44 molecule

multiple interactions
decreases expression

Chlorpromazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD44 protein]
Chlorpromazine results in decreased expression of CD44 protein

PMID:9929743 PMID:30703373

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

CD86 molecule

increases expression

Chlorpromazine results in increased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cyclin-dependent kinase 5

decreases expression

Chlorpromazine analog results in decreased expression of CDK5 mRNA

NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112

G

cyclin-dependent kinase 7

increases expression

Chlorpromazine analog results in increased expression of CDK7 mRNA

NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

[EGR1 binds to CDKN1A promoter] promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; EGR1 promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2C

decreases expression

Chlorpromazine analog results in decreased expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

carboxylesterase 2H

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of CES2 mRNA

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

complement factor H

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of CFH mRNA

NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838

G

cell growth regulator with EF hand domain 1

decreases expression

Chlorpromazine results in decreased expression of CGREF1 mRNA

NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852

G

chromosome transmission fidelity factor 18

decreases expression

Chlorpromazine analog results in decreased expression of CHTF18 mRNA

NCBI chr10:14,743,006...14,751,044
Ensembl chr10:14,742,621...14,751,050

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

decreases expression

Chlorpromazine results in decreased expression of CITED2 mRNA

NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897

G

CDC28 protein kinase regulatory subunit 2

decreases expression

Chlorpromazine analog results in decreased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

cardiotrophin-like cytokine factor 1

increases expression

Chlorpromazine results in increased expression of CLCF1 mRNA

NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605

G

collagen type XVIII alpha 1 chain

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of COL18A1 mRNA

NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593

G

collagen type I alpha 1 chain

increases expression

Chlorpromazine results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type IV alpha 1 chain

decreases expression

Chlorpromazine results in decreased expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

cortistatin

affects expression

Chlorpromazine affects the expression of CORT mRNA

NCBI chr 5:159,560,591...159,562,032

G

cytochrome c oxidase subunit 8A

affects expression
increases expression

Chlorpromazine affects the expression of COX8A mRNA
Chlorpromazine results in increased expression of COX8A mRNA

NCBI chr 1:204,402,118...204,404,439

G

corticotropin releasing hormone

decreases expression

Chlorpromazine results in decreased expression of CRH mRNA

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

cystathionine gamma-lyase

decreases expression

Chlorpromazine results in decreased expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

cathepsin K

multiple interactions

Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
decreases response to substance
increases expression

[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Chlorpromazine results in decreased activity of CYP1A1 protein
CYP1A1 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in increased expression of CYP1A1 mRNA

PMID:17202759 PMID:18246545 PMID:18493746 PMID:25596134 PMID:26477383 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases response to substance
increases expression
increases oxidation
affects expression
decreases methylation

[Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP1A2 mRNA; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; CYP1A2 protein results in increased metabolism of and results in increased activity of Chlorpromazine
CYP1A2 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in increased expression of CYP1A2 mRNA
CYP1A2 protein results in increased oxidation of Chlorpromazine
Chlorpromazine affects the expression of CYP1A2 mRNA
CYP1A2 protein results in decreased methylation of Chlorpromazine

PMID:18246545 PMID:18493746 PMID:19482014 PMID:20615392 PMID:23397584 More...

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases response to substance
decreases activity
multiple interactions

CYP1B1 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in decreased activity of CYP1B1 protein
[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA]

PMID:26477383 PMID:29724254 PMID:33814510

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
decreases response to substance

[Chlorpromazine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Chlorpromazine inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]]
NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP2B10 mRNA]
CYP2B6 protein results in decreased susceptibility to Chlorpromazine

PMID:10037683 PMID:12049174 PMID:17041008 PMID:26477383

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

decreases expression
decreases response to substance

Chlorpromazine results in decreased expression of CYP2C mRNA; Chlorpromazine results in decreased expression of CYP2C11 mRNA
CYP2C18 protein results in decreased susceptibility to Chlorpromazine

PMID:18246545 PMID:26477383

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
decreases response to substance
decreases activity
affects methylation

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine
CYP2C19 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in decreased activity of CYP2C19 protein
CYP2C19 protein affects the methylation of Chlorpromazine

PMID:15135088 PMID:20615392 PMID:23397584 PMID:26477383

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases response to substance

CYP2C8 protein results in decreased susceptibility to Chlorpromazine

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
decreases response to substance

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; CYP2D6 protein results in increased metabolism of and results in increased activity of Chlorpromazine
CYP2D6 protein results in decreased susceptibility to Chlorpromazine

PMID:19482014 PMID:23397584 PMID:26477383

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity
decreases response to substance

Chlorpromazine results in decreased activity of CYP2E1 protein
CYP2E1 protein results in decreased susceptibility to Chlorpromazine

PMID:15135088 PMID:26477383

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects methylation
affects oxidation
multiple interactions
decreases response to substance
decreases activity

CYP3A4 protein affects the methylation of Chlorpromazine
CYP3A4 protein affects the oxidation of Chlorpromazine
[Chlorpromazine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine
CYP3A4 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in decreased activity of CYP3A4 protein

PMID:15135088 PMID:17041008 PMID:20615392 PMID:23397584 PMID:26477383

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

decreases response to substance

CYP3A5 protein results in decreased susceptibility to Chlorpromazine

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450 family 8 subfamily B member 1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP8B1 mRNA

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

D-amino-acid oxidase

decreases activity

Chlorpromazine results in decreased activity of DAO protein

NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741

G

dendrocyte expressed seven transmembrane protein

multiple interactions

Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]

NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078

G

DNA-damage inducible transcript 3

increases expression

Chlorpromazine results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEPP autophagy regulator 1

increases expression

Chlorpromazine results in increased expression of DEPP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

dopamine receptor D1

decreases activity

Chlorpromazine results in decreased activity of DRD1 protein

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

decreases response to substance
decreases activity

DRD2 polymorphism results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in decreased activity of DRD2 protein

PMID:15694263 PMID:23611293

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dual specificity phosphatase 1

increases expression
affects expression

Chlorpromazine analog results in increased expression of DUSP1 mRNA
Chlorpromazine affects the expression of DUSP1 mRNA

PMID:15924885 PMID:20843724

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 9

decreases expression

Chlorpromazine analog results in decreased expression of DUSP9 mRNA

NCBI chr X:151,351,897...151,355,822
Ensembl chr X:151,351,897...151,355,821

G

E2F transcription factor 1

decreases expression

Chlorpromazine analog results in decreased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

early growth response 1

increases expression
multiple interactions

Chlorpromazine results in increased expression of EGR1
[EGR1 binds to CDKN1A promoter] promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; EGR1 promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; MAPK1 affects the reaction [Chlorpromazine results in increased expression of EGR1]; MAPK3 affects the reaction [Chlorpromazine results in increased expression of EGR1]

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 1

increases expression

Chlorpromazine results in increased expression of EIF1 mRNA

NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327

G

enolase 2

increases expression

Chlorpromazine results in increased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

Chlorpromazine results in increased expression of ERO1A mRNA

NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478

G

coagulation factor II, thrombin

decreases expression

Chlorpromazine analog results in decreased expression of F2 mRNA

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

fatty acid binding protein 1

increases expression

Chlorpromazine results in increased expression of FABP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

Fas cell surface death receptor

increases expression

Chlorpromazine analog results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fructose-bisphosphatase 1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of FBP1 mRNA

NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071

G

F-box protein 22

decreases expression

Chlorpromazine results in decreased expression of FBXO22 mRNA

NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148

G

ferrochelatase

decreases expression

Chlorpromazine results in decreased expression of FECH mRNA

NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348

G

fetuin B

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of FETUB mRNA

NCBI chr11:78,082,158...78,093,022
Ensembl chr11:78,082,156...78,095,135

G

fibrinogen alpha chain

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of FGA mRNA

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fibroblast growth factor 2

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

Fibroblast growth factor receptor 1

decreases expression

Chlorpromazine analog results in decreased expression of FGFR1 mRNA

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

FGR proto-oncogene, Src family tyrosine kinase

decreases expression

Chlorpromazine results in decreased expression of FGR mRNA

NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326

G

FKBP prolyl isomerase 5

multiple interactions

Chlorpromazine inhibits the reaction [Lipopolysaccharides results in decreased expression of FKBP5 protein]

NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674

G

fibronectin type III domain containing 4

increases expression

Chlorpromazine results in increased expression of FNDC4 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675

G

Fos proto-oncogene, AP-1 transcription factor subunit

affects expression

Chlorpromazine affects the expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

affects expression

Chlorpromazine affects the expression of FOSB mRNA

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

FOS like 1, AP-1 transcription factor subunit

increases expression
affects expression

Chlorpromazine analog results in increased expression of FOSL1 mRNA
Chlorpromazine affects the expression of FOSL1 mRNA

PMID:15924885 PMID:20843724

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

FOS like 2, AP-1 transcription factor subunit

affects expression

Chlorpromazine affects the expression of FOSL2 mRNA

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

G

ferritin heavy chain 1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of FTH1 mRNA

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

glucose-6-phosphate dehydrogenase

decreases expression
decreases activity
multiple interactions

Chlorpromazine analog results in decreased expression of G6PD mRNA
Chlorpromazine results in decreased activity of G6PD protein
[Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; Taurine inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]

PMID:15924885 PMID:33548410

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

glutamate decarboxylase 1

decreases methylation
multiple interactions

Chlorpromazine results in decreased methylation of GAD1 promoter
Valproic Acid promotes the reaction [Chlorpromazine results in decreased methylation of GAD1 promoter]

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

glucagon receptor

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of GCGR mRNA

NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640

G

glutamate-cysteine ligase, catalytic subunit

decreases expression

Chlorpromazine results in decreased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

growth differentiation factor 15

increases expression

Chlorpromazine results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glycerophosphodiester phosphodiesterase domain containing 3

increases expression

Chlorpromazine results in increased expression of GDPD3 mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063

G

glial fibrillary acidic protein

affects expression

Chlorpromazine affects the expression of GFAP mRNA

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

glycoprotein nmb

increases expression

Chlorpromazine results in increased expression of GPNMB mRNA

NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367

G

glutamic--pyruvic transaminase

increases expression

Chlorpromazine results in increased expression of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione-disulfide reductase

decreases activity

Chlorpromazine results in decreased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of GSTA1 mRNA

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

hypoxia inducible factor 1 subunit alpha

affects activity

Chlorpromazine affects the activity of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression

Chlorpromazine results in increased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

Chlorpromazine results in increased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

heme oxygenase 1

increases expression
affects expression

Chlorpromazine results in increased expression of HMOX1 mRNA
Chlorpromazine affects the expression of HMOX1 mRNA

PMID:15924885 PMID:25596134 PMID:31324950

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hepsin

increases expression

Chlorpromazine results in increased expression of HPN mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811

G

heat shock protein family A (Hsp70) member 2

increases expression
decreases expression

Chlorpromazine results in increased expression of HSPA2 mRNA
Chlorpromazine results in decreased expression of HSPA2 mRNA; Chlorpromazine results in decreased expression of HSPA2 protein

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family B (small) member 1

increases expression
decreases expression

Chlorpromazine results in increased expression of HSPB1 mRNA
Chlorpromazine results in decreased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family D (Hsp60) member 1

increases expression

Chlorpromazine results in increased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family E (Hsp10) member 1

increases expression

Chlorpromazine results in increased expression of HSPE1 mRNA

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

integrin-binding sialoprotein

decreases expression
multiple interactions

Chlorpromazine results in decreased expression of IBSP mRNA
herbimycin inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA]; U 0126 inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA]

NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693

G

interferon beta 1

multiple interactions

Chlorpromazine promotes the reaction [PAM2-CSK4 results in increased expression of IFNB1 mRNA]

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

interferon gamma

multiple interactions

[Chlorpromazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon, lambda receptor 1

increases expression

Chlorpromazine results in increased expression of IFNLR1 mRNA

NCBI chr 5:147,919,547...147,942,328
Ensembl chr 5:147,919,908...147,942,332

G

insulin-like growth factor binding protein 1

increases expression

Chlorpromazine results in increased expression of IGFBP1 mRNA

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

increases expression

Chlorpromazine analog results in increased expression of IKBKG mRNA

NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499

G

interleukin 1 alpha

multiple interactions

[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

decreases expression

Chlorpromazine results in decreased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

multiple interactions

[Chlorpromazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]; Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]

PMID:11014349 PMID:29594315

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 6

multiple interactions

[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibin subunit beta E

increases expression

Chlorpromazine results in increased expression of INHBE mRNA

PMID:15342952 PMID:17175557

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

insulin 1

decreases secretion

Chlorpromazine results in decreased secretion of INS1 protein

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin induced gene 2

decreases expression

Chlorpromazine results in decreased expression of INSIG2 mRNA

NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923

G

insulin receptor substrate 2

multiple interactions

Chlorpromazine results in decreased expression of and results in decreased phosphorylation of IRS2 protein; Chlorpromazine results in decreased expression of and results in increased degradation of IRS2 protein

PMID:17512020 PMID:18308779

NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

Chlorpromazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Chlorpromazine results in decreased activity of KCNH2 protein

PMID:15071359 PMID:21158687 PMID:24052561

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium calcium-activated channel subfamily N member 2

decreases activity

Chlorpromazine results in decreased activity of KCNN2 protein

NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347

G

KLF transcription factor 4

multiple interactions
decreases expression

[Chlorpromazine co-treated with Cholic Acids] affects the expression of KLF4 mRNA
Chlorpromazine results in decreased expression of KLF4 mRNA

PMID:27344345 PMID:30703373

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

kallikrein B1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of KLKB1 mRNA

NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053

G

kininogen 1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of KNG1 mRNA

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

large tumor suppressor kinase 1

increases phosphorylation

Chlorpromazine results in increased phosphorylation of LATS1 protein

NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640

G

lactate dehydrogenase C

decreases activity
multiple interactions

Chlorpromazine results in decreased activity of LDHC protein
[Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; Taurine inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]

NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378

G

low density lipoprotein receptor

increases expression

Chlorpromazine results in increased expression of LDLR mRNA

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

leptin

increases expression

Chlorpromazine results in increased expression of LEP protein

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

lanosterol synthase

increases expression

Chlorpromazine results in increased expression of LSS mRNA

PMID:15342952 PMID:17175557

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

microtubule-associated protein 2

increases expression

Chlorpromazine results in increased expression of MAP2 mRNA

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase 1

multiple interactions

Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]
MAPK1 affects the reaction [Chlorpromazine results in increased expression of EGR1]

PMID:11014349 PMID:20368687

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

decreases expression

Chlorpromazine analog results in decreased expression of MAPK14 mRNA

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

decreases expression
multiple interactions

Chlorpromazine analog results in decreased expression of MAPK3 mRNA
MAPK3 affects the reaction [Chlorpromazine results in increased expression of EGR1]
Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]

PMID:11014349 PMID:15924885 PMID:20368687

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein; Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

MAPK activated protein kinase 2

increases expression

Chlorpromazine results in increased expression of MAPKAPK2 mRNA

NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457

G

minichromosome maintenance complex component 3

decreases expression

Chlorpromazine analog results in decreased expression of MCM3 mRNA

NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314

G

minichromosome maintenance complex component 5

decreases expression

Chlorpromazine analog results in decreased expression of MCM5 mRNA

NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389

G

MDM2 proto-oncogene

increases expression

Chlorpromazine results in increased expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

melanocyte inducing transcription factor

increases expression

Chlorpromazine results in increased expression of MITF protein

NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145

G

marker of proliferation Ki-67

decreases expression

Chlorpromazine analog results in decreased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 9

multiple interactions

Chlorpromazine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]; Chlorpromazine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

musculin

decreases expression

Chlorpromazine results in decreased expression of MSC mRNA

NCBI chr 5:4,547,335...4,553,206
Ensembl chr 5:4,547,405...4,553,203

G

mutS homolog 2

decreases expression

Chlorpromazine results in decreased expression of MSH2 mRNA

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

macrophage stimulating 1

increases phosphorylation

Chlorpromazine results in increased phosphorylation of MST1 protein

NCBI chr 8:108,767,886...108,773,425
Ensembl chr 8:108,768,839...108,773,416

G

metallothionein 1

increases expression

Chlorpromazine results in increased expression of MT1A mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

G

MYB proto-oncogene like 2

decreases expression

Chlorpromazine analog results in decreased expression of MYBL2 mRNA

NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

Chlorpromazine results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

nicotinamide phosphoribosyltransferase

increases expression

Chlorpromazine results in increased expression of NAMPT mRNA

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

Nanog homeobox

decreases expression

Chlorpromazine results in decreased expression of NANOG mRNA

NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116

G

NADH:ubiquinone oxidoreductase core subunit S3

decreases expression

Chlorpromazine results in decreased expression of NDUFS3 protein

NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824

G

nectin cell adhesion molecule 2

multiple interactions

Chlorpromazine inhibits the reaction [Cadmium Chloride results in decreased expression of and affects the localization of NECTIN2 protein]

NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360

G

neural precursor cell expressed, developmentally down-regulated 9

decreases expression

Chlorpromazine results in decreased expression of NEDD9 mRNA

NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019

G

neurofilament heavy chain

affects expression

Chlorpromazine affects the expression of NEFH mRNA

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

nuclear factor of activated T-cells 1

multiple interactions

Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

NFE2 like bZIP transcription factor 2

decreases expression
affects activity

Chlorpromazine results in decreased expression of NFE2L2 mRNA
Chlorpromazine affects the activity of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

ninjurin 1

increases expression

Chlorpromazine results in increased expression of NINJ1 mRNA

NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704

G

natriuretic peptide B

increases expression

Chlorpromazine results in increased expression of NPPB protein

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

nuclear receptor subfamily 0, group B, member 2

increases expression

Chlorpromazine results in increased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group H, member 4

decreases expression

Chlorpromazine results in decreased expression of NR1H4 mRNA

PMID:27765674 PMID:28391356

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

nuclear receptor subfamily 1, group I, member 2

increases expression
multiple interactions

Chlorpromazine analog results in increased expression of NR1I2 mRNA
[Chlorpromazine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

PMID:15924885 PMID:17041008

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

increases activity
increases expression
multiple interactions

Chlorpromazine results in increased activity of NR1I3 protein
Chlorpromazine results in increased expression of NR1I3 mRNA
[Chlorpromazine co-treated with Cholic Acids] affects the expression of NR1I3 mRNA; [Chlorpromazine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Chlorpromazine inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]]
NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP2B10 mRNA]; NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP3A11 mRNA]

PMID:10037683 PMID:12049174 PMID:12948398 PMID:17041008 PMID:22310298 More...

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

Chlorpromazine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear protein 1, transcriptional regulator

increases expression

Chlorpromazine results in increased expression of NUPR1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

origin recognition complex, subunit 1

decreases expression

Chlorpromazine analog results in decreased expression of ORC1 mRNA

NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375

G

orosomucoid 1

affects binding
multiple interactions

Chlorpromazine binds to ORM1 protein alternative form
Chlorpromazine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

protein disulfide isomerase family A, member 2

increases expression

Chlorpromazine analog results in increased expression of PDIA2 mRNA

NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931

G

protein disulfide isomerase family A, member 5

decreases expression

Chlorpromazine results in decreased expression of PDIA5 mRNA

NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084

G

pyruvate dehydrogenase kinase 1

increases expression

Chlorpromazine results in increased expression of PDK1 mRNA

NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038

G

pyruvate dehydrogenase kinase 4

increases expression

Chlorpromazine results in increased expression of PDK4 mRNA

NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850

G

phytanoyl-CoA 2-hydroxylase

increases expression

Chlorpromazine results in increased expression of PHYH mRNA

NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409

G

protein inhibitor of activated STAT, 1

increases expression

Chlorpromazine results in increased expression of PIAS1 mRNA

NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905

G

Pim-1 proto-oncogene, serine/threonine kinase

increases expression

Chlorpromazine analog results in increased expression of PIM1 mRNA

NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174

G

pirin

decreases expression

Chlorpromazine results in decreased expression of PIR mRNA

NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218

G

perilipin 2

increases expression

Chlorpromazine results in increased expression of PLIN2 mRNA

NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319

G

prostate transmembrane protein, androgen induced 1

decreases expression

Chlorpromazine results in decreased expression of PMEPA1 mRNA

NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454

G

DNA polymerase alpha 1, catalytic subunit

decreases expression

Chlorpromazine analog results in decreased expression of POLA1 mRNA

NCBI chr X:58,034,617...58,348,612
Ensembl chr X:58,034,619...58,348,536

G

DNA polymerase delta 4, accessory subunit

increases expression

Chlorpromazine analog results in increased expression of POLD4 mRNA

NCBI chr 1:201,526,591...201,528,406
Ensembl chr 1:201,526,665...201,528,401

G

POU class 5 homeobox 1

decreases expression

Chlorpromazine results in decreased expression of POU5F1 mRNA

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator-activated receptor gamma

affects activity

Chlorpromazine affects the activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 1, regulatory subunit 15A

increases expression

Chlorpromazine results in increased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

protein kinase AMP-activated catalytic subunit alpha 1

decreases phosphorylation

Chlorpromazine results in decreased phosphorylation of PRKAA1 protein

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

prolactin

increases expression

Chlorpromazine results in increased expression of PRL protein

PMID:718334 PMID:996201

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

retinoic acid receptor, alpha

decreases expression

Chlorpromazine results in decreased expression of RARA mRNA

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

Rho family GTPase 1

decreases expression

Chlorpromazine results in decreased expression of RND1 mRNA

NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399

G

Rho family GTPase 3

decreases expression

Chlorpromazine results in decreased expression of RND3 mRNA

NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327

G

ring finger protein 121

decreases expression

Chlorpromazine results in decreased expression of RNF121 mRNA

NCBI chr 1:156,377,368...156,439,936
Ensembl chr 1:156,377,364...156,446,826

G

RUNX family transcription factor 1

increases expression

Chlorpromazine results in increased expression of RUNX1 mRNA

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

retinoid X receptor gamma

affects response to substance

RXRG protein affects the susceptibility to Chlorpromazine

NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167

G

spermidine/spermine N1-acetyl transferase 1

increases expression

Chlorpromazine results in increased expression of SAT1 mRNA

NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813

G

sterol-C5-desaturase

increases expression

Chlorpromazine results in increased expression of SC5D mRNA

NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273

G

serine (or cysteine) peptidase inhibitor, clade A, member 3N

increases expression

Chlorpromazine results in increased expression of SERPINA3 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

serpin family H member 1

increases expression

Chlorpromazine results in increased expression of SERPINH1 mRNA

NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801

G

sestrin 1

decreases expression

Chlorpromazine results in decreased expression of SESN1 mRNA

NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697

G

salt-inducible kinase 1

decreases expression

Chlorpromazine results in decreased expression of SIK1 mRNA

NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991

G

solute carrier family 10 member 1

decreases expression
increases expression

Chlorpromazine results in decreased expression of SLC10A1 mRNA
Chlorpromazine results in increased expression of SLC10A1 mRNA

PMID:27765674 PMID:28391356 PMID:35708773

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 12, member 8

increases expression

Chlorpromazine results in increased expression of SLC12A8 mRNA

NCBI chr11:67,116,876...67,266,548
Ensembl chr11:67,116,877...67,266,834

G

solute carrier family 19 member 1

multiple interactions
decreases activity

Chlorpromazine inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]
Chlorpromazine results in decreased activity of SLC19A1 protein

NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972

G

solute carrier family 1 member 5

increases expression

Chlorpromazine results in increased expression of SLC1A5 mRNA

NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 22 member 2

multiple interactions

Chlorpromazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 7

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of SLC22A7 mRNA

NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921

G

solute carrier family 2 member 3

decreases expression

Chlorpromazine results in decreased expression of SLC2A3 mRNA

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

G

solute carrier family 31 member 1

multiple interactions

Chlorpromazine inhibits the reaction [Copper affects the localization of SLC31A1 protein]

NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228

G

solute carrier family 3 member 2

increases expression

Chlorpromazine results in increased expression of SLC3A2 mRNA

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

SLC51 subunit beta

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of SLC51B mRNA

NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145

G

solute carrier family 6 member 6

increases expression

Chlorpromazine results in increased expression of SLC6A6 mRNA

NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875

G

solute carrier organic anion transporter family, member 2b1

decreases expression

Chlorpromazine results in decreased expression of SLCO2B1 mRNA

NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353

G

superoxide dismutase 1

multiple interactions

Chlorpromazine inhibits the reaction [Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

SRY-box transcription factor 2

decreases expression

Chlorpromazine results in decreased expression of SOX2 mRNA

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

secreted phosphoprotein 1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

splA/ryanodine receptor domain and SOCS box containing 1

increases expression

Chlorpromazine results in increased expression of SPSB1 mRNA

NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

Chlorpromazine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased phosphorylation of SRC protein]

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

sterol regulatory element binding transcription factor 2

multiple interactions

Chlorpromazine results in increased cleavage of and results in increased activity of SREBF2 protein

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

spermatid perinuclear RNA binding protein

increases expression

Chlorpromazine results in increased expression of STRBP mRNA

NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949

G

steroid sulfatase

multiple interactions

Chlorpromazine inhibits the reaction [Tretinoin results in increased activity of STS protein]

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

transgelin

decreases expression

Chlorpromazine results in decreased expression of TAGLN mRNA

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

transferrin

affects localization

Chlorpromazine affects the localization of TF protein

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transcription factor Dp-1

decreases expression

Chlorpromazine analog results in decreased expression of TFDP1 mRNA

NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817

G

TCDD-inducible poly(ADP-ribose) polymerase

increases expression

Chlorpromazine results in increased expression of TIPARP mRNA

NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327

G

TIR domain containing adaptor protein

multiple interactions

TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipoteichoic acid]

NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432

G

tumor necrosis factor

decreases expression
increases response to substance
multiple interactions

Chlorpromazine analog results in decreased expression of TNF protein; Chlorpromazine results in decreased expression of TNF mRNA
TNF protein results in increased susceptibility to Chlorpromazine
[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein; [Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein; Chlorpromazine inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride]; Chlorpromazine inhibits the reaction [hydroquinone results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased susceptibility to Chlorpromazine]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein]
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine; Chlorpromazine results in decreased expression of and results in decreased activity of TNF protein

PMID:8550079 PMID:15052360 PMID:19362101 PMID:20371967 PMID:22414385 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 8

increases expression

Chlorpromazine results in increased expression of TNFAIP8 mRNA

NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517

G

TNF receptor superfamily member 14

increases expression

Chlorpromazine analog results in increased expression of TNFRSF14 mRNA

NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703

G

TNF superfamily member 11

decreases activity
multiple interactions

Chlorpromazine results in decreased activity of TNFSF11; Chlorpromazine results in decreased activity of TNFSF11 protein
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

tumor protein p53

affects activity

Chlorpromazine affects the activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TRAF type zinc finger domain containing 1

decreases expression

Chlorpromazine results in decreased expression of TRAFD1 mRNA

NCBI chr12:35,165,606...35,179,525
Ensembl chr12:35,165,606...35,179,525

G

tubulin, alpha 1A

decreases expression

Chlorpromazine results in decreased expression of TUBA1A mRNA

NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186

G

thioredoxin 1

decreases expression

Chlorpromazine results in decreased expression of TXN1 mRNA

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin reductase 1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

tyrosinase

increases expression

Chlorpromazine results in increased expression of TYR protein

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

G

uracil-DNA glycosylase

decreases expression

Chlorpromazine analog results in decreased expression of UNG mRNA

NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206

G

unk like zinc finger

decreases expression

Chlorpromazine results in decreased expression of UNKL mRNA

NCBI chr10:14,206,125...14,252,226
Ensembl chr10:14,206,189...14,252,225

G

vascular endothelial growth factor A

increases expression

Chlorpromazine analog results in increased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor B

increases expression

Chlorpromazine results in increased expression of VEGFB mRNA

NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944

G

tryptophanyl-tRNA synthetase 1

increases expression

Chlorpromazine results in increased expression of WARS1 mRNA

NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269

G

WD repeat domain, phosphoinositide interacting 1

increases expression

Chlorpromazine results in increased expression of WIPI1 mRNA

PMID:15342952 PMID:17175557

NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846

G

X-box binding protein 1

affects activity
decreases expression

Chlorpromazine affects the activity of XBP1 protein
Chlorpromazine results in decreased expression of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

G

XPC complex subunit, DNA damage recognition and repair factor

decreases expression

Chlorpromazine results in decreased expression of XPC mRNA

NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010

G

X-ray repair cross complementing 4

decreases expression

Chlorpromazine results in decreased expression of XRCC4 mRNA

NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808

G

Yes1 associated transcriptional regulator

multiple interactions

Chlorpromazine results in decreased expression of and results in increased phosphorylation of and affects the localization of YAP1 protein

NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010

cyamemazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

cyamemazine metabolite results in decreased activity of KCNH2 protein; cyamemazine results in decreased activity of KCNH2 protein

PMID:16494862 PMID:18957172

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

fenoverine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

fenoverine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

fluphenazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminolevulinate dehydratase

multiple interactions
decreases activity

[Fluphenazine co-treated with diphenyldiselenide] results in decreased activity of ALAD protein
Fluphenazine results in decreased activity of ALAD protein

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

androgen receptor

multiple interactions

Fluphenazine binds to and results in decreased activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

catalase

multiple interactions
increases activity

diphenyldiselenide inhibits the reaction [Fluphenazine results in increased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

Fluphenazine results in decreased activity of CYP2C19 protein

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

Fluphenazine results in decreased activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

Fluphenazine results in decreased activity of CYP3A4 protein

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

dopamine receptor D2

affects binding

Fluphenazine binds to DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

5-hydroxytryptamine receptor 2A

affects binding

Fluphenazine binds to HTR2A protein

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

5-hydroxytryptamine receptor 2C

affects binding

Fluphenazine binds to HTR2C protein

NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287

G

nerve growth factor

multiple interactions

Fluphenazine inhibits the reaction [NGF protein results in increased uptake of Calcium]

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

prolactin

increases secretion

Fluphenazine results in increased secretion of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

solute carrier family 22 member 2

multiple interactions

Fluphenazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

tachykinin, precursor 1

decreases expression

Fluphenazine results in decreased expression of TAC1 mRNA

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

transcription factor EB

affects localization

Fluphenazine affects the localization of TFEB protein

NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714

G

transmembrane serine protease 2

increases expression

Fluphenazine results in increased expression of TMPRSS2 mRNA

NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715

Mequitazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases hydroxylation
multiple interactions

CYP2D6 protein results in increased hydroxylation of mequitazine
Nicardipine inhibits the reaction [CYP2D6 protein results in increased hydroxylation of mequitazine]

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

mesoridazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Mesoridazine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

methdilazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

methdilazine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

moricizine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression

Moricizine results in increased expression of CYP2B6 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

Moricizine results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

parathiazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

pyrathiazine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

pecazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

mepazine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

solute carrier family 22 member 2

multiple interactions

mepazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

perazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases methylation

CYP3A4 protein results in decreased methylation of Perazine

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

flavin containing dimethylaniline monoxygenase 3

increases oxidation

FMO3 protein results in increased oxidation of Perazine

NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028

periciazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

periciazine binds to and results in decreased activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

potassium voltage-gated channel subfamily H member 2

decreases activity

periciazine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

perphenazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carboxylesterase 1D

multiple interactions

Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Perphenazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

follicle stimulating hormone subunit beta

decreases expression

Perphenazine results in decreased expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

Perphenazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Perphenazine results in decreased activity of KCNH2 protein

PMID:21158687 PMID:28551711

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

luteinizing hormone subunit beta

decreases expression

Perphenazine results in decreased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

prolactin

increases expression

Perphenazine results in increased expression of PRL protein

PMID:6770916 PMID:7262630 PMID:17335319

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

solute carrier family 22 member 2

multiple interactions

Perphenazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

troponin I3, cardiac type

increases expression

Perphenazine results in increased expression of TNNI3 protein

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

prochlorperazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

increases activity

Prochlorperazine results in increased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

estrogen receptor 1

multiple interactions

Prochlorperazine binds to and results in increased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

transcription factor EB

affects localization

Prochlorperazine affects the localization of TFEB protein

NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714

profenamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

decreases activity
multiple interactions

profenamine results in decreased activity of BCHE protein
profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]; profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]; profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]

PMID:18656440 PMID:22407886 PMID:28299395 PMID:32278739 PMID:32795450

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

potassium voltage-gated channel subfamily H member 2

decreases activity

profenamine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

promazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

decreases activity

Promazine results in decreased activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

corticotropin releasing hormone

decreases expression

Promazine results in decreased expression of CRH mRNA

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Promazine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

solute carrier family 22 member 2

multiple interactions

Promazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

promethazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

autophagy and beclin 1 regulator 1

decreases expression

Promethazine results in decreased expression of AMBRA1 protein

NCBI chr 3:77,700,936...77,890,221
Ensembl chr 3:77,700,936...77,890,221

G

autophagy related 5

decreases expression

Promethazine results in decreased expression of ATG5 protein

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

autophagy related 7

decreases expression

Promethazine results in decreased expression of ATG7 protein

NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593

G

ATM serine/threonine kinase

decreases expression

Promethazine results in decreased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATP synthase F1 subunit beta

decreases expression

Promethazine results in decreased expression of ATP5F1B mRNA

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

aurora kinase A

decreases expression

Promethazine results in decreased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

aurora kinase B

decreases expression

Promethazine results in decreased expression of AURKB mRNA

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

BCL2-antagonist/killer 1

increases expression

Promethazine results in increased expression of BAK1 protein

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

butyrylcholinesterase

decreases activity

Promethazine results in decreased activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

decreases expression

Promethazine results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

Promethazine results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

beclin 1

multiple interactions

Promethazine affects the expression of and results in increased phosphorylation of BECN1 protein

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

BRCA1, DNA repair associated

decreases expression

Promethazine results in decreased expression of BRCA1 mRNA

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

BRCA2, DNA repair associated

decreases expression

Promethazine results in decreased expression of BRCA2 mRNA

NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567

G

BRCA1/BRCA2-containing complex subunit 3

decreases expression

Promethazine results in decreased expression of BRCC3 mRNA

NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080

G

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

Promethazine results in decreased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

G

caspase 3

decreases cleavage

Promethazine results in decreased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cyclin-dependent kinase inhibitor 1A

increases expression
increases phosphorylation
decreases expression

Promethazine results in increased expression of CDKN1A protein
Promethazine results in increased phosphorylation of CDKN1A protein
Promethazine results in decreased expression of CDKN1A mRNA

PMID:26011634 PMID:26558467

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

decreases expression

Promethazine results in decreased expression of CDKN2A mRNA

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

checkpoint kinase 1

increases expression
decreases expression

Promethazine results in increased expression of CHEK1 mRNA
Promethazine results in decreased expression of CHEK1 mRNA

PMID:26011634 PMID:26558467

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

decreases expression

Promethazine results in decreased expression of CHEK2 mRNA

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases metabolic processing

CYP2D6 gene polymorphism results in decreased metabolism of Promethazine

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

establishment of sister chromatid cohesion N-acetyltransferase 1

decreases expression

Promethazine results in decreased expression of ESCO1 mRNA

NCBI chr18:1,630,560...1,686,803
Ensembl chr18:1,631,954...1,686,942

G

glucose-6-phosphate dehydrogenase

increases expression

Promethazine results in increased expression of G6PD mRNA

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth arrest and DNA-damage-inducible, alpha

affects expression

Promethazine affects the expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression

Promethazine results in decreased expression of GAPDH mRNA

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

H2A.X variant histone

decreases expression

Promethazine results in decreased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

hypoxia inducible factor 1 subunit alpha

decreases expression

Promethazine results in decreased expression of HIF1A mRNA

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

hexokinase 2

decreases expression

Promethazine results in decreased expression of HK2 mRNA

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

histamine receptor H 1

multiple interactions

Promethazine binds to and results in decreased activity of HRH1 protein; Promethazine binds to and results in increased activity of HRH1 protein; Promethazine inhibits the reaction [Pyrilamine binds to HRH1 protein]

PMID:1377455 PMID:1912125

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

histamine receptor H 2

multiple interactions

Promethazine binds to and results in decreased activity of HRH2 protein

NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631

G

heat shock transcription factor 1

decreases activity

Promethazine results in decreased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

interleukin 1 alpha

increases expression

Promethazine results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression

Promethazine results in increased expression of IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression

Promethazine results in increased expression of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

mitotic arrest deficient 1 like 1

decreases expression

Promethazine results in decreased expression of MAD1L1 mRNA

NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703

G

mitotic arrest deficient 2 like 1

increases expression
decreases expression

Promethazine results in increased expression of MAD2L1 mRNA
Promethazine results in decreased expression of MAD2L1 mRNA

PMID:26011634 PMID:26558467

NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

Promethazine results in decreased expression of MCL1 protein

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

MDM2 proto-oncogene

increases phosphorylation

Promethazine results in increased phosphorylation of MDM2 protein

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

marker of proliferation Ki-67

increases expression
affects expression

Promethazine results in increased expression of MKI67 protein
Promethazine affects the expression of MKI67 protein

PMID:26011634 PMID:26558467

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

mechanistic target of rapamycin kinase

multiple interactions

Promethazine results in decreased expression of and results in decreased phosphorylation of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

Promethazine results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

natural killer cell cytotoxicity receptor 3 ligand 1

increases expression

Promethazine results in increased expression of NCR3LG1 mRNA; Promethazine results in increased expression of NCR3LG1 protein

NCBI chr 1:96,565,664...96,581,825
Ensembl chr 1:96,574,455...96,580,466

G

nerve growth factor

multiple interactions

Promethazine inhibits the reaction [Capsaicin results in increased expression of NGF protein]

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

phosphoglycerate mutase 1

increases expression

Promethazine results in increased expression of PGAM1 mRNA

NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452

G

phosphotyrosine interaction domain containing 1

increases expression

Promethazine results in increased expression of PID1 mRNA

NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044

G

pyruvate kinase M1/2

decreases expression

Promethazine results in decreased expression of PKM mRNA

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

polo-like kinase 1

decreases expression

Promethazine results in decreased expression of PLK1 mRNA

NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

Promethazine results in increased expression of PMAIP1 protein

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

RAD17 checkpoint clamp loader component

decreases expression

Promethazine results in decreased expression of RAD17 mRNA

NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072

G

RB transcriptional corepressor 1

decreases expression

Promethazine results in decreased expression of RB1 mRNA

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RB transcriptional corepressor like 2

decreases expression

Promethazine results in decreased expression of RBL2 mRNA

PMID:26011634 PMID:26558467

NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572

G

solute carrier family 22 member 5

multiple interactions

Promethazine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Promethazine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]

NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309

G

solute carrier family 2 member 1

decreases expression

Promethazine results in decreased expression of SLC2A1 mRNA

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 2 member 2

decreases expression

Promethazine results in decreased expression of SLC2A2 mRNA

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

sequestosome 1

increases expression

Promethazine results in increased expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

tumor necrosis factor

increases expression

Promethazine results in increased expression of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 11

decreases activity

Promethazine results in decreased activity of TNFSF11

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

DNA topoisomerase II alpha

affects expression

Promethazine affects the expression of TOP2A protein

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

decreases expression

Promethazine results in decreased expression of TP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

ubiquitin D

decreases expression

Promethazine results in decreased expression of UBD protein

NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639

G

unc-51 like autophagy activating kinase 1

increases expression

Promethazine results in increased expression of ULK1 protein

NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966

thiethylperazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

multiple interactions

[Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

amyloid beta precursor protein

multiple interactions

[Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

thioridazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

Thioridazine results in decreased expression of AP1S1 mRNA

PMID:15342952 PMID:17175557

NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713

G

N-acylsphingosine amidohydrolase 1

increases expression

Thioridazine results in increased expression of ASAH1 mRNA

NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

Thioridazine results in increased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

caspase 3

increases activity

Thioridazine results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cyclin D1

decreases expression

Thioridazine results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cell division cycle 25A

increases phosphorylation

Thioridazine results in increased phosphorylation of CDC25A protein

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cyclin-dependent kinase 4

decreases expression

Thioridazine results in decreased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

increases expression

Thioridazine results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

increases expression

Thioridazine results in increased expression of CDKN2A protein

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

carboxylesterase 1D

multiple interactions

Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

corticotropin releasing hormone

decreases expression

Thioridazine results in decreased expression of CRH mRNA

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP1A2 protein results in increased metabolism of and results in increased activity of Thioridazine

PMID:19482014 PMID:23397584

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
decreases activity

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine
Thioridazine results in decreased activity of CYP2C19 protein

PMID:15135088 PMID:23397584

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP2D6 protein results in increased metabolism of and results in increased activity of Thioridazine

PMID:19482014 PMID:23397584

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

Thioridazine results in decreased activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases activity

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine
Thioridazine results in decreased activity of CYP3A4 protein

PMID:15135088 PMID:23397584

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

DEPP autophagy regulator 1

increases expression

Thioridazine results in increased expression of DEPP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

eukaryotic translation initiation factor 4E binding protein 1

decreases phosphorylation

Thioridazine results in decreased phosphorylation of EIF4EBP1 protein

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

fatty acid binding protein 1

increases expression

Thioridazine results in increased expression of FABP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

fibronectin type III domain containing 4

increases expression

Thioridazine results in increased expression of FNDC4 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675

G

glycerophosphodiester phosphodiesterase domain containing 3

increases expression

Thioridazine results in increased expression of GDPD3 mRNA

NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063

G

hepsin

increases expression

Thioridazine results in increased expression of HPN mRNA

NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811

G

inhibin subunit beta E

increases expression

Thioridazine results in increased expression of INHBE mRNA

PMID:15342952 PMID:17175557

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

Thioridazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Thioridazine results in decreased activity of KCNH2 protein

PMID:15671647 PMID:16278312 PMID:21158687 PMID:24052561

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

lanosterol synthase

increases expression

Thioridazine results in increased expression of LSS mRNA

PMID:15342952 PMID:17175557

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

nuclear receptor subfamily 0, group B, member 2

increases expression

Thioridazine results in increased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear protein 1, transcriptional regulator

increases expression

Thioridazine results in increased expression of NUPR1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

phytanoyl-CoA 2-hydroxylase

increases expression

Thioridazine results in increased expression of PHYH mRNA

NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409

G

prolactin

increases expression

Thioridazine results in increased expression of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

serine (or cysteine) peptidase inhibitor, clade A, member 3N

increases expression

Thioridazine results in increased expression of SERPINA3 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

solute carrier family 22 member 2

multiple interactions

Thioridazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 2 member 3

decreases expression

Thioridazine results in decreased expression of SLC2A3 mRNA

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

G

transgelin

decreases expression

Thioridazine results in decreased expression of TAGLN mRNA

PMID:15342952 PMID:17175557

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

tumor protein p53

affects activity

Thioridazine affects the activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

WD repeat domain, phosphoinositide interacting 1

increases expression

Thioridazine results in increased expression of WIPI1 mRNA

PMID:15342952 PMID:17175557

NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846

trifluoperazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases activity

Trifluoperazine results in increased activity of ABCB1 protein

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

acetylcholinesterase

multiple interactions
increases activity
decreases expression

energostim inhibits the reaction [Trifluoperazine results in decreased expression of ACHE protein]
Trifluoperazine results in increased activity of ACHE protein

PMID:15232633 PMID:29614332

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

AKT serine/threonine kinase 1

multiple interactions

Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of AKT1 protein]

PMID:19233221 PMID:21544200

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

ATPase H+ transporting V1 subunit H

multiple interactions

[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA

NCBI chr 5:14,379,029...14,484,703
Ensembl chr 5:14,378,257...14,537,962

G

BCL2 associated X, apoptosis regulator

increases expression

Trifluoperazine results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

Trifluoperazine results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

calcium/calmodulin-dependent protein kinase II alpha

multiple interactions

Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein]

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

G

caspase 3

multiple interactions

Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

CD44 molecule

multiple interactions

Trifluoperazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD44 protein]

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein]

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

flavin containing dimethylaniline monoxygenase 2

increases oxidation

FMO2 protein results in increased oxidation of Trifluoperazine

NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308

G

gamma-aminobutyric acid type B receptor subunit 1

multiple interactions

Trifluoperazine inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]

NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994

G

gamma-aminobutyric acid type B receptor subunit 2

multiple interactions

Trifluoperazine inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]

NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104

G

hypoxia inducible factor 1 subunit alpha

decreases expression

Trifluoperazine results in decreased expression of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

interleukin 12B

multiple interactions

Trifluoperazine inhibits the reaction [Hydrogen Peroxide results in decreased expression of IL12B protein]

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

potassium voltage-gated channel subfamily H member 2

multiple interactions

Trifluoperazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium calcium-activated channel subfamily N member 2

decreases activity

Trifluoperazine results in decreased activity of KCNN2 protein

NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347

G

lysosomal-associated membrane protein 1

multiple interactions

[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA

NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883

G

mitogen activated protein kinase 1

multiple interactions

Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Trifluoperazine inhibits the reaction [Dinoprost results in increased activity of MAPK1 protein]

PMID:11914123 PMID:21544200

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions

Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK14 protein]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions

Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Trifluoperazine inhibits the reaction [Dinoprost results in increased activity of MAPK3 protein]

PMID:11914123 PMID:21544200

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

metallothionein 1

increases expression

Trifluoperazine results in increased expression of MT1A mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

G

mechanistic target of rapamycin kinase

multiple interactions
decreases phosphorylation

Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]
Trifluoperazine analog results in decreased phosphorylation of MTOR protein
STON2 protein inhibits the reaction [Trifluoperazine analog results in decreased phosphorylation of MTOR protein]

PMID:21544200 PMID:36702439

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

myosin light chain 9

multiple interactions

Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MYL9 protein]; Trifluoperazine inhibits the reaction [Ionomycin results in increased phosphorylation of MYL9 protein]

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

G

neurofilament light chain

multiple interactions

Trifluoperazine inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA]

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

nuclear receptor subfamily 3, group C, member 1

decreases activity

Trifluoperazine results in decreased activity of NR3C1 protein

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

poly (ADP-ribose) polymerase 1

multiple interactions

Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

PTEN induced kinase 1

multiple interactions

[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]]

NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635

G

parkin RBR E3 ubiquitin protein ligase

affects localization
multiple interactions

Trifluoperazine affects the localization of PRKN protein
PRKN protein affects the reaction [Trifluoperazine affects the localization of PRKN protein]

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

prolactin

increases expression

Trifluoperazine results in increased expression of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

REL proto-oncogene, NF-kB subunit

multiple interactions

Trifluoperazine inhibits the reaction [Hydrogen Peroxide results in decreased localization of REL protein]

NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892

G

ribosomal protein S6 kinase B1

multiple interactions

Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

solute carrier family 5 member 6

multiple interactions

Trifluoperazine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]

NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712

G

stonin 2

decreases expression
multiple interactions

Trifluoperazine analog results in decreased expression of STON2 protein
STON2 protein inhibits the reaction [Trifluoperazine analog results in decreased phosphorylation of MTOR protein]

NCBI chr 6:110,567,485...110,676,376
Ensembl chr 6:110,567,485...110,676,376

G

transcription factor EB

multiple interactions

[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]]

NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714

G

TNF superfamily member 11

decreases activity

Trifluoperazine results in decreased activity of TNFSF11

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

UDP glucuronosyltransferase family 1 member A5

increases glucuronidation
multiple interactions
increases activity

UGT1A4 protein results in increased glucuronidation of Trifluoperazine
Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine]; hecogenin inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine]; licochalcone A inhibits the reaction [Trifluoperazine results in increased activity of UGT1A4 protein]; Trifluoperazine inhibits the reaction [UGT1A4 protein results in increased glucuronidation of afloqualone]

PMID:15135306 PMID:15475412 PMID:25393417 PMID:25448279 PMID:26875642 More...

NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465

triflupromazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Triflupromazine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19808
chemical entity	19806
molecular entity	19806
polyatomic entity	19764
molecule	19670
cyclic compound	19486
polycyclic compound	18808
heteropolycyclic compound	18278
heterotricyclic compound	15623
organic heterotricyclic compound	15623
phenothiazines	365
(4-methylphenyl)-(10-phenothiazinyl)methanone	0
1-(1-benzotriazolyl)-3-(10-phenothiazinyl)-2-propanol	0
1-(10-methyl-2-phenothiazinyl)ethanone	0
1-(10H-phenothiazin-2-yl)ethanone	0
1-(2-chloro-10-phenothiazinyl)-2-[(1-methyl-5-tetrazolyl)thio]ethanone	0
1-(dimethylamino)-3-(10-phenothiazinyl)-2-propanol	0
1-[10-[3-[4-(2-hydroxyethyl)-1-piperidinyl]propyl]-2-phenothiazinyl]ethanone	1
1-methyl-1-[1-oxo-1-(10H-phenothiazin-10-yl)propan-2-yl]pyrrolidinium +	0
10-(3-aminopropyl)-8-chlorophenothiazine-2,3-diol	0
10-(beta-Dimethylaminopropionyl)phenothiazine	1
10-[(2R)-3-(dimethylamino)-2-methylpropyl]phenothiazine-2,3-diol	0
10-[(2R)-3-(dimethylamino)-2-methylpropyl]phenothiazine-2,7-diol	0
10-[3-(dimethylamino)-2-methylpropyl]-2-methoxy-5lambda4-phenothiazin-5-one	0
10-[3-[4-(2-adamantyl)-1-piperazinyl]propyl]-2-chlorophenothiazine	0
10-[3-[4-(2-chloroethyl)-1-piperazinyl]propyl]-2-(trifluoromethyl)phenothiazine	0
10-methyl-2-(trifluoromethyl)phenothiazine	0
10-methyl-3-phenothiazinamine	0
10-methylphenothiazine	0
10H-phenothiazine 5-oxide	0
2-(2-chloro-10-phenothiazinyl)-N,N-dimethylethanamine	0
2-(trifluoromethyl)-10H-phenothiazine	0
2-[3-(4-methylphenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-1-ium-1-yl]-1-(10-phenothiazinyl)ethanone	0
2-[[4-ethyl-5-(2-furanyl)-1,2,4-triazol-3-yl]thio]-1-(10-phenothiazinyl)ethanone	0
2-chloro-10-ethylphenothiazine	0
2-chloro-10-phenothiazinecarboxylic acid ethyl ester	0
2-chloro-7-methoxy-10H-phenothiazine	0
2-chloro-N-[1-[oxo(10-phenothiazinyl)methyl]-4-piperidinyl]benzamide	0
2-methoxy-10H-phenothiazine	0
3,7-bis(dimethylamino)phenothiazine	0
3-(2-chloro-10-oxido-10-phenothiazin-10-iumyl)-N,N-dimethyl-1-propanamine	0
3-(2-chloro-10-phenothiazinyl)-1-propanamine	0
3-(2-chloro-10-phenothiazinyl)-N-methyl-1-propanamine	0
3-(2-chloro-5,5-dioxo-10-phenothiazinyl)-N,N-dimethyl-1-propanamine	0
3-(2-chloro-5-oxo-10-phenothiazinyl)-1-propanamine	0
3-(2-chloro-5-oxo-10-phenothiazinyl)-N,N-dimethyl-1-propanamine	0
3-(2-chloro-5-oxo-10-phenothiazinyl)-N-methyl-1-propanamine	0
3-(2-chloro-7-hydroxy-10-phenothiazinyl)propyl-trimethylammonium	0
3-(2-chloro-7-methoxy-10-phenothiazinyl)-N,N-dimethyl-1-propanamine	0
3-(8-chloro-2,3-dimethoxy-10-phenothiazinyl)-N,N-dimethyl-1-propanamine	0
3-Hydroxylevomepromazine	0
3-[4-(2-hydroxyethyl)-1-piperazinyl]-1-[2-(trifluoromethyl)-10-phenothiazinyl]-1-propanone	0
7-hydroxyfluphenazine	0
7-hydroxylevomepromazine	0
7-hydroxyprochlorperazine	0
8-chloro-10-[3-(dimethylamino)propyl]-3-phenothiazinol	0
8-chloro-10-[3-(dimethylamino)propyl]phenothiazine-2,3-diol	0
8-chloro-10-[3-(methylamino)propyl]-3-phenothiazinol	0
8-chloro-10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]phenothiazine-2,3-diol	0
Clospirazine hydrochloride	0
Desmethyltrimeprazine	0
Dinorpromazine	0
Fluphenazine Sulfoxide	0
Fluphenazine enanthate	0
Fluphenazine hydrochloride	0
Levomepromazine hydrochloride	0
Mequitazine	1
Moricizine sulfone	0
Moricizine sulfoxide	0
N'-(2-furylmethylene)-2-(10H-phenothiazin-10-yl)acetohydrazide	0
N'-[3-(2-chloro-10-phenothiazinyl)propyl]butane-1,4-diamine	0
N,N,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine	0
N,N-didesmethyllevomepromazine	0
N-Desmethyllevomepromazine	0
N-Desmethylperazine	0
N-Desmethylpromazine	0
N-[(4-nitrophenyl)methylideneamino]-2-(10-phenothiazinyl)acetamide	0
N-methyl-3-(5-oxo-10-phenothiazinyl)-1-propanamine	0
N-methyl-3-[2-(trifluoromethyl)-10-phenothiazinyl]-1-propanamine	0
O-desmethyllevomepromazine	0
Perazine maleate	0
Promethazine sulfoxide	0
Promethazine teoclate	0
Thioproperazine mesilate	0
Trimeprazine	0
acepromazine	1
aceprometazine +	0
acetophenazine +	1
aminopromazine	0
butaperazine	0
carfenazine +	0
chlorproethazine	0
chlorpromazine +	276
chlorpromazine N-oxide	0
chlorpromazine hydrochloride	0
cyamemazine	1
diethazine	0
dimethothiazine mesylate	0
dimethoxanate	0
dimetotiazine	0
dixyrazine	0
ethacizine	0
etymemazine	0
fenethazine	0
fenoverine	1
fluacizine	0
fluphenazine +	14
fluphenazine decanoate	0
homofenazine	0
hydroxyethylpromethazine	0
imiclopazine	0
isopromethazine	0
leucomethylene blue	0
mesoridazine +	1
methdilazine +	1
methopromazine	0
methotrimeprazine	0
metiazinic acid	0
metofenazate	0
metopimazine	0
moricizine +	2
oxaflumazine	0
oxomemazine	0
pacatal	0
parathiazine	1
pecazine	2
perazine +	4
periciazine	2
perimetazine	0
perphenazine +	8
perphenazine decanoate	0
phenothiazine +	31
pipamazine	0
pipotiazine palmitate	0
prochlorperazine +	3
profenamine +	2
promazine +	4
promazine sulfoxide	0
promethazine	62
propiomazine +	0
spiclomazine	0
sulforidazine	0
thiazinam	0
thiethylperazine +	2
thiopropazate	0
thioproperazine	0
thioridazine +	35
trifluoperazine +	39
triflupromazine +	1
Path 2
Term	Annotations
CHEBI ontology	19808
subatomic particle	19806
composite particle	19806
hadron	19806
baryon	19806
nucleon	19806
atomic nucleus	19806
atom	19806
main group element atom	19756
p-block element atom	19756
carbon group element atom	19705
carbon atom	19702
organic molecular entity	19702
organic molecule	19655
organic cyclic compound	19468
organic heterocyclic compound	18848
organic heteropolycyclic compound	18278
organic heterotricyclic compound	15623
phenothiazines	365
(4-methylphenyl)-(10-phenothiazinyl)methanone	0
1-(1-benzotriazolyl)-3-(10-phenothiazinyl)-2-propanol	0
1-(10-methyl-2-phenothiazinyl)ethanone	0
1-(10H-phenothiazin-2-yl)ethanone	0
1-(2-chloro-10-phenothiazinyl)-2-[(1-methyl-5-tetrazolyl)thio]ethanone	0
1-(dimethylamino)-3-(10-phenothiazinyl)-2-propanol	0
1-[10-[3-[4-(2-hydroxyethyl)-1-piperidinyl]propyl]-2-phenothiazinyl]ethanone	1
1-methyl-1-[1-oxo-1-(10H-phenothiazin-10-yl)propan-2-yl]pyrrolidinium +	0
10-(3-aminopropyl)-8-chlorophenothiazine-2,3-diol	0
10-(beta-Dimethylaminopropionyl)phenothiazine	1
10-[(2R)-3-(dimethylamino)-2-methylpropyl]phenothiazine-2,3-diol	0
10-[(2R)-3-(dimethylamino)-2-methylpropyl]phenothiazine-2,7-diol	0
10-[3-(dimethylamino)-2-methylpropyl]-2-methoxy-5lambda4-phenothiazin-5-one	0
10-[3-[4-(2-adamantyl)-1-piperazinyl]propyl]-2-chlorophenothiazine	0
10-[3-[4-(2-chloroethyl)-1-piperazinyl]propyl]-2-(trifluoromethyl)phenothiazine	0
10-methyl-2-(trifluoromethyl)phenothiazine	0
10-methyl-3-phenothiazinamine	0
10-methylphenothiazine	0
10H-phenothiazine 5-oxide	0
2-(2-chloro-10-phenothiazinyl)-N,N-dimethylethanamine	0
2-(trifluoromethyl)-10H-phenothiazine	0
2-[3-(4-methylphenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-1-ium-1-yl]-1-(10-phenothiazinyl)ethanone	0
2-[[4-ethyl-5-(2-furanyl)-1,2,4-triazol-3-yl]thio]-1-(10-phenothiazinyl)ethanone	0
2-chloro-10-ethylphenothiazine	0
2-chloro-10-phenothiazinecarboxylic acid ethyl ester	0
2-chloro-7-methoxy-10H-phenothiazine	0
2-chloro-N-[1-[oxo(10-phenothiazinyl)methyl]-4-piperidinyl]benzamide	0
2-methoxy-10H-phenothiazine	0
3,7-bis(dimethylamino)phenothiazine	0
3-(2-chloro-10-oxido-10-phenothiazin-10-iumyl)-N,N-dimethyl-1-propanamine	0
3-(2-chloro-10-phenothiazinyl)-1-propanamine	0
3-(2-chloro-10-phenothiazinyl)-N-methyl-1-propanamine	0
3-(2-chloro-5,5-dioxo-10-phenothiazinyl)-N,N-dimethyl-1-propanamine	0
3-(2-chloro-5-oxo-10-phenothiazinyl)-1-propanamine	0
3-(2-chloro-5-oxo-10-phenothiazinyl)-N,N-dimethyl-1-propanamine	0
3-(2-chloro-5-oxo-10-phenothiazinyl)-N-methyl-1-propanamine	0
3-(2-chloro-7-hydroxy-10-phenothiazinyl)propyl-trimethylammonium	0
3-(2-chloro-7-methoxy-10-phenothiazinyl)-N,N-dimethyl-1-propanamine	0
3-(8-chloro-2,3-dimethoxy-10-phenothiazinyl)-N,N-dimethyl-1-propanamine	0
3-Hydroxylevomepromazine	0
3-[4-(2-hydroxyethyl)-1-piperazinyl]-1-[2-(trifluoromethyl)-10-phenothiazinyl]-1-propanone	0
7-hydroxyfluphenazine	0
7-hydroxylevomepromazine	0
7-hydroxyprochlorperazine	0
8-chloro-10-[3-(dimethylamino)propyl]-3-phenothiazinol	0
8-chloro-10-[3-(dimethylamino)propyl]phenothiazine-2,3-diol	0
8-chloro-10-[3-(methylamino)propyl]-3-phenothiazinol	0
8-chloro-10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]phenothiazine-2,3-diol	0
Clospirazine hydrochloride	0
Desmethyltrimeprazine	0
Dinorpromazine	0
Fluphenazine Sulfoxide	0
Fluphenazine enanthate	0
Fluphenazine hydrochloride	0
Levomepromazine hydrochloride	0
Mequitazine	1
Moricizine sulfone	0
Moricizine sulfoxide	0
N'-(2-furylmethylene)-2-(10H-phenothiazin-10-yl)acetohydrazide	0
N'-[3-(2-chloro-10-phenothiazinyl)propyl]butane-1,4-diamine	0
N,N,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine	0
N,N-didesmethyllevomepromazine	0
N-Desmethyllevomepromazine	0
N-Desmethylperazine	0
N-Desmethylpromazine	0
N-[(4-nitrophenyl)methylideneamino]-2-(10-phenothiazinyl)acetamide	0
N-methyl-3-(5-oxo-10-phenothiazinyl)-1-propanamine	0
N-methyl-3-[2-(trifluoromethyl)-10-phenothiazinyl]-1-propanamine	0
O-desmethyllevomepromazine	0
Perazine maleate	0
Promethazine sulfoxide	0
Promethazine teoclate	0
Thioproperazine mesilate	0
Trimeprazine	0
acepromazine	1
aceprometazine +	0
acetophenazine +	1
aminopromazine	0
butaperazine	0
carfenazine +	0
chlorproethazine	0
chlorpromazine +	276
chlorpromazine N-oxide	0
chlorpromazine hydrochloride	0
cyamemazine	1
diethazine	0
dimethothiazine mesylate	0
dimethoxanate	0
dimetotiazine	0
dixyrazine	0
ethacizine	0
etymemazine	0
fenethazine	0
fenoverine	1
fluacizine	0
fluphenazine +	14
fluphenazine decanoate	0
homofenazine	0
hydroxyethylpromethazine	0
imiclopazine	0
isopromethazine	0
leucomethylene blue	0
mesoridazine +	1
methdilazine +	1
methopromazine	0
methotrimeprazine	0
metiazinic acid	0
metofenazate	0
metopimazine	0
moricizine +	2
oxaflumazine	0
oxomemazine	0
pacatal	0
parathiazine	1
pecazine	2
perazine +	4
periciazine	2
perimetazine	0
perphenazine +	8
perphenazine decanoate	0
phenothiazine +	31
pipamazine	0
pipotiazine palmitate	0
prochlorperazine +	3
profenamine +	2
promazine +	4
promazine sulfoxide	0
promethazine	62
propiomazine +	0
spiclomazine	0
sulforidazine	0
thiazinam	0
thiethylperazine +	2
thiopropazate	0
thioproperazine	0
thioridazine +	35
trifluoperazine +	39
triflupromazine +	1

paths to the root