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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:promethazine
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Accession:CHEBI:8461 term browser browse the term
Definition:A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
Synonyms:exact_synonym: N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
 related_synonym: (2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine;   10-(2-Dimethylaminopropyl)phenothiazine;   10-[2-(dimethylamino)propyl]phenothiazine;   Formula=C17H20N2S;   InChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3;   InChIKey=PWWVAXIEGOYWEE-UHFFFAOYSA-N;   N,N,alpha-trimethyl-10H-phenothiazine-10-ethanamine;   N-(2'-dimethylamino-2'-methyl)ethylphenothiazine;   SMILES=CC(CN1c2ccccc2Sc2ccccc12)N(C)C;   proazamine;   prometazina;   promethazinum
 xref: Beilstein:88554;   CAS:60-87-7;   DrugBank:DB01069;   Drug_Central:2286;   Gmelin:337077;   HMDB:HMDB0015202;   KEGG:C07404;   KEGG:D00494;   LINCS:LSM-4440
 xref_mesh: MESH:D011398
 xref: Patent:US2530451;   Patent:US2607773;   Reaxys:88554;   Wikipedia:Promethazine
 cyclic_relationship: is_conjugate_base_of CHEBI:61214


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promethazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambra1 autophagy and beclin 1 regulator 1 decreases expression ISO Promethazine results in decreased expression of AMBRA1 protein CTD PMID:31682805 NCBI chr 3:80,634,470...80,830,068
Ensembl chr 3:80,634,470...80,830,068
JBrowse link
G Atg5 autophagy related 5 decreases expression ISO Promethazine results in decreased expression of ATG5 protein CTD PMID:31682805 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 decreases expression ISO Promethazine results in decreased expression of ATG7 protein CTD PMID:31682805 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atm ATM serine/threonine kinase decreases expression EXP Promethazine results in decreased expression of ATM mRNA CTD PMID:26011634 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression EXP Promethazine results in decreased expression of ATP5F1B mRNA CTD PMID:28903497 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Aurka aurora kinase A decreases expression EXP Promethazine results in decreased expression of AURKA mRNA CTD PMID:26011634 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G Aurkb aurora kinase B decreases expression EXP Promethazine results in decreased expression of AURKB mRNA CTD PMID:26011634 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Promethazine results in increased expression of BAK1 protein CTD PMID:31682805 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO
EXP
Promethazine results in decreased activity of BCHE protein CTD PMID:236606 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Promethazine results in decreased expression of BCL2 protein CTD PMID:31682805 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Promethazine results in decreased expression of BCL2L1 protein CTD PMID:31682805 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Becn1 beclin 1 multiple interactions ISO Promethazine affects the expression of and results in increased phosphorylation of BECN1 protein CTD PMID:31682805 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression EXP Promethazine results in decreased expression of BRCA1 mRNA CTD PMID:26011634 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Brca2 BRCA2, DNA repair associated decreases expression EXP Promethazine results in decreased expression of BRCA2 mRNA CTD PMID:26011634 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 decreases expression EXP Promethazine results in decreased expression of BRCC3 mRNA CTD PMID:26011634 NCBI chr 9:9,863,380...9,865,920
Ensembl chr 9:9,863,404...9,865,920
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression EXP Promethazine results in decreased expression of BUB1 mRNA CTD PMID:26011634 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Casp3 caspase 3 decreases cleavage EXP Promethazine results in decreased cleavage of CASP3 protein CTD PMID:26011634 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
increases phosphorylation
decreases expression
EXP Promethazine results in increased expression of CDKN1A protein
Promethazine results in increased phosphorylation of CDKN1A protein
Promethazine results in decreased expression of CDKN1A mRNA
CTD PMID:26011634, PMID:26558467 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression EXP Promethazine results in decreased expression of CDKN2A mRNA CTD PMID:26011634 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Chek1 checkpoint kinase 1 increases expression
decreases expression
EXP Promethazine results in increased expression of CHEK1 mRNA
Promethazine results in decreased expression of CHEK1 mRNA
CTD PMID:26011634, PMID:26558467 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 decreases expression EXP Promethazine results in decreased expression of CHEK2 mRNA CTD PMID:26011634 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases metabolic processing ISO CYP2D6 gene polymorphism results in decreased metabolism of Promethazine CTD PMID:19814645 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Esco1 establishment of sister chromatid cohesion N-acetyltransferase 1 decreases expression EXP Promethazine results in decreased expression of ESCO1 mRNA CTD PMID:26011634 NCBI chr18:1,789,796...1,857,271
Ensembl chr18:1,789,900...1,828,606
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression EXP Promethazine results in increased expression of G6PD mRNA CTD PMID:28903497 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression EXP Promethazine affects the expression of GADD45A mRNA CTD PMID:26011634 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression EXP Promethazine results in decreased expression of GAPDH mRNA CTD PMID:28903497 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G H2ax H2A.X variant histone decreases expression EXP Promethazine results in decreased expression of H2AX protein CTD PMID:26011634 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression EXP Promethazine results in decreased expression of HIF1A mRNA CTD PMID:28903497 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hk2 hexokinase 2 decreases expression EXP Promethazine results in decreased expression of HK2 mRNA CTD PMID:28903497 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO Promethazine binds to and results in decreased activity of HRH1 protein; Promethazine binds to and results in increased activity of HRH1 protein; Promethazine inhibits the reaction [Pyrilamine binds to HRH1 protein] CTD PMID:1377455, PMID:1912125 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions ISO Promethazine binds to and results in decreased activity of HRH2 protein CTD PMID:1377455 NCBI chr17:10,912,959...10,931,389
Ensembl chr17:10,921,507...10,952,441
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Promethazine results in increased expression of IL1B protein CTD PMID:15265675 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression EXP Promethazine results in increased expression of IL6 protein CTD PMID:15265675 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 decreases expression EXP Promethazine results in decreased expression of MAD1L1 mRNA CTD PMID:26011634 NCBI chr12:16,410,083...16,721,232
Ensembl chr12:16,410,083...16,719,824
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 increases expression
decreases expression
EXP Promethazine results in increased expression of MAD2L1 mRNA
Promethazine results in decreased expression of MAD2L1 mRNA
CTD PMID:26011634, PMID:26558467 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Promethazine results in decreased expression of MCL1 protein CTD PMID:31682805 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mdm2 MDM2 proto-oncogene increases phosphorylation EXP Promethazine results in increased phosphorylation of MDM2 protein CTD PMID:26558467 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression
affects expression
EXP Promethazine results in increased expression of MKI67 protein
Promethazine affects the expression of MKI67 protein
CTD PMID:26011634, PMID:26558467 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO Promethazine results in decreased expression of and results in decreased phosphorylation of MTOR protein CTD PMID:31682805 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression EXP Promethazine results in decreased expression of MYC mRNA CTD PMID:28903497 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncr3lg1 natural killer cell cytotoxicity receptor 3 ligand 1 increases expression ISO Promethazine results in increased expression of NCR3LG1 mRNA; Promethazine results in increased expression of NCR3LG1 protein CTD PMID:32060585 NCBI chr 1:102,078,274...102,093,495 JBrowse link
G Ngf nerve growth factor multiple interactions EXP Promethazine inhibits the reaction [Capsaicin results in increased expression of NGF protein] CTD PMID:15265675 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Pgam1 phosphoglycerate mutase 1 increases expression EXP Promethazine results in increased expression of PGAM1 mRNA CTD PMID:28903497 NCBI chr 1:261,158,204...261,165,814
Ensembl chr 1:261,158,261...261,165,808
JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression EXP Promethazine results in decreased expression of PKM mRNA CTD PMID:28903497 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Plk1 polo-like kinase 1 decreases expression EXP Promethazine results in decreased expression of PLK1 mRNA CTD PMID:26011634 NCBI chr 1:192,115,990...192,125,969
Ensembl chr 1:192,115,966...192,125,989
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Promethazine results in increased expression of PMAIP1 protein CTD PMID:31682805 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Rad17 RAD17 checkpoint clamp loader component decreases expression EXP Promethazine results in decreased expression of RAD17 mRNA CTD PMID:26011634 NCBI chr 2:30,634,353...30,664,618
Ensembl chr 2:30,634,354...30,664,163
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression EXP Promethazine results in decreased expression of RB1 mRNA CTD PMID:26011634 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 decreases expression EXP Promethazine results in decreased expression of RBL2 mRNA CTD PMID:26011634, PMID:26558467 NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Promethazine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Promethazine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine] CTD PMID:19821448 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression EXP Promethazine results in decreased expression of SLC2A1 mRNA CTD PMID:28903497 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression EXP Promethazine results in decreased expression of SLC2A2 mRNA CTD PMID:28903497 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Promethazine results in increased expression of SQSTM1 protein CTD PMID:31682805 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Promethazine results in increased expression of TNF protein CTD PMID:15265675 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases activity ISO Promethazine results in decreased activity of TNFSF11 CTD PMID:21869564 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Top2a DNA topoisomerase II alpha affects expression EXP Promethazine affects the expression of TOP2A protein CTD PMID:26011634 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Promethazine results in decreased expression of TP53 mRNA CTD PMID:26011634 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ubd ubiquitin D decreases expression EXP Promethazine results in decreased expression of UBD protein CTD PMID:26011634 NCBI chr20:1,876,175...1,878,126
Ensembl chr20:1,876,173...1,897,814
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases expression ISO Promethazine results in increased expression of ULK1 protein CTD PMID:31682805 NCBI chr12:51,908,105...51,934,704
Ensembl chr12:51,908,448...51,934,702
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          antiviral agent 10245
            anticoronaviral agent 8940
              promethazine 59
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        tertiary amino compound 8629
                                          tertiary amine 616
                                            promethazine 59
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