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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:promethazine
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Accession:CHEBI:8461 term browser browse the term
Definition:A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
Synonyms:exact_synonym: N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
 related_synonym: (2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine;   10-(2-Dimethylaminopropyl)phenothiazine;   10-[2-(dimethylamino)propyl]phenothiazine;   Formula=C17H20N2S;   InChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3;   InChIKey=PWWVAXIEGOYWEE-UHFFFAOYSA-N;   N,N,alpha-trimethyl-10H-phenothiazine-10-ethanamine;   N-(2'-dimethylamino-2'-methyl)ethylphenothiazine;   SMILES=CC(CN1c2ccccc2Sc2ccccc12)N(C)C;   proazamine;   prometazina;   promethazinum
 xref: Beilstein:88554;   CAS:60-87-7;   DrugBank:DB01069;   Drug_Central:2286;   Gmelin:337077;   HMDB:HMDB0015202;   KEGG:C07404;   KEGG:D00494;   LINCS:LSM-4440
 xref_mesh: MESH:D011398
 xref: Patent:US2530451;   Patent:US2607773;   Reaxys:88554;   Wikipedia:Promethazine
 cyclic_relationship: is_conjugate_base_of CHEBI:61214


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promethazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambra1 autophagy and beclin 1 regulator 1 decreases expression ISO Promethazine results in decreased expression of AMBRA1 protein CTD PMID:31682805 NCBI chr 3:77,700,936...77,890,221
Ensembl chr 3:77,700,936...77,890,221
JBrowse link
G Atg5 autophagy related 5 decreases expression ISO Promethazine results in decreased expression of ATG5 protein CTD PMID:31682805 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atg7 autophagy related 7 decreases expression ISO Promethazine results in decreased expression of ATG7 protein CTD PMID:31682805 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Atm ATM serine/threonine kinase decreases expression EXP Promethazine results in decreased expression of ATM mRNA CTD PMID:26011634 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression EXP Promethazine results in decreased expression of ATP5F1B mRNA CTD PMID:28903497 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
JBrowse link
G Aurka aurora kinase A decreases expression EXP Promethazine results in decreased expression of AURKA mRNA CTD PMID:26011634 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Aurkb aurora kinase B decreases expression EXP Promethazine results in decreased expression of AURKB mRNA CTD PMID:26011634 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Promethazine results in increased expression of BAK1 protein CTD PMID:31682805 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO
EXP
Promethazine results in decreased activity of BCHE protein CTD PMID:236606 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Promethazine results in decreased expression of BCL2 protein CTD PMID:31682805 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Promethazine results in decreased expression of BCL2L1 protein CTD PMID:31682805 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Becn1 beclin 1 multiple interactions ISO Promethazine affects the expression of and results in increased phosphorylation of BECN1 protein CTD PMID:31682805 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression EXP Promethazine results in decreased expression of BRCA1 mRNA CTD PMID:26011634 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Brca2 BRCA2, DNA repair associated decreases expression EXP Promethazine results in decreased expression of BRCA2 mRNA CTD PMID:26011634 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 decreases expression EXP Promethazine results in decreased expression of BRCC3 mRNA CTD PMID:26011634 NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression EXP Promethazine results in decreased expression of BUB1 mRNA CTD PMID:26011634 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
JBrowse link
G Casp3 caspase 3 decreases cleavage EXP Promethazine results in decreased cleavage of CASP3 protein CTD PMID:26011634 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
increases phosphorylation
decreases expression
EXP Promethazine results in increased expression of CDKN1A protein
Promethazine results in increased phosphorylation of CDKN1A protein
Promethazine results in decreased expression of CDKN1A mRNA
CTD PMID:26011634 PMID:26558467 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression EXP Promethazine results in decreased expression of CDKN2A mRNA CTD PMID:26011634 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Chek1 checkpoint kinase 1 increases expression
decreases expression
EXP Promethazine results in increased expression of CHEK1 mRNA
Promethazine results in decreased expression of CHEK1 mRNA
CTD PMID:26011634 PMID:26558467 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chek2 checkpoint kinase 2 decreases expression EXP Promethazine results in decreased expression of CHEK2 mRNA CTD PMID:26011634 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases metabolic processing ISO CYP2D6 gene polymorphism results in decreased metabolism of Promethazine CTD PMID:19814645 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Esco1 establishment of sister chromatid cohesion N-acetyltransferase 1 decreases expression EXP Promethazine results in decreased expression of ESCO1 mRNA CTD PMID:26011634 NCBI chr18:1,630,560...1,686,803
Ensembl chr18:1,631,954...1,686,942
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression EXP Promethazine results in increased expression of G6PD mRNA CTD PMID:28903497 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression EXP Promethazine affects the expression of GADD45A mRNA CTD PMID:26011634 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression EXP Promethazine results in decreased expression of GAPDH mRNA CTD PMID:28903497 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G H2ax H2A.X variant histone decreases expression EXP Promethazine results in decreased expression of H2AX protein CTD PMID:26011634 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression EXP Promethazine results in decreased expression of HIF1A mRNA CTD PMID:28903497 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hk2 hexokinase 2 decreases expression EXP Promethazine results in decreased expression of HK2 mRNA CTD PMID:28903497 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO Promethazine binds to and results in decreased activity of HRH1 protein; Promethazine binds to and results in increased activity of HRH1 protein; Promethazine inhibits the reaction [Pyrilamine binds to HRH1 protein] CTD PMID:1377455 PMID:1912125 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions ISO Promethazine binds to and results in decreased activity of HRH2 protein CTD PMID:1377455 NCBI chr17:10,368,355...10,407,791
Ensembl chr17:10,368,298...10,407,631
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Promethazine results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Promethazine results in increased expression of IL1B protein CTD PMID:15265675 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression EXP Promethazine results in increased expression of IL6 protein CTD PMID:15265675 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 decreases expression EXP Promethazine results in decreased expression of MAD1L1 mRNA CTD PMID:26011634 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 increases expression
decreases expression
EXP Promethazine results in increased expression of MAD2L1 mRNA
Promethazine results in decreased expression of MAD2L1 mRNA
CTD PMID:26011634 PMID:26558467 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Promethazine results in decreased expression of MCL1 protein CTD PMID:31682805 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mdm2 MDM2 proto-oncogene increases phosphorylation EXP Promethazine results in increased phosphorylation of MDM2 protein CTD PMID:26558467 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression
affects expression
EXP Promethazine results in increased expression of MKI67 protein
Promethazine affects the expression of MKI67 protein
CTD PMID:26011634 PMID:26558467 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO Promethazine results in decreased expression of and results in decreased phosphorylation of MTOR protein CTD PMID:31682805 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression EXP Promethazine results in decreased expression of MYC mRNA CTD PMID:28903497 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ncr3lg1 natural killer cell cytotoxicity receptor 3 ligand 1 increases expression ISO Promethazine results in increased expression of NCR3LG1 mRNA; Promethazine results in increased expression of NCR3LG1 protein CTD PMID:32060585 NCBI chr 1:96,565,664...96,581,825 JBrowse link
G Ngf nerve growth factor multiple interactions EXP Promethazine inhibits the reaction [Capsaicin results in increased expression of NGF protein] CTD PMID:15265675 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Pgam1 phosphoglycerate mutase 1 increases expression EXP Promethazine results in increased expression of PGAM1 mRNA CTD PMID:28903497 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Promethazine results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression EXP Promethazine results in decreased expression of PKM mRNA CTD PMID:28903497 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Plk1 polo-like kinase 1 decreases expression EXP Promethazine results in decreased expression of PLK1 mRNA CTD PMID:26011634 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Promethazine results in increased expression of PMAIP1 protein CTD PMID:31682805 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Rad17 RAD17 checkpoint clamp loader component decreases expression EXP Promethazine results in decreased expression of RAD17 mRNA CTD PMID:26011634 NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression EXP Promethazine results in decreased expression of RB1 mRNA CTD PMID:26011634 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 decreases expression EXP Promethazine results in decreased expression of RBL2 mRNA CTD PMID:26011634 PMID:26558467 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Promethazine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Promethazine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine] CTD PMID:19821448 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression EXP Promethazine results in decreased expression of SLC2A1 mRNA CTD PMID:28903497 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression EXP Promethazine results in decreased expression of SLC2A2 mRNA CTD PMID:28903497 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Promethazine results in increased expression of SQSTM1 protein CTD PMID:31682805 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO Promethazine results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Promethazine results in increased expression of TNF protein CTD PMID:15265675 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases activity ISO Promethazine results in decreased activity of TNFSF11 CTD PMID:21869564 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Top2a DNA topoisomerase II alpha affects expression EXP Promethazine affects the expression of TOP2A protein CTD PMID:26011634 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Promethazine results in decreased expression of TP53 mRNA CTD PMID:26011634 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ubd ubiquitin D decreases expression EXP Promethazine results in decreased expression of UBD protein CTD PMID:26011634 NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases expression ISO Promethazine results in increased expression of ULK1 protein CTD PMID:31682805 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link

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  CHEBI ontology 19812
    role 19761
      biological role 19761
        antimicrobial agent 17400
          antiviral agent 10293
            anticoronaviral agent 9003
              promethazine 62
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        tertiary amino compound 8677
                                          tertiary amine 619
                                            promethazine 62
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