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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:promazine
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Accession:CHEBI:8459 term browser browse the term
Definition:A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.
Synonyms:exact_synonym: N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine
 related_synonym: 10-(3-(Dimethylamino)propyl)phenothiazine;   Formula=C17H20N2S;   InChI=1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3;   InChIKey=ZGUGWUXLJSTTMA-UHFFFAOYSA-N;   N-(3-Dimethylaminopropyl)phenothiazine;   N-Dimethylamino-1-methylethyl thiodiphenylamine;   SMILES=CN(C)CCCN1c2ccccc2Sc2ccccc12;   promazina;   promazinum
 xref: Beilstein:244925;   CAS:58-40-2;   DrugBank:DB00420;   Drug_Central:2284;   HMDB:HMDB0014564;   KEGG:C07379;   KEGG:D08430;   LINCS:LSM-2137
 xref_mesh: MESH:D011395
 xref: PMID:1650428;   PMID:18423639;   PMID:19306624;   PMID:20825390;   Patent:US2519886;   Reaxys:244925;   Wikipedia:Promazine



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promazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO Promazine results in decreased activity of BCHE protein CTD PMID:236606 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Promazine results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Promazine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Promazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      application 19486
        pharmaceutical 19335
          drug 19335
            antiemetic 5160
              promazine 4
                promazine hydrochloride 0
                promazine sulfoxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    main group molecular entity 19720
                      s-block molecular entity 19502
                        hydrogen molecular entity 19495
                          hydrides 18855
                            inorganic hydride 17694
                              pnictogen hydride 17675
                                nitrogen hydride 17547
                                  azane 17280
                                    ammonia 17279
                                      organic amino compound 17279
                                        tertiary amino compound 8687
                                          tertiary amine 620
                                            promazine 4
                                              promazine hydrochloride 0
                                              promazine sulfoxide 0
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