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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:8459 term browser browse the term
Definition:A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.
Synonyms:exact_synonym: N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine
 related_synonym: 10-(3-(Dimethylamino)propyl)phenothiazine;   Formula=C17H20N2S;   InChI=1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3;   InChIKey=ZGUGWUXLJSTTMA-UHFFFAOYSA-N;   N-(3-Dimethylaminopropyl)phenothiazine;   N-Dimethylamino-1-methylethyl thiodiphenylamine;   SMILES=CN(C)CCCN1c2ccccc2Sc2ccccc12;   promazina;   promazinum
 xref: Beilstein:244925;   CAS:58-40-2;   DrugBank:DB00420;   Drug_Central:2284;   HMDB:HMDB0014564;   KEGG:C07379;   KEGG:D08430;   LINCS:LSM-2137
 xref_mesh: MESH:D011395
 xref: PMID:1650428;   PMID:18423639;   PMID:19306624;   PMID:20825390;   Patent:US2519886;   Reaxys:244925;   Wikipedia:Promazine

show annotations for term's descendants           Sort by:
promazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO Promazine results in decreased activity of BCHE protein CTD PMID:236606 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Promazine results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Promazine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Promazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        pharmaceutical 19293
          drug 19293
            antiemetic 5129
              promazine 4
                promazine hydrochloride 0
                promazine sulfoxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    main group molecular entity 19696
                      s-block molecular entity 19456
                        hydrogen molecular entity 19447
                          hydrides 18703
                            inorganic hydride 17433
                              pnictogen hydride 17405
                                nitrogen hydride 17247
                                  azane 16964
                                    ammonia 16963
                                      organic amino compound 16962
                                        tertiary amino compound 8638
                                          tertiary amine 617
                                            promazine 4
                                              promazine hydrochloride 0
                                              promazine sulfoxide 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.