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ONTOLOGY REPORT - ANNOTATIONS


Term:trifluoperazine
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Accession:CHEBI:45951 term browser browse the term
Definition:A member of the class of phenothiazines that is phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.
Synonyms:related_synonym: 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE;   10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine;   10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine;   Formula=C21H24F3N3S;   InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3;   InChIKey=ZEWQUBUPAILYHI-UHFFFAOYSA-N;   SMILES=CN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1;   trifluoperazina;   trifluoperazinum;   trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine;   trifluoroperazine;   trifluperazine
 alt_id: CHEBI:45949;   CHEBI:9709
 xref: Beilstein:57272 "Beilstein";   CAS:117-89-5 "ChemIDplus";   CAS:117-89-5 "KEGG COMPOUND";   CAS:117-89-5 "NIST Chemistry WebBook";   DrugBank:DB00831;   Drug_Central:2740 "DrugCentral";   Gmelin:2415561 "Gmelin";   HMDB:HMDB0014969;   KEGG:C07168;   KEGG:D08636;   LINCS:LSM-4010
 xref_mesh: MESH:D014268
 xref: PDBeChem:TFP;   PMID:11121417 "Europe PMC";   PMID:14974020 "Europe PMC";   PMID:15722405 "Europe PMC";   PMID:1650428 "Europe PMC";   PMID:19277699 "Europe PMC";   PMID:19747949 "Europe PMC";   PMID:20544963 "Europe PMC";   PMID:7404501 "Europe PMC";   PMID:9730919 "Europe PMC";   Reaxys:57272 "Reaxys";   Wikipedia:Trifluoperazine


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trifluoperazine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Atp6v1h ATPase H+ transporting V1 subunit H JBrowse link 5 14,262,352 14,367,898 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cd44 CD44 molecule (Indian blood group) JBrowse link 3 92,695,083 92,783,820 RGD:6480464
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:6480464
G Fmo2 flavin containing dimethylaniline monoxygenase 2 JBrowse link 13 80,752,526 80,775,264 RGD:6480464
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 JBrowse link 20 1,955,344 1,984,907 RGD:6480464
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 JBrowse link 5 62,276,100 62,621,737 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Kcnn2 potassium calcium-activated channel subfamily N member 2 JBrowse link 18 39,331,894 39,479,574 RGD:6480464
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 16 81,689,576 81,714,341 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6480464
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:6480464
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6480464
G Myl9 myosin light chain 9 JBrowse link 3 152,857,573 152,863,961 RGD:6480464
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:6480464
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:6480464
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464
G Rel REL proto-oncogene, NF-kB subunit JBrowse link 14 108,490,794 108,517,582 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G Slc5a6 solute carrier family 5 member 6 JBrowse link 6 26,685,823 26,697,110 RGD:6480464
G Tfeb transcription factor EB JBrowse link 9 15,208,141 15,264,101 RGD:6480464
G Tnfsf11 TNF superfamily member 11 JBrowse link 15 60,482,527 60,512,704 RGD:6480464
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 JBrowse link 9 95,256,628 95,302,822 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        pharmacological role 18687
          antagonist 15809
            calmodulin antagonist 67
              trifluoperazine 37
                trifluoperazine dimaleate 0
                trifluoperazine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    main group molecular entity 19539
                      s-block molecular entity 19322
                        hydrogen molecular entity 19312
                          hydrides 18241
                            inorganic hydride 17110
                              pnictogen hydride 17068
                                nitrogen hydride 16889
                                  azane 16565
                                    ammonia 16562
                                      organic amino compound 16561
                                        tertiary amino compound 8525
                                          N-alkylpiperazine 2956
                                            N-methylpiperazine 839
                                              trifluoperazine 37
                                                trifluoperazine dimaleate 0
                                                trifluoperazine hydrochloride 0
paths to the root

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