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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluphenazine
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Accession:CHEBI:5123 term browser browse the term
Definition:A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position.
Synonyms:exact_synonym: 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol
 related_synonym: 1-(2-hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine;   10-(3'-(4''-(beta-hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine;   10-(3-(2-hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine;   2-(4-(3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol;   2-(trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine;   4-(3-(-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol;   4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol;   4-(3-(2-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol;   Fluorfenazine;   Fluorophenazine;   Fluorphenazine;   Formula=C22H26F3N3OS;   InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2;   InChIKey=PLDUPXSUYLZYBN-UHFFFAOYSA-N;   SMILES=OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1;   Triflumethazine;   flufenazina;   fluphenazinum
 xref: Beilstein:1189506;   Beilstein:61643;   CAS:69-23-8;   DrugBank:DB00623;   Drug_Central:1212;   Gmelin:1231182;   HMDB:HMDB0014761;   KEGG:C07010;   KEGG:D07977;   LINCS:LSM-3226
 xref_mesh: MESH:D005476
 xref: PMID:13950763;   PMID:16117689;   PMID:1650428;   PMID:16839522;   PMID:25595294;   PMID:5128930;   Patent:GB829246;   Patent:GB833474;   Patent:US3058979;   Patent:US3194733;   Reaxys:61643;   Wikipedia:Fluphenazine


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fluphenazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase multiple interactions
decreases activity
EXP [Fluphenazine co-treated with diphenyldiselenide] results in decreased activity of ALAD protein
Fluphenazine results in decreased activity of ALAD protein
CTD PMID:19486337 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Ar androgen receptor multiple interactions ISO Fluphenazine binds to and results in decreased activity of AR protein CTD PMID:17606915 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cat catalase multiple interactions
increases activity
EXP diphenyldiselenide inhibits the reaction [Fluphenazine results in increased activity of CAT protein] CTD PMID:19486337 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity ISO Fluphenazine results in decreased activity of CYP2C9 protein CTD PMID:15135088 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO Fluphenazine results in decreased activity of CYP2C19 protein CTD PMID:15135088 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Fluphenazine results in decreased activity of CYP2E1 protein CTD PMID:15135088 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Fluphenazine results in decreased activity of CYP3A4 protein CTD PMID:15135088 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Drd2 dopamine receptor D2 affects binding ISO Fluphenazine binds to DRD2 protein CTD PMID:17606915 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects binding ISO Fluphenazine binds to HTR2A protein CTD PMID:17606915 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding ISO Fluphenazine binds to HTR2C protein CTD PMID:17606915 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Fluphenazine inhibits the reaction [NGF protein results in increased uptake of Calcium] CTD PMID:1374475 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Prl prolactin increases secretion ISO Fluphenazine results in increased secretion of PRL protein CTD PMID:9989566 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Fluphenazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression ISO Fluphenazine results in decreased expression of TAC1 mRNA CTD PMID:15845098 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tfeb transcription factor EB affects localization ISO Fluphenazine affects the localization of TFEB protein CTD PMID:28366621 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO
EXP
Fluphenazine results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        antimicrobial agent 17400
          antiviral agent 10293
            anticoronaviral agent 9003
              fluphenazine 16
                fluphenazine decanoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organic heteropolycyclic compound 18059
                                    organic heterotricyclic compound 14650
                                      mancude organic heterotricyclic parent 360
                                        phenothiazine 32
                                          10H-phenothiazine 32
                                            fluphenazine 16
                                              fluphenazine decanoate 0
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