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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluphenazine
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Accession:CHEBI:5123 term browser browse the term
Definition:A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position.
Synonyms:exact_synonym: 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol
 related_synonym: 1-(2-hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine;   10-(3'-(4''-(beta-hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine;   10-(3-(2-hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine;   2-(4-(3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol;   2-(trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine;   4-(3-(-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol;   4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol;   4-(3-(2-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol;   Fluorfenazine;   Fluorophenazine;   Fluorphenazine;   Formula=C22H26F3N3OS;   InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2;   InChIKey=PLDUPXSUYLZYBN-UHFFFAOYSA-N;   SMILES=OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1;   Triflumethazine;   flufenazina;   fluphenazinum
 xref: Beilstein:1189506;   Beilstein:61643;   CAS:69-23-8;   DrugBank:DB00623;   Drug_Central:1212;   Gmelin:1231182;   HMDB:HMDB0014761;   KEGG:C07010;   KEGG:D07977;   LINCS:LSM-3226
 xref_mesh: MESH:D005476
 xref: PMID:13950763;   PMID:16117689;   PMID:1650428;   PMID:16839522;   PMID:25595294;   PMID:5128930;   Patent:GB829246;   Patent:GB833474;   Patent:US3058979;   Patent:US3194733;   Reaxys:61643;   Wikipedia:Fluphenazine


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fluphenazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase multiple interactions
decreases activity
EXP [Fluphenazine co-treated with diphenyldiselenide] results in decreased activity of ALAD protein
Fluphenazine results in decreased activity of ALAD protein
CTD PMID:19486337 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Ar androgen receptor multiple interactions ISO Fluphenazine binds to and results in decreased activity of AR protein CTD PMID:17606915 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cat catalase multiple interactions
increases activity
EXP diphenyldiselenide inhibits the reaction [Fluphenazine results in increased activity of CAT protein] CTD PMID:19486337 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO Fluphenazine results in decreased activity of CYP2C19 protein CTD PMID:15135088 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Fluphenazine results in decreased activity of CYP2E1 protein CTD PMID:15135088 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Drd2 dopamine receptor D2 affects binding ISO Fluphenazine binds to DRD2 protein CTD PMID:17606915 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects binding ISO Fluphenazine binds to HTR2A protein CTD PMID:17606915 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding ISO Fluphenazine binds to HTR2C protein CTD PMID:17606915 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Fluphenazine inhibits the reaction [NGF protein results in increased uptake of Calcium] CTD PMID:1374475 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Prl prolactin increases secretion ISO Fluphenazine results in increased secretion of PRL protein CTD PMID:9989566 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Fluphenazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression ISO Fluphenazine results in decreased expression of TAC1 mRNA CTD PMID:15845098 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tfeb transcription factor EB affects localization ISO Fluphenazine affects the localization of TFEB protein CTD PMID:28366621 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          antiviral agent 10245
            anticoronaviral agent 8940
              fluphenazine 13
                fluphenazine decanoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17820
                                    organic heterotricyclic compound 14571
                                      mancude organic heterotricyclic parent 347
                                        phenothiazine 26
                                          10H-phenothiazine 26
                                            fluphenazine 13
                                              fluphenazine decanoate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.