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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:perazine
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Accession:CHEBI:59118 term browser browse the term
Definition:A phenothiazine derivative in which 10H-phenothiazinecarries a 3-(4-methylpiperazin-1-yl)propyl substituent at the N-10 position.
Synonyms:exact_synonym: 10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
 related_synonym: 10-(3-(4-Methyl-1-piperazinyl)propyl)-10H-phenothiazine;   Formula=C20H25N3S;   InChI=1S/C20H25N3S/c1-21-13-15-22(16-14-21)11-6-12-23-17-7-2-4-9-19(17)24-20-10-5-3-8-18(20)23/h2-5,7-10H,6,11-16H2,1H3;   InChIKey=WEYVCQFUGFRXOM-UHFFFAOYSA-N;   N-(3-(4-Methyl-1-piperazinyl)propyl)phenothiazine;   N-Methyl-piperazinyl-N'-propyl-phenothiazin;   N-Methyl-piperazinylpropyl-phenothiazine;   Pernazine;   SMILES=CN1CCN(CCCN2c3ccccc3Sc3ccccc23)CC1
 xref: Beilstein:39009;   CAS:84-97-9;   Drug_Central:2100;   Gmelin:298041;   KEGG:C16903
 xref_mesh: MESH:D010464
 xref: PMID:1650428;   PMID:19904008;   PMID:23479940;   PMID:24425538;   Patent:GB780193;   Reaxys:39009;   Wikipedia:Perazine


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perazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases oxidation ISO FMO3 protein results in increased oxidation of Perazine CTD PMID:11026737 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
thiethylperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        pharmacological role 18825
          neurotransmitter agent 16439
            dopaminergic agent 5082
              dopaminergic antagonist 1185
                perazine 3
                  thiethylperazine + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            inorganic hydride 17430
                              pnictogen hydride 17402
                                nitrogen hydride 17243
                                  azane 16960
                                    ammonia 16959
                                      organic amino compound 16958
                                        tertiary amino compound 8643
                                          N-alkylpiperazine 3079
                                            N-methylpiperazine 851
                                              perazine 3
                                                thiethylperazine + 2
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