CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: perazine
Accession: CHEBI:59118
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Definition: A phenothiazine derivative in which 10H-phenothiazinecarries a 3-(4-methylpiperazin-1-yl)propyl substituent at the N-10 position.
Synonyms: exact_synonym: 10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
related_synonym: 10-(3-(4-Methyl-1-piperazinyl)propyl)-10H-phenothiazine; Formula=C20H25N3S; InChI=1S/C20H25N3S/c1-21-13-15-22(16-14-21)11-6-12-23-17-7-2-4-9-19(17)24-20-10-5-3-8-18(20)23/h2-5,7-10H,6,11-16H2,1H3; InChIKey=WEYVCQFUGFRXOM-UHFFFAOYSA-N; N-(3-(4-Methyl-1-piperazinyl)propyl)phenothiazine; N-Methyl-piperazinyl-N'-propyl-phenothiazin; N-Methyl-piperazinylpropyl-phenothiazine; Pernazine; SMILES=CN1CCN(CCCN2c3ccccc3Sc3ccccc23)CC1
xref: Beilstein:39009; CAS:84-97-9; Drug_Central:2100; Gmelin:298041; KEGG:C16903
xref_mesh: MESH:D010464
xref: PMID:1650428; PMID:19904008; PMID:23479940; PMID:24425538; Patent:GB780193; Reaxys:39009; Wikipedia:Perazine
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases methylation
ISO
CYP3A4 protein results in decreased methylation of Perazine
CTD
PMID:11026737
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Fmo3
flavin containing dimethylaniline monoxygenase 3
increases oxidation
ISO
FMO3 protein results in increased oxidation of Perazine
CTD
PMID:11026737
NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
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Abcc1
ATP binding cassette subfamily C member 1
multiple interactions
ISO
[Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein
CTD
PMID:21881209
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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App
amyloid beta precursor protein
multiple interactions
ISO
[Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein
CTD
PMID:21881209
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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