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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:periciazine
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Accession:CHEBI:31981 term browser browse the term
Definition:A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic.
Synonyms:exact_synonym: 10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile
 related_synonym: 10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile;   2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine;   2-Cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine;   Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine;   Formula=C21H23N3OS;   InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2;   InChIKey=LUALIOATIOESLM-UHFFFAOYSA-N;   Piperocyanomazine;   Propericiazine;   SMILES=OC1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C#N)CC1;   periciazina;   periciazinum
 xref: Beilstein:576739;   CAS:2622-26-6;   DrugBank:DB01608;   Drug_Central:2107;   HMDB:HMDB0015546;   KEGG:D01485;   LINCS:LSM-24971
 xref_mesh: MESH:C084584
 xref: PMID:10441864;   PMID:16454538;   PMID:17606915;   PMID:27062;   PMID:5981335;   PMID:8562516;   PMID:9591093;   Patent:FR1212031;   Reaxys:576739;   Wikipedia:Periciazine



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periciazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO periciazine binds to and results in decreased activity of AR protein CTD PMID:17606915 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO periciazine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    chemical entity 20055
      group 19986
        pseudohalo group 3902
          cyano group 3902
            nitrile 3902
              periciazine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                organic heterocyclic compound 18798
                                  organic heteropolycyclic compound 18272
                                    organic heterotricyclic compound 15596
                                      mancude organic heterotricyclic parent 359
                                        phenothiazine 30
                                          10H-phenothiazine 30
                                            periciazine 2
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