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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:periciazine
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Accession:CHEBI:31981 term browser browse the term
Definition:A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic.
Synonyms:exact_synonym: 10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile
 related_synonym: 10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile;   2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine;   2-Cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine;   Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine;   Formula=C21H23N3OS;   InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2;   InChIKey=LUALIOATIOESLM-UHFFFAOYSA-N;   Piperocyanomazine;   Propericiazine;   SMILES=OC1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C#N)CC1;   periciazina;   periciazinum
 xref: Beilstein:576739;   CAS:2622-26-6;   DrugBank:DB01608;   Drug_Central:2107;   HMDB:HMDB0015546;   KEGG:D01485;   LINCS:LSM-24971
 xref_mesh: MESH:C084584
 xref: PMID:10441864;   PMID:16454538;   PMID:17606915;   PMID:27062;   PMID:5981335;   PMID:8562516;   PMID:9591093;   Patent:FR1212031;   Reaxys:576739;   Wikipedia:Periciazine


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periciazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO periciazine binds to and results in decreased activity of AR protein CTD PMID:17606915 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO periciazine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      group 19733
        pseudohalo group 3489
          cyano group 3489
            nitrile 3489
              periciazine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organic heteropolycyclic compound 18059
                                    organic heterotricyclic compound 14650
                                      mancude organic heterotricyclic parent 360
                                        phenothiazine 32
                                          10H-phenothiazine 32
                                            periciazine 2
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