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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:periciazine
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Accession:CHEBI:31981 term browser browse the term
Definition:A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic.
Synonyms:exact_synonym: 10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile
 related_synonym: 10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile;   2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine;   2-Cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine;   Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine;   Formula=C21H23N3OS;   InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2;   InChIKey=LUALIOATIOESLM-UHFFFAOYSA-N;   Piperocyanomazine;   Propericiazine;   SMILES=OC1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C#N)CC1;   periciazina;   periciazinum
 xref: Beilstein:576739;   CAS:2622-26-6;   DrugBank:DB01608;   Drug_Central:2107;   HMDB:HMDB0015546;   KEGG:D01485;   LINCS:LSM-24971
 xref_mesh: MESH:C084584
 xref: PMID:10441864;   PMID:16454538;   PMID:17606915;   PMID:27062;   PMID:5981335;   PMID:8562516;   PMID:9591093;   Patent:FR1212031;   Reaxys:576739;   Wikipedia:Periciazine


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periciazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO periciazine binds to and results in decreased activity of AR protein CTD PMID:17606915 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO periciazine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      group 19696
        pseudohalo group 2881
          cyano group 2881
            nitrile 2881
              periciazine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17820
                                    organic heterotricyclic compound 14571
                                      mancude organic heterotricyclic parent 347
                                        phenothiazine 26
                                          10H-phenothiazine 26
                                            periciazine 2
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