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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:perazine
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Accession:CHEBI:59118 term browser browse the term
Definition:A phenothiazine derivative in which 10H-phenothiazinecarries a 3-(4-methylpiperazin-1-yl)propyl substituent at the N-10 position.
Synonyms:exact_synonym: 10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
 related_synonym: 10-(3-(4-Methyl-1-piperazinyl)propyl)-10H-phenothiazine;   Formula=C20H25N3S;   InChI=1S/C20H25N3S/c1-21-13-15-22(16-14-21)11-6-12-23-17-7-2-4-9-19(17)24-20-10-5-3-8-18(20)23/h2-5,7-10H,6,11-16H2,1H3;   InChIKey=WEYVCQFUGFRXOM-UHFFFAOYSA-N;   N-(3-(4-Methyl-1-piperazinyl)propyl)phenothiazine;   N-Methyl-piperazinyl-N'-propyl-phenothiazin;   N-Methyl-piperazinylpropyl-phenothiazine;   Pernazine;   SMILES=CN1CCN(CCCN2c3ccccc3Sc3ccccc23)CC1
 xref: Beilstein:39009;   CAS:84-97-9;   Drug_Central:2100;   Gmelin:298041;   KEGG:C16903
 xref_mesh: MESH:D010464
 xref: PMID:1650428;   PMID:19904008;   PMID:23479940;   PMID:24425538;   Patent:GB780193;   Reaxys:39009;   Wikipedia:Perazine



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perazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases methylation ISO CYP3A4 protein results in decreased methylation of Perazine CTD PMID:11026737 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases oxidation ISO FMO3 protein results in increased oxidation of Perazine CTD PMID:11026737 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
thiethylperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      biological role 19633
        inhibitor 18659
          ferroptosis inhibitor 7473
            10H-phenothiazine 31
              perazine 4
                thiethylperazine + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    main group molecular entity 19649
                      s-block molecular entity 19457
                        hydrogen molecular entity 19450
                          hydrides 18928
                            inorganic hydride 17765
                              pnictogen hydride 17748
                                nitrogen hydride 17633
                                  azane 17403
                                    ammonia 17402
                                      organic amino compound 17402
                                        tertiary amino compound 9087
                                          N-alkylpiperazine 3353
                                            N-methylpiperazine 1191
                                              perazine 4
                                                thiethylperazine + 2
paths to the root