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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:perazine
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Accession:CHEBI:59118 term browser browse the term
Definition:A phenothiazine derivative in which 10H-phenothiazinecarries a 3-(4-methylpiperazin-1-yl)propyl substituent at the N-10 position.
Synonyms:exact_synonym: 10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
 related_synonym: 10-(3-(4-Methyl-1-piperazinyl)propyl)-10H-phenothiazine;   Formula=C20H25N3S;   InChI=1S/C20H25N3S/c1-21-13-15-22(16-14-21)11-6-12-23-17-7-2-4-9-19(17)24-20-10-5-3-8-18(20)23/h2-5,7-10H,6,11-16H2,1H3;   InChIKey=WEYVCQFUGFRXOM-UHFFFAOYSA-N;   N-(3-(4-Methyl-1-piperazinyl)propyl)phenothiazine;   N-Methyl-piperazinyl-N'-propyl-phenothiazin;   N-Methyl-piperazinylpropyl-phenothiazine;   Pernazine;   SMILES=CN1CCN(CCCN2c3ccccc3Sc3ccccc23)CC1
 xref: Beilstein:39009;   CAS:84-97-9;   Drug_Central:2100;   Gmelin:298041;   KEGG:C16903
 xref_mesh: MESH:D010464
 xref: PMID:1650428;   PMID:19904008;   PMID:23479940;   PMID:24425538;   Patent:GB780193;   Reaxys:39009;   Wikipedia:Perazine


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perazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases methylation ISO CYP3A4 protein results in decreased methylation of Perazine CTD PMID:11026737 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases oxidation ISO FMO3 protein results in increased oxidation of Perazine CTD PMID:11026737 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
thiethylperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        inhibitor 18592
          ferroptosis inhibitor 7515
            10H-phenothiazine 31
              perazine 4
                thiethylperazine + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        tertiary amino compound 8679
                                          N-alkylpiperazine 3104
                                            N-methylpiperazine 866
                                              perazine 4
                                                thiethylperazine + 2
paths to the root