Lamp1 (lysosomal-associated membrane protein 1)

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Gene: Lamp1 (lysosomal-associated membrane protein 1) Rattus norvegicus

Analyze

Symbol:

Lamp1

Name:

lysosomal-associated membrane protein 1

RGD ID:

2989

Description:

Predicted to enable enzyme binding activity and protein domain specific binding activity. Involved in autophagic cell death. Located in several cellular components, including cytoplasmic vesicle; lysosome; and neuronal cell body. Is active in synaptic vesicle membrane. Orthologous to human LAMP1 (lysosomal associated membrane protein 1); PARTICIPATES IN autophagy pathway; phagocytosis pathway; tuberculosis pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

120 kDa lysosomal membrane glycoprotein; CD107 antigen-like family member A; LAMP-1; LGP-120; LGP120; Lysosomal associated membrane protein 1 (120 kDa); lysosomal membrane glycoprotein 1; lysosome-associated membrane glycoprotein 1; lysosome-associated membrane protein 1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LAMP1 (lysosomal associated membrane protein 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Lamp1 (lysosomal-associated membrane protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lamp1 (lysosomal associated membrane protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LAMP1 (lysosomal associated membrane protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LAMP1 (lysosomal associated membrane protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lamp1 (lysosomal associated membrane protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LAMP1 (lysosomal associated membrane protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LAMP1 (lysosomal associated membrane protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lamp1 (lysosomal associated membrane protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Lamp1 (lysosomal-associated membrane protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	LAMP1 (lysosomal associated membrane protein 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Lamp1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	lmp-2	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Danio rerio (zebrafish):	lamp1b	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	lamp1a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	76,355,982 - 76,380,700 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	76,355,984 - 76,381,883 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	81,636,784 - 81,653,472 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	16	85,089,361 - 85,106,049 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	16	80,324,785 - 80,354,680 (-)	NCBI	Rnor_WKY
Rnor_6.0	16	81,689,576 - 81,714,341 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	81,689,335 - 81,714,419 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	81,175,574 - 81,200,580 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	81,213,165 - 81,230,019 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	81,213,425 - 81,230,284 (-)	NCBI
Celera	16	74,162,536 - 74,179,021 (-)	NCBI		Celera
RH 3.4 Map	16	744.4	RGD
Cytogenetic Map	16	q12.5	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

factor X deficiency (ISO)

genetic disease (ISO)

Streptococcus pneumonia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (EXP)

1,2-dimethylhydrazine (ISO)

1,3-dichloropropan-2-ol (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

3',5'-cyclic AMP (EXP)

3-chloropropane-1,2-diol (ISO)

3-methyladenine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxynon-2-enal (ISO)

aconitine (EXP)

acrolein (EXP)

acrylamide (ISO)

aldehydo-D-glucose (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antimycin A (ISO)

Aroclor 1254 (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

biotin (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

Brusatol (EXP)

cadmium atom (EXP,ISO)

cadmium dichloride (EXP,ISO)

cannabidiol (ISO)

captan (ISO)

carbamazepine (EXP)

carbon disulfide (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

CHIR 99021 (ISO)

chloropicrin (ISO)

cholesterol (ISO)

clofibrate (ISO)

clozapine (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) chloride (ISO)

coumestrol (ISO)

Cuprizon (ISO)

curcumin (EXP)

D-glucose (EXP)

decabromodiphenyl ether (EXP)

deguelin (ISO)

dexamethasone (EXP)

diarsenic trioxide (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

ethanol (EXP,ISO)

ferric oxide (EXP)

flunarizine (EXP)

flusilazole (EXP)

folic acid (ISO)

folpet (ISO)

formaldehyde (ISO)

fumonisin B1 (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

glucose (EXP)

ionomycin (ISO)

isoniazide (ISO)

ivermectin (ISO)

lead diacetate (ISO)

lead nitrate (ISO)

lipopolysaccharide (ISO)

methamphetamine (EXP,ISO)

methyl methanesulfonate (ISO)

Methylazoxymethanol acetate (EXP)

Mibefradil (EXP)

microcystin-LR (ISO)

mirtazapine (EXP)

N-acetyl-L-cysteine (EXP,ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

NADP zwitterion (ISO)

NADP(+) (ISO)

oligomycin A (ISO)

paraquat (ISO)

phenobarbital (EXP)

phenylpropanolamine (ISO)

phosphoramide mustard (EXP)

picoxystrobin (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

pterostilbene (ISO)

pyrroloquinoline quinone (ISO)

resveratrol (EXP)

rotenone (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

streptozocin (EXP)

sulindac sulfide (ISO)

sunitinib (ISO)

taurine (ISO)

tebufenpyrad (ISO)

temozolomide (ISO)

thapsigargin (EXP)

trichloroethene (EXP)

trifluoperazine (ISO)

valproic acid (ISO)

vitamin E (ISO)

Xanthatin (ISO)

Yessotoxin (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagic cell death (IDA)

establishment of protein localization to organelle (IEA,ISO)

Golgi to lysosome transport (IEA,ISO)

granzyme-mediated programmed cell death signaling pathway (IEA,ISO)

positive regulation of natural killer cell degranulation (IEA,ISO)

positive regulation of natural killer cell mediated cytotoxicity (ISO)

protein stabilization (IEA,ISO,ISS)

regulation of organelle transport along microtubule (IEA,ISO)

Cellular Component

alveolar lamellar body (IDA)

autolysosome (IEA,ISO)

autophagosome membrane (IEA,ISO)

cell surface (ISO)

cytolytic granule (ISO)

cytolytic granule membrane (IEA,ISO,ISS)

cytoplasm (ISO)

cytoplasmic vesicle (IDA)

cytosol (IEA)

dendrite (IDA)

endosome (ISO)

endosome membrane (IEA,ISS)

external side of plasma membrane (IEA,ISO)

late endosome (ISO)

late endosome membrane (IEA)

lysosomal membrane (IEA,ISS)

lysosome (IDA,ISO)

lysosome (ISO)

melanosome (IEA,ISO)

multivesicular body (IDA,IEA,ISO)

neuronal cell body (IDA)

perinuclear region of cytoplasm (IEA,ISO)

phagocytic vesicle (ISO)

phagolysosome membrane (IEA,ISO)

plasma membrane (ISO)

plasma membrane (ISS)

sarcolemma (IEA,ISO)

synaptic vesicle (IEA,ISO)

synaptic vesicle membrane (EXP,IDA)

vacuole (IDA)

vesicle (ISO)

Molecular Function

enzyme binding (IEA,ISO)

molecular_function (ND)

protein binding (ISO)

protein domain specific binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

autophagy pathway (IDA,ISO)

phagocytosis pathway (IEA)

tuberculosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation.	Adams LD, etal., Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2600-8.
2.	The natural cytotoxicity receptor 1 contribution to early clearance of Streptococcus pneumoniae and to natural killer-macrophage cross talk.	Elhaik-Goldman S, etal., PLoS One. 2011;6(8):e23472. doi: 10.1371/journal.pone.0023472. Epub 2011 Aug 22.
3.	Combined apoptosis and autophagy, the process that eliminates the oocytes of atretic follicles in immature rats.	Escobar ML, etal., Apoptosis. 2008 Oct;13(10):1253-66.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Isolation and sequencing of a cDNA clone encoding 107 kDa sialoglycoprotein in rat liver lysosomal membranes.	Himeno M, etal., FEBS Lett 1989 Feb 27;244(2):351-6.
7.	Derived protein sequence, oligosaccharides, and membrane insertion of the 120-kDa lysosomal membrane glycoprotein (lgp120): identification of a highly conserved family of lysosomal membrane glycoproteins.	Howe CL, etal., Proc Natl Acad Sci U S A 1988 Oct;85(20):7577-81.
8.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9.	The phosphoinositide 3-phosphatase MTMR2 interacts with PSD-95 and maintains excitatory synapses by modulating endosomal traffic.	Lee HW, etal., J Neurosci. 2010 Apr 21;30(16):5508-18. doi: 10.1523/JNEUROSCI.4283-09.2010.
10.	Overview of macroautophagy regulation in mammalian cells.	Mehrpour M, etal., Cell Res. 2010 Jul;20(7):748-62. Epub 2010 Jun 15.
11.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
12.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
14.	GOA pipeline	RGD automated data pipeline
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Comprehensive gene review and curation	RGD comprehensive gene curation
17.	A novel role for alpha-tocopherol transfer protein (alpha-TTP) in protecting against chloroquine toxicity.	Shichiri M, etal., J Biol Chem. 2012 Jan 20;287(4):2926-34. doi: 10.1074/jbc.M111.321281. Epub 2011 Dec 6.
18.	A dileucine motif and a cluster of acidic amino acids in the second cytoplasmic domain of the batten disease-related CLN3 protein are required for efficient lysosomal targeting.	Storch S, etal., J Biol Chem. 2004 Dec 17;279(51):53625-34. doi: 10.1074/jbc.M410930200. Epub 2004 Oct 5.
19.	Molecular anatomy of a trafficking organelle.	Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
20.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21.	Lamellar bodies of rat alveolar type 2 cells have late endosomal marker proteins on their limiting membranes.	Wasano K and Hirakawa Y, Histochemistry. 1994 Nov;102(5):329-35.
22.	Autophagy in the heart and liver during normal aging and calorie restriction.	Wohlgemuth SE, etal., Rejuvenation Res. 2007 Sep;10(3):281-92.

Additional References at PubMed

PMID:10787428	PMID:11182090	PMID:11266470	PMID:11486041	PMID:11854359	PMID:12446704	PMID:12925704	PMID:14506282	PMID:14627652	PMID:14643301	PMID:14668490	PMID:15006695
PMID:15052268	PMID:15073168	PMID:15292400	PMID:15294975	PMID:15588329	PMID:15613468	PMID:15792797	PMID:16415873	PMID:16542649	PMID:16674683	PMID:16973387	PMID:17620357
PMID:18388320	PMID:18477453	PMID:18767904	PMID:18787122	PMID:19056867	PMID:19915045	PMID:19946888	PMID:20956541	PMID:21266579	PMID:22190682	PMID:22641697	PMID:22792322
PMID:23376485	PMID:23395172	PMID:23533145	PMID:23632890	PMID:23704327	PMID:23926254	PMID:24029230	PMID:24035762	PMID:24841562	PMID:26284655	PMID:26329516	PMID:26432893
PMID:26965651	PMID:27466344	PMID:29273596	PMID:30922709	PMID:31006538	PMID:33450132

Genomics

Comparative Map Data

Lamp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	76,355,982 - 76,380,700 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	76,355,984 - 76,381,883 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	81,636,784 - 81,653,472 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	16	85,089,361 - 85,106,049 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	16	80,324,785 - 80,354,680 (-)	NCBI	Rnor_WKY
Rnor_6.0	16	81,689,576 - 81,714,341 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	81,689,335 - 81,714,419 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	81,175,574 - 81,200,580 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	81,213,165 - 81,230,019 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	81,213,425 - 81,230,284 (-)	NCBI
Celera	16	74,162,536 - 74,179,021 (-)	NCBI		Celera
RH 3.4 Map	16	744.4	RGD
Cytogenetic Map	16	q12.5	NCBI

LAMP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	113,297,239 - 113,323,672 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	13	113,297,239 - 113,323,672 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	113,951,554 - 113,977,987 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	112,999,470 - 113,025,742 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	13	112,999,602 - 113,025,741	NCBI
Celera	13	94,778,100 - 94,804,252 (+)	NCBI		Celera
Cytogenetic Map	13	q34	NCBI
HuRef	13	94,390,382 - 94,416,378 (+)	NCBI		HuRef
CHM1_1	13	113,920,516 - 113,946,732 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	13	112,550,907 - 112,577,228 (+)	NCBI		T2T-CHM13v2.0

Lamp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	13,209,161 - 13,225,338 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	13,209,161 - 13,225,338 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	13,159,161 - 13,175,338 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	13,159,161 - 13,175,338 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	13,159,135 - 13,175,338 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	13,159,256 - 13,175,315 (+)	NCBI		MGSCv36	mm8
Celera	8	13,327,454 - 13,343,657 (+)	NCBI		Celera
Cytogenetic Map	8	A1.1	NCBI
cM Map	8	5.73	NCBI

Lamp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955404	557,862 - 573,379 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955404	557,090 - 573,532 (-)	NCBI	ChiLan1.0	ChiLan1.0

LAMP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	13	113,507,400 - 113,530,179 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	113,507,401 - 113,530,457 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	13	94,442,507 - 94,464,061 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

LAMP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	60,678,116 - 60,695,619 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	60,678,111 - 60,694,924 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	60,390,142 - 60,407,645 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	61,363,372 - 61,380,853 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	61,304,300 - 61,380,844 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	60,802,204 - 60,819,682 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	60,804,391 - 60,821,868 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	60,835,472 - 60,852,955 (+)	NCBI		UU_Cfam_GSD_1.0

Lamp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	195,563,024 - 195,574,796 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936472	378,173 - 389,381 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936472	377,359 - 389,121 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LAMP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	78,600,713 - 78,617,615 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	78,600,818 - 78,617,587 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	86,117,963 - 86,134,737 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LAMP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	91,295,758 - 91,319,881 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	91,295,681 - 91,321,333 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666046	48,343,222 - 48,368,545 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lamp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624793	661,342 - 675,675 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624793	661,322 - 675,603 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Lamp1
72 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	434
Count of miRNA genes:	245
Interacting mature miRNAs:	287
Transcripts:	ENSRNOT00000026580
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
1578768	Stresp22	Stress response QTL 22	2.8		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	16	35288870	80288870	Rat
2293690	Bss45	Bone structure and strength QTL 45	5.13	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	16	37752156	82752156	Rat
2300163	Bmd64	Bone mineral density QTL 64	5.3	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	16	37752156	82752156	Rat
7205510	Activ5	Activity QTL 5	3.78	0.00028	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	42396345	84729064	Rat
8694429	Bw164	Body weight QTL 164	5	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	16	52726464	84729064	Rat
8694364	Abfw7	Abdominal fat weight QTL 7	12.22	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	16	52726464	84729064	Rat
7411648	Foco22	Food consumption QTL 22	15	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	52726464	84729064	Rat
631525	Pia14	Pristane induced arthritis QTL 14	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	16	55711087	83402471	Rat

Markers in Region

J03881

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	76,356,031 - 76,356,139 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	81,689,385 - 81,689,492	NCBI	Rnor6.0
Rnor_5.0	16	81,175,624 - 81,175,731	UniSTS	Rnor5.0
RGSC_v3.4	16	81,212,972 - 81,213,079	UniSTS	RGSC3.4
Celera	16	74,162,346 - 74,162,453	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

Lamp1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	76,356,028 - 76,356,561 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	81,689,382 - 81,689,913	NCBI	Rnor6.0
Rnor_5.0	16	81,175,621 - 81,176,152	UniSTS	Rnor5.0
RGSC_v3.4	16	81,212,969 - 81,213,499	UniSTS	RGSC3.4
Celera	16	74,162,343 - 74,162,873	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

RH142299

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	76,363,174 - 76,363,728 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	81,696,818 - 81,697,371	NCBI	Rnor6.0
Rnor_5.0	16	81,183,057 - 81,183,610	UniSTS	Rnor5.0
Celera	16	74,169,278 - 74,169,831	UniSTS
RH 3.4 Map	16	744.4	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

RH137106

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	76,357,622 - 76,357,812 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	81,690,975 - 81,691,164	NCBI	Rnor6.0
Rnor_5.0	16	81,177,214 - 81,177,403	UniSTS	Rnor5.0
RGSC_v3.4	16	81,214,561 - 81,214,750	UniSTS	RGSC3.4
Celera	16	74,163,935 - 74,164,124	UniSTS
RH 3.4 Map	16	743.2	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

BI282190

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	76,356,332 - 76,356,516 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	81,689,685 - 81,689,868	NCBI	Rnor6.0
Rnor_5.0	16	81,175,924 - 81,176,107	UniSTS	Rnor5.0
RGSC_v3.4	16	81,213,271 - 81,213,454	UniSTS	RGSC3.4
Celera	16	74,162,645 - 74,162,828	UniSTS
RH 3.4 Map	16	744.3	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

UniSTS:143756

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	76,355,996 - 76,356,148 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	81,689,350 - 81,689,501	NCBI	Rnor6.0
Rnor_5.0	16	81,175,589 - 81,175,740	UniSTS	Rnor5.0
RGSC_v3.4	16	81,212,937 - 81,213,088	UniSTS	RGSC3.4
Celera	16	74,162,311 - 74,162,462	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

UniSTS:224778

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	76,356,689 - 76,356,843 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	81,690,042 - 81,690,195	NCBI	Rnor6.0
Rnor_5.0	16	81,176,281 - 81,176,434	UniSTS	Rnor5.0
RGSC_v3.4	16	81,213,628 - 81,213,781	UniSTS	RGSC3.4
Celera	16	74,163,002 - 74,163,155	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221601	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221686	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	LC222322	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M34959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U75406	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X14765	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000026580 ⟹ ENSRNOP00000026580

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	76,355,984 - 76,381,467 (-)	Ensembl
Rnor_6.0 Ensembl	16	81,689,335 - 81,706,664 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000092248

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	81,697,315 - 81,697,985 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000092353 ⟹ ENSRNOP00000075799

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	81,690,613 - 81,693,000 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000092552 ⟹ ENSRNOP00000075832

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	76,355,984 - 76,381,883 (-)	Ensembl
Rnor_6.0 Ensembl	16	81,706,431 - 81,714,346 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000092722

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	81,713,614 - 81,714,419 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000096958 ⟹ ENSRNOP00000084480

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	76,355,984 - 76,372,770 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000105987 ⟹ ENSRNOP00000096531

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	76,355,984 - 76,366,679 (-)	Ensembl

RefSeq Acc Id:

NM_012857 ⟹ NP_036989

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	76,356,224 - 76,372,920 (-)	NCBI
Rnor_6.0	16	81,689,576 - 81,706,561 (-)	NCBI
Rnor_5.0	16	81,175,574 - 81,200,580 (-)	NCBI
RGSC_v3.4	16	81,213,165 - 81,230,019 (-)	RGD
Celera	16	74,162,536 - 74,179,021 (-)	RGD

Sequence:

show sequence

GCCGGCGCCGCAGCTGCCGGGCCTCTCGAGTCGGTGGACGCGCCCTCCCGCCGGCCTCGCCGCC
CGCGCAACCGCCGTCCTTCGGCCTCGGCTGCGTCGCGCCATGGCGGCCCCGGGCGCCCGGCGGC
CGCTGCTCCTGTTGCTGCTGGCAGGCCTTGCACACAGCGCCCCAGCACTGTTCGAGGTGAAAGA
CAACAACGGCACAGCGTGTATAATGGCCAGCTTCTCTGCCTCCTTTCTGACCACCTATGATGCT
GGACATGTTTCTAAGGTCTCGAATATGACCCTGCCAGCCTCTGCAGAAGTCCTGAAGAATAGCA
GCTCTTGTGGTGAAAAGAATGCTTCTGAGCCCACCCTCGCAATCACCTTTGGAGAAGGATATTT
ACTGAAACTCACCTTCACAAAAAACACAACACGTTACAGTGTCCAGCACATGTATTTCACATAT
AACCTGTCAGACACACAATTCTTTCCCAATGCCAGCTCCAAAGGGCCCGACACTGTGGATTCCA
CAACTGACATCAAGGCAGACATCAACAAAACATACCGATGTGTCAGCGACATCAGGGTCTACAT
GAAGAATGTGACCATTGTGCTCTGGGACGCTACTATCCAGGCCTACCTGCCGAGTAGCAACTTC
AGCAAGGAAGAGACACGCTGCCCACAGGATCAACCTTCCCCAACTACTGGGCCACCCAGCCCCT
CACCACCACTTGTGCCCACAAACCCCAGTGTGTCCAAGTACAATGTGACTGGTGACAATGGAAC
CTGCCTGCTGGCCTCTATGGCACTGCAACTCAACATCACCTACATGAAGAAGGACAACACGACT
GTGACCAGAGCATTCAACATCAACCCAAGTGACAAATATAGTGGGACTTGCGGTGCCCAGTTGG
TGACCCTGAAGGTGGGGAACAAGAGCAGAGTCCTGGAGCTGCAGTTTGGGATGAATGCCACTTC
TAGCCTGTTTTTCCTGCAAGGAGTTCAGTTGAACATGACTCTTCCTGATGCCATAGAGCCCACG
TTCAGCACCTCCAACTATTCCCTGAAAGCTCTTCAGGCCAGTGTCGGCAACTCATACAAGTGCA
ACAGTGAGGAGCACATCTTTGTCAGCAAGGCGCTCGCCCTCAATGTCTTCAGCGTGCAAGTCCA
GGCTTTCAGGGTAGAAAGTGACAGGTTTGGGTCTGTGGAAGAGTGTGTACAGGACGGTAACAAC
ATGCTGATCCCCATTGCTGTGGGCGGGGCCCTGGCAGGGCTGGTCCTCATCGTCCTCATCGCCT
ACCTCATCGGCAGGAAGAGGAGTCACGCGGGCTATCAGACCATCTAGCCTGGTGGGCAGGTGCG
CCACAGACGCACACGGGCCTGTTCTCACATCCCCAAGCTTAGATAGGTGTGGAAGGGAGGGAGG
CACACTTGTGGCAAACTGTTTTCAAATCTGCTTTATCAAATGTGAAGCTCATCTTGCAACATTT
ACTATGCACAAAGGAATAACTATTGAAATGACGGTGTTAATTTTGCTAACTGGGTTAAATATTT
TGCTAACTGGTTAAATGTTAATATGTTACCAAAGTAGAGCTCTAAAGAGGACAAGAAGGCTCCA
CGCATTTGACTTTTAAGACTTGGTGTTTGGTTCTTCATTCTTTTACTCAGATTTACGCCTTACA
AAGGGAATCTCTGGTCCAGACACTTGGGCCTGGCAAGGGTGGCTGATGGTGGTTAGGCTGCACA
CTTGAGAAGCAAACAGGAGCAGGGACGTCCTGCCACACAGGCACGCACAGGGTCAGCCTCTGGA
CACTTGGCTTGGGCTGCCTGGCCTGGGGGGCTAGACTCTGGCATCTGGCTGGGCACACCCACCA
GTGTTTCTGTGCTCTGCCGCCTGTGAGCTACCACTTTCCTAAATAGAAAATGGCATTATGGGGT
TGGGGATTTAGCTCAGTGGTAGAGCCCTTGCCTAGGAAGCGCAAGGCCCTGGGTTCGGTCCCCA
GCTCCGGAAAAAAAAAAAAGA

hide sequence

RefSeq Acc Id:

XM_017599994 ⟹ XP_017455483

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	76,355,982 - 76,380,700 (-)	NCBI
Rnor_6.0	16	81,689,963 - 81,714,341 (-)	NCBI

Sequence:

show sequence

TCTTTCCCTATTGCTGCGTTCCAGAGAAAAGTGCCTGGTTCCGTGTGGGGTGCTTGGGAAGAAA
CGAGCCCTGTGGCCCTGGCTTCTGTGGAACAGGCCAGGAAGCTCAACTGTAACAGGAGAGTGAT
GTAACAGGAAGATCTGACATCAGAAGAGGCTGGCGCAGAACACTCGGGAAAAGGACGGATGGCT
AAGCATCACGTGGCCTGGAGACCACGTGACGCCGATCGGCACGTGACACCATCACGAGCCAAGT
GGAGACTCCAGGAGAAGAGAGTAAGCGGCAGGCCGGCGGGCTCTCGCGAGACCCTCGGCTCACG
TGACCGGCGGGCGCGGCACTGTTCACGTGACAGGCGCTGCCGGCCGCAGGGTCTTCTCGGTGCC
GGCGCCGCAGCTGCCGGGCCTCTCGAGTCGGTGGACGCGCCCTCCCGCCGGCCTCGCCGCCCGC
GCAACCGCCGTCCTTCGGCCTCGGCTGCGTCGCGCCATGGCGGCCCCGGGCGCCCGGCGGCCGC
TGCTCCTGTTGCTGCTGGCAGGCCTTGCACACAGCGCCCCAGCACTGTTCGAGGTGAAAGACAA
CAACGGCACAGCGTGTATAATGGCCAGCTTCTCTGCCTCCTTTCTGACCACCTATGATGCTGGA
CATGTTTCTAAGGTCTCGAATATGACCCTGCCAGCCTCTGCAGAAGTCCTGAAGAATAGCAGCT
CTTGTGGTGAAAAGAATGCTTCTGAGCCCACCCTCGCAATCACCTTTGGAGAAGGATATTTACT
GAAACTCACCTTCACAAAAAACACAACACGTTACAGTGTCCAGCACATGTATTTCACATATAAC
CTGTCAGACACACAATTCTTTCCCAATGCCAGCTCCAAAGGGCCCGACACTGTGGATTCCACAA
CTGACATCAAGGCAGACATCAACAAAACATACCGATGTGTCAGCGACATCAGGGTCTACATGAA
GAATGTGACCATTGTGCTCTGGGACGCTACTATCCAGGCCTACCTGCCGAGTAGCAACTTCAGC
AAGGAAGAGACACGCTGCCCACAGGATCAACCTTCCCCAACTACTGGGCCACCCAGCCCCTCAC
CACCACTTGTGCCCACAAACCCCAGTGTGTCCAAGTACAATGTGACTGGTGACAATGGAACCTG
CCTGCTGGCCTCTATGGCACTGCAACTCAACATCACCTACATGAAGAAGGACAACACGACTGTG
ACCAGAGCATTCAACATCAACCCAAGTGACAAATATAGTGGGACTTGCGGTGCCCAGTTGGTGA
CCCTGAAGGTGGGGAACAAGAGCAGAGTCCTGGAGCTGCAGTTTGGGATGAATGCCACTTCTAG
CCTGTTTTTCCTGCAAGGAGTTCAGTTGAACATGACTCTTCCTGATGCCATAGAGCCCACGTTC
AGCACCTCCAACTATTCCCTGAAAGCTCTTCAGGCCAGTGTCGGCAACTCATACAAGTGCAACA
GTGAGGAGCACATCTTTGTCAGCAAGGCGCTCGCCCTCAATGTCTTCAGCGTGCAAGTCCAGGC
TTTCAGGGTAGAAAGTGACAGGTTTGGGTCTGTGGAAGAGTGTGTACAGGACGGTAACAACATG
CTGATCCCCATTGCTGTGGGCGGGGCCCTGGCAGGGCTGGTCCTCATCGTCCTCATCGCCTACC
TCATCGGCAGGAAGAGGAGTCACGCGGGCTATCAGACCATCTAGCCTGGTGGGCAGGTGCGCCA
CAGACGCACACGGGCCTGTTCTCACATCCCCAAGCTTAGATAGGTGTGGAAGGGAGGGAGGCAC
ACTTGTGGCAAACTGTTTTCAAATCTGCTTTATCAAATGTGAAGCTCATCTTGCAACATTTACT
ATGCACAAAGGAATAACTATTGAAATGACGGTGTTAATTTTGCTAACTGGGTTAAATATTTTGC
TAACTGGTTAAATGTTAATATGTTACCAAAGTAGAGCTCTAAAGAGGACAAGAAGGCTCCACGC
ATTTGACTTTTAAGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_036989	(Get FASTA)	NCBI Sequence Viewer
	XP_017455483	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41525	(Get FASTA)	NCBI Sequence Viewer
	AAB19108	(Get FASTA)	NCBI Sequence Viewer
	BBJ00845	(Get FASTA)	NCBI Sequence Viewer
	CAA32873	(Get FASTA)	NCBI Sequence Viewer
	EDM08878	(Get FASTA)	NCBI Sequence Viewer
	P14562	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_036989 ⟸ NM_012857
- Peptide Label:	precursor
- UniProtKB:	P97620 (UniProtKB/Swiss-Prot), P14562 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAAPGARRPLLLLLLAGLAHSAPALFEVKDNNGTACIMASFSASFLTTYDAGHVSKVSNMTLPA SAEVLKNSSSCGEKNASEPTLAITFGEGYLLKLTFTKNTTRYSVQHMYFTYNLSDTQFFPNASS KGPDTVDSTTDIKADINKTYRCVSDIRVYMKNVTIVLWDATIQAYLPSSNFSKEETRCPQDQPS PTTGPPSPSPPLVPTNPSVSKYNVTGDNGTCLLASMALQLNITYMKKDNTTVTRAFNINPSDKY SGTCGAQLVTLKVGNKSRVLELQFGMNATSSLFFLQGVQLNMTLPDAIEPTFSTSNYSLKALQA SVGNSYKCNSEEHIFVSKALALNVFSVQVQAFRVESDRFGSVEECVQDGNNMLIPIAVGGALAG LVLIVLIAYLIGRKRSHAGYQTI hide sequence

RefSeq Acc Id:	XP_017455483 ⟸ XM_017599994
- Peptide Label:	isoform X1
- UniProtKB:	P97620 (UniProtKB/Swiss-Prot), P14562 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAAPGARRPLLLLLLAGLAHSAPALFEVKDNNGTACIMASFSASFLTTYDAGHVSKVSNMTLPA SAEVLKNSSSCGEKNASEPTLAITFGEGYLLKLTFTKNTTRYSVQHMYFTYNLSDTQFFPNASS KGPDTVDSTTDIKADINKTYRCVSDIRVYMKNVTIVLWDATIQAYLPSSNFSKEETRCPQDQPS PTTGPPSPSPPLVPTNPSVSKYNVTGDNGTCLLASMALQLNITYMKKDNTTVTRAFNINPSDKY SGTCGAQLVTLKVGNKSRVLELQFGMNATSSLFFLQGVQLNMTLPDAIEPTFSTSNYSLKALQA SVGNSYKCNSEEHIFVSKALALNVFSVQVQAFRVESDRFGSVEECVQDGNNMLIPIAVGGALAG LVLIVLIAYLIGRKRSHAGYQTI hide sequence

RefSeq Acc Id:

ENSRNOP00000075799 ⟸ ENSRNOT00000092353

RefSeq Acc Id:

ENSRNOP00000075832 ⟸ ENSRNOT00000092552

RefSeq Acc Id:

ENSRNOP00000026580 ⟸ ENSRNOT00000026580

RefSeq Acc Id:

ENSRNOP00000084480 ⟸ ENSRNOT00000096958

RefSeq Acc Id:

ENSRNOP00000096531 ⟸ ENSRNOT00000105987

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P14562-F1-model_v2	AlphaFold	P14562	1-407	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700232

Promoter ID:

EPDNEW_R10756

Type:

initiation region

Name:

Lamp1_1

Description:

lysosomal-associated membrane protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	81,706,570 - 81,706,630	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2989	AgrOrtholog
BioCyc Gene	G2FUF-10702	BioCyc
Ensembl Genes	ENSRNOG00000019629	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000026580	ENTREZGENE
	ENSRNOP00000026580.5	UniProtKB/TrEMBL
	ENSRNOP00000075832.2	UniProtKB/TrEMBL
	ENSRNOP00000084480	ENTREZGENE
	ENSRNOP00000084480.1	UniProtKB/TrEMBL
	ENSRNOP00000096531.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000026580	ENTREZGENE
	ENSRNOT00000026580.7	UniProtKB/TrEMBL
	ENSRNOT00000092552.2	UniProtKB/TrEMBL
	ENSRNOT00000096958	ENTREZGENE
	ENSRNOT00000096958.1	UniProtKB/TrEMBL
	ENSRNOT00000105987.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.160.110	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	LAMP_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Lysosome-assoc_membr_glycop	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25328	UniProtKB/Swiss-Prot
NCBI Gene	25328	ENTREZGENE
PANTHER	LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11506	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Lamp	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Lamp1	PhenoGen
PRINTS	LYSASSOCTDMP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	LAMP_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LAMP_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LAMP_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC203955
UniProt	A0A0U1RRW1_RAT	UniProtKB/TrEMBL
	A0A6F8P9J1_RAT	UniProtKB/TrEMBL
	A0A8I6A235_RAT	UniProtKB/TrEMBL
	A0A8I6AQY4_RAT	UniProtKB/TrEMBL
	A0A8L2UK78_RAT	UniProtKB/TrEMBL
	LAMP1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	P97620	ENTREZGENE
UniProt Secondary	P97620	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-05-15	Lamp1	lysosomal-associated membrane protein 1	Lamp1	lysosomal membrane glycoprotein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Lamp1	Lysosomal associated membrane protein 1 (120 kDa)			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains 20 potential N-glycosylation sites	729151
gene_expression	expressed in liver, kidney, brain, lung, spleen, heart and pancreas	729151

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)