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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:prochlorperazine
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Accession:CHEBI:8435 term browser browse the term
Definition:A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.
Synonyms:exact_synonym: 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
 related_synonym: 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine;   3-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine;   Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine;   Formula=C20H24ClN3S;   InChI=1S/C20H24ClN3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24/h2-3,5-8,15H,4,9-14H2,1H3;   InChIKey=WIKYUJGCLQQFNW-UHFFFAOYSA-N;   N-(gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine;   Prochlorperazin;   Prochlorpermazine;   Prochlorpromazine;   Procloperazine;   SMILES=CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc23)CC1;   prochlorperazinum;   proclorperazina
 alt_id: CHEBI:59073
 xref: Beilstein:48537;   CAS:58-38-8;   DrugBank:DB00433;   Drug_Central:2274;   HMDB:HMDB0014577;   KEGG:C07403;   KEGG:D00493;   LINCS:LSM-2436
 xref_mesh: MESH:D011346
 xref: PMID:13808146;   PMID:1650428;   PMID:20825390;   PMID:4891872;   Patent:FR1167627;   Patent:GB780193;   Patent:US2902484;   Reaxys:48537;   Wikipedia:Prochlorperazine


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prochlorperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases activity ISO Prochlorperazine results in increased activity of ACHE protein CTD PMID:29614332 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Prochlorperazine binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Tfeb transcription factor EB affects localization ISO Prochlorperazine affects the localization of TFEB protein CTD PMID:28366621 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        pharmacological role 18842
          antagonist 16278
            dopamine receptor D2 antagonist 54
              prochlorperazine 3
                prochlorperazine maleate 0
                prochlorperazine methanesulfonate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        tertiary amino compound 8677
                                          N-alkylpiperazine 3107
                                            N-methylpiperazine 868
                                              prochlorperazine 3
                                                prochlorperazine maleate 0
                                                prochlorperazine methanesulfonate 0
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