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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:prochlorperazine
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Accession:CHEBI:8435 term browser browse the term
Definition:A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.
Synonyms:exact_synonym: 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
 related_synonym: 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine;   3-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine;   Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine;   Formula=C20H24ClN3S;   InChI=1S/C20H24ClN3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24/h2-3,5-8,15H,4,9-14H2,1H3;   InChIKey=WIKYUJGCLQQFNW-UHFFFAOYSA-N;   N-(gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine;   Prochlorperazin;   Prochlorpermazine;   Prochlorpromazine;   Procloperazine;   SMILES=CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc23)CC1;   prochlorperazinum;   proclorperazina
 alt_id: CHEBI:59073
 xref: Beilstein:48537;   CAS:58-38-8;   DrugBank:DB00433;   Drug_Central:2274;   HMDB:HMDB0014577;   KEGG:C07403;   KEGG:D00493;   LINCS:LSM-2436
 xref_mesh: MESH:D011346
 xref: PMID:13808146;   PMID:1650428;   PMID:20825390;   PMID:4891872;   Patent:FR1167627;   Patent:GB780193;   Patent:US2902484;   Reaxys:48537;   Wikipedia:Prochlorperazine


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prochlorperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases activity ISO Prochlorperazine results in increased activity of ACHE protein CTD PMID:29614332 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Prochlorperazine binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Tfeb transcription factor EB affects localization ISO Prochlorperazine affects the localization of TFEB protein CTD PMID:28366621 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        pharmacological role 18793
          antagonist 16194
            dopamine receptor D2 antagonist 52
              prochlorperazine 3
                prochlorperazine maleate 0
                prochlorperazine methanesulfonate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        tertiary amino compound 8629
                                          N-alkylpiperazine 3075
                                            N-methylpiperazine 851
                                              prochlorperazine 3
                                                prochlorperazine maleate 0
                                                prochlorperazine methanesulfonate 0
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