Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-dexrazoxane | multiple interactions | ISO | Rad17 (Mus musculus) | 6480464 | Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of RAD17 mRNA] | CTD | PMID:28973540 | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of RAD17 mRNA] | CTD | PMID:31150632 | 1,2-dimethylhydrazine | decreases expression | ISO | Rad17 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of RAD17 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Rad17 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RAD17 mRNA | CTD | PMID:22206623 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Rad17 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Rad17 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of RAD17 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Rad17 (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of RAD17 mRNA | CTD | PMID:25975270 | 2,3,7,8-Tetrachlorodibenzofuran | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of RAD17 mRNA | CTD | PMID:21346803 | 4,4'-sulfonyldiphenol | increases methylation | ISO | RAD17 (Homo sapiens) | 6480464 | bisphenol S results in increased methylation of RAD17 gene | CTD | PMID:31601247 | 5-aza-2'-deoxycytidine | decreases expression | ISO | RAD17 (Homo sapiens) | 6480464 | Decitabine results in decreased expression of RAD17 mRNA | CTD | PMID:19194470 | acrolein | multiple interactions | ISO | RAD17 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of RAD17 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | all-trans-retinoic acid | multiple interactions | ISO | RAD17 (Homo sapiens) | 6480464 | [Tretinoin co-treated with zoledronic acid] results in increased expression of RAD17 protein | CTD | PMID:20349282 | all-trans-retinoic acid | decreases expression | ISO | RAD17 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of RAD17 mRNA | CTD | PMID:33167477 | alpha-pinene | multiple interactions | ISO | RAD17 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of RAD17 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of and results in increased oxidation of RAD17 mRNA | CTD | PMID:32699268 | arsenous acid | increases expression | ISO | RAD17 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of RAD17 mRNA | CTD | PMID:20458559 | atrazine | increases expression | ISO | RAD17 (Homo sapiens) | 6480464 | Atrazine results in increased expression of RAD17 mRNA | CTD | PMID:22378314 | belinostat | decreases expression | ISO | Rad17 (Mus musculus) | 6480464 | belinostat results in decreased expression of RAD17 mRNA | CTD | PMID:29733868 | benzo[a]pyrene | increases expression | ISO | Rad17 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of RAD17 mRNA | CTD | PMID:20504355 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RAD17 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 and PMID:26238291 | bis(2-chloroethyl) sulfide | increases expression | ISO | Rad17 (Mus musculus) | 6480464 | Mustard Gas results in increased expression of RAD17 mRNA | CTD | PMID:15674844 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of RAD17 mRNA | CTD | PMID:25181051 | bisphenol F | multiple interactions | ISO | RAD17 (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in decreased methylation of RAD17 gene | CTD | PMID:31601247 | chlormequat chloride | increases expression | EXP | | 6480464 | Chlormequat results in increased expression of RAD17 protein | CTD | PMID:34958886 | chromium(6+) | multiple interactions | ISO | RAD17 (Homo sapiens) | 6480464 | RAD17 protein affects the reaction [chromium hexavalent ion promotes the reaction [ATR protein results in increased phosphorylation of SMC1A protein]] and RAD17 protein affects the reaction [chromium hexavalent ion results in increased phosphorylation of SMC1A protein] | CTD | PMID:16876463 | cobalt dichloride | increases expression | ISO | RAD17 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of RAD17 mRNA | CTD | PMID:19376846 | dexamethasone | decreases expression | ISO | RAD17 (Homo sapiens) | 6480464 | Dexamethasone results in decreased expression of RAD17 mRNA | CTD | PMID:12782123 | diarsenic trioxide | increases expression | ISO | RAD17 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of RAD17 mRNA | CTD | PMID:20458559 | dicrotophos | decreases expression | ISO | RAD17 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of RAD17 mRNA | CTD | PMID:28302478 | doxorubicin | multiple interactions | ISO | RAD17 (Homo sapiens) | 6480464 | [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of RAD17 mRNA | CTD | PMID:36634904 | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of RAD17 mRNA | CTD | PMID:29391264 | ethanol | decreases expression | ISO | RAD17 (Homo sapiens) | 6480464 | Ethanol results in decreased expression of RAD17 protein | CTD | PMID:20621659 | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of RAD17 mRNA | CTD | PMID:24136188 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of RAD17 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Rad17 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RAD17 mRNA | CTD | PMID:22206623 | fulvestrant | increases methylation | ISO | RAD17 (Homo sapiens) | 6480464 | Fulvestrant results in increased methylation of RAD17 gene | CTD | PMID:31601247 | fulvestrant | multiple interactions | ISO | RAD17 (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in decreased methylation of RAD17 gene | CTD | PMID:31601247 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of RAD17 mRNA | CTD | PMID:22079235 | idarubicin | multiple interactions | ISO | Rad17 (Mus musculus) | 6480464 | Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of RAD17 mRNA] | CTD | PMID:28973540 | idarubicin | decreases expression | ISO | Rad17 (Mus musculus) | 6480464 | Idarubicin results in decreased expression of RAD17 mRNA | CTD | PMID:28973540 | Lasiocarpine | multiple interactions | ISO | RAD17 (Homo sapiens) | 6480464 | [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RAD17 mRNA | CTD | PMID:33884520 | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of RAD17 mRNA | CTD | PMID:30467583 | Nonidet P-40 | increases expression | ISO | RAD17 (Homo sapiens) | 6480464 | Nonidet P-40 results in increased expression of RAD17 mRNA | CTD | PMID:26552463 | O-methyleugenol | decreases expression | EXP | | 6480464 | methyleugenol results in decreased expression of RAD17 mRNA | CTD | PMID:26011634 | oxybenzone | increases expression | ISO | RAD17 (Homo sapiens) | 6480464 | oxybenzone results in increased expression of RAD17 mRNA | CTD | PMID:36581016 | ozone | multiple interactions | ISO | RAD17 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of RAD17 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | paracetamol | affects expression | ISO | Rad17 (Mus musculus) | 6480464 | Acetaminophen affects the expression of RAD17 mRNA | CTD | PMID:17562736 | pirinixic acid | increases expression | ISO | Rad17 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of RAD17 mRNA | CTD | PMID:18445702 | piroxicam | increases expression | ISO | RAD17 (Homo sapiens) | 6480464 | Piroxicam results in increased expression of RAD17 mRNA | CTD | PMID:21858171 | potassium chromate | decreases expression | ISO | RAD17 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of RAD17 mRNA | CTD | PMID:22714537 | promethazine | decreases expression | EXP | | 6480464 | Promethazine results in decreased expression of RAD17 mRNA | CTD | PMID:26011634 | resveratrol | decreases expression | EXP | | 6480464 | Resveratrol results in decreased expression of RAD17 mRNA | CTD | PMID:33775663 | resveratrol | multiple interactions | ISO | RAD17 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of RAD17 mRNA | CTD | PMID:23557933 | rotenone | increases expression | ISO | RAD17 (Homo sapiens) | 6480464 | Rotenone results in increased expression of RAD17 mRNA | CTD | PMID:18191903 | silicon dioxide | decreases expression | ISO | RAD17 (Homo sapiens) | 6480464 | Silicon Dioxide results in decreased expression of RAD17 mRNA | CTD | PMID:25351596 | sodium arsenite | affects expression | ISO | RAD17 (Homo sapiens) | 6480464 | sodium arsenite affects the expression of RAD17 mRNA | CTD | PMID:29319823 | sunitinib | increases expression | ISO | RAD17 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of RAD17 mRNA | CTD | PMID:31533062 | testosterone | decreases expression | ISO | RAD17 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of RAD17 mRNA | CTD | PMID:33359661 | tetrachloromethane | increases expression | ISO | Rad17 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of RAD17 mRNA | CTD | PMID:27339419 and PMID:31919559 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of RAD17 mRNA] | CTD | PMID:31150632 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of RAD17 mRNA | CTD | PMID:31150632 | thapsigargin | decreases expression | ISO | Rad17 (Mus musculus) | 6480464 | Thapsigargin results in decreased expression of RAD17 protein | CTD | PMID:24648495 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of RAD17 mRNA | CTD | PMID:23411599 more ... | valproic acid | increases expression | ISO | RAD17 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of RAD17 mRNA | CTD | PMID:29154799 | vorinostat | decreases expression | ISO | Rad17 (Mus musculus) | 6480464 | Vorinostat results in decreased expression of RAD17 mRNA | CTD | PMID:32512035 | zoledronic acid | multiple interactions | ISO | RAD17 (Homo sapiens) | 6480464 | [Tretinoin co-treated with zoledronic acid] results in increased expression of RAD17 protein | CTD | PMID:20349282 | |