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ONTOLOGY REPORT - ANNOTATIONS


Term:thioridazine
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Accession:CHEBI:9566 term browser browse the term
Definition:A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.
Synonyms:exact_synonym: 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine
 related_synonym: 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfanyl-phenothiazine;   2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine;   3-Methylmercapto-N-(2'-(N-methyl-2-piperidyl)ethyl)phenothiazine;   Formula=C21H26N2S2;   InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;   InChIKey=KLBQZWRITKRQQV-UHFFFAOYSA-N;   Mallorol;   Malloryl;   Meleril;   Mellaril;   Mellaril-S;   Mellerets;   Mellerette;   Melleril;   Orsanil;   SMILES=CSc1ccc2Sc3ccccc3N(CCC3CCCCN3C)c2c1;   Sonapax;   Thioridazin;   thioridazinum;   tioridazina
 xref: Beilstein:94457;   CAS:50-52-2;   DrugBank:DB00679;   Drug_Central:2637;   HMDB:HMDB0014817;   KEGG:D00373;   LINCS:LSM-1863
 xref_mesh: MESH:D013881
 xref: PMID:10796547;   PMID:11686961;   PMID:1650428;   PMID:17764469;   PMID:17876580;   PMID:19747949;   PMID:20825390;   PMID:26956010;   PMID:27023487;   PMID:27068340;   PMID:9352572;   Reaxys:94457;   Wikipedia:Thioridazine


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thioridazine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 JBrowse link 12 22,665,128 22,676,079 RGD:6480464
G Asah1 N-acylsphingosine amidohydrolase 1 JBrowse link 16 53,998,604 54,030,006 RGD:6480464
G Asns asparagine synthetase (glutamine-hydrolyzing) JBrowse link 4 33,742,876 33,761,106 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Cdc25a cell division cycle 25A JBrowse link 8 117,953,223 117,971,552 RGD:6480464
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:6480464
G Ces1d carboxylesterase 1D JBrowse link 19 15,195,514 15,239,827 RGD:6480464
G Crh corticotropin releasing hormone JBrowse link 2 104,459,999 104,461,863 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Depp1 DEPP1, autophagy regulator JBrowse link 4 148,780,330 148,784,566 RGD:6480464
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:6480464
G Fabp1 fatty acid binding protein 1 JBrowse link 4 99,063,181 99,066,957 RGD:6480464
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 JBrowse link 1 198,199,032 198,209,178 RGD:6480464
G Hpn hepsin JBrowse link 1 89,534,112 89,549,575 RGD:6480464
G Inhbe inhibin subunit beta E JBrowse link 7 70,641,423 70,642,848 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Lss lanosterol synthase JBrowse link 20 12,844,522 12,870,474 RGD:6480464
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 JBrowse link 5 151,776,004 151,779,319 RGD:6480464
G Nupr1 nuclear protein 1, transcriptional regulator JBrowse link 1 194,767,484 194,769,519 RGD:6480464
G Phyh phytanoyl-CoA 2-hydroxylase JBrowse link 17 77,287,580 77,304,482 RGD:6480464
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464
G Serpina3m serine (or cysteine) proteinase inhibitor, clade A, member 3M JBrowse link 6 127,808,785 127,816,067 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc2a3 solute carrier family 2 member 3 JBrowse link 4 155,549,991 155,626,018 RGD:6480464
G Tagln transgelin JBrowse link 8 50,222,895 50,228,369 RGD:6480464
G Wipi1 WD repeat domain, phosphoinositide interacting 1 JBrowse link 10 97,859,730 97,896,949 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19758
    role 19705
      biological role 19704
        pharmacological role 18809
          antagonist 16216
            histamine antagonist 4593
              H1-receptor antagonist 4096
                thioridazine 32
                  thioridazine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19758
    subatomic particle 19756
      composite particle 19756
        hadron 19756
          baryon 19756
            nucleon 19756
              atomic nucleus 19756
                atom 19756
                  main group element atom 19641
                    main group molecular entity 19641
                      s-block molecular entity 19403
                        hydrogen molecular entity 19392
                          hydrides 18362
                            inorganic hydride 17222
                              chalcogen hydride 2376
                                sulfur hydride 1992
                                  hydrogen sulfide 1992
                                    thiol group 1926
                                      thiol 1926
                                        alkanethiol 73
                                          methanethiol 36
                                            methylsulfanyl group 32
                                              thioridazine 32
                                                thioridazine hydrochloride 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.