CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: perphenazine
Accession: CHEBI:8028
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Definition: A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.
Synonyms: exact_synonym: 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol
related_synonym: 2-(4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol; 2-chloro-10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)phenothiazine; 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol; 4-[3-(2-chlorophenothiazin-10-yl)propyl]-1-piperazineethanol; Chlorpiprazine; Formula=C21H26ClN3OS; InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2; InChIKey=RGCVKNLCSQQDEP-UHFFFAOYSA-N; Perfenazine; Perphenazin; SMILES=OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc23)CC1; Trilafon; gamma-(4-(beta-hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine; perfenazina; perphenazinum
xref: Beilstein:54730; CAS:58-39-9; DrugBank:DB00850; Drug_Central:2113; HMDB:HMDB0014988; KEGG:C07427; KEGG:D00503; LINCS:LSM-2224
xref_mesh: MESH:D010546
xref: PMID:14401911; PMID:15674907; PMID:1650428; PMID:26660173; PMID:27150024; Patent:US2766235; Patent:US2860138; Reaxys:54730; Wikipedia:Perphenazine
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Ces1d
carboxylesterase 1D
multiple interactions
ISO
Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]
CTD
PMID:20097249
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO EXP
Perphenazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CTD
PMID:18493746
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Fshb
follicle stimulating hormone subunit beta
decreases expression
EXP
Perphenazine results in decreased expression of FSHB protein
CTD
PMID:6770916
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions decreases activity
ISO
Perphenazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Perphenazine results in decreased activity of KCNH2 protein
CTD
PMID:21158687 PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Lhb
luteinizing hormone subunit beta
decreases expression
EXP
Perphenazine results in decreased expression of LHB protein
CTD
PMID:6770916
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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Prl
prolactin
increases expression
ISO EXP
Perphenazine results in increased expression of PRL protein
CTD
PMID:6770916 PMID:7262630 PMID:17335319
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Perphenazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Tnni3
troponin I3, cardiac type
increases expression
ISO
Perphenazine results in increased expression of TNNI3 protein
CTD
PMID:14742781
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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