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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:perphenazine
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Accession:CHEBI:8028 term browser browse the term
Definition:A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.
Synonyms:exact_synonym: 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol
 related_synonym: 2-(4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol;   2-chloro-10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)phenothiazine;   4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol;   4-[3-(2-chlorophenothiazin-10-yl)propyl]-1-piperazineethanol;   Chlorpiprazine;   Formula=C21H26ClN3OS;   InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2;   InChIKey=RGCVKNLCSQQDEP-UHFFFAOYSA-N;   Perfenazine;   Perphenazin;   SMILES=OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc23)CC1;   Trilafon;   gamma-(4-(beta-hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine;   perfenazina;   perphenazinum
 xref: Beilstein:54730;   CAS:58-39-9;   DrugBank:DB00850;   Drug_Central:2113;   HMDB:HMDB0014988;   KEGG:C07427;   KEGG:D00503;   LINCS:LSM-2224
 xref_mesh: MESH:D010546
 xref: PMID:14401911;   PMID:15674907;   PMID:1650428;   PMID:26660173;   PMID:27150024;   Patent:US2766235;   Patent:US2860138;   Reaxys:54730;   Wikipedia:Perphenazine

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perphenazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D multiple interactions ISO Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate] CTD PMID:20097249 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP		 Perphenazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Perphenazine results in decreased expression of FSHB protein CTD PMID:6770916 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity		 ISO Perphenazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Perphenazine results in decreased activity of KCNH2 protein		 CTD PMID:21158687 PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Perphenazine results in decreased expression of LHB protein CTD PMID:6770916 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Prl prolactin increases expression ISO
EXP		 Perphenazine results in increased expression of PRL protein CTD PMID:6770916 PMID:7262630 PMID:17335319 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Perphenazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Tnni3 troponin I3, cardiac type increases expression ISO Perphenazine results in increased expression of TNNI3 protein CTD PMID:14742781 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      biological role 19757
        inhibitor 18581
          ferroptosis inhibitor 7510
            10H-phenothiazine 31
              perphenazine 8
                perphenazine maleate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    main group molecular entity 19704
                      s-block molecular entity 19489
                        hydrogen molecular entity 19484
                          hydrides 18841
                            inorganic hydride 17688
                              pnictogen hydride 17669
                                nitrogen hydride 17542
                                  azane 17278
                                    ammonia 17277
                                      organic amino compound 17277
                                        tertiary amino compound 8677
                                          N-alkylpiperazine 3106
                                            N-(2-hydroxyethyl)piperazine 87
                                              perphenazine 8
                                                perphenazine maleate 0
paths to the root