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ONTOLOGY REPORT - ANNOTATIONS


Term:perphenazine
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Accession:CHEBI:8028 term browser browse the term
Definition:A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.
Synonyms:exact_synonym: 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol
 related_synonym: 2-(4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol;   2-chloro-10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)phenothiazine;   4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol;   4-[3-(2-chlorophenothiazin-10-yl)propyl]-1-piperazineethanol;   Chlorpiprazine;   Formula=C21H26ClN3OS;   InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2;   InChIKey=RGCVKNLCSQQDEP-UHFFFAOYSA-N;   Perfenazine;   Perphenazin;   SMILES=OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc23)CC1;   Trilafon;   gamma-(4-(beta-hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine;   perfenazina;   perphenazinum
 xref: Beilstein:54730 "Beilstein";   CAS:58-39-9 "ChemIDplus";   CAS:58-39-9 "KEGG COMPOUND";   CAS:58-39-9 "NIST Chemistry WebBook";   DrugBank:DB00850;   Drug_Central:2113 "DrugCentral";   HMDB:HMDB0014988;   KEGG:C07427;   KEGG:D00503;   LINCS:LSM-2224
 xref_mesh: MESH:D010546
 xref: PMID:14401911 "Europe PMC";   PMID:15674907 "Europe PMC";   PMID:1650428 "Europe PMC";   PMID:26660173 "Europe PMC";   PMID:27150024 "Europe PMC";   Patent:US2766235;   Patent:US2860138;   Reaxys:54730 "Reaxys";   Wikipedia:Perphenazine


show annotations for term's descendants       view all columns           Sort by:
 
perphenazine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ces1d carboxylesterase 1D JBrowse link 19 15,195,514 15,239,827 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Fshb follicle stimulating hormone subunit beta JBrowse link 3 98,088,321 98,092,131 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Lhb luteinizing hormone subunit beta JBrowse link 1 101,409,992 101,413,725 RGD:6480464
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Tnni3 troponin I3, cardiac type JBrowse link 1 72,882,806 72,886,490 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            antiemetic 5083
              perphenazine 8
                perphenazine maleate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            inorganic hydride 17104
                              pnictogen hydride 17062
                                nitrogen hydride 16885
                                  azane 16564
                                    ammonia 16561
                                      organic amino compound 16560
                                        tertiary amino compound 8521
                                          N-alkylpiperazine 2953
                                            N-(2-hydroxyethyl)piperazine 80
                                              perphenazine 8
                                                perphenazine maleate 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.