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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mesoridazine
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Accession:CHEBI:6780 term browser browse the term
Definition:A phenothiazine substituted at position 2 (para to the S atom) by a methylsulfinyl group, and on the nitrogen by a 2-(1-methylpiperidin-2-yl)ethyl group.
Synonyms:exact_synonym: 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfinyl)-10H-phenothiazine
 related_synonym: 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylsulfinyl phenothiazine;   2-Methanesulfinyl-10-[2-(1-methyl-piperidin-2-yl)-ethyl]-10H-phenothiazine;   Formula=C21H26N2OS2;   InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;   InChIKey=SLVMESMUVMCQIY-UHFFFAOYSA-N;   SMILES=CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O;   TPS-23;   mesoridazina;   mesoridazinum;   thioridazine thiomethyl sulfoxide;   thioridazine-2-sulfoxide
 alt_id: CHEBI:248004
 xref: CAS:5588-33-0;   DrugBank:DB00933;   Drug_Central:1712;   KEGG:C07143;   KEGG:D02671;   LINCS:LSM-1329
 xref_mesh: MESH:D008653
 xref: Patent:US3084161;   Reaxys:1033986;   Wikipedia:Mesoridazine


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mesoridazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Mesoridazine results in decreased activity of KCNH2 protein CTD PMID:17042915 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        pharmacological role 19030
          antagonist 17213
            dopaminergic antagonist 1631
              mesoridazine 1
                mesoridazine besylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    main group molecular entity 19759
                      s-block molecular entity 19628
                        hydrogen molecular entity 19614
                          hydrides 19087
                            inorganic hydride 18091
                              pnictogen hydride 18080
                                nitrogen hydride 17987
                                  azane 17796
                                    ammonia 17795
                                      organic amino compound 17795
                                        tertiary amino compound 10124
                                          mesoridazine 1
                                            mesoridazine besylate 0
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