Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mesoridazine
go back to main search page
Accession:CHEBI:6780 term browser browse the term
Definition:A phenothiazine substituted at position 2 (para to the S atom) by a methylsulfinyl group, and on the nitrogen by a 2-(1-methylpiperidin-2-yl)ethyl group.
Synonyms:exact_synonym: 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfinyl)-10H-phenothiazine
 related_synonym: 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylsulfinyl phenothiazine;   2-Methanesulfinyl-10-[2-(1-methyl-piperidin-2-yl)-ethyl]-10H-phenothiazine;   Formula=C21H26N2OS2;   InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;   InChIKey=SLVMESMUVMCQIY-UHFFFAOYSA-N;   SMILES=CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O;   TPS-23;   mesoridazina;   mesoridazinum;   thioridazine thiomethyl sulfoxide;   thioridazine-2-sulfoxide
 alt_id: CHEBI:248004
 xref: CAS:5588-33-0;   DrugBank:DB00933;   Drug_Central:1712;   KEGG:C07143;   KEGG:D02671;   LINCS:LSM-1329
 xref_mesh: MESH:D008653
 xref: Patent:US3084161;   Reaxys:1033986;   Wikipedia:Mesoridazine


show annotations for term's descendants           Sort by:
 
mesoridazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Mesoridazine results in decreased activity of KCNH2 protein CTD PMID:17042915 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        pharmacological role 18821
          neurotransmitter agent 16435
            dopaminergic agent 5082
              dopaminergic antagonist 1185
                mesoridazine 1
                  mesoridazine besylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    main group molecular entity 19696
                      s-block molecular entity 19456
                        hydrogen molecular entity 19447
                          hydrides 18703
                            inorganic hydride 17433
                              pnictogen hydride 17405
                                nitrogen hydride 17247
                                  azane 16964
                                    ammonia 16963
                                      organic amino compound 16962
                                        tertiary amino compound 8638
                                          mesoridazine 1
                                            mesoridazine besylate 0
paths to the root