dopaminergic antagonist - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	dopaminergic antagonist	go back to main search page
Accession:	CHEBI:48561	browse the term
Definition:	A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
Synonyms:	related_synonym:	dopamine antagonist; dopamine blocker; dopamine receptor antagonist; dopaminergic antagonists

show annotations for term's descendants Sort by:
Rat (1639) Mouse (1636) Human (1656) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (3) Green Monkey (0) Naked Mole-rat (0) All
Genes (1639)

(+)-butaclamol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

dopamine receptor D2

affects binding

Butaclamol binds to DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

multiple interactions

Butaclamol inhibits the reaction [Dopamine results in increased activity of DRD3 protein]

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

dopamine receptor D4

affects binding

Butaclamol binds to Drd4 protein

RGD

NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Butaclamol results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

(1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

dopamine receptor D2

multiple interactions

5-methoxy-1-methyl-2-(n-propylamino)tetralin binds to and results in decreased activity of DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

multiple interactions

5-methoxy-1-methyl-2-(n-propylamino)tetralin binds to and results in decreased activity of DRD3 protein

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

(Z)-chlorprothixene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

5-hydroxytryptamine receptor 1A

multiple interactions

Chlorprothixene inhibits the reaction [(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to HTR1A protein]

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Chlorprothixene results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

prolactin

increases secretion

Chlorprothixene results in increased secretion of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

amoxapine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases chemical synthesis

CYP3A4 results in increased chemical synthesis of Amoxapine

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

dopamine receptor D1

affects binding

Amoxapine binds to DRD1 protein

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

affects binding

Amoxapine binds to DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

potassium inwardly-rectifying channel, subfamily J, member 3

multiple interactions

Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]

NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124

G

potassium inwardly-rectifying channel, subfamily J, member 5

multiple interactions

Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]

NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518

G

potassium inwardly-rectifying channel, subfamily J, member 6

multiple interactions

Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]

NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758

G

prolactin

increases expression

Amoxapine results in increased expression of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

tachykinin, precursor 1

decreases expression

Amoxapine results in decreased expression of TAC1 protein

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

asenapine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
decreases expression

Asenapine results in decreased activity of CYP1A2 protein
Asenapine results in decreased expression of CYP1A2 mRNA

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

azaperone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Azaperone results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

chlorpromazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases expression

[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCB11 mRNA
Chlorpromazine results in decreased expression of ABCB11 mRNA; Chlorpromazine results in decreased expression of ABCB11 protein

PMID:27344345 PMID:27765674 PMID:28391356 PMID:35708773

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

increases expression
decreases activity

Chlorpromazine analog results in increased expression of ABCB1 mRNA
Chlorpromazine results in decreased activity of ABCB1 protein

PMID:15924885 PMID:16810505

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

affects activity

Chlorpromazine affects the activity of ABCB1B protein

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily B member 4

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCB4 mRNA

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily B member 6

decreases expression

Chlorpromazine results in decreased expression of ABCB6 mRNA

NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924

G

ATP binding cassette subfamily B member 9

increases expression

Chlorpromazine results in increased expression of ABCB9 mRNA

NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931

G

ATP binding cassette subfamily C member 2

increases expression
multiple interactions

Chlorpromazine results in increased expression of ABCC2 mRNA
[Bile Acids and Salts co-treated with Chlorpromazine] results in decreased expression of ABCC2 mRNA

PMID:27765674 PMID:35708773

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

increases expression
multiple interactions
decreases expression

Chlorpromazine analog results in increased expression of ABCC3 mRNA
[Bile Acids and Salts co-treated with Chlorpromazine] results in decreased expression of ABCC3 mRNA
Chlorpromazine results in decreased expression of ABCC3 mRNA

PMID:15924885 PMID:25596134 PMID:35708773

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

increases expression

Chlorpromazine results in increased expression of ABCC4 mRNA

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily G member 2

multiple interactions

Chlorpromazine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ATP binding cassette subfamily G member 8

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCG8 mRNA

NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912

G

acetyl-CoA carboxylase alpha

decreases phosphorylation

Chlorpromazine results in decreased phosphorylation of ACACA protein

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

angiotensin converting enzyme 2

decreases expression

Chlorpromazine results in decreased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acetylcholinesterase

decreases activity
increases activity
multiple interactions

Chlorpromazine results in decreased activity of ACHE protein
Chlorpromazine results in increased activity of ACHE protein
Dichlorvos promotes the reaction [Chlorpromazine results in decreased activity of ACHE protein]

PMID:4859365 PMID:29614332

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

acid phosphatase 5, tartrate resistant

multiple interactions

Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

adrenoceptor alpha 1A

decreases activity

Chlorpromazine results in decreased activity of ADRA1A protein

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

adrenoceptor alpha 1B

decreases activity

Chlorpromazine results in decreased activity of ADRA1B protein

NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919

G

alpha-fetoprotein

decreases expression

Chlorpromazine analog results in decreased expression of AFP mRNA

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

agrin

decreases expression

Chlorpromazine results in decreased expression of AGRN mRNA

NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003

G

aryl hydrocarbon receptor

affects activity

Chlorpromazine affects the activity of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

adenylate kinase 3

decreases expression

Chlorpromazine results in decreased expression of AK3 mRNA

NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625

G

AKT serine/threonine kinase 1

decreases phosphorylation

Chlorpromazine results in decreased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 1 family, member A1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldolase, fructose-bisphosphate A

increases expression

Chlorpromazine results in increased expression of ALDOA mRNA

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

alkaline phosphatase, placental

multiple interactions

Chlorpromazine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Chlorpromazine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]

NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

Chlorpromazine results in decreased expression of AP1S1 mRNA

NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713

G

apolipoprotein C4

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of APOC4 mRNA

NCBI chr 1:79,335,745...79,339,942
Ensembl chr 1:79,335,745...79,339,981

G

apolipoprotein F

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of APOF mRNA

NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946

G

amphiregulin

decreases expression

Chlorpromazine results in decreased expression of AREG mRNA

PMID:15924885 PMID:30703373

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

ARF guanine nucleotide exchange factor 2

increases expression

Chlorpromazine results in increased expression of ARFGEF2 mRNA

NCBI chr 3:155,547,504...155,633,652
Ensembl chr 3:155,547,538...155,630,856

G

Rho guanine nucleotide exchange factor 10

decreases expression

Chlorpromazine results in decreased expression of ARHGEF10 mRNA

NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173

G

N-acylsphingosine amidohydrolase 1

increases expression

Chlorpromazine results in increased expression of ASAH1 mRNA

NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

Chlorpromazine results in increased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

activating transcription factor 4

affects activity
multiple interactions

Chlorpromazine affects the activity of ATF4 protein
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ATF4 mRNA

PMID:25596134 PMID:27344345

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

ATPase H+ transporting V1 subunit B2

decreases expression

Chlorpromazine results in decreased expression of ATP6V1B2 protein

NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745

G

arginine vasopressin

increases expression
multiple interactions

Chlorpromazine results in increased expression of AVP protein
Chlorpromazine inhibits the reaction [Lithium results in increased expression of AVP protein]

PMID:3567260 PMID:3976404

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

BAG cochaperone 4

decreases expression

Chlorpromazine analog results in decreased expression of BAG4 mRNA

NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663

G

Bcl2-like 1

increases expression

Chlorpromazine results in increased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

brain-derived neurotrophic factor

affects response to substance
affects expression

BDNF affects the susceptibility to Chlorpromazine
Chlorpromazine affects the expression of BDNF mRNA

PMID:18408624 PMID:31324950

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

basic helix-loop-helix family, member e40

increases expression

Chlorpromazine analog results in increased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

baculoviral IAP repeat-containing 2

decreases expression

Chlorpromazine results in decreased expression of BIRC2 mRNA

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 5

decreases expression

Chlorpromazine analog results in decreased expression of BIRC5 mRNA; Chlorpromazine results in decreased expression of BIRC5 mRNA

PMID:15924885 PMID:30703373

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

BCL2 interacting protein 3

increases expression

Chlorpromazine results in increased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BTG anti-proliferation factor 2

increases expression

Chlorpromazine analog results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

BTG anti-proliferation factor 3

increases expression

Chlorpromazine analog results in increased expression of BTG3 mRNA

NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170

G

complement C3

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of C3 mRNA

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C6

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of C6 mRNA

NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275

G

calcitonin receptor

multiple interactions

Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]

NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392

G

calreticulin

decreases expression

Chlorpromazine results in decreased expression of CALR mRNA

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

carbonic anhydrase 2

multiple interactions

Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

catalase

multiple interactions
decreases expression
decreases activity

carvedilol inhibits the reaction [Chlorpromazine results in decreased expression of CAT protein]; zolpidem inhibits the reaction [Chlorpromazine results in decreased activity of CAT]

PMID:12010767 PMID:17513028 PMID:25449126

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cellular communication network factor 2

decreases expression

Chlorpromazine results in decreased expression of CCN2 mRNA; Chlorpromazine results in decreased expression of CCN2 protein

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cellular communication network factor 3

affects expression

Chlorpromazine affects the expression of CCN3 mRNA

NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019

G

cyclin B2

decreases expression

Chlorpromazine analog results in decreased expression of CCNB2 mRNA; Chlorpromazine results in decreased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

decreases expression

Chlorpromazine results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D3

decreases expression

Chlorpromazine analog results in decreased expression of CCND3 mRNA

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin F

decreases expression

Chlorpromazine analog results in decreased expression of CCNF mRNA

NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101

G

CD274 molecule

multiple interactions

Chlorpromazine inhibits the reaction [platycodin D results in decreased expression of and results in increased secretion of CD274 protein]

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

G

CD44 molecule

multiple interactions
decreases expression

Chlorpromazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD44 protein]
Chlorpromazine results in decreased expression of CD44 protein

PMID:9929743 PMID:30703373

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

CD86 molecule

increases expression

Chlorpromazine results in increased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cyclin-dependent kinase 5

decreases expression

Chlorpromazine analog results in decreased expression of CDK5 mRNA

NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112

G

cyclin-dependent kinase 7

increases expression

Chlorpromazine analog results in increased expression of CDK7 mRNA

NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

[EGR1 binds to CDKN1A promoter] promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; EGR1 promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2C

decreases expression

Chlorpromazine analog results in decreased expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

carboxylesterase 2H

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of CES2 mRNA

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

complement factor H

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of CFH mRNA

NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838

G

cell growth regulator with EF hand domain 1

decreases expression

Chlorpromazine results in decreased expression of CGREF1 mRNA

NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852

G

chromosome transmission fidelity factor 18

decreases expression

Chlorpromazine analog results in decreased expression of CHTF18 mRNA

NCBI chr10:14,743,006...14,751,044
Ensembl chr10:14,742,621...14,751,050

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

decreases expression

Chlorpromazine results in decreased expression of CITED2 mRNA

NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897

G

CDC28 protein kinase regulatory subunit 2

decreases expression

Chlorpromazine analog results in decreased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

cardiotrophin-like cytokine factor 1

increases expression

Chlorpromazine results in increased expression of CLCF1 mRNA

NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605

G

collagen type XVIII alpha 1 chain

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of COL18A1 mRNA

NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593

G

collagen type I alpha 1 chain

increases expression

Chlorpromazine results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type IV alpha 1 chain

decreases expression

Chlorpromazine results in decreased expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

cortistatin

affects expression

Chlorpromazine affects the expression of CORT mRNA

NCBI chr 5:159,560,591...159,562,032

G

cytochrome c oxidase subunit 8A

affects expression
increases expression

Chlorpromazine affects the expression of COX8A mRNA
Chlorpromazine results in increased expression of COX8A mRNA

NCBI chr 1:204,402,118...204,404,439

G

corticotropin releasing hormone

decreases expression

Chlorpromazine results in decreased expression of CRH mRNA

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

cystathionine gamma-lyase

decreases expression

Chlorpromazine results in decreased expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

cathepsin K

multiple interactions

Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
decreases response to substance
increases expression

[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Chlorpromazine results in decreased activity of CYP1A1 protein
CYP1A1 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in increased expression of CYP1A1 mRNA

PMID:17202759 PMID:18246545 PMID:18493746 PMID:25596134 PMID:26477383 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases response to substance
increases expression
increases oxidation
affects expression
decreases methylation

[Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP1A2 mRNA; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; CYP1A2 protein results in increased metabolism of and results in increased activity of Chlorpromazine
CYP1A2 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in increased expression of CYP1A2 mRNA
CYP1A2 protein results in increased oxidation of Chlorpromazine
Chlorpromazine affects the expression of CYP1A2 mRNA
CYP1A2 protein results in decreased methylation of Chlorpromazine

PMID:18246545 PMID:18493746 PMID:19482014 PMID:20615392 PMID:23397584 More...

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases response to substance
decreases activity
multiple interactions

CYP1B1 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in decreased activity of CYP1B1 protein
[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA]

PMID:26477383 PMID:29724254 PMID:33814510

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
decreases response to substance

[Chlorpromazine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Chlorpromazine inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]]
NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP2B10 mRNA]
CYP2B6 protein results in decreased susceptibility to Chlorpromazine

PMID:10037683 PMID:12049174 PMID:17041008 PMID:26477383

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

decreases expression
decreases response to substance

Chlorpromazine results in decreased expression of CYP2C mRNA; Chlorpromazine results in decreased expression of CYP2C11 mRNA
CYP2C18 protein results in decreased susceptibility to Chlorpromazine

PMID:18246545 PMID:26477383

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
decreases response to substance
decreases activity
affects methylation

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine
CYP2C19 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in decreased activity of CYP2C19 protein
CYP2C19 protein affects the methylation of Chlorpromazine

PMID:15135088 PMID:20615392 PMID:23397584 PMID:26477383

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases response to substance

CYP2C8 protein results in decreased susceptibility to Chlorpromazine

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
decreases response to substance

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; CYP2D6 protein results in increased metabolism of and results in increased activity of Chlorpromazine
CYP2D6 protein results in decreased susceptibility to Chlorpromazine

PMID:19482014 PMID:23397584 PMID:26477383

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity
decreases response to substance

Chlorpromazine results in decreased activity of CYP2E1 protein
CYP2E1 protein results in decreased susceptibility to Chlorpromazine

PMID:15135088 PMID:26477383

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects methylation
affects oxidation
multiple interactions
decreases response to substance
decreases activity

CYP3A4 protein affects the methylation of Chlorpromazine
CYP3A4 protein affects the oxidation of Chlorpromazine
[Chlorpromazine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine
CYP3A4 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in decreased activity of CYP3A4 protein

PMID:15135088 PMID:17041008 PMID:20615392 PMID:23397584 PMID:26477383

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

decreases response to substance

CYP3A5 protein results in decreased susceptibility to Chlorpromazine

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450 family 8 subfamily B member 1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP8B1 mRNA

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

D-amino-acid oxidase

decreases activity

Chlorpromazine results in decreased activity of DAO protein

NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741

G

dendrocyte expressed seven transmembrane protein

multiple interactions

Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]

NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078

G

DNA-damage inducible transcript 3

increases expression

Chlorpromazine results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEPP autophagy regulator 1

increases expression

Chlorpromazine results in increased expression of DEPP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

dopamine receptor D1

decreases activity

Chlorpromazine results in decreased activity of DRD1 protein

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

decreases response to substance
decreases activity

DRD2 polymorphism results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in decreased activity of DRD2 protein

PMID:15694263 PMID:23611293

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dual specificity phosphatase 1

increases expression
affects expression

Chlorpromazine analog results in increased expression of DUSP1 mRNA
Chlorpromazine affects the expression of DUSP1 mRNA

PMID:15924885 PMID:20843724

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 9

decreases expression

Chlorpromazine analog results in decreased expression of DUSP9 mRNA

NCBI chr X:151,351,897...151,355,822
Ensembl chr X:151,351,897...151,355,821

G

E2F transcription factor 1

decreases expression

Chlorpromazine analog results in decreased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

early growth response 1

increases expression
multiple interactions

Chlorpromazine results in increased expression of EGR1
[EGR1 binds to CDKN1A promoter] promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; EGR1 promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; MAPK1 affects the reaction [Chlorpromazine results in increased expression of EGR1]; MAPK3 affects the reaction [Chlorpromazine results in increased expression of EGR1]

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 1

increases expression

Chlorpromazine results in increased expression of EIF1 mRNA

NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
Ensembl chr 5:85,246,764...85,427,327

G

enolase 2

increases expression

Chlorpromazine results in increased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

Chlorpromazine results in increased expression of ERO1A mRNA

NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478

G

coagulation factor II, thrombin

decreases expression

Chlorpromazine analog results in decreased expression of F2 mRNA

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

fatty acid binding protein 1

increases expression

Chlorpromazine results in increased expression of FABP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

Fas cell surface death receptor

increases expression

Chlorpromazine analog results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fructose-bisphosphatase 1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of FBP1 mRNA

NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071

G

F-box protein 22

decreases expression

Chlorpromazine results in decreased expression of FBXO22 mRNA

NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148

G

ferrochelatase

decreases expression

Chlorpromazine results in decreased expression of FECH mRNA

NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348

G

fetuin B

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of FETUB mRNA

NCBI chr11:78,082,158...78,093,022
Ensembl chr11:78,082,156...78,095,135

G

fibrinogen alpha chain

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of FGA mRNA

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fibroblast growth factor 2

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

Fibroblast growth factor receptor 1

decreases expression

Chlorpromazine analog results in decreased expression of FGFR1 mRNA

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

FGR proto-oncogene, Src family tyrosine kinase

decreases expression

Chlorpromazine results in decreased expression of FGR mRNA

NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326

G

FKBP prolyl isomerase 5

multiple interactions

Chlorpromazine inhibits the reaction [Lipopolysaccharides results in decreased expression of FKBP5 protein]

NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674

G

fibronectin type III domain containing 4

increases expression

Chlorpromazine results in increased expression of FNDC4 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675

G

Fos proto-oncogene, AP-1 transcription factor subunit

affects expression

Chlorpromazine affects the expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

affects expression

Chlorpromazine affects the expression of FOSB mRNA

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

FOS like 1, AP-1 transcription factor subunit

increases expression
affects expression

Chlorpromazine analog results in increased expression of FOSL1 mRNA
Chlorpromazine affects the expression of FOSL1 mRNA

PMID:15924885 PMID:20843724

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

FOS like 2, AP-1 transcription factor subunit

affects expression

Chlorpromazine affects the expression of FOSL2 mRNA

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

G

ferritin heavy chain 1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of FTH1 mRNA

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

glucose-6-phosphate dehydrogenase

decreases expression
decreases activity
multiple interactions

Chlorpromazine analog results in decreased expression of G6PD mRNA
Chlorpromazine results in decreased activity of G6PD protein
[Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; Taurine inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]

PMID:15924885 PMID:33548410

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

glutamate decarboxylase 1

decreases methylation
multiple interactions

Chlorpromazine results in decreased methylation of GAD1 promoter
Valproic Acid promotes the reaction [Chlorpromazine results in decreased methylation of GAD1 promoter]

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

glucagon receptor

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of GCGR mRNA

NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640

G

glutamate-cysteine ligase, catalytic subunit

decreases expression

Chlorpromazine results in decreased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

growth differentiation factor 15

increases expression

Chlorpromazine results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glycerophosphodiester phosphodiesterase domain containing 3

increases expression

Chlorpromazine results in increased expression of GDPD3 mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063

G

glial fibrillary acidic protein

affects expression

Chlorpromazine affects the expression of GFAP mRNA

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

glycoprotein nmb

increases expression

Chlorpromazine results in increased expression of GPNMB mRNA

NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367

G

glutamic--pyruvic transaminase

increases expression

Chlorpromazine results in increased expression of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione-disulfide reductase

decreases activity

Chlorpromazine results in decreased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of GSTA1 mRNA

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

hypoxia inducible factor 1 subunit alpha

affects activity

Chlorpromazine affects the activity of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression

Chlorpromazine results in increased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

Chlorpromazine results in increased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

heme oxygenase 1

increases expression
affects expression

Chlorpromazine results in increased expression of HMOX1 mRNA
Chlorpromazine affects the expression of HMOX1 mRNA

PMID:15924885 PMID:25596134 PMID:31324950

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hepsin

increases expression

Chlorpromazine results in increased expression of HPN mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811

G

heat shock protein family A (Hsp70) member 2

increases expression
decreases expression

Chlorpromazine results in increased expression of HSPA2 mRNA
Chlorpromazine results in decreased expression of HSPA2 mRNA; Chlorpromazine results in decreased expression of HSPA2 protein

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family B (small) member 1

increases expression
decreases expression

Chlorpromazine results in increased expression of HSPB1 mRNA
Chlorpromazine results in decreased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family D (Hsp60) member 1

increases expression

Chlorpromazine results in increased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family E (Hsp10) member 1

increases expression

Chlorpromazine results in increased expression of HSPE1 mRNA

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

integrin-binding sialoprotein

decreases expression
multiple interactions

Chlorpromazine results in decreased expression of IBSP mRNA
herbimycin inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA]; U 0126 inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA]

NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693

G

interferon beta 1

multiple interactions

Chlorpromazine promotes the reaction [PAM2-CSK4 results in increased expression of IFNB1 mRNA]

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

interferon gamma

multiple interactions

[Chlorpromazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon, lambda receptor 1

increases expression

Chlorpromazine results in increased expression of IFNLR1 mRNA

NCBI chr 5:147,919,547...147,942,328
Ensembl chr 5:147,919,908...147,942,332

G

insulin-like growth factor binding protein 1

increases expression

Chlorpromazine results in increased expression of IGFBP1 mRNA

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

increases expression

Chlorpromazine analog results in increased expression of IKBKG mRNA

NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499

G

interleukin 1 alpha

multiple interactions

[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

decreases expression

Chlorpromazine results in decreased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

multiple interactions

[Chlorpromazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]; Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]

PMID:11014349 PMID:29594315

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 6

multiple interactions

[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibin subunit beta E

increases expression

Chlorpromazine results in increased expression of INHBE mRNA

PMID:15342952 PMID:17175557

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

insulin 1

decreases secretion

Chlorpromazine results in decreased secretion of INS1 protein

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin induced gene 2

decreases expression

Chlorpromazine results in decreased expression of INSIG2 mRNA

NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923

G

insulin receptor substrate 2

multiple interactions

Chlorpromazine results in decreased expression of and results in decreased phosphorylation of IRS2 protein; Chlorpromazine results in decreased expression of and results in increased degradation of IRS2 protein

PMID:17512020 PMID:18308779

NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

Chlorpromazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Chlorpromazine results in decreased activity of KCNH2 protein

PMID:15071359 PMID:21158687 PMID:24052561

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium calcium-activated channel subfamily N member 2

decreases activity

Chlorpromazine results in decreased activity of KCNN2 protein

NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347

G

KLF transcription factor 4

multiple interactions
decreases expression

[Chlorpromazine co-treated with Cholic Acids] affects the expression of KLF4 mRNA
Chlorpromazine results in decreased expression of KLF4 mRNA

PMID:27344345 PMID:30703373

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

kallikrein B1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of KLKB1 mRNA

NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053

G

kininogen 1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of KNG1 mRNA

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

large tumor suppressor kinase 1

increases phosphorylation

Chlorpromazine results in increased phosphorylation of LATS1 protein

NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640

G

lactate dehydrogenase C

decreases activity
multiple interactions

Chlorpromazine results in decreased activity of LDHC protein
[Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; Taurine inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]

NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378

G

low density lipoprotein receptor

increases expression

Chlorpromazine results in increased expression of LDLR mRNA

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

leptin

increases expression

Chlorpromazine results in increased expression of LEP protein

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

lanosterol synthase

increases expression

Chlorpromazine results in increased expression of LSS mRNA

PMID:15342952 PMID:17175557

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

microtubule-associated protein 2

increases expression

Chlorpromazine results in increased expression of MAP2 mRNA

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase 1

multiple interactions

Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]
MAPK1 affects the reaction [Chlorpromazine results in increased expression of EGR1]

PMID:11014349 PMID:20368687

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

decreases expression

Chlorpromazine analog results in decreased expression of MAPK14 mRNA

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

decreases expression
multiple interactions

Chlorpromazine analog results in decreased expression of MAPK3 mRNA
MAPK3 affects the reaction [Chlorpromazine results in increased expression of EGR1]
Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]

PMID:11014349 PMID:15924885 PMID:20368687

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein; Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

MAPK activated protein kinase 2

increases expression

Chlorpromazine results in increased expression of MAPKAPK2 mRNA

NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457

G

minichromosome maintenance complex component 3

decreases expression

Chlorpromazine analog results in decreased expression of MCM3 mRNA

NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314

G

minichromosome maintenance complex component 5

decreases expression

Chlorpromazine analog results in decreased expression of MCM5 mRNA

NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389

G

MDM2 proto-oncogene

increases expression

Chlorpromazine results in increased expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

melanocyte inducing transcription factor

increases expression

Chlorpromazine results in increased expression of MITF protein

NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145

G

marker of proliferation Ki-67

decreases expression

Chlorpromazine analog results in decreased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 9

multiple interactions

Chlorpromazine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]; Chlorpromazine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

musculin

decreases expression

Chlorpromazine results in decreased expression of MSC mRNA

NCBI chr 5:4,547,335...4,553,206
Ensembl chr 5:4,547,405...4,553,203

G

mutS homolog 2

decreases expression

Chlorpromazine results in decreased expression of MSH2 mRNA

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

macrophage stimulating 1

increases phosphorylation

Chlorpromazine results in increased phosphorylation of MST1 protein

NCBI chr 8:108,767,886...108,773,425
Ensembl chr 8:108,768,839...108,773,416

G

metallothionein 1

increases expression

Chlorpromazine results in increased expression of MT1A mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

MYB proto-oncogene like 2

decreases expression

Chlorpromazine analog results in decreased expression of MYBL2 mRNA

NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

Chlorpromazine results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

nicotinamide phosphoribosyltransferase

increases expression

Chlorpromazine results in increased expression of NAMPT mRNA

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

Nanog homeobox

decreases expression

Chlorpromazine results in decreased expression of NANOG mRNA

NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116

G

NADH:ubiquinone oxidoreductase core subunit S3

decreases expression

Chlorpromazine results in decreased expression of NDUFS3 protein

NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824

G

nectin cell adhesion molecule 2

multiple interactions

Chlorpromazine inhibits the reaction [Cadmium Chloride results in decreased expression of and affects the localization of NECTIN2 protein]

NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360

G

neural precursor cell expressed, developmentally down-regulated 9

decreases expression

Chlorpromazine results in decreased expression of NEDD9 mRNA

NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019

G

neurofilament heavy chain

affects expression

Chlorpromazine affects the expression of NEFH mRNA

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

nuclear factor of activated T-cells 1

multiple interactions

Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

NFE2 like bZIP transcription factor 2

decreases expression
affects activity

Chlorpromazine results in decreased expression of NFE2L2 mRNA
Chlorpromazine affects the activity of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

ninjurin 1

increases expression

Chlorpromazine results in increased expression of NINJ1 mRNA

NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704

G

natriuretic peptide B

increases expression

Chlorpromazine results in increased expression of NPPB protein

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

nuclear receptor subfamily 0, group B, member 2

increases expression

Chlorpromazine results in increased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group H, member 4

decreases expression

Chlorpromazine results in decreased expression of NR1H4 mRNA

PMID:27765674 PMID:28391356

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

nuclear receptor subfamily 1, group I, member 2

increases expression
multiple interactions

Chlorpromazine analog results in increased expression of NR1I2 mRNA
[Chlorpromazine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

PMID:15924885 PMID:17041008

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

increases activity
increases expression
multiple interactions

Chlorpromazine results in increased activity of NR1I3 protein
Chlorpromazine results in increased expression of NR1I3 mRNA
[Chlorpromazine co-treated with Cholic Acids] affects the expression of NR1I3 mRNA; [Chlorpromazine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Chlorpromazine inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]]
NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP2B10 mRNA]; NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP3A11 mRNA]

PMID:10037683 PMID:12049174 PMID:12948398 PMID:17041008 PMID:22310298 More...

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

Chlorpromazine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear protein 1, transcriptional regulator

increases expression

Chlorpromazine results in increased expression of NUPR1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

origin recognition complex, subunit 1

decreases expression

Chlorpromazine analog results in decreased expression of ORC1 mRNA

NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375

G

orosomucoid 1

affects binding
multiple interactions

Chlorpromazine binds to ORM1 protein alternative form
Chlorpromazine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

protein disulfide isomerase family A, member 2

increases expression

Chlorpromazine analog results in increased expression of PDIA2 mRNA

NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931

G

protein disulfide isomerase family A, member 5

decreases expression

Chlorpromazine results in decreased expression of PDIA5 mRNA

NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084

G

pyruvate dehydrogenase kinase 1

increases expression

Chlorpromazine results in increased expression of PDK1 mRNA

NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038

G

pyruvate dehydrogenase kinase 4

increases expression

Chlorpromazine results in increased expression of PDK4 mRNA

NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850

G

phytanoyl-CoA 2-hydroxylase

increases expression

Chlorpromazine results in increased expression of PHYH mRNA

NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409

G

protein inhibitor of activated STAT, 1

increases expression

Chlorpromazine results in increased expression of PIAS1 mRNA

NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905

G

Pim-1 proto-oncogene, serine/threonine kinase

increases expression

Chlorpromazine analog results in increased expression of PIM1 mRNA

NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174

G

pirin

decreases expression

Chlorpromazine results in decreased expression of PIR mRNA

NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218

G

perilipin 2

increases expression

Chlorpromazine results in increased expression of PLIN2 mRNA

NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319

G

prostate transmembrane protein, androgen induced 1

decreases expression

Chlorpromazine results in decreased expression of PMEPA1 mRNA

NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454

G

DNA polymerase alpha 1, catalytic subunit

decreases expression

Chlorpromazine analog results in decreased expression of POLA1 mRNA

NCBI chr X:58,034,617...58,348,612
Ensembl chr X:58,034,619...58,348,536

G

DNA polymerase delta 4, accessory subunit

increases expression

Chlorpromazine analog results in increased expression of POLD4 mRNA

NCBI chr 1:201,526,591...201,528,406
Ensembl chr 1:201,526,665...201,528,401

G

POU class 5 homeobox 1

decreases expression

Chlorpromazine results in decreased expression of POU5F1 mRNA

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator-activated receptor gamma

affects activity

Chlorpromazine affects the activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 1, regulatory subunit 15A

increases expression

Chlorpromazine results in increased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

protein kinase AMP-activated catalytic subunit alpha 1

decreases phosphorylation

Chlorpromazine results in decreased phosphorylation of PRKAA1 protein

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

prolactin

increases expression

Chlorpromazine results in increased expression of PRL protein

PMID:718334 PMID:996201

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

retinoic acid receptor, alpha

decreases expression

Chlorpromazine results in decreased expression of RARA mRNA

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

Rho family GTPase 1

decreases expression

Chlorpromazine results in decreased expression of RND1 mRNA

NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399

G

Rho family GTPase 3

decreases expression

Chlorpromazine results in decreased expression of RND3 mRNA

NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327

G

ring finger protein 121

decreases expression

Chlorpromazine results in decreased expression of RNF121 mRNA

NCBI chr 1:156,377,368...156,439,936
Ensembl chr 1:156,377,364...156,446,826

G

RUNX family transcription factor 1

increases expression

Chlorpromazine results in increased expression of RUNX1 mRNA

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

retinoid X receptor gamma

affects response to substance

RXRG protein affects the susceptibility to Chlorpromazine

NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167

G

spermidine/spermine N1-acetyl transferase 1

increases expression

Chlorpromazine results in increased expression of SAT1 mRNA

NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813

G

sterol-C5-desaturase

increases expression

Chlorpromazine results in increased expression of SC5D mRNA

NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273

G

serpin family A member 3N

increases expression

Chlorpromazine results in increased expression of SERPINA3 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

serpin family H member 1

increases expression

Chlorpromazine results in increased expression of SERPINH1 mRNA

NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801

G

sestrin 1

decreases expression

Chlorpromazine results in decreased expression of SESN1 mRNA

NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697

G

salt-inducible kinase 1

decreases expression

Chlorpromazine results in decreased expression of SIK1 mRNA

NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991

G

solute carrier family 10 member 1

decreases expression
increases expression

Chlorpromazine results in decreased expression of SLC10A1 mRNA
Chlorpromazine results in increased expression of SLC10A1 mRNA

PMID:27765674 PMID:28391356 PMID:35708773

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 12, member 8

increases expression

Chlorpromazine results in increased expression of SLC12A8 mRNA

NCBI chr11:67,116,876...67,266,548
Ensembl chr11:67,116,877...67,266,834

G

solute carrier family 19 member 1

multiple interactions
decreases activity

Chlorpromazine inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]
Chlorpromazine results in decreased activity of SLC19A1 protein

NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972

G

solute carrier family 1 member 5

increases expression

Chlorpromazine results in increased expression of SLC1A5 mRNA

NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 22 member 2

multiple interactions

Chlorpromazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 7

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of SLC22A7 mRNA

NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921

G

solute carrier family 2 member 3

decreases expression

Chlorpromazine results in decreased expression of SLC2A3 mRNA

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

G

solute carrier family 31 member 1

multiple interactions

Chlorpromazine inhibits the reaction [Copper affects the localization of SLC31A1 protein]

NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228

G

solute carrier family 3 member 2

increases expression

Chlorpromazine results in increased expression of SLC3A2 mRNA

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

SLC51 subunit beta

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of SLC51B mRNA

NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145

G

solute carrier family 6 member 6

increases expression

Chlorpromazine results in increased expression of SLC6A6 mRNA

NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875

G

solute carrier organic anion transporter family, member 2b1

decreases expression

Chlorpromazine results in decreased expression of SLCO2B1 mRNA

NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353

G

superoxide dismutase 1

multiple interactions

Chlorpromazine inhibits the reaction [Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

SRY-box transcription factor 2

decreases expression

Chlorpromazine results in decreased expression of SOX2 mRNA

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

secreted phosphoprotein 1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

splA/ryanodine receptor domain and SOCS box containing 1

increases expression

Chlorpromazine results in increased expression of SPSB1 mRNA

NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

Chlorpromazine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased phosphorylation of SRC protein]

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

sterol regulatory element binding transcription factor 2

multiple interactions

Chlorpromazine results in increased cleavage of and results in increased activity of SREBF2 protein

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

spermatid perinuclear RNA binding protein

increases expression

Chlorpromazine results in increased expression of STRBP mRNA

NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949

G

steroid sulfatase

multiple interactions

Chlorpromazine inhibits the reaction [Tretinoin results in increased activity of STS protein]

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

transgelin

decreases expression

Chlorpromazine results in decreased expression of TAGLN mRNA

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

transferrin

affects localization

Chlorpromazine affects the localization of TF protein

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transcription factor Dp-1

decreases expression

Chlorpromazine analog results in decreased expression of TFDP1 mRNA

NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817

G

TCDD-inducible poly(ADP-ribose) polymerase

increases expression

Chlorpromazine results in increased expression of TIPARP mRNA

NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327

G

TIR domain containing adaptor protein

multiple interactions

TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipoteichoic acid]

NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432

G

tumor necrosis factor

decreases expression
increases response to substance
multiple interactions

Chlorpromazine analog results in decreased expression of TNF protein; Chlorpromazine results in decreased expression of TNF mRNA
TNF protein results in increased susceptibility to Chlorpromazine
[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein; [Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein; Chlorpromazine inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride]; Chlorpromazine inhibits the reaction [hydroquinone results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased susceptibility to Chlorpromazine]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein]
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine; Chlorpromazine results in decreased expression of and results in decreased activity of TNF protein

PMID:8550079 PMID:15052360 PMID:19362101 PMID:20371967 PMID:22414385 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 8

increases expression

Chlorpromazine results in increased expression of TNFAIP8 mRNA

NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517

G

TNF receptor superfamily member 14

increases expression

Chlorpromazine analog results in increased expression of TNFRSF14 mRNA

NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703

G

TNF superfamily member 11

decreases activity
multiple interactions

Chlorpromazine results in decreased activity of TNFSF11; Chlorpromazine results in decreased activity of TNFSF11 protein
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

tumor protein p53

affects activity

Chlorpromazine affects the activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TRAF type zinc finger domain containing 1

decreases expression

Chlorpromazine results in decreased expression of TRAFD1 mRNA

NCBI chr12:35,165,606...35,179,525
Ensembl chr12:35,165,606...35,179,525

G

tubulin, alpha 1A

decreases expression

Chlorpromazine results in decreased expression of TUBA1A mRNA

NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186

G

thioredoxin 1

decreases expression

Chlorpromazine results in decreased expression of TXN1 mRNA

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin reductase 1

multiple interactions

[Chlorpromazine co-treated with Cholic Acids] affects the expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

tyrosinase

increases expression

Chlorpromazine results in increased expression of TYR protein

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

G

uracil-DNA glycosylase

decreases expression

Chlorpromazine analog results in decreased expression of UNG mRNA

NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206

G

unk like zinc finger

decreases expression

Chlorpromazine results in decreased expression of UNKL mRNA

NCBI chr10:14,206,125...14,252,226
Ensembl chr10:14,206,189...14,252,225

G

vascular endothelial growth factor A

increases expression

Chlorpromazine analog results in increased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor B

increases expression

Chlorpromazine results in increased expression of VEGFB mRNA

NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944

G

tryptophanyl-tRNA synthetase 1

increases expression

Chlorpromazine results in increased expression of WARS1 mRNA

NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269

G

WD repeat domain, phosphoinositide interacting 1

increases expression

Chlorpromazine results in increased expression of WIPI1 mRNA

PMID:15342952 PMID:17175557

NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846

G

X-box binding protein 1

affects activity
decreases expression

Chlorpromazine affects the activity of XBP1 protein
Chlorpromazine results in decreased expression of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

G

XPC complex subunit, DNA damage recognition and repair factor

decreases expression

Chlorpromazine results in decreased expression of XPC mRNA

NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010

G

X-ray repair cross complementing 4

decreases expression

Chlorpromazine results in decreased expression of XRCC4 mRNA

NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808

G

Yes1 associated transcriptional regulator

multiple interactions

Chlorpromazine results in decreased expression of and results in increased phosphorylation of and affects the localization of YAP1 protein

NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010

clopenthixol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Clopenthixol results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

clozapine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl-tRNA synthetase 1

increases expression

Clozapine results in increased expression of AARS1 protein

NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147

G

ATP binding cassette subfamily B member 11

decreases activity

Clozapine results in decreased activity of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases activity

Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein]
Clozapine results in decreased activity of ABCB1 protein

PMID:9111066 PMID:16810505

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

multiple interactions

Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter]

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily E member 1

increases expression

Clozapine results in increased expression of ABCE1 protein

NCBI chr19:28,205,566...28,230,489
Ensembl chr19:28,205,555...28,230,489

G

ATP binding cassette subfamily G member 1

increases expression

Clozapine results in increased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

ATP binding cassette subfamily G member 2

multiple interactions

Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

actin binding LIM protein family, member 2

increases expression

Clozapine results in increased expression of ABLIM2 mRNA

NCBI chr14:74,865,409...74,990,334
Ensembl chr14:74,866,281...74,990,334

G

acetyl-CoA acetyltransferase 2

increases expression

Clozapine results in increased expression of ACAT2 mRNA

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

acyl-CoA thioesterase 2

increases expression

Clozapine results in increased expression of ACOT2 protein

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

G

acyl-CoA thioesterase 7

decreases expression

Clozapine results in decreased expression of ACOT7 protein

NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309

G

acyl-CoA oxidase 1

multiple interactions

[Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

actin, beta

decreases expression

Clozapine results in decreased expression of ACTB protein

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actin, beta-like 2

increases expression

Clozapine results in increased expression of ACTBL2 protein

NCBI chr 2:42,858,020...42,860,767
Ensembl chr 2:42,858,020...42,860,767

G

actin related protein 3

decreases expression

Clozapine results in decreased expression of ACTR3 protein

NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124

G

actin related protein 5

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of ACTR5 protein

NCBI chr 3:147,282,461...147,295,870
Ensembl chr 3:147,282,624...147,296,110

G

ADAM metallopeptidase domain 1a

decreases expression

Clozapine results in decreased expression of ADAM1A mRNA

NCBI chr12:35,017,433...35,020,300
Ensembl chr12:35,017,315...35,020,311

G

ADAM metallopeptidase with thrombospondin type 1 motif, 12

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of ADAMTS12 protein

NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629

G

adenylate cyclase 5

affects response to substance
multiple interactions

ADCY5 protein affects the susceptibility to Clozapine
SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine]

NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974

G

alcohol dehydrogenase 5 (class III), chi polypeptide

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of ADH5 protein

NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591

G

adiponectin, C1Q and collagen domain containing

decreases expression
increases expression
multiple interactions

Clozapine results in decreased expression of ADIPOQ protein
Clozapine results in increased expression of ADIPOQ protein
Clozapine results in increased expression of ADIPOQ mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]

PMID:17933447 PMID:18162013 PMID:20564506

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adenosine A2a receptor

decreases expression

Clozapine results in decreased expression of ADORA2A mRNA

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adrenoceptor alpha 1A

multiple interactions

Clozapine binds to and results in decreased activity of ADRA1A protein

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

1-acylglycerol-3-phosphate O-acyltransferase 1

decreases expression

Clozapine results in decreased expression of AGPAT1 mRNA

NCBI chr20:4,135,955...4,144,880
Ensembl chr20:4,135,957...4,145,278

G

angiotensinogen

multiple interactions

Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

increases expression

Clozapine results in increased expression of AIMP1 protein

NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728

G

adenylate kinase 1

decreases expression

Clozapine results in decreased expression of AK1 protein

NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041

G

AKT serine/threonine kinase 1

increases expression
decreases expression
increases phosphorylation

Clozapine results in increased expression of AKT1 mRNA; Clozapine results in increased expression of AKT1 protein
Clozapine results in decreased expression of AKT1 mRNA
Clozapine results in increased phosphorylation of AKT1 protein

PMID:15860345 PMID:19440698

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

increases expression

Clozapine results in increased expression of AKT2 mRNA

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

albumin

multiple interactions
affects binding

Clozapine results in decreased expression of and results in decreased reduction of ALB protein
Clozapine binds to ALB protein
[[[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine] which affects the activity of ALB protein; [[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine; [stearic acid binds to ALB protein] which affects the susceptibility to Clozapine; stearic acid inhibits the reaction [Clozapine binds to ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

increases expression

Clozapine results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldolase, fructose-bisphosphate A

increases expression

Clozapine results in increased expression of ALDOA mRNA

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

aldolase, fructose-bisphosphate B

increases expression
decreases expression

Clozapine results in increased expression of ALDOB protein
Clozapine results in decreased expression of ALDOB protein

PMID:34122009 PMID:36482696

NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116

G

aldolase, fructose-bisphosphate C

decreases expression
increases expression

Clozapine results in decreased expression of ALDOC mRNA
Clozapine results in increased expression of ALDOC mRNA

PMID:15860345 PMID:16465460

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

alkaline phosphatase, placental

multiple interactions

Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]

NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606

G

Aly/REF export factor

decreases expression

Clozapine results in decreased expression of ALYREF protein

NCBI chr10:105,871,424...105,875,076
Ensembl chr10:105,871,306...105,875,069

G

annexin A1

decreases expression

Clozapine results in decreased expression of ANXA1 protein

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A5

decreases expression

Clozapine results in decreased expression of ANXA5 protein

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

annexin A6

decreases expression

Clozapine results in decreased expression of ANXA6 protein

NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

Clozapine results in decreased expression of AP1S1 mRNA

NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713

G

adaptor related protein complex 2 subunit beta 1

increases expression

Clozapine results in increased expression of AP2B1 mRNA

NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013

G

adaptor related protein complex 3 subunit beta 1

increases expression

Clozapine results in increased expression of AP3B1 protein

NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935

G

apolipoprotein A5

affects response to substance

APOA5 gene polymorphism affects the susceptibility to Clozapine

NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816

G

apolipoprotein D

increases expression

Clozapine results in increased expression of APOD mRNA; Clozapine results in increased expression of APOD protein

PMID:11158250 PMID:14647396 PMID:17266109

NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305

G

amyloid beta precursor protein

increases expression

Clozapine results in increased expression of APP protein

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

activity-regulated cytoskeleton-associated protein

decreases expression

Clozapine results in decreased expression of ARC mRNA

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

Cdc42 guanine nucleotide exchange factor 9

decreases expression

Clozapine results in decreased expression of ARHGEF9 mRNA

NCBI chr X:59,919,560...60,077,538
Ensembl chr X:59,920,870...60,077,513

G

ARF like GTPase 8A

decreases expression

Clozapine results in decreased expression of ARL8A protein

NCBI chr13:46,585,845...46,594,851
Ensembl chr13:46,585,845...46,594,851

G

acidic residue methyltransferase 1

increases expression

Clozapine results in increased expression of ARMT1 protein

NCBI chr 1:40,894,558...40,918,302
Ensembl chr 1:40,894,550...40,918,302

G

actin related protein 2/3 complex, subunit 4

affects expression

Clozapine affects the expression of ARPC4 mRNA

NCBI chr 4:146,522,255...146,532,784
Ensembl chr 4:146,522,176...146,532,785

G

N-acylsphingosine amidohydrolase 1

increases expression

Clozapine results in increased expression of ASAH1 mRNA

PMID:15342952 PMID:17175557

NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

Clozapine results in increased expression of ASNS mRNA; Clozapine results in increased expression of ASNS protein

PMID:15342952 PMID:17175557 PMID:36482696

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

aspartate-beta-hydroxylase

increases expression

Clozapine results in increased expression of ASPH protein

NCBI chr 5:22,601,581...22,814,107
Ensembl chr 5:22,603,486...22,813,876

G

argininosuccinate synthase 1

increases expression

Clozapine results in increased expression of ASS1 protein

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

ATPase family, AAA domain containing 3A

decreases expression

Clozapine results in decreased expression of ATAD3A protein

NCBI chr 5:166,350,302...166,370,492
Ensembl chr 5:166,350,304...166,370,482

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

increases expression

Clozapine results in increased expression of ATP2A3 protein

NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748

G

ATP synthase F1 subunit beta

decreases expression

Clozapine results in decreased expression of ATP5F1B protein

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase peripheral stalk-membrane subunit b

increases expression

Clozapine results in increased expression of ATP5PB protein

NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418

G

ATPase H+ transporting V1 subunit A

decreases expression

Clozapine results in decreased expression of ATP6V1A protein

NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694

G

ATPase H+ transporting V1 subunit B1

decreases expression

Clozapine results in decreased expression of ATP6V1B1 protein

NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475

G

ATPase H+ transporting V1 subunit B2

decreases expression

Clozapine results in decreased expression of ATP6V1B2 protein

PMID:19441803 PMID:34122009

NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745

G

ataxin 10

increases expression

Clozapine results in increased expression of ATXN10 protein

NCBI chr 7:116,441,768...116,565,093
Ensembl chr 7:116,441,613...116,565,087

G

axin 2

decreases expression

Clozapine results in decreased expression of AXIN2 mRNA

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

beta-secretase 2

increases expression

Clozapine results in increased expression of BACE2 protein

NCBI chr11:36,707,447...36,789,550
Ensembl chr11:36,707,458...36,789,546

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions
decreases expression

Clozapine results in increased expression of BAX mRNA; Clozapine results in increased expression of BAX protein
CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]
Clozapine results in decreased expression of BAX protein

PMID:16160616 PMID:17069804

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

bromodomain adjacent to zinc finger domain, 1B

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of BAZ1B protein

NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426

G

BCAR1 scaffold protein, Cas family member

decreases expression

Clozapine results in decreased expression of BCAR1 protein

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

G

BCL2, apoptosis regulator

increases expression

Clozapine results in increased expression of BCL2 mRNA; Clozapine results in increased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 14

decreases expression

Clozapine results in decreased expression of BCL2L14 protein

NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086

G

brain-derived neurotrophic factor

decreases expression
increases expression

Clozapine results in decreased expression of BDNF mRNA
Clozapine results in increased expression of BDNF mRNA; Clozapine results in increased expression of BDNF protein

PMID:11488957 PMID:12478621 PMID:17442489

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

Bet1 golgi vesicular membrane trafficking protein-like

decreases expression

Clozapine results in decreased expression of BET1L mRNA

NCBI chr 1:195,931,407...195,935,072
Ensembl chr 1:195,931,411...195,935,040

G

BCL2-interacting killer

multiple interactions
increases expression

CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]

NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296

G

bromodomain PHD finger transcription factor

decreases expression

Clozapine results in decreased expression of BPTF mRNA

NCBI chr10:91,980,279...92,082,731
Ensembl chr10:91,982,758...92,082,769

G

basic leucine zipper and W2 domains 1

increases expression

Clozapine results in increased expression of BZW1 protein

NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430

G

calcium voltage-gated channel subunit alpha1 A

decreases expression

Clozapine results in decreased expression of CACNA1A mRNA

PMID:14647396 PMID:16715494

NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225

G

calcium binding and coiled coil domain 1

increases expression

Clozapine results in increased expression of CALCOCO1 protein

NCBI chr 7:133,834,705...133,849,515
Ensembl chr 7:133,834,707...133,849,422

G

calmodulin 2

increases expression

Clozapine results in increased expression of CALM2 mRNA

NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287

G

calreticulin

decreases expression

Clozapine results in decreased expression of CALR protein

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

calumenin

decreases expression

Clozapine results in decreased expression of CALU protein

NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593

G

calcium/calmodulin-dependent protein kinase II alpha

decreases expression
increases expression

Clozapine results in decreased expression of CAMK2A mRNA
Clozapine results in increased expression of CAMK2A mRNA
Clozapine results in decreased expression of CAMK2A protein

PMID:15860345 PMID:17266109 PMID:19289156

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

G

calcium/calmodulin-dependent protein kinase II beta

decreases expression

Clozapine results in decreased expression of CAMK2B mRNA

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

G

calcium/calmodulin-dependent protein kinase II delta

decreases expression

Clozapine results in decreased expression of CAMK2D mRNA

NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178

G

calcium/calmodulin-dependent protein kinase IV

increases expression
decreases expression

Clozapine results in increased expression of CAMK4 mRNA
Clozapine results in decreased expression of CAMK4 protein

PMID:15860345 PMID:19289156

NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487

G

calcium/calmodulin-dependent protein kinase kinase 1

decreases expression

Clozapine results in decreased expression of CAMKK1 protein

NCBI chr10:57,637,335...57,660,498
Ensembl chr10:57,637,391...57,660,498

G

calcium/calmodulin-dependent protein kinase kinase 2

decreases expression

Clozapine results in decreased expression of CAMKK2 protein

NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279

G

calnexin

decreases expression

Clozapine results in decreased expression of CANX protein

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

cysteinyl-tRNA synthetase 1

increases expression

Clozapine results in increased expression of CARS1 protein

NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941

G

CART prepropeptide

decreases expression

Clozapine results in decreased expression of CARTPT mRNA

NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713

G

caspase 1

increases activity

Clozapine results in increased activity of CASP1 protein

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

increases activity
multiple interactions

Clozapine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP3 protein]

PMID:22700542 PMID:24709159

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases activity
multiple interactions

Clozapine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

catalase

multiple interactions

Clozapine inhibits the reaction [Corticosterone results in increased activity of CAT protein]; Clozapine inhibits the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cell division cycle and apoptosis regulator 1

increases expression

Clozapine results in increased expression of CCAR1 protein

NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526

G

coiled-coil domain containing 47

increases expression
multiple interactions

Clozapine results in increased expression of CCDC47 protein
[Cuprizone co-treated with Clozapine] results in increased expression of CCDC47 protein

NCBI chr10:91,130,303...91,148,829
Ensembl chr10:91,130,303...91,148,881

G

cholecystokinin

multiple interactions
increases expression

Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein]
Clozapine results in increased expression of CCK mRNA

PMID:10974607 PMID:16567023

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

cholecystokinin B receptor

increases expression

Clozapine results in increased expression of CCKBR mRNA

NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881

G

C-C motif chemokine ligand 1

decreases expression

Clozapine results in decreased expression of CCL1 mRNA

NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159

G

cyclin D1

decreases expression

Clozapine results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D3

increases expression

Clozapine results in increased expression of CCND3 mRNA

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin L1

increases expression

Clozapine results in increased expression of CCNL1 mRNA

NCBI chr 2:150,184,865...150,199,524
Ensembl chr 2:150,184,798...150,197,368

G

chaperonin containing TCP1 subunit 7

decreases expression

Clozapine results in decreased expression of CCT7 protein

NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580

G

Cd276 molecule

decreases expression

Clozapine results in decreased expression of CD276 protein

NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380

G

Cd63 molecule

increases expression

Clozapine results in increased expression of CD63 protein

NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178

G

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

increases expression

Clozapine results in increased expression of CDIPT protein

NCBI chr 1:181,583,098...181,587,409
Ensembl chr 1:181,583,141...181,587,408

G

cyclin-dependent kinase 4

increases expression

Clozapine results in increased expression of CDK4 mRNA

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 5

increases expression

Clozapine results in increased expression of CDK5 mRNA

NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112

G

cyclin-dependent kinase 5 regulatory subunit 1

increases expression

Clozapine results in increased expression of CDK5R1 mRNA

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

G

CCAAT/enhancer binding protein alpha

multiple interactions
increases expression

Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]
Clozapine results in increased expression of CEBPA mRNA; Clozapine results in increased expression of CEBPA protein

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

centromere protein V

increases expression

Clozapine results in increased expression of CENPV protein

NCBI chr10:47,214,479...47,228,552
Ensembl chr10:47,214,490...47,228,761

G

cilia and flagella associated protein 210

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of CFAP210 protein

NCBI chr 3:54,520,455...54,554,677
Ensembl chr 3:54,520,458...54,554,607

G

coiled-coil-helix-coiled-coil-helix domain containing 2

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of CHCHD2 protein

NCBI chr12:26,828,738...26,834,762
Ensembl chr12:26,828,736...26,834,755

G

chromodomain helicase DNA binding protein 4

decreases expression

Clozapine results in decreased expression of CHD4 protein

NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541

G

chromogranin A

decreases expression
increases expression

Clozapine results in decreased expression of CHGA mRNA
Clozapine results in increased expression of CHGA mRNA

NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398

G

cell adhesion molecule L1-like

decreases expression

Clozapine results in decreased expression of CHL1 mRNA

NCBI chr 4:136,291,504...136,505,830
Ensembl chr 4:136,291,463...136,503,265

G

chimerin 1

decreases expression

Clozapine results in decreased expression of CHN1 mRNA

NCBI chr 3:58,509,822...58,676,462
Ensembl chr 3:58,510,536...58,676,490

G

cysteine and histidine rich domain containing 1

increases expression

Clozapine results in increased expression of CHORDC1 protein

NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162

G

cholinergic receptor, muscarinic 1

affects binding
increases expression
multiple interactions

Clozapine analog binds to CHRM1 protein; Clozapine binds to CHRM1 protein
Clozapine results in increased expression of CHRM1 protein
Clozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein]

PMID:11997696 PMID:16983399 PMID:18806925

NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356

G

cytoskeleton-associated protein 4

increases expression

Clozapine results in increased expression of CKAP4 protein

NCBI chr 7:19,230,814...19,238,914
Ensembl chr 7:19,230,203...19,238,914

G

chloride intracellular channel 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of CLIC1 protein

NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712

G

chloride intracellular channel 4

increases expression

Clozapine results in increased expression of CLIC4 protein

NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452

G

clock circadian regulator

affects response to substance

CLOCK gene SNP affects the susceptibility to Clozapine

NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400

G

clathrin, light chain A

decreases expression

Clozapine results in decreased expression of CLTA mRNA

NCBI chr 5:58,244,253...58,263,480
Ensembl chr 5:58,245,442...58,263,472

G

clathrin, light chain B

decreases expression

Clozapine results in decreased expression of CLTB mRNA

NCBI chr17:10,001,512...10,019,201
Ensembl chr17:10,001,513...10,019,169

G

2',3'-cyclic nucleotide 3' phosphodiesterase

decreases expression
increases expression

Clozapine results in decreased expression of CNP mRNA
Clozapine results in decreased expression of CNP protein
Clozapine results in increased expression of CNP mRNA

PMID:17266109 PMID:34122009

NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720

G

coilin

increases expression

Clozapine results in increased expression of COIL mRNA

NCBI chr10:73,789,077...73,810,378
Ensembl chr10:73,789,488...73,810,393

G

collagen type V alpha 2 chain

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of COL5A2 protein

NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154

G

catechol-O-methyltransferase

multiple interactions
affects response to substance
increases response to substance

[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]
COMT protein affects the susceptibility to Clozapine
COMT gene polymorphism results in increased susceptibility to Clozapine

PMID:15190105 PMID:17123785

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

COP9 signalosome subunit 3

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of COPS3 protein

NCBI chr10:44,618,115...44,652,807
Ensembl chr10:44,618,115...44,641,597

G

coronin 1B

decreases expression

Clozapine results in decreased expression of CORO1B protein

NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416

G

complexin 2

decreases expression

Clozapine results in decreased expression of CPLX2 mRNA

NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855

G

carboxypeptidase N subunit 1

increases expression

Clozapine results in increased expression of CPN1 mRNA

NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465

G

copine 1

decreases expression

Clozapine results in decreased expression of CPNE1 protein

NCBI chr 3:144,587,531...144,629,911
Ensembl chr 3:144,588,995...144,598,636

G

carnitine palmitoyltransferase 2

multiple interactions

[Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

cAMP responsive element binding protein 1

multiple interactions
decreases phosphorylation

Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein]
Clozapine results in decreased phosphorylation of CREB1 protein

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

corticotropin releasing hormone

decreases expression

Clozapine results in decreased expression of CRH mRNA

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

corticotropin releasing hormone binding protein

decreases expression

Clozapine results in decreased expression of CRHBP mRNA

NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710

G

C-reactive protein

increases expression

Clozapine results in increased expression of CRP protein

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

colony stimulating factor 3

multiple interactions

CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA]

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

casein kinase 2 alpha 1

decreases expression

Clozapine results in decreased expression of CSNK2A1 mRNA

NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696

G

cystatin C

increases expression

Clozapine results in increased expression of CST3 mRNA

NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822

G

cleavage stimulation factor subunit 1

decreases expression

Clozapine results in decreased expression of CSTF1 protein

NCBI chr 3:161,144,522...161,156,294
Ensembl chr 3:161,144,548...161,156,300

G

cleavage stimulation factor subunit 2

decreases expression

Clozapine results in decreased expression of CSTF2 protein

NCBI chr X:97,253,559...97,279,476
Ensembl chr X:97,253,586...97,279,476

G

C-terminal binding protein 1

increases expression

Clozapine results in increased expression of CTBP1 protein

NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821

G

catenin beta 1

increases expression
multiple interactions

Clozapine results in increased expression of CTNNB1 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

chymotrypsin-like

increases expression

Clozapine results in increased expression of CTRL mRNA

NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626

G

cathepsin K

increases expression

Clozapine results in increased expression of CTSK mRNA

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cortactin

increases expression

Clozapine results in increased expression of CTTN protein

NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164

G

cullin 2

increases expression

Clozapine results in increased expression of CUL2 protein

NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968

G

cullin 3

increases expression

Clozapine results in increased expression of CUL3 protein

NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462

G

C-X-C motif chemokine ligand 1

decreases expression
decreases secretion
multiple interactions
increases secretion

Clozapine results in decreased expression of CXCL1 mRNA
Clozapine results in decreased secretion of CXCL1 protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of CXCL1 protein]

PMID:17346280 PMID:34935985 PMID:36482696

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

decreases secretion

Clozapine results in decreased secretion of CXCL10 protein

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 3

decreases expression
decreases secretion

Clozapine results in decreased expression of CXCL1 mRNA
Clozapine results in decreased secretion of CXCL1 protein

PMID:17346280 PMID:36482696

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

similar to human chromosome X open reading frame 49

increases expression

Clozapine results in increased expression of CXORF49 protein

NCBI chr X:66,911,430...66,915,407
Ensembl chr X:66,911,431...66,915,293

G

cytochrome b5 type B

increases expression

Clozapine results in increased expression of CYB5B mRNA

NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249

G

cytochrome b5 reductase 1

increases expression

Clozapine results in increased expression of CYB5R1 protein

NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
increases metabolic processing

Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Clozapine results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of Clozapine

PMID:18493746 PMID:18809730 PMID:33814510

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases response to substance
multiple interactions
increases metabolic processing
increases expression
affects metabolic processing
affects response to substance
decreases metabolic processing

CYP1A2 gene SNP results in decreased susceptibility to Clozapine
Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CYP1A2 protein results in increased metabolism of Clozapine
Clozapine results in increased expression of CYP1A2 mRNA
CYP1A2 gene polymorphism affects the metabolism of Clozapine; CYP1A2 protein affects the metabolism of Clozapine; CYP1A2 protein polymorphism affects the metabolism of Clozapine
[Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Smoke affects the reaction [CYP1A2 gene polymorphism affects the metabolism of Clozapine]; Smoke promotes the reaction [CYP1A2 protein results in increased metabolism of Clozapine]
CYP1A2 gene SNP affects the susceptibility to Clozapine; CYP1A2 protein affects the susceptibility to Clozapine
CYP1A2 gene SNP results in increased metabolism of Clozapine; CYP1A2 protein results in increased metabolism of Clozapine
CYP1A2 gene SNP results in decreased metabolism of Clozapine

PMID:11151749 PMID:11763009 PMID:12919186 PMID:12969762 PMID:15206669 More...

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases metabolic processing
decreases activity

CYP1B1 protein results in increased metabolism of Clozapine
Clozapine results in decreased activity of CYP1B1 protein

PMID:18809730 PMID:33814510

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
increases metabolic processing

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine
CYP2C19 protein results in increased metabolism of Clozapine

PMID:18809730 PMID:23397584 PMID:27320963

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

increases metabolic processing

CYP2C8 protein results in increased metabolism of Clozapine

PMID:18809730 PMID:27320963

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing
increases metabolic processing
multiple interactions

CYP2D6 protein affects the metabolism of Clozapine
CYP2D6 protein results in increased metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine

PMID:15286053 PMID:18809730 PMID:23397584 PMID:27320963

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily j, polypeptide 4

increases metabolic processing

CYP2J2 protein results in increased metabolism of Clozapine

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases metabolic processing
affects metabolic processing
multiple interactions

CYP3A4 protein results in increased metabolism of Clozapine
CYP3A4 protein affects the metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]

PMID:15286053 PMID:18809730 PMID:21402137 PMID:23397584 PMID:27320963

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases metabolic processing

CYP3A5 protein results in increased metabolism of Clozapine

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

DAB adaptor protein 1

increases expression

Clozapine results in increased expression of DAB1 mRNA

NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552

G

DAB adaptor protein 2

increases expression

Clozapine results in increased expression of DAB2 protein

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

diacylglycerol lipase, beta

increases expression

Clozapine results in increased expression of DAGLB protein

NCBI chr12:11,059,732...11,102,170
Ensembl chr12:11,059,732...11,102,154

G

DDB1 and CUL4 associated factor 6

decreases expression

Clozapine results in decreased expression of DCAF6 mRNA

NCBI chr13:77,626,257...77,727,645
Ensembl chr13:77,626,307...77,727,512

G

doublecortin-like kinase 1

increases expression

Clozapine results in increased expression of DCLK1 mRNA

PMID:15860345 PMID:18797397

NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956

G

dopa decarboxylase

multiple interactions
increases expression

Clozapine results in increased expression of and results in increased activity of DDC protein
Clozapine results in increased expression of DDC mRNA

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

DEAD-box helicase 46

increases expression

Clozapine results in increased expression of DDX46 protein

NCBI chr17:8,942,070...8,988,440
Ensembl chr17:8,944,454...8,988,439

G

DENN domain containing 10

increases expression

Clozapine results in increased expression of DENND10 mRNA

NCBI chr 1:259,950,955...259,974,459
Ensembl chr 1:259,950,866...259,974,455

G

DEPP autophagy regulator 1

increases expression

Clozapine results in increased expression of DEPP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

DiGeorge syndrome critical region gene 6

decreases expression

Clozapine results in decreased expression of DGCR6 protein

NCBI chr11:82,927,725...82,932,823
Ensembl chr11:82,927,725...82,932,823

G

diacylglycerol kinase, alpha

decreases expression

Clozapine results in decreased expression of DGKA mRNA

NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110

G

24-dehydrocholesterol reductase

increases expression

Clozapine results in increased expression of DHCR24 protein

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

7-dehydrocholesterol reductase

increases expression

Clozapine results in increased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

DExH-box helicase 30

increases expression

Clozapine results in increased expression of DHX30 protein

NCBI chr 8:110,064,751...110,096,954
Ensembl chr 8:110,064,752...110,097,381

G

DEAH-box helicase 38

decreases expression

Clozapine results in decreased expression of DHX38 protein

NCBI chr19:37,512,893...37,530,135
Ensembl chr19:37,512,891...37,530,140

G

DISC1 scaffold protein

decreases response to substance
affects response to substance

DISC1 gene mutant form results in decreased susceptibility to Clozapine
DISC1 protein affects the susceptibility to Clozapine

NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778

G

dihydrolipoamide S-acetyltransferase

decreases expression
increases expression

Clozapine results in decreased expression of DLAT mRNA
Clozapine results in increased expression of DLAT protein

PMID:15860345 PMID:34122009

NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
Ensembl chr 1:50,978,051...51,004,479

G

discs large MAGUK scaffold protein 2

increases expression

Clozapine results in increased expression of DLG2 protein

NCBI chr 1:144,451,653...146,503,949
Ensembl chr 1:144,451,472...146,499,475

G

dihydrolipoamide S-succinyltransferase

decreases expression

Clozapine results in decreased expression of DLST protein

NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296

G

dynein, axonemal, heavy chain 11

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of DNAH11 protein

NCBI chr 6:138,839,175...139,155,554
Ensembl chr 6:138,839,177...139,155,536

G

DnaJ heat shock protein family (Hsp40) member A3

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of DNAJA3 protein

NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161

G

DnaJ heat shock protein family (Hsp40) member B11

increases expression

Clozapine results in increased expression of DNAJB11 protein

NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407

G

double PHD fingers 1

affects expression

Clozapine affects the expression of DPF1 mRNA

NCBI chr 1:84,602,212...84,615,954
Ensembl chr 1:84,602,336...84,615,950

G

dipeptidylpeptidase 3

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of DPP3 protein

NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541

G

dihydropyrimidinase-like 3

decreases expression

Clozapine results in decreased expression of DPYSL3 protein

NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157

G

dihydropyrimidinase-like 4

decreases expression

Clozapine results in decreased expression of DPYSL4 protein

NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914

G

down-regulator of transcription 1

decreases expression

Clozapine results in decreased expression of DR1 protein

NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638

G

dopamine receptor D1

affects binding
decreases expression
affects response to substance

Clozapine binds to DRD1 protein
Clozapine results in decreased expression of DRD1 mRNA
Clozapine analog binds to DRD1 protein
DRD1 gene polymorphism affects the susceptibility to Clozapine; DRD1 protein affects the susceptibility to Clozapine

PMID:1352677 PMID:9723970 PMID:11997696 PMID:17092969 PMID:17266109

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

multiple interactions
affects binding
affects response to substance
decreases expression
increases response to substance

[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein
Clozapine binds to DRD2 protein
DRD2 protein affects the susceptibility to Clozapine
Clozapine results in decreased expression of DRD2 mRNA
Clozapine analog binds to DRD2 protein; Clozapine binds to DRD2 protein
[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]; Clozapine binds to and results in decreased activity of DRD2 protein; Clozapine promotes the reaction [Dopamine binds to DRD2 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]
[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA
Clozapine binds to DRD2 protein alternative form
DRD2 gene SNP results in increased susceptibility to Clozapine
DRD2 gene affects the susceptibility to Clozapine; DRD2 gene polymorphism affects the susceptibility to Clozapine

PMID:1352677 PMID:9723970 PMID:11997696 PMID:12476322 PMID:15286066 More...

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

affects response to substance
multiple interactions
decreases response to substance

DRD3 protein affects the susceptibility to Clozapine
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
DRD3 gene polymorphism results in decreased susceptibility to Clozapine

PMID:15579174 PMID:20029384

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

dopamine receptor D4

affects binding
multiple interactions
affects response to substance

Clozapine binds to DRD4 protein
Clozapine binds to Drd4 protein
Clozapine inhibits the reaction [Dopamine results in increased activity of DRD4 protein]
Clozapine analog binds to DRD4 protein
DRD4 gene polymorphism affects the susceptibility to Clozapine

CTD
RGD

PMID:11997696 PMID:16223700 PMID:31323226 PMID:8078498

NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553

G

dystrophin related protein 2

increases expression

Clozapine results in increased expression of DRP2 mRNA alternative form

NCBI chr X:97,607,577...97,658,117
Ensembl chr X:97,607,719...97,655,684

G

dystrobrevin binding protein 1

increases response to substance
affects response to substance

DTNBP1 gene polymorphism results in increased susceptibility to Clozapine
DTNBP1 protein affects the susceptibility to Clozapine

NCBI chr17:19,685,218...19,776,668
Ensembl chr17:19,685,215...19,776,661

G

dual specificity phosphatase 1

decreases expression

Clozapine results in decreased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 6

decreases expression

Clozapine results in decreased expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

dishevelled segment polarity protein 3

increases expression
multiple interactions

Clozapine results in increased expression of DVL3 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]

NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462

G

dynein cytoplasmic 1 light intermediate chain 1

decreases expression

Clozapine results in decreased expression of DYNC1LI1 protein

NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934

G

dynein, cytoplasmic 1 light intermediate chain 2

decreases expression

Clozapine results in decreased expression of DYNC1LI2 protein

NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670

G

enhancer of mRNA decapping 4

increases expression

Clozapine results in increased expression of EDC4 protein

NCBI chr19:33,774,062...33,786,054
Ensembl chr19:33,774,055...33,787,758

G

eukaryotic translation elongation factor 1 alpha 2

increases expression

Clozapine results in increased expression of EEF1A2 protein

NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071

G

eukaryotic translation elongation factor 1 delta

decreases expression

Clozapine results in decreased expression of EEF1D protein

NCBI chr 7:107,581,930...107,596,735
Ensembl chr 7:107,581,930...107,608,799

G

early growth response 1

decreases expression

Clozapine results in decreased expression of EGR1 mRNA; Clozapine results in decreased expression of EGR1 protein

PMID:17028028 PMID:18208916

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

affects expression
decreases expression

Clozapine affects the expression of EGR2 mRNA
Clozapine results in decreased expression of EGR2 protein

PMID:17028028 PMID:19401217

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

G

early growth response 3

affects response to substance

EGR3 protein affects the susceptibility to Clozapine

NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627

G

eukaryotic translation initiation factor 2 subunit gamma

increases expression

Clozapine results in increased expression of EIF2S3 protein

NCBI chr X:58,916,513...58,939,923
Ensembl chr X:58,917,490...58,940,686

G

eukaryotic translation initiation factor 3, subunit C

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of EIF3C protein

NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493

G

eukaryotic translation initiation factor 3, subunit J

increases expression

Clozapine results in increased expression of EIF3J protein

NCBI chr 3:108,985,103...109,007,341
Ensembl chr 3:108,985,118...109,007,953

G

eukaryotic translation initiation factor 3, subunit M

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of EIF3M protein

NCBI chr 3:91,424,754...91,442,358
Ensembl chr 3:91,416,325...91,442,392

G

eukaryotic translation initiation factor 4A3

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of EIF4A3 protein

NCBI chr10:104,549,038...104,559,032
Ensembl chr10:104,549,038...104,559,057

G

eukaryotic translation initiation factor 4E

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of EIF4E protein

NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683

G

eukaryotic translation initiation factor 5B

increases expression

Clozapine results in increased expression of EIF5B protein

NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482

G

eukaryotic translation initiation factor 6

decreases expression

Clozapine results in decreased expression of EIF6 protein

NCBI chr 3:144,325,038...144,331,396
Ensembl chr 3:144,325,036...144,331,401

G

ETS transcription factor ELK1

decreases phosphorylation

Clozapine results in decreased phosphorylation of ELK1 protein

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

enolase 1

increases expression

Clozapine results in increased expression of ENO1 mRNA

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

enolase 3

increases expression

Clozapine results in increased expression of ENO3 protein

NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921

G

Eph receptor A7

increases expression

Clozapine results in increased expression of EPHA7 mRNA

NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112

G

Eph receptor B3

increases expression

Clozapine results in increased expression of EPHB3 protein

NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370

G

endoplasmic reticulum aminopeptidase 1

decreases expression

Clozapine results in decreased expression of ERAP1 protein

NCBI chr 2:3,931,817...3,970,735
Ensembl chr 2:3,931,904...3,972,447

G

erb-b2 receptor tyrosine kinase 2

affects phosphorylation

Clozapine affects the phosphorylation of ERBB2 protein

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 4

multiple interactions

Clozapine results in increased expression of and results in increased phosphorylation of ERBB4 protein

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

ERH, mRNA splicing and mitosis factor

increases expression

Clozapine results in increased expression of ERH protein

NCBI chr 6:100,280,933...100,291,200
Ensembl chr 6:100,280,930...100,291,210

G

endoplasmic reticulum protein 44

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of ERP44 protein

NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761

G

EWS RNA-binding protein 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of EWSR1 protein

NCBI chr14:79,965,365...79,994,108
Ensembl chr14:79,965,368...79,994,544

G

exosome component 4

increases expression

Clozapine results in increased expression of EXOSC4 protein

NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573

G

ezrin

decreases expression

Clozapine results in decreased expression of EZR protein

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

fatty acid binding protein 1

increases expression

Clozapine results in increased expression of FABP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

FANCD2 and FANCI associated nuclease 1

increases expression

Clozapine results in increased expression of FAN1 protein

NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977

G

phenylalanyl-tRNA synthetase subunit alpha

increases expression

Clozapine results in increased expression of FARSA protein

NCBI chr19:23,291,409...23,300,985
Ensembl chr19:23,268,869...23,300,980

G

phenylalanyl-tRNA synthetase subunit beta

increases expression

Clozapine results in increased expression of FARSB protein

NCBI chr 9:79,887,852...79,947,082
Ensembl chr 9:79,887,842...79,947,045

G

Fas cell surface death receptor

multiple interactions

[Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

multiple interactions

[Clozapine analog co-treated with Hydrogen Peroxide] results in increased expression of FASLG mRNA; [Clozapine co-treated with Hydrogen Peroxide co-treated with Tretinoin] results in increased expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

increases expression

Clozapine results in increased expression of FASN mRNA

PMID:16027736 PMID:17052361

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

farnesyl diphosphate synthase

increases expression

Clozapine results in increased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

flap structure-specific endonuclease 1

increases expression

Clozapine results in increased expression of FEN1 protein

NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003

G

fibroblast growth factor 2

increases expression

Clozapine results in increased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibrinogen-like 1

increases expression

Clozapine results in increased expression of FGL1 protein

NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093

G

formin homology 2 domain containing 1

decreases expression

Clozapine results in decreased expression of FHOD1 protein

NCBI chr19:33,206,492...33,225,448
Ensembl chr19:33,206,492...33,225,356

G

FKBP prolyl isomerase 8

decreases expression

Clozapine results in decreased expression of FKBP8 protein

NCBI chr16:18,895,608...18,902,648
Ensembl chr16:18,893,576...18,902,612

G

flotillin 2

increases expression

Clozapine results in increased expression of FLOT2 protein

NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756

G

flavin containing dimethylaniline monoxygenase 1

increases metabolic processing

FMO1 protein results in increased metabolism of Clozapine

NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647

G

flavin containing dimethylaniline monoxygenase 3

increases metabolic processing

FMO3 protein results in increased metabolism of Clozapine

PMID:18809730 PMID:27320963

NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028

G

fibronectin type III domain containing 4

increases expression

Clozapine results in increased expression of FNDC4 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression
decreases expression

Clozapine affects the reaction [Haloperidol results in increased expression of FOS protein]; Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA]
Clozapine results in increased expression of FOS protein
Clozapine analog results in increased expression of FOS protein; Clozapine results in increased expression of FOS mRNA; Clozapine results in increased expression of FOS protein
Clozapine results in decreased expression of FOS protein

PMID:10435392 PMID:11166331 PMID:11440804 PMID:11997696 PMID:12093589 More...

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions
decreases expression

Clozapine results in increased expression of FOSB protein alternative form
Clozapine results in increased expression of FOSB mRNA; Clozapine results in increased expression of FOSB protein
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
Clozapine results in decreased expression of FOSB mRNA

PMID:11259127 PMID:12093589 PMID:12243769 PMID:15579174 PMID:19695244

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

FOS like 1, AP-1 transcription factor subunit

increases expression

Clozapine results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

FOS like 2, AP-1 transcription factor subunit

increases expression

Clozapine results in increased expression of FOSL2 mRNA

PMID:12093589 PMID:12243769

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

G

forkhead box P2

increases expression

Clozapine results in increased expression of FOXP2 mRNA

NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683

G

follistatin-like 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of FSTL1 protein

NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677

G

far upstream element binding protein 1

increases expression

Clozapine results in increased expression of FUBP1 protein

NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602

G

glucose-6-phosphate dehydrogenase

decreases expression

Clozapine results in decreased expression of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

GABA type A receptor associated protein like 2

increases expression

Clozapine results in increased expression of GABARAPL2 protein

NCBI chr19:39,910,572...39,921,408
Ensembl chr19:39,910,534...39,924,628

G

gamma-aminobutyric acid type B receptor subunit 1

decreases expression

Clozapine results in decreased expression of GABBR1 mRNA

NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994

G

gamma-aminobutyric acid type A receptor subunit alpha 1

increases expression

Clozapine results in increased expression of GABRA1 mRNA

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit beta 3

increases expression

Clozapine results in increased expression of GABRB3 mRNA

NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961

G

glutamate decarboxylase 1

increases expression
decreases methylation
multiple interactions

Clozapine results in increased expression of GAD1 mRNA
Clozapine results in decreased methylation of GAD1 promoter
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]; Valproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter]

PMID:12887421 PMID:15061247 PMID:17942719 PMID:18757738 PMID:18923069

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

glutamate decarboxylase 2

increases expression

Clozapine results in increased expression of GAD2 mRNA

PMID:17266109 PMID:18923069

NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

Clozapine results in increased expression of GAPDH mRNA
Clozapine results in increased expression of GAPDH protein

PMID:15860345 PMID:34122009

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

increases expression

Clozapine results in increased expression of GART protein

NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125

G

glycine amidinotransferase

increases expression

Clozapine results in increased expression of GATM protein

NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129

G

GRIP and coiled-coil domain containing 2

decreases expression

Clozapine results in decreased expression of GCC2 protein

NCBI chr20:26,247,394...26,293,613
Ensembl chr20:26,247,404...26,293,613

G

growth differentiation factor 15

increases expression

Clozapine results in increased expression of GDF15 protein

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glycerophosphodiester phosphodiesterase domain containing 3

increases expression

Clozapine results in increased expression of GDPD3 mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063

G

glial fibrillary acidic protein

decreases expression
increases expression

Clozapine results in decreased expression of GFAP protein
Clozapine results in increased expression of GFAP mRNA

PMID:18585900 PMID:19441803

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

growth hormone inducible transmembrane protein

increases expression

Clozapine results in increased expression of GHITM protein

NCBI chr16:12,885,551...12,897,887
Ensembl chr16:12,885,553...12,897,879

G

GTPase, IMAP family member 5

decreases expression

Clozapine results in decreased expression of GIMAP5 mRNA

NCBI chr 4:77,693,417...77,701,025
Ensembl chr 4:77,687,564...77,703,086

G

gastric inhibitory polypeptide

increases expression

Clozapine results in increased expression of GIP mRNA; Clozapine results in increased expression of GIP protein

NCBI chr10:80,968,360...80,976,506
Ensembl chr10:80,968,352...80,976,503

G

gap junction protein, alpha 1

increases expression

Clozapine results in increased expression of GJA1 protein

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glucagon-like peptide 1 receptor

multiple interactions
decreases expression

PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein]

NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241

G

glutaredoxin 3

increases expression

Clozapine results in increased expression of GLRX3 protein

NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010

G

glutamate-ammonia ligase

decreases expression

Clozapine results in decreased expression of GLUL protein

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

G protein subunit alpha 12

decreases expression
increases expression

Clozapine results in decreased expression of GNA12 mRNA
Clozapine results in increased expression of GNA12 protein

PMID:15860345 PMID:34122009

NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255

G

G protein subunit alpha i1

decreases expression

Clozapine results in decreased expression of GNAI1 mRNA

NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417

G

G protein subunit alpha i2

decreases expression

Clozapine results in decreased expression of GNAI2 mRNA

NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979

G

G protein subunit alpha i3

decreases expression

Clozapine results in decreased expression of GNAI3 mRNA

NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742

G

GNAS complex locus

decreases expression
multiple interactions
increases expression

Clozapine results in decreased expression of GNAS mRNA
[Cuprizone co-treated with Clozapine] results in decreased expression of GNAS protein
Clozapine results in increased expression of GNAS protein

PMID:15860345 PMID:34122009

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

G protein subunit beta 3

decreases response to substance
increases expression
affects response to substance
increases response to substance

GNB3 gene polymorphism results in decreased susceptibility to Clozapine
Clozapine results in increased expression of GNB3 protein
GNB3 protein affects the susceptibility to Clozapine
GNB3 gene polymorphism results in increased susceptibility to Clozapine

PMID:16139171 PMID:16141801 PMID:18855531

NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173

G

golgin A3

increases expression

Clozapine results in increased expression of GOLGA3 protein

NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509
Ensembl chr 4:46,454,870...46,500,509

G

golgin B1

increases expression

Clozapine results in increased expression of GOLGB1 protein

NCBI chr11:63,843,179...63,900,665
Ensembl chr11:63,843,986...63,900,770

G

glutamic-oxaloacetic transaminase 2

increases expression
multiple interactions

Clozapine results in increased expression of GOT2 mRNA
[Cuprizone co-treated with Clozapine] results in increased expression of GOT2 protein

PMID:15860345 PMID:34122009

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

glycerol-3-phosphate dehydrogenase 2

decreases expression

Clozapine results in decreased expression of GPD2 protein

NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901

G

glucose-6-phosphate isomerase

increases expression

Clozapine results in increased expression of GPI protein

NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086

G

glutamic--pyruvic transaminase

multiple interactions

[Chloroquine co-treated with Clozapine] results in increased secretion of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

increases expression

Clozapine results in increased expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutamate ionotropic receptor kainate type subunit 2

increases expression

Clozapine results in increased expression of GRIK2 mRNA

NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375

G

glutamate ionotropic receptor kainate type subunit 5

affects expression
decreases expression

Clozapine affects the expression of GRIK5 mRNA
Clozapine results in decreased expression of GRIK5 mRNA

PMID:14647396 PMID:18923069

NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125

G

glutamate ionotropic receptor NMDA type subunit 1

decreases expression
increases expression

Clozapine results in decreased expression of GRIN1 mRNA
Clozapine results in increased expression of GRIN1 mRNA

PMID:12020038 PMID:12608697 PMID:17266109 PMID:18923069

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2A

decreases expression

Clozapine results in decreased expression of GRIN2A mRNA

PMID:12608697 PMID:18923069

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2B

decreases expression

Clozapine results in decreased expression of GRIN2B mRNA

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

glutamate ionotropic receptor NMDA type subunit 2C

decreases expression

Clozapine results in decreased expression of GRIN2C mRNA

NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427

G

G protein-coupled receptor kinase 6

decreases expression

Clozapine results in decreased expression of GRK6 mRNA

NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644

G

glycogen synthase kinase 3 alpha

increases expression
multiple interactions

Clozapine results in increased expression of GSK3A protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]

NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802

G

glycogen synthase kinase 3 beta

increases phosphorylation
increases expression
multiple interactions

Clozapine results in increased phosphorylation of GSK3B protein
Clozapine results in increased expression of GSK3B protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]

PMID:16144542 PMID:19359144 PMID:19440698

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione S-transferase alpha 1

decreases activity
increases glutathionylation

GSTA1 protein results in decreased activity of Clozapine
GSTA1 protein results in increased glutathionylation of Clozapine

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase mu 1

decreases activity
increases expression
increases glutathionylation

GSTM1 protein results in decreased activity of Clozapine
Clozapine results in increased expression of GSTM1 mRNA
GSTM1 protein results in increased glutathionylation of Clozapine

PMID:15860345 PMID:20849150

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

decreases expression

Clozapine results in decreased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

decreases activity
affects metabolic processing
increases glutathionylation
affects binding

Clozapine metabolite results in decreased activity of GSTP1 protein; GSTP1 protein results in decreased activity of Clozapine
GSTP1 protein affects the metabolism of Clozapine metabolite
GSTP1 protein results in increased glutathionylation of Clozapine
Clozapine metabolite binds to GSTP1 protein

PMID:20849150 PMID:21639118 PMID:24185126

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

H1.2 linker histone, cluster member

increases expression

Clozapine results in increased expression of H1-2 protein

NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635

G

H2A clustered histone 18

increases expression

Clozapine results in increased expression of H2AC18 mRNA

NCBI chr 2:183,808,398...183,808,992

G

H2A clustered histone 20

increases expression

Clozapine results in increased expression of H2AC20 protein

NCBI chr 2:183,779,879...183,780,357

G

H2A.J histone

increases expression

Clozapine results in increased expression of H2AJ protein

NCBI chr 4:169,675,718...169,676,202
Ensembl chr 4:169,675,752...169,677,006

G

3-hydroxyanthranilate 3,4-dioxygenase

decreases expression

Clozapine results in decreased expression of HAAO protein

NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877

G

3-hydroxyacyl-CoA dehydratase 3

increases expression

Clozapine results in increased expression of HACD3 protein

NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

Clozapine results in increased expression of HADHB protein

NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869

G

histidyl-tRNA synthetase 1

increases expression

Clozapine results in increased expression of HARS1 protein

NCBI chr18:28,381,649...28,398,699
Ensembl chr18:28,381,655...28,398,740

G

histone acetyltransferase 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of HAT1 protein

NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517

G

hematopoietic cell specific Lyn substrate 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of HCLS1 protein

NCBI chr11:63,817,482...63,840,943
Ensembl chr11:63,817,476...63,841,014

G

HDGF like 2

increases expression

Clozapine results in increased expression of HDGFRP2 protein

NCBI chr 9:909,581...929,195
Ensembl chr 9:909,614...929,186

G

HIG1 hypoxia inducible domain family, member 1A

increases expression

Clozapine results in increased expression of HIGD1A mRNA

NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:121,514,156...121,523,443

G

high mobility group box 2

increases expression

Clozapine results in increased expression of HMGB2 protein

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
Ensembl chr 1:32,710,658...32,713,140

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions
increases expression
increases activity

[Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides
Clozapine results in increased expression of HMGCR mRNA

PMID:16027736 PMID:17052361

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

Clozapine results in increased expression of HMGCS1 mRNA

PMID:16027736 PMID:17052361

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

heme oxygenase 1

increases expression

Clozapine results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein D

decreases expression

Clozapine results in decreased expression of HNRNPD protein

NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786

G

heterogeneous nuclear ribonucleoprotein H2

decreases expression

Clozapine results in decreased expression of HNRNPH2 protein

NCBI chr X:97,780,890...97,786,846
Ensembl chr X:97,780,785...97,787,041

G

homer scaffold protein 1

increases expression
multiple interactions

Clozapine results in increased expression of HOMER1 mRNA
Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]

PMID:12464447 PMID:15860345

NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785

G

hippocalcin-like 1

decreases expression

Clozapine results in decreased expression of HPCAL1 mRNA

NCBI chr 6:40,478,206...40,584,721
Ensembl chr 6:40,478,208...40,584,687

G

hippocalcin-like 4

affects expression

Clozapine affects the expression of HPCAL4 mRNA

NCBI chr 5:135,454,477...135,466,417
Ensembl chr 5:135,454,540...135,466,416

G

hepsin

increases expression

Clozapine results in increased expression of HPN mRNA

NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811

G

histamine receptor H 1

affects binding

Clozapine binds to HRH1 protein

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

histamine receptor H3

multiple interactions

Clozapine binds to Hrh3 protein; Clozapine inhibits the reaction [N-methylhistamine binds to Hrh3 protein]

RGD

NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642

G

hydroxysteroid (17-beta) dehydrogenase 10

decreases expression

Clozapine results in decreased expression of HSD17B10 protein

NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488

G

hydroxysteroid (17-beta) dehydrogenase 12

increases expression

Clozapine results in increased expression of HSD17B12 protein

NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617

G

heat shock protein family A (Hsp70) member 9

decreases expression

Clozapine results in decreased expression of HSPA9 protein

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

5-hydroxytryptamine receptor 1A

multiple interactions
affects binding

Clozapine binds to and affects the activity of HTR1A protein
Clozapine binds to HTR1A protein

PMID:9723970 PMID:15482641

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

G

5-hydroxytryptamine receptor 1D

decreases expression

Clozapine results in decreased expression of HTR1D mRNA

NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:148,674,495...148,675,619

G

5-hydroxytryptamine receptor 2A

increases response to substance
affects binding
multiple interactions
decreases expression
decreases activity
affects response to substance
increases expression

HTR2A gene SNP results in increased susceptibility to Clozapine
Clozapine analog binds to HTR2A protein; Clozapine binds to HTR2A protein
Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein]
Clozapine results in decreased expression of HTR2A mRNA; Clozapine results in decreased expression of HTR2A protein
Clozapine results in decreased activity of HTR2A protein
[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]; Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein]
HTR2A protein affects the susceptibility to Clozapine
Clozapine results in increased expression of HTR2A mRNA

PMID:7520908 PMID:9723970 PMID:11997696 PMID:14751426 PMID:15380371 More...

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

5-hydroxytryptamine receptor 2C

affects binding
decreases expression
affects response to substance

Clozapine binds to HTR2C protein
Clozapine results in decreased expression of HTR2C mRNA
HTR2C gene polymorphism affects the susceptibility to Clozapine; HTR2C gene SNP affects the susceptibility to Clozapine; HTR2C promoter SNP affects the susceptibility to Clozapine; HTR2C protein affects the susceptibility to Clozapine

PMID:9723970 PMID:12668355 PMID:15635667 PMID:16983399 PMID:17868938 More...

NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287

G

5-hydroxytryptamine receptor 3A

multiple interactions
affects response to substance

Clozapine binds to and results in decreased activity of HTR3A protein
HTR3A protein affects the susceptibility to Clozapine

PMID:19696922 PMID:20168265

NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389

G

5-hydroxytryptamine receptor 6

multiple interactions
affects binding

Clozapine binds to and results in decreased activity of HTR6 protein
[Cuprizone co-treated with Clozapine] results in increased expression of HTR6 protein
Clozapine binds to HTR6 protein

PMID:11406289 PMID:16983399 PMID:34122009

NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912

G

5-hydroxytryptamine receptor 7

affects binding
multiple interactions

Clozapine binds to HTR7 protein
[Clozapine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Clozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]

PMID:14578406 PMID:20827463

NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626

G

inhibitor of DNA binding 2

increases expression

Clozapine results in increased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of IDH2 protein

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

Clozapine results in decreased expression of IDI1 protein

NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357

G

interferon gamma

affects expression
decreases expression

Clozapine affects the expression of IFNG protein
Clozapine results in decreased expression of IFNG mRNA

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon gamma receptor 1

increases expression

Clozapine results in increased expression of IFNGR1 protein

NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785

G

insulin-like growth factor 1

decreases expression

Clozapine results in decreased expression of IGF1 protein

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein 1

increases expression

Clozapine results in increased expression of IGFBP1 protein

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

interleukin 10

decreases expression

Clozapine results in decreased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

increases secretion
multiple interactions

Clozapine results in increased secretion of IL1B protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2 receptor subunit alpha

increases secretion

Clozapine results in increased secretion of IL2RA protein

NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697

G

interleukin 5

affects expression

Clozapine affects the expression of IL5 protein

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

ILK associated serine/threonine phosphatase

decreases expression

Clozapine results in decreased expression of ILKAP mRNA

NCBI chr 9:91,966,440...91,988,791
Ensembl chr 9:91,966,441...91,988,892

G

inhibin subunit alpha

decreases expression

Clozapine results in decreased expression of INHA mRNA

NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248

G

inhibin subunit beta E

increases expression

Clozapine results in increased expression of INHBE mRNA

PMID:15342952 PMID:17175557

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

insulin 2

affects secretion
increases expression

Clozapine affects the secretion of INS protein
Clozapine results in increased expression of INS protein

PMID:11769361 PMID:16601995

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

integrin subunit alpha 6

increases expression

Clozapine results in increased expression of ITGA6 protein

NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428

G

Janus kinase 1

increases expression

Clozapine results in increased expression of JAK1 protein

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 2

multiple interactions

[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
increases expression

Clozapine results in decreased expression of JUN mRNA
Clozapine results in increased expression of JUN mRNA

PMID:12093589 PMID:15860345 PMID:18208916

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

Clozapine results in increased expression of JUNB mRNA

PMID:12093589 PMID:19695244

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

JunD proto-oncogene, AP-1 transcription factor subunit

decreases expression

Clozapine results in decreased expression of JUND mRNA

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

potassium voltage-gated channel subfamily A member 1

increases expression

Clozapine results in increased expression of KCNA1 mRNA

NCBI chr 4:159,464,223...159,472,905
Ensembl chr 4:159,464,188...159,472,682

G

potassium voltage-gated channel subfamily H member 2

multiple interactions

Clozapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium voltage-gated channel interacting protein 3

decreases expression
increases expression

Clozapine results in decreased expression of KCNIP3 mRNA
Clozapine results in increased expression of KCNIP3 mRNA

PMID:17266109 PMID:18797397

NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:114,677,030...114,743,556

G

potassium two pore domain channel subfamily K member 2

decreases expression

Clozapine results in decreased expression of KCNK2 mRNA

NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435

G

potassium channel tetramerization domain containing 12

decreases expression

Clozapine results in decreased expression of KCTD12 protein

NCBI chr15:79,800,078...79,806,017
Ensembl chr15:79,801,191...79,806,282

G

kinase insert domain receptor

increases expression

Clozapine results in increased expression of KDR protein

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

KH RNA binding domain containing, signal transduction associated 1

decreases expression

Clozapine results in decreased expression of KHDRBS1 protein

NCBI chr 5:142,051,844...142,089,175
Ensembl chr 5:142,063,570...142,089,180

G

kinesin family member 13B

increases expression

Clozapine results in increased expression of KIF13B protein

NCBI chr15:38,908,257...39,066,021
Ensembl chr15:38,924,624...39,084,879

G

kinesin family member 5C

decreases expression

Clozapine results in decreased expression of KIF5C protein

NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413

G

kizuna centrosomal protein

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of KIZ protein

NCBI chr 3:134,277,631...134,385,260
Ensembl chr 3:134,277,687...134,385,190

G

kelch domain containing 2

decreases expression

Clozapine results in decreased expression of KLHDC2 protein

NCBI chr 6:87,777,183...87,791,609
Ensembl chr 6:87,777,183...87,804,187

G

lysine methyltransferase 2A

increases expression
decreases expression
multiple interactions

Clozapine results in increased expression of KMT2A mRNA
Clozapine results in decreased expression of KMT2A mRNA
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]

PMID:14647396 PMID:17942719

NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181

G

karyopherin subunit alpha 4

multiple interactions
increases expression

[Cuprizone co-treated with Clozapine] results in increased expression of KPNA4 protein
Clozapine results in increased expression of KPNA4 protein

NCBI chr 2:153,319,380...153,381,085
Ensembl chr 2:153,324,273...153,381,081

G

kringle containing transmembrane protein 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of KREMEN1 protein

NCBI chr14:80,081,870...80,147,489
Ensembl chr14:80,084,403...80,147,516

G

lactamase, beta 2

increases expression

Clozapine results in increased expression of LACTB2 protein

NCBI chr 5:5,569,080...5,591,843
Ensembl chr 5:5,569,067...5,596,429

G

lysosomal-associated membrane protein 1

increases expression

Clozapine results in increased expression of LAMP1 protein

NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883

G

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

increases expression

Clozapine results in increased expression of LAMTOR3 mRNA

NCBI chr 2:226,411,389...226,423,612
Ensembl chr 2:226,411,400...226,423,607

G

La ribonucleoprotein 7, transcriptional regulator

increases expression

Clozapine results in increased expression of LARP7 protein

NCBI chr 2:215,997,641...216,012,833
Ensembl chr 2:215,997,649...216,012,865

G

lipocalin 1

decreases expression

Clozapine results in decreased expression of LCN1 protein

NCBI chr 3:9,532,860...9,537,859
Ensembl chr 3:9,532,915...9,536,577

G

lactate dehydrogenase B

increases expression

Clozapine results in increased expression of LDHB mRNA

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

low density lipoprotein receptor

increases expression
multiple interactions

Clozapine results in increased expression of LDLR mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]

PMID:17052361 PMID:20564506

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

liver enriched antimicrobial peptide 2

increases expression

Clozapine results in increased expression of LEAP2 mRNA

NCBI chr10:37,580,172...37,581,244
Ensembl chr10:37,577,855...37,581,244

G

LEM domain nuclear envelope protein 2

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of LEMD2 protein

NCBI chr20:5,282,397...5,296,621
Ensembl chr20:5,282,397...5,296,626

G

leptin

affects response to substance
increases expression

LEP protein affects the susceptibility to Clozapine
Clozapine results in increased expression of LEP protein

PMID:16402076 PMID:17502770

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

galectin 8

increases expression

Clozapine results in increased expression of LGALS8 protein

NCBI chr17:58,024,652...58,052,764
Ensembl chr17:58,028,105...58,052,764

G

lipase A, lysosomal acid type

increases expression

Clozapine results in increased expression of LIPA protein

NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633

G

leiomodin 2

increases expression

Clozapine results in increased expression of LMOD2 protein

NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120

G

lipoprotein lipase

decreases expression
increases expression

Clozapine results in decreased expression of LPL mRNA; Clozapine results in decreased expression of LPL protein
Clozapine results in increased expression of LPL mRNA

PMID:17266109 PMID:19682446

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

LDL receptor related protein 10

increases expression

Clozapine results in increased expression of LRP10 protein

NCBI chr15:27,921,335...27,927,507
Ensembl chr15:27,920,259...27,927,505

G

leucine-rich pentatricopeptide repeat containing

increases expression

Clozapine results in increased expression of LRPPRC protein

NCBI chr 6:9,859,816...9,942,294
Ensembl chr 6:9,859,867...9,942,293

G

leucine-rich repeat kinase 2

increases expression

Clozapine results in increased expression of LRRK2 protein

NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703

G

lanosterol synthase

increases expression
multiple interactions

Clozapine results in increased expression of LSS mRNA
[Cuprizone co-treated with Clozapine] results in decreased expression of LSS protein

PMID:15342952 PMID:17175557 PMID:34122009

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

leukotriene A4 hydrolase

decreases expression

Clozapine results in decreased expression of LTA4H protein

NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600

G

magnesium transporter 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of MAGT1 protein

NCBI chr X:71,038,489...71,079,704
Ensembl chr X:71,038,489...71,079,699

G

mal, T-cell differentiation protein

decreases expression

Clozapine results in decreased expression of MAL mRNA

PMID:17266109 PMID:18797397

NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136

G

monoamine oxidase B

increases expression

Clozapine results in increased expression of MAOB mRNA

NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003

G

microtubule-associated protein 1A

increases expression
decreases expression

Clozapine results in increased expression of MAP1A mRNA
Clozapine results in decreased expr