CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: chlorpromazine
Accession: CHEBI:3647
browse the term
Definition: A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Synonyms: exact_synonym: 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine
related_synonym: 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine; 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine; Aminazine; CPZ; Chlorderazin; Chloropromazine; Chlorpromados; Contomin; Formula=C17H19ClN2S; InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3; InChIKey=ZPEIMTDSQAKGNT-UHFFFAOYSA-N; Largactil; N-(3-dimethylaminopropyl)-3-chlorophenothiazine; SMILES=CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12; Thorazine; chlorpromazinum; clorpromazina
xref: Beilstein:289793; CAS:50-53-3; DrugBank:DB00477; Drug_Central:621; HMDB:HMDB0014620; KEGG:C06906; KEGG:D00270; LINCS:LSM-4017
xref_mesh: MESH:D002746
xref: PDBeChem:Z80; PMID:14354584; PMID:14404586; PMID:15170372; PMID:1650428; PMID:16653219; PMID:20825390; PMID:2427628; PMID:7192992; Patent:US2645640; Reaxys:289793; Wikipedia:Chlorpromazine
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Abcb11
ATP binding cassette subfamily B member 11
multiple interactions decreases expression
ISO EXP
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCB11 mRNA Chlorpromazine results in decreased expression of ABCB11 mRNA
CTD
PMID:27344345 PMID:27765674 PMID:28391356
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
increases expression decreases activity
ISO
Chlorpromazine analog results in increased expression of ABCB1 mRNA Chlorpromazine results in decreased activity of ABCB1 protein
CTD
PMID:15924885 PMID:16810505
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b
ATP-binding cassette, subfamily B (MDR/TAP), member 1B
affects activity
EXP
Chlorpromazine affects the activity of ABCB1B protein
CTD
PMID:12626638
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Abcb4
ATP binding cassette subfamily B member 4
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCB4 mRNA
CTD
PMID:27344345
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcb6
ATP binding cassette subfamily B member 6
decreases expression
EXP
Chlorpromazine results in decreased expression of ABCB6 mRNA
CTD
PMID:25596134
NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
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Abcb9
ATP binding cassette subfamily B member 9
increases expression
EXP
Chlorpromazine results in increased expression of ABCB9 mRNA
CTD
PMID:25596134
NCBI chr12:32,499,225...32,531,932
Ensembl chr12:32,499,225...32,531,931
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Abcc2
ATP binding cassette subfamily C member 2
increases expression
EXP
Chlorpromazine results in increased expression of ABCC2 mRNA
CTD
PMID:27765674
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3
ATP binding cassette subfamily C member 3
increases expression decreases expression
ISO EXP
Chlorpromazine analog results in increased expression of ABCC3 mRNA Chlorpromazine results in decreased expression of ABCC3 mRNA
CTD
PMID:15924885 PMID:25596134
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcg2
ATP binding cassette subfamily G member 2
multiple interactions
ISO
Chlorpromazine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]
CTD
PMID:18834354
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Abcg8
ATP binding cassette subfamily G member 8
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCG8 mRNA
CTD
PMID:27344345
NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
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Acaca
acetyl-CoA carboxylase alpha
decreases phosphorylation
EXP
Chlorpromazine results in decreased phosphorylation of ACACA protein
CTD
PMID:17512020
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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Ace2
angiotensin I converting enzyme 2
decreases expression
ISO
Chlorpromazine results in decreased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Ache
acetylcholinesterase
decreases activity increases activity multiple interactions
ISO
Chlorpromazine results in decreased activity of ACHE protein Chlorpromazine results in increased activity of ACHE protein Dichlorvos promotes the reaction [Chlorpromazine results in decreased activity of ACHE protein]
CTD
PMID:4859365 PMID:29614332
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Acp5
acid phosphatase 5, tartrate resistant
multiple interactions
ISO
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]
CTD
PMID:21869564
NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
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Adra1a
adrenoceptor alpha 1A
decreases activity
EXP
Chlorpromazine results in decreased activity of ADRA1A protein
CTD
PMID:23611293
NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
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Adra1b
adrenoceptor alpha 1B
decreases activity
EXP
Chlorpromazine results in decreased activity of ADRA1B protein
CTD
PMID:23611293
NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
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Afp
alpha-fetoprotein
decreases expression
ISO
Chlorpromazine analog results in decreased expression of AFP mRNA
CTD
PMID:15924885
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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Agrn
agrin
decreases expression
EXP
Chlorpromazine results in decreased expression of AGRN mRNA
CTD
PMID:25596134
NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003
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Ahr
aryl hydrocarbon receptor
affects activity
EXP
Chlorpromazine affects the activity of AHR protein
CTD
PMID:25596134
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Ak3
adenylate kinase 3
decreases expression
EXP
Chlorpromazine results in decreased expression of AK3 mRNA
CTD
PMID:25596134
NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
EXP
Chlorpromazine results in decreased phosphorylation of AKT1 protein
CTD
PMID:17512020
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ALDH1A1 mRNA
CTD
PMID:27344345
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Aldoa
aldolase, fructose-bisphosphate A
increases expression
EXP
Chlorpromazine results in increased expression of ALDOA mRNA
CTD
PMID:25596134
NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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Alpp
alkaline phosphatase, placental
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Chlorpromazine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]
CTD
PMID:16036225
NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606
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Ap1s1
adaptor related protein complex 1 subunit sigma 1
decreases expression
ISO
Chlorpromazine results in decreased expression of AP1S1 mRNA
CTD
PMID:17175557
NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
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Apoc4
apolipoprotein C4
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of APOC4 mRNA
CTD
PMID:27344345
NCBI chr 1:79,335,745...79,339,942
Ensembl chr 1:79,335,745...79,339,981
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Apof
apolipoprotein F
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of APOF mRNA
CTD
PMID:27344345
NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946
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Areg
amphiregulin
decreases expression
ISO
Chlorpromazine results in decreased expression of AREG mRNA
CTD
PMID:15924885 PMID:30703373
NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
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Arfgef2
ADP ribosylation factor guanine nucleotide exchange factor 2
increases expression
EXP
Chlorpromazine results in increased expression of ARFGEF2 mRNA
CTD
PMID:25596134
NCBI chr 3:155,547,504...155,633,652
Ensembl chr 3:155,547,538...155,630,856
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Arhgef10
Rho guanine nucleotide exchange factor 10
decreases expression
EXP
Chlorpromazine results in decreased expression of ARHGEF10 mRNA
CTD
PMID:25596134
NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173
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Asah1
N-acylsphingosine amidohydrolase 1
increases expression
ISO
Chlorpromazine results in increased expression of ASAH1 mRNA
CTD
PMID:17175557
NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
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Asns
asparagine synthetase (glutamine-hydrolyzing)
increases expression
ISO
Chlorpromazine results in increased expression of ASNS mRNA
CTD
PMID:17175557
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Atf4
activating transcription factor 4
affects activity multiple interactions
EXP ISO
Chlorpromazine affects the activity of ATF4 protein [Chlorpromazine co-treated with Cholic Acids] affects the expression of ATF4 mRNA
CTD
PMID:25596134 PMID:27344345
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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Atp6v1b2
ATPase H+ transporting V1 subunit B2
decreases expression
EXP
Chlorpromazine results in decreased expression of ATP6V1B2 protein
CTD
PMID:19441803
NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745
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Avp
arginine vasopressin
increases expression multiple interactions
ISO EXP
Chlorpromazine results in increased expression of AVP protein Chlorpromazine inhibits the reaction [Lithium results in increased expression of AVP protein]
CTD
PMID:3567260 PMID:3976404
NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
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Bag4
BAG cochaperone 4
decreases expression
ISO
Chlorpromazine analog results in decreased expression of BAG4 mRNA
CTD
PMID:15924885
NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663
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Bcl2l1
Bcl2-like 1
increases expression
ISO
Chlorpromazine results in increased expression of BCL2L1 mRNA
CTD
PMID:21683644
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bdnf
brain-derived neurotrophic factor
affects response to substance affects expression
ISO EXP
BDNF affects the susceptibility to Chlorpromazine Chlorpromazine affects the expression of BDNF mRNA
CTD
PMID:18408624 PMID:31324950
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Bhlhe40
basic helix-loop-helix family, member e40
increases expression
ISO
Chlorpromazine analog results in increased expression of BHLHE40 mRNA
CTD
PMID:15924885
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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Birc2
baculoviral IAP repeat-containing 2
decreases expression
ISO
Chlorpromazine results in decreased expression of BIRC2 mRNA
CTD
PMID:30703373
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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Birc5
baculoviral IAP repeat-containing 5
decreases expression
ISO
Chlorpromazine analog results in decreased expression of BIRC5 mRNA; Chlorpromazine results in decreased expression of BIRC5 mRNA
CTD
PMID:15924885 PMID:30703373
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Bnip3
BCL2 interacting protein 3
increases expression
EXP
Chlorpromazine results in increased expression of BNIP3 mRNA
CTD
PMID:25596134
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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Btg2
BTG anti-proliferation factor 2
increases expression
ISO
Chlorpromazine analog results in increased expression of BTG2 mRNA
CTD
PMID:15924885
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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Btg3
BTG anti-proliferation factor 3
increases expression
ISO
Chlorpromazine analog results in increased expression of BTG3 mRNA
CTD
PMID:15924885
NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170
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C3
complement C3
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of C3 mRNA
CTD
PMID:27344345
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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C6
complement C6
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of C6 mRNA
CTD
PMID:27344345
NCBI chr 2:53,846,027...53,921,279
Ensembl chr 2:53,851,985...53,921,275
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Calcr
calcitonin receptor
multiple interactions
ISO
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]
CTD
PMID:21869564
NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392
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Calr
calreticulin
decreases expression
EXP
Chlorpromazine results in decreased expression of CALR mRNA
CTD
PMID:18246545
NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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Car2
carbonic anhydrase 2
multiple interactions
ISO
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]
CTD
PMID:21869564
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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Cat
catalase
multiple interactions decreases expression decreases activity
EXP ISO
carvedilol inhibits the reaction [Chlorpromazine results in decreased expression of CAT protein]; zolpidem inhibits the reaction [Chlorpromazine results in decreased activity of CAT]
CTD
PMID:12010767 PMID:17513028 PMID:25449126
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccn2
cellular communication network factor 2
decreases expression
ISO
Chlorpromazine results in decreased expression of CCN2 mRNA; Chlorpromazine results in decreased expression of CCN2 protein
CTD
PMID:30703373
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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Ccn3
cellular communication network factor 3
affects expression
EXP
Chlorpromazine affects the expression of CCN3 mRNA
CTD
PMID:31324950
NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019
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Ccnb2
cyclin B2
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CCNB2 mRNA; Chlorpromazine results in decreased expression of CCNB2 mRNA
CTD
PMID:15924885
NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
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Ccnd1
cyclin D1
decreases expression
EXP
Chlorpromazine results in decreased expression of CCND1 mRNA
CTD
PMID:17202759
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccnd3
cyclin D3
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CCND3 mRNA
CTD
PMID:15924885
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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Ccnf
cyclin F
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CCNF mRNA
CTD
PMID:15924885
NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
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Cd274
CD274 molecule
multiple interactions
ISO
Chlorpromazine inhibits the reaction [platycodin D results in decreased expression of and results in increased secretion of CD274 protein]
CTD
PMID:31150782
NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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Cd44
CD44 molecule (Indian blood group)
multiple interactions decreases expression
ISO
Chlorpromazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD44 protein] Chlorpromazine results in decreased expression of CD44 protein
CTD
PMID:9929743 PMID:30703373
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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Cd86
CD86 molecule
increases expression
ISO
Chlorpromazine results in increased expression of CD86 protein
CTD
PMID:19665512
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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Cdk5
cyclin-dependent kinase 5
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CDK5 mRNA
CTD
PMID:15924885
NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
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Cdk7
cyclin-dependent kinase 7
increases expression
ISO
Chlorpromazine analog results in increased expression of CDK7 mRNA
CTD
PMID:15924885
NCBI chr 2:31,840,545...31,865,447
Ensembl chr 2:31,840,558...31,865,383
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions increases expression
EXP
[EGR1 binds to CDKN1A promoter] promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; EGR1 promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]
CTD
PMID:20368687
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn2c
cyclin-dependent kinase inhibitor 2C
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CDKN2C mRNA
CTD
PMID:15924885
NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
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Ces2h
carboxylesterase 2H
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of CES2 mRNA
CTD
PMID:27344345
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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Cfh
complement factor H
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of CFH mRNA
CTD
PMID:27344345
NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
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Cgref1
cell growth regulator with EF hand domain 1
decreases expression
EXP
Chlorpromazine results in decreased expression of CGREF1 mRNA
CTD
PMID:17202759
NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852
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Chtf18
chromosome transmission fidelity factor 18
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CHTF18 mRNA
CTD
PMID:15924885
NCBI chr10:14,743,006...14,751,044
Ensembl chr10:14,742,621...14,751,050
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Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
decreases expression
EXP
Chlorpromazine results in decreased expression of CITED2 mRNA
CTD
PMID:18246545
NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
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Cks2
CDC28 protein kinase regulatory subunit 2
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CKS2 mRNA
CTD
PMID:15924885
NCBI chr17:13,570,611...13,575,770
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Clcf1
cardiotrophin-like cytokine factor 1
increases expression
ISO
Chlorpromazine results in increased expression of CLCF1 mRNA
CTD
PMID:21683644
NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605
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Col18a1
collagen type XVIII alpha 1 chain
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of COL18A1 mRNA
CTD
PMID:27344345
NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
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Col4a1
collagen type IV alpha 1 chain
decreases expression
EXP
Chlorpromazine results in decreased expression of COL4A1 mRNA
CTD
PMID:25596134
NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
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Cort
cortistatin
affects expression
EXP
Chlorpromazine affects the expression of CORT mRNA
CTD
PMID:31324950
NCBI chr 5:159,560,591...159,562,032
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Cox8a
cytochrome c oxidase subunit 8A
affects expression increases expression
EXP
Chlorpromazine affects the expression of COX8A mRNA Chlorpromazine results in increased expression of COX8A mRNA
CTD
PMID:18246545
NCBI chr 1:204,402,118...204,404,439
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Crh
corticotropin releasing hormone
decreases expression
ISO
Chlorpromazine results in decreased expression of CRH mRNA
CTD
PMID:16205782
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Cth
cystathionine gamma-lyase
decreases expression
EXP
Chlorpromazine results in decreased expression of CTH mRNA
CTD
PMID:25596134
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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Ctsk
cathepsin K
multiple interactions
ISO
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]
CTD
PMID:21869564
NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions decreases activity decreases response to substance increases expression
ISO EXP
[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] Chlorpromazine results in decreased activity of CYP1A1 protein CYP1A1 protein results in decreased susceptibility to Chlorpromazine Chlorpromazine results in increased expression of CYP1A1 mRNA
CTD
PMID:17202759 PMID:18246545 PMID:18493746 PMID:25596134 PMID:26477383 PMID:29724254 PMID:33814510 More...
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions decreases response to substance increases expression increases oxidation affects expression decreases methylation
ISO EXP
[Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP1A2 mRNA; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; CYP1A2 protein results in increased metabolism of and results in increased activity of Chlorpromazine CYP1A2 protein results in decreased susceptibility to Chlorpromazine Chlorpromazine results in increased expression of CYP1A2 mRNA CYP1A2 protein results in increased oxidation of Chlorpromazine Chlorpromazine affects the expression of CYP1A2 mRNA CYP1A2 protein results in decreased methylation of Chlorpromazine
CTD
PMID:18246545 PMID:18493746 PMID:19482014 PMID:20615392 PMID:23397584 PMID:25596134 PMID:26477383 PMID:27344345 More...
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases response to substance decreases activity multiple interactions
ISO
CYP1B1 protein results in decreased susceptibility to Chlorpromazine Chlorpromazine results in decreased activity of CYP1B1 protein [Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA]
CTD
PMID:26477383 PMID:29724254 PMID:33814510
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
multiple interactions
ISO
NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP2B10 mRNA]
CTD
PMID:12049174
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions decreases response to substance
ISO
[Chlorpromazine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Chlorpromazine inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]] CYP2B6 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:10037683 PMID:17041008 PMID:26477383
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
decreases expression
EXP
Chlorpromazine results in decreased expression of CYP2C mRNA; Chlorpromazine results in decreased expression of CYP2C11 mRNA
CTD
PMID:18246545
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2c24
cytochrome P450, family 2, subfamily c, polypeptide 24
decreases response to substance
ISO
CYP2C18 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:26477383
NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
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Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
multiple interactions decreases response to substance decreases activity affects methylation
ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine CYP2C19 protein results in decreased susceptibility to Chlorpromazine Chlorpromazine results in decreased activity of CYP2C19 protein CYP2C19 protein affects the methylation of Chlorpromazine
CTD
PMID:15135088 PMID:20615392 PMID:23397584 PMID:26477383
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
decreases response to substance
ISO
CYP2C8 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:26477383
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
multiple interactions decreases response to substance
ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; CYP2D6 protein results in increased metabolism of and results in increased activity of Chlorpromazine CYP2D6 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:19482014 PMID:23397584 PMID:26477383
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases activity decreases response to substance
ISO
Chlorpromazine results in decreased activity of CYP2E1 protein CYP2E1 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:15135088 PMID:26477383
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
affects methylation affects oxidation multiple interactions decreases response to substance decreases activity
ISO
CYP3A4 protein affects the methylation of Chlorpromazine CYP3A4 protein affects the oxidation of Chlorpromazine [Chlorpromazine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine CYP3A4 protein results in decreased susceptibility to Chlorpromazine Chlorpromazine results in decreased activity of CYP3A4 protein
CTD
PMID:15135088 PMID:17041008 PMID:20615392 PMID:23397584 PMID:26477383
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
decreases response to substance
ISO
CYP3A5 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:26477383
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Cyp8b1
cytochrome P450 family 8 subfamily B member 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP8B1 mRNA
CTD
PMID:27344345
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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Dao
D-amino-acid oxidase
decreases activity
ISO
Chlorpromazine results in decreased activity of DAO protein
CTD
PMID:18615285
NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741
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Dcstamp
dendrocyte expressed seven transmembrane protein
multiple interactions
ISO
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]
CTD
PMID:21869564
NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078
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Ddit3
DNA-damage inducible transcript 3
increases expression
EXP
Chlorpromazine results in increased expression of DDIT3 mRNA
CTD
PMID:25596134
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Depp1
DEPP1, autophagy regulator
increases expression
ISO
Chlorpromazine results in increased expression of DEPP1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
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Drd1
dopamine receptor D1
decreases activity
ISO
Chlorpromazine results in decreased activity of DRD1 protein
CTD
PMID:23611293
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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Drd2
dopamine receptor D2
decreases response to substance decreases activity
ISO
DRD2 polymorphism results in decreased susceptibility to Chlorpromazine Chlorpromazine results in decreased activity of DRD2 protein
CTD
PMID:15694263 PMID:23611293
NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
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Dusp1
dual specificity phosphatase 1
increases expression affects expression
ISO
Chlorpromazine analog results in increased expression of DUSP1 mRNA Chlorpromazine affects the expression of DUSP1 mRNA
CTD
PMID:15924885 PMID:20843724
NCBI chr10:16,680,489...16,683,276
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Dusp9
dual specificity phosphatase 9
decreases expression
ISO
Chlorpromazine analog results in decreased expression of DUSP9 mRNA
CTD
PMID:15924885
NCBI chr X:151,351,897...151,355,822
Ensembl chr X:151,351,897...151,355,821
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E2f1
E2F transcription factor 1
decreases expression
ISO
Chlorpromazine analog results in decreased expression of E2F1 mRNA
CTD
PMID:15924885
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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Egr1
early growth response 1
increases expression multiple interactions
EXP
Chlorpromazine results in increased expression of EGR1 [EGR1 binds to CDKN1A promoter] promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; EGR1 promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; MAPK1 affects the reaction [Chlorpromazine results in increased expression of EGR1]; MAPK3 affects the reaction [Chlorpromazine results in increased expression of EGR1]
CTD
PMID:20368687
NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
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Eif1
eukaryotic translation initiation factor 1
increases expression
EXP
Chlorpromazine results in increased expression of EIF1 mRNA
CTD
PMID:25596134
NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
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Eno2
enolase 2
increases expression
EXP
Chlorpromazine results in increased expression of ENO2 mRNA
CTD
PMID:25596134
NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
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Ero1a
endoplasmic reticulum oxidoreductase 1 alpha
increases expression
EXP
Chlorpromazine results in increased expression of ERO1A mRNA
CTD
PMID:25596134
NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
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F2
coagulation factor II
decreases expression
ISO
Chlorpromazine analog results in decreased expression of F2 mRNA
CTD
PMID:15924885
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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Fabp1
fatty acid binding protein 1
increases expression
ISO
Chlorpromazine results in increased expression of FABP1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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Fas
Fas cell surface death receptor
increases expression
ISO
Chlorpromazine analog results in increased expression of FAS mRNA
CTD
PMID:15924885
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fbp1
fructose-bisphosphatase 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of FBP1 mRNA
CTD
PMID:27344345
NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
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Fbxo22
F-box protein 22
decreases expression
EXP
Chlorpromazine results in decreased expression of FBXO22 mRNA
CTD
PMID:25596134
NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148
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Fech
ferrochelatase
decreases expression
EXP
Chlorpromazine results in decreased expression of FECH mRNA
CTD
PMID:25596134
NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
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Fetub
fetuin B
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of FETUB mRNA
CTD
PMID:27344345
NCBI chr11:78,082,158...78,093,022
Ensembl chr11:78,082,156...78,095,135
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Fga
fibrinogen alpha chain
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of FGA mRNA
CTD
PMID:27344345
NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528
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Fgf2
fibroblast growth factor 2
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of FGF2 mRNA
CTD
PMID:27344345
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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Fgfr1
Fibroblast growth factor receptor 1
decreases expression
ISO
Chlorpromazine analog results in decreased expression of FGFR1 mRNA
CTD
PMID:15924885
NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350
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Fgr
FGR proto-oncogene, Src family tyrosine kinase
decreases expression
EXP
Chlorpromazine results in decreased expression of FGR mRNA
CTD
PMID:25596134
NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
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Fkbp5
FKBP prolyl isomerase 5
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Lipopolysaccharides results in decreased expression of FKBP5 protein]
CTD
PMID:21034739
NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
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Fndc4
fibronectin type III domain containing 4
increases expression
ISO
Chlorpromazine results in increased expression of FNDC4 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
affects expression
ISO
Chlorpromazine affects the expression of FOS mRNA
CTD
PMID:20843724
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Fosb
FosB proto-oncogene, AP-1 transcription factor subunit
affects expression
ISO
Chlorpromazine affects the expression of FOSB mRNA
CTD
PMID:20843724
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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Fosl1
FOS like 1, AP-1 transcription factor subunit
increases expression affects expression
ISO
Chlorpromazine analog results in increased expression of FOSL1 mRNA Chlorpromazine affects the expression of FOSL1 mRNA
CTD
PMID:15924885 PMID:20843724
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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Fosl2
FOS like 2, AP-1 transcription factor subunit
affects expression
ISO
Chlorpromazine affects the expression of FOSL2 mRNA
CTD
PMID:20843724
NCBI chr 6:24,297,898...24,319,157
Ensembl chr 6:24,300,956...24,320,034
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Fth1
ferritin heavy chain 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of FTH1 mRNA
CTD
PMID:27344345
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G6pd
glucose-6-phosphate dehydrogenase
decreases expression decreases activity multiple interactions
ISO EXP
Chlorpromazine analog results in decreased expression of G6PD mRNA Chlorpromazine results in decreased activity of G6PD protein [Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; Taurine inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]
CTD
PMID:15924885 PMID:33548410
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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Gad1
glutamate decarboxylase 1
decreases methylation multiple interactions
ISO
Chlorpromazine results in decreased methylation of GAD1 promoter Valproic Acid promotes the reaction [Chlorpromazine results in decreased methylation of GAD1 promoter]
CTD
PMID:19110320
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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Gcgr
glucagon receptor
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of GCGR mRNA
CTD
PMID:27344345
NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640
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Gclc
glutamate-cysteine ligase, catalytic subunit
decreases expression
EXP
Chlorpromazine results in decreased expression of GCLC mRNA
CTD
PMID:25596134
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gdf15
growth differentiation factor 15
increases expression
EXP
Chlorpromazine results in increased expression of GDF15 mRNA
CTD
PMID:25596134
NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
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Gdpd3
glycerophosphodiester phosphodiesterase domain containing 3
increases expression
ISO
Chlorpromazine results in increased expression of GDPD3 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
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Gfap
glial fibrillary acidic protein
affects expression
EXP
Chlorpromazine affects the expression of GFAP mRNA
CTD
PMID:31324950
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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Gpnmb
glycoprotein nmb
increases expression
EXP
Chlorpromazine results in increased expression of GPNMB mRNA
CTD
PMID:25596134
NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
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Gsr
glutathione-disulfide reductase
decreases activity
EXP
Chlorpromazine results in decreased activity of GSR protein
CTD
PMID:6693892
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Gsta1
glutathione S-transferase alpha 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of GSTA1 mRNA
CTD
PMID:27344345
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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Hif1a
hypoxia inducible factor 1 subunit alpha
affects activity
EXP
Chlorpromazine affects the activity of HIF1A protein
CTD
PMID:25596134
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
increases expression
ISO
Chlorpromazine results in increased expression of HMGCR mRNA
CTD
PMID:17052361
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
increases expression
ISO
Chlorpromazine results in increased expression of HMGCS1 mRNA
CTD
PMID:17052361
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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Hmox1
heme oxygenase 1
increases expression affects expression
ISO EXP
Chlorpromazine results in increased expression of HMOX1 mRNA Chlorpromazine affects the expression of HMOX1 mRNA
CTD
PMID:15924885 PMID:25596134 PMID:31324950
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hpn
hepsin
increases expression
ISO
Chlorpromazine results in increased expression of HPN mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
G
Ibsp
integrin-binding sialoprotein
decreases expression multiple interactions
EXP
Chlorpromazine results in decreased expression of IBSP mRNA herbimycin inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA]; U 0126 inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA]
CTD
PMID:16294319
NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693
G
Ifnb1
interferon beta 1
multiple interactions
ISO
Chlorpromazine promotes the reaction [PAM2-CSK4 results in increased expression of IFNB1 mRNA]
CTD
PMID:32796029
NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
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Ifng
interferon gamma
multiple interactions
ISO
[Chlorpromazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
CTD
PMID:29594315
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Ifnlr1
interferon, lambda receptor 1
increases expression
ISO
Chlorpromazine results in increased expression of IFNLR1 mRNA
CTD
PMID:21683644
NCBI chr 5:147,919,547...147,942,328
Ensembl chr 5:147,919,908...147,942,332
G
Igfbp1
insulin-like growth factor binding protein 1
increases expression
ISO
Chlorpromazine results in increased expression of IGFBP1 mRNA
CTD
PMID:15924885
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
increases expression
ISO
Chlorpromazine analog results in increased expression of IKBKG mRNA
CTD
PMID:15924885
NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499
G
Il1a
interleukin 1 alpha
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine
CTD
PMID:19362101
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il1b
interleukin 1 beta
decreases expression
ISO
Chlorpromazine results in decreased expression of IL1B mRNA
CTD
PMID:29594315
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il2
interleukin 2
multiple interactions
ISO
[Chlorpromazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]; Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]
CTD
PMID:11014349 PMID:29594315
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Il6
interleukin 6
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine
CTD
PMID:19362101
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Inhbe
inhibin subunit beta E
increases expression
ISO
Chlorpromazine results in increased expression of INHBE mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 7:63,177,558...63,178,983
Ensembl chr 7:63,176,219...63,179,172
G
Insig2
insulin induced gene 2
decreases expression
EXP
Chlorpromazine results in decreased expression of INSIG2 mRNA
CTD
PMID:25596134
NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
G
Irs2
insulin receptor substrate 2
multiple interactions
EXP
Chlorpromazine results in decreased expression of and results in decreased phosphorylation of IRS2 protein; Chlorpromazine results in decreased expression of and results in increased degradation of IRS2 protein
CTD
PMID:17512020 PMID:18308779
NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions decreases activity
ISO
Chlorpromazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Chlorpromazine results in decreased activity of KCNH2 protein
CTD
PMID:15071359 PMID:21158687 PMID:24052561
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Kcnn2
potassium calcium-activated channel subfamily N member 2
decreases activity
EXP
Chlorpromazine results in decreased activity of KCNN2 protein
CTD
PMID:10915830
NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
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Klf4
Kruppel like factor 4
multiple interactions decreases expression
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of KLF4 mRNA Chlorpromazine results in decreased expression of KLF4 mRNA
CTD
PMID:27344345 PMID:30703373
NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
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Klkb1
kallikrein B1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of KLKB1 mRNA
CTD
PMID:27344345
NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
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Kng2
kininogen 2
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of KNG1 mRNA
CTD
PMID:27344345
NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
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Lats1
large tumor suppressor kinase 1
increases phosphorylation
ISO
Chlorpromazine results in increased phosphorylation of LATS1 protein
CTD
PMID:30703373
NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640
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Ldhc
lactate dehydrogenase C
decreases activity multiple interactions
EXP
Chlorpromazine results in decreased activity of LDHC protein [Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; Taurine inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]
CTD
PMID:33548410
NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378
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Ldlr
low density lipoprotein receptor
increases expression
ISO
Chlorpromazine results in increased expression of LDLR mRNA
CTD
PMID:17052361
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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Lep
leptin
increases expression
EXP
Chlorpromazine results in increased expression of LEP protein
CTD
PMID:17512020
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lss
lanosterol synthase
increases expression
ISO
Chlorpromazine results in increased expression of LSS mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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Map2
microtubule-associated protein 2
increases expression
EXP
Chlorpromazine results in increased expression of MAP2 mRNA
CTD
PMID:15079866
NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO EXP
Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein] MAPK1 affects the reaction [Chlorpromazine results in increased expression of EGR1]
CTD
PMID:11014349 PMID:20368687
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk14
mitogen activated protein kinase 14
decreases expression
ISO
Chlorpromazine analog results in decreased expression of MAPK14 mRNA
CTD
PMID:15924885
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mapk3
mitogen activated protein kinase 3
decreases expression multiple interactions
ISO EXP
Chlorpromazine analog results in decreased expression of MAPK3 mRNA MAPK3 affects the reaction [Chlorpromazine results in increased expression of EGR1] Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]
CTD
PMID:11014349 PMID:15924885 PMID:20368687
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein; Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]]
CTD
PMID:23238562
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mapkapk2
MAPK activated protein kinase 2
increases expression
EXP
Chlorpromazine results in increased expression of MAPKAPK2 mRNA
CTD
PMID:19441803
NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
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Mcm3
minichromosome maintenance complex component 3
decreases expression
ISO
Chlorpromazine analog results in decreased expression of MCM3 mRNA
CTD
PMID:15924885
NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
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Mcm5
minichromosome maintenance complex component 5
decreases expression
ISO
Chlorpromazine analog results in decreased expression of MCM5 mRNA
CTD
PMID:15924885
NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389
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Mdm2
MDM2 proto-oncogene
increases expression
EXP
Chlorpromazine results in increased expression of MDM2 mRNA
CTD
PMID:25596134
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Mitf
melanocyte inducing transcription factor
increases expression
ISO
Chlorpromazine results in increased expression of MITF protein
CTD
PMID:25449126
NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
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Mki67
marker of proliferation Ki-67
decreases expression
ISO
Chlorpromazine analog results in decreased expression of MKI67 mRNA
CTD
PMID:15924885
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
Chlorpromazine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]; Chlorpromazine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein]
CTD
PMID:25200491
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Msc
musculin
decreases expression
EXP
Chlorpromazine results in decreased expression of MSC mRNA
CTD
PMID:25596134
NCBI chr 5:4,547,335...4,553,206
Ensembl chr 5:4,547,405...4,553,203
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Msh2
mutS homolog 2
decreases expression
ISO
Chlorpromazine results in decreased expression of MSH2 mRNA
CTD
PMID:15924885
NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
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Mst1
macrophage stimulating 1
increases phosphorylation
ISO
Chlorpromazine results in increased phosphorylation of MST1 protein
CTD
PMID:30703373
NCBI chr 8:108,767,886...108,773,425
Ensembl chr 8:108,768,839...108,773,416
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Mt1
metallothionein 1
increases expression
EXP
Chlorpromazine results in increased expression of MT1A mRNA
CTD
PMID:8128501
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
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Mybl2
MYB proto-oncogene like 2
decreases expression
ISO
Chlorpromazine analog results in decreased expression of MYBL2 mRNA
CTD
PMID:15924885
NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression
ISO
Chlorpromazine results in decreased expression of MYC mRNA
CTD
PMID:30703373
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Nampt
nicotinamide phosphoribosyltransferase
increases expression
EXP
Chlorpromazine results in increased expression of NAMPT mRNA
CTD
PMID:25596134
NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
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Nanog
Nanog homeobox
decreases expression
ISO
Chlorpromazine results in decreased expression of NANOG mRNA
CTD
PMID:30703373
NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
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Ndufs3
NADH:ubiquinone oxidoreductase core subunit S3
decreases expression
EXP
Chlorpromazine results in decreased expression of NDUFS3 protein
CTD
PMID:19441803
NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824
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Nectin2
nectin cell adhesion molecule 2
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Cadmium Chloride results in decreased expression of and affects the localization of NECTIN2 protein]
CTD
PMID:25046863
NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360
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Nedd9
neural precursor cell expressed, developmentally down-regulated 9
decreases expression
EXP
Chlorpromazine results in decreased expression of NEDD9 mRNA
CTD
PMID:25596134
NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
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Nefh
neurofilament heavy chain
affects expression
EXP
Chlorpromazine affects the expression of NEFH mRNA
CTD
PMID:31324950
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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Nfatc1
nuclear factor of activated T-cells 1
multiple interactions
ISO
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]
CTD
PMID:21869564
NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
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Nfe2l2
NFE2 like bZIP transcription factor 2
decreases expression affects activity
EXP
Chlorpromazine results in decreased expression of NFE2L2 mRNA Chlorpromazine affects the activity of NFE2L2 protein
CTD
PMID:25596134
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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Ninj1
ninjurin 1
increases expression
EXP
Chlorpromazine results in increased expression of NINJ1 mRNA
CTD
PMID:25596134
NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Chlorpromazine results in increased expression of NR0B2 mRNA
CTD
PMID:17175557
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
decreases expression
EXP
Chlorpromazine results in decreased expression of NR1H4 mRNA
CTD
PMID:27765674 PMID:28391356
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases expression multiple interactions
ISO
Chlorpromazine analog results in increased expression of NR1I2 mRNA [Chlorpromazine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD
PMID:15924885 PMID:17041008
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity increases expression multiple interactions
ISO
Chlorpromazine results in increased activity of NR1I3 protein Chlorpromazine results in increased expression of NR1I3 mRNA [Chlorpromazine co-treated with Cholic Acids] affects the expression of NR1I3 mRNA; [Chlorpromazine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Chlorpromazine inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]] NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP2B10 mRNA]; NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP3A11 mRNA]
CTD
PMID:10037683 PMID:12049174 PMID:12948398 PMID:17041008 PMID:22310298 PMID:27344345 More...
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]
CTD
PMID:16581232
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nupr1
nuclear protein 1, transcriptional regulator
increases expression
ISO
Chlorpromazine results in increased expression of NUPR1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 1:181,213,292...181,215,327
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Orc1
origin recognition complex, subunit 1
decreases expression
ISO
Chlorpromazine analog results in decreased expression of ORC1 mRNA
CTD
PMID:15924885
NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375
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Orm1
orosomucoid 1
affects binding multiple interactions
ISO
Chlorpromazine binds to ORM1 protein alternative form Chlorpromazine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]
CTD
PMID:8946472
NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
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Pdia2
protein disulfide isomerase family A, member 2
increases expression
ISO
Chlorpromazine analog results in increased expression of PDIA2 mRNA
CTD
PMID:15924885
NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931
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Pdia5
protein disulfide isomerase family A, member 5
decreases expression
EXP
Chlorpromazine results in decreased expression of PDIA5 mRNA
CTD
PMID:25596134
NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084
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Pdk1
pyruvate dehydrogenase kinase 1
increases expression
EXP
Chlorpromazine results in increased expression of PDK1 mRNA
CTD
PMID:25596134
NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
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Pdk4
pyruvate dehydrogenase kinase 4
increases expression
EXP
Chlorpromazine results in increased expression of PDK4 mRNA
CTD
PMID:25596134
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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Phyh
phytanoyl-CoA 2-hydroxylase
increases expression
ISO
Chlorpromazine results in increased expression of PHYH mRNA
CTD
PMID:15342952
NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409
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Pias1
protein inhibitor of activated STAT, 1
increases expression
ISO
Chlorpromazine results in increased expression of PIAS1 mRNA
CTD
PMID:21683644
NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905
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Pim1
Pim-1 proto-oncogene, serine/threonine kinase
increases expression
ISO
Chlorpromazine analog results in increased expression of PIM1 mRNA
CTD
PMID:15924885
NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174
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Pir
pirin
decreases expression
EXP
Chlorpromazine results in decreased expression of PIR mRNA
CTD
PMID:25596134
NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218
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Plin2
perilipin 2
increases expression
EXP
Chlorpromazine results in increased expression of PLIN2 mRNA
CTD
PMID:25596134
NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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Pmepa1
prostate transmembrane protein, androgen induced 1
decreases expression
EXP
Chlorpromazine results in decreased expression of PMEPA1 mRNA
CTD
PMID:25596134
NCBI chr 3:162,011,884...162,060,137
Ensembl chr 3:162,012,751...162,060,454
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Pola1
DNA polymerase alpha 1, catalytic subunit
decreases expression
ISO
Chlorpromazine analog results in decreased expression of POLA1 mRNA
CTD
PMID:15924885
NCBI chr X:58,034,617...58,348,612
Ensembl chr X:58,034,619...58,348,536
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Pold4
DNA polymerase delta 4, accessory subunit
increases expression
ISO
Chlorpromazine analog results in increased expression of POLD4 mRNA
CTD
PMID:15924885
NCBI chr 1:201,526,591...201,528,406
Ensembl chr 1:201,526,665...201,528,401
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Pou5f1
POU class 5 homeobox 1
decreases expression
ISO
Chlorpromazine results in decreased expression of POU5F1 mRNA
CTD
PMID:30703373
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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Pparg
peroxisome proliferator-activated receptor gamma
affects activity
EXP
Chlorpromazine affects the activity of PPARG protein
CTD
PMID:25596134
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
increases expression
EXP
Chlorpromazine results in increased expression of PPP1R15A mRNA
CTD
PMID:25596134
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
decreases phosphorylation
EXP
Chlorpromazine results in decreased phosphorylation of PRKAA1 protein
CTD
PMID:17512020
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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Prl
prolactin
increases expression
ISO
Chlorpromazine results in increased expression of PRL protein
CTD
PMID:718334 PMID:996201
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Rara
retinoic acid receptor, alpha
decreases expression
EXP
Chlorpromazine results in decreased expression of RARA mRNA
CTD
PMID:18246545
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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Rnd1
Rho family GTPase 1
decreases expression
EXP
Chlorpromazine results in decreased expression of RND1 mRNA
CTD
PMID:25596134
NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
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Rnd3
Rho family GTPase 3
decreases expression
EXP
Chlorpromazine results in decreased expression of RND3 mRNA
CTD
PMID:25596134
NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327
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Rnf121
ring finger protein 121
decreases expression
EXP
Chlorpromazine results in decreased expression of RNF121 mRNA
CTD
PMID:25596134
NCBI chr 1:156,377,583...156,439,923
Ensembl chr 1:156,377,364...156,446,826
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Runx1
RUNX family transcription factor 1
increases expression
EXP
Chlorpromazine results in increased expression of RUNX1 mRNA
CTD
PMID:25596134
NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
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Rxrg
retinoid X receptor gamma
affects response to substance
ISO
RXRG protein affects the susceptibility to Chlorpromazine
CTD
PMID:10336693
NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167
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Sat1
spermidine/spermine N1-acetyl transferase 1
increases expression
EXP
Chlorpromazine results in increased expression of SAT1 mRNA
CTD
PMID:25596134
NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
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Sc5d
sterol-C5-desaturase
increases expression
ISO
Chlorpromazine results in increased expression of SC5D mRNA
CTD
PMID:17052361
NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
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Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
increases expression
ISO
Chlorpromazine results in increased expression of SERPINA3 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 6:123,323,632...123,331,166
Ensembl chr 6:123,323,629...123,332,433
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Sesn1
sestrin 1
decreases expression
EXP
Chlorpromazine results in decreased expression of SESN1 mRNA
CTD
PMID:25596134
NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
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Sik1
salt-inducible kinase 1
decreases expression
EXP
Chlorpromazine results in decreased expression of SIK1 mRNA
CTD
PMID:25596134
NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
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Slc10a1
solute carrier family 10 member 1
decreases expression
EXP
Chlorpromazine results in decreased expression of SLC10A1 mRNA
CTD
PMID:27765674 PMID:28391356
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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Slc12a8
solute carrier family 12, member 8
increases expression
EXP
Chlorpromazine results in increased expression of SLC12A8 mRNA
CTD
PMID:25596134
NCBI chr11:67,116,876...67,266,548
Ensembl chr11:67,116,877...67,266,834
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Slc19a1
solute carrier family 19 member 1
multiple interactions decreases activity
EXP
Chlorpromazine inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate] Chlorpromazine results in decreased activity of SLC19A1 protein
CTD
PMID:17482559
NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972
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Slc1a5
solute carrier family 1 member 5
increases expression
EXP
Chlorpromazine results in increased expression of SLC1A5 mRNA
CTD
PMID:25596134
NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Chlorpromazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc22a7
solute carrier family 22 member 7
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of SLC22A7 mRNA
CTD
PMID:27344345
NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
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Slc2a3
solute carrier family 2 member 3
decreases expression
ISO
Chlorpromazine results in decreased expression of SLC2A3 mRNA
CTD
PMID:15342952
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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Slc31a1
solute carrier family 31 member 1
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Copper affects the localization of SLC31A1 protein]
CTD
PMID:12501239
NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
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Slc3a2
solute carrier family 3 member 2
increases expression
EXP
Chlorpromazine results in increased expression of SLC3A2 mRNA
CTD
PMID:25596134
NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
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Slc51b
solute carrier family 51 subunit beta
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of SLC51B mRNA
CTD
PMID:27344345
NCBI chr 8:65,931,891...65,934,893
Ensembl chr 8:65,931,890...65,940,145
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Slc6a6
solute carrier family 6 member 6
increases expression
EXP
Chlorpromazine results in increased expression of SLC6A6 mRNA
CTD
PMID:25596134
NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
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Slco2b1
solute carrier organic anion transporter family, member 2b1
decreases expression
EXP
Chlorpromazine results in decreased expression of SLCO2B1 mRNA
CTD
PMID:25596134
NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
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Sod1
superoxide dismutase 1
multiple interactions
EXP
Chlorpromazine inhibits the reaction [Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]]
CTD
PMID:22362149
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sox2
SRY-box transcription factor 2
decreases expression
ISO
Chlorpromazine results in decreased expression of SOX2 mRNA
CTD
PMID:30703373
NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
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Spp1
secreted phosphoprotein 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of SPP1 mRNA
CTD
PMID:27344345
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Spsb1
splA/ryanodine receptor domain and SOCS box containing 1
increases expression
EXP
Chlorpromazine results in increased expression of SPSB1 mRNA
CTD
PMID:25596134
NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
multiple interactions
EXP
Chlorpromazine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased phosphorylation of SRC protein]
CTD
PMID:29702141
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Srebf2
sterol regulatory element binding transcription factor 2
multiple interactions
ISO
Chlorpromazine results in increased cleavage of and results in increased activity of SREBF2 protein
CTD
PMID:17052361
NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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Strbp
spermatid perinuclear RNA binding protein
increases expression
EXP
Chlorpromazine results in increased expression of STRBP mRNA
CTD
PMID:25596134
NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949
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Sts
steroid sulfatase
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Tretinoin results in increased activity of STS protein]
CTD
PMID:16178010
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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Tagln
transgelin
decreases expression
ISO
Chlorpromazine results in decreased expression of TAGLN mRNA
CTD
PMID:17175557
NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
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Tf
transferrin
affects localization
ISO
Chlorpromazine affects the localization of TF protein
CTD
PMID:12501239
NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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Tfdp1
transcription factor Dp-1
decreases expression
ISO
Chlorpromazine analog results in decreased expression of TFDP1 mRNA
CTD
PMID:15924885
NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817
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Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
increases expression
EXP
Chlorpromazine results in increased expression of TIPARP mRNA
CTD
PMID:25596134
NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327
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Tirap
TIR domain containing adaptor protein
multiple interactions
ISO
TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipoteichoic acid]
CTD
PMID:23238562
NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432
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Tnf
tumor necrosis factor
decreases expression increases response to substance multiple interactions
ISO
Chlorpromazine analog results in decreased expression of TNF protein; Chlorpromazine results in decreased expression of TNF mRNA TNF protein results in increased susceptibility to Chlorpromazine [Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein; [Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein; Chlorpromazine inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride]; Chlorpromazine inhibits the reaction [hydroquinone results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased susceptibility to Chlorpromazine]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein] [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine; Chlorpromazine results in decreased expression of and results in decreased activity of TNF protein
CTD
PMID:8550079 PMID:15052360 PMID:19362101 PMID:20371967 PMID:22414385 PMID:23238562 More...
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfaip8
TNF alpha induced protein 8
increases expression
EXP
Chlorpromazine results in increased expression of TNFAIP8 mRNA
CTD
PMID:25596134
NCBI chr18:43,183,854...43,299,517
Ensembl chr18:43,183,916...43,299,517
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Tnfrsf14
TNF receptor superfamily member 14
increases expression
ISO
Chlorpromazine analog results in increased expression of TNFRSF14 mRNA
CTD
PMID:15924885
NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703
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Tnfsf11
TNF superfamily member 11
decreases activity multiple interactions
ISO
Chlorpromazine results in decreased activity of TNFSF11; Chlorpromazine results in decreased activity of TNFSF11 protein Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]
CTD
PMID:21869564
NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
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Tp53
tumor protein p53
affects activity
EXP
Chlorpromazine affects the activity of TP53 protein
CTD
PMID:25596134
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Trafd1
TRAF type zinc finger domain containing 1
decreases expression
EXP
Chlorpromazine results in decreased expression of TRAFD1 mRNA
CTD
PMID:25596134
NCBI chr12:35,165,606...35,179,525
Ensembl chr12:35,165,606...35,179,525
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Tuba1a
tubulin, alpha 1A
decreases expression
ISO
Chlorpromazine results in decreased expression of TUBA1A mRNA
CTD
PMID:27015953
NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186
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Txn1
thioredoxin 1
decreases expression
EXP
Chlorpromazine results in decreased expression of TXN1 mRNA
CTD
PMID:25596134
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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Txnrd1
thioredoxin reductase 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of TXNRD1 mRNA
CTD
PMID:27344345
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Tyr
tyrosinase
increases expression
ISO
Chlorpromazine results in increased expression of TYR protein
CTD
PMID:25449126
NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
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Ung
uracil-DNA glycosylase
decreases expression
ISO
Chlorpromazine analog results in decreased expression of UNG mRNA
CTD
PMID:15924885
NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
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Unkl
unk like zinc finger
decreases expression
EXP
Chlorpromazine results in decreased expression of UNKL mRNA
CTD
PMID:25596134
NCBI chr10:14,206,125...14,252,226
Ensembl chr10:14,206,189...14,252,225
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Vegfa
vascular endothelial growth factor A
increases expression
ISO
Chlorpromazine analog results in increased expression of VEGFA mRNA
CTD
PMID:15924885
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Vegfb
vascular endothelial growth factor B
increases expression
EXP
Chlorpromazine results in increased expression of VEGFB mRNA
CTD
PMID:25596134
NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944
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Wars1
tryptophanyl-tRNA synthetase 1
increases expression
EXP
Chlorpromazine results in increased expression of WARS1 mRNA
CTD
PMID:25596134
NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
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Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Chlorpromazine results in increased expression of WIPI1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
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Xbp1
X-box binding protein 1
affects activity decreases expression
EXP
Chlorpromazine affects the activity of XBP1 protein Chlorpromazine results in decreased expression of XBP1 mRNA
CTD
PMID:25596134
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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Xpc
XPC complex subunit, DNA damage recognition and repair factor
decreases expression
EXP
Chlorpromazine results in decreased expression of XPC mRNA
CTD
PMID:25596134
NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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Xrcc4
X-ray repair cross complementing 4
decreases expression
ISO
Chlorpromazine results in decreased expression of XRCC4 mRNA
CTD
PMID:15924885
NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808
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Yap1
Yes1 associated transcriptional regulator
multiple interactions
ISO
Chlorpromazine results in decreased expression of and results in increased phosphorylation of and affects the localization of YAP1 protein
CTD
PMID:30703373
NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
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