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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiethylperazine
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Accession:CHEBI:9544 term browser browse the term
Definition:A member of the class of phenothiazines that is perazine substituted by a ethylsulfanyl group at position 2.
Synonyms:exact_synonym: 2-(ethylsulfanyl)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
 related_synonym: 2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine;   3-Ethylmercapto-10-(1'-methylpiperazinyl-4'-propyl)phenothiazine;   Ethylthioperazine;   Formula=C22H29N3S2;   InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3;   InChIKey=XCTYLCDETUVOIP-UHFFFAOYSA-N;   SMILES=CCSc1ccc2Sc3ccccc3N(CCCN3CCN(C)CC3)c2c1;   thiethylperazinum;   tietilperazina
 xref: Beilstein:52127;   CAS:1420-55-9;   DrugBank:DB00372;   Drug_Central:2630;   HMDB:HMDB0014516;   KEGG:C07132;   KEGG:D02354;   LINCS:LSM-3556
 xref_mesh: MESH:D013847
 xref: PMID:15469457;   PMID:23243946;   Reaxys:52127;   Wikipedia:Thiethylperazine



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thiethylperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        pharmacological role 19070
          antagonist 16360
            histamine antagonist 4856
              thiethylperazine 2
                thiethylperazine maleate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19744
                        hydrogen molecular entity 19736
                          hydrides 19102
                            inorganic hydride 17893
                              pnictogen hydride 17876
                                nitrogen hydride 17766
                                  azane 17518
                                    ammonia 17517
                                      organic amino compound 17517
                                        tertiary amino compound 8854
                                          N-alkylpiperazine 3346
                                            N-methylpiperazine 1186
                                              perazine 4
                                                thiethylperazine 2
                                                  thiethylperazine maleate 0
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