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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiethylperazine
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Accession:CHEBI:9544 term browser browse the term
Definition:A member of the class of phenothiazines that is perazine substituted by a ethylsulfanyl group at position 2.
Synonyms:exact_synonym: 2-(ethylsulfanyl)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
 related_synonym: 2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine;   3-Ethylmercapto-10-(1'-methylpiperazinyl-4'-propyl)phenothiazine;   Ethylthioperazine;   Formula=C22H29N3S2;   InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3;   InChIKey=XCTYLCDETUVOIP-UHFFFAOYSA-N;   SMILES=CCSc1ccc2Sc3ccccc3N(CCCN3CCN(C)CC3)c2c1;   thiethylperazinum;   tietilperazina
 xref: Beilstein:52127;   CAS:1420-55-9;   DrugBank:DB00372;   Drug_Central:2630;   HMDB:HMDB0014516;   KEGG:C07132;   KEGG:D02354;   LINCS:LSM-3556
 xref_mesh: MESH:D013847
 xref: PMID:15469457;   PMID:23243946;   Reaxys:52127;   Wikipedia:Thiethylperazine


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thiethylperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        pharmacological role 18870
          antagonist 16306
            histamine antagonist 4610
              thiethylperazine 2
                thiethylperazine maleate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    main group molecular entity 19763
                      s-block molecular entity 19511
                        hydrogen molecular entity 19503
                          hydrides 18775
                            inorganic hydride 17505
                              pnictogen hydride 17478
                                nitrogen hydride 17323
                                  azane 17040
                                    ammonia 17039
                                      organic amino compound 17038
                                        tertiary amino compound 8652
                                          N-alkylpiperazine 3082
                                            N-methylpiperazine 853
                                              perazine 4
                                                thiethylperazine 2
                                                  thiethylperazine maleate 0
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