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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fluphenazine
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Accession:CHEBI:5123 term browser browse the term
Definition:A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position.
Synonyms:exact_synonym: 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol
 related_synonym: 1-(2-hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine;   10-(3'-(4''-(beta-hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine;   10-(3-(2-hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine;   2-(4-(3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol;   2-(trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine;   4-(3-(-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol;   4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol;   4-(3-(2-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol;   Fluorfenazine;   Fluorophenazine;   Fluorphenazine;   Formula=C22H26F3N3OS;   InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2;   InChIKey=PLDUPXSUYLZYBN-UHFFFAOYSA-N;   SMILES=OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1;   Triflumethazine;   flufenazina;   fluphenazinum
 xref: Beilstein:1189506;   Beilstein:61643;   CAS:69-23-8;   DrugBank:DB00623;   Drug_Central:1212;   Gmelin:1231182;   HMDB:HMDB0014761;   KEGG:C07010;   KEGG:D07977;   LINCS:LSM-3226
 xref_mesh: MESH:D005476
 xref: PMID:13950763;   PMID:16117689;   PMID:1650428;   PMID:16839522;   PMID:25595294;   PMID:5128930;   Patent:GB829246;   Patent:GB833474;   Patent:US3058979;   Patent:US3194733;   Reaxys:61643;   Wikipedia:Fluphenazine

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fluphenazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase multiple interactions
decreases activity		 EXP [Fluphenazine co-treated with diphenyldiselenide] results in decreased activity of ALAD protein
Fluphenazine results in decreased activity of ALAD protein		 CTD PMID:19486337 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346 		JBrowse link
G Ar androgen receptor multiple interactions ISO Fluphenazine binds to and results in decreased activity of AR protein CTD PMID:17606915 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Cat catalase multiple interactions
increases activity		 EXP diphenyldiselenide inhibits the reaction [Fluphenazine results in increased activity of CAT protein] CTD PMID:19486337 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity ISO Fluphenazine results in decreased activity of CYP2C9 protein CTD PMID:15135088 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO Fluphenazine results in decreased activity of CYP2C19 protein CTD PMID:15135088 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Fluphenazine results in decreased activity of CYP2E1 protein CTD PMID:15135088 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO Fluphenazine results in decreased activity of CYP3A4 protein CTD PMID:15135088 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Drd2 dopamine receptor D2 affects binding ISO Fluphenazine binds to DRD2 protein CTD PMID:17606915 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects binding ISO Fluphenazine binds to HTR2A protein CTD PMID:17606915 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding ISO Fluphenazine binds to HTR2C protein CTD PMID:17606915 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP Fluphenazine inhibits the reaction [NGF protein results in increased uptake of Calcium] CTD PMID:1374475 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Prl prolactin increases secretion ISO Fluphenazine results in increased secretion of PRL protein CTD PMID:9989566 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Fluphenazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression ISO Fluphenazine results in decreased expression of TAC1 mRNA CTD PMID:15845098 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819 		JBrowse link
G Tfeb transcription factor EB affects localization ISO Fluphenazine affects the localization of TFEB protein CTD PMID:28366621 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        antimicrobial agent 17383
          antiviral agent 10263
            anticoronaviral agent 8954
              fluphenazine 15
                fluphenazine decanoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic molecule 19556
                              organic cyclic compound 19365
                                organic heterocyclic compound 18486
                                  organic heteropolycyclic compound 17874
                                    organic heterotricyclic compound 14593
                                      mancude organic heterotricyclic parent 353
                                        phenothiazine 28
                                          10H-phenothiazine 28
                                            fluphenazine 15
                                              fluphenazine decanoate 0
paths to the root