CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: fluphenazine
Accession: CHEBI:5123
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Definition: A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position.
Synonyms: exact_synonym: 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol
related_synonym: 1-(2-hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine; 10-(3'-(4''-(beta-hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine; 10-(3-(2-hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine; 2-(4-(3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol; 2-(trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine; 4-(3-(-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol; 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol; 4-(3-(2-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol; Fluorfenazine; Fluorophenazine; Fluorphenazine; Formula=C22H26F3N3OS; InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2; InChIKey=PLDUPXSUYLZYBN-UHFFFAOYSA-N; SMILES=OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1; Triflumethazine; flufenazina; fluphenazinum
xref: Beilstein:1189506; Beilstein:61643; CAS:69-23-8; DrugBank:DB00623; Drug_Central:1212; Gmelin:1231182; HMDB:HMDB0014761; KEGG:C07010; KEGG:D07977; LINCS:LSM-3226
xref_mesh: MESH:D005476
xref: PMID:13950763; PMID:16117689; PMID:1650428; PMID:16839522; PMID:25595294; PMID:5128930; Patent:GB829246; Patent:GB833474; Patent:US3058979; Patent:US3194733; Reaxys:61643; Wikipedia:Fluphenazine
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Alad
aminolevulinate dehydratase
multiple interactions decreases activity
EXP
[Fluphenazine co-treated with diphenyldiselenide] results in decreased activity of ALAD protein Fluphenazine results in decreased activity of ALAD protein
CTD
PMID:19486337
NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
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Ar
androgen receptor
multiple interactions
ISO
Fluphenazine binds to and results in decreased activity of AR protein
CTD
PMID:17606915
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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Cat
catalase
multiple interactions increases activity
EXP
diphenyldiselenide inhibits the reaction [Fluphenazine results in increased activity of CAT protein]
CTD
PMID:19486337
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
decreases activity
ISO
Fluphenazine results in decreased activity of CYP2C9 protein
CTD
PMID:15135088
NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
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Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
decreases activity
ISO
Fluphenazine results in decreased activity of CYP2C19 protein
CTD
PMID:15135088
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases activity
ISO
Fluphenazine results in decreased activity of CYP2E1 protein
CTD
PMID:15135088
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
decreases activity
ISO
Fluphenazine results in decreased activity of CYP3A4 protein
CTD
PMID:15135088
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Drd2
dopamine receptor D2
affects binding
ISO
Fluphenazine binds to DRD2 protein
CTD
PMID:17606915
NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
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Htr2a
5-hydroxytryptamine receptor 2A
affects binding
ISO
Fluphenazine binds to HTR2A protein
CTD
PMID:17606915
NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
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Htr2c
5-hydroxytryptamine receptor 2C
affects binding
ISO
Fluphenazine binds to HTR2C protein
CTD
PMID:17606915
NCBI chr X:118,084,520...118,318,040
Ensembl chr X:118,084,890...118,318,039
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Ngf
nerve growth factor
multiple interactions
EXP
Fluphenazine inhibits the reaction [NGF protein results in increased uptake of Calcium]
CTD
PMID:1374475
NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
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Prl
prolactin
increases secretion
ISO
Fluphenazine results in increased secretion of PRL protein
CTD
PMID:9989566
NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Fluphenazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
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Tac1
tachykinin, precursor 1
decreases expression
ISO
Fluphenazine results in decreased expression of TAC1 mRNA
CTD
PMID:15845098
NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
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Tfeb
transcription factor EB
affects localization
ISO
Fluphenazine affects the localization of TFEB protein
CTD
PMID:28366621
NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596
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